Hub : Traits :

Alcohol usually taken with meals

61 significantly associated models · 20 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 43073464 44618031 3 1 9.4e-09 8.9e-08 0.0063 74 HYI
2 1 150415631 151793174 1 1 1.5e-07 1.1e-06 0.4730 98 SEMA6C
3 1 172881827 175663031 6 1 7.3e-11 1.2e-10 1.0000 100 ANKRD45
4 1 235988566 237463399 4 1 1.2e-09 3.5e-10 0.0885 93 RP11-385F5.4
5 7 116660803 118207833 1 1 4.5e-08 1.3e-07 0.1750 93 CTTNBP2
6 11 56666189 58284951 3 2 2.3e-08 1.1e-07 1.0000 100 CTNND1 ZDHHC5
7 17 1588930 3000009 2 1 1.1e-09 8.1e-09 0.0765 91 RP1-59D14.1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Major Depression (MDD) 4.68 2 1 3.0 0.00 1.0000 CTTNBP2 ZDHHC5
Verbal and Numeric Reasoning (VNR) 2.33 2 0 0.0 0.00 1.0000 HYI ZDHHC5
Neuroticism 3.93 1 0 0.0 0.00 1.0000 RP1-59D14.1
Schizophrenia 2.74 2 0 0.0 0.00 1.0000 ANKRD45 ZDHHC5
Blood Eosinophil Count 1.07 3 0 0.0 0.00 1.0000 CTNND1 SEMA6C ZDHHC5
Blood Platelet Count 2.32 3 3 9.1 0.00 1.0000 RP11-385F5.4 RP1-59D14.1 ZDHHC5
Blood Red Count 0.94 3 0 0.0 0.00 1.0000 ANKRD45 RP1-59D14.1 ZDHHC5
Blood White Count 0.87 1 0 0.0 0.00 1.0000 ANKRD45
Heel T-Score 1.31 3 2 6.1 0.00 1.0000 ANKRD45 RP1-59D14.1 ZDHHC5
BMI 1.29 1 1 3.0 0.00 1.0000 SEMA6C
Height 0.60 4 1 3.0 -0.99 0.0057 ANKRD45 CTTNBP2 HYI ZDHHC5
Waist Hip Ratio (WHR) 0.75 1 0 0.0 0.00 1.0000 CTTNBP2
Systolic Blood Pressure 2.78 3 2 6.1 0.00 1.0000 CTNND1 HYI ZDHHC5
Smoking Status 4.30 2 1 3.0 0.00 1.0000 ANKRD45 CTTNBP2
Type 2 Diabetes (T2D) 1.42 1 0 0.0 0.00 1.0000 CTTNBP2
Lung FEV1/FVC ratio 1.65 2 1 3.0 0.00 1.0000 CTTNBP2 ZDHHC5
Lung FVC 0.87 1 0 0.0 0.00 1.0000 CTTNBP2
Neuroticism 5.89 5 1 3.0 0.99 0.0014 ANKRD45 CTNND1 CTTNBP2 RP1-59D14.1 ZDHHC5
Chronotype (morning person) 2.48 2 0 0.0 0.00 1.0000 CTNND1 ZDHHC5
Tanning 0.26 1 0 0.0 0.00 1.0000 HYI
Hand grip strength (left) 1.05 1 0 0.0 0.00 1.0000 ZDHHC5
Sensitivity / hurt feelings 3.28 1 0 0.0 0.00 1.0000 ZDHHC5
Frequency of depressed mood in last 2 weeks 4.28 1 0 0.0 0.00 1.0000 ZDHHC5
Relative age of first facial hair 2.47 1 0 0.0 0.00 1.0000 SEMA6C
Systolic blood pressure, automated reading 2.25 2 0 0.0 0.00 1.0000 RP11-385F5.4 ZDHHC5
Medication: Metformin 2.14 1 0 0.0 0.00 1.0000 CTTNBP2
Pack years adult smoking proportion 4.22 1 0 0.0 0.00 1.0000 RP1-59D14.1
Impedance of leg (right) 1.14 2 1 3.0 0.00 1.0000 RP1-59D14.1 SEMA6C
Leg fat-free mass (left) 0.71 1 0 0.0 0.00 1.0000 SEMA6C
Trunk fat percentage 1.69 3 0 0.0 0.00 1.0000 RP1-59D14.1 SEMA6C ZDHHC5
