Hub : Traits :

Loneliness, isolation

30 significantly associated models · 12 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 48702606 50085153 1 1 2.7e-07 3.2e-05 0.290 94 GPX1
2 9 95518076 96910958 1 1 2.0e-08 1.1e-08 0.053 88 FAM120AOS
3 11 46622392 48559571 8 1 9.7e-11 3.2e-11 0.054 92 MTCH2
4 20 46840115 48410403 2 1 1.8e-08 1.1e-06 0.316 96 CSE1L

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 4.45 1 0 0.0 0.00 1.0000 MTCH2
Crohns Disease (2017) 4.43 1 1 3.0 0.00 1.0000 GPX1
Irritable Bowel Disease (IBD) 6.49 1 1 3.0 0.00 1.0000 GPX1
Ulcerative Colitis (UC) 5.77 1 1 3.0 0.00 1.0000 GPX1
Major Depression (MDD) 9.74 2 0 0.0 0.00 1.0000 FAM120AOS GPX1
Reaction Time 2.51 1 0 0.0 0.00 1.0000 CSE1L
Verbal and Numeric Reasoning (VNR) 15.57 4 3 9.1 0.24 0.7606 CSE1L FAM120AOS GPX1 MTCH2
Prostate Cancer 7.93 2 0 0.0 0.00 1.0000 GPX1 MTCH2
Age at First Birth 7.01 1 1 3.0 0.00 1.0000 GPX1
Body Mass Index (BMI) (2010) 6.86 1 1 3.0 0.00 1.0000 MTCH2
Crohns Disease (2012) 2.47 1 0 0.0 0.00 1.0000 GPX1
HDL Cholesterol 3.49 1 0 0.0 0.00 1.0000 MTCH2
Neuroticism 10.30 2 1 3.0 0.00 1.0000 GPX1 MTCH2
Ulcerative Colitis 6.01 1 1 3.0 0.00 1.0000 GPX1
Blood Eosinophil Count 0.95 1 0 0.0 0.00 1.0000 GPX1
Blood Platelet Count 1.96 2 1 3.0 0.00 1.0000 FAM120AOS MTCH2
Blood Red Count 1.35 2 1 3.0 0.00 1.0000 CSE1L MTCH2
Blood White Count 3.73 2 1 3.0 0.00 1.0000 GPX1 MTCH2
Heel T-Score 2.43 1 1 3.0 0.00 1.0000 FAM120AOS
BMI 9.02 2 2 6.1 0.00 1.0000 GPX1 MTCH2
Height 4.52 3 3 9.1 0.00 1.0000 CSE1L GPX1 MTCH2
Waist Hip Ratio (WHR) 1.81 1 1 3.0 0.00 1.0000 GPX1
Systolic Blood Pressure 7.23 3 1 3.0 0.00 1.0000 CSE1L GPX1 MTCH2
Smoking Status 5.12 2 1 3.0 0.00 1.0000 GPX1 MTCH2
Allergy or Eczema 1.61 1 0 0.0 0.00 1.0000 CSE1L
Cardiovascular Disease 1.58 1 0 0.0 0.00 1.0000 GPX1
Hypothyroidism (self reported) 3.75 1 0 0.0 0.00 1.0000 MTCH2
Lung FEV1/FVC ratio 1.75 1 0 0.0 0.00 1.0000 FAM120AOS
Lung FVC 1.87 1 1 3.0 0.00 1.0000 GPX1
Neuroticism 12.03 3 2 6.1 0.00 1.0000 FAM120AOS GPX1 MTCH2
Chronotype (morning person) 3.29 2 0 0.0 0.00 1.0000 FAM120AOS GPX1
Tanning 0.56 1 0 0.0 0.00 1.0000 MTCH2
Hand grip strength (left) 4.64 1 1 3.0 0.00 1.0000 MTCH2
Number of treatments/medications taken 3.64 1 0 0.0 0.00 1.0000 GPX1
Frequency of depressed mood in last 2 weeks 14.27 3 1 3.0 0.00 1.0000 CSE1L FAM120AOS MTCH2
Hearing difficulty/problems: Yes 3.96 1 0 0.0 0.00 1.0000 FAM120AOS
Ever used hormone-replacement therapy (HRT) 4.37 1 0 0.0 0.00 1.0000 MTCH2
Systolic blood pressure, automated reading 4.37 2 1 3.0 0.00 1.0000 GPX1 MTCH2
Eye problems/disorders: Diabetes related eye disease 2.48 1 0 0.0 0.00 1.0000 MTCH2
