Hub : Traits :

Wheeze or whistling in the chest in last year

267 significantly associated models · 59 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 101994731 103686111 3 2 1.8e-12 1.3e-24 6.2e-12 55 IL18R1 IL1R1
2 2 241941773 243048760 7 2 1.4e-12 5.5e-14 7.0e-01 100 AC114730.7 D2HGDH
3 3 48606701 50921261 13 1 2.0e-13 7.2e-13 1.0e+00 100 RBM6
4 5 109716442 111105293 1 1 2.1e-08 1.2e-15 4.7e-14 11 TSLP
5 9 4934896 7345304 2 2 2.6e-11 3.8e-29 1.2e-14 52 GLDC KIAA1432
6 9 138920796 140321666 1 1 2.0e-09 2.4e-09 1.0e+00 100 SNHG7
7 11 75678647 77069746 1 1 9.6e-08 2.0e-12 2.0e-06 54 LRRC32
8 11 110776537 112491227 3 1 1.6e-08 1.0e-08 1.0e+00 100 CRYAB
9 12 66068136 67896003 1 1 2.0e-07 8.4e-06 7.9e-04 43 GRIP1
10 13 99155113 100728229 1 1 1.7e-08 2.5e-07 8.7e-02 89 UBAC2
11 15 66662107 68183665 1 1 5.1e-10 8.8e-15 3.0e-06 64 SMAD3
12 16 10325245 12010444 5 1 3.3e-13 1.8e-18 8.8e-07 69 DEXI
13 16 29972690 31370090 1 1 8.9e-08 2.8e-06 7.7e-01 100 FBRS
14 17 36710513 39048774 15 2 1.9e-14 2.6e-13 6.3e-01 100 ORMDL3 RAPGEFL1
15 20 61576647 62912463 4 1 6.3e-10 7.3e-10 1.0e+00 100 ARFRP1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (in mother) 1.76 1 0 0.0 0.00 1.0e+00 FBRS
Alzheimer’s Disease (including proxy) 1.67 1 0 0.0 0.00 1.0e+00 FBRS
Crohns Disease (2017) 6.57 6 4 12.1 0.03 9.6e-01 ARFRP1 LRRC32 ORMDL3 RAPGEFL1 RBM6 SMAD3
Irritable Bowel Disease (IBD) 8.03 6 6 18.2 -0.06 9.2e-01 ARFRP1 LRRC32 ORMDL3 RAPGEFL1 RBM6 SMAD3
Ulcerative Colitis (UC) 6.01 6 3 9.1 -0.20 7.0e-01 ARFRP1 LRRC32 ORMDL3 RAPGEFL1 RBM6 SMAD3
Verbal and Numeric Reasoning (VNR) 1.97 1 1 3.0 0.00 1.0e+00 RBM6
Prostate Cancer 2.53 1 1 3.0 0.00 1.0e+00 ARFRP1
Age at First Birth 2.59 1 1 3.0 0.00 1.0e+00 RBM6
Coronary Artery Disease (CAD) 2.44 1 0 0.0 0.00 1.0e+00 RBM6
Crohns Disease (2012) 6.28 5 3 9.1 -0.42 4.8e-01 ARFRP1 LRRC32 RAPGEFL1 RBM6 SMAD3
HDL Cholesterol 3.85 2 2 6.1 0.00 1.0e+00 ORMDL3 RAPGEFL1
Lupus 2.22 1 1 3.0 0.00 1.0e+00 ORMDL3
Primary Biliary Cirrhosis 5.10 2 2 6.1 0.00 1.0e+00 ORMDL3 RAPGEFL1
Triglycerides 1.57 1 0 0.0 0.00 1.0e+00 FBRS
Ulcerative Colitis 5.71 3 2 6.1 0.00 1.0e+00 ARFRP1 RAPGEFL1 RBM6
Blood Eosinophil Count 25.07 14 13 39.4 -0.89 2.6e-05 AC114730.7 D2HGDH DEXI FBRS GLDC IL18R1 IL1R1 KIAA1432 LRRC32 ORMDL3 RBM6 SMAD3 TSLP UBAC2
Blood Platelet Count 0.66 2 1 3.0 0.00 1.0e+00 ARFRP1 ORMDL3
