TWAS hub - LPL

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0910	0.0340	9.0e-04	0.002	0.021	0.000	0.021	0.002	1.6e-01	1.3e-03	3.5e-01	1.0e-03	1.8e-01
2	GTEx	Vagina	0.5820	0.1320	3.1e-03	-0.013	NA	-0.005	NA	-0.013	8.8e-01	NA	4.4e-01	NA	9.2e-01
3	NTR	Blood	0.0816	0.0161	7.4e-15	0.046	0.058	0.059	0.065	0.059	1.1e-14	5.2e-18	1.8e-18	5.5e-20	2.9e-18
4	YFS	Blood	0.0613	0.0155	5.4e-09	0.066	0.024	0.046	0.060	0.063	1.1e-20	1.5e-08	6.9e-15	8.2e-19	6.5e-20
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0277	0.0157	4.4e-03	0.004	0.003	-0.002	NA	-0.001	1.1e-01	1.3e-01	5.4e-01	NA	4.7e-01
6	TCGA	Brain Lower Grade Glioma	0.0912	0.0309	4.6e-11	0.118	0.101	0.097	NA	0.107	2.5e-13	1.4e-11	4.1e-11	NA	3.5e-12

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	4	5	6
Triglycerides	194.9	319.1	475.2	15.5	-17.8	-20.5	-21.8	21.5
HDL Cholesterol	169.0	281.9	449.4	-14.8	16.9	18.8	21.2	-19.6
Medication: Cholesterol lowering	20.4	31.7	54.2	4.7	-6.0	-6.5	-7.4	5.9
High cholesterol (Self-reported)	16.5	29.2	47.8	4.4	-5.7	-6.4	-6.9	5.9
Medication: Simvastatin	14.3	21.0	29.6	4.8	-4.8	-5.1	-5.4	5.0
Angina	10.6	13.9	25.5	3.0	-3.8	-3.7	-5.0	4.6
Angina (self-reported)	10.5	13.8	26.3	3.0	-3.5	-3.7	-5.1	4.7
Illnesses of father: Heart disease	10.4	14.4	24.5	2.7	-3.8	-4.4	-4.9	4.6
Cholesterol lowering medication	10.4	15.4	30.6	1.9	-4.4	-4.9	-5.5	3.8
Medication: Atorvastatin	9.8	12.1	25.0	2.4	-3.1	-3.7	-5.0	4.2
Coronary Artery Disease (CAD)	9.0	10.7	28.7	1.8	-2.4	-3.5	-5.4	3.9
Medication: Aspirin	7.5	9.7	24.2	1.5	-3.1	-3.2	-4.9	3.5
Cardiovascular Disease	6.1	20.2	31.2	3.6	-5.4	-5.6	-5.4	4.3
Heart attack/myocardial infarction (self-reported)	6.0	7.7	22.8	2.4	-1.3	-1.8	-4.8	3.6
Heart attack	5.7	7.3	21.8	2.4	-1.2	-1.5	-4.7	3.5
Medication: Aspirin	5.7	7.6	20.0	1.1	-2.6	-2.9	-4.5	2.9
Hair/balding pattern: Pattern 2	5.5	7.0	12.9	2.0	-3.6	-3.3	-2.8	2.5
Medication for cholesterol, blood pressure or diabetes	5.3	8.7	17.7	-2.1	3.0	3.3	4.2	-3.2
Father’s age at death	5.1	6.8	19.6	-1.3	2.4	2.3	4.4	-2.9
Type 2 Diabetes (T2D) (2018)	4.8	8.9	17.5	0.7	-4.0	-3.9	-4.2	2.1
Ever had prostate specific antigen (PSA) test	4.6	5.3	12.1	-2.6	3.5	2.9	1.4	-1.7
Mouth/teeth dental problems: Bleeding gums	4.5	5.8	11.3	2.7	-3.1	-1.4	-2.2	3.4
Medication: Ibuprofen	4.3	5.2	9.1	3.0	-2.3	-2.4	-2.3	2.3
Type 2 Diabetes (T2D) (2012)	4.1	4.7	9.1	1.6	-2.0	-2.2	-3.0	2.8
Medication: Metformin	4.1	5.8	16.2	0.1	-2.7	-2.5	-4.0	2.2
Age started oral contraceptive pill	4.1	5.1	9.0	-2.5	2.4	1.1	3.0	-3.0
Frequency of unenthusiasm / disinterest in last 2 weeks	3.9	5.2	8.3	2.2	-2.8	-2.3	-2.9	2.2
Chronic bronchitis/emphysema (father)	3.6	4.2	7.6	-1.2	2.6	2.8	2.2	-2.0
Health satisfaction	3.6	4.6	8.2	1.5	-2.9	-2.7	-2.0	2.5
Had menopause	3.5	4.3	15.3	-1.0	1.5	0.8	3.9	-2.6
Depression (Nagel 2018)	3.1	4.6	9.2	1.4	-3.0	-2.8	-2.6	1.4
Waist Hip Ratio (WHR)	3.0	13.3	24.4	3.0	-3.4	-3.8	-4.4	4.9
