Hub : Traits :

Medication: Ibuprofen (e.g. Nurofen)

8 significantly associated models · 6 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 6 12020241 13990267 2 1 2.7e-09 4.5e-09 1.0000 100 RP1-257A7.5
2 12 56805309 58303535 3 2 7.0e-14 4.8e-14 1.0000 100 LRP1 STAT6
3 17 42814955 43913030 1 1 2.3e-07 6.3e-07 0.0041 67 PLEKHM1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Major Depression (MDD) 2.83 1 0 0.0 0.00 1.0e+00 PLEKHM1
Verbal and Numeric Reasoning (VNR) 1.96 1 0 0.0 0.00 1.0e+00 PLEKHM1
Breast Cancer 2.27 1 0 0.0 0.00 1.0e+00 PLEKHM1
Coronary Artery Disease (CAD) 9.49 1 1 3.0 0.00 1.0e+00 RP1-257A7.5
Neuroticism 3.34 1 0 0.0 0.00 1.0e+00 PLEKHM1
Primary Biliary Cirrhosis 5.78 3 0 0.0 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Schizophrenia 2.94 2 0 0.0 0.00 1.0e+00 PLEKHM1 STAT6
Blood Eosinophil Count 3.67 3 2 6.1 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Blood Platelet Count 0.52 1 0 0.0 0.00 1.0e+00 LRP1
Blood Red Count 5.75 2 1 3.0 0.00 1.0e+00 PLEKHM1 RP1-257A7.5
Blood White Count 0.94 1 0 0.0 0.00 1.0e+00 PLEKHM1
BMI 1.42 1 0 0.0 0.00 1.0e+00 LRP1
Height 1.68 3 2 6.1 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Waist Hip Ratio (WHR) 3.04 1 1 3.0 0.00 1.0e+00 PLEKHM1
Systolic Blood Pressure 3.51 2 2 6.1 0.00 1.0e+00 PLEKHM1 RP1-257A7.5
Allergy or Eczema 4.36 2 0 0.0 0.00 1.0e+00 LRP1 STAT6
Respiratory disease 11.79 2 2 6.1 0.00 1.0e+00 LRP1 STAT6
Lung FEV1/FVC ratio 8.83 3 2 6.1 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Lung FVC 2.47 1 1 3.0 0.00 1.0e+00 PLEKHM1
Neuroticism 8.02 3 1 3.0 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Hair Pigment 0.22 1 0 0.0 0.00 1.0e+00 LRP1
Tanning 0.27 1 0 0.0 0.00 1.0e+00 PLEKHM1
Hand grip strength (left) 3.65 1 1 3.0 0.00 1.0e+00 RP1-257A7.5
Number of treatments/medications taken 5.36 2 0 0.0 0.00 1.0e+00 LRP1 RP1-257A7.5
Sensitivity / hurt feelings 7.80 2 1 3.0 0.00 1.0e+00 LRP1 PLEKHM1
Frequency of depressed mood in last 2 weeks 3.13 1 0 0.0 0.00 1.0e+00 PLEKHM1
Relative age of first facial hair 4.22 1 1 3.0 0.00 1.0e+00 PLEKHM1
Systolic blood pressure, automated reading 4.74 2 0 0.0 0.00 1.0e+00 PLEKHM1 RP1-257A7.5
Angina 6.51 1 1 3.0 0.00 1.0e+00 RP1-257A7.5
Vitamin and mineral supplements 8.98 2 1 3.0 0.00 1.0e+00 LRP1 STAT6
Impedance of leg (right) 1.80 1 1 3.0 0.00 1.0e+00 PLEKHM1
Leg fat-free mass (left) 1.96 2 0 0.0 0.00 1.0e+00 PLEKHM1 STAT6
Trunk fat percentage 2.01 3 0 0.0 0.00 1.0e+00 LRP1 PLEKHM1 RP1-257A7.5
Hand grip strength (right) 4.89 3 0 0.0 0.00 1.0e+00 LRP1 RP1-257A7.5 STAT6
Fed-up feelings 4.89 1 1 3.0 0.00 1.0e+00 PLEKHM1
Frequency of unenthusiasm / disinterest in last 2 weeks 2.49 1 0 0.0 0.00 1.0e+00 PLEKHM1
Relative age voice broke 3.02 1 0 0.0 0.00 1.0e+00 PLEKHM1
Age when periods started (menarche) 1.53 1 0 0.0 0.00 1.0e+00 PLEKHM1
High blood pressure 1.45 2 0 0.0 0.00 1.0e+00 PLEKHM1 RP1-257A7.5
Hayfever, allergic rhinitis or eczema 4.71 2 0 0.0 0.00 1.0e+00 LRP1 STAT6
Multivitamins +/- minerals 4.56 1 0 0.0 0.00 1.0e+00 LRP1
Sitting height 3.36 2 2 6.1 0.00 1.0e+00 LRP1 STAT6
