Hub : Genes

SLC30A9

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1700 0.0370 0.0e+00 0.173 0.170 0.161 0.177 0.166 1.3e-20 3.7e-20 3.8e-19 4.5e-21 9.2e-20
2 METSIM Adipose 0.1135 0.0373 4.1e-04 0.010 0.007 0.030 0.020 0.008 1.1e-02 2.8e-02 2.1e-05 4.6e-04 2.0e-02
3 ROSMAP Brain Pre-frontal Cortex 0.0993 0.0299 3.0e-08 0.042 0.063 0.051 0.065 0.044 3.7e-06 1.5e-08 3.6e-07 1.0e-08 2.0e-06
4 YFS Blood 0.0567 0.0206 3.5e-04 0.002 0.006 0.010 0.011 0.001 8.3e-02 3.4e-03 2.7e-04 1.5e-04 9.9e-02
5 TCGA Brain Lower Grade Glioma 0.0508 0.0304 1.5e-05 0.026 0.036 0.037 NA 0.037 5.7e-04 5.8e-05 3.9e-05 NA 4.7e-05
6 TCGA Uterine Corpus Endometrial Carcinoma 0.2950 0.1230 1.4e-03 0.051 0.038 0.073 NA 0.088 1.5e-02 3.3e-02 4.4e-03 NA 1.9e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.3 0.6 1.3 -0.7 0.2 -0.8 0.2 -1.2 -0.9
Bipolar Disorder or Schizophrenia 0.9 2.2 6.8 -1.9 0.2 -1.1 -0.4 -2.6 -1.1
Depressed Affect (Nagel 2018) 2.5 5.2 13.3 -2.3 -0.7 -2.8 -1.4 -3.6 -1.4
Depression (Nagel 2018) 4.7 7.0 13.3 -3.2 0.1 -3.7 -1.2 -3.4 -2.4
Intelligence (Savage-Jansen 2018) 0.6 1.8 5.1 -1.0 -0.3 -2.3 -1.1 -1.3 -1.4
Neuroticism (Nagel 2018) 5.2 12.1 27.9 -4.2 -0.2 -4.4 -1.2 -5.3 -2.5
Schizophrenia (2018) 0.9 1.9 5.9 -2.0 0.1 -0.8 -0.8 -2.4 -0.7
Schizophrenia vs Biploar Disorder 0.8 1.1 2.8 -0.5 -1.5 -0.8 -1.7 -0.9 -0.2
Worry (Nagel 2018) 3.7 7.8 17.4 -3.5 0.1 -3.3 0.2 -4.2 -2.6
Alzheimer’s Disease (in mother) 0.4 0.5 1.5 -0.3 0.3 -0.9 -0.1 -0.6 -1.2
Alzheimer’s Disease (in father) 1.0 1.1 4.1 -1.1 0.3 -0.0 -0.8 -0.8 -2.0
Alzheimer’s Disease (including proxy) 1.0 1.5 4.9 -1.0 0.6 -0.5 -0.9 -1.3 -2.2
Crohns Disease (2017) 0.3 0.6 1.6 0.9 -0.9 0.6 -0.2 1.3 0.3
Irritable Bowel Disease (IBD) 0.2 0.4 0.9 0.5 -0.9 0.5 0.0 0.9 0.0
Ulcerative Colitis (UC) 0.0 0.1 0.3 0.1 -0.5 0.2 0.3 0.4 -0.1
Major Depression (MDD) 9.7 11.8 22.7 -4.8 -0.5 -3.7 -2.6 -4.4 -2.9
Reaction Time 1.3 2.5 5.8 -1.7 0.5 -1.3 2.1 -2.4 -0.7
Verbal and Numeric Reasoning (VNR) 0.8 1.9 5.1 -0.7 -1.0 -1.6 -2.3 -0.8 -1.2
Breast Cancer 1.4 3.4 7.1 2.7 0.4 1.9 0.5 2.3 2.0
Ovarian Cancer 0.9 1.2 3.8 -0.6 1.9 -0.4 0.8 -1.0 -1.0
Prostate Cancer 0.7 0.9 1.9 -0.8 0.9 -0.9 1.4 -1.2 -0.4
Age at First Birth 1.2 1.7 3.3 -1.6 -0.6 -1.8 -0.8 -1.3 -1.3
Bipolar Disorder (2011) 0.5 0.5 1.2 -1.1 -0.6 -0.4 0.4 -1.0 -0.1
Body Mass Index (BMI) (2010) 1.3 1.8 3.0 1.3 1.7 1.2 -0.3 1.7 1.1
Coronary Artery Disease (CAD) 1.5 1.8 4.1 1.6 -0.8 0.8 0.6 2.0 1.5
Crohns Disease (2012) 1.0 1.6 3.9 1.3 -1.3 0.6 -1.4 2.0 0.6
Mean Putamen Volume 0.2 0.2 0.7 -0.5 -0.3 0.8 0.5 0.0 -0.0
Fasting Glucose 2.5 3.0 5.4 1.6 -1.6 2.0 -0.3 1.7 2.3
HbA1C 1.2 1.3 2.8 -0.9 -0.6 -0.8 -1.6 -0.7 -1.7
HDL Cholesterol 0.4 0.7 1.9 1.2 -0.4 0.5 1.4 0.9 -0.3
LDL Cholesterol 0.6 0.9 2.2 -0.9 0.7 -0.8 1.5 -0.8 -0.7
Lupus 1.1 1.6 3.9 -1.5 0.8 -1.6 -0.4 -2.0 -0.4
Neuroticism (2016) 0.7 1.0 2.3 -0.7 -0.2 -1.1 -1.5 -0.8 -1.1
Primary Biliary Cirrhosis 1.1 1.6 4.9 1.1 -2.2 1.1 -0.4 0.6 1.2
Rheumatoid Arthritis 0.5 0.7 0.9 0.9 -0.9 0.7 -1.0 0.9 0.2
Schizophrenia (2014) 0.6 1.4 5.3 -1.5 0.3 -0.7 -0.1 -2.3 -0.4