Diabetes (self-reported)	3.0	4.7	8.7	0.4	-2.8	-2.8	-3.0	1.8
Illnesses of siblings	3.0	4.1	6.9	-2.5	1.4	2.3	2.6	-2.1
Medication: Ibuprofen (e.g. Nurofen)	3.0	3.7	6.4	2.5	-1.7	-1.8	-2.1	2.3
Chest pain or discomfort	3.0	4.4	12.1	0.4	-1.5	-0.9	-3.5	3.3
Heart disease (siblings)	3.0	3.7	7.2	1.9	-1.8	-2.2	-2.7	1.8
Financial difficulties in last 2 years	2.9	3.9	6.6	1.9	-2.2	-2.6	-2.1	1.9
Wears glasses or contact lenses	2.9	3.3	7.8	-0.8	1.7	1.5	2.8	-2.5
Blood Eosinophil Count	2.6	20.1	30.2	-5.2	3.6	5.5	4.9	-5.2
Number of treatments/medications taken	2.6	4.8	12.6	0.5	-1.6	-2.6	-3.5	2.5
Eye problems/disorders: Glaucoma	2.4	2.9	7.1	-1.1	0.4	1.7	2.4	-2.7
Commuting to job workplace: Cycle	2.4	2.9	6.1	-1.0	1.9	2.5	2.0	-1.6
Townsend deprivation index at recruitment	2.3	3.2	5.7	1.4	-1.9	-2.0	-2.4	1.9
Medication: Atenolol	2.3	2.9	8.1	0.1	-1.7	-2.2	-2.8	1.3
High blood pressure (siblings)	2.3	3.3	7.5	1.7	-1.3	-2.7	-2.3	1.5
Diabetes diagnosed by doctor	2.2	3.6	7.8	0.0	-2.6	-2.2	-2.8	1.3
Mean Putamen Volume	2.1	2.4	6.2	2.5	-1.1	-1.9	-1.0	1.6
Medication for pain relief, constipation, heartburn	2.1	3.6	7.6	-0.9	1.6	2.4	2.8	-2.3
Medication: Allopurinol	2.1	2.8	8.5	2.9	-1.2	-0.8	-1.9	1.5
Medication: Paracetamol	2.1	3.2	8.4	1.4	-2.2	-2.9	-1.5	1.3
Number of full brothers	2.0	2.5	4.7	1.0	-2.1	-2.2	-1.8	1.3
Age at first live birth	2.0	3.5	8.5	-2.3	1.8	2.9	1.3	-1.6
Body Mass Index (BMI) (2010)	1.9	2.5	5.4	1.7	-1.2	-1.5	-2.3	1.8
Overall health rating	1.9	4.0	6.4	1.8	-2.0	-2.1	-2.5	2.5
Long-standing illness, disability or infirmity	1.9	2.9	4.5	1.7	-2.1	-1.6	-2.1	1.7
Hearing difficulty/problems: Yes	1.8	2.7	7.7	-1.8	2.8	1.6	1.4	-1.0
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.1	5.7	-2.4	-0.0	1.2	1.5	-1.9
Wheeze or whistling in the chest in last year	1.8	3.1	9.9	0.8	-1.8	-0.3	-3.2	2.2
Alcohol intake versus 10 years previously	1.7	2.6	7.2	1.8	-1.6	-2.7	-1.2	1.1
Maternal smoking around birth	1.6	2.3	5.6	0.2	-2.4	-1.5	-2.1	1.3
Qualifications: CSEs or equivalent	1.6	2.0	3.3	0.6	-1.7	-1.8	-1.8	1.6
Emphysema/chronic bronchitis	1.6	1.8	4.8	0.7	-1.6	-0.9	-2.2	1.5
Illnesses of father: None of the above (group 1)	1.6	2.0	5.2	-0.5	2.3	1.6	2.0	-0.3
Hearing aid user	1.6	1.8	5.3	1.5	-1.7	-2.3	-0.6	-0.0
Diverticular disease/diverticulitis (self-reported)	1.5	1.7	3.0	1.7	-0.7	-1.6	-1.2	1.7
Impedance of leg (left)	1.5	7.1	13.1	-1.1	3.2	3.0	3.6	-3.0
Gout (self-reported)	1.5	2.1	4.4	1.7	-1.7	-1.1	-2.1	1.0
Financial situation satisfaction	1.5	1.8	5.2	0.9	-2.0	-2.3	-1.0	0.2
Vascular/heart problems diagnosed by doctor	1.5	4.2	9.9	-1.5	3.1	2.7	2.1	-1.0
Depressed Affect (Nagel 2018)	1.4	2.9	6.4	0.5	-2.1	-2.5	-2.4	0.3
Glaucoma (self-reported)	1.4	1.7	5.0	-1.1	-0.2	0.5	1.9	-2.2
Heart disease (mother)	1.4	1.7	4.5	-0.2	-1.0	-1.6	-2.1	1.5
Smoking status: Current	1.4	2.2	4.4	0.5	-2.0	-2.1	-1.5	1.4
Mother’s age at death	1.4	1.7	3.8	-0.3	1.9	0.4	1.6	-1.9
