Hub : Traits :

Pack years adult smoking proportion

65 significantly associated models · 20 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 48381826 49817450 1 1 4.3e-08 8.0e-06 0.9300 100 QRICH1
2 7 73624615 74494207 1 1 2.4e-07 1.3e-07 0.0077 74 AC004166.6
3 10 64531160 65911294 1 1 1.2e-08 1.5e-07 0.4330 98 JMJD1C-AS1
4 14 103398706 104866687 3 1 6.7e-08 2.1e-07 0.6330 99 KLC1
5 15 77589535 79886142 13 9 1.9e-73 7.4e-76 1.0000 100 ADAMTS7 CHRNA5 DNAJA4 IREB2 PSMA4 RNU6-415P RP11-762H8.2
6 17 35152143 36441093 1 1 1.9e-07 1.1e-06 0.4390 98 DUSP14

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 1.39 1 0 0.0 0.00 1.0e+00 QRICH1
Irritable Bowel Disease (IBD) 1.94 1 1 3.0 0.00 1.0e+00 QRICH1
Ulcerative Colitis (UC) 1.96 1 1 3.0 0.00 1.0e+00 QRICH1
Major Depression (MDD) 1.73 1 0 0.0 0.00 1.0e+00 QRICH1
Verbal and Numeric Reasoning (VNR) 1.99 2 1 3.0 0.00 1.0e+00 JMJD1C-AS1 QRICH1
Breast Cancer 0.97 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Prostate Cancer 2.26 1 0 0.0 0.00 1.0e+00 QRICH1
Age at First Birth 2.36 1 0 0.0 0.00 1.0e+00 QRICH1
Coronary Artery Disease (CAD) 4.06 1 1 3.0 0.00 1.0e+00 ADAMTS7
Schizophrenia 3.69 2 2 6.1 0.00 1.0e+00 KLC1 PSMA4
Triglycerides 1.64 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Ulcerative Colitis 1.19 1 0 0.0 0.00 1.0e+00 QRICH1
Blood Eosinophil Count 1.08 2 1 3.0 0.00 1.0e+00 KLC1 QRICH1
Blood Platelet Count 1.21 4 3 9.1 0.89 4.5e-02 ADAMTS7 DUSP14 JMJD1C-AS1 RNU6-415P
Blood Red Count 1.42 7 2 6.1 0.70 7.7e-02 CHRNA5 DNAJA4 DUSP14 IREB2 JMJD1C-AS1 KLC1 PSMA4
Blood White Count 1.33 4 1 3.0 -0.45 5.5e-01 DUSP14 JMJD1C-AS1 KLC1 QRICH1
Heel T-Score 2.65 4 2 6.1 0.11 8.9e-01 AC004166.6 DUSP14 KLC1 QRICH1
BMI 1.67 3 2 6.1 0.00 1.0e+00 JMJD1C-AS1 KLC1 QRICH1
Height 0.74 3 2 6.1 0.00 1.0e+00 JMJD1C-AS1 KLC1 QRICH1
Waist Hip Ratio (WHR) 1.65 3 1 3.0 0.00 1.0e+00 ADAMTS7 JMJD1C-AS1 QRICH1
Systolic Blood Pressure 0.56 1 0 0.0 0.00 1.0e+00 QRICH1
Smoking Status 2.58 2 1 3.0 0.00 1.0e+00 KLC1 QRICH1
Allergy or Eczema 1.29 1 0 0.0 0.00 1.0e+00 PSMA4
Cardiovascular Disease 1.66 1 1 3.0 0.00 1.0e+00 KLC1
Hypothyroidism (self reported) 0.89 1 0 0.0 0.00 1.0e+00 QRICH1
Type 2 Diabetes (T2D) 1.69 2 0 0.0 0.00 1.0e+00 AC004166.6 KLC1
Lung FEV1/FVC ratio 2.31 5 1 3.0 0.85 3.3e-02 DUSP14 IREB2 JMJD1C-AS1 PSMA4 QRICH1
Lung FVC 2.16 4 2 6.1 0.84 7.8e-02 IREB2 JMJD1C-AS1 PSMA4 QRICH1
Neuroticism 1.32 1 0 0.0 0.00 1.0e+00 QRICH1
Hair Pigment 0.27 3 1 3.0 0.00 1.0e+00 ADAMTS7 JMJD1C-AS1 KLC1
Frequency of depressed mood in last 2 weeks 2.24 1 1 3.0 0.00 1.0e+00 JMJD1C-AS1
Hearing difficulty/problems: Yes 1.80 1 0 0.0 0.00 1.0e+00 KLC1
