TWAS hub - CDH13

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1000	0.0350	6.1e-03	-0.002	0.019	0.013	0.013	0.001	8.5e-01	0.0018	9.5e-03	0.0086	2.3e-01
2	GTEx	Artery Aorta	0.3170	0.0780	2.0e-04	0.227	NA	0.263	NA	0.222	1.0e-12	NA	9.1e-15	NA	1.9e-12
3	GTEx	Artery Tibial	0.5058	0.0701	1.0e-08	0.133	NA	0.126	NA	0.101	1.4e-10	NA	4.5e-10	NA	2.4e-08
4	GTEx	Colon Transverse	0.4170	0.0990	5.3e-04	-0.006	NA	-0.004	NA	0.004	8.4e-01	NA	5.5e-01	NA	2.0e-01
5	GTEx	Heart Left Ventricle	0.2821	0.0849	4.7e-03	0.214	NA	0.096	NA	0.186	1.2e-11	NA	8.1e-06	NA	3.4e-10
6	TCGA	Breast Invasive Carcinoma	0.0426	0.0172	7.2e-03	0.023	0.002	-0.001	NA	0.004	1.0e-05	0.1200	5.3e-01	NA	3.5e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Illnesses of father: Heart disease	8.4	11.7	30.9	-0.2	5.6	2.9	3.1	1.4	4.4
Diastolic blood pressure, automated reading	4.2	13.1	46.2	0.8	-6.8	-3.6	-0.9	-1.5	-3.9
Medication: Aspirin	3.4	4.5	10.1	0.4	3.2	1.0	2.2	1.4	3.0
Heart attack/myocardial infarction (self-reported)	3.4	4.4	13.5	0.2	3.1	1.3	1.3	0.6	3.7
Heart attack	3.3	4.3	13.5	0.7	2.9	1.0	1.4	0.6	3.7
Neuroticism score	3.2	6.7	15.2	-2.3	-2.8	-1.3	-0.6	-3.9	-3.0
Bipolar Disorder (2011)	3.1	3.0	11.0	-3.3	1.7	-0.1	0.8	0.4	1.8
Body Mass Index (BMI) (2010)	3.1	4.2	13.1	0.1	3.0	1.5	-0.8	0.4	3.6
Nervous feelings	3.1	5.7	9.8	-1.8	-2.9	-2.0	-1.0	-2.7	-3.1
Systolic Blood Pressure	2.9	14.4	39.4	-2.6	6.3	5.0	1.3	-0.0	3.8
Neuroticism (Nagel 2018)	2.8	6.6	14.3	-1.4	-3.1	-1.9	-0.1	-3.8	-3.2
Medication: Aspirin	2.7	3.5	7.3	0.5	2.5	0.5	2.0	1.6	2.7
Medication: Paracetamol	2.7	4.1	8.1	-1.1	-2.2	-2.0	2.8	1.1	-2.3
Medication: Ibuprofen	2.6	3.1	7.6	-1.1	-2.8	-1.6	1.0	0.3	-2.4
Medication: Seretide 50 evohaler	2.6	3.0	11.5	0.5	1.4	0.6	-1.9	0.7	3.4
Major Depression (MDD)	2.5	3.1	8.1	-2.3	-1.9	-2.8	-0.6	-1.1	0.2
Neuroticism	2.5	6.1	15.6	-2.6	-2.2	-1.8	0.5	-3.9	-2.4
Worrier / anxious feelings	2.5	4.7	10.3	-1.4	-2.7	-0.5	-0.1	-2.9	-3.2
Frequency of tiredness / lethargy in last 2 weeks	2.5	4.0	5.6	-1.4	-2.0	-1.2	2.4	-2.4	-2.4
Bipolar Disorder (2018)	2.4	3.8	21.9	-4.7	0.2	0.5	0.5	0.1	-0.2
Coronary Artery Disease (CAD)	2.4	2.8	9.1	-0.1	2.3	1.4	0.9	-0.1	3.0
Other serious medical condition/disability diagnosed by doctor	2.4	3.1	14.8	0.3	1.2	0.5	3.8	0.2	1.4
Worry (Nagel 2018)	2.3	4.8	10.9	-1.0	-2.7	-1.0	-0.7	-3.3	-2.8
Sensitivity / hurt feelings	2.3	3.9	12.1	-2.4	-1.8	-0.3	0.4	-3.5	-1.5
Father’s age at death	2.3	3.1	6.2	-0.6	-2.5	-2.1	-0.5	-2.2	-1.5
Guilty feelings	2.3	3.5	6.0	-1.9	-1.6	-1.8	-1.0	-2.4	-2.2
Unable to work because of sickness or disability	2.3	3.0	6.5	-1.1	2.5	1.7	0.1	1.8	2.0
Mouth/teeth dental problems	2.2	3.4	6.8	-1.9	2.1	2.2	-0.3	2.6	1.0
Medication: Ibuprofen (e.g. Nurofen)	2.2	2.8	6.6	-0.4	-2.6	-1.8	0.9	0.9	-2.2
Pulse wave reflection index	2.2	2.7	6.2	2.5	-1.7	-2.5	-0.1	-1.0	0.1
Medication: Paracetamol	2.2	3.7	8.1	-1.0	-1.7	-2.4	2.8	0.6	-2.0
Neck or shoulder pain in last month	2.2	3.1	6.6	0.6	-2.1	-2.5	-0.3	-1.2	-2.6
Heart disease (siblings)	2.1	2.5	5.7	-0.6	1.8	1.8	0.9	2.4	1.5