Medication: Co-codamol 5.43 2 0 0.0 0.00 1.0000 FAM120AOS GPX1
Medication: Metformin 3.86 1 0 0.0 0.00 1.0000 MTCH2
Pack years adult smoking proportion 5.54 1 0 0.0 0.00 1.0000 GPX1
Impedance of leg (right) 2.99 2 2 6.1 0.00 1.0000 GPX1 MTCH2
Leg fat-free mass (left) 1.50 2 0 0.0 0.00 1.0000 CSE1L GPX1
Trunk fat percentage 7.90 2 1 3.0 0.00 1.0000 GPX1 MTCH2
Hand grip strength (right) 4.38 2 0 0.0 0.00 1.0000 CSE1L MTCH2
Townsend deprivation index at recruitment 5.51 1 0 0.0 0.00 1.0000 MTCH2
Current tobacco smoking 5.79 2 0 0.0 0.00 1.0000 GPX1 MTCH2
Maternal smoking around birth 2.90 1 0 0.0 0.00 1.0000 GPX1
Fed-up feelings 11.04 3 1 3.0 0.00 1.0000 FAM120AOS GPX1 MTCH2
Frequency of unenthusiasm / disinterest in last 2 weeks 9.51 4 0 0.0 0.99 0.0057 CSE1L FAM120AOS GPX1 MTCH2
Taking other prescription medications 5.52 1 0 0.0 0.00 1.0000 GPX1
Age when periods started (menarche) 7.29 2 2 6.1 0.00 1.0000 GPX1 MTCH2
Heel bone mineral density (BMD) T-score, automated (left) 1.50 1 0 0.0 0.00 1.0000 FAM120AOS
Qualifications: CSEs or equivalent 2.70 1 0 0.0 0.00 1.0000 GPX1
Medication: Levothyroxine sodium 2.86 1 0 0.0 0.00 1.0000 MTCH2
Sitting height 5.64 2 2 6.1 0.00 1.0000 CSE1L MTCH2
Body mass index (BMI) 10.09 2 2 6.1 0.00 1.0000 GPX1 MTCH2
Impedance of leg (left) 2.82 2 1 3.0 0.00 1.0000 GPX1 MTCH2
Leg predicted mass (left) 1.49 2 0 0.0 0.00 1.0000 CSE1L GPX1
Trunk fat mass 5.54 2 1 3.0 0.00 1.0000 GPX1 MTCH2
Waist circumference 5.03 2 1 3.0 0.00 1.0000 GPX1 MTCH2
Nervous feelings 3.74 1 0 0.0 0.00 1.0000 MTCH2
Frequency of tenseness / restlessness in last 2 weeks 8.59 2 0 0.0 0.00 1.0000 GPX1 MTCH2
Forced vital capacity (FVC) 5.77 3 2 6.1 0.00 1.0000 CSE1L GPX1 MTCH2
Heel bone mineral density (BMD) T-score, automated (right) 1.86 1 0 0.0 0.00 1.0000 FAM120AOS
Ever unenthusiastic/disinterested for a whole week 5.38 1 0 0.0 0.00 1.0000 GPX1
Qualifications: None of the above 10.57 3 1 3.0 0.00 1.0000 CSE1L FAM120AOS GPX1
Financial difficulties in last 2 years 8.96 3 0 0.0 0.00 1.0000 CSE1L FAM120AOS GPX1
Pain all over the body in last month 5.73 1 0 0.0 0.00 1.0000 GPX1
Fluid intelligence score 8.44 3 0 0.0 0.00 1.0000 CSE1L GPX1 MTCH2
Neuroticism score 12.33 3 2 6.1 0.00 1.0000 FAM120AOS GPX1 MTCH2
Weight 3.01 2 1 3.0 0.00 1.0000 GPX1 MTCH2
Impedance of arm (right) 5.15 2 1 3.0 0.00 1.0000 FAM120AOS GPX1
Arm fat percentage (right) 11.11 3 2 6.1 0.00 1.0000 CSE1L GPX1 MTCH2
Trunk fat-free mass 2.35 3 0 0.0 0.00 1.0000 CSE1L GPX1 MTCH2
Hip circumference 4.72 2 2 6.1 0.00 1.0000 GPX1 MTCH2
Alcohol intake versus 10 years previously 4.01 2 0 0.0 0.00 1.0000 GPX1 MTCH2
