Hub : Traits :

Illnesses of father: Heart disease

48 significantly associated models · 15 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 109098737 110517617 2 1 4.1e-12 3.2e-12 1.0e+00 100 PSRC1
2 1 222096959 223537385 2 1 9.9e-09 5.5e-09 9.7e-02 92 RP11-378J18.8
3 6 12020241 13990267 2 1 2.0e-10 1.1e-11 1.0e+00 100 RP1-257A7.5
4 6 160071844 161571560 1 1 7.4e-13 3.4e-14 3.3e-12 16 SLC22A3
5 7 43719868 45228018 1 1 2.8e-08 1.7e-07 1.0e+00 100 NUDCD3
6 9 21303958 22819407 2 2 1.0e-20 3.3e-41 8.0e-21 52 CDKN2B CDKN2B-AS1
7 15 78360691 79802863 1 1 6.7e-08 5.4e-07 1.6e-03 60 ADAMTS7
8 15 90730363 92135418 1 1 3.1e-12 5.1e-11 4.9e-01 99 FES
9 16 81966047 84527021 1 1 2.8e-08 2.1e-08 1.6e-01 94 CDH13
10 19 17138985 18594836 2 1 3.2e-07 3.1e-07 1.0e+00 100 FCHO1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 1.24 1 0 0.0 0.00 1.0e+00 FES
Irritable Bowel Disease (IBD) 0.95 1 0 0.0 0.00 1.0e+00 FES
Major Depression (MDD) 2.32 1 0 0.0 0.00 1.0e+00 FES
Verbal and Numeric Reasoning (VNR) 1.18 1 0 0.0 0.00 1.0e+00 FCHO1
Breast Cancer 2.56 3 0 0.0 0.00 1.0e+00 CDKN2B CDKN2B-AS1 FES
Coronary Artery Disease (CAD) 27.64 6 5 15.2 -0.98 6.4e-04 ADAMTS7 CDKN2B CDKN2B-AS1 PSRC1 RP1-257A7.5 SLC22A3
HDL Cholesterol 1.87 1 0 0.0 0.00 1.0e+00 PSRC1
LDL Cholesterol 51.43 2 1 3.0 0.00 1.0e+00 NUDCD3 PSRC1
Schizophrenia 2.39 1 1 3.0 0.00 1.0e+00 FES
Type 2 Diabetes (T2D) 2.91 1 0 0.0 0.00 1.0e+00 CDKN2B
Blood Platelet Count 1.06 5 2 6.1 -0.16 8.0e-01 ADAMTS7 CDKN2B FCHO1 NUDCD3 SLC22A3
Blood Red Count 0.61 2 0 0.0 0.00 1.0e+00 FES RP1-257A7.5
Blood White Count 1.46 3 1 3.0 0.00 1.0e+00 CDKN2B FCHO1 FES
Heel T-Score 0.52 2 0 0.0 0.00 1.0e+00 FCHO1 PSRC1
BMI 0.93 1 0 0.0 0.00 1.0e+00 SLC22A3
Height 0.76 5 2 6.1 0.74 1.5e-01 FCHO1 FES NUDCD3 PSRC1 SLC22A3
Waist Hip Ratio (WHR) 2.55 3 1 3.0 0.00 1.0e+00 ADAMTS7 FCHO1 SLC22A3
Systolic Blood Pressure 6.83 4 3 9.1 -0.58 4.2e-01 CDH13 FES RP1-257A7.5 SLC22A3
Smoking Status 1.80 1 0 0.0 0.00 1.0e+00 FES
Allergy or Eczema 1.69 1 0 0.0 0.00 1.0e+00 FES
Cardiovascular Disease 7.86 3 2 6.1 0.00 1.0e+00 FES PSRC1 SLC22A3
Respiratory disease 1.68 1 0 0.0 0.00 1.0e+00 FES
Type 2 Diabetes (T2D) 1.56 1 0 0.0 0.00 1.0e+00 SLC22A3
Lung FEV1/FVC ratio 1.45 2 2 6.1 0.00 1.0e+00 PSRC1 RP11-378J18.8
Lung FVC 0.83 2 0 0.0 0.00 1.0e+00 NUDCD3 RP11-378J18.8
Neuroticism 1.32 1 0 0.0 0.00 1.0e+00 NUDCD3
Hair Pigment 0.49 4 3 9.1 0.83 1.7e-01 ADAMTS7 CDKN2B CDKN2B-AS1 FES
Hand grip strength (left) 1.79 1 1 3.0 0.00 1.0e+00 RP1-257A7.5
Number of treatments/medications taken 3.48 2 1 3.0 0.00 1.0e+00 FES PSRC1
