Hub : Genes

LPL

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0910 0.0340 9.0e-04 0.002 0.021 0.000 0.021 0.002 1.6e-01 1.3e-03 3.5e-01 1.0e-03 1.8e-01
2 GTEx Vagina 0.5820 0.1320 3.1e-03 -0.013 NA -0.005 NA -0.013 8.8e-01 NA 4.4e-01 NA 9.2e-01
3 NTR Blood 0.0816 0.0161 7.4e-15 0.046 0.058 0.059 0.065 0.059 1.1e-14 5.2e-18 1.8e-18 5.5e-20 2.9e-18
4 YFS Blood 0.0613 0.0155 5.4e-09 0.066 0.024 0.046 0.060 0.063 1.1e-20 1.5e-08 6.9e-15 8.2e-19 6.5e-20
5 TCGA Kidney Renal Clear Cell Carcinoma 0.0277 0.0157 4.4e-03 0.004 0.003 -0.002 NA -0.001 1.1e-01 1.3e-01 5.4e-01 NA 4.7e-01
6 TCGA Brain Lower Grade Glioma 0.0912 0.0309 4.6e-11 0.118 0.101 0.097 NA 0.107 2.5e-13 1.4e-11 4.1e-11 NA 3.5e-12

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.4 0.6 2.3 -0.6 0.0 0.0 -0.1 0.9 -1.5
Bipolar Disorder or Schizophrenia 0.4 0.9 2.3 0.2 0.0 -1.5 -1.5 -0.3 -0.8
Depressed Affect (Nagel 2018) 1.4 2.9 6.4 0.5 0.0 -2.1 -2.5 -2.4 0.3
Depression (Nagel 2018) 3.1 4.6 9.2 1.4 0.0 -3.0 -2.8 -2.6 1.4
Intelligence (Savage-Jansen 2018) 0.2 0.7 2.0 -1.4 0.0 0.3 -0.1 0.4 -1.3
Neuroticism (Nagel 2018) 0.3 0.6 1.6 0.4 0.0 -1.1 -0.7 -0.3 -1.3
Schizophrenia (2018) 0.7 1.5 3.9 0.7 0.0 -2.0 -1.9 -0.9 0.2
Schizophrenia vs Biploar Disorder 0.0 0.1 0.2 -0.3 0.0 -0.2 -0.1 -0.1 0.4
Worry (Nagel 2018) 0.4 0.7 3.0 1.7 0.0 -0.6 -0.1 0.7 -0.8
Alzheimer’s Disease (in mother) 0.9 1.1 2.8 1.3 0.0 -1.7 -1.4 -0.3 -0.3
Alzheimer’s Disease (in father) 0.5 0.6 1.4 0.2 0.0 -1.2 -0.8 -0.6 0.9
Alzheimer’s Disease (including proxy) 1.1 1.6 3.7 1.8 0.0 -1.9 -1.5 0.2 0.0
Crohns Disease (2017) 0.9 2.0 3.0 1.7 0.0 -1.6 -0.8 -1.7 1.7
Irritable Bowel Disease (IBD) 1.0 2.4 3.9 1.8 0.0 -2.0 -1.5 -1.6 1.6
Ulcerative Colitis (UC) 0.5 1.0 3.2 0.8 0.0 -1.8 -1.2 -0.7 0.4
Major Depression (MDD) 0.5 0.6 1.2 -0.7 0.0 -1.1 -0.6 -0.7 -0.9
Reaction Time 1.2 2.3 4.3 -1.4 0.0 1.8 1.6 2.1 -1.3
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.8 -0.9 0.0 -0.2 0.2 -0.2 -0.2
Breast Cancer 0.4 0.9 3.2 0.1 0.0 -1.0 -1.8 -1.0 -0.0
Ovarian Cancer 0.5 0.6 1.3 -1.1 0.0 -0.3 -0.2 1.1 -1.1
Prostate Cancer 0.3 0.5 1.0 -1.0 0.0 1.0 0.6 0.3 -0.7
Age at First Birth 0.8 1.1 2.9 -1.7 0.0 1.2 1.2 -0.3 -1.0
Bipolar Disorder (2011) 0.1 0.1 0.5 -0.2 0.0 0.7 -0.1 0.2 -0.1
Body Mass Index (BMI) (2010) 1.9 2.5 5.4 1.7 0.0 -1.2 -1.5 -2.3 1.8
Coronary Artery Disease (CAD) 9.0 10.7 28.7 1.8 0.0 -2.4 -3.5 -5.4 3.9
Crohns Disease (2012) 1.3 2.1 3.7 1.6 0.0 -1.5 -1.0 -1.9 1.6
Mean Putamen Volume 2.1 2.4 6.2 2.5 0.0 -1.1 -1.9 -1.0 1.6
Fasting Glucose 1.3 1.6 4.2 1.0 0.0 -2.0 -1.1 -1.4 1.1
HbA1C 1.2 1.4 3.2 -1.8 0.0 1.1 0.6 0.9 -1.6
HDL Cholesterol 169.0 281.9 449.4 -14.8 0.0 16.9 18.8 21.2 -19.6
LDL Cholesterol 0.4 0.6 1.9 -0.2 0.0 0.7 0.2 -1.0 1.4
Lupus 0.3 0.5 1.6 1.1 0.0 0.4 -0.3 0.2 1.3
Neuroticism (2016) 0.4 0.5 1.3 -0.7 0.0 -1.0 -0.3 -0.4 -1.1
Primary Biliary Cirrhosis 0.1 0.2 0.7 -0.4 0.0 -0.3 -0.8 -0.0 -0.2
Rheumatoid Arthritis 0.3 0.5 1.2 -1.1 0.0 -0.6 -0.9 0.2 -0.6
Schizophrenia (2014) 0.9 2.0 5.4 0.6 0.0 -2.3 -2.3 -1.0 0.5