Systolic blood pressure, automated reading	2.0	5.7	15.9	-0.3	4.0	2.9	-1.2	-0.1	2.9
Hayfever, allergic rhinitis or eczema	2.0	4.3	10.0	-1.0	2.1	3.1	3.2	0.4	0.9
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.0	6.1	-0.1	-2.3	-1.9	-0.1	-1.8	-2.5
Medication: Ramipril	2.0	2.6	8.9	0.8	0.7	0.1	3.0	1.5	1.8
Mouth/teeth dental problems: Dentures	2.0	3.3	12.6	0.5	-1.5	-3.5	-1.4	-1.8	0.1
Worry too long after embarrassment	1.9	3.1	6.5	-0.4	-2.2	-1.8	0.0	-2.6	-2.0
Illnesses of father: None of the above (group 1)	1.9	2.3	5.9	-0.5	-2.1	-1.0	-2.4	-1.3	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	7.9	0.5	0.8	-0.2	2.8	1.9	-0.0
Number of operations (self-reported)	1.8	2.7	10.5	0.4	-1.5	-1.3	3.2	-1.2	0.1
Pain experienced in last month	1.8	3.1	6.9	1.2	2.2	2.6	-0.5	1.0	1.9
Tense / ‘highly strung’	1.7	2.8	7.3	0.0	-2.2	-0.2	0.2	-2.7	-2.1
Ever had bowel cancer screening	1.7	2.0	4.2	-0.5	-1.3	-1.7	1.6	-2.0	0.1
Back pain experienced in last month	1.7	2.5	9.2	1.0	-1.6	-3.0	0.6	-1.0	-1.0
Miserableness	1.7	3.0	5.9	-1.4	-2.2	-1.5	-1.2	-2.4	-1.3
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	4.8	-0.9	1.5	1.4	1.1	-0.2	2.2
Ever highly irritable/argumentative for 2 days	1.6	2.0	3.7	-1.9	-0.7	-1.2	-1.6	-1.9	-0.4
Number of full brothers	1.6	2.1	6.4	-0.4	-1.9	-0.9	-0.3	-1.1	-2.5
Mouth/teeth dental problems: Loose teeth	1.6	2.0	5.4	1.2	-2.3	-1.5	1.3	-0.5	-0.7
Osteoarthritis (self-reported)	1.6	2.1	8.8	0.2	-1.7	-3.0	0.2	-0.5	-0.6
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	3.3	1.7	-0.7	-1.3	1.0	-0.8	-1.8
Angina	1.5	2.0	5.7	0.0	2.4	1.5	1.4	0.3	1.3
Maternal smoking around birth	1.5	2.2	5.9	2.4	0.7	-1.7	0.1	0.7	1.9
Serious illness, injury or assault to yourself	1.5	1.8	3.7	0.6	1.9	1.4	1.7	0.3	1.3
Medication: Atenolol	1.5	1.8	3.7	-1.2	-1.1	-0.5	1.9	-1.9	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.4	4.4	-1.9	-2.1	-2.0	-0.5	-0.4	-1.3
Pulse wave peak to peak time	1.5	1.8	4.7	-0.9	1.2	2.2	0.5	1.4	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	6.4	-0.6	-2.5	-1.4	0.8	-1.1	-0.4
Risk taking	1.5	2.2	7.9	2.8	1.1	-1.5	1.1	0.6	0.4
Number of treatments/medications taken	1.4	2.5	7.8	-1.6	-1.1	-1.9	2.8	-0.0	0.3
Vitamin and mineral supplements	1.4	1.9	5.2	-1.0	2.3	1.9	0.9	0.4	0.9
Average weekly fortified wine intake	1.4	1.6	3.8	-1.2	-1.4	-0.5	1.0	-1.1	-2.0
High blood pressure (mother)	1.4	2.0	4.6	0.5	1.8	1.6	2.1	-0.2	1.0
Alcohol usually taken with meals	1.4	2.2	6.2	-0.9	-0.5	1.1	-0.1	-2.5	-2.1
Pain all over the body in last month	1.4	1.5	2.8	-1.5	0.5	1.5	1.7	1.1	0.4
Medication: Cholesterol lowering	1.4	2.2	6.5	-1.2	1.0	-0.3	2.5	-1.0	1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	4.6	-1.6	2.1	0.3	0.6	0.2	1.4
Angina (self-reported)	1.4	1.8	5.3	-0.2	2.3	1.3	1.3	-0.1	1.5
Medication: Atorvastatin	1.4	1.7	2.8	-0.1	1.7	-0.8	1.6	1.6	1.3
Fasting Glucose	1.3	1.6	3.8	-1.7	-0.5	-0.3	-1.4	-0.8	1.9
Multivitamins +/- minerals	1.3	1.7	3.6	1.6	-1.9	-1.6	-0.9	-0.5	-0.5
Diverticular disease/diverticulitis (self-reported)	1.3	1.6	3.9	-1.2	1.6	1.2	-0.3	-2.0	0.6
Hair/balding pattern: Pattern 2	1.3	1.7	4.8	-1.1	0.8	-1.2	2.2	-0.4	1.3