High blood pressure (mother) 3.46 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Body mass index (BMI) 1.07 1 0 0.0 0.00 1.0e+00 LRP1
Impedance of leg (left) 1.79 1 1 3.0 0.00 1.0e+00 PLEKHM1
Leg predicted mass (left) 2.01 2 0 0.0 0.00 1.0e+00 PLEKHM1 STAT6
Nervous feelings 3.92 1 1 3.0 0.00 1.0e+00 PLEKHM1
Frequency of tenseness / restlessness in last 2 weeks 6.94 1 1 3.0 0.00 1.0e+00 PLEKHM1
Hearing difficulty/problems with background noise 3.10 1 0 0.0 0.00 1.0e+00 PLEKHM1
Hair/balding pattern: Pattern 2 3.98 1 0 0.0 0.00 1.0e+00 PLEKHM1
Forced vital capacity (FVC) 1.80 2 0 0.0 0.00 1.0e+00 PLEKHM1 STAT6
Ever unenthusiastic/disinterested for a whole week 4.90 1 0 0.0 0.00 1.0e+00 PLEKHM1
Qualifications: None of the above 1.04 1 0 0.0 0.00 1.0e+00 LRP1
Mouth/teeth dental problems 2.32 1 0 0.0 0.00 1.0e+00 PLEKHM1
Heart attack 11.98 1 1 3.0 0.00 1.0e+00 RP1-257A7.5
Allergy 7.97 3 1 3.0 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Hayfever/allergic rhinitis (self-reported) 6.93 2 0 0.0 0.00 1.0e+00 LRP1 STAT6
Fluid intelligence score 4.02 3 0 0.0 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Neuroticism score 6.65 1 1 3.0 0.00 1.0e+00 PLEKHM1
Weight 0.84 1 0 0.0 0.00 1.0e+00 PLEKHM1
Impedance of arm (right) 2.31 1 1 3.0 0.00 1.0e+00 PLEKHM1
Arm fat percentage (right) 1.57 1 0 0.0 0.00 1.0e+00 LRP1
Trunk fat-free mass 4.11 3 2 6.1 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Worrier / anxious feelings 3.48 1 0 0.0 0.00 1.0e+00 PLEKHM1
Hair/balding pattern: Pattern 3 3.84 1 0 0.0 0.00 1.0e+00 PLEKHM1
Forced expiratory volume in 1-second (FEV1) 0.96 1 0 0.0 0.00 1.0e+00 PLEKHM1
Qualifications: A levels/AS levels or equivalent 2.46 1 0 0.0 0.00 1.0e+00 PLEKHM1
Asthma 9.35 2 1 3.0 0.00 1.0e+00 LRP1 STAT6
Prospective memory result 2.42 1 0 0.0 0.00 1.0e+00 LRP1
Forced expiratory volume in 1-second (FEV1), Best measure 0.99 1 0 0.0 0.00 1.0e+00 PLEKHM1
Pulse wave Arterial Stiffness index 5.13 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Impedance of arm (left) 2.73 2 1 3.0 0.00 1.0e+00 PLEKHM1 STAT6
Trunk predicted mass 4.16 3 2 6.1 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Standing height 2.24 3 2 6.1 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Hair/balding pattern: Pattern 4 8.42 1 1 3.0 0.00 1.0e+00 PLEKHM1
Birth weight of first child 1.99 1 0 0.0 0.00 1.0e+00 STAT6
Pulse wave reflection index 2.68 1 0 0.0 0.00 1.0e+00 LRP1
Medication: Paracetamol 22.35 4 2 6.1 0.99 1.4e-02 LRP1 PLEKHM1 RP1-257A7.5 STAT6
Headache pain in last month 50.97 4 4 12.1 0.99 1.4e-02 LRP1 PLEKHM1 RP1-257A7.5 STAT6
Gout (self-reported) 3.22 1 0 0.0 0.00 1.0e+00 LRP1
Medication: Ventolin 100micrograms inhaler 5.15 1 0 0.0 0.00 1.0e+00 STAT6
Birth weight 3.96 3 0 0.0 0.00 1.0e+00 LRP1 RP1-257A7.5 STAT6
High blood pressure (siblings) 2.68 1 0 0.0 0.00 1.0e+00 LRP1
Forced vital capacity (FVC), Best measure 1.79 2 0 0.0 0.00 1.0e+00 PLEKHM1 STAT6
Body fat percentage 2.12 2 0 0.0 0.00 1.0e+00 LRP1 RP1-257A7.5
Leg fat percentage (right) 2.53 1 0 0.0 0.00 1.0e+00 LRP1
