Hub : Traits :

Angina (self-reported)

34 significantly associated models · 15 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 109098737 110517617 2 1 4.0e-13 3.9e-13 1.0e+00 100 PSRC1
2 1 222133118 223529093 1 1 9.5e-08 1.8e-06 7.6e-01 100 RP11-378J18.8
3 6 12020241 13990267 2 1 2.0e-08 1.9e-08 1.1e-01 92 PHACTR1
4 6 159843841 161571560 2 1 6.6e-09 9.1e-17 5.0e-15 11 SLC22A3
5 9 21303958 22819407 2 2 3.2e-22 8.6e-34 7.5e-14 62 CDKN2B CDKN2B-AS1
6 15 77888924 79802863 3 2 3.3e-11 1.9e-10 2.4e-01 97 ADAMTS7
7 15 90718541 92135418 2 1 3.4e-10 1.2e-08 8.5e-01 100 FES
8 20 62018747 62912463 1 1 3.5e-07 9.5e-07 4.9e-01 98 C20orf201

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 0.94 1 0 0.0 0.00 1.0e+00 FES
Irritable Bowel Disease (IBD) 1.00 1 0 0.0 0.00 1.0e+00 FES
Ulcerative Colitis (UC) 1.34 1 0 0.0 0.00 1.0e+00 C20orf201
Major Depression (MDD) 2.94 1 0 0.0 0.00 1.0e+00 FES
Breast Cancer 2.96 3 0 0.0 0.00 1.0e+00 CDKN2B CDKN2B-AS1 FES
Coronary Artery Disease (CAD) 29.14 7 5 15.2 -0.98 1.1e-05 ADAMTS7 CDKN2B CDKN2B-AS1 FES PHACTR1 PSRC1 SLC22A3
HDL Cholesterol 2.49 1 1 3.0 0.00 1.0e+00 PSRC1
LDL Cholesterol 56.68 1 1 3.0 0.00 1.0e+00 PSRC1
Rheumatoid Arthritis 2.39 1 0 0.0 0.00 1.0e+00 C20orf201
Schizophrenia 2.77 1 1 3.0 0.00 1.0e+00 FES
Type 2 Diabetes (T2D) 3.93 1 0 0.0 0.00 1.0e+00 CDKN2B
Blood Platelet Count 0.84 3 1 3.0 -0.97 2.7e-02 ADAMTS7 CDKN2B SLC22A3
Blood Red Count 0.43 1 0 0.0 0.00 1.0e+00 FES
Blood White Count 1.56 3 1 3.0 0.00 1.0e+00 C20orf201 CDKN2B FES
Heel T-Score 0.42 1 0 0.0 0.00 1.0e+00 PSRC1
BMI 0.98 1 0 0.0 0.00 1.0e+00 SLC22A3
Height 0.75 3 3 9.1 0.00 1.0e+00 FES PSRC1 SLC22A3
Waist Hip Ratio (WHR) 3.07 3 2 6.1 0.00 1.0e+00 ADAMTS7 C20orf201 SLC22A3
Systolic Blood Pressure 8.35 5 3 9.1 -0.59 3.0e-01 ADAMTS7 C20orf201 FES PHACTR1 SLC22A3
Smoking Status 2.06 2 0 0.0 0.00 1.0e+00 FES PSRC1
Allergy or Eczema 1.58 1 0 0.0 0.00 1.0e+00 FES
Cardiovascular Disease 10.32 4 3 9.1 -0.98 2.3e-02 C20orf201 FES PSRC1 SLC22A3
Respiratory disease 1.54 1 0 0.0 0.00 1.0e+00 FES
Type 2 Diabetes (T2D) 2.10 1 0 0.0 0.00 1.0e+00 SLC22A3
Lung FEV1/FVC ratio 0.98 2 1 3.0 0.00 1.0e+00 PSRC1 RP11-378J18.8
Lung FVC 1.02 1 1 3.0 0.00 1.0e+00 C20orf201
Neuroticism 0.94 1 0 0.0 0.00 1.0e+00 FES
Hair Pigment 0.58 5 3 9.1 0.79 1.1e-01 ADAMTS7 C20orf201 CDKN2B CDKN2B-AS1 FES
Hand grip strength (left) 2.03 2 0 0.0 0.00 1.0e+00 FES PHACTR1
Number of treatments/medications taken 3.33 2 1 3.0 0.00 1.0e+00 FES PSRC1
Sensitivity / hurt feelings 1.64 1 0 0.0 0.00 1.0e+00 FES
Hearing difficulty/problems: Yes 1.67 1 0 0.0 0.00 1.0e+00 PSRC1
Other serious medical condition/disability diagnosed by doctor 1.05 1 0 0.0 0.00 1.0e+00 PSRC1