Triglycerides 0.5 0.8 2.3 0.6 0.4 1.1 -0.8 0.2 1.5
Type 2 Diabetes (T2D) (2012) 1.5 1.8 2.6 1.6 0.8 1.6 -0.3 1.4 1.6
Ulcerative Colitis 1.1 1.6 3.1 1.0 -1.2 1.5 0.2 1.3 1.8
Blood Eosinophil Count 0.2 1.2 2.2 1.2 -1.0 1.5 -0.8 1.4 0.1
Blood Platelet Count 0.2 2.4 5.8 0.5 -1.4 2.4 -0.6 0.6 2.4
Blood Red Count 0.2 1.5 2.7 -1.0 -1.6 -0.4 -1.2 -1.3 -1.4
Blood White Count 0.2 1.4 4.8 -1.2 1.3 -0.8 -2.2 -0.5 -0.3
Heel T-Score 0.2 1.3 3.7 -1.7 1.9 -1.1 -0.0 -0.5 0.1
BMI 0.3 1.8 5.9 1.3 0.7 1.3 -0.8 0.7 2.4
Height 0.8 16.3 30.5 5.5 0.7 5.0 3.3 5.1 2.4
Waist Hip Ratio (WHR) 1.1 4.8 9.0 -3.0 0.1 -2.4 -0.4 -2.8 -2.4
Systolic Blood Pressure 1.3 6.3 13.4 2.5 -1.6 3.7 1.6 1.8 3.2
Smoking Status 0.2 0.5 1.0 1.0 0.3 -0.5 -0.9 0.3 0.9
Allergy or Eczema 4.7 12.4 25.1 -4.0 1.2 -4.5 -2.4 -5.0 -2.4
Cardiovascular Disease 1.6 5.4 9.1 3.0 -0.9 3.0 2.0 2.2 2.3
Hypothyroidism (self reported) 0.7 1.5 3.3 -1.5 -0.0 -0.6 -1.6 -1.0 -1.8
Respiratory disease 0.6 1.4 2.6 -1.4 0.6 -1.3 -0.1 -1.6 -1.3
Type 2 Diabetes (T2D) (2018) 2.1 3.9 8.1 2.0 0.8 2.9 2.1 1.1 2.2
Lung FEV1/FVC ratio 0.5 2.5 7.4 -1.8 -0.5 -1.6 -1.2 -2.7 -0.7
Lung FVC 0.3 1.6 5.7 -0.4 0.1 -0.5 -2.4 -1.8 -0.9
Neuroticism 4.6 11.0 23.8 -4.1 -0.5 -4.3 -1.1 -4.9 -2.2
Chronotype (morning person) 0.8 1.9 7.7 0.9 2.8 -0.7 1.2 0.8 0.5
Hair Pigment 0.1 1.6 3.7 1.7 0.7 1.2 0.3 0.9 1.9
Tanning 0.0 0.5 1.3 1.1 0.5 0.1 0.4 1.0 0.7
Hand grip strength (left) 0.1 0.2 0.4 -0.0 0.7 0.5 0.6 0.0 -0.0
Number of treatments/medications taken 1.3 2.4 4.2 -2.1 1.1 -1.6 0.9 -1.9 -1.3
Average weekly spirits intake 0.5 0.6 1.6 1.0 0.4 0.8 1.3 0.5 0.3
Sensitivity / hurt feelings 1.0 1.7 3.6 -1.7 -0.5 -1.0 -1.4 -1.9 -0.8
Frequency of depressed mood in last 2 weeks 5.8 8.1 15.6 -3.5 -0.2 -3.5 -1.0 -4.0 -2.6
Hearing difficulty/problems: Yes 0.7 1.1 3.8 -1.5 0.6 -0.1 -0.1 -2.0 -0.3
Relative age of first facial hair 0.1 0.2 0.5 0.4 0.3 -0.0 0.1 0.7 0.5
Other serious medical condition/disability diagnosed by doctor 4.0 5.1 16.6 -2.3 0.8 -4.1 -0.7 -2.2 -1.7
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.4 -0.3 0.5 0.5 0.4 0.6 -0.2
Ever had hysterectomy (womb removed) 0.3 0.3 0.6 -0.7 -0.5 0.7 0.7 0.2 0.2
Systolic blood pressure, automated reading 0.9 2.7 7.5 1.2 -1.1 2.7 1.4 0.6 2.0
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 1.3 1.0 -0.0 1.1 0.6 1.1 0.7
Angina 0.6 0.8 1.7 1.3 -0.1 0.6 -1.2 0.6 0.9
Medication for hormone replacement therapy 0.4 0.4 1.5 -0.4 0.3 -0.4 -0.7 -0.3 -1.2
Vitamin and mineral supplements 6.4 8.7 18.8 3.4 -2.1 3.5 -0.6 4.3 2.2
Supplements: Zinc 7.0 7.6 15.8 -3.1 1.8 -3.7 -0.2 -4.0 -1.7
Medication: Co-codamol 0.2 0.2 1.0 0.0 -0.1 0.2 -1.0 -0.2 -0.1
Medication: Metformin 0.5 0.7 2.1 1.0 0.6 1.5 0.5 0.5 0.6
Diabetes (father) 1.5 1.8 4.3 -2.1 0.4 -1.9 -0.4 -1.5 -0.8
Diabetes (mother) 0.1 0.1 0.4 0.2 -0.2 0.1 0.6 -0.5 0.3
Severe depression (siblings) 0.2 0.2 0.2 -0.4 -0.2 0.5 -0.5 -0.5 -0.4
Pack years adult smoking proportion 1.4 2.1 3.1 1.5 0.8 1.6 1.7 1.7 1.1
Impedance of leg (right) 1.6 7.8 18.7 2.9 -1.3 3.4 1.7 4.3 2.0