Impedance of whole body	1.4	7.3	13.0	-1.4	3.6	3.5	3.3	-2.4
Crohns Disease (2012)	1.3	2.1	3.7	1.6	-1.5	-1.0	-1.9	1.6
Fasting Glucose	1.3	1.6	4.2	1.0	-2.0	-1.1	-1.4	1.1
Ever had hysterectomy (womb removed)	1.3	1.5	3.5	1.4	-1.9	-1.2	1.4	-0.7
Pack years adult smoking proportion	1.3	2.0	3.6	1.9	-1.9	-1.2	-1.5	1.1
Impedance of leg (right)	1.3	6.5	10.5	-0.9	3.1	2.9	3.2	-3.1
Hearing difficulty/problems with background noise	1.3	2.0	5.1	-1.6	0.9	1.4	1.3	-2.2
Medication: Ramipril	1.3	1.7	3.0	1.1	-1.7	-1.1	-1.7	1.4
Reaction Time	1.2	2.3	4.3	-1.4	1.8	1.6	2.1	-1.3
HbA1C	1.2	1.4	3.2	-1.8	1.1	0.6	0.9	-1.6
Taking other prescription medications	1.2	1.8	6.0	0.2	-0.6	-1.2	-2.5	1.7
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.6	-0.7	0.5	1.6	1.4	-1.6
Multivitamins +/- minerals	1.2	1.6	3.5	1.2	-1.1	-0.9	-1.6	1.9
Stomach or abdominal pain in last month	1.2	1.5	3.4	1.3	-0.7	-1.0	-1.6	1.8
Prospective memory result	1.2	1.4	4.8	1.9	0.0	-0.1	-0.4	2.2
Qualifications: College or University degree	1.2	3.8	7.4	-2.7	2.3	2.2	1.7	-1.5
Mean time to correctly identify matches	1.2	2.3	4.4	-1.6	1.9	1.0	2.1	-1.5
Leg pain on walking	1.2	1.5	5.1	0.3	-0.4	-0.3	-1.9	2.3
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	4.2	0.3	-1.0	-0.8	-2.0	1.5
Hypertension (Self-reported)	1.2	3.2	7.5	1.2	-2.7	-2.7	-1.7	0.5
Medication for cholesterol	1.2	1.8	4.3	-0.4	1.9	2.1	1.5	-0.7
Miserableness	1.2	2.0	5.6	-0.2	-1.0	-1.8	-2.4	1.5
Alzheimer’s Disease (including proxy)	1.1	1.6	3.7	1.8	-1.9	-1.5	0.2	0.0
Impedance of arm (right)	1.1	5.2	9.9	-1.6	3.2	3.1	2.4	-1.8
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	5.5	-0.2	-1.5	-1.3	-2.3	1.2
Impedance of arm (left)	1.1	4.9	9.7	-1.6	3.1	3.1	2.3	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	5.3	0.4	-1.8	-2.3	-1.3	0.1
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	4.0	-1.9	0.8	1.2	0.7	-2.0
Medication: Paracetamol	1.1	1.9	4.6	1.2	-1.7	-2.1	-1.0	1.2
Number of full sisters	1.1	1.3	3.5	-1.9	-0.5	-0.6	0.9	-1.8
Irritable Bowel Disease (IBD)	1.0	2.4	3.9	1.8	-2.0	-1.5	-1.6	1.6
Vitamin and mineral supplements	1.0	1.4	3.6	-0.6	0.9	0.9	1.7	-1.9
Current tobacco smoking	1.0	1.7	3.4	0.6	-1.8	-1.9	-1.3	1.2
Shortness of breath walking on level ground	1.0	1.2	3.4	1.2	-1.9	-0.9	-0.8	1.0
Neck or shoulder pain in last month	1.0	1.4	4.6	0.4	-1.4	-0.4	-1.4	2.1
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	4.0	-0.1	2.0	1.5	0.9	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	4.9	-0.2	-0.7	-0.0	-2.2	0.8
Irritability	1.0	1.6	2.7	-1.2	1.3	1.5	1.6	-1.4
Alzheimer’s Disease (in mother)	0.9	1.1	2.8	1.3	-1.7	-1.4	-0.3	-0.3
Crohns Disease (2017)	0.9	2.0	3.0	1.7	-1.6	-0.8	-1.7	1.7
Schizophrenia (2014)	0.9	2.0	5.4	0.6	-2.3	-2.3	-1.0	0.5
Systolic Blood Pressure	0.9	4.3	9.4	2.4	-2.8	-3.1	-1.5	1.0
Smoking Status	0.9	2.2	5.9	0.5	-1.8	-1.3	-2.4	1.4