Pulse wave Arterial Stiffness index	1.3	1.5	3.4	1.3	-1.1	-1.8	-0.2	-1.4	1.0
Headache pain in last month	1.3	2.3	5.4	-0.3	-2.3	-1.4	0.9	0.1	-2.3
Chronic bronchitis/emphysema (mother)	1.3	1.5	5.0	2.2	-0.9	-1.4	0.3	-0.7	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	4.2	-0.7	-2.0	-0.5	0.8	0.7	-2.0
Family relationship satisfaction	1.3	1.6	4.8	-0.4	-1.2	-2.2	-0.4	-0.4	-1.6
Commuting to job workplace: Walk	1.3	1.4	5.6	2.4	0.5	-0.6	0.7	0.5	-1.2
Commuting to job workplace: Public transport	1.3	1.6	3.9	2.0	-0.7	0.7	0.3	-0.9	-2.0
Depressed Affect (Nagel 2018)	1.2	2.5	4.2	-1.9	-1.5	-1.1	0.3	-2.1	-1.8
Reaction Time	1.2	2.3	4.7	-1.6	-1.3	-1.6	0.9	1.2	-2.2
Average weekly spirits intake	1.2	1.5	3.8	2.0	-1.1	-0.2	1.6	-1.1	0.5
Ever had hysterectomy (womb removed)	1.2	1.4	4.0	-0.7	-0.7	-2.0	1.3	-1.0	-0.6
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	6.3	1.0	-1.1	-1.0	-2.5	0.6	-1.5
Shortness of breath walking on level ground	1.2	1.5	3.4	1.5	-1.2	-1.1	-0.3	-1.9	-0.6
Mean time to correctly identify matches	1.2	2.2	4.9	-2.2	-1.3	-1.7	0.2	1.3	-1.5
Alzheimer’s Disease (including proxy)	1.1	1.6	6.0	0.3	-1.5	-2.5	-0.2	0.8	-0.5
Ever used hormone-replacement therapy (HRT)	1.1	1.4	5.1	-0.2	-0.4	-2.2	1.5	-0.8	-0.7
Had other major operations	1.1	1.3	3.7	-0.2	-1.2	-1.1	1.9	-1.3	-0.2
Allergy	1.1	2.6	6.3	0.9	-1.6	-2.5	-2.3	-0.5	-0.7
Depression (self-reported)	1.1	1.3	2.7	-1.4	-1.1	-1.6	1.1	-0.4	-0.5
Birth weight	1.1	2.4	6.5	2.1	-0.9	1.2	0.0	-0.8	-2.6
Medication for pain relief, constipation, heartburn	1.1	1.9	6.6	1.0	0.3	1.7	-2.6	-0.8	0.4
Medication: Blood pressure	1.1	2.0	8.1	-0.8	1.2	1.2	2.9	-0.1	0.7
Wears glasses or contact lenses	1.1	1.3	2.6	-1.6	-0.6	-1.4	-0.5	-0.9	1.3
Hearing aid user	1.1	1.2	3.3	0.7	0.7	0.2	1.8	1.5	0.9
Pain type(s) experienced in last month: Hip pain	1.1	1.4	5.2	1.3	-0.2	-2.3	1.3	-0.1	-0.2
Bipolar Disorder or Schizophrenia	1.0	2.5	12.5	-3.5	0.1	0.1	-0.6	1.5	-0.4
Schizophrenia vs Biploar Disorder	1.0	1.3	5.5	2.3	0.3	0.0	-1.3	0.9	-0.1
Mean Putamen Volume	1.0	1.2	3.5	-0.4	-1.9	-1.1	0.1	-1.0	-1.1
Neuroticism (2016)	1.0	1.5	3.7	-0.5	-1.9	-1.0	-0.5	-0.8	-1.8
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.8	-1.4	-1.7	0.4	-1.0	-1.1	-0.1
Medication: Co-codamol	1.0	1.1	3.3	1.8	-0.5	-0.7	0.6	-1.0	1.1
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	3.0	-0.5	0.6	0.1	1.7	0.2	1.6
Chronic bronchitis/emphysema (father)	1.0	1.2	5.7	0.7	-0.8	-2.4	-0.5	0.2	-0.4
Lung cancer (father)	1.0	1.1	2.4	0.9	-1.3	-0.6	-1.1	-0.6	1.5
Blood clot in the leg (DVT)	1.0	1.3	4.8	0.3	-0.5	0.5	2.2	1.0	-1.3
Eye problems/disorders: None of the above	1.0	1.2	2.7	0.5	-0.4	1.0	-0.7	1.6	-1.6
Medication: Allopurinol	1.0	1.3	3.3	-1.8	0.9	1.5	-0.7	0.6	0.8
Heart disease (mother)	1.0	1.2	2.8	-1.0	1.7	1.1	1.2	0.0	1.1
Suffer from ‘nerves’	1.0	1.5	4.7	-0.8	-0.5	0.2	-0.5	-2.2	-1.8
Chest pain or discomfort	1.0	1.4	4.9	-0.8	0.9	2.2	1.2	0.1	0.8
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.8	-0.9	-1.4	-1.0	-1.7	-0.2	-0.9
Medication: Bendroflumethiazide	1.0	1.5	3.3	-0.7	1.4	1.1	1.8	-1.2	0.6