Leg fat-free mass (left) 0.2 1.0 2.6 1.6 1.1 0.5 -0.3 -0.2 1.2
Trunk fat percentage 2.4 9.6 16.1 4.0 -0.7 3.8 0.5 3.5 3.8
Hand grip strength (right) 0.0 0.1 0.4 0.2 -0.1 0.0 -0.6 0.6 -0.0
Townsend deprivation index at recruitment 0.3 0.5 0.8 0.4 -0.5 0.9 0.9 0.3 -0.9
Current tobacco smoking 0.2 0.3 0.8 0.0 0.6 -0.1 -0.6 0.9 -0.5
Average weekly fortified wine intake 0.5 0.6 1.7 0.2 1.3 -0.6 0.9 -0.6 -0.6
Maternal smoking around birth 1.9 2.8 5.9 2.3 -0.4 1.4 0.2 1.9 2.4
Fed-up feelings 0.5 0.9 1.9 -0.7 -1.0 -0.8 -0.9 -1.4 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 2.0 2.6 7.5 -1.7 -0.0 -1.9 -1.2 -2.7 -0.7
Relative age voice broke 0.1 0.1 0.3 0.2 -0.1 0.6 -0.1 0.3 0.2
Taking other prescription medications 0.8 1.2 2.0 -1.2 -0.0 -1.4 -0.9 -1.3 -1.3
Age when periods started (menarche) 0.2 0.4 0.9 0.2 0.7 0.9 1.0 -0.1 0.5
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 3.3 -0.8 1.8 -0.2 1.2 -0.1 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 4.5 0.1 2.1 -0.0 -0.1 1.2 -0.0
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 2.6 -1.3 -1.0 -1.6 -1.2 -1.0 -0.1
Qualifications: CSEs or equivalent 0.7 0.9 2.6 0.3 -1.6 -1.0 -1.2 -0.7 0.4
Serious illness, injury or assault to yourself 3.8 4.6 10.7 -2.3 -0.4 -3.3 -0.7 -2.3 -2.4
High blood pressure 1.3 3.6 7.0 2.1 -0.8 2.6 0.9 1.9 2.2
Hayfever, allergic rhinitis or eczema 4.4 9.6 20.9 -3.8 1.2 -3.9 -1.6 -4.6 -1.8
Multivitamins +/- minerals 3.2 4.1 7.2 -2.7 1.1 -2.2 1.0 -2.6 -1.9
Stomach or abdominal pain in last month 1.4 1.8 3.5 -1.6 -0.9 -0.8 -0.7 -1.9 -1.6
Supplements: Glucosamine 7.1 9.2 19.4 -3.7 2.2 -3.5 -0.0 -4.4 -2.4
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.3 0.5 -0.8 0.4 0.9 1.1 0.6
Medication: Atenolol 1.0 1.2 2.4 0.8 -1.2 1.6 -0.1 1.2 1.1
Medication: Levothyroxine sodium 0.2 0.3 0.8 -0.5 0.2 -0.0 -0.6 -0.6 -0.9
Sitting height 1.0 7.3 13.8 3.6 0.1 3.7 -1.1 3.1 2.5
Chronic bronchitis/emphysema (father) 0.2 0.2 0.7 0.2 0.1 0.5 -0.8 0.1 -0.5
High blood pressure (mother) 2.3 3.3 6.2 -1.7 2.1 -2.1 0.5 -2.5 -1.2
Body mass index (BMI) 0.3 1.1 2.7 1.2 0.1 1.3 -0.8 0.5 1.6
Impedance of leg (left) 1.5 7.3 15.2 2.6 -1.5 3.4 1.5 3.9 2.4
Leg predicted mass (left) 0.2 0.9 2.5 1.6 1.1 0.4 -0.2 -0.3 1.1
Trunk fat mass 2.1 9.1 16.4 4.0 -0.2 3.7 0.5 3.2 3.7
Waist circumference 0.3 1.0 3.2 1.3 0.4 0.8 -0.3 0.6 1.8
Number of incorrect matches in round 0.1 0.2 0.9 0.1 0.9 0.2 -0.4 0.5 0.2
Past tobacco smoking 0.4 0.7 1.8 -1.3 0.5 0.1 -1.0 -0.1 -1.1
Alcohol usually taken with meals 7.8 12.5 26.7 -4.7 -0.0 -4.7 0.3 -5.2 -2.0
Nervous feelings 1.9 3.6 9.7 -2.2 -0.1 -2.3 -0.7 -3.1 -1.1
Frequency of tenseness / restlessness in last 2 weeks 1.6 2.5 3.7 -1.4 0.2 -1.9 -1.9 -1.9 -1.4
Hearing difficulty/problems with background noise 1.3 2.2 6.6 -2.1 0.5 -1.0 0.4 -2.6 -0.5
Hair/balding pattern: Pattern 2 0.3 0.3 1.3 0.6 -0.1 -0.4 1.1 0.0 -0.3
Had menopause 0.2 0.3 0.9 0.0 -0.5 0.4 -1.0 0.4 -0.2
Had other major operations 3.6 4.4 11.2 -2.5 0.3 -1.8 1.6 -3.4 -1.7
Forced vital capacity (FVC) 0.1 0.5 2.5 1.6 -0.1 0.5 -0.6 0.2 0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 5.1 -0.6 2.2 -0.3 -0.2 0.9 -0.6