Blood Red Count 0.97 4 2 6.1 0.19 8.1e-01 ARFRP1 FBRS ORMDL3 SMAD3
Blood White Count 17.40 7 5 15.2 -0.70 8.0e-02 ARFRP1 DEXI FBRS IL1R1 ORMDL3 RAPGEFL1 RBM6
Heel T-Score 1.25 3 2 6.1 0.00 1.0e+00 FBRS RBM6 SNHG7
BMI 3.32 3 2 6.1 0.00 1.0e+00 ARFRP1 FBRS RBM6
Height 0.63 4 2 6.1 -0.26 7.4e-01 ARFRP1 CRYAB GRIP1 SNHG7
Waist Hip Ratio (WHR) 0.77 1 0 0.0 0.00 1.0e+00 DEXI
Systolic Blood Pressure 1.26 2 2 6.1 0.00 1.0e+00 CRYAB SMAD3
Smoking Status 1.67 1 0 0.0 0.00 1.0e+00 ARFRP1
Allergy or Eczema 27.81 14 12 36.4 -0.93 1.3e-06 AC114730.7 ARFRP1 CRYAB D2HGDH DEXI GLDC IL18R1 IL1R1 KIAA1432 LRRC32 ORMDL3 RAPGEFL1 SMAD3 TSLP
Cardiovascular Disease 2.13 2 2 6.1 0.00 1.0e+00 CRYAB FBRS
Respiratory disease 37.01 16 14 42.4 -0.96 2.3e-09 AC114730.7 ARFRP1 CRYAB D2HGDH DEXI GLDC IL18R1 IL1R1 KIAA1432 LRRC32 ORMDL3 RAPGEFL1 RBM6 SMAD3 TSLP UBAC2
Type 2 Diabetes (T2D) 1.71 1 0 0.0 0.00 1.0e+00 RBM6
Lung FEV1/FVC ratio 3.00 9 3 9.1 0.98 1.7e-06 AC114730.7 D2HGDH DEXI GLDC IL18R1 KIAA1432 ORMDL3 RAPGEFL1 SMAD3
Lung FVC 2.49 4 1 3.0 0.89 1.1e-01 ARFRP1 FBRS ORMDL3 RBM6
Neuroticism 0.85 1 0 0.0 0.00 1.0e+00 RBM6
Hair Pigment 0.15 1 1 3.0 0.00 1.0e+00 KIAA1432
Hand grip strength (left) 1.09 1 0 0.0 0.00 1.0e+00 FBRS
Number of treatments/medications taken 3.77 1 1 3.0 0.00 1.0e+00 RBM6
Medication: Co-codamol 2.83 1 0 0.0 0.00 1.0e+00 RBM6
Impedance of leg (right) 1.55 2 2 6.1 0.00 1.0e+00 FBRS RBM6
Leg fat-free mass (left) 1.70 2 2 6.1 0.00 1.0e+00 FBRS RBM6
Trunk fat percentage 2.67 3 3 9.1 0.00 1.0e+00 ARFRP1 FBRS RBM6
Current tobacco smoking 2.39 1 1 3.0 0.00 1.0e+00 ARFRP1
Fed-up feelings 1.45 1 1 3.0 0.00 1.0e+00 RBM6
Taking other prescription medications 6.79 4 2 6.1 1.00 4.9e-03 D2HGDH ORMDL3 RAPGEFL1 RBM6
Age when periods started (menarche) 1.27 1 0 0.0 0.00 1.0e+00 RBM6
Heel bone mineral density (BMD) T-score, automated (left) 1.08 1 0 0.0 0.00 1.0e+00 RBM6
Qualifications: CSEs or equivalent 1.76 1 0 0.0 0.00 1.0e+00 RBM6
High blood pressure 1.61 2 2 6.1 0.00 1.0e+00 CRYAB FBRS
Hayfever, allergic rhinitis or eczema 24.81 14 11 33.3 0.93 2.1e-06 AC114730.7 ARFRP1 CRYAB D2HGDH DEXI GLDC IL18R1 IL1R1 KIAA1432 LRRC32 ORMDL3 RAPGEFL1 SMAD3 TSLP
Supplements: Glucosamine 1.32 1 0 0.0 0.00 1.0e+00 GLDC
Sitting height 0.60 2 1 3.0 0.00 1.0e+00 CRYAB SNHG7