Father's age at death 4.83 1 0 0.0 0.00 1.0000 GPX1
Worrier / anxious feelings 3.75 1 0 0.0 0.00 1.0000 MTCH2
Frequency of tiredness / lethargy in last 2 weeks 10.50 3 0 0.0 0.00 1.0000 CSE1L GPX1 MTCH2
Forced expiratory volume in 1-second (FEV1) 4.99 3 1 3.0 0.00 1.0000 CSE1L GPX1 MTCH2
Happiness 2.90 1 0 0.0 0.00 1.0000 CSE1L
Noisy workplace 4.57 2 0 0.0 0.00 1.0000 FAM120AOS GPX1
Qualifications: A levels/AS levels or equivalent 11.27 3 1 3.0 0.00 1.0000 CSE1L FAM120AOS GPX1
Mouth/teeth dental problems: Dentures 3.37 1 0 0.0 0.00 1.0000 GPX1
Lung cancer (father) 6.18 2 0 0.0 0.00 1.0000 GPX1 MTCH2
Forced expiratory volume in 1-second (FEV1), Best measure 5.35 3 1 3.0 0.00 1.0000 CSE1L GPX1 MTCH2
Impedance of arm (left) 5.48 2 1 3.0 0.00 1.0000 FAM120AOS GPX1
Arm fat mass (right) 7.55 2 2 6.1 0.00 1.0000 GPX1 MTCH2
Trunk predicted mass 2.27 3 0 0.0 0.00 1.0000 CSE1L GPX1 MTCH2
Standing height 5.01 3 3 9.1 0.00 1.0000 CSE1L GPX1 MTCH2
Exposure to tobacco smoke at home 3.57 1 0 0.0 0.00 1.0000 GPX1
Tense / 'highly strung' 4.87 2 0 0.0 0.00 1.0000 FAM120AOS MTCH2
Seen doctor (GP) for nerves, anxiety, tension or depression 5.88 2 0 0.0 0.00 1.0000 GPX1 MTCH2
Peak expiratory flow (PEF) 1.75 1 0 0.0 0.00 1.0000 MTCH2
Ever highly irritable/argumentative for 2 days 4.61 1 0 0.0 0.00 1.0000 GPX1
Qualifications: O levels/GCSEs or equivalent 9.18 3 1 3.0 0.00 1.0000 CSE1L FAM120AOS GPX1
Medication: Paracetamol 6.75 2 1 3.0 0.00 1.0000 FAM120AOS GPX1
Hypothyroidism/myxoedema (self-reported) 2.60 1 0 0.0 0.00 1.0000 MTCH2
Birth weight 2.67 1 0 0.0 0.00 1.0000 MTCH2
Forced vital capacity (FVC), Best measure 6.61 3 3 9.1 0.00 1.0000 CSE1L GPX1 MTCH2
Body fat percentage 9.10 2 2 6.1 0.00 1.0000 GPX1 MTCH2
Leg fat percentage (right) 10.07 4 2 6.1 0.38 0.6213 CSE1L FAM120AOS GPX1 MTCH2
Arm fat-free mass (right) 2.51 2 0 0.0 0.00 1.0000 CSE1L GPX1
Comparative body size at age 10 8.92 2 2 6.1 0.00 1.0000 FAM120AOS MTCH2
Number of full brothers 5.00 1 0 0.0 0.00 1.0000 GPX1
Wheeze or whistling in the chest in last year 2.90 1 0 0.0 0.00 1.0000 GPX1
Age at first live birth 7.01 1 1 3.0 0.00 1.0000 GPX1
Health satisfaction 4.74 1 0 0.0 0.00 1.0000 GPX1
Qualifications: College or University degree 12.11 3 1 3.0 0.00 1.0000 CSE1L FAM120AOS GPX1
Medication for pain relief, constipation, heartburn 5.04 1 0 0.0 0.00 1.0000 GPX1
Neck or shoulder pain in last month 5.86 1 0 0.0 0.00 1.0000 GPX1
Medication: Seretide 50 evohaler 3.10 1 0 0.0 0.00 1.0000 GPX1
Mean time to correctly identify matches 2.44 1 0 0.0 0.00 1.0000 CSE1L
Whole body fat mass 6.52 2 2 6.1 0.00 1.0000 GPX1 MTCH2
Leg fat mass (right) 7.60 2 2 6.1 0.00 1.0000 GPX1 MTCH2