Sensitivity / hurt feelings 1.49 1 0 0.0 0.00 1.0e+00 FES
Hearing difficulty/problems: Yes 1.77 1 0 0.0 0.00 1.0e+00 PSRC1
Systolic blood pressure, automated reading 4.83 3 1 3.0 0.00 1.0e+00 CDH13 FES RP1-257A7.5
Angina 25.86 8 7 21.2 0.99 3.0e-06 ADAMTS7 CDKN2B CDKN2B-AS1 FES PSRC1 RP11-378J18.8 RP1-257A7.5 SLC22A3
Medication: Metformin 1.79 1 0 0.0 0.00 1.0e+00 CDKN2B
Pack years adult smoking proportion 3.44 2 1 3.0 0.00 1.0e+00 ADAMTS7 NUDCD3
Impedance of leg (right) 1.39 2 0 0.0 0.00 1.0e+00 FES RP11-378J18.8
Leg fat-free mass (left) 1.26 3 0 0.0 0.00 1.0e+00 NUDCD3 PSRC1 SLC22A3
Trunk fat percentage 1.54 2 0 0.0 0.00 1.0e+00 NUDCD3 SLC22A3
Hand grip strength (right) 1.28 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Current tobacco smoking 2.04 1 0 0.0 0.00 1.0e+00 NUDCD3
High blood pressure 5.32 1 1 3.0 0.00 1.0e+00 FES
Hayfever, allergic rhinitis or eczema 1.58 1 0 0.0 0.00 1.0e+00 FES
Medication: Atenolol 6.24 3 1 3.0 0.00 1.0e+00 CDKN2B FES PSRC1
Sitting height 0.75 2 0 0.0 0.00 1.0e+00 FES SLC22A3
Chronic bronchitis/emphysema (father) 3.07 1 0 0.0 0.00 1.0e+00 ADAMTS7
High blood pressure (mother) 6.27 2 1 3.0 0.00 1.0e+00 FES RP1-257A7.5
Impedance of leg (left) 1.20 2 0 0.0 0.00 1.0e+00 FES RP11-378J18.8
Leg predicted mass (left) 1.28 3 0 0.0 0.00 1.0e+00 NUDCD3 PSRC1 SLC22A3
Trunk fat mass 1.51 2 0 0.0 0.00 1.0e+00 NUDCD3 SLC22A3
Waist circumference 0.87 1 0 0.0 0.00 1.0e+00 NUDCD3
Number of incorrect matches in round 1.62 1 0 0.0 0.00 1.0e+00 FES
Past tobacco smoking 1.80 1 0 0.0 0.00 1.0e+00 CDKN2B-AS1
Alcohol usually taken with meals 1.84 1 0 0.0 0.00 1.0e+00 FES
Had other major operations 2.05 1 0 0.0 0.00 1.0e+00 NUDCD3
Qualifications: None of the above 0.94 1 0 0.0 0.00 1.0e+00 FCHO1
Heart attack 23.42 8 6 18.2 0.99 6.7e-06 CDKN2B CDKN2B-AS1 FCHO1 FES PSRC1 RP11-378J18.8 RP1-257A7.5 SLC22A3
Allergy 1.87 2 0 0.0 0.00 1.0e+00 FCHO1 FES
Medication: Ramipril 4.03 1 0 0.0 0.00 1.0e+00 FES
Medication: Simvastatin 14.91 5 1 3.0 0.93 2.2e-02 CDKN2B CDKN2B-AS1 FES PSRC1 SLC22A3
Fluid intelligence score 1.15 1 0 0.0 0.00 1.0e+00 FCHO1
Illnesses of siblings 3.33 1 0 0.0 0.00 1.0e+00 FES
Weight 1.22 2 0 0.0 0.00 1.0e+00 NUDCD3 SLC22A3
Impedance of arm (right) 0.87 2 0 0.0 0.00 1.0e+00 CDKN2B RP11-378J18.8
Arm fat percentage (right) 1.36 2 0 0.0 0.00 1.0e+00 NUDCD3 SLC22A3
Trunk fat-free mass 1.18 3 1 3.0 0.00 1.0e+00 FCHO1 PSRC1 SLC22A3
Hip circumference 1.38 3 1 3.0 0.00 1.0e+00 ADAMTS7 NUDCD3 SLC22A3
Father's age at death 6.71 4 0 0.0 -1.00 4.3e-04 CDKN2B CDKN2B-AS1 FES PSRC1
Qualifications: A levels/AS levels or equivalent 1.12 1 0 0.0 0.00 1.0e+00 FCHO1