Systolic blood pressure, automated reading 6.50 3 1 3.0 0.00 1.0e+00 C20orf201 FES PHACTR1
Angina 34.66 9 9 27.3 1.00 3.4e-14 ADAMTS7 C20orf201 CDKN2B CDKN2B-AS1 FES PHACTR1 PSRC1 RP11-378J18.8 SLC22A3
Vitamin and mineral supplements 1.87 1 0 0.0 0.00 1.0e+00 ADAMTS7
Medication: Metformin 2.14 1 0 0.0 0.00 1.0e+00 CDKN2B
Pack years adult smoking proportion 8.16 1 1 3.0 0.00 1.0e+00 ADAMTS7
Impedance of leg (right) 1.54 2 1 3.0 0.00 1.0e+00 C20orf201 FES
Leg fat-free mass (left) 1.28 4 0 0.0 -0.99 1.2e-02 C20orf201 FES PSRC1 SLC22A3
Trunk fat percentage 1.16 1 0 0.0 0.00 1.0e+00 SLC22A3
Hand grip strength (right) 1.41 1 0 0.0 0.00 1.0e+00 PHACTR1
High blood pressure 6.87 3 1 3.0 0.00 1.0e+00 C20orf201 FES PHACTR1
Hayfever, allergic rhinitis or eczema 1.69 1 0 0.0 0.00 1.0e+00 FES
Multivitamins +/- minerals 2.23 1 0 0.0 0.00 1.0e+00 ADAMTS7
Medication: Atenolol 7.43 2 1 3.0 0.00 1.0e+00 CDKN2B FES
Sitting height 0.82 2 0 0.0 0.00 1.0e+00 ADAMTS7 SLC22A3
Chronic bronchitis/emphysema (father) 4.11 1 0 0.0 0.00 1.0e+00 ADAMTS7
High blood pressure (mother) 6.78 2 1 3.0 0.00 1.0e+00 FES PHACTR1
Impedance of leg (left) 1.48 2 1 3.0 0.00 1.0e+00 C20orf201 FES
Leg predicted mass (left) 1.29 4 0 0.0 -0.99 9.7e-03 C20orf201 FES PSRC1 SLC22A3
Trunk fat mass 1.19 1 0 0.0 0.00 1.0e+00 SLC22A3
Number of incorrect matches in round 1.31 1 0 0.0 0.00 1.0e+00 FES
Past tobacco smoking 1.96 1 0 0.0 0.00 1.0e+00 CDKN2B-AS1
Alcohol usually taken with meals 2.00 1 0 0.0 0.00 1.0e+00 FES
Forced vital capacity (FVC) 0.93 1 0 0.0 0.00 1.0e+00 C20orf201
Heart attack 26.05 8 7 21.2 0.98 2.7e-05 ADAMTS7 CDKN2B CDKN2B-AS1 FES PHACTR1 PSRC1 RP11-378J18.8 SLC22A3
Allergy 1.64 1 0 0.0 0.00 1.0e+00 FES
Medication: Ramipril 4.65 2 0 0.0 0.00 1.0e+00 FES SLC22A3
Medication: Simvastatin 18.61 7 3 9.1 0.90 5.1e-03 C20orf201 CDKN2B CDKN2B-AS1 FES PSRC1 RP11-378J18.8 SLC22A3
Illnesses of siblings 3.31 1 0 0.0 0.00 1.0e+00 FES
Weight 1.09 1 0 0.0 0.00 1.0e+00 SLC22A3
Impedance of arm (right) 1.00 2 0 0.0 0.00 1.0e+00 C20orf201 CDKN2B
Arm fat percentage (right) 1.22 1 0 0.0 0.00 1.0e+00 SLC22A3
Trunk fat-free mass 1.25 3 1 3.0 0.00 1.0e+00 C20orf201 PSRC1 SLC22A3
Hip circumference 1.50 2 1 3.0 0.00 1.0e+00 ADAMTS7 SLC22A3
Father's age at death 7.19 4 1 3.0 -0.99 5.1e-03 CDKN2B CDKN2B-AS1 FES PSRC1
Number of live births 1.12 1 0 0.0 0.00 1.0e+00 FES
Forced expiratory volume in 1-second (FEV1) 0.87 1 0 0.0 0.00 1.0e+00 C20orf201
Asthma 1.04 1 0 0.0 0.00 1.0e+00 FES
Medication: Ibuprofen (e.g. Nurofen) 4.39 2 1 3.0 0.00 1.0e+00 PHACTR1 SLC22A3
Medication: Cholesterol lowering 25.86 7 3 9.1 0.90 5.5e-03 C20orf201 CDKN2B CDKN2B-AS1 FES PSRC1 RP11-378J18.8 SLC22A3