Ever unenthusiastic/disinterested for a whole week 3.5 4.3 14.0 -2.0 0.7 -2.0 1.1 -3.7 -1.4
Qualifications: None of the above 1.7 3.6 7.9 2.3 -0.4 2.8 0.5 2.8 0.5
Financial difficulties in last 2 years 0.6 0.9 2.0 -1.0 -1.0 -0.1 -0.9 -1.4 -0.6
Mouth/teeth dental problems 1.2 1.8 3.7 -1.9 1.1 -1.7 -0.3 -1.1 -1.3
Heart attack 0.5 0.6 2.1 0.6 0.8 0.7 -0.2 0.4 1.4
Allergy 3.5 8.2 17.0 3.5 -1.0 3.4 0.8 4.1 2.4
Pain all over the body in last month 0.7 0.8 2.2 1.1 -0.7 0.7 1.5 0.5 -0.3
Diabetes (self-reported) 1.2 1.9 4.0 1.4 0.4 1.8 2.0 0.7 1.3
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.9 -0.7 1.4 -0.6 -0.3 -0.9 0.6
Medication: Ramipril 0.5 0.6 1.4 1.0 -0.4 1.2 -0.4 0.7 0.8
Medication: Simvastatin 0.6 0.9 2.8 0.9 0.6 1.0 1.7 0.6 0.1
Fluid intelligence score 0.3 0.6 1.3 1.0 0.3 0.0 -1.1 0.9 -0.6
Illnesses of siblings 0.4 0.6 1.0 -0.2 -0.6 -0.5 -1.0 1.0 -0.9
Neuroticism score 4.1 8.6 18.7 -3.5 -0.4 -3.8 -1.0 -4.3 -2.1
Weight 0.8 4.1 7.8 2.8 0.7 2.6 0.1 1.6 2.7
Impedance of arm (right) 1.3 6.3 11.0 3.0 -1.3 2.7 1.9 3.3 2.1
Arm fat percentage (right) 1.3 5.1 8.9 2.9 -0.7 3.0 0.2 2.1 2.9
Trunk fat-free mass 0.1 0.6 2.0 0.8 1.4 0.3 -0.0 -0.8 0.7
Hip circumference 1.1 4.8 9.5 3.1 0.4 2.5 -0.0 2.2 2.9
Time employed in main current job 0.8 1.0 2.5 -1.4 0.2 -1.1 0.1 -1.6 -0.5
Alcohol intake versus 10 years previously 0.1 0.2 0.5 0.7 -0.4 0.2 0.4 -0.3 -0.1
Father’s age at death 0.4 0.6 1.0 -1.0 -0.6 -0.7 0.5 -0.8 -0.8
Worrier / anxious feelings 1.9 3.5 8.9 -2.4 0.3 -2.3 -0.1 -3.0 -1.0
Frequency of tiredness / lethargy in last 2 weeks 4.8 7.8 19.3 -2.9 0.8 -4.4 -1.5 -3.5 -1.9
Falls in the last year 0.2 0.2 0.6 -0.5 -0.4 0.6 0.8 0.2 0.1
Hair/balding pattern: Pattern 3 0.1 0.2 0.8 -0.4 -0.9 0.5 -0.1 0.3 0.1
Number of live births 0.6 0.8 1.7 0.8 -0.9 0.7 1.3 0.4 1.0
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 2.3 0.7 -0.7 -0.2 -1.5 -0.6 -0.0
Pulse rate 1.2 2.0 5.4 -1.0 0.6 -1.3 -2.3 -0.6 -1.8
Happiness 0.6 0.7 1.4 -0.7 0.7 -1.2 0.9 -0.9 -0.4
Noisy workplace 0.3 0.4 1.2 0.2 0.8 0.1 -0.5 -1.1 0.4
Qualifications: A levels/AS levels or equivalent 3.1 6.8 13.8 -3.2 2.1 -3.0 1.0 -3.7 -1.5
Serious illness, injury or assault of a close relative in last 2 years 1.6 1.8 3.3 -1.0 -0.4 -1.8 -1.4 -1.3 -1.7
Mouth/teeth dental problems: Dentures 1.7 2.9 8.2 1.6 -1.8 2.9 0.4 1.6 0.5
Asthma 0.8 1.5 3.9 -1.4 0.6 -0.8 -0.1 -1.5 -2.0
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.2 2.3 -1.0 0.7 -1.1 1.1 -1.5 -0.9
Medication: Cholesterol lowering 2.6 4.1 7.3 2.7 0.5 1.8 2.3 2.7 1.1
Depression (self-reported) 0.3 0.4 1.1 0.0 -0.6 0.4 -1.1 -0.1 0.7
Medication: Lansoprazole 1.2 1.4 2.2 -1.2 0.8 -1.4 -0.7 -1.5 -1.3
Prospective memory result 1.2 1.5 3.5 -1.6 0.6 -1.2 -0.6 -1.9 -0.9
Lung cancer (father) 1.3 1.5 3.1 0.8 -1.6 0.3 -1.7 1.1 1.0
Illnesses of mother 1.7 2.1 5.9 1.3 -1.3 1.7 0.4 2.4 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 2.2 -0.4 -0.3 -1.2 -1.1 -1.4 -1.5
Pulse wave Arterial Stiffness index 1.7 2.0 9.2 -1.1 -0.9 -0.3 -3.0 -0.6 -0.6