Ever smoked	1.0	1.8	8.1	2.8	-0.0	-0.9	0.3	-1.1	-0.6
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	5.4	0.0	-0.2	0.5	2.3	0.9	-0.9
Ovarian Cancer	0.9	1.2	4.0	-0.5	-1.6	-0.4	0.6	-0.2	-2.0
HDL Cholesterol	0.9	1.6	4.5	0.7	1.7	2.1	1.1	-0.2	0.4
Hearing difficulty/problems: Yes	0.9	1.3	2.7	0.3	-1.6	-1.1	0.7	-1.6	-0.9
Diabetes (mother)	0.9	1.1	4.1	-2.0	-0.6	0.2	0.0	-1.1	0.8
Severe depression (siblings)	0.9	1.0	3.6	0.6	-0.2	0.4	-1.0	1.9	-0.8
Hand grip strength (right)	0.9	2.3	7.9	1.9	1.4	2.8	0.1	0.7	0.1
Stomach or abdominal pain in last month	0.9	1.2	4.3	2.1	-0.4	0.2	0.5	-0.1	-1.5
Past tobacco smoking	0.9	1.6	6.0	-2.4	-0.7	-0.1	0.2	1.7	-0.6
Medication: Simvastatin	0.9	1.3	4.1	-1.0	0.5	0.4	-0.0	-2.0	1.5
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	4.0	-0.1	0.7	2.0	0.8	-1.5	-0.2
High blood pressure (siblings)	0.9	1.3	5.4	0.4	-0.6	0.8	-0.0	-2.3	-1.0
Wheeze or whistling in the chest in last year	0.9	1.5	5.6	0.1	-1.6	-0.7	-2.4	-0.6	0.3
Emphysema/chronic bronchitis	0.9	1.0	4.4	-0.8	0.2	-0.1	-2.1	-0.7	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	3.0	0.7	0.0	-0.6	-1.5	1.7	0.4
Pulse rate, automated reading	0.9	2.9	8.7	-1.3	1.7	0.8	-0.1	2.9	1.8
Commuting to job workplace: Car/motor vehicle	0.9	1.0	4.6	-0.7	0.3	-0.3	0.7	0.6	2.1
Smoking status: Previous	0.9	1.3	3.3	1.8	-0.1	0.1	-1.1	-1.7	0.5
Long-standing illness, disability or infirmity	0.9	1.3	3.3	-0.2	-0.2	-0.6	1.7	-1.8	1.2
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	3.1	1.0	-0.8	-1.0	1.8	-1.3	-1.1
Irritability	0.9	1.6	7.9	-0.6	-0.5	-0.0	0.2	-2.8	-1.0
Alcohol drinker status: Previous	0.9	1.1	5.0	0.0	-0.9	0.1	0.3	0.7	-2.2
Alzheimer’s Disease (in mother)	0.8	1.0	3.7	0.3	-0.5	-1.9	-0.9	1.0	-0.6
Crohns Disease (2017)	0.8	1.8	4.0	-2.0	1.9	1.3	0.3	0.7	0.8
Cardiovascular Disease	0.8	2.5	4.7	-2.2	0.8	0.7	1.5	-2.2	1.5
Chronotype (morning person)	0.8	1.9	5.1	-2.3	-0.4	-1.6	-1.1	1.1	1.1
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.9	0.1	-1.1	-1.4	1.1	-0.7	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	4.1	1.3	0.8	1.8	-0.2	-2.0	-0.7
Number of incorrect matches in round	0.8	1.3	3.1	0.2	-1.6	-1.8	-0.6	0.6	-1.2
Had menopause	0.8	1.1	3.3	0.3	0.2	-1.8	0.9	-1.4	0.1
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.5	-0.4	-1.0	-1.2	-1.2	1.2	-0.3
Qualifications: None of the above	0.8	1.7	5.4	-0.2	-1.9	-2.3	-0.1	-1.0	-0.2
Comparative body size at age 10	0.8	2.2	5.5	-1.0	1.8	2.3	0.4	1.6	0.9
Migraine (self-reported)	0.8	1.0	3.2	-1.8	-0.1	0.5	-1.4	-0.6	-0.6
Had major operations	0.8	1.0	3.9	-0.3	-0.8	-0.8	2.0	-0.7	-0.4
Age at last live birth	0.8	1.2	3.9	0.5	1.6	2.0	-0.2	0.4	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	5.0	1.6	1.1	2.2	0.6	-0.6	-0.1
Average weekly red wine intake	0.8	1.1	2.8	0.9	0.5	1.7	0.6	-1.6	0.0
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.0	1.4	1.1	-0.9	-0.4	1.3	0.3
Eye problems/disorders: Glaucoma	0.8	1.0	2.6	-0.3	1.1	-0.5	0.9	-0.9	1.6
Medication: Lisinopril	0.8	1.0	2.0	-1.3	1.3	0.5	-1.4	-0.6	0.1