Systolic blood pressure, automated reading 1.20 1 0 0.0 0.00 1.0e+00 QRICH1
Angina 6.23 3 1 3.0 0.00 1.0e+00 ADAMTS7 CHRNA5 RNU6-415P
Medication: Co-codamol 1.64 1 0 0.0 0.00 1.0e+00 QRICH1
Medication: Metformin 1.60 1 0 0.0 0.00 1.0e+00 AC004166.6
Impedance of leg (right) 1.33 3 1 3.0 0.00 1.0e+00 JMJD1C-AS1 KLC1 QRICH1
Leg fat-free mass (left) 0.56 1 0 0.0 0.00 1.0e+00 KLC1
Trunk fat percentage 0.70 1 0 0.0 0.00 1.0e+00 KLC1
Townsend deprivation index at recruitment 2.65 1 0 0.0 0.00 1.0e+00 QRICH1
Current tobacco smoking 3.81 4 0 0.0 -0.23 7.7e-01 JMJD1C-AS1 KLC1 PSMA4 QRICH1
Maternal smoking around birth 5.35 4 0 0.0 0.95 5.1e-02 IREB2 KLC1 PSMA4 RNU6-415P
Fed-up feelings 2.30 1 1 3.0 0.00 1.0e+00 QRICH1
Frequency of unenthusiasm / disinterest in last 2 weeks 3.45 1 1 3.0 0.00 1.0e+00 JMJD1C-AS1
Taking other prescription medications 2.66 1 0 0.0 0.00 1.0e+00 QRICH1
Age when periods started (menarche) 3.51 3 1 3.0 0.00 1.0e+00 AC004166.6 PSMA4 QRICH1
Heel bone mineral density (BMD) T-score, automated (left) 2.08 1 1 3.0 0.00 1.0e+00 KLC1
Qualifications: CSEs or equivalent 4.40 2 0 0.0 0.00 1.0e+00 DNAJA4 JMJD1C-AS1
High blood pressure 1.30 2 0 0.0 0.00 1.0e+00 AC004166.6 KLC1
Multivitamins +/- minerals 4.48 1 0 0.0 0.00 1.0e+00 IREB2
Sitting height 0.58 2 0 0.0 0.00 1.0e+00 IREB2 QRICH1
Chronic bronchitis/emphysema (father) 12.73 4 3 9.1 0.99 4.7e-04 ADAMTS7 IREB2 PSMA4 RNU6-415P
Body mass index (BMI) 1.86 3 2 6.1 0.00 1.0e+00 JMJD1C-AS1 KLC1 QRICH1
Impedance of leg (left) 1.37 3 1 3.0 0.00 1.0e+00 JMJD1C-AS1 KLC1 QRICH1
Leg predicted mass (left) 0.53 1 0 0.0 0.00 1.0e+00 KLC1
Trunk fat mass 0.69 1 0 0.0 0.00 1.0e+00 KLC1
Waist circumference 0.97 1 1 3.0 0.00 1.0e+00 KLC1
Number of incorrect matches in round 1.53 1 0 0.0 0.00 1.0e+00 QRICH1
Past tobacco smoking 1.11 1 0 0.0 0.00 1.0e+00 KLC1
Frequency of tenseness / restlessness in last 2 weeks 2.98 2 1 3.0 0.00 1.0e+00 JMJD1C-AS1 QRICH1
Hearing difficulty/problems with background noise 2.65 1 0 0.0 0.00 1.0e+00 KLC1
Forced vital capacity (FVC) 2.25 4 1 3.0 -0.94 1.9e-02 IREB2 PSMA4 QRICH1 RP11-762H8.2
Heel bone mineral density (BMD) T-score, automated (right) 1.65 1 0 0.0 0.00 1.0e+00 KLC1
Ever unenthusiastic/disinterested for a whole week 1.64 1 0 0.0 0.00 1.0e+00 QRICH1
Qualifications: None of the above 3.55 2 2 6.1 0.00 1.0e+00 JMJD1C-AS1 QRICH1
Financial difficulties in last 2 years 3.11 1 0 0.0 0.00 1.0e+00 KLC1
Mouth/teeth dental problems 2.06 1 0 0.0 0.00 1.0e+00 KLC1
Pain all over the body in last month 3.40 1 0 0.0 0.00 1.0e+00 QRICH1
Diabetes (self-reported) 1.57 2 0 0.0 0.00 1.0e+00 AC004166.6 KLC1