Impedance of arm (left) 1.1 5.1 12.2 2.8 -1.2 2.1 1.4 3.5 1.7
Arm fat mass (right) 1.0 4.0 7.4 2.6 -0.2 2.7 -0.0 1.7 2.7
Trunk predicted mass 0.1 0.7 1.8 0.9 1.4 0.4 0.0 -0.7 0.8
Standing height 0.7 6.8 13.9 3.7 1.3 3.0 1.8 2.5 2.7
Length of working week for main job 0.4 0.5 1.1 -0.5 -0.4 -1.0 -0.2 -1.1 0.5
Exposure to tobacco smoke at home 1.3 1.4 3.5 -1.5 -1.0 -0.8 0.1 -1.1 -1.9
Breastfed as a baby 1.0 1.3 2.7 -1.5 0.2 -0.4 -1.0 -1.2 -1.7
Tense / ‘highly strung’ 3.7 6.2 11.0 -3.1 2.1 -3.3 0.1 -2.9 -1.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.9 3.0 6.7 -2.3 0.4 -2.3 0.3 -2.6 -0.7
Hair/balding pattern: Pattern 4 0.3 0.7 3.0 0.4 -0.5 1.7 0.1 0.9 0.4
Birth weight of first child 0.1 0.2 0.6 -0.3 0.4 0.8 0.2 -0.0 -0.1
Peak expiratory flow (PEF) 0.3 0.7 3.5 0.1 0.2 -0.2 -1.9 -0.3 -0.8
Pulse wave reflection index 0.5 0.6 2.6 -0.6 -1.6 0.1 -0.3 -0.4 0.6
Ever highly irritable/argumentative for 2 days 1.4 1.7 4.4 -0.4 0.8 -1.9 1.1 -2.1 0.7
Loud music exposure frequency 0.5 0.5 1.7 -0.6 -0.1 -1.3 -0.4 -0.7 -0.6
Qualifications: O levels/GCSEs or equivalent 0.8 1.2 3.4 -1.1 0.7 -1.3 -0.8 -1.8 0.0
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 1.5 0.2 -0.4 -0.1 0.0 -0.3 1.2
Blood clot in the leg (DVT) 0.3 0.4 1.4 -0.3 0.2 -0.5 1.2 -0.1 -0.6
Medication: Paracetamol 1.0 1.7 3.4 -1.3 -0.9 -1.8 -1.0 -1.7 -0.1
Headache pain in last month 0.4 0.7 2.1 -0.4 -0.2 -0.5 -1.1 -1.5 -0.4
Medication for cholesterol, blood pressure or diabetes 2.7 4.4 6.7 -2.5 0.0 -2.1 -2.4 -2.6 -1.9
Glaucoma (self-reported) 0.7 0.9 3.3 -0.8 0.9 -0.1 1.8 -0.4 -0.4
Gout (self-reported) 2.7 3.6 10.0 1.8 -0.7 3.2 1.6 2.1 0.9
Hypothyroidism/myxoedema (self-reported) 0.9 1.8 3.0 -1.7 -0.7 -0.9 -1.2 -1.5 -1.7
Medication: Amlodipine 0.2 0.3 0.9 0.8 -0.3 0.2 1.0 0.4 0.4
Medication: Ventolin 100micrograms inhaler 0.7 0.9 2.1 -1.1 0.2 -0.3 -0.9 -1.1 -1.5
Birth weight 0.2 0.3 1.0 0.8 1.0 0.3 -0.2 0.4 0.0
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.0 -0.8 0.5 -0.9 -0.2 -1.0 -0.9
High blood pressure (siblings) 0.9 1.3 4.5 -0.2 2.1 0.4 1.4 -0.8 0.6
Forced vital capacity (FVC), Best measure 0.1 0.5 1.9 0.3 0.3 -0.6 -0.3 -0.7 -1.4
Body fat percentage 2.3 8.9 14.2 3.7 -0.9 3.8 0.4 3.3 3.8
Leg fat percentage (right) 1.9 6.9 13.3 2.9 -0.9 3.7 0.2 3.1 3.1
Arm fat-free mass (right) 0.1 0.7 1.3 1.1 1.1 0.7 -0.4 -0.1 1.1
Exposure to tobacco smoke outside home 0.5 0.7 2.5 -0.0 -1.6 0.5 0.4 0.5 0.9
Comparative body size at age 10 3.5 9.7 20.8 4.2 -0.6 3.2 -1.4 4.6 2.8
Number of full brothers 2.0 2.5 4.2 -2.0 -1.5 -1.8 -1.3 -1.8 -0.5
Worry too long after embarrassment 2.9 4.9 10.4 -2.9 0.7 -3.2 0.1 -2.8 -1.6
Seen a psychiatrist for nerves, anxiety, tension or depression 2.6 3.3 9.9 -2.4 0.4 -2.0 -0.2 -3.1 -0.1
Wheeze or whistling in the chest in last year 1.3 2.4 3.7 -1.7 1.5 -1.9 -1.0 -1.3 -1.6
Number of children fathered 4.1 4.6 11.6 1.7 -2.0 3.4 1.8 1.8 1.5
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 2.2 0.4 -0.8 1.3 0.2 0.9 1.5
Age at first live birth 0.5 0.9 1.8 -0.6 1.4 -1.3 -0.4 -0.8 -0.9