Body mass index (BMI) 3.77 3 2 6.1 0.00 1.0e+00 ARFRP1 FBRS RBM6
Impedance of leg (left) 1.50 2 2 6.1 0.00 1.0e+00 FBRS RBM6
Leg predicted mass (left) 1.70 2 2 6.1 0.00 1.0e+00 FBRS RBM6
Trunk fat mass 2.86 3 3 9.1 0.00 1.0e+00 ARFRP1 FBRS RBM6
Waist circumference 3.02 3 3 9.1 0.00 1.0e+00 ARFRP1 FBRS RBM6
Number of incorrect matches in round 1.90 1 1 3.0 0.00 1.0e+00 FBRS
Past tobacco smoking 1.20 1 0 0.0 0.00 1.0e+00 GLDC
Frequency of tenseness / restlessness in last 2 weeks 1.78 1 0 0.0 0.00 1.0e+00 RBM6
Forced vital capacity (FVC) 1.63 1 1 3.0 0.00 1.0e+00 ARFRP1
Qualifications: None of the above 1.84 1 1 3.0 0.00 1.0e+00 RBM6
Financial difficulties in last 2 years 1.87 1 0 0.0 0.00 1.0e+00 FBRS
Allergy 34.94 15 14 42.4 -0.96 7.6e-09 AC114730.7 ARFRP1 CRYAB D2HGDH DEXI GLDC IL18R1 IL1R1 KIAA1432 LRRC32 ORMDL3 RAPGEFL1 SMAD3 TSLP UBAC2
Diabetes (self-reported) 1.53 1 0 0.0 0.00 1.0e+00 RBM6
Hayfever/allergic rhinitis (self-reported) 15.51 11 7 21.2 0.97 4.2e-07 AC114730.7 D2HGDH DEXI GLDC IL18R1 KIAA1432 LRRC32 ORMDL3 RAPGEFL1 SMAD3 TSLP
Fluid intelligence score 2.44 1 1 3.0 0.00 1.0e+00 RBM6
Illnesses of siblings 1.62 1 0 0.0 0.00 1.0e+00 FBRS
Neuroticism score 0.96 1 0 0.0 0.00 1.0e+00 RBM6
Weight 2.84 4 2 6.1 1.00 6.3e-04 ARFRP1 FBRS GRIP1 RBM6
Impedance of arm (right) 2.85 6 3 9.1 0.28 5.9e-01 FBRS LRRC32 ORMDL3 RAPGEFL1 RBM6 SMAD3
Arm fat percentage (right) 2.97 3 2 6.1 0.00 1.0e+00 ARFRP1 FBRS RBM6
Trunk fat-free mass 1.28 3 2 6.1 0.00 1.0e+00 FBRS RBM6 SNHG7
Hip circumference 2.86 3 3 9.1 0.00 1.0e+00 ARFRP1 FBRS RBM6
Alcohol intake versus 10 years previously 2.20 1 1 3.0 0.00 1.0e+00 RBM6
Forced expiratory volume in 1-second (FEV1) 1.91 3 1 3.0 0.00 1.0e+00 ARFRP1 FBRS RBM6
Qualifications: A levels/AS levels or equivalent 2.71 1 1 3.0 0.00 1.0e+00 RBM6
Mouth/teeth dental problems: Dentures 2.30 1 1 3.0 0.00 1.0e+00 RBM6
Asthma 36.64 16 13 39.4 0.96 2.1e-09 AC114730.7 ARFRP1 CRYAB D2HGDH DEXI GLDC IL18R1 IL1R1 KIAA1432 LRRC32 ORMDL3 RAPGEFL1 RBM6 SMAD3 TSLP UBAC2
Prospective memory result 1.27 1 0 0.0 0.00 1.0e+00 RBM6
Forced expiratory volume in 1-second (FEV1), Best measure 2.01 3 1 3.0 0.00 1.0e+00 ARFRP1 FBRS RBM6
Impedance of arm (left) 2.71 6 2 6.1 0.26 6.2e-01 FBRS LRRC32 ORMDL3 RAPGEFL1 RBM6 SMAD3
Arm fat mass (right) 3.39 3 2 6.1 0.00 1.0e+00 ARFRP1 FBRS RBM6