Lung cancer (father) 5.59 1 0 0.0 0.00 1.0e+00 ADAMTS7
Illnesses of mother 5.07 2 1 3.0 0.00 1.0e+00 CDKN2B FES
Pulse wave Arterial Stiffness index 3.72 2 0 0.0 0.00 1.0e+00 FES PHACTR1
Impedance of arm (left) 0.89 1 0 0.0 0.00 1.0e+00 C20orf201
Arm fat mass (right) 1.11 1 0 0.0 0.00 1.0e+00 SLC22A3
Trunk predicted mass 1.23 3 1 3.0 0.00 1.0e+00 C20orf201 PSRC1 SLC22A3
Standing height 0.70 2 1 3.0 0.00 1.0e+00 PSRC1 SLC22A3
Breastfed as a baby 1.46 1 0 0.0 0.00 1.0e+00 FES
Hair/balding pattern: Pattern 4 1.27 1 0 0.0 0.00 1.0e+00 FES
Birth weight of first child 4.10 2 1 3.0 0.00 1.0e+00 C20orf201 FES
Medication: Paracetamol 2.39 1 1 3.0 0.00 1.0e+00 PHACTR1
Headache pain in last month 4.67 2 1 3.0 0.00 1.0e+00 FES PHACTR1
Medication for cholesterol, blood pressure or diabetes 12.63 4 3 9.1 -0.97 3.4e-02 C20orf201 FES PSRC1 RP11-378J18.8
Glaucoma (self-reported) 6.87 2 1 3.0 0.00 1.0e+00 CDKN2B CDKN2B-AS1
Medication: Amlodipine 3.19 1 1 3.0 0.00 1.0e+00 FES
Birth weight 2.39 1 1 3.0 0.00 1.0e+00 FES
Chronic bronchitis/emphysema (mother) 3.03 1 0 0.0 0.00 1.0e+00 ADAMTS7
High blood pressure (siblings) 3.37 1 1 3.0 0.00 1.0e+00 FES
Body fat percentage 1.12 1 0 0.0 0.00 1.0e+00 SLC22A3
Leg fat percentage (right) 1.04 1 0 0.0 0.00 1.0e+00 RP11-378J18.8
Arm fat-free mass (right) 1.08 3 0 0.0 0.00 1.0e+00 C20orf201 PSRC1 SLC22A3
Pulse wave peak to peak time 3.72 2 0 0.0 0.00 1.0e+00 FES PHACTR1
Medication for pain relief, constipation, heartburn 2.63 2 0 0.0 0.00 1.0e+00 PHACTR1 PSRC1
Medication: Blood pressure 6.20 2 1 3.0 0.00 1.0e+00 C20orf201 FES
Migraine (self-reported) 5.55 1 1 3.0 0.00 1.0e+00 PHACTR1
Medication: Ibuprofen 4.46 2 1 3.0 0.00 1.0e+00 PHACTR1 SLC22A3
Mean time to correctly identify matches 1.38 1 0 0.0 0.00 1.0e+00 FES
Heart disease (mother) 15.31 7 3 9.1 0.98 3.7e-05 ADAMTS7 CDKN2B CDKN2B-AS1 FES PHACTR1 RP11-378J18.8 SLC22A3
Whole body fat mass 1.15 1 0 0.0 0.00 1.0e+00 SLC22A3
Leg fat mass (right) 0.93 1 0 0.0 0.00 1.0e+00 SLC22A3
Arm predicted mass (right) 1.08 3 0 0.0 0.00 1.0e+00 C20orf201 PSRC1 SLC22A3
Pulse rate, automated reading 1.50 1 0 0.0 0.00 1.0e+00 RP11-378J18.8
Alcohol intake frequency. 1.63 1 0 0.0 0.00 1.0e+00 PHACTR1
Comparative height size at age 10 1.02 3 0 0.0 0.00 1.0e+00 FES PSRC1 SLC22A3
Chest pain or discomfort 3.35 1 0 0.0 0.00 1.0e+00 CDKN2B
Medication: Aspirin 16.91 6 5 15.2 0.99 2.6e-04 C20orf201 CDKN2B CDKN2B-AS1 FES PSRC1 SLC22A3
Knee pain experienced in last month 1.60 1 0 0.0 0.00 1.0e+00 PHACTR1
Hypertension (Self-reported) 7.01 4 1 3.0 0.65 3.5e-01 C20orf201 FES PHACTR1 SLC22A3