Triglycerides 194.9 319.1 475.2 15.5 0.0 -17.8 -20.5 -21.8 21.5
Type 2 Diabetes (T2D) (2012) 4.1 4.7 9.1 1.6 0.0 -2.0 -2.2 -3.0 2.8
Ulcerative Colitis 0.5 0.7 2.1 0.9 0.0 -1.1 -1.5 -0.5 0.3
Blood Eosinophil Count 2.6 20.1 30.2 -5.2 0.0 3.6 5.5 4.9 -5.2
Blood Platelet Count 0.8 9.4 14.7 -2.9 0.0 3.1 3.5 3.8 -3.4
Blood Red Count 0.5 4.4 9.4 2.6 0.0 -1.7 -1.5 -2.2 3.1
Blood White Count 0.7 5.0 10.4 1.8 0.0 -2.5 -2.4 -3.2 2.1
Heel T-Score 0.2 1.3 3.0 0.3 0.0 -1.7 -1.7 -1.3 0.1
BMI 0.8 4.6 13.7 0.7 0.0 -0.8 -1.3 -3.7 3.4
Height 0.8 14.6 23.9 -3.3 0.0 4.0 4.9 4.2 -4.3
Waist Hip Ratio (WHR) 3.0 13.3 24.4 3.0 0.0 -3.4 -3.8 -4.4 4.9
Systolic Blood Pressure 0.9 4.3 9.4 2.4 0.0 -2.8 -3.1 -1.5 1.0
Smoking Status 0.9 2.2 5.9 0.5 0.0 -1.8 -1.3 -2.4 1.4
Allergy or Eczema 0.1 0.2 0.5 -0.7 0.0 0.2 0.7 -0.4 0.0
Cardiovascular Disease 6.1 20.2 31.2 3.6 0.0 -5.4 -5.6 -5.4 4.3
Hypothyroidism (self reported) 0.1 0.3 0.7 -0.8 0.0 -0.5 0.2 -0.8 -0.6
Respiratory disease 0.6 1.3 5.1 0.9 0.0 -2.3 -0.2 -1.3 0.5
Type 2 Diabetes (T2D) (2018) 4.8 8.9 17.5 0.7 0.0 -4.0 -3.9 -4.2 2.1
Lung FEV1/FVC ratio 0.7 3.4 11.0 -2.0 0.0 3.3 1.3 1.6 -1.0
Lung FVC 0.5 2.3 6.5 2.6 0.0 -2.0 -1.6 -0.1 0.9
Neuroticism 0.2 0.5 1.8 -0.1 0.0 -0.7 -0.6 0.2 -1.3
Chronotype (morning person) 0.7 1.7 3.8 -0.6 0.0 1.1 0.9 1.9 -2.0
Hair Pigment 0.1 1.7 4.7 1.9 0.0 -1.3 -2.2 -0.2 -0.3
Tanning 0.0 0.3 0.9 -0.6 0.0 -0.0 0.4 -1.0 0.4
Hand grip strength (left) 0.4 1.1 2.4 0.9 0.0 -1.2 0.0 1.3 -1.6
Number of treatments/medications taken 2.6 4.8 12.6 0.5 0.0 -1.6 -2.6 -3.5 2.5
Average weekly spirits intake 0.7 0.8 4.3 2.1 0.0 0.6 0.1 -0.0 0.5
Sensitivity / hurt feelings 0.3 0.5 1.1 -0.9 0.0 0.4 1.0 0.1 -1.0
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.3 -0.1 0.0 -0.6 -0.7 -1.1 0.6
Hearing difficulty/problems: Yes 1.8 2.7 7.7 -1.8 0.0 2.8 1.6 1.4 -1.0
Relative age of first facial hair 0.6 1.2 3.3 -0.5 0.0 0.4 0.6 1.8 -1.7
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.6 0.6 0.0 -0.8 -1.2 0.0 0.3
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.6 -0.2 0.0 0.4 -0.5 0.6 -0.8
Ever had hysterectomy (womb removed) 1.3 1.5 3.5 1.4 0.0 -1.9 -1.2 1.4 -0.7
Systolic blood pressure, automated reading 0.2 0.7 2.6 0.6 0.0 -1.0 -1.6 0.2 -0.6
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 1.7 -0.4 0.0 -0.3 -0.8 -1.3 0.6
Angina 10.6 13.9 25.5 3.0 0.0 -3.8 -3.7 -5.0 4.6
Medication for hormone replacement therapy 0.5 0.6 1.7 1.3 0.0 -0.1 -0.9 -0.5 0.7
Vitamin and mineral supplements 1.0 1.4 3.6 -0.6 0.0 0.9 0.9 1.7 -1.9
Supplements: Zinc 0.4 0.5 1.0 0.6 0.0 -0.8 -1.0 -0.9 0.1
Medication: Co-codamol 0.3 0.3 1.1 0.6 0.0 0.5 -0.4 -0.3 1.0
Medication: Metformin 4.1 5.8 16.2 0.1 0.0 -2.7 -2.5 -4.0 2.2
Diabetes (father) 0.4 0.5 0.8 -0.9 0.0 -0.8 -0.9 -0.7 -0.1
Diabetes (mother) 0.4 0.5 1.1 -1.0 0.0 0.7 1.0 0.2 -0.7
Severe depression (siblings) 0.5 0.5 1.7 -0.5 0.0 -0.4 0.7 0.8 -1.3
Pack years adult smoking proportion 1.3 2.0 3.6 1.9 0.0 -1.9 -1.2 -1.5 1.1
Impedance of leg (right) 1.3 6.5 10.5 -0.9 0.0 3.1 2.9 3.2 -3.1