Trunk predicted mass 1.27 3 2 6.1 0.00 1.0e+00 FBRS RBM6 SNHG7
Standing height 0.44 1 1 3.0 0.00 1.0e+00 SNHG7
Exposure to tobacco smoke at home 1.19 1 0 0.0 0.00 1.0e+00 RBM6
Tense / 'highly strung' 1.33 1 0 0.0 0.00 1.0e+00 FBRS
Ever highly irritable/argumentative for 2 days 2.25 1 1 3.0 0.00 1.0e+00 RBM6
Qualifications: O levels/GCSEs or equivalent 0.86 1 0 0.0 0.00 1.0e+00 RBM6
Medication for cholesterol, blood pressure or diabetes 2.00 1 0 0.0 0.00 1.0e+00 CRYAB
Medication: Ventolin 100micrograms inhaler 14.61 10 5 15.2 0.99 1.2e-08 AC114730.7 D2HGDH GLDC IL18R1 KIAA1432 LRRC32 ORMDL3 RAPGEFL1 SMAD3 TSLP
Birth weight 1.34 1 1 3.0 0.00 1.0e+00 CRYAB
Chronic bronchitis/emphysema (mother) 2.90 1 0 0.0 0.00 1.0e+00 RBM6
High blood pressure (siblings) 1.27 1 0 0.0 0.00 1.0e+00 FBRS
Forced vital capacity (FVC), Best measure 1.53 3 1 3.0 0.00 1.0e+00 ARFRP1 FBRS RBM6
Body fat percentage 3.07 3 3 9.1 0.00 1.0e+00 ARFRP1 FBRS RBM6
Leg fat percentage (right) 3.50 3 3 9.1 0.00 1.0e+00 ARFRP1 FBRS RBM6
Arm fat-free mass (right) 2.11 2 2 6.1 0.00 1.0e+00 FBRS RBM6
Exposure to tobacco smoke outside home 2.15 1 0 0.0 0.00 1.0e+00 RBM6
Comparative body size at age 10 0.99 1 0 0.0 0.00 1.0e+00 FBRS
Age at first live birth 2.90 1 1 3.0 0.00 1.0e+00 RBM6
Shortness of breath walking on level ground 3.30 1 0 0.0 0.00 1.0e+00 LRRC32
Qualifications: College or University degree 3.68 3 1 3.0 0.00 1.0e+00 ARFRP1 FBRS RBM6
Emphysema/chronic bronchitis 3.28 1 0 0.0 0.00 1.0e+00 RAPGEFL1
Medication: Blood pressure 1.53 1 0 0.0 0.00 1.0e+00 CRYAB
Medication: Seretide 50 evohaler 8.11 4 0 0.0 1.00 3.6e-03 AC114730.7 D2HGDH IL18R1 RBM6
Whole body fat mass 3.35 3 3 9.1 0.00 1.0e+00 ARFRP1 FBRS RBM6
Leg fat mass (right) 3.66 3 3 9.1 0.00 1.0e+00 ARFRP1 FBRS RBM6
Arm predicted mass (right) 2.21 3 2 6.1 0.00 1.0e+00 FBRS GRIP1 RBM6
Pulse rate, automated reading 1.20 2 0 0.0 0.00 1.0e+00 CRYAB RBM6
Alcohol intake frequency. 2.00 2 2 6.1 0.00 1.0e+00 FBRS RBM6
Overall health rating 2.95 2 2 6.1 0.00 1.0e+00 FBRS RBM6
Chest pain or discomfort 3.86 2 0 0.0 0.00 1.0e+00 RAPGEFL1 RBM6
Age at last live birth 2.73 1 1 3.0 0.00 1.0e+00 RBM6
Leg pain on walking 1.97 1 0 0.0 0.00 1.0e+00 RBM6
Qualifications: NVQ or HND or HNC or equivalent 2.04 1 0 0.0 0.00 1.0e+00 RBM6
Knee pain experienced in last month 2.51 2 0 0.0 0.00 1.0e+00 FBRS RBM6