Hand grip strength (right) 0.85 1 0 0.0 0.00 1.0000 ZDHHC5
Townsend deprivation index at recruitment 4.29 2 0 0.0 0.00 1.0000 CTTNBP2 ZDHHC5
Current tobacco smoking 3.67 1 0 0.0 0.00 1.0000 CTTNBP2
Fed-up feelings 5.54 2 1 3.0 0.00 1.0000 CTTNBP2 ZDHHC5
Frequency of unenthusiasm / disinterest in last 2 weeks 5.75 2 0 0.0 0.00 1.0000 CTTNBP2 ZDHHC5
Age when periods started (menarche) 2.93 3 0 0.0 0.00 1.0000 ANKRD45 HYI SEMA6C
Qualifications: CSEs or equivalent 2.53 1 0 0.0 0.00 1.0000 HYI
Sitting height 1.36 2 1 3.0 0.00 1.0000 HYI ZDHHC5
High blood pressure (mother) 2.44 1 0 0.0 0.00 1.0000 HYI
Body mass index (BMI) 1.21 1 1 3.0 0.00 1.0000 SEMA6C
Impedance of leg (left) 1.27 2 1 3.0 0.00 1.0000 RP1-59D14.1 SEMA6C
Leg predicted mass (left) 0.71 1 0 0.0 0.00 1.0000 SEMA6C
Trunk fat mass 1.18 1 0 0.0 0.00 1.0000 SEMA6C
Waist circumference 0.95 1 0 0.0 0.00 1.0000 SEMA6C
Past tobacco smoking 2.13 1 0 0.0 0.00 1.0000 CTTNBP2
Qualifications: None of the above 5.46 2 1 3.0 0.00 1.0000 HYI ZDHHC5
Financial difficulties in last 2 years 4.00 2 0 0.0 0.00 1.0000 CTTNBP2 ZDHHC5
Diabetes (self-reported) 2.43 1 0 0.0 0.00 1.0000 CTTNBP2
Fluid intelligence score 2.92 2 1 3.0 0.00 1.0000 HYI ZDHHC5
Neuroticism score 6.02 3 1 3.0 0.00 1.0000 CTTNBP2 RP1-59D14.1 ZDHHC5
Weight 0.72 1 0 0.0 0.00 1.0000 SEMA6C
Impedance of arm (right) 1.09 2 0 0.0 0.00 1.0000 SEMA6C ZDHHC5
Arm fat percentage (right) 1.72 2 0 0.0 0.00 1.0000 SEMA6C ZDHHC5
Trunk fat-free mass 1.14 2 0 0.0 0.00 1.0000 SEMA6C ZDHHC5
Hip circumference 0.85 1 0 0.0 0.00 1.0000 SEMA6C
Worrier / anxious feelings 2.99 1 1 3.0 0.00 1.0000 ZDHHC5
Frequency of tiredness / lethargy in last 2 weeks 7.33 4 2 6.1 -0.99 0.0091 ANKRD45 CTNND1 RP1-59D14.1 ZDHHC5
Forced expiratory volume in 1-second (FEV1) 1.86 2 0 0.0 0.00 1.0000 CTTNBP2 ZDHHC5
Qualifications: A levels/AS levels or equivalent 4.49 2 1 3.0 0.00 1.0000 CTTNBP2 HYI
Mouth/teeth dental problems: Dentures 1.80 1 0 0.0 0.00 1.0000 HYI
Forced expiratory volume in 1-second (FEV1), Best measure 1.58 1 0 0.0 0.00 1.0000 ZDHHC5
Impedance of arm (left) 1.16 2 0 0.0 0.00 1.0000 SEMA6C ZDHHC5
Arm fat mass (right) 1.26 1 1 3.0 0.00 1.0000 SEMA6C
Trunk predicted mass 1.12 2 0 0.0 0.00 1.0000 SEMA6C ZDHHC5
Standing height 0.66 2 0 0.0 0.00 1.0000 HYI ZDHHC5
Tense / 'highly strung' 2.46 1 0 0.0 0.00 1.0000 ZDHHC5
Seen doctor (GP) for nerves, anxiety, tension or depression 3.71 2 0 0.0 0.00 1.0000 CTTNBP2 ZDHHC5
Peak expiratory flow (PEF) 2.42 2 0 0.0 0.00 1.0000 CTTNBP2 ZDHHC5