Leg fat-free mass (left) 0.3 1.3 4.4 -0.7 0.0 -0.8 -0.3 -2.1 1.5
Trunk fat percentage 0.3 1.4 3.3 -0.9 0.0 1.8 1.4 -1.1 1.0
Hand grip strength (right) 0.6 1.7 5.3 0.6 0.0 -0.4 -0.2 2.3 -2.0
Townsend deprivation index at recruitment 2.3 3.2 5.7 1.4 0.0 -1.9 -2.0 -2.4 1.9
Current tobacco smoking 1.0 1.7 3.4 0.6 0.0 -1.8 -1.9 -1.3 1.2
Average weekly fortified wine intake 0.3 0.3 0.9 -0.5 0.0 1.0 0.8 0.2 -0.2
Maternal smoking around birth 1.6 2.3 5.6 0.2 0.0 -2.4 -1.5 -2.1 1.3
Fed-up feelings 0.9 1.6 4.6 0.5 0.0 -1.7 -1.3 -2.1 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 3.9 5.2 8.3 2.2 0.0 -2.8 -2.3 -2.9 2.2
Relative age voice broke 0.3 0.5 2.1 0.1 0.0 0.8 0.3 1.4 -0.2
Taking other prescription medications 1.2 1.8 6.0 0.2 0.0 -0.6 -1.2 -2.5 1.7
Age when periods started (menarche) 0.2 0.4 1.2 0.8 0.0 -0.1 0.4 -1.1 0.4
Bilateral oophorectomy (both ovaries removed) 0.9 1.1 3.3 1.8 0.0 -1.2 -0.8 -0.7 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.4 -0.4 0.0 -1.2 -0.9 -0.8 -0.6
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 2.6 -0.7 0.0 0.5 1.6 1.4 -1.6
Qualifications: CSEs or equivalent 1.6 2.0 3.3 0.6 0.0 -1.7 -1.8 -1.8 1.6
Serious illness, injury or assault to yourself 0.8 1.0 1.9 1.1 0.0 -0.6 -1.3 -0.9 1.4
High blood pressure 0.7 2.0 5.2 0.9 0.0 -2.3 -2.2 -1.0 -0.1
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.9 -0.2 0.0 0.5 1.0 -0.1 0.3
Multivitamins +/- minerals 1.2 1.6 3.5 1.2 0.0 -1.1 -0.9 -1.6 1.9
Stomach or abdominal pain in last month 1.2 1.5 3.4 1.3 0.0 -0.7 -1.0 -1.6 1.8
Supplements: Glucosamine 0.1 0.2 0.5 -0.7 0.0 -0.4 -0.4 0.3 0.3
Diverticular disease/diverticulitis (self-reported) 1.5 1.7 3.0 1.7 0.0 -0.7 -1.6 -1.2 1.7
Medication: Atenolol 2.3 2.9 8.1 0.1 0.0 -1.7 -2.2 -2.8 1.3
Medication: Levothyroxine sodium 0.2 0.3 1.2 -0.2 0.0 -1.1 -0.2 -0.3 -0.4
Sitting height 0.0 0.2 0.5 -0.2 0.0 -0.7 0.4 -0.4 0.3
Chronic bronchitis/emphysema (father) 3.6 4.2 7.6 -1.2 0.0 2.6 2.8 2.2 -2.0
High blood pressure (mother) 0.3 0.4 1.8 -1.4 0.0 0.6 -0.0 0.0 -0.3
Body mass index (BMI) 0.7 2.9 9.0 0.5 0.0 -1.0 -1.5 -3.0 2.2
Impedance of leg (left) 1.5 7.1 13.1 -1.1 0.0 3.2 3.0 3.6 -3.0
Leg predicted mass (left) 0.3 1.4 4.6 -0.8 0.0 -0.9 -0.3 -2.1 1.5
Trunk fat mass 0.3 1.1 1.7 -1.0 0.0 1.3 1.1 -1.3 1.0
Waist circumference 0.7 2.5 6.6 0.3 0.0 -1.0 -1.5 -2.6 2.2
Number of incorrect matches in round 0.9 1.4 5.9 1.3 0.0 -0.6 -2.4 -0.5 0.6
Past tobacco smoking 0.4 0.7 2.2 0.4 0.0 1.2 0.4 1.5 -0.4
Alcohol usually taken with meals 0.2 0.3 1.2 -0.6 0.0 1.1 -0.2 0.7 -0.1
Nervous feelings 0.3 0.5 1.7 0.7 0.0 -0.0 0.2 1.3 -0.8
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 1.7 0.5 0.0 -1.3 -1.2 -1.0 0.9
Hearing difficulty/problems with background noise 1.3 2.0 5.1 -1.6 0.0 0.9 1.4 1.3 -2.2
Hair/balding pattern: Pattern 2 5.5 7.0 12.9 2.0 0.0 -3.6 -3.3 -2.8 2.5
Had menopause 3.5 4.3 15.3 -1.0 0.0 1.5 0.8 3.9 -2.6
Had other major operations 0.5 0.6 1.7 0.3 0.0 -0.3 -1.3 -0.8 0.9