Hypertension (Self-reported) 1.69 2 1 3.0 0.00 1.0e+00 CRYAB FBRS
Illnesses of father: Heart disease 2.20 1 0 0.0 0.00 1.0e+00 SMAD3
Whole body fat-free mass 1.55 2 2 6.1 0.00 1.0e+00 FBRS RBM6
Leg fat-free mass (right) 1.58 2 2 6.1 0.00 1.0e+00 FBRS RBM6
Arm fat percentage (left) 2.96 3 2 6.1 0.00 1.0e+00 ARFRP1 FBRS RBM6
Mood swings 1.55 1 1 3.0 0.00 1.0e+00 RBM6
Diabetes diagnosed by doctor 1.81 1 0 0.0 0.00 1.0e+00 RBM6
Qualifications: nursing, teaching 1.06 1 0 0.0 0.00 1.0e+00 RBM6
Mouth/teeth dental problems: Mouth ulcers 1.86 1 0 0.0 0.00 1.0e+00 RAPGEFL1
Asthma (self-reported) 36.23 16 13 39.4 0.96 3.0e-09 AC114730.7 ARFRP1 CRYAB D2HGDH DEXI GLDC IL18R1 IL1R1 KIAA1432 LRRC32 ORMDL3 RAPGEFL1 RBM6 SMAD3 TSLP UBAC2
Osteoarthritis (self-reported) 1.81 1 0 0.0 0.00 1.0e+00 RBM6
Illnesses of father: None of the above (group 1) 1.96 1 0 0.0 0.00 1.0e+00 SMAD3
Smoking status: Current 2.06 1 0 0.0 0.00 1.0e+00 ARFRP1
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.55 5 2 6.1 -0.96 1.1e-02 ARFRP1 FBRS IL18R1 ORMDL3 RAPGEFL1
Whole body water mass 1.58 2 2 6.1 0.00 1.0e+00 FBRS RBM6
Leg predicted mass (right) 1.56 2 2 6.1 0.00 1.0e+00 FBRS RBM6
Arm fat mass (left) 3.40 3 2 6.1 0.00 1.0e+00 ARFRP1 FBRS RBM6
Number of self-reported non-cancer illnesses 6.38 7 1 3.0 0.99 4.2e-05 ARFRP1 D2HGDH IL1R1 KIAA1432 LRRC32 ORMDL3 RAPGEFL1
Miserableness 2.82 3 1 3.0 0.00 1.0e+00 ORMDL3 RAPGEFL1 RBM6
Financial situation satisfaction 1.90 1 0 0.0 0.00 1.0e+00 RBM6
Medication: Blood pressure 1.92 2 0 0.0 0.00 1.0e+00 CRYAB FBRS
Medication: Bendroflumethiazide 1.44 1 0 0.0 0.00 1.0e+00 CRYAB
Basal metabolic rate 1.86 2 2 6.1 0.00 1.0e+00 FBRS RBM6
Leg fat percentage (left) 3.66 3 3 9.1 0.00 1.0e+00 ARFRP1 FBRS RBM6
Arm fat-free mass (left) 2.21 4 2 6.1 1.00 3.7e-03 ARFRP1 FBRS GRIP1 RBM6
Number of operations (self-reported) 1.69 2 0 0.0 0.00 1.0e+00 DEXI RBM6
Average weekly beer plus cider intake 1.80 1 1 3.0 0.00 1.0e+00 RBM6
Age started oral contraceptive pill 1.48 1 0 0.0 0.00 1.0e+00 RBM6
Diastolic blood pressure, automated reading 1.96 3 0 0.0 0.00 1.0e+00 ARFRP1 FBRS RBM6
Ever depressed for a whole week 2.15 1 0 0.0 0.00 1.0e+00 ORMDL3
Myopia 1.67 1 0 0.0 0.00 1.0e+00 ORMDL3
Vascular/heart problems diagnosed by doctor 1.86 3 1 3.0 0.00 1.0e+00 CRYAB FBRS SMAD3