Arm fat-free mass (right) 2.80 2 1 3.0 0.00 1.0e+00 PLEKHM1 STAT6
Worry too long after embarrassment 2.18 1 0 0.0 0.00 1.0e+00 PLEKHM1
Pulse wave peak to peak time 4.35 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Qualifications: College or University degree 1.72 1 0 0.0 0.00 1.0e+00 PLEKHM1
Medication for pain relief, constipation, heartburn 22.01 4 2 6.1 -0.98 2.1e-02 LRP1 PLEKHM1 RP1-257A7.5 STAT6
Angina (self-reported) 6.55 1 1 3.0 0.00 1.0e+00 RP1-257A7.5
Migraine (self-reported) 43.56 3 3 9.1 0.00 1.0e+00 LRP1 RP1-257A7.5 STAT6
Medication: Ibuprofen 25.63 4 3 9.1 1.00 4.9e-05 LRP1 PLEKHM1 RP1-257A7.5 STAT6
Medication: Seretide 50 evohaler 3.89 1 0 0.0 0.00 1.0e+00 STAT6
Heart disease (mother) 4.35 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Leg fat mass (right) 0.91 1 0 0.0 0.00 1.0e+00 LRP1
Arm predicted mass (right) 2.95 2 1 3.0 0.00 1.0e+00 PLEKHM1 STAT6
Pulse rate, automated reading 1.25 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Alcohol intake frequency. 8.76 4 0 0.0 0.99 1.3e-02 LRP1 PLEKHM1 RP1-257A7.5 STAT6
Had major operations 3.35 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Knee pain experienced in last month 2.37 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Hypertension (Self-reported) 1.49 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Illnesses of father: Heart disease 9.86 2 1 3.0 0.00 1.0e+00 PLEKHM1 RP1-257A7.5
Forced expiratory volume in 1-second (FEV1), predicted 2.12 1 0 0.0 0.00 1.0e+00 STAT6
Whole body fat-free mass 3.25 3 2 6.1 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Leg fat-free mass (right) 2.30 2 1 3.0 0.00 1.0e+00 PLEKHM1 STAT6
Arm fat percentage (left) 1.72 2 0 0.0 0.00 1.0e+00 LRP1 RP1-257A7.5
Handedness (chirality/laterality): Left-handed 2.45 1 0 0.0 0.00 1.0e+00 PLEKHM1
Mood swings 7.38 2 1 3.0 0.00 1.0e+00 LRP1 PLEKHM1
Loneliness, isolation 3.42 1 0 0.0 0.00 1.0e+00 PLEKHM1
Mouth/teeth dental problems: Mouth ulcers 4.16 1 0 0.0 0.00 1.0e+00 PLEKHM1
Back pain experienced in last month 3.39 1 0 0.0 0.00 1.0e+00 LRP1
Mineral and other dietary supplements 5.46 2 0 0.0 0.00 1.0e+00 LRP1 STAT6
Asthma (self-reported) 9.86 2 1 3.0 0.00 1.0e+00 LRP1 STAT6
Medication: Aspirin 2.08 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Illnesses of father: None of the above (group 1) 3.36 2 0 0.0 0.00 1.0e+00 PLEKHM1 RP1-257A7.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.58 1 0 0.0 0.00 1.0e+00 PLEKHM1
Whole body water mass 3.32 3 2 6.1 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Leg predicted mass (right) 2.32 2 1 3.0 0.00 1.0e+00 PLEKHM1 STAT6
Miserableness 5.25 3 0 0.0 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Guilty feelings 2.56 1 0 0.0 0.00 1.0e+00 PLEKHM1
Medication: Blood pressure 1.80 1 0 0.0 0.00 1.0e+00 PLEKHM1
Supplements: Fish oil (including cod liver oil) 5.56 2 0 0.0 0.00 1.0e+00 LRP1 STAT6
Medication: Bendroflumethiazide 2.05 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Medication: Paracetamol 17.85 4 1 3.0 0.98 1.9e-02 LRP1 PLEKHM1 RP1-257A7.5 STAT6