Fluid intelligence score 1.92 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Neuroticism score 1.49 1 0 0.0 0.00 1.0e+00 QRICH1
Weight 0.78 1 0 0.0 0.00 1.0e+00 KLC1
Impedance of arm (right) 2.01 2 2 6.1 0.00 1.0e+00 JMJD1C-AS1 QRICH1
Arm fat percentage (right) 1.25 1 1 3.0 0.00 1.0e+00 KLC1
Hip circumference 1.13 3 0 0.0 0.00 1.0e+00 ADAMTS7 KLC1 QRICH1
Father's age at death 8.82 3 2 6.1 -0.98 1.6e-02 IREB2 PSMA4 QRICH1
Frequency of tiredness / lethargy in last 2 weeks 3.26 3 1 3.0 0.00 1.0e+00 JMJD1C-AS1 KLC1 QRICH1
Forced expiratory volume in 1-second (FEV1) 3.95 4 3 9.1 -0.95 1.2e-02 IREB2 PSMA4 QRICH1 RP11-762H8.2
Pulse rate 1.09 1 0 0.0 0.00 1.0e+00 QRICH1
Qualifications: A levels/AS levels or equivalent 2.71 3 1 3.0 0.00 1.0e+00 DUSP14 JMJD1C-AS1 QRICH1
Mouth/teeth dental problems: Dentures 4.18 2 0 0.0 0.00 1.0e+00 PSMA4 RNU6-415P
Lung cancer (father) 16.45 6 3 9.1 0.99 3.0e-05 ADAMTS7 DNAJA4 IREB2 PSMA4 QRICH1 RNU6-415P
Forced expiratory volume in 1-second (FEV1), Best measure 4.25 4 2 6.1 -0.97 7.2e-03 IREB2 PSMA4 QRICH1 RP11-762H8.2
Impedance of arm (left) 2.35 3 2 6.1 0.00 1.0e+00 JMJD1C-AS1 KLC1 QRICH1
Arm fat mass (right) 1.22 1 1 3.0 0.00 1.0e+00 KLC1
Standing height 0.68 2 1 3.0 0.00 1.0e+00 KLC1 QRICH1
Tense / 'highly strung' 1.92 1 0 0.0 0.00 1.0e+00 QRICH1
Peak expiratory flow (PEF) 1.79 2 0 0.0 0.00 1.0e+00 PSMA4 RP11-762H8.2
Qualifications: O levels/GCSEs or equivalent 2.12 1 0 0.0 0.00 1.0e+00 QRICH1
Medication: Paracetamol 2.19 2 0 0.0 0.00 1.0e+00 KLC1 QRICH1
Chronic bronchitis/emphysema (mother) 11.67 4 3 9.1 0.98 4.2e-03 CHRNA5 IREB2 PSMA4 RNU6-415P
Forced vital capacity (FVC), Best measure 2.53 3 1 3.0 -0.94 5.7e-02 IREB2 PSMA4 QRICH1
Body fat percentage 0.82 1 0 0.0 0.00 1.0e+00 KLC1
Leg fat percentage (right) 1.09 2 0 0.0 0.00 1.0e+00 KLC1 QRICH1
Arm fat-free mass (right) 0.54 2 0 0.0 0.00 1.0e+00 JMJD1C-AS1 QRICH1
Exposure to tobacco smoke outside home 1.87 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Number of full brothers 2.11 1 0 0.0 0.00 1.0e+00 QRICH1
Wheeze or whistling in the chest in last year 2.92 2 0 0.0 0.00 1.0e+00 IREB2 PSMA4
Age at first live birth 2.98 2 1 3.0 0.00 1.0e+00 JMJD1C-AS1 QRICH1
Qualifications: College or University degree 2.87 3 2 6.1 0.00 1.0e+00 DUSP14 JMJD1C-AS1 QRICH1
Emphysema/chronic bronchitis 4.59 1 0 0.0 0.00 1.0e+00 PSMA4
Medication for pain relief, constipation, heartburn 1.64 2 0 0.0 0.00 1.0e+00 JMJD1C-AS1 QRICH1
Neck or shoulder pain in last month 1.91 1 0 0.0 0.00 1.0e+00 QRICH1
Angina (self-reported) 6.46 3 2 6.1 0.00 1.0e+00 ADAMTS7 CHRNA5 RNU6-415P
Heart disease (mother) 5.08 3 0 0.0 0.00 1.0e+00 ADAMTS7 PSMA4 RNU6-415P