Illnesses of father: Heart disease 30.54 9 7 21.2 0.99 5.8e-08 ADAMTS7 C20orf201 CDKN2B CDKN2B-AS1 FES PHACTR1 PSRC1 RP11-378J18.8 SLC22A3
Smoking status: Previous 1.77 1 0 0.0 0.00 1.0e+00 CDKN2B-AS1
Whole body fat-free mass 1.23 4 0 0.0 -1.00 2.0e-03 C20orf201 FES PSRC1 SLC22A3
Leg fat-free mass (right) 1.30 3 0 0.0 0.00 1.0e+00 FES PSRC1 SLC22A3
Arm fat percentage (left) 1.08 1 0 0.0 0.00 1.0e+00 PHACTR1
Handedness (chirality/laterality): Left-handed 1.93 1 0 0.0 0.00 1.0e+00 FES
Long-standing illness, disability or infirmity 1.88 1 0 0.0 0.00 1.0e+00 CDKN2B
Diabetes diagnosed by doctor 2.12 1 0 0.0 0.00 1.0e+00 SLC22A3
Medication for cholesterol 7.03 4 2 6.1 -0.99 8.2e-03 C20orf201 FES PSRC1 SLC22A3
Breast cancer (self-reported) 3.15 1 0 0.0 0.00 1.0e+00 CDKN2B
Asthma (self-reported) 1.06 1 0 0.0 0.00 1.0e+00 FES
Medication: Aspirin 16.55 6 5 15.2 0.99 2.5e-04 C20orf201 CDKN2B CDKN2B-AS1 FES PSRC1 SLC22A3
Illnesses of father: None of the above (group 1) 10.51 4 2 6.1 -0.99 1.4e-02 CDKN2B CDKN2B-AS1 FES SLC22A3
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.42 2 0 0.0 0.00 1.0e+00 ADAMTS7 C20orf201
Whole body water mass 1.22 4 0 0.0 -1.00 1.1e-03 C20orf201 FES PSRC1 SLC22A3
Leg predicted mass (right) 1.31 3 0 0.0 0.00 1.0e+00 FES PSRC1 SLC22A3
Arm fat mass (left) 1.09 1 0 0.0 0.00 1.0e+00 SLC22A3
Number of self-reported non-cancer illnesses 3.49 2 0 0.0 0.00 1.0e+00 C20orf201 PSRC1
Eye problems/disorders: Glaucoma 9.06 2 2 6.1 0.00 1.0e+00 CDKN2B CDKN2B-AS1
Medication: Blood pressure 6.68 4 1 3.0 0.75 2.5e-01 ADAMTS7 C20orf201 FES SLC22A3
Supplements: Fish oil (including cod liver oil) 2.34 1 0 0.0 0.00 1.0e+00 SLC22A3
High cholesterol (Self-reported) 28.40 5 3 9.1 0.86 6.1e-02 C20orf201 FES PSRC1 RP11-378J18.8 SLC22A3
Medication: Bendroflumethiazide 4.28 2 1 3.0 0.00 1.0e+00 ADAMTS7 FES
Medication: Paracetamol 2.04 1 0 0.0 0.00 1.0e+00 PHACTR1
Medication: Lisinopril 2.17 1 0 0.0 0.00 1.0e+00 FES
Medication: Atorvastatin 18.46 5 2 6.1 0.97 6.9e-03 C20orf201 CDKN2B CDKN2B-AS1 PSRC1 SLC22A3
Illnesses of father: High blood pressure 4.56 1 1 3.0 0.00 1.0e+00 FES
Ever smoked 1.51 1 0 0.0 0.00 1.0e+00 FES
Basal metabolic rate 1.20 4 0 0.0 -1.00 3.1e-03 C20orf201 FES PSRC1 SLC22A3
Arm fat-free mass (left) 1.01 3 0 0.0 0.00 1.0e+00 C20orf201 PSRC1 SLC22A3
Risk taking 2.32 1 0 0.0 0.00 1.0e+00 FES
Age started oral contraceptive pill 1.19 1 0 0.0 0.00 1.0e+00 FES
Diastolic blood pressure, automated reading 6.91 4 2 6.1 -0.15 8.1e-01 ADAMTS7 CDKN2B CDKN2B-AS1 FES
Vascular/heart problems diagnosed by doctor 8.55 4 2 6.1 -0.92 8.4e-02 C20orf201 CDKN2B FES SLC22A3
Cholesterol lowering medication 16.10 4 3 9.1 0.91 8.7e-02 C20orf201 CDKN2B PSRC1 SLC22A3