Basal metabolic rate 2.55 2 1 3.0 0.00 1.0e+00 PLEKHM1 STAT6
Leg fat percentage (left) 2.43 1 0 0.0 0.00 1.0e+00 LRP1
Arm fat-free mass (left) 2.91 2 1 3.0 0.00 1.0e+00 PLEKHM1 STAT6
Number of operations (self-reported) 3.34 1 0 0.0 0.00 1.0e+00 LRP1
Average weekly beer plus cider intake 5.22 2 0 0.0 0.00 1.0e+00 LRP1 STAT6
Irritability 1.74 1 0 0.0 0.00 1.0e+00 PLEKHM1
Diastolic blood pressure, automated reading 0.98 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Myopia 6.61 2 0 0.0 0.00 1.0e+00 LRP1 STAT6
Pain experienced in last month 12.76 4 1 3.0 -0.99 1.1e-02 LRP1 PLEKHM1 RP1-257A7.5 STAT6
Supplements: Calcium 3.56 1 0 0.0 0.00 1.0e+00 LRP1
Heart attack/myocardial infarction (self-reported) 12.43 1 1 3.0 0.00 1.0e+00 RP1-257A7.5
Heart disease (siblings) 7.35 2 1 3.0 0.00 1.0e+00 PLEKHM1 RP1-257A7.5
Impedance of whole body 2.75 2 1 3.0 0.00 1.0e+00 PLEKHM1 STAT6
Leg fat mass (left) 0.88 1 0 0.0 0.00 1.0e+00 LRP1
Arm predicted mass (left) 2.76 2 1 3.0 0.00 1.0e+00 PLEKHM1 STAT6

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.27
GTEx Adipose Visceral Omentum 0 0.0000 1.42
GTEx Adrenal Gland 1 0.0686 1.36
GTEx Artery Aorta 2 0.0672 1.31
GTEx Artery Coronary 1 0.0845 1.40
GTEx Artery Tibial 2 0.0532 1.35
GTEx Brain Caudate basal ganglia 0 0.0000 1.29
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.42
GTEx Brain Cerebellum 0 0.0000 1.34
GTEx Brain Cortex 0 0.0000 1.35
GTEx Brain Frontal Cortex BA9 0 0.0000 1.40
GTEx Brain Hippocampus 0 0.0000 1.33
GTEx Brain Hypothalamus 0 0.0000 1.36
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.38
GTEx Brain Putamen basal ganglia 0 0.0000 1.38
GTEx Breast Mammary Tissue 0 0.0000 1.33
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.34
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.26
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.40
GTEx Cells Transformed fibroblasts 0 0.0000 1.30
GTEx Colon Sigmoid 0 0.0000 1.29
GTEx Colon Transverse 0 0.0000 1.35
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.33
GTEx Esophagus Mucosa 0 0.0000 1.37
GTEx Esophagus Muscularis 0 0.0000 1.33
GTEx Heart Atrial Appendage 0 0.0000 1.34
GTEx Heart Left Ventricle 0 0.0000 1.37
GTEx Liver 0 0.0000 1.33
GTEx Lung 0 0.0000 1.29
GTEx Muscle Skeletal 0 0.0000 1.30
GTEx Nerve Tibial 0 0.0000 1.27
GTEx Ovary 0 0.0000 1.41
GTEx Pancreas 0 0.0000 1.32
GTEx Pituitary 0 0.0000 1.29
GTEx Prostate 0 0.0000 1.36
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.35
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.32
GTEx Small Intestine Terminal Ileum 0 0.0000 1.55
GTEx Spleen 0 0.0000 1.29
GTEx Stomach 0 0.0000 1.39
GTEx Testis 0 0.0000 1.35
GTEx Thyroid 0 0.0000 1.30
GTEx Uterus 0 0.0000 1.44
GTEx Vagina 0 0.0000 1.31
GTEx Whole Blood 0 0.0000 1.24
METSIM Adipose 2 0.0434 1.19
NTR Blood 0 0.0000 1.26
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.26
YFS Blood 0 0.0000 1.18
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.27
TCGA Breast Tumor 0 0.0000 1.26
TCGA Breast Normal 0 0.0000 1.22
TCGA Ovarian Tumor 0 0.0000 1.19
TCGA Prostate Tumor 0 0.0000 1.23