Arm predicted mass (right) 2.62 2 0 0.0 0.00 1.0000 CSE1L GPX1
Pulse rate, automated reading 1.19 1 0 0.0 0.00 1.0000 GPX1
Alcohol intake frequency. 4.49 1 1 3.0 0.00 1.0000 MTCH2
Comparative height size at age 10 3.74 3 2 6.1 0.00 1.0000 CSE1L GPX1 MTCH2
Suffer from 'nerves' 11.26 1 1 3.0 0.00 1.0000 MTCH2
Overall health rating 9.58 2 2 6.1 0.00 1.0000 FAM120AOS GPX1
Chest pain or discomfort 5.06 2 0 0.0 0.00 1.0000 GPX1 MTCH2
Had major operations 3.90 1 0 0.0 0.00 1.0000 GPX1
Age at last live birth 6.48 1 1 3.0 0.00 1.0000 GPX1
Illness, injury, bereavement, stress in last 2 years 4.10 1 0 0.0 0.00 1.0000 MTCH2
Knee pain experienced in last month 3.78 1 0 0.0 0.00 1.0000 GPX1
Hypertension (Self-reported) 1.76 1 0 0.0 0.00 1.0000 MTCH2
Forced expiratory volume in 1-second (FEV1), predicted 2.73 1 0 0.0 0.00 1.0000 MTCH2
Whole body fat-free mass 1.72 2 0 0.0 0.00 1.0000 CSE1L GPX1
Leg fat-free mass (right) 1.52 2 0 0.0 0.00 1.0000 CSE1L GPX1
Arm fat percentage (left) 11.49 2 2 6.1 0.00 1.0000 GPX1 MTCH2
Mood swings 14.64 3 2 6.1 0.00 1.0000 FAM120AOS GPX1 MTCH2
Long-standing illness, disability or infirmity 3.14 1 0 0.0 0.00 1.0000 FAM120AOS
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.35 1 0 0.0 0.00 1.0000 GPX1
Smoking status: Current 6.16 2 0 0.0 0.00 1.0000 GPX1 MTCH2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.70 1 0 0.0 0.00 1.0000 GPX1
Whole body water mass 1.74 2 0 0.0 0.00 1.0000 CSE1L GPX1
Leg predicted mass (right) 1.50 2 0 0.0 0.00 1.0000 CSE1L GPX1
Arm fat mass (left) 7.59 2 2 6.1 0.00 1.0000 GPX1 MTCH2
Number of self-reported non-cancer illnesses 2.92 1 0 0.0 0.00 1.0000 GPX1
Miserableness 18.10 3 2 6.1 0.00 1.0000 CSE1L GPX1 MTCH2
Guilty feelings 7.49 3 0 0.0 0.00 1.0000 FAM120AOS GPX1 MTCH2
Financial situation satisfaction 9.87 1 1 3.0 0.00 1.0000 GPX1
Pain type(s) experienced in last month: Hip pain 2.80 1 0 0.0 0.00 1.0000 FAM120AOS
Medication: Paracetamol 5.98 1 1 3.0 0.00 1.0000 GPX1
Illnesses of father: High blood pressure 2.87 1 0 0.0 0.00 1.0000 MTCH2
Alcohol drinker status: Never 3.78 1 0 0.0 0.00 1.0000 MTCH2
Basal metabolic rate 1.71 2 0 0.0 0.00 1.0000 CSE1L GPX1
Leg fat percentage (left) 10.70 4 2 6.1 0.36 0.6353 CSE1L FAM120AOS GPX1 MTCH2
Arm fat-free mass (left) 2.55 2 1 3.0 0.00 1.0000 CSE1L GPX1
Number of operations (self-reported) 6.24 2 0 0.0 0.00 1.0000 FAM120AOS GPX1
Average weekly beer plus cider intake 5.68 2 0 0.0 0.00 1.0000 GPX1 MTCH2
Irritability 5.90 1 0 0.0 0.00 1.0000 GPX1
Risk taking 2.54 1 0 0.0 0.00 1.0000 FAM120AOS
Age started oral contraceptive pill 3.72 1 0 0.0 0.00 1.0000 GPX1
Diastolic blood pressure, automated reading 3.49 2 0 0.0 0.00 1.0000 GPX1 MTCH2