Forced vital capacity (FVC) 0.1 0.6 2.0 0.3 0.0 1.0 1.4 0.1 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.8 -0.6 0.0 -1.3 -1.2 -0.8 -0.4
Ever unenthusiastic/disinterested for a whole week 0.4 0.4 1.7 -0.4 0.0 0.0 0.3 0.7 -1.3
Qualifications: None of the above 0.6 1.3 2.4 1.5 0.0 -0.9 -1.6 -1.1 1.1
Financial difficulties in last 2 years 2.9 3.9 6.6 1.9 0.0 -2.2 -2.6 -2.1 1.9
Mouth/teeth dental problems 0.8 1.3 4.3 -2.1 0.0 1.0 0.9 -0.2 -1.2
Heart attack 5.7 7.3 21.8 2.4 0.0 -1.2 -1.5 -4.7 3.5
Allergy 0.1 0.3 1.0 0.6 0.0 -0.2 -1.0 0.5 -0.2
Pain all over the body in last month 0.4 0.4 1.0 -0.9 0.0 -0.9 0.3 -1.0 0.3
Diabetes (self-reported) 3.0 4.7 8.7 0.4 0.0 -2.8 -2.8 -3.0 1.8
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.4 0.1 0.0 0.2 0.6 0.1 0.3
Medication: Ramipril 1.3 1.7 3.0 1.1 0.0 -1.7 -1.1 -1.7 1.4
Medication: Simvastatin 14.3 21.0 29.6 4.8 0.0 -4.8 -5.1 -5.4 5.0
Fluid intelligence score 0.2 0.4 1.0 -0.2 0.0 -1.0 -0.6 -0.9 -0.4
Illnesses of siblings 3.0 4.1 6.9 -2.5 0.0 1.4 2.3 2.6 -2.1
Neuroticism score 0.1 0.2 1.1 -0.1 0.0 -0.3 0.1 0.2 -1.1
Weight 0.2 0.7 2.8 -0.8 0.0 -0.0 0.1 -1.7 1.0
Impedance of arm (right) 1.1 5.2 9.9 -1.6 0.0 3.2 3.1 2.4 -1.8
Arm fat percentage (right) 0.5 2.0 7.0 0.2 0.0 0.1 -0.3 -2.7 2.2
Trunk fat-free mass 0.1 0.4 1.1 -0.8 0.0 -1.1 -0.3 -0.7 0.1
Hip circumference 0.1 0.5 1.5 -0.7 0.0 1.2 0.9 -0.1 0.3
Time employed in main current job 0.9 1.0 3.5 -0.6 0.0 1.3 1.9 0.6 -0.2
Alcohol intake versus 10 years previously 1.7 2.6 7.2 1.8 0.0 -1.6 -2.7 -1.2 1.1
Father’s age at death 5.1 6.8 19.6 -1.3 0.0 2.4 2.3 4.4 -2.9
Worrier / anxious feelings 0.8 1.4 4.0 -0.4 0.0 0.7 1.4 1.4 -2.0
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.8 5.5 -0.2 0.0 -1.5 -1.3 -2.3 1.2
Falls in the last year 0.6 0.9 2.2 0.2 0.0 -1.5 -0.8 0.8 -1.2
Hair/balding pattern: Pattern 3 0.7 1.0 3.2 0.6 0.0 1.8 0.8 1.1 0.7
Number of live births 0.2 0.2 1.2 -0.4 0.0 0.1 -1.1 0.1 0.3
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 2.5 -0.1 0.0 1.4 1.6 0.3 0.6
Pulse rate 0.8 1.4 3.0 1.7 0.0 -1.2 -1.0 -1.4 1.1
Happiness 0.4 0.5 1.6 1.3 0.0 -0.1 -0.3 -0.4 1.0
Noisy workplace 0.1 0.1 0.2 0.4 0.0 0.4 0.5 -0.2 0.3
Qualifications: A levels/AS levels or equivalent 0.9 2.0 4.8 -2.2 0.0 0.8 1.6 0.5 -1.8
Serious illness, injury or assault of a close relative in last 2 years 1.8 2.1 5.7 -2.4 0.0 -0.0 1.2 1.5 -1.9
Mouth/teeth dental problems: Dentures 0.3 0.6 2.3 0.8 0.0 0.5 0.2 1.5 -0.5
Asthma 0.1 0.3 0.7 -0.2 0.0 -0.6 0.6 -0.8 0.6
Medication: Ibuprofen (e.g. Nurofen) 3.0 3.7 6.4 2.5 0.0 -1.7 -1.8 -2.1 2.3
Medication: Cholesterol lowering 20.4 31.7 54.2 4.7 0.0 -6.0 -6.5 -7.4 5.9
Depression (self-reported) 0.4 0.5 2.1 -0.5 0.0 1.5 0.3 -0.8 -0.0
Medication: Lansoprazole 0.2 0.2 0.9 0.5 0.0 -0.9 -0.3 -0.2 0.1
Prospective memory result 1.2 1.4 4.8 1.9 0.0 0.0 -0.1 -0.4 2.2
Lung cancer (father) 0.5 0.5 1.6 -0.1 0.0 0.1 1.3 0.6 -1.1
Illnesses of mother 0.9 1.1 2.9 0.3 0.0 1.3 1.2 1.7 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.9 4.9 -0.2 0.0 2.2 2.2 1.3 0.2
Pulse wave Arterial Stiffness index 0.5 0.6 1.5 -0.1 0.0 -0.8 0.8 -0.7 1.2