Supplements: Calcium	0.8	0.9	2.6	0.5	0.9	1.0	1.6	0.2	0.6
Alzheimer’s Disease (in father)	0.7	0.7	1.9	-0.6	-1.2	-1.4	-0.0	0.3	0.8
LDL Cholesterol	0.7	1.1	3.8	0.1	1.9	-0.5	0.6	0.1	1.5
Primary Biliary Cirrhosis	0.7	1.0	5.0	-0.0	-0.6	-2.2	0.1	0.3	-0.7
Fed-up feelings	0.7	1.2	2.1	-1.2	-1.4	-0.1	-1.0	-1.4	-0.8
Alcohol intake versus 10 years previously	0.7	1.1	2.8	1.7	1.1	0.4	-0.8	0.0	1.4
Noisy workplace	0.7	0.9	1.9	0.7	1.2	0.3	1.1	0.5	1.4
Birth weight of first child	0.7	1.3	3.6	0.2	0.9	0.8	1.0	1.9	1.3
Glaucoma (self-reported)	0.7	0.9	2.2	-0.3	0.9	-0.8	1.0	-0.6	1.5
Medication: Omeprazole	0.7	0.8	2.0	0.7	-0.9	0.9	0.9	-1.4	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.6	-1.1	0.8	-0.5	1.3	-0.0	1.2
Supplements: Vitamin C	0.7	0.8	1.3	1.1	-0.6	-1.0	0.9	0.5	-1.0
Mood swings	0.7	1.3	3.3	-0.3	-0.6	-1.0	-0.3	-1.8	-1.6
Loneliness, isolation	0.7	0.9	2.9	0.2	-1.3	-0.2	0.6	-0.6	-1.7
Breast cancer (self-reported)	0.7	0.8	1.6	1.3	-0.6	-1.0	1.2	-0.2	-0.6
Tinnitus: Yes, now most or all of the time	0.7	0.9	4.0	0.2	-0.1	2.0	0.4	0.5	0.9
Illnesses of father: High blood pressure	0.7	0.8	1.9	0.5	1.1	1.4	1.2	-0.2	0.1
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.7	-0.6	-1.3	-1.2	-0.9	-0.8	0.4
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.8	0.4	-0.7	0.5	1.2	-1.7	-0.3
Basal cell carcinoma (self-reported)	0.7	0.8	2.7	0.5	0.6	1.1	0.5	1.6	-0.2
Depression (Nagel 2018)	0.6	0.8	1.3	0.7	-1.0	-1.1	0.7	-0.8	-1.0
Prostate Cancer	0.6	0.8	2.3	-0.1	-1.5	-0.9	0.7	-1.0	-0.6
Age at First Birth	0.6	0.8	3.0	-0.3	0.0	-0.0	-1.7	-0.8	1.1
Schizophrenia (2014)	0.6	1.3	4.4	-1.4	0.6	0.2	-0.7	2.1	-0.6
Smoking Status	0.6	1.3	4.7	1.2	1.2	-0.5	-0.1	-0.3	2.2
Allergy or Eczema	0.6	1.7	3.8	-1.3	1.2	1.6	1.9	-0.0	0.8
Hand grip strength (left)	0.6	1.7	4.5	1.5	1.4	2.1	-0.2	1.0	-0.6
Diabetes (father)	0.6	0.8	2.8	-0.3	-0.0	1.2	1.7	-0.3	-0.3
Townsend deprivation index at recruitment	0.6	0.8	1.9	-1.4	-1.0	-0.5	-1.1	-0.4	-0.4
Taking other prescription medications	0.6	1.0	4.0	-0.1	-0.7	-1.1	2.0	-0.0	0.1
High blood pressure	0.6	1.6	3.6	-1.7	-0.4	-0.2	1.9	-1.7	-0.5
Hearing difficulty/problems with background noise	0.6	1.0	2.2	-0.5	-1.0	-0.5	-0.2	-1.4	-1.5
Pulse rate	0.6	1.0	3.2	-0.6	0.7	1.0	-0.9	1.8	0.5
Prospective memory result	0.6	0.8	3.1	-0.5	-0.2	-0.7	-0.7	-1.8	0.6
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	3.0	0.8	1.2	1.7	-0.2	-0.1	0.5
Medication: Amlodipine	0.6	0.9	2.7	-0.5	1.0	0.3	1.6	0.2	1.0
Health satisfaction	0.6	0.8	2.7	0.8	0.9	0.6	1.6	0.4	-0.1
Alcohol intake frequency.	0.6	1.3	4.4	0.6	-1.7	0.5	0.2	0.0	-2.1
Number of full sisters	0.6	0.7	1.7	-0.8	1.3	0.3	-1.1	-0.7	0.6
Leg pain on walking	0.6	0.7	1.8	-1.0	0.4	-0.6	1.3	0.9	0.5
Knee pain experienced in last month	0.6	0.9	4.3	0.3	-0.2	0.8	2.1	-0.7	-0.2
Hypertension (Self-reported)	0.6	1.7	3.6	-1.8	-0.4	-0.2	1.9	-1.8	-0.2
Ever taken oral contraceptive pill	0.6	0.7	1.6	-0.0	1.0	0.7	1.3	0.3	1.0
Medication: Blood pressure	0.6	1.1	3.8	-0.5	-0.9	-0.6	1.0	-1.9	-0.6
Commuting to job workplace: Cycle	0.6	0.7	3.6	0.2	0.6	1.9	-0.0	-0.0	-0.3