Whole body fat mass 0.90 1 0 0.0 0.00 1.0e+00 KLC1
Leg fat mass (right) 1.09 2 0 0.0 0.00 1.0e+00 KLC1 QRICH1
Pulse rate, automated reading 1.20 2 1 3.0 0.00 1.0e+00 KLC1 QRICH1
Alcohol intake frequency. 1.75 1 0 0.0 0.00 1.0e+00 AC004166.6
Comparative height size at age 10 1.01 3 0 0.0 0.00 1.0e+00 DUSP14 KLC1 QRICH1
Overall health rating 4.44 4 1 3.0 -0.34 6.6e-01 AC004166.6 KLC1 PSMA4 QRICH1
Chest pain or discomfort 1.46 1 0 0.0 0.00 1.0e+00 QRICH1
Age at last live birth 2.33 2 0 0.0 0.00 1.0e+00 AC004166.6 QRICH1
Knee pain experienced in last month 3.01 2 0 0.0 0.00 1.0e+00 IREB2 PSMA4
Hypertension (Self-reported) 1.38 2 0 0.0 0.00 1.0e+00 AC004166.6 KLC1
Illnesses of father: Heart disease 3.56 2 1 3.0 0.00 1.0e+00 ADAMTS7 RNU6-415P
Smoking status: Previous 2.36 1 0 0.0 0.00 1.0e+00 PSMA4
Leg fat-free mass (right) 0.48 1 0 0.0 0.00 1.0e+00 KLC1
Arm fat percentage (left) 1.12 1 1 3.0 0.00 1.0e+00 KLC1
Mood swings 2.16 2 1 3.0 0.00 1.0e+00 JMJD1C-AS1 QRICH1
Loneliness, isolation 2.83 2 0 0.0 0.00 1.0e+00 JMJD1C-AS1 QRICH1
Long-standing illness, disability or infirmity 2.98 1 0 0.0 0.00 1.0e+00 KLC1
Diabetes diagnosed by doctor 1.91 2 0 0.0 0.00 1.0e+00 AC004166.6 KLC1
Qualifications: nursing, teaching 2.27 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Smoking status: Current 2.51 2 0 0.0 0.00 1.0e+00 JMJD1C-AS1 KLC1
Forced expiratory volume in 1-second (FEV1), predicted percentage 9.73 7 3 9.1 -0.94 4.1e-04 ADAMTS7 CHRNA5 IREB2 JMJD1C-AS1 PSMA4 RNU6-415P RP11-762H8.2
Leg predicted mass (right) 0.49 1 0 0.0 0.00 1.0e+00 KLC1
Arm fat mass (left) 1.15 1 1 3.0 0.00 1.0e+00 KLC1
Number of self-reported non-cancer illnesses 2.50 2 0 0.0 0.00 1.0e+00 AC004166.6 KLC1
Miserableness 2.81 1 1 3.0 0.00 1.0e+00 QRICH1
Mother's age at death 4.26 2 0 0.0 0.00 1.0e+00 KLC1 PSMA4
Financial situation satisfaction 2.73 1 0 0.0 0.00 1.0e+00 QRICH1
Medication: Blood pressure 2.33 1 0 0.0 0.00 1.0e+00 ADAMTS7
Supplements: Fish oil (including cod liver oil) 2.14 1 0 0.0 0.00 1.0e+00 KLC1
Medication: Bendroflumethiazide 2.58 1 0 0.0 0.00 1.0e+00 ADAMTS7
Medication: Paracetamol 1.85 1 0 0.0 0.00 1.0e+00 QRICH1
Ever smoked 2.98 2 0 0.0 0.00 1.0e+00 IREB2 PSMA4
Leg fat percentage (left) 1.12 2 0 0.0 0.00 1.0e+00 KLC1 QRICH1
Arm fat-free mass (left) 0.76 2 0 0.0 0.00 1.0e+00 JMJD1C-AS1 QRICH1
Number of operations (self-reported) 1.28 1 0 0.0 0.00 1.0e+00 QRICH1
Irritability 2.00 1 0 0.0 0.00 1.0e+00 QRICH1
Risk taking 4.45 2 0 0.0 0.00 1.0e+00 KLC1 PSMA4
Diastolic blood pressure, automated reading 2.39 3 1 3.0 0.00 1.0e+00 ADAMTS7 KLC1 QRICH1
Ever depressed for a whole week 2.33 1 0 0.0 0.00 1.0e+00 QRICH1