Qualifications: O levels/GCSEs or equivalent 2.39 1 0 0.0 0.00 1.0000 HYI
Headache pain in last month 2.35 2 0 0.0 0.00 1.0000 ANKRD45 ZDHHC5
Body fat percentage 1.85 3 0 0.0 0.00 1.0000 RP1-59D14.1 SEMA6C ZDHHC5
Leg fat percentage (right) 1.97 2 0 0.0 0.00 1.0000 RP1-59D14.1 SEMA6C
Arm fat-free mass (right) 1.00 2 0 0.0 0.00 1.0000 SEMA6C ZDHHC5
Exposure to tobacco smoke outside home 3.73 1 1 3.0 0.00 1.0000 CTTNBP2
Worry too long after embarrassment 7.18 3 2 6.1 0.00 1.0000 CTTNBP2 RP1-59D14.1 ZDHHC5
Seen a psychiatrist for nerves, anxiety, tension or depression 2.12 1 0 0.0 0.00 1.0000 CTTNBP2
Wheeze or whistling in the chest in last year 2.00 1 0 0.0 0.00 1.0000 ANKRD45
Qualifications: College or University degree 5.26 4 1 3.0 0.98 0.0196 CTTNBP2 HYI RP1-59D14.1 ZDHHC5
Whole body fat mass 1.23 1 0 0.0 0.00 1.0000 SEMA6C
Leg fat mass (right) 1.44 2 1 3.0 0.00 1.0000 RP1-59D14.1 SEMA6C
Arm predicted mass (right) 0.94 1 0 0.0 0.00 1.0000 SEMA6C
Pulse rate, automated reading 3.45 4 2 6.1 -0.60 0.3988 ANKRD45 HYI RP1-59D14.1 ZDHHC5
Alcohol intake frequency. 3.92 3 0 0.0 0.00 1.0000 CTNND1 HYI ZDHHC5
Comparative height size at age 10 1.07 1 0 0.0 0.00 1.0000 HYI
Overall health rating 4.73 2 1 3.0 0.00 1.0000 RP1-59D14.1 ZDHHC5
Illness, injury, bereavement, stress in last 2 years 2.53 1 0 0.0 0.00 1.0000 CTTNBP2
Whole body fat-free mass 0.94 1 0 0.0 0.00 1.0000 SEMA6C
Leg fat-free mass (right) 0.65 1 0 0.0 0.00 1.0000 SEMA6C
Arm fat percentage (left) 1.73 2 0 0.0 0.00 1.0000 SEMA6C ZDHHC5
Average weekly red wine intake 10.89 4 2 6.1 0.96 0.0380 CTNND1 RP11-385F5.4 RP1-59D14.1 ZDHHC5
Mood swings 3.01 1 0 0.0 0.00 1.0000 CTTNBP2
Loneliness, isolation 3.77 1 0 0.0 0.00 1.0000 ZDHHC5
Qualifications: nursing, teaching 3.72 2 0 0.0 0.00 1.0000 HYI ZDHHC5
Smoking status: Current 3.36 1 0 0.0 0.00 1.0000 CTTNBP2
Whole body water mass 0.94 1 0 0.0 0.00 1.0000 SEMA6C
Leg predicted mass (right) 0.67 1 0 0.0 0.00 1.0000 SEMA6C
Arm fat mass (left) 1.33 1 1 3.0 0.00 1.0000 SEMA6C
Average weekly champagne plus white wine intake 2.61 1 0 0.0 0.00 1.0000 HYI
Miserableness 3.55 1 0 0.0 0.00 1.0000 CTTNBP2
Guilty feelings 4.62 2 1 3.0 0.00 1.0000 CTTNBP2 ZDHHC5
Mother's age at death 2.39 1 0 0.0 0.00 1.0000 CTNND1
Ever smoked 3.36 1 1 3.0 0.00 1.0000 CTTNBP2
Basal metabolic rate 0.82 1 0 0.0 0.00 1.0000 SEMA6C
Leg fat percentage (left) 1.99 2 0 0.0 0.00 1.0000 RP1-59D14.1 SEMA6C
Arm fat-free mass (left) 1.05 1 1 3.0 0.00 1.0000 SEMA6C
Average weekly beer plus cider intake 3.97 1 0 0.0 0.00 1.0000 CTTNBP2