Pack years of smoking	0.6	0.9	2.3	0.7	-0.1	-0.7	0.3	1.4	-1.5
Verbal and Numeric Reasoning (VNR)	0.5	1.2	4.7	1.4	-0.1	0.4	-0.2	-0.3	-2.2
Breast Cancer	0.5	1.2	4.5	2.1	-1.3	0.5	-0.4	0.5	-0.3
HbA1C	0.5	0.5	1.0	-0.5	-0.8	-1.0	0.4	-0.6	0.8
Medication for hormone replacement therapy	0.5	0.6	2.3	0.3	0.0	0.8	1.5	-0.7	-0.2
Pack years adult smoking proportion	0.5	0.8	3.1	0.5	0.0	-0.2	0.2	1.2	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.7	0.9	-1.2	-0.1	0.0	-0.3	-1.3
Supplements: Glucosamine	0.5	0.6	2.4	-0.4	-0.5	-1.6	0.5	-0.1	-0.8
Waist circumference	0.5	1.9	3.1	-1.0	1.8	1.2	1.4	-0.8	1.8
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	2.3	-1.5	0.1	0.4	1.2	0.6	0.1
Fluid intelligence score	0.5	1.1	4.3	2.1	0.3	0.4	-0.3	-0.4	-1.3
Illnesses of siblings	0.5	0.7	1.7	0.1	0.4	-1.3	0.6	1.1	0.9
Falls in the last year	0.5	0.6	1.4	1.2	-0.8	-0.6	0.5	-0.8	0.7
Number of live births	0.5	0.8	2.9	-0.8	-0.1	-1.7	0.7	0.5	0.6
Qualifications: A levels/AS levels or equivalent	0.5	1.0	3.1	0.3	-0.4	1.8	1.0	0.4	-1.3
Exposure to tobacco smoke at home	0.5	0.6	2.0	-1.1	0.4	-0.5	-1.4	0.2	0.0
Gout (self-reported)	0.5	0.6	1.4	-1.0	-0.4	-1.1	-0.4	1.2	-0.2
Age at first live birth	0.5	0.9	2.7	0.2	0.9	1.7	-1.2	0.1	0.4
Qualifications: College or University degree	0.5	1.6	3.4	1.2	1.2	1.7	-0.4	1.8	-0.7
Leg fat-free mass (right)	0.5	2.8	7.7	1.6	1.8	2.8	1.7	0.0	0.6
Friendships satisfaction	0.5	0.6	1.2	0.9	-0.5	-0.7	0.3	-1.1	-1.0
Medication for cholesterol	0.5	0.8	4.0	0.6	0.4	-0.1	-0.3	2.0	-0.2
Osteoporosis (self-reported)	0.5	0.7	3.4	-0.1	-0.4	0.6	1.9	-0.1	0.1
Medication: Gliclazide	0.5	0.5	1.3	0.7	-0.2	-0.3	-0.9	1.1	0.5
Leg predicted mass (right)	0.5	2.7	7.7	1.5	1.7	2.8	1.6	0.0	0.7
Number of self-reported non-cancer illnesses	0.5	0.8	2.7	-0.4	-1.2	-0.6	1.6	-0.5	0.3
Average weekly beer plus cider intake	0.5	0.8	2.3	-0.5	0.7	0.6	-0.7	0.9	1.5
Myopia	0.5	0.7	2.7	-0.6	-0.4	0.5	-1.6	-0.1	-1.0
Vascular/heart problems diagnosed by doctor	0.5	1.4	4.2	0.9	-0.4	-0.5	-2.1	1.6	-0.6
Cholesterol lowering medication	0.5	0.8	1.5	-1.0	0.5	-0.2	-0.9	-1.0	1.2
Intelligence (Savage-Jansen 2018)	0.4	1.1	3.4	0.9	-0.0	1.0	-0.0	-1.2	-1.8
Schizophrenia (2018)	0.4	0.9	3.1	-0.8	-0.1	-0.2	-1.2	1.8	-0.3
Lupus	0.4	0.5	1.2	0.0	-1.1	-0.2	-0.5	-1.0	-0.9
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.3	0.9	1.1	1.1	1.1	0.5	-0.3
Supplements: Zinc	0.4	0.4	1.3	-0.7	-0.1	-1.1	-0.5	0.4	-0.0
Leg fat-free mass (left)	0.4	2.3	5.6	1.5	1.8	2.4	1.6	0.1	0.7
Trunk fat percentage	0.4	1.5	2.1	-0.9	1.5	1.4	1.4	0.0	1.4
Age when periods started (menarche)	0.4	1.1	2.1	-0.8	-0.6	1.0	1.5	-0.7	-1.3
Sitting height	0.4	2.7	4.8	2.2	1.9	2.0	1.9	0.6	0.1
Leg predicted mass (left)	0.4	2.3	5.5	1.5	1.7	2.3	1.6	0.1	0.7
Trunk fat mass	0.4	1.7	3.1	-0.5	1.6	1.6	1.8	0.0	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	2.7	1.0	0.2	1.6	0.1	-0.8	-0.8
Happiness	0.4	0.5	1.3	0.2	-0.6	-0.6	-0.5	-1.1	-0.8
Medication: Lansoprazole	0.4	0.4	1.2	0.6	-0.4	-0.7	1.1	-0.3	-0.4
Illnesses of mother	0.4	0.5	1.7	-0.1	-1.3	0.2	-0.6	-0.1	-1.1
Standing height	0.4	3.7	12.5	2.4	0.5	1.5	3.5	0.2	-1.3