Impedance of arm (left) 1.1 4.9 9.7 -1.6 0.0 3.1 3.1 2.3 -1.5
Arm fat mass (right) 0.3 1.4 5.2 -0.1 0.0 0.0 -0.3 -2.3 1.7
Trunk predicted mass 0.1 0.4 1.0 -0.8 0.0 -1.0 -0.2 -0.7 0.1
Standing height 0.7 6.8 13.2 -3.0 0.0 2.4 3.6 2.7 -2.4
Length of working week for main job 0.3 0.3 0.9 -0.1 0.0 0.9 0.3 0.8 0.5
Exposure to tobacco smoke at home 0.6 0.7 1.6 0.1 0.0 -1.2 -1.2 -0.7 -0.9
Breastfed as a baby 0.9 1.1 2.4 -1.5 0.0 0.8 0.9 1.4 -1.0
Tense / ‘highly strung’ 0.2 0.4 1.2 0.7 0.0 -0.9 -1.1 -0.2 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 5.3 0.4 0.0 -1.8 -2.3 -1.3 0.1
Hair/balding pattern: Pattern 4 0.4 1.0 5.2 -0.6 0.0 0.3 0.4 0.5 -2.3
Birth weight of first child 0.4 0.6 1.2 0.9 0.0 -0.7 -1.1 -0.6 1.1
Peak expiratory flow (PEF) 0.4 0.8 2.4 -0.5 0.0 1.4 1.6 0.0 0.6
Pulse wave reflection index 0.5 0.6 2.0 -0.6 0.0 0.9 1.4 0.1 0.4
Ever highly irritable/argumentative for 2 days 0.6 0.8 2.3 0.8 0.0 -1.5 -0.7 -0.4 1.0
Loud music exposure frequency 0.4 0.5 1.1 -1.1 0.0 0.6 1.1 -0.0 -0.4
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 4.0 -1.9 0.0 0.8 1.2 0.7 -2.0
Mouth/teeth dental problems: Bleeding gums 4.5 5.8 11.3 2.7 0.0 -3.1 -1.4 -2.2 3.4
Blood clot in the leg (DVT) 0.3 0.4 1.0 0.8 0.0 -0.6 -1.0 0.2 -0.6
Medication: Paracetamol 1.1 1.9 4.6 1.2 0.0 -1.7 -2.1 -1.0 1.2
Headache pain in last month 0.1 0.1 0.4 -0.5 0.0 -0.1 -0.6 -0.4 0.2
Medication for cholesterol, blood pressure or diabetes 5.3 8.7 17.7 -2.1 0.0 3.0 3.3 4.2 -3.2
Glaucoma (self-reported) 1.4 1.7 5.0 -1.1 0.0 -0.2 0.5 1.9 -2.2
Gout (self-reported) 1.5 2.1 4.4 1.7 0.0 -1.7 -1.1 -2.1 1.0
Hypothyroidism/myxoedema (self-reported) 0.2 0.5 1.0 -0.9 0.0 -0.5 -0.2 -0.8 -1.0
Medication: Amlodipine 0.4 0.6 1.2 -0.4 0.0 -1.1 -0.5 -1.1 0.6
Medication: Ventolin 100micrograms inhaler 0.3 0.3 1.3 -0.1 0.0 -0.5 0.5 -0.5 1.1
Birth weight 0.3 0.7 1.9 0.2 0.0 0.7 1.1 1.4 -0.5
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.2 0.1 0.0 -1.1 0.0 -0.5 1.1
High blood pressure (siblings) 2.3 3.3 7.5 1.7 0.0 -1.3 -2.7 -2.3 1.5
Forced vital capacity (FVC), Best measure 0.5 1.7 5.2 0.1 0.0 1.8 2.3 1.2 -0.1
Body fat percentage 0.2 0.9 1.9 -0.4 0.0 1.3 0.8 -1.4 1.1
Leg fat percentage (right) 0.1 0.4 1.4 -0.1 0.0 0.9 0.1 -1.2 0.5
Arm fat-free mass (right) 0.0 0.2 0.6 -0.7 0.0 -0.5 -0.2 -0.8 0.2
Exposure to tobacco smoke outside home 0.8 1.1 3.2 -1.4 0.0 0.8 0.6 0.4 -1.8
Comparative body size at age 10 0.3 0.8 3.5 0.1 0.0 0.3 1.1 0.2 -1.9
Number of full brothers 2.0 2.5 4.7 1.0 0.0 -2.1 -2.2 -1.8 1.3
Worry too long after embarrassment 0.7 1.2 3.5 -1.3 0.0 0.0 1.0 1.0 -1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.6 1.3 -0.2 0.0 -0.9 -1.1 -0.5 -1.0
Wheeze or whistling in the chest in last year 1.8 3.1 9.9 0.8 0.0 -1.8 -0.3 -3.2 2.2
Number of children fathered 0.1 0.2 0.6 -0.8 0.0 -0.5 -0.2 0.1 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 2.0 -1.0 0.0 -1.2 -0.9 -1.4 -0.4
Age at first live birth 2.0 3.5 8.5 -2.3 0.0 1.8 2.9 1.3 -1.6