Fed-up feelings	0.9	1.6	4.6	0.5	-1.7	-1.3	-2.1	0.4
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	3.3	1.8	-1.2	-0.8	-0.7	0.7
Number of incorrect matches in round	0.9	1.4	5.9	1.3	-0.6	-2.4	-0.5	0.6
Time employed in main current job	0.9	1.0	3.5	-0.6	1.3	1.9	0.6	-0.2
Qualifications: A levels/AS levels or equivalent	0.9	2.0	4.8	-2.2	0.8	1.6	0.5	-1.8
Illnesses of mother	0.9	1.1	2.9	0.3	1.3	1.2	1.7	-0.7
Breastfed as a baby	0.9	1.1	2.4	-1.5	0.8	0.9	1.4	-1.0
Medication: Omeprazole	0.9	1.0	2.2	0.3	-0.3	-1.5	-1.3	1.5
Guilty feelings	0.9	1.3	2.6	-0.9	1.0	1.4	1.6	-1.2
Risk taking	0.9	1.4	2.8	-1.1	-1.4	-1.5	-1.7	0.3
Age at First Birth	0.8	1.1	2.9	-1.7	1.2	1.2	-0.3	-1.0
Blood Platelet Count	0.8	9.4	14.7	-2.9	3.1	3.5	3.8	-3.4
BMI	0.8	4.6	13.7	0.7	-0.8	-1.3	-3.7	3.4
Height	0.8	14.6	23.9	-3.3	4.0	4.9	4.2	-4.3
Serious illness, injury or assault to yourself	0.8	1.0	1.9	1.1	-0.6	-1.3	-0.9	1.4
Mouth/teeth dental problems	0.8	1.3	4.3	-2.1	1.0	0.9	-0.2	-1.2
Worrier / anxious feelings	0.8	1.4	4.0	-0.4	0.7	1.4	1.4	-2.0
Pulse rate	0.8	1.4	3.0	1.7	-1.2	-1.0	-1.4	1.1
Exposure to tobacco smoke outside home	0.8	1.1	3.2	-1.4	0.8	0.6	0.4	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.0	-1.0	-1.2	-0.9	-1.4	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	5.2	0.7	2.3	1.5	1.5	0.3
Number of self-reported non-cancer illnesses	0.8	1.3	3.7	0.0	-1.1	-1.5	-1.9	0.9
Medication: Bendroflumethiazide	0.8	1.2	2.7	0.1	-1.4	-1.6	-1.6	0.2
Ever depressed for a whole week	0.8	0.9	2.1	-0.5	0.2	1.2	1.3	-1.4
Unable to work because of sickness or disability	0.8	1.1	2.0	0.8	-0.9	-1.2	-1.3	1.4
Schizophrenia (2018)	0.7	1.5	3.9	0.7	-2.0	-1.9	-0.9	0.2
Blood White Count	0.7	5.0	10.4	1.8	-2.5	-2.4	-3.2	2.1
Lung FEV1/FVC ratio	0.7	3.4	11.0	-2.0	3.3	1.3	1.6	-1.0
Chronotype (morning person)	0.7	1.7	3.8	-0.6	1.1	0.9	1.9	-2.0
Average weekly spirits intake	0.7	0.8	4.3	2.1	0.6	0.1	-0.0	0.5
High blood pressure	0.7	2.0	5.2	0.9	-2.3	-2.2	-1.0	-0.1
Body mass index (BMI)	0.7	2.9	9.0	0.5	-1.0	-1.5	-3.0	2.2
Waist circumference	0.7	2.5	6.6	0.3	-1.0	-1.5	-2.6	2.2
Hair/balding pattern: Pattern 3	0.7	1.0	3.2	0.6	1.8	0.8	1.1	0.7
Standing height	0.7	6.8	13.2	-3.0	2.4	3.6	2.7	-2.4
Worry too long after embarrassment	0.7	1.2	3.5	-1.3	0.0	1.0	1.0	-1.9
Had major operations	0.7	0.8	2.6	0.3	-0.3	-0.6	-1.2	1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	3.6	-1.7	1.4	1.9	0.8	-0.3
Ever had bowel cancer screening	0.7	0.8	2.2	-0.9	1.1	0.0	1.5	-0.9
Pack years of smoking	0.7	1.0	2.7	1.7	-1.3	-0.7	-0.8	0.7
Respiratory disease	0.6	1.3	5.1	0.9	-2.3	-0.2	-1.3	0.5
Relative age of first facial hair	0.6	1.2	3.3	-0.5	0.4	0.6	1.8	-1.7
Hand grip strength (right)	0.6	1.7	5.3	0.6	-0.4	-0.2	2.3	-2.0
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.7	0.5	-1.3	-1.2	-1.0	0.9
Qualifications: None of the above	0.6	1.3	2.4	1.5	-0.9	-1.6	-1.1	1.1