Fractured/broken bones in last 5 years 2.23 1 0 0.0 0.00 1.0000 CTTNBP2
Unable to work because of sickness or disability 3.34 1 0 0.0 0.00 1.0000 ZDHHC5
Commuting to job workplace: Cycle 4.04 1 0 0.0 0.00 1.0000 RP1-59D14.1
Pack years of smoking 4.17 1 0 0.0 0.00 1.0000 RP1-59D14.1
Impedance of whole body 1.13 2 0 0.0 0.00 1.0000 RP1-59D14.1 SEMA6C
Leg fat mass (left) 1.43 2 1 3.0 0.00 1.0000 RP1-59D14.1 SEMA6C
Arm predicted mass (left) 1.02 1 0 0.0 0.00 1.0000 SEMA6C

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.0573 1.62
GTEx Adipose Visceral Omentum 2 0.0982 1.67
GTEx Adrenal Gland 1 0.0686 1.65
GTEx Artery Aorta 0 0.0000 1.63
GTEx Artery Coronary 0 0.0000 1.55
GTEx Artery Tibial 1 0.0266 1.67
GTEx Brain Caudate basal ganglia 2 0.2174 1.71
GTEx Brain Cerebellar Hemisphere 1 0.0672 1.69
GTEx Brain Cerebellum 0 0.0000 1.63
GTEx Brain Cortex 0 0.0000 1.60
GTEx Brain Frontal Cortex BA9 0 0.0000 1.63
GTEx Brain Hippocampus 0 0.0000 1.40
GTEx Brain Hypothalamus 0 0.0000 1.63
GTEx Brain Nucleus accumbens basal ganglia 1 0.1156 1.57
GTEx Brain Putamen basal ganglia 0 0.0000 1.70
GTEx Breast Mammary Tissue 2 0.1013 1.66
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.55
GTEx Breast Mammary Tissue (Female) 1 0.0608 1.62
GTEx Cells EBV-transformed lymphocytes 2 0.1405 1.61
GTEx Cells Transformed fibroblasts 4 0.0953 1.64
GTEx Colon Sigmoid 0 0.0000 1.65
GTEx Colon Transverse 2 0.0969 1.63
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.64
GTEx Esophagus Mucosa 1 0.0301 1.67
GTEx Esophagus Muscularis 1 0.0309 1.71
GTEx Heart Atrial Appendage 0 0.0000 1.67
GTEx Heart Left Ventricle 3 0.1961 1.72
GTEx Liver 0 0.0000 1.52
GTEx Lung 5 0.1740 1.66
GTEx Muscle Skeletal 0 0.0000 1.66
GTEx Nerve Tibial 1 0.0231 1.60
GTEx Ovary 0 0.0000 1.60
GTEx Pancreas 1 0.0613 1.68
GTEx Pituitary 0 0.0000 1.47
GTEx Prostate 0 0.0000 1.46
GTEx Skin Not Sun Exposed Suprapubic 3 0.1220 1.74
GTEx Skin Sun Exposed Lower leg 4 0.1099 1.63
GTEx Small Intestine Terminal Ileum 0 0.0000 1.65
GTEx Spleen 0 0.0000 1.64
GTEx Stomach 2 0.1376 1.70
GTEx Testis 2 0.0634 1.64
GTEx Thyroid 2 0.0500 1.66
GTEx Uterus 0 0.0000 1.55
GTEx Vagina 0 0.0000 1.86
GTEx Whole Blood 0 0.0000 1.64
METSIM Adipose 2 0.0434 1.54
NTR Blood 2 0.0833 1.62
ROSMAP Brain Pre-frontal Cortex 2 0.0455 1.72
YFS Blood 2 0.0433 1.58
CommonMind Brain Pre-frontal Cortex 4 0.0744 1.66
TCGA Breast Tumor 0 0.0000 1.72
TCGA Breast Normal 1 0.0238 1.46
TCGA Ovarian Tumor 1 0.0342 1.66
TCGA Prostate Tumor 1 0.0289 1.56