Pulse wave peak to peak time 0.5 0.6 1.8 0.2 0.0 0.7 -0.7 0.8 -1.3
Health satisfaction 3.6 4.6 8.2 1.5 0.0 -2.9 -2.7 -2.0 2.5
Shortness of breath walking on level ground 1.0 1.2 3.4 1.2 0.0 -1.9 -0.9 -0.8 1.0
Qualifications: College or University degree 1.2 3.8 7.4 -2.7 0.0 2.3 2.2 1.7 -1.5
Eye problems/disorders: None of the above 0.3 0.3 1.2 -0.4 0.0 0.2 1.1 0.0 0.6
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.6 1.2 0.0 -0.4 -1.0 -0.5 0.2
Emphysema/chronic bronchitis 1.6 1.8 4.8 0.7 0.0 -1.6 -0.9 -2.2 1.5
Medication for pain relief, constipation, heartburn 2.1 3.6 7.6 -0.9 0.0 1.6 2.4 2.8 -2.3
Neck or shoulder pain in last month 1.0 1.4 4.6 0.4 0.0 -1.4 -0.4 -1.4 2.1
Medication: Blood pressure 0.6 1.1 2.2 0.6 0.0 -1.3 -1.5 -1.3 0.8
Angina (self-reported) 10.5 13.8 26.3 3.0 0.0 -3.5 -3.7 -5.1 4.7
Migraine (self-reported) 0.2 0.2 0.7 0.2 0.0 0.8 0.7 0.5 -0.1
Medication: Ibuprofen 4.3 5.2 9.1 3.0 0.0 -2.3 -2.4 -2.3 2.3
Medication: Allopurinol 2.1 2.8 8.5 2.9 0.0 -1.2 -0.8 -1.9 1.5
Medication: Omeprazole 0.9 1.0 2.2 0.3 0.0 -0.3 -1.5 -1.3 1.5
Medication: Seretide 50 evohaler 0.6 0.7 1.3 0.9 0.0 0.1 1.1 -0.8 1.1
Mean time to correctly identify matches 1.2 2.3 4.4 -1.6 0.0 1.9 1.0 2.1 -1.5
Heart disease (mother) 1.4 1.7 4.5 -0.2 0.0 -1.0 -1.6 -2.1 1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 1.3 -0.5 0.0 0.9 1.1 0.2 0.5
Whole body fat mass 0.2 0.8 2.2 -0.5 0.0 0.8 0.4 -1.5 1.2
Leg fat mass (right) 0.2 0.7 3.1 -0.2 0.0 0.4 -0.2 -1.8 1.1
Arm predicted mass (right) 0.1 0.3 0.8 -0.5 0.0 -0.6 -0.3 -0.9 0.4
Pulse rate, automated reading 0.5 1.6 2.7 1.5 0.0 -1.6 -1.3 -1.6 0.7
Alcohol intake frequency. 0.6 1.4 2.9 1.2 0.0 -0.6 -1.2 -1.5 1.7
Comparative height size at age 10 0.2 1.3 3.5 -1.9 0.0 0.8 1.8 0.5 -0.6
Number of full sisters 1.1 1.3 3.5 -1.9 0.0 -0.5 -0.6 0.9 -1.8
Suffer from ‘nerves’ 0.1 0.2 1.0 1.0 0.0 -0.3 -0.2 -0.1 0.4
Overall health rating 1.9 4.0 6.4 1.8 0.0 -2.0 -2.1 -2.5 2.5
Chest pain or discomfort 3.0 4.4 12.1 0.4 0.0 -1.5 -0.9 -3.5 3.3
Had major operations 0.7 0.8 2.6 0.3 0.0 -0.3 -0.6 -1.2 1.6
Age at last live birth 0.5 0.7 3.0 -1.7 0.0 0.1 0.6 -0.2 -0.8
Family relationship satisfaction 0.1 0.1 0.5 0.1 0.0 -0.1 0.3 0.7 -0.1
Leg pain on walking 1.2 1.5 5.1 0.3 0.0 -0.4 -0.3 -1.9 2.3
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.4 4.2 0.3 0.0 -1.0 -0.8 -2.0 1.5
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.2 0.6 0.0 -1.1 -0.7 -1.1 1.0
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 4.0 -0.1 0.0 2.0 1.5 0.9 -0.5
Medication: Aspirin 5.7 7.6 20.0 1.1 0.0 -2.6 -2.9 -4.5 2.9
Supplements: Vitamin C 0.1 0.1 0.4 -0.6 0.0 0.4 0.3 -0.4 -0.1
Knee pain experienced in last month 0.2 0.3 0.9 -0.4 0.0 0.5 0.8 -0.2 0.9
Hypertension (Self-reported) 1.2 3.2 7.5 1.2 0.0 -2.7 -2.7 -1.7 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.8 0.9 0.0 -0.6 -0.1 -0.3 0.3
Illnesses of father: Heart disease 10.4 14.4 24.5 2.7 0.0 -3.8 -4.4 -4.9 4.6
Illnesses of siblings: Diabetes 0.6 0.7 2.6 0.8 0.0 -0.4 -0.6 -1.6 0.8