Falls in the last year	0.6	0.9	2.2	0.2	-1.5	-0.8	0.8	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	4.9	-0.2	2.2	2.2	1.3	0.2
Exposure to tobacco smoke at home	0.6	0.7	1.6	0.1	-1.2	-1.2	-0.7	-0.9
Ever highly irritable/argumentative for 2 days	0.6	0.8	2.3	0.8	-1.5	-0.7	-0.4	1.0
Medication: Blood pressure	0.6	1.1	2.2	0.6	-1.3	-1.5	-1.3	0.8
Medication: Seretide 50 evohaler	0.6	0.7	1.3	0.9	0.1	1.1	-0.8	1.1
Alcohol intake frequency.	0.6	1.4	2.9	1.2	-0.6	-1.2	-1.5	1.7
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.2	0.6	-1.1	-0.7	-1.1	1.0
Illnesses of siblings: Diabetes	0.6	0.7	2.6	0.8	-0.4	-0.6	-1.6	0.8
Eye problems/disorders: Cataract	0.6	0.7	2.8	1.0	0.1	-1.7	-0.1	0.8
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.0	1.1	-0.7	-0.8	-1.1	1.4
Average weekly champagne plus white wine intake	0.6	0.8	2.1	0.2	1.5	1.4	0.7	0.6
Tinnitus: Yes, now most or all of the time	0.6	0.6	3.4	-1.8	0.2	-0.6	-0.2	-0.1
Number of operations (self-reported)	0.6	0.8	2.1	-0.0	-0.2	-1.4	-1.0	1.4
Fractured/broken bones in last 5 years	0.6	0.8	1.9	-1.3	0.2	1.4	0.5	-0.8
Alzheimer’s Disease (in father)	0.5	0.6	1.4	0.2	-1.2	-0.8	-0.6	0.9
Ulcerative Colitis (UC)	0.5	1.0	3.2	0.8	-1.8	-1.2	-0.7	0.4
Major Depression (MDD)	0.5	0.6	1.2	-0.7	-1.1	-0.6	-0.7	-0.9
Ovarian Cancer	0.5	0.6	1.3	-1.1	-0.3	-0.2	1.1	-1.1
Ulcerative Colitis	0.5	0.7	2.1	0.9	-1.1	-1.5	-0.5	0.3
Blood Red Count	0.5	4.4	9.4	2.6	-1.7	-1.5	-2.2	3.1
Lung FVC	0.5	2.3	6.5	2.6	-2.0	-1.6	-0.1	0.9
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.7	-0.4	-0.3	-0.8	-1.3	0.6
Medication for hormone replacement therapy	0.5	0.6	1.7	1.3	-0.1	-0.9	-0.5	0.7
Severe depression (siblings)	0.5	0.5	1.7	-0.5	-0.4	0.7	0.8	-1.3
Had other major operations	0.5	0.6	1.7	0.3	-0.3	-1.3	-0.8	0.9
Arm fat percentage (right)	0.5	2.0	7.0	0.2	0.1	-0.3	-2.7	2.2
Lung cancer (father)	0.5	0.5	1.6	-0.1	0.1	1.3	0.6	-1.1
Pulse wave Arterial Stiffness index	0.5	0.6	1.5	-0.1	-0.8	0.8	-0.7	1.2
Pulse wave reflection index	0.5	0.6	2.0	-0.6	0.9	1.4	0.1	0.4
Forced vital capacity (FVC), Best measure	0.5	1.7	5.2	0.1	1.8	2.3	1.2	-0.1
Pulse wave peak to peak time	0.5	0.6	1.8	0.2	0.7	-0.7	0.8	-1.3
Pulse rate, automated reading	0.5	1.6	2.7	1.5	-1.6	-1.3	-1.6	0.7
Age at last live birth	0.5	0.7	3.0	-1.7	0.1	0.6	-0.2	-0.8
Arm fat percentage (left)	0.5	2.0	7.2	0.1	0.3	-0.1	-2.7	2.2
Friendships satisfaction	0.5	0.6	1.8	0.2	-0.4	-0.7	-1.3	1.0
Qualifications: nursing, teaching	0.5	0.8	1.8	-0.9	0.7	0.9	1.0	-1.3
Arm fat mass (left)	0.5	1.9	7.2	-0.0	0.0	-0.4	-2.7	1.9
Pain type(s) experienced in last month: Hip pain	0.5	0.7	2.0	-0.0	0.4	-0.6	-1.3	1.4
Alcohol drinker status: Previous	0.5	0.6	2.3	-0.3	0.6	1.5	-0.5	0.8
Bipolar Disorder (2018)	0.4	0.6	2.3	-0.6	0.0	-0.1	0.9	-1.5
Bipolar Disorder or Schizophrenia	0.4	0.9	2.3	0.2	-1.5	-1.5	-0.3	-0.8
Worry (Nagel 2018)	0.4	0.7	3.0	1.7	-0.6	-0.1	0.7	-0.8
Breast Cancer	0.4	0.9	3.2	0.1	-1.0	-1.8	-1.0	-0.0