Unable to work because of sickness or disability 3.91 1 0 0.0 0.00 1.0e+00 RNU6-415P
Vascular/heart problems diagnosed by doctor 1.24 1 0 0.0 0.00 1.0e+00 KLC1
Pain experienced in last month 2.41 1 0 0.0 0.00 1.0e+00 QRICH1
Heart disease (siblings) 2.16 1 0 0.0 0.00 1.0e+00 ADAMTS7
Pack years of smoking 57.49 12 10 30.3 1.00 1.8e-21 AC004166.6 ADAMTS7 CHRNA5 DNAJA4 DUSP14 IREB2 JMJD1C-AS1 KLC1 PSMA4 QRICH1 RNU6-415P RP11-762H8.2
Impedance of whole body 2.02 3 2 6.1 0.00 1.0e+00 JMJD1C-AS1 KLC1 QRICH1
Leg fat mass (left) 1.15 2 0 0.0 0.00 1.0e+00 KLC1 QRICH1
Arm predicted mass (left) 0.75 2 0 0.0 0.00 1.0e+00 JMJD1C-AS1 QRICH1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.0573 1.60
GTEx Adipose Visceral Omentum 1 0.0491 1.55
GTEx Adrenal Gland 1 0.0686 1.47
GTEx Artery Aorta 1 0.0336 1.56
GTEx Artery Coronary 1 0.0845 1.55
GTEx Artery Tibial 2 0.0532 1.58
GTEx Brain Caudate basal ganglia 1 0.1087 1.65
GTEx Brain Cerebellar Hemisphere 1 0.0672 1.59
GTEx Brain Cerebellum 1 0.0505 1.56
GTEx Brain Cortex 2 0.1932 1.74
GTEx Brain Frontal Cortex BA9 1 0.1082 1.67
GTEx Brain Hippocampus 1 0.1908 1.61
GTEx Brain Hypothalamus 1 0.1695 1.61
GTEx Brain Nucleus accumbens basal ganglia 1 0.1156 1.68
GTEx Brain Putamen basal ganglia 2 0.3205 1.71
GTEx Breast Mammary Tissue 1 0.0507 1.65
GTEx Breast Mammary Tissue (Male) 1 0.0838 1.56
GTEx Breast Mammary Tissue (Female) 1 0.0608 1.57
GTEx Cells EBV-transformed lymphocytes 2 0.1405 1.55
GTEx Cells Transformed fibroblasts 2 0.0476 1.48
GTEx Colon Sigmoid 1 0.0684 1.57
GTEx Colon Transverse 1 0.0484 1.56
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.61
GTEx Esophagus Mucosa 2 0.0602 1.51
GTEx Esophagus Muscularis 0 0.0000 1.53
GTEx Heart Atrial Appendage 0 0.0000 1.49
GTEx Heart Left Ventricle 2 0.1307 1.62
GTEx Liver 1 0.1395 1.87
GTEx Lung 1 0.0348 1.55
GTEx Muscle Skeletal 1 0.0346 1.58
GTEx Nerve Tibial 3 0.0694 1.52
GTEx Ovary 1 0.1101 1.72
GTEx Pancreas 0 0.0000 1.51
GTEx Pituitary 1 0.0897 1.51
GTEx Prostate 1 0.1198 1.53
GTEx Skin Not Sun Exposed Suprapubic 1 0.0407 1.56
GTEx Skin Sun Exposed Lower leg 3 0.0824 1.58
GTEx Small Intestine Terminal Ileum 0 0.0000 1.44
GTEx Spleen 2 0.1417 1.59
GTEx Stomach 0 0.0000 1.57
GTEx Testis 3 0.0951 1.58
GTEx Thyroid 0 0.0000 1.52
GTEx Uterus 0 0.0000 1.39
GTEx Vagina 0 0.0000 1.48
GTEx Whole Blood 0 0.0000 1.50
METSIM Adipose 2 0.0434 1.48
NTR Blood 0 0.0000 1.41
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.50
YFS Blood 2 0.0433 1.55
CommonMind Brain Pre-frontal Cortex 4 0.0744 1.51
TCGA Breast Tumor 3 0.3911 1.82
TCGA Breast Normal 1 0.0238 1.37
TCGA Ovarian Tumor 1 0.0342 1.41
TCGA Prostate Tumor 2 0.0578 1.62