Medication: Ibuprofen (e.g. Nurofen) 4.49 2 1 3.0 0.00 1.0e+00 RP1-257A7.5 SLC22A3
Medication: Cholesterol lowering 21.27 6 2 6.1 0.88 2.2e-02 CDKN2B CDKN2B-AS1 FES PSRC1 RP11-378J18.8 SLC22A3
Lung cancer (father) 4.58 2 0 0.0 0.00 1.0e+00 ADAMTS7 NUDCD3
Illnesses of mother 4.36 2 1 3.0 0.00 1.0e+00 CDKN2B FES
Pulse wave Arterial Stiffness index 3.88 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Arm fat mass (right) 1.24 2 0 0.0 0.00 1.0e+00 NUDCD3 SLC22A3
Trunk predicted mass 1.16 3 1 3.0 0.00 1.0e+00 FCHO1 PSRC1 SLC22A3
Standing height 0.72 3 1 3.0 0.00 1.0e+00 NUDCD3 PSRC1 SLC22A3
Breastfed as a baby 1.28 1 0 0.0 0.00 1.0e+00 FES
Birth weight of first child 2.46 1 1 3.0 0.00 1.0e+00 FES
Medication: Paracetamol 2.53 1 1 3.0 0.00 1.0e+00 RP1-257A7.5
Headache pain in last month 5.03 1 1 3.0 0.00 1.0e+00 RP1-257A7.5
Medication for cholesterol, blood pressure or diabetes 9.71 2 2 6.1 0.00 1.0e+00 FES PSRC1
Glaucoma (self-reported) 6.26 2 1 3.0 0.00 1.0e+00 CDKN2B CDKN2B-AS1
Medication: Amlodipine 2.67 1 1 3.0 0.00 1.0e+00 FES
Medication: Ventolin 100micrograms inhaler 1.60 1 0 0.0 0.00 1.0e+00 FCHO1
Birth weight 2.07 1 0 0.0 0.00 1.0e+00 FES
High blood pressure (siblings) 2.88 1 1 3.0 0.00 1.0e+00 FES
Body fat percentage 1.48 2 0 0.0 0.00 1.0e+00 NUDCD3 SLC22A3
Leg fat percentage (right) 1.21 1 0 0.0 0.00 1.0e+00 RP11-378J18.8
Arm fat-free mass (right) 1.06 2 0 0.0 0.00 1.0e+00 PSRC1 SLC22A3
Pulse wave peak to peak time 3.73 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Medication for pain relief, constipation, heartburn 2.30 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Medication: Blood pressure 5.08 1 1 3.0 0.00 1.0e+00 FES
Angina (self-reported) 26.59 7 7 21.2 0.99 6.9e-06 ADAMTS7 CDKN2B CDKN2B-AS1 FES PSRC1 RP1-257A7.5 SLC22A3
Migraine (self-reported) 5.05 1 1 3.0 0.00 1.0e+00 RP1-257A7.5
Medication: Ibuprofen 4.47 2 1 3.0 0.00 1.0e+00 RP1-257A7.5 SLC22A3
Heart disease (mother) 12.01 5 2 6.1 0.98 4.6e-03 ADAMTS7 CDKN2B CDKN2B-AS1 RP1-257A7.5 SLC22A3
Whole body fat mass 1.50 2 0 0.0 0.00 1.0e+00 NUDCD3 SLC22A3
Leg fat mass (right) 1.11 2 0 0.0 0.00 1.0e+00 NUDCD3 SLC22A3
Arm predicted mass (right) 1.08 2 0 0.0 0.00 1.0e+00 PSRC1 SLC22A3
Pulse rate, automated reading 1.57 2 0 0.0 0.00 1.0e+00 RP11-378J18.8 RP1-257A7.5
Alcohol intake frequency. 1.86 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Comparative height size at age 10 0.81 2 0 0.0 0.00 1.0e+00 PSRC1 SLC22A3
Chest pain or discomfort 2.53 1 0 0.0 0.00 1.0e+00 CDKN2B
Medication: Aspirin 13.98 5 5 15.2 1.00 2.8e-04 CDKN2B CDKN2B-AS1 FES PSRC1 SLC22A3