LDL Cholesterol	0.4	0.6	1.9	-0.2	0.7	0.2	-1.0	1.4
Neuroticism (2016)	0.4	0.5	1.3	-0.7	-1.0	-0.3	-0.4	-1.1
Hand grip strength (left)	0.4	1.1	2.4	0.9	-1.2	0.0	1.3	-1.6
Supplements: Zinc	0.4	0.5	1.0	0.6	-0.8	-1.0	-0.9	0.1
Diabetes (father)	0.4	0.5	0.8	-0.9	-0.8	-0.9	-0.7	-0.1
Diabetes (mother)	0.4	0.5	1.1	-1.0	0.7	1.0	0.2	-0.7
Past tobacco smoking	0.4	0.7	2.2	0.4	1.2	0.4	1.5	-0.4
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.7	-0.4	0.0	0.3	0.7	-1.3
Pain all over the body in last month	0.4	0.4	1.0	-0.9	-0.9	0.3	-1.0	0.3
Happiness	0.4	0.5	1.6	1.3	-0.1	-0.3	-0.4	1.0
Depression (self-reported)	0.4	0.5	2.1	-0.5	1.5	0.3	-0.8	-0.0
Hair/balding pattern: Pattern 4	0.4	1.0	5.2	-0.6	0.3	0.4	0.5	-2.3
Birth weight of first child	0.4	0.6	1.2	0.9	-0.7	-1.1	-0.6	1.1
Peak expiratory flow (PEF)	0.4	0.8	2.4	-0.5	1.4	1.6	0.0	0.6
Loud music exposure frequency	0.4	0.5	1.1	-1.1	0.6	1.1	-0.0	-0.4
Medication: Amlodipine	0.4	0.6	1.2	-0.4	-1.1	-0.5	-1.1	0.6
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.2	0.1	-1.1	0.0	-0.5	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.3	-0.2	-0.9	-1.1	-0.5	-1.0
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.6	1.2	-0.4	-1.0	-0.5	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.3	-0.5	0.9	1.1	0.2	0.5
Average weekly red wine intake	0.4	0.5	0.9	-0.7	0.7	0.7	0.9	-0.9
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.3	1.1	-1.1	-0.3	0.4	0.1
Mood swings	0.4	0.8	2.4	0.3	-1.2	-1.5	-0.9	0.3
Loneliness, isolation	0.4	0.6	2.3	-0.4	-0.2	-0.4	-1.5	0.8
Breast cancer (self-reported)	0.4	0.4	1.0	-1.0	0.7	0.9	0.5	-0.3
Medication: Gliclazide	0.4	0.5	2.6	0.0	0.0	-0.4	-1.6	0.5
Illnesses of father: High blood pressure	0.4	0.5	1.1	-1.1	-0.6	-0.9	0.5	-0.7
Myopia	0.4	0.5	1.4	0.6	-0.6	-0.6	-0.9	1.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.5	0.9	-0.8	-1.2	-0.1	-0.3
Neuroticism (Nagel 2018)	0.3	0.6	1.6	0.4	-1.1	-0.7	-0.3	-1.3
Prostate Cancer	0.3	0.5	1.0	-1.0	1.0	0.6	0.3	-0.7
Lupus	0.3	0.5	1.6	1.1	0.4	-0.3	0.2	1.3
Rheumatoid Arthritis	0.3	0.5	1.2	-1.1	-0.6	-0.9	0.2	-0.6
Sensitivity / hurt feelings	0.3	0.5	1.1	-0.9	0.4	1.0	0.1	-1.0
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.3	-0.1	-0.6	-0.7	-1.1	0.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.6	0.6	-0.8	-1.2	0.0	0.3
Medication: Co-codamol	0.3	0.3	1.1	0.6	0.5	-0.4	-0.3	1.0
Leg fat-free mass (left)	0.3	1.3	4.4	-0.7	-0.8	-0.3	-2.1	1.5
Trunk fat percentage	0.3	1.4	3.3	-0.9	1.8	1.4	-1.1	1.0
Average weekly fortified wine intake	0.3	0.3	0.9	-0.5	1.0	0.8	0.2	-0.2
Relative age voice broke	0.3	0.5	2.1	0.1	0.8	0.3	1.4	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.4	-0.4	-1.2	-0.9	-0.8	-0.6
High blood pressure (mother)	0.3	0.4	1.8	-1.4	0.6	-0.0	0.0	-0.3
Leg predicted mass (left)	0.3	1.4	4.6	-0.8	-0.9	-0.3	-2.1	1.5
Trunk fat mass	0.3	1.1	1.7	-1.0	1.3	1.1	-1.3	1.0