Ever depressed for a whole week 7.48 2 0 0.0 0.00 1.0000 CSE1L GPX1
Unable to work because of sickness or disability 4.09 1 0 0.0 0.00 1.0000 FAM120AOS
Myopia 3.57 1 0 0.0 0.00 1.0000 MTCH2
Vascular/heart problems diagnosed by doctor 2.07 1 0 0.0 0.00 1.0000 GPX1
Pain experienced in last month 6.49 2 1 3.0 0.00 1.0000 FAM120AOS GPX1
Pack years of smoking 4.35 1 0 0.0 0.00 1.0000 GPX1
Impedance of whole body 3.59 1 1 3.0 0.00 1.0000 GPX1
Leg fat mass (left) 8.08 2 2 6.1 0.00 1.0000 GPX1 MTCH2
Arm predicted mass (left) 2.54 2 1 3.0 0.00 1.0000 CSE1L GPX1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.40
GTEx Adipose Visceral Omentum 0 0.0000 1.39
GTEx Adrenal Gland 0 0.0000 1.32
GTEx Artery Aorta 0 0.0000 1.33
GTEx Artery Coronary 0 0.0000 1.47
GTEx Artery Tibial 1 0.0266 1.38
GTEx Brain Caudate basal ganglia 0 0.0000 1.34
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.44
GTEx Brain Cerebellum 0 0.0000 1.43
GTEx Brain Cortex 2 0.1932 1.49
GTEx Brain Frontal Cortex BA9 1 0.1082 1.44
GTEx Brain Hippocampus 0 0.0000 1.40
GTEx Brain Hypothalamus 0 0.0000 1.38
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.26
GTEx Brain Putamen basal ganglia 0 0.0000 1.41
GTEx Breast Mammary Tissue 1 0.0507 1.37
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.33
GTEx Breast Mammary Tissue (Female) 1 0.0608 1.35
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.48
GTEx Cells Transformed fibroblasts 2 0.0476 1.43
GTEx Colon Sigmoid 0 0.0000 1.37
GTEx Colon Transverse 2 0.0969 1.44
GTEx Esophagus Gastroesophageal Junction 1 0.0692 1.46
GTEx Esophagus Mucosa 0 0.0000 1.40
GTEx Esophagus Muscularis 1 0.0309 1.42
GTEx Heart Atrial Appendage 2 0.1267 1.42
GTEx Heart Left Ventricle 0 0.0000 1.39
GTEx Liver 0 0.0000 1.48
GTEx Lung 1 0.0348 1.41
GTEx Muscle Skeletal 1 0.0346 1.40
GTEx Nerve Tibial 0 0.0000 1.41
GTEx Ovary 0 0.0000 1.34
GTEx Pancreas 0 0.0000 1.34
GTEx Pituitary 1 0.0897 1.47
GTEx Prostate 0 0.0000 1.42
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.49
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.46
GTEx Small Intestine Terminal Ileum 0 0.0000 1.55
GTEx Spleen 1 0.0709 1.46
GTEx Stomach 0 0.0000 1.44
GTEx Testis 1 0.0317 1.41
GTEx Thyroid 0 0.0000 1.34
GTEx Uterus 0 0.0000 1.47
GTEx Vagina 0 0.0000 1.39
GTEx Whole Blood 1 0.0502 1.43
METSIM Adipose 2 0.0434 1.34
NTR Blood 1 0.0416 1.36
ROSMAP Brain Pre-frontal Cortex 1 0.0228 1.41
YFS Blood 2 0.0433 1.33
CommonMind Brain Pre-frontal Cortex 2 0.0372 1.37
TCGA Breast Tumor 0 0.0000 1.39
TCGA Breast Normal 0 0.0000 1.30
TCGA Ovarian Tumor 0 0.0000 1.33
TCGA Prostate Tumor 0 0.0000 1.35