Breastfed as a baby	0.4	0.5	1.2	-0.9	0.5	0.1	-0.3	-0.7	1.1
Hair/balding pattern: Pattern 4	0.4	0.9	1.9	0.6	-0.6	1.2	-0.6	-1.4	-0.8
Peak expiratory flow (PEF)	0.4	0.8	1.6	1.3	0.3	-1.2	1.1	0.4	0.7
Leg fat percentage (right)	0.4	1.3	3.9	-1.6	0.9	-0.4	0.5	-0.0	2.0
Whole body fat mass	0.4	1.8	3.1	-0.5	1.7	1.8	1.4	-0.1	1.5
Leg fat mass (right)	0.4	1.5	4.4	-0.9	1.6	0.8	0.9	-0.0	2.1
Illnesses of siblings: Diabetes	0.4	0.5	1.3	-0.7	-0.2	0.5	0.7	-1.1	-0.4
Arm fat percentage (left)	0.4	1.6	4.1	-1.1	1.5	2.0	0.4	-0.0	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.2	-0.5	0.4	-0.9	1.1	-0.0	-0.2
Financial situation satisfaction	0.4	0.5	1.5	0.3	0.0	0.8	0.5	-1.2	-0.9
Supplements: Fish oil (including cod liver oil)	0.4	0.5	2.1	-0.4	0.4	-0.7	-1.4	0.2	0.2
High cholesterol (Self-reported)	0.4	0.8	1.8	-0.7	0.0	-0.2	1.3	-1.2	0.8
Alcohol drinker status: Never	0.4	0.5	1.2	-0.9	-1.1	-0.5	0.3	-0.8	-0.2
Leg fat percentage (left)	0.4	1.3	4.2	-1.6	0.8	-0.1	0.6	-0.0	2.1
Fractured/broken bones in last 5 years	0.4	0.5	2.4	0.1	0.2	0.4	-0.2	-0.8	1.5
Age started oral contraceptive pill	0.4	0.5	2.4	-0.3	-0.7	-1.5	0.3	-0.1	0.1
Leg fat mass (left)	0.4	1.7	5.2	-0.7	1.6	0.9	1.0	0.0	2.3
Ulcerative Colitis (UC)	0.3	0.6	1.2	0.7	-0.6	-0.5	1.0	0.5	-1.1
Rheumatoid Arthritis	0.3	0.5	0.9	0.4	-0.7	0.2	-1.0	0.6	0.9
Triglycerides	0.3	0.5	1.2	-0.9	-0.0	-0.8	-0.8	0.1	1.1
BMI	0.3	1.8	5.3	-0.7	2.0	0.9	-0.1	-0.4	2.3
Waist Hip Ratio (WHR)	0.3	1.5	3.9	-0.8	2.0	0.6	1.4	-0.1	1.5
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.3	0.8	-0.4	-0.6	0.2	-0.2	-1.1
Relative age of first facial hair	0.3	0.7	1.8	0.8	0.7	1.0	-0.1	1.3	0.3
Medication: Metformin	0.3	0.4	1.6	0.4	0.1	1.3	0.2	0.8	-0.1
Impedance of leg (right)	0.3	1.4	3.8	-1.3	-1.2	-2.0	0.7	0.2	-0.9
Qualifications: CSEs or equivalent	0.3	0.4	0.7	0.5	0.6	0.6	0.8	0.6	0.5
Medication: Levothyroxine sodium	0.3	0.5	1.8	1.3	0.4	-0.3	-0.1	-0.3	1.0
Body mass index (BMI)	0.3	1.3	3.7	-0.7	1.6	0.9	0.1	-0.4	1.9
Financial difficulties in last 2 years	0.3	0.4	0.9	0.2	-0.6	0.6	-0.9	0.4	-0.9
Weight	0.3	1.7	3.1	0.3	1.7	1.4	1.8	-0.2	1.3
Arm fat percentage (right)	0.3	1.2	3.3	-0.9	1.2	1.8	0.4	-0.3	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.3	-0.2	1.0	1.5	1.5	-0.1	0.4
Arm fat mass (right)	0.3	1.3	2.5	-0.5	1.6	1.6	0.9	-0.2	1.4
Forced vital capacity (FVC), Best measure	0.3	1.2	3.2	0.1	0.5	1.8	1.8	-0.7	-0.2
Body fat percentage	0.3	1.3	2.1	-1.1	1.2	1.1	1.3	-0.0	1.4
Arm predicted mass (right)	0.3	1.4	5.2	1.2	1.1	0.2	2.3	-0.1	0.6
Overall health rating	0.3	0.6	1.1	-0.5	0.0	0.1	1.0	-1.1	1.0
Whole body fat-free mass	0.3	1.7	4.1	1.6	1.1	1.6	2.0	0.0	0.2
Whole body water mass	0.3	1.8	4.1	1.6	1.2	1.5	2.0	0.0	0.3
Arm fat mass (left)	0.3	1.4	2.8	-0.4	1.7	1.6	1.0	-0.1	1.3
Average weekly champagne plus white wine intake	0.3	0.4	1.4	-0.0	0.5	-0.1	1.2	0.3	0.8
Mother’s age at death	0.3	0.4	1.4	-0.0	0.8	-1.2	-0.4	0.2	0.2
Basal metabolic rate	0.3	1.7	3.9	1.3	1.3	1.6	2.0	0.0	0.5
Ever depressed for a whole week	0.3	0.4	1.2	0.7	0.4	0.2	0.4	1.1	-0.5
Irritable Bowel Disease (IBD)	0.2	0.5	0.9	-0.7	0.9	0.6	1.0	0.7	-0.2