Pulse wave peak to peak time 2.1 2.5 9.7 1.5 1.0 0.6 3.1 0.9 0.8
Health satisfaction 1.0 1.3 4.0 -1.2 0.9 -1.1 0.6 -2.0 -0.6
Shortness of breath walking on level ground 0.4 0.5 1.0 -0.7 0.2 -0.8 -0.7 -1.0 0.3
Qualifications: College or University degree 1.4 4.4 7.6 -2.8 2.0 -2.7 1.5 -2.2 -0.8
Eye problems/disorders: None of the above 1.3 1.5 3.2 -1.1 -1.8 -1.1 -1.2 -1.3 -0.5
Mouth/teeth dental problems: Loose teeth 1.0 1.2 3.5 -0.8 -0.7 -0.6 1.9 -1.0 -1.2
Emphysema/chronic bronchitis 0.3 0.4 0.8 -0.8 0.5 -0.9 0.1 -0.8 -0.4
Medication for pain relief, constipation, heartburn 0.8 1.4 3.7 1.5 -0.0 1.9 -0.2 1.4 0.7
Neck or shoulder pain in last month 0.6 0.8 1.9 1.3 -0.3 0.6 -0.3 0.9 1.4
Medication: Blood pressure 2.8 4.9 7.6 2.5 -0.5 2.6 1.3 2.6 2.8
Angina (self-reported) 0.7 0.9 2.0 1.4 -0.3 0.6 -1.2 0.6 1.1
Migraine (self-reported) 0.5 0.6 1.4 -0.7 -0.6 -0.5 0.2 -1.0 -1.2
Medication: Ibuprofen 0.8 1.0 1.9 -0.7 1.3 -0.6 1.4 -1.0 -0.6
Medication: Allopurinol 5.5 7.3 14.6 3.1 -0.6 3.8 2.4 3.3 1.8
Medication: Omeprazole 0.2 0.2 0.5 0.5 0.4 0.4 -0.7 -0.1 0.5
Medication: Seretide 50 evohaler 2.8 3.3 8.1 -2.4 1.7 -1.6 0.0 -2.8 -0.5
Mean time to correctly identify matches 1.8 3.4 7.0 -2.0 0.3 -1.2 2.7 -2.6 -1.2
Heart disease (mother) 0.6 0.7 2.3 -1.1 0.1 -0.5 -0.6 -1.5 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.2 -0.1 0.3 -1.1 -0.2 -0.1 1.0
Whole body fat mass 1.7 7.1 12.0 3.5 -0.3 3.4 0.3 2.7 3.4
Leg fat mass (right) 1.3 5.1 9.7 2.8 -0.3 3.1 -0.3 2.2 2.8
Arm predicted mass (right) 0.1 0.7 1.4 1.0 1.2 0.6 -0.8 -0.1 1.0
Pulse rate, automated reading 1.4 4.4 7.1 -2.4 0.9 -2.7 -2.3 -2.2 -1.4
Alcohol intake frequency. 1.4 3.2 8.1 -2.2 -0.4 -0.9 -0.4 -2.9 -2.2
Comparative height size at age 10 0.2 1.3 3.4 1.5 -0.9 1.8 0.2 1.1 0.6
Number of full sisters 0.3 0.3 1.3 1.1 0.1 0.6 0.3 0.5 -0.2
Suffer from ‘nerves’ 1.0 1.5 4.4 -1.1 -0.4 -1.2 -0.1 -1.4 -2.1
Overall health rating 1.1 2.4 3.8 -1.3 1.8 -1.8 -0.7 -2.0 -1.5
Chest pain or discomfort 2.8 4.0 7.5 -2.7 1.6 -2.0 -0.2 -2.5 -1.9
Had major operations 0.1 0.1 0.2 -0.1 -0.4 -0.4 0.3 -0.4 0.5
Age at last live birth 1.1 1.6 3.9 -1.0 1.1 -2.0 0.1 -1.8 -0.4
Family relationship satisfaction 2.7 3.3 7.8 -2.5 1.4 -1.8 0.3 -2.8 -0.7
Leg pain on walking 0.5 0.7 2.2 0.1 1.5 0.1 -0.7 -0.7 1.0
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.6 8.1 -0.5 -2.9 -0.0 -0.7 -0.8 -0.1
Commuting to job workplace: Car/motor vehicle 1.8 2.1 6.8 0.6 -1.4 0.3 -2.6 0.1 1.8
Illness, injury, bereavement, stress in last 2 years 2.5 3.0 5.1 1.4 0.8 1.6 1.9 2.1 2.3
Medication: Aspirin 0.6 0.7 1.5 0.8 0.1 0.7 1.2 1.0 0.8
Supplements: Vitamin C 2.1 2.5 5.8 -1.7 1.0 -2.3 0.4 -2.4 -0.5
Knee pain experienced in last month 1.4 2.2 6.2 -1.6 -0.4 -1.8 0.3 -2.5 1.0
Hypertension (Self-reported) 1.3 3.5 5.7 2.1 -0.4 2.4 1.2 1.9 2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.3 -0.2 0.2 -0.6 -0.1 0.2 -0.4
Illnesses of father: Heart disease 0.5 0.7 2.7 -0.1 -0.4 -1.1 0.3 -1.6 0.5
Illnesses of siblings: Diabetes 0.6 0.8 3.7 0.4 -1.9 0.8 0.1 -0.3 -0.2