Nervous feelings	0.3	0.5	1.7	0.7	-0.0	0.2	1.3	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.8	-0.6	-1.3	-1.2	-0.8	-0.4
Mouth/teeth dental problems: Dentures	0.3	0.6	2.3	0.8	0.5	0.2	1.5	-0.5
Arm fat mass (right)	0.3	1.4	5.2	-0.1	0.0	-0.3	-2.3	1.7
Length of working week for main job	0.3	0.3	0.9	-0.1	0.9	0.3	0.8	0.5
Blood clot in the leg (DVT)	0.3	0.4	1.0	0.8	-0.6	-1.0	0.2	-0.6
Medication: Ventolin 100micrograms inhaler	0.3	0.3	1.3	-0.1	-0.5	0.5	-0.5	1.1
Birth weight	0.3	0.7	1.9	0.2	0.7	1.1	1.4	-0.5
Comparative body size at age 10	0.3	0.8	3.5	0.1	0.3	1.1	0.2	-1.9
Eye problems/disorders: None of the above	0.3	0.3	1.2	-0.4	0.2	1.1	0.0	0.6
Leg fat-free mass (right)	0.3	1.5	4.1	-0.9	-1.1	-0.3	-2.0	1.6
Osteoarthritis (self-reported)	0.3	0.4	2.0	-1.4	0.3	-0.1	-0.3	0.2
Leg predicted mass (right)	0.3	1.5	4.3	-0.9	-1.1	-0.3	-2.1	1.7
Ever smoked	0.3	0.5	1.3	-0.8	-1.0	0.1	-1.1	0.2
Supplements: Calcium	0.3	0.4	1.0	-0.9	0.4	0.0	0.6	-1.0
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.0	-1.4	0.3	-0.1	0.4	-1.3
Heel T-Score	0.2	1.3	3.0	0.3	-1.7	-1.7	-1.3	0.1
Neuroticism	0.2	0.5	1.8	-0.1	-0.7	-0.6	0.2	-1.3
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.6	-0.2	0.4	-0.5	0.6	-0.8
Systolic blood pressure, automated reading	0.2	0.7	2.6	0.6	-1.0	-1.6	0.2	-0.6
Age when periods started (menarche)	0.2	0.4	1.2	0.8	-0.1	0.4	-1.1	0.4
Medication: Levothyroxine sodium	0.2	0.3	1.2	-0.2	-1.1	-0.2	-0.3	-0.4
Alcohol usually taken with meals	0.2	0.3	1.2	-0.6	1.1	-0.2	0.7	-0.1
Fluid intelligence score	0.2	0.4	1.0	-0.2	-1.0	-0.6	-0.9	-0.4
Weight	0.2	0.7	2.8	-0.8	-0.0	0.1	-1.7	1.0
Number of live births	0.2	0.2	1.2	-0.4	0.1	-1.1	0.1	0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.5	-0.1	1.4	1.6	0.3	0.6
Medication: Lansoprazole	0.2	0.2	0.9	0.5	-0.9	-0.3	-0.2	0.1
Tense / ‘highly strung’	0.2	0.4	1.2	0.7	-0.9	-1.1	-0.2	0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.0	-0.9	-0.5	-0.2	-0.8	-1.0
Body fat percentage	0.2	0.9	1.9	-0.4	1.3	0.8	-1.4	1.1
Migraine (self-reported)	0.2	0.2	0.7	0.2	0.8	0.7	0.5	-0.1
Whole body fat mass	0.2	0.8	2.2	-0.5	0.8	0.4	-1.5	1.2
Leg fat mass (right)	0.2	0.7	3.1	-0.2	0.4	-0.2	-1.8	1.1
Comparative height size at age 10	0.2	1.3	3.5	-1.9	0.8	1.8	0.5	-0.6
Knee pain experienced in last month	0.2	0.3	0.9	-0.4	0.5	0.8	-0.2	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.8	0.9	-0.6	-0.1	-0.3	0.3
Smoking status: Previous	0.2	0.3	1.2	-0.4	0.2	1.1	-0.6	-0.3
Commuting to job workplace: Walk	0.2	0.3	0.9	-0.2	0.7	1.0	0.1	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.6	-0.1	-0.2	-0.7	0.7	-0.8
Back pain experienced in last month	0.2	0.3	0.7	-0.2	0.9	0.2	-0.5	0.8
Mineral and other dietary supplements	0.2	0.3	0.8	0.5	-0.2	0.4	-0.9	0.8
Osteoporosis (self-reported)	0.2	0.3	1.3	-0.2	0.0	-0.1	-0.6	1.1
Medication: Blood pressure	0.2	0.4	1.0	0.1	-1.0	-0.9	-0.4	-0.1
Basal cell carcinoma (self-reported)	0.2	0.3	0.7	0.6	-0.3	-0.8	-0.6	0.3