Smoking status: Previous 0.2 0.3 1.2 -0.4 0.0 0.2 1.1 -0.6 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 3.6 -1.7 0.0 1.4 1.9 0.8 -0.3
Whole body fat-free mass 0.1 0.7 1.9 -0.7 0.0 -1.1 -0.4 -1.4 0.8
Leg fat-free mass (right) 0.3 1.5 4.1 -0.9 0.0 -1.1 -0.3 -2.0 1.6
Arm fat percentage (left) 0.5 2.0 7.2 0.1 0.0 0.3 -0.1 -2.7 2.2
Average weekly red wine intake 0.4 0.5 0.9 -0.7 0.0 0.7 0.7 0.9 -0.9
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.3 1.1 0.0 -1.1 -0.3 0.4 0.1
Mood swings 0.4 0.8 2.4 0.3 0.0 -1.2 -1.5 -0.9 0.3
Loneliness, isolation 0.4 0.6 2.3 -0.4 0.0 -0.2 -0.4 -1.5 0.8
Long-standing illness, disability or infirmity 1.9 2.9 4.5 1.7 0.0 -2.1 -1.6 -2.1 1.7
Ever had bowel cancer screening 0.7 0.8 2.2 -0.9 0.0 1.1 0.0 1.5 -0.9
Diabetes diagnosed by doctor 2.2 3.6 7.8 0.0 0.0 -2.6 -2.2 -2.8 1.3
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.0 4.9 -0.2 0.0 -0.7 -0.0 -2.2 0.8
Friendships satisfaction 0.5 0.6 1.8 0.2 0.0 -0.4 -0.7 -1.3 1.0
Qualifications: nursing, teaching 0.5 0.8 1.8 -0.9 0.0 0.7 0.9 1.0 -1.3
Commuting to job workplace: Walk 0.2 0.3 0.9 -0.2 0.0 0.7 1.0 0.1 -0.4
Eye problems/disorders: Cataract 0.6 0.7 2.8 1.0 0.0 0.1 -1.7 -0.1 0.8
Mouth/teeth dental problems: Mouth ulcers 0.6 0.9 2.0 1.1 0.0 -0.7 -0.8 -1.1 1.4
Medication for cholesterol 1.2 1.8 4.3 -0.4 0.0 1.9 2.1 1.5 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.6 -0.1 0.0 -0.2 -0.7 0.7 -0.8
Back pain experienced in last month 0.2 0.3 0.7 -0.2 0.0 0.9 0.2 -0.5 0.8
Mineral and other dietary supplements 0.2 0.3 0.8 0.5 0.0 -0.2 0.4 -0.9 0.8
Breast cancer (self-reported) 0.4 0.4 1.0 -1.0 0.0 0.7 0.9 0.5 -0.3
Asthma (self-reported) 0.1 0.3 0.7 -0.2 0.0 -0.7 0.4 -0.9 0.6
Osteoporosis (self-reported) 0.2 0.3 1.3 -0.2 0.0 0.0 -0.1 -0.6 1.1
Osteoarthritis (self-reported) 0.3 0.4 2.0 -1.4 0.0 0.3 -0.1 -0.3 0.2
Medication: Aspirin 7.5 9.7 24.2 1.5 0.0 -3.1 -3.2 -4.9 3.5
Medication: Gliclazide 0.4 0.5 2.6 0.0 0.0 0.0 -0.4 -1.6 0.5
Illnesses of father: None of the above (group 1) 1.6 2.0 5.2 -0.5 0.0 2.3 1.6 2.0 -0.3
Smoking status: Current 1.4 2.2 4.4 0.5 0.0 -2.0 -2.1 -1.5 1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 5.2 0.7 0.0 2.3 1.5 1.5 0.3
Whole body water mass 0.1 0.6 1.6 -0.7 0.0 -1.0 -0.4 -1.2 0.7
Leg predicted mass (right) 0.3 1.5 4.3 -0.9 0.0 -1.1 -0.3 -2.1 1.7
Arm fat mass (left) 0.5 1.9 7.2 -0.0 0.0 0.0 -0.4 -2.7 1.9
Number of self-reported non-cancer illnesses 0.8 1.3 3.7 0.0 0.0 -1.1 -1.5 -1.9 0.9
Average weekly champagne plus white wine intake 0.6 0.8 2.1 0.2 0.0 1.5 1.4 0.7 0.6
Miserableness 1.2 2.0 5.6 -0.2 0.0 -1.0 -1.8 -2.4 1.5
Guilty feelings 0.9 1.3 2.6 -0.9 0.0 1.0 1.4 1.6 -1.2
Wears glasses or contact lenses 2.9 3.3 7.8 -0.8 0.0 1.7 1.5 2.8 -2.5
Ever taken oral contraceptive pill 0.1 0.1 0.3 0.3 0.0 0.0 0.6 0.1 0.2
Hearing aid user 1.6 1.8 5.3 1.5 0.0 -1.7 -2.3 -0.6 -0.0
Mother’s age at death 1.4 1.7 3.8 -0.3 0.0 1.9 0.4 1.6 -1.9
Financial situation satisfaction 1.5 1.8 5.2 0.9 0.0 -2.0 -2.3 -1.0 0.2
Tinnitus: Yes, now most or all of the time 0.6 0.6 3.4 -1.8 0.0 0.2 -0.6 -0.2 -0.1