Smoking status: Previous 0.8 1.2 3.0 1.7 0.0 0.1 1.4 0.4 1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.7 2.0 1.4 0.0 -0.2 -0.7 0.9 -0.7
Whole body fat-free mass 0.1 0.8 1.9 1.1 1.4 0.3 -0.3 -0.7 0.9
Leg fat-free mass (right) 0.1 0.7 1.3 1.1 1.1 -0.0 -0.5 -0.9 1.0
Arm fat percentage (left) 1.2 4.7 8.0 2.8 -0.6 2.7 -0.1 2.2 2.7
Average weekly red wine intake 2.8 4.2 9.3 -2.3 1.4 -3.1 1.4 -2.5 -0.6
Handedness (chirality/laterality): Left-handed 0.8 0.9 2.5 -0.3 0.4 -1.3 -0.4 -1.6 -0.9
Mood swings 2.7 4.8 10.6 -2.6 -0.1 -2.4 -2.3 -3.3 -0.7
Loneliness, isolation 2.0 2.8 6.3 -1.9 -1.3 -1.8 -0.8 -2.5 -1.3
Long-standing illness, disability or infirmity 3.1 4.7 9.7 -2.2 0.3 -2.8 -0.8 -3.1 -2.3
Ever had bowel cancer screening 0.3 0.4 1.3 -0.4 0.8 -0.0 1.1 -0.5 0.2
Diabetes diagnosed by doctor 0.7 1.1 2.5 0.9 0.5 1.6 1.3 0.7 0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.2 -0.5 1.1 -0.9 0.6 -1.0 0.4
Friendships satisfaction 0.2 0.3 0.7 -0.7 0.3 -0.6 0.3 -0.8 0.2
Qualifications: nursing, teaching 1.7 2.6 6.6 -1.8 0.3 -2.6 -0.2 -2.5 -0.1
Commuting to job workplace: Walk 1.4 1.5 4.0 -0.8 0.9 0.3 1.9 0.0 -2.0
Eye problems/disorders: Cataract 1.0 1.2 3.3 -0.7 1.1 -1.0 -1.8 -1.0 0.3
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 3.9 -0.1 2.0 -1.6 0.7 -1.0 1.2
Medication for cholesterol 0.7 1.1 2.9 -0.6 0.2 -1.5 -1.7 -1.0 -0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.6 -0.7 -0.2 -0.2 0.5 -0.8 -0.4
Back pain experienced in last month 0.6 0.9 1.9 -1.2 -0.8 -0.6 -0.5 -1.4 -0.7
Mineral and other dietary supplements 8.8 11.9 24.5 5.0 -0.8 3.6 0.3 4.9 3.1
Breast cancer (self-reported) 2.1 2.5 5.1 -1.8 1.4 -2.3 0.0 -2.0 -0.9
Asthma (self-reported) 0.6 1.3 3.6 -1.1 0.4 -0.8 -0.1 -1.4 -1.9
Osteoporosis (self-reported) 1.1 1.4 4.0 -0.7 -1.0 -1.6 -0.3 0.4 -2.0
Osteoarthritis (self-reported) 0.3 0.3 0.9 -0.5 0.9 0.3 0.3 -0.7 -0.5
Medication: Aspirin 0.7 0.9 1.3 1.0 -0.2 0.8 1.0 1.2 1.1
Medication: Gliclazide 3.1 3.5 7.5 2.3 0.6 2.7 -0.3 1.7 2.2
Illnesses of father: None of the above (group 1) 0.0 0.1 0.1 0.0 0.0 0.2 -0.3 0.4 0.2
Smoking status: Current 0.2 0.3 0.7 -0.1 0.1 -0.2 -0.8 0.7 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.4 5.2 -1.8 -0.7 -1.6 -1.0 -2.3 -1.4
Whole body water mass 0.1 0.8 2.1 1.0 1.5 0.3 -0.2 -0.7 0.9
Leg predicted mass (right) 0.1 0.7 1.4 1.0 1.2 -0.2 -0.4 -1.0 1.0
Arm fat mass (left) 1.1 4.5 7.7 2.8 -0.2 2.8 -0.3 2.0 2.7
Number of self-reported non-cancer illnesses 0.7 1.3 3.1 -1.3 0.3 -0.2 0.4 -1.8 -1.6
Average weekly champagne plus white wine intake 1.3 1.7 5.8 0.5 2.4 -0.9 1.8 0.3 0.5
Miserableness 1.9 3.3 9.1 -2.1 -0.6 -2.2 -0.6 -3.0 -0.8
Guilty feelings 5.2 7.8 17.0 -3.2 -0.2 -4.1 -1.6 -2.9 -2.8
Wears glasses or contact lenses 2.5 2.9 5.9 -2.4 1.1 -1.0 -1.0 -1.6 -2.4
Ever taken oral contraceptive pill 0.1 0.2 0.3 0.5 0.4 -0.1 0.5 0.5 0.3
Hearing aid user 1.0 1.1 4.5 0.7 -0.3 -0.1 2.1 -0.0 1.3
Mother’s age at death 0.2 0.3 0.9 -0.5 -0.9 -0.4 0.0 -0.4 -0.5
Financial situation satisfaction 1.0 1.3 2.4 1.5 -0.1 0.7 1.5 0.7 1.6