Hypertension (Self-reported) 5.55 2 1 3.0 0.00 1.0e+00 FES SLC22A3
Smoking status: Previous 1.72 1 0 0.0 0.00 1.0e+00 CDKN2B-AS1
Whole body fat-free mass 1.20 3 0 0.0 0.00 1.0e+00 FCHO1 PSRC1 SLC22A3
Leg fat-free mass (right) 1.36 4 0 0.0 -0.61 3.9e-01 FCHO1 NUDCD3 PSRC1 SLC22A3
Arm fat percentage (left) 1.33 1 0 0.0 0.00 1.0e+00 NUDCD3
Long-standing illness, disability or infirmity 1.55 1 0 0.0 0.00 1.0e+00 CDKN2B
Diabetes diagnosed by doctor 1.32 1 0 0.0 0.00 1.0e+00 SLC22A3
Medication for cholesterol 5.84 3 2 6.1 0.00 1.0e+00 FES PSRC1 SLC22A3
Mineral and other dietary supplements 2.54 1 0 0.0 0.00 1.0e+00 NUDCD3
Breast cancer (self-reported) 2.81 1 0 0.0 0.00 1.0e+00 CDKN2B
Medication: Aspirin 13.78 5 5 15.2 1.00 2.3e-04 CDKN2B CDKN2B-AS1 FES PSRC1 SLC22A3
Illnesses of father: None of the above (group 1) 11.22 5 2 6.1 -0.99 1.2e-03 CDKN2B CDKN2B-AS1 FCHO1 FES SLC22A3
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.09 2 0 0.0 0.00 1.0e+00 ADAMTS7 NUDCD3
Whole body water mass 1.18 3 0 0.0 0.00 1.0e+00 FCHO1 PSRC1 SLC22A3
Leg predicted mass (right) 1.37 4 0 0.0 -0.62 3.8e-01 FCHO1 NUDCD3 PSRC1 SLC22A3
Arm fat mass (left) 1.25 2 0 0.0 0.00 1.0e+00 NUDCD3 SLC22A3
Number of self-reported non-cancer illnesses 2.80 1 0 0.0 0.00 1.0e+00 NUDCD3
Eye problems/disorders: Glaucoma 8.09 2 2 6.1 0.00 1.0e+00 CDKN2B CDKN2B-AS1
Medication: Blood pressure 5.08 3 1 3.0 0.00 1.0e+00 ADAMTS7 FES SLC22A3
Supplements: Fish oil (including cod liver oil) 2.61 2 0 0.0 0.00 1.0e+00 NUDCD3 SLC22A3
High cholesterol (Self-reported) 23.26 4 2 6.1 0.87 1.3e-01 NUDCD3 PSRC1 RP11-378J18.8 SLC22A3
Medication: Bendroflumethiazide 3.51 2 0 0.0 0.00 1.0e+00 ADAMTS7 FES
Medication: Paracetamol 2.19 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Medication: Lisinopril 2.21 1 0 0.0 0.00 1.0e+00 FES
Medication: Atorvastatin 15.33 4 2 6.1 0.99 7.6e-03 CDKN2B CDKN2B-AS1 PSRC1 SLC22A3
Illnesses of father: High blood pressure 4.52 1 1 3.0 0.00 1.0e+00 FES
Ever smoked 1.47 1 0 0.0 0.00 1.0e+00 FES
Basal metabolic rate 1.19 2 0 0.0 0.00 1.0e+00 PSRC1 SLC22A3
Arm fat-free mass (left) 0.99 2 0 0.0 0.00 1.0e+00 PSRC1 SLC22A3
Number of operations (self-reported) 2.05 1 0 0.0 0.00 1.0e+00 NUDCD3
Diastolic blood pressure, automated reading 7.40 5 3 9.1 0.96 1.1e-02 ADAMTS7 CDH13 CDKN2B CDKN2B-AS1 FES
Vascular/heart problems diagnosed by doctor 6.30 3 1 3.0 0.00 1.0e+00 CDKN2B FES SLC22A3
Cholesterol lowering medication 12.84 3 2 6.1 0.00 1.0e+00 CDKN2B PSRC1 SLC22A3
Pain experienced in last month 1.67 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Basal cell carcinoma (self-reported) 2.95 1 0 0.0 0.00 1.0e+00 CDKN2B