Commuting to job workplace: Public transport 0.1 0.1 0.2 0.1 0.0 0.2 0.5 -0.5 0.2
Eye problems/disorders: Glaucoma 2.4 2.9 7.1 -1.1 0.0 0.4 1.7 2.4 -2.7
Medication: Blood pressure 0.2 0.4 1.0 0.1 0.0 -1.0 -0.9 -0.4 -0.1
Pain type(s) experienced in last month: Hip pain 0.5 0.7 2.0 -0.0 0.0 0.4 -0.6 -1.3 1.4
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.4 -0.6 0.0 0.2 -0.0 0.0 -0.7
High cholesterol (Self-reported) 16.5 29.2 47.8 4.4 0.0 -5.7 -6.4 -6.9 5.9
Medication: Bendroflumethiazide 0.8 1.2 2.7 0.1 0.0 -1.4 -1.6 -1.6 0.2
Medication: Paracetamol 2.1 3.2 8.4 1.4 0.0 -2.2 -2.9 -1.5 1.3
Medication: Lisinopril 0.0 0.0 0.2 0.2 0.0 -0.1 -0.0 -0.0 -0.4
Medication: Atorvastatin 9.8 12.1 25.0 2.4 0.0 -3.1 -3.7 -5.0 4.2
Illnesses of father: High blood pressure 0.4 0.5 1.1 -1.1 0.0 -0.6 -0.9 0.5 -0.7
Alcohol drinker status: Never 0.1 0.1 0.2 -0.2 0.0 0.4 -0.2 -0.4 0.5
Ever smoked 0.3 0.5 1.3 -0.8 0.0 -1.0 0.1 -1.1 0.2
Basal metabolic rate 0.1 0.7 2.3 -0.8 0.0 -0.8 -0.3 -1.5 0.9
Leg fat percentage (left) 0.1 0.4 1.0 -0.3 0.0 1.0 0.3 -1.0 0.6
Arm fat-free mass (left) 0.1 0.3 0.8 -0.6 0.0 -0.7 -0.5 -0.9 0.3
Number of operations (self-reported) 0.6 0.8 2.1 -0.0 0.0 -0.2 -1.4 -1.0 1.4
Average weekly beer plus cider intake 0.0 0.1 0.2 -0.3 0.0 -0.1 -0.5 0.2 -0.2
Irritability 1.0 1.6 2.7 -1.2 0.0 1.3 1.5 1.6 -1.4
Risk taking 0.9 1.4 2.8 -1.1 0.0 -1.4 -1.5 -1.7 0.3
Ever had prostate specific antigen (PSA) test 4.6 5.3 12.1 -2.6 0.0 3.5 2.9 1.4 -1.7
Fractured/broken bones in last 5 years 0.6 0.8 1.9 -1.3 0.0 0.2 1.4 0.5 -0.8
Age started oral contraceptive pill 4.1 5.1 9.0 -2.5 0.0 2.4 1.1 3.0 -3.0
Diastolic blood pressure, automated reading 0.1 0.2 0.7 0.9 0.0 -0.3 -0.5 0.1 0.2
Ever depressed for a whole week 0.8 0.9 2.1 -0.5 0.0 0.2 1.2 1.3 -1.4
Unable to work because of sickness or disability 0.8 1.1 2.0 0.8 0.0 -0.9 -1.2 -1.3 1.4
Commuting to job workplace: Cycle 2.4 2.9 6.1 -1.0 0.0 1.9 2.5 2.0 -1.6
Myopia 0.4 0.5 1.4 0.6 0.0 -0.6 -0.6 -0.9 1.2
Vascular/heart problems diagnosed by doctor 1.5 4.2 9.9 -1.5 0.0 3.1 2.7 2.1 -1.0
Cholesterol lowering medication 10.4 15.4 30.6 1.9 0.0 -4.4 -4.9 -5.5 3.8
Medication: Omeprazole (e.g. Zanprol) 0.1 0.2 0.4 -0.6 0.0 0.3 -0.4 -0.1 0.5
Pain experienced in last month 0.1 0.1 0.2 0.4 0.0 -0.1 -0.4 -0.3 -0.2
Supplements: Calcium 0.3 0.4 1.0 -0.9 0.0 0.4 0.0 0.6 -1.0
Basal cell carcinoma (self-reported) 0.2 0.3 0.7 0.6 0.0 -0.3 -0.8 -0.6 0.3
Heart attack/myocardial infarction (self-reported) 6.0 7.7 22.8 2.4 0.0 -1.3 -1.8 -4.8 3.6
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.5 0.9 0.0 -0.8 -1.2 -0.1 -0.3
Heart disease (siblings) 3.0 3.7 7.2 1.9 0.0 -1.8 -2.2 -2.7 1.8
Alcohol drinker status: Previous 0.5 0.6 2.3 -0.3 0.0 0.6 1.5 -0.5 0.8
Pack years of smoking 0.7 1.0 2.7 1.7 0.0 -1.3 -0.7 -0.8 0.7
Impedance of whole body 1.4 7.3 13.0 -1.4 0.0 3.6 3.5 3.3 -2.4
Leg fat mass (left) 0.2 0.7 2.5 -0.3 0.0 0.5 -0.0 -1.6 1.1
Arm predicted mass (left) 0.1 0.3 0.8 -0.5 0.0 -0.9 -0.6 -0.7 0.3