Tinnitus: Yes, now most or all of the time 0.9 1.0 3.7 -0.1 0.1 0.0 1.9 -1.2 1.1
Commuting to job workplace: Public transport 1.3 1.6 5.1 -0.2 2.3 -0.7 1.8 0.1 -0.5
Eye problems/disorders: Glaucoma 0.8 0.9 1.7 0.3 -0.7 1.3 1.3 1.2 0.2
Medication: Blood pressure 0.4 0.7 3.8 0.0 -0.0 0.4 1.9 -0.2 0.4
Pain type(s) experienced in last month: Hip pain 0.9 1.1 3.1 0.0 1.5 -0.4 -1.8 -0.7 -0.6
Supplements: Fish oil (including cod liver oil) 5.1 6.7 15.1 -3.8 -0.0 -2.8 -0.3 -3.9 -1.6
High cholesterol (Self-reported) 1.0 1.8 3.6 1.3 -0.0 1.9 1.7 1.6 -0.3
Medication: Bendroflumethiazide 0.6 0.9 3.3 0.4 1.0 0.5 1.8 -0.4 0.5
Medication: Paracetamol 1.7 2.6 5.4 -1.8 -0.9 -2.3 -1.2 -2.1 -0.2
Medication: Lisinopril 0.8 1.0 2.9 1.2 -0.5 0.4 -0.4 1.1 1.7
Medication: Atorvastatin 1.6 2.0 4.6 1.5 -0.9 1.8 0.8 2.1 0.6
Illnesses of father: High blood pressure 0.3 0.4 0.8 -0.7 -0.4 -0.5 0.8 -0.9 -0.4
Alcohol drinker status: Never 0.6 0.7 1.9 -0.3 -0.5 1.4 -1.0 0.1 -0.8
Ever smoked 0.5 0.8 2.4 -0.3 0.3 -1.5 0.1 -1.5 0.0
Basal metabolic rate 0.2 1.2 2.7 1.6 1.2 1.0 -0.1 -0.1 1.5
Leg fat percentage (left) 1.7 6.2 12.1 2.6 -0.8 3.5 0.1 2.6 3.2
Arm fat-free mass (left) 0.2 1.0 2.0 1.2 1.1 1.0 -0.4 -0.1 1.4
Number of operations (self-reported) 0.8 1.2 2.6 -0.9 0.8 -0.7 1.5 -1.6 -0.1
Average weekly beer plus cider intake 2.2 3.1 4.9 1.8 -0.6 2.2 -2.1 2.1 1.1
Irritability 1.9 3.2 7.5 -1.9 0.7 -2.7 0.7 -2.7 -0.1
Risk taking 0.8 1.1 4.1 -1.1 2.0 -0.9 0.2 -0.7 -0.4
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.3 -0.6 0.4 -0.4 1.1 0.6 -0.0
Fractured/broken bones in last 5 years 0.9 1.1 2.3 1.2 1.5 1.0 0.7 1.0 -0.7
Age started oral contraceptive pill 1.2 1.6 8.5 -0.7 0.1 0.4 2.9 -0.4 -0.2
Diastolic blood pressure, automated reading 0.7 2.1 5.1 1.5 -0.5 2.1 -0.3 0.7 2.3
Ever depressed for a whole week 2.9 3.5 7.2 -2.2 0.2 -2.0 1.0 -2.7 -1.9
Unable to work because of sickness or disability 0.6 0.8 1.7 -0.5 -1.1 -1.0 -0.6 -1.3 -0.1
Commuting to job workplace: Cycle 1.3 1.5 2.9 -1.0 1.3 -1.4 -0.2 -1.7 -1.3
Myopia 1.8 2.6 5.2 -2.3 -0.7 -1.8 -0.8 -2.1 -1.3
Vascular/heart problems diagnosed by doctor 1.1 2.9 6.8 -1.7 0.3 -2.6 -0.8 -1.6 -2.1
Cholesterol lowering medication 0.5 0.7 2.5 0.0 -0.6 1.6 1.1 0.1 0.4
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.5 0.6 -0.1 0.5 -0.7 0.1 0.0
Pain experienced in last month 0.3 0.5 1.4 0.7 -1.0 0.4 -0.1 1.2 0.2
Supplements: Calcium 2.5 2.8 5.1 -1.7 2.1 -1.8 -0.7 -2.3 -0.9
Basal cell carcinoma (self-reported) 0.2 0.3 0.9 -0.5 -0.9 -0.3 0.6 -0.4 -0.3
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.7 0.5 0.5 0.7 -0.2 0.3 1.3
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 1.1 -0.2 0.0 -0.6 1.0 0.0 -0.6
Heart disease (siblings) 0.4 0.4 1.0 -0.5 -0.2 -0.4 -0.8 -1.0 0.8
Alcohol drinker status: Previous 0.3 0.3 0.7 0.5 0.2 0.9 -0.1 0.6 -0.5
Pack years of smoking 1.3 1.9 3.1 1.2 0.9 1.7 1.8 1.4 1.0
Impedance of whole body 1.7 8.5 19.4 3.3 -1.7 3.2 1.5 4.4 2.3
Leg fat mass (left) 1.3 5.3 9.7 2.8 -0.4 3.1 -0.3 2.1 3.1
Arm predicted mass (left) 0.2 0.9 1.9 1.1 1.4 0.8 -0.3 -0.2 1.2