Crohns Disease (2012)	0.2	0.4	0.9	-0.1	0.9	0.5	0.3	0.9	0.7
Ulcerative Colitis	0.2	0.3	0.9	0.5	-0.4	-0.1	1.0	0.4	-0.5
Blood Eosinophil Count	0.2	1.2	2.3	-0.3	1.4	1.5	1.1	0.2	1.2
Blood White Count	0.2	1.6	5.7	-1.0	1.4	0.7	-0.5	0.6	2.4
Respiratory disease	0.2	0.4	1.7	-0.2	-0.8	0.2	-1.3	-0.3	0.2
Lung FEV1/FVC ratio	0.2	1.1	3.8	0.3	2.0	-0.5	-0.4	-0.4	1.4
Current tobacco smoking	0.2	0.4	1.0	0.7	-0.6	-1.0	0.5	0.2	-0.2
Relative age voice broke	0.2	0.3	0.9	-0.1	0.9	0.1	0.1	-0.2	0.9
Impedance of leg (left)	0.2	1.2	2.3	-1.3	-1.4	-1.5	0.6	0.4	-0.8
Forced vital capacity (FVC)	0.2	0.6	1.1	0.6	-0.3	1.1	1.0	0.0	-1.0
Diabetes (self-reported)	0.2	0.3	0.5	-0.6	0.1	0.7	0.6	0.2	0.6
Impedance of arm (right)	0.2	1.1	4.2	0.3	-0.5	2.0	0.4	0.4	-1.3
Trunk fat-free mass	0.2	1.4	4.0	1.8	0.6	0.9	2.0	-0.1	-0.1
Time employed in main current job	0.2	0.3	1.3	-0.4	-1.1	-0.3	-0.3	0.3	0.1
Hair/balding pattern: Pattern 3	0.2	0.2	0.8	-0.3	0.2	0.2	-0.9	-0.5	-0.5
Asthma	0.2	0.4	1.1	0.2	-0.0	1.0	0.0	-0.9	0.8
Impedance of arm (left)	0.2	1.0	4.1	-0.2	-0.0	2.0	0.6	0.6	-1.0
Trunk predicted mass	0.2	1.3	4.0	1.7	0.5	0.9	2.0	-0.1	-0.1
Length of working week for main job	0.2	0.2	0.6	0.3	0.8	0.1	0.1	-0.4	0.6
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.7	-0.4	-0.7	-0.4	-0.5	0.8	0.3
Arm fat-free mass (right)	0.2	1.2	3.6	1.1	1.3	0.5	1.9	-0.2	0.7
Exposure to tobacco smoke outside home	0.2	0.3	0.8	0.3	0.6	0.9	-0.1	0.2	0.8
Eye problems/disorders: Cataract	0.2	0.2	0.6	-0.1	-0.7	-0.1	-0.1	-0.8	-0.2
Mineral and other dietary supplements	0.2	0.2	0.9	-0.1	-0.3	1.0	0.4	-0.0	0.4
Arm fat-free mass (left)	0.2	1.2	4.3	1.3	1.0	0.3	2.1	0.0	0.4
Arm predicted mass (left)	0.2	1.2	4.5	1.3	0.8	0.1	2.1	-0.2	0.5
Heel T-Score	0.1	1.1	3.9	0.5	1.4	2.0	-0.5	0.0	-0.1
Height	0.1	2.9	10.8	2.0	-0.6	0.7	3.3	-0.5	-1.2
Lung FVC	0.1	0.4	1.0	-1.0	-0.1	-0.8	0.3	-0.2	0.6
Hip circumference	0.1	0.6	1.1	-0.1	0.6	1.0	1.0	-0.4	1.0
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.1	0.4	0.6	0.9	1.0	0.4	-0.1
Loud music exposure frequency	0.1	0.2	0.3	-0.1	0.5	0.5	0.0	-0.5	-0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	0.6	-0.1	-0.1	-0.7	0.2	0.3
Number of children fathered	0.1	0.1	0.2	0.1	0.1	-0.3	0.4	-0.3	0.4
Comparative height size at age 10	0.1	0.7	2.1	0.9	-0.7	-0.0	1.5	0.6	-0.6
Diabetes diagnosed by doctor	0.1	0.1	0.3	0.1	0.2	0.6	0.3	0.3	0.3
Qualifications: nursing, teaching	0.1	0.1	0.4	0.4	-0.1	0.2	0.5	-0.6	0.2
Asthma (self-reported)	0.1	0.2	0.4	-0.2	-0.3	0.6	-0.1	-0.7	0.7
Smoking status: Current	0.1	0.2	0.5	0.2	0.1	-0.7	0.7	-0.0	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.5	-0.2	0.2	0.5	0.7	-0.5	-0.3
Impedance of whole body	0.1	0.6	1.3	-0.6	-0.7	0.3	1.1	0.6	-1.1
Blood Platelet Count	0.0	0.3	0.7	0.1	-0.4	-0.5	0.5	-0.8	-0.6
Blood Red Count	0.0	0.5	2.1	-1.4	0.0	-0.4	0.1	0.3	-0.7
Hypothyroidism (self reported)	0.0	0.1	0.1	0.4	-0.3	0.1	-0.2	-0.0	0.4
Hair Pigment	0.0	0.8	2.9	0.6	-0.2	0.8	-1.7	0.6	-0.8
Tanning	0.0	0.2	0.6	0.3	0.2	0.3	0.0	-0.4	-0.8

Hub : Genes

CDH13

Models

Trait associations