Cholesterol lowering medication 1.57 1 0 0.0 0.00 1.0e+00 FBRS
Pain experienced in last month 2.13 2 0 0.0 0.00 1.0e+00 FBRS RBM6
Impedance of whole body 2.18 3 2 6.1 0.00 1.0e+00 FBRS LRRC32 RBM6
Leg fat mass (left) 3.72 3 3 9.1 0.00 1.0e+00 ARFRP1 FBRS RBM6
Arm predicted mass (left) 2.24 3 2 6.1 0.00 1.0e+00 FBRS GRIP1 RBM6

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 5 0.1432 1.81
GTEx Adipose Visceral Omentum 4 0.1965 1.85
GTEx Adrenal Gland 3 0.2059 1.74
GTEx Artery Aorta 4 0.1344 1.85
GTEx Artery Coronary 1 0.0845 1.75
GTEx Artery Tibial 8 0.2127 1.87
GTEx Brain Caudate basal ganglia 2 0.2174 1.73
GTEx Brain Cerebellar Hemisphere 5 0.3358 1.94
GTEx Brain Cerebellum 7 0.3532 1.89
GTEx Brain Cortex 3 0.2899 1.85
GTEx Brain Frontal Cortex BA9 4 0.4329 1.99
GTEx Brain Hippocampus 0 0.0000 1.59
GTEx Brain Hypothalamus 1 0.1695 1.77
GTEx Brain Nucleus accumbens basal ganglia 4 0.4624 1.83
GTEx Brain Putamen basal ganglia 3 0.4808 1.88
GTEx Breast Mammary Tissue 8 0.4053 1.93
GTEx Breast Mammary Tissue (Male) 3 0.2515 1.81
GTEx Breast Mammary Tissue (Female) 4 0.2433 1.85
GTEx Cells EBV-transformed lymphocytes 2 0.1405 1.79
GTEx Cells Transformed fibroblasts 12 0.2858 1.90
GTEx Colon Sigmoid 2 0.1368 1.85
GTEx Colon Transverse 8 0.3876 1.90
GTEx Esophagus Gastroesophageal Junction 3 0.2076 1.79
GTEx Esophagus Mucosa 9 0.2711 1.83
GTEx Esophagus Muscularis 6 0.1856 1.89
GTEx Heart Atrial Appendage 4 0.2533 1.81
GTEx Heart Left Ventricle 2 0.1307 1.78
GTEx Liver 2 0.2789 1.61
GTEx Lung 5 0.1740 1.83
GTEx Muscle Skeletal 7 0.2422 1.74
GTEx Nerve Tibial 5 0.1157 1.80
GTEx Ovary 1 0.1101 1.85
GTEx Pancreas 4 0.2451 1.80
GTEx Pituitary 3 0.2691 1.82
GTEx Prostate 2 0.2395 1.88
GTEx Skin Not Sun Exposed Suprapubic 7 0.2847 1.88
GTEx Skin Sun Exposed Lower leg 9 0.2473 1.89
GTEx Small Intestine Terminal Ileum 1 0.2169 1.86
GTEx Spleen 8 0.5670 1.91
GTEx Stomach 3 0.2063 1.82
GTEx Testis 9 0.2853 1.76
GTEx Thyroid 14 0.3501 1.87
GTEx Uterus 2 0.3527 1.87
GTEx Vagina 1 0.1575 1.71
GTEx Whole Blood 7 0.3512 1.84
METSIM Adipose 7 0.1518 1.72
NTR Blood 5 0.2082 1.77
ROSMAP Brain Pre-frontal Cortex 8 0.1822 1.80
YFS Blood 8 0.1732 1.78
CommonMind Brain Pre-frontal Cortex 12 0.2233 1.73
TCGA Breast Tumor 1 0.1304 1.69
TCGA Breast Normal 6 0.1426 1.59
TCGA Ovarian Tumor 3 0.1027 1.63
TCGA Prostate Tumor 10 0.2891 1.69