Leg fat mass (left)	0.2	0.7	2.5	-0.3	0.5	-0.0	-1.6	1.1
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.8	-0.9	-0.2	0.2	-0.2	-0.2
Bipolar Disorder (2011)	0.1	0.1	0.5	-0.2	0.7	-0.1	0.2	-0.1
Primary Biliary Cirrhosis	0.1	0.2	0.7	-0.4	-0.3	-0.8	-0.0	-0.2
Allergy or Eczema	0.1	0.2	0.5	-0.7	0.2	0.7	-0.4	0.0
Hypothyroidism (self reported)	0.1	0.3	0.7	-0.8	-0.5	0.2	-0.8	-0.6
Hair Pigment	0.1	1.7	4.7	1.9	-1.3	-2.2	-0.2	-0.3
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.9	-0.2	0.5	1.0	-0.1	0.3
Supplements: Glucosamine	0.1	0.2	0.5	-0.7	-0.4	-0.4	0.3	0.3
Forced vital capacity (FVC)	0.1	0.6	2.0	0.3	1.0	1.4	0.1	0.6
Allergy	0.1	0.3	1.0	0.6	-0.2	-1.0	0.5	-0.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.4	0.1	0.2	0.6	0.1	0.3
Neuroticism score	0.1	0.2	1.1	-0.1	-0.3	0.1	0.2	-1.1
Trunk fat-free mass	0.1	0.4	1.1	-0.8	-1.1	-0.3	-0.7	0.1
Hip circumference	0.1	0.5	1.5	-0.7	1.2	0.9	-0.1	0.3
Noisy workplace	0.1	0.1	0.2	0.4	0.4	0.5	-0.2	0.3
Asthma	0.1	0.3	0.7	-0.2	-0.6	0.6	-0.8	0.6
Trunk predicted mass	0.1	0.4	1.0	-0.8	-1.0	-0.2	-0.7	0.1
Headache pain in last month	0.1	0.1	0.4	-0.5	-0.1	-0.6	-0.4	0.2
Leg fat percentage (right)	0.1	0.4	1.4	-0.1	0.9	0.1	-1.2	0.5
Number of children fathered	0.1	0.2	0.6	-0.8	-0.5	-0.2	0.1	-0.2
Arm predicted mass (right)	0.1	0.3	0.8	-0.5	-0.6	-0.3	-0.9	0.4
Suffer from ‘nerves’	0.1	0.2	1.0	1.0	-0.3	-0.2	-0.1	0.4
Family relationship satisfaction	0.1	0.1	0.5	0.1	-0.1	0.3	0.7	-0.1
Supplements: Vitamin C	0.1	0.1	0.4	-0.6	0.4	0.3	-0.4	-0.1
Whole body fat-free mass	0.1	0.7	1.9	-0.7	-1.1	-0.4	-1.4	0.8
Asthma (self-reported)	0.1	0.3	0.7	-0.2	-0.7	0.4	-0.9	0.6
Whole body water mass	0.1	0.6	1.6	-0.7	-1.0	-0.4	-1.2	0.7
Ever taken oral contraceptive pill	0.1	0.1	0.3	0.3	0.0	0.6	0.1	0.2
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.1	0.2	0.5	-0.5	0.2
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.4	-0.6	0.2	-0.0	0.0	-0.7
Alcohol drinker status: Never	0.1	0.1	0.2	-0.2	0.4	-0.2	-0.4	0.5
Basal metabolic rate	0.1	0.7	2.3	-0.8	-0.8	-0.3	-1.5	0.9
Leg fat percentage (left)	0.1	0.4	1.0	-0.3	1.0	0.3	-1.0	0.6
Arm fat-free mass (left)	0.1	0.3	0.8	-0.6	-0.7	-0.5	-0.9	0.3
Diastolic blood pressure, automated reading	0.1	0.2	0.7	0.9	-0.3	-0.5	0.1	0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.4	-0.6	0.3	-0.4	-0.1	0.5
Pain experienced in last month	0.1	0.1	0.2	0.4	-0.1	-0.4	-0.3	-0.2
Arm predicted mass (left)	0.1	0.3	0.8	-0.5	-0.9	-0.6	-0.7	0.3
Schizophrenia vs Biploar Disorder	0.0	0.1	0.2	-0.3	-0.2	-0.1	-0.1	0.4
Tanning	0.0	0.3	0.9	-0.6	-0.0	0.4	-1.0	0.4
Sitting height	0.0	0.2	0.5	-0.2	-0.7	0.4	-0.4	0.3
Arm fat-free mass (right)	0.0	0.2	0.6	-0.7	-0.5	-0.2	-0.8	0.2
Medication: Lisinopril	0.0	0.0	0.2	0.2	-0.1	-0.0	-0.0	-0.4
Average weekly beer plus cider intake	0.0	0.1	0.2	-0.3	-0.1	-0.5	0.2	-0.2

Hub : Genes

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Trait associations