Pain experienced in last month 1.77 1 0 0.0 0.00 1.0e+00 PHACTR1
Basal cell carcinoma (self-reported) 3.50 1 0 0.0 0.00 1.0e+00 CDKN2B
Heart attack/myocardial infarction (self-reported) 26.45 8 7 21.2 0.98 3.4e-05 ADAMTS7 CDKN2B CDKN2B-AS1 FES PHACTR1 PSRC1 RP11-378J18.8 SLC22A3
Heart disease (siblings) 11.49 7 0 0.0 0.96 7.1e-04 ADAMTS7 CDKN2B CDKN2B-AS1 FES PHACTR1 PSRC1 SLC22A3
Pack years of smoking 7.23 1 1 3.0 0.00 1.0e+00 ADAMTS7
Impedance of whole body 1.17 2 1 3.0 0.00 1.0e+00 C20orf201 PSRC1
Leg fat mass (left) 0.83 1 0 0.0 0.00 1.0e+00 SLC22A3
Arm predicted mass (left) 1.11 3 0 0.0 0.00 1.0e+00 C20orf201 PSRC1 SLC22A3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.33
GTEx Adipose Visceral Omentum 1 0.0491 1.28
GTEx Adrenal Gland 0 0.0000 1.36
GTEx Artery Aorta 2 0.0672 1.40
GTEx Artery Coronary 0 0.0000 1.33
GTEx Artery Tibial 4 0.1064 1.38
GTEx Brain Caudate basal ganglia 0 0.0000 1.28
GTEx Brain Cerebellar Hemisphere 1 0.0672 1.32
GTEx Brain Cerebellum 0 0.0000 1.34
GTEx Brain Cortex 0 0.0000 1.40
GTEx Brain Frontal Cortex BA9 0 0.0000 1.38
GTEx Brain Hippocampus 0 0.0000 1.34
GTEx Brain Hypothalamus 0 0.0000 1.19
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.30
GTEx Brain Putamen basal ganglia 1 0.1603 1.25
GTEx Breast Mammary Tissue 0 0.0000 1.32
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.22
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.24
GTEx Cells EBV-transformed lymphocytes 1 0.0703 1.37
GTEx Cells Transformed fibroblasts 1 0.0238 1.33
GTEx Colon Sigmoid 0 0.0000 1.23
GTEx Colon Transverse 1 0.0484 1.36
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.27
GTEx Esophagus Mucosa 1 0.0301 1.30
GTEx Esophagus Muscularis 0 0.0000 1.34
GTEx Heart Atrial Appendage 0 0.0000 1.32
GTEx Heart Left Ventricle 0 0.0000 1.31
GTEx Liver 1 0.1395 1.40
GTEx Lung 1 0.0348 1.32
GTEx Muscle Skeletal 1 0.0346 1.35
GTEx Nerve Tibial 0 0.0000 1.30
GTEx Ovary 0 0.0000 1.34
GTEx Pancreas 0 0.0000 1.35
GTEx Pituitary 0 0.0000 1.28
GTEx Prostate 0 0.0000 1.26
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.30
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.35
GTEx Small Intestine Terminal Ileum 0 0.0000 1.42
GTEx Spleen 0 0.0000 1.32
GTEx Stomach 0 0.0000 1.34
GTEx Testis 0 0.0000 1.27
GTEx Thyroid 1 0.0250 1.34
GTEx Uterus 0 0.0000 1.29
GTEx Vagina 0 0.0000 1.39
GTEx Whole Blood 1 0.0502 1.29
METSIM Adipose 1 0.0217 1.28
NTR Blood 0 0.0000 1.26
ROSMAP Brain Pre-frontal Cortex 4 0.0911 1.31
YFS Blood 1 0.0217 1.27
CommonMind Brain Pre-frontal Cortex 5 0.0930 1.36
TCGA Breast Tumor 0 0.0000 1.28
TCGA Breast Normal 1 0.0238 1.21
TCGA Ovarian Tumor 2 0.0684 1.23
TCGA Prostate Tumor 1 0.0289 1.28