Heart attack/myocardial infarction (self-reported) 23.97 8 6 18.2 0.99 7.4e-06 CDKN2B CDKN2B-AS1 FCHO1 FES PSRC1 RP11-378J18.8 RP1-257A7.5 SLC22A3
Heart disease (siblings) 11.30 7 1 3.0 0.98 7.2e-05 ADAMTS7 CDKN2B-AS1 FES PSRC1 RP11-378J18.8 RP1-257A7.5 SLC22A3
Pack years of smoking 3.28 1 1 3.0 0.00 1.0e+00 ADAMTS7
Impedance of whole body 0.82 1 0 0.0 0.00 1.0e+00 RP11-378J18.8
Leg fat mass (left) 1.05 2 0 0.0 0.00 1.0e+00 NUDCD3 SLC22A3
Arm predicted mass (left) 1.08 2 0 0.0 0.00 1.0e+00 PSRC1 SLC22A3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.42
GTEx Adipose Visceral Omentum 1 0.0491 1.41
GTEx Adrenal Gland 0 0.0000 1.30
GTEx Artery Aorta 3 0.1008 1.46
GTEx Artery Coronary 1 0.0845 1.46
GTEx Artery Tibial 2 0.0532 1.47
GTEx Brain Caudate basal ganglia 1 0.1087 1.42
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.39
GTEx Brain Cerebellum 0 0.0000 1.38
GTEx Brain Cortex 0 0.0000 1.45
GTEx Brain Frontal Cortex BA9 1 0.1082 1.46
GTEx Brain Hippocampus 0 0.0000 1.40
GTEx Brain Hypothalamus 1 0.1695 1.43
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.41
GTEx Brain Putamen basal ganglia 0 0.0000 1.42
GTEx Breast Mammary Tissue 0 0.0000 1.38
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.36
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.36
GTEx Cells EBV-transformed lymphocytes 1 0.0703 1.41
GTEx Cells Transformed fibroblasts 2 0.0476 1.40
GTEx Colon Sigmoid 1 0.0684 1.43
GTEx Colon Transverse 0 0.0000 1.35
GTEx Esophagus Gastroesophageal Junction 2 0.1384 1.46
GTEx Esophagus Mucosa 1 0.0301 1.40
GTEx Esophagus Muscularis 1 0.0309 1.39
GTEx Heart Atrial Appendage 0 0.0000 1.33
GTEx Heart Left Ventricle 0 0.0000 1.37
GTEx Liver 1 0.1395 1.49
GTEx Lung 2 0.0696 1.39
GTEx Muscle Skeletal 2 0.0692 1.45
GTEx Nerve Tibial 1 0.0231 1.38
GTEx Ovary 0 0.0000 1.52
GTEx Pancreas 0 0.0000 1.37
GTEx Pituitary 1 0.0897 1.36
GTEx Prostate 0 0.0000 1.34
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.42
GTEx Skin Sun Exposed Lower leg 3 0.0824 1.41
GTEx Small Intestine Terminal Ileum 0 0.0000 1.33
GTEx Spleen 0 0.0000 1.25
GTEx Stomach 0 0.0000 1.31
GTEx Testis 0 0.0000 1.31
GTEx Thyroid 1 0.0250 1.40
GTEx Uterus 0 0.0000 1.48
GTEx Vagina 0 0.0000 1.32
GTEx Whole Blood 3 0.1505 1.39
METSIM Adipose 2 0.0434 1.38
NTR Blood 0 0.0000 1.38
ROSMAP Brain Pre-frontal Cortex 3 0.0683 1.39
YFS Blood 2 0.0433 1.40
CommonMind Brain Pre-frontal Cortex 4 0.0744 1.41
TCGA Breast Tumor 0 0.0000 1.44
TCGA Breast Normal 1 0.0238 1.29
TCGA Ovarian Tumor 2 0.0684 1.28
TCGA Prostate Tumor 1 0.0289 1.30