TWAS hub - COMMD7

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0460	0.0190	9.0e-04	0.026	0.024	0.023	0.024	0.034	3.6e-04	5.2e-04	6.8e-04	6.3e-04	4.9e-05
2	GTEx	Colon Transverse	0.1610	0.0730	9.8e-04	0.012	NA	-0.006	NA	0.002	8.6e-02	NA	8.4e-01	NA	2.5e-01
3	GTEx	Esophagus Mucosa	0.0770	0.0360	5.3e-03	0.033	NA	0.033	NA	0.023	2.9e-03	NA	2.9e-03	NA	1.1e-02
4	GTEx	Esophagus Muscularis	0.1610	0.0730	1.1e-03	0.026	NA	0.005	NA	0.014	1.0e-02	NA	1.5e-01	NA	4.4e-02
5	GTEx	Muscle Skeletal	0.1353	0.0389	1.9e-07	0.129	NA	0.098	NA	0.121	1.2e-12	NA	7.4e-10	NA	7.5e-12
6	GTEx	Nerve Tibial	0.0911	0.0372	1.5e-03	0.043	NA	0.066	NA	0.073	5.1e-04	NA	1.9e-05	NA	7.4e-06
7	GTEx	Testis	0.1120	0.0560	5.6e-03	0.013	NA	-0.004	NA	0.008	8.5e-02	NA	5.2e-01	NA	1.3e-01
8	METSIM	Adipose	0.0421	0.0191	2.0e-03	0.022	0.014	0.012	0.016	0.011	2.3e-04	3.1e-03	5.3e-03	1.7e-03	7.9e-03
9	ROSMAP	Brain Pre-frontal Cortex	0.1508	0.0393	2.5e-11	0.089	0.098	0.120	0.113	0.125	1.6e-11	1.6e-12	3.9e-15	2.2e-14	8.9e-16
10	TCGA	Breast Invasive Carcinoma	0.0273	0.0155	5.2e-05	0.021	0.017	0.009	NA	0.013	2.5e-05	1.4e-04	5.6e-03	NA	1.0e-03
11	TCGA	Prostate Adenocarcinoma	0.0357	0.0199	1.2e-04	0.011	0.025	0.013	NA	0.014	2.1e-02	9.9e-04	1.5e-02	NA	1.2e-02
12	TCGA	Testicular Germ Cell Tumors	0.1380	0.0920	2.8e-03	0.053	0.058	0.074	NA	0.091	5.9e-03	4.1e-03	1.4e-03	NA	4.0e-04
13	TCGA	Thyroid Carcinoma	0.0530	0.0290	5.3e-04	0.041	0.031	0.020	NA	0.023	7.4e-05	5.2e-04	4.4e-03	NA	2.2e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Hair/balding pattern: Pattern 2	13.9	17.6	30.4	-5.5	-5.2	-4.1	-4.3	-4.1	-3.8	-3.1	-2.3	-5.1	-4.5	-4.9	-4.4	1.1
Neck or shoulder pain in last month	9.4	13.4	19.9	4.0	4.4	3.1	3.6	4.2	2.2	3.6	3.4	4.5	4.3	4.4	2.8	-1.9
Birth weight	9.1	19.8	64.1	3.3	4.3	-0.7	2.2	7.7	-2.5	5.7	1.3	4.8	2.4	5.4	0.3	-8.0
Pulse wave peak to peak time	8.7	10.3	19.1	-3.7	-3.4	-4.4	-3.5	-2.4	-3.4	-2.7	-2.3	-3.6	-3.9	-3.3	-2.9	0.3
Pain experienced in last month	8.4	14.1	21.2	-4.2	-4.4	-3.1	-3.7	-3.8	-2.6	-3.4	-4.6	-4.4	-4.4	-4.2	-3.2	1.5
Pulse wave Arterial Stiffness index	7.9	9.2	15.1	3.5	3.3	3.9	3.3	2.6	3.0	2.6	2.1	3.5	3.6	3.2	2.7	-0.7
Long-standing illness, disability or infirmity	7.6	11.7	19.3	4.4	4.4	2.7	3.0	3.5	3.1	2.4	3.0	4.0	3.9	3.7	3.8	-1.0
Number of treatments/medications taken	7.2	13.0	20.6	4.1	4.4	3.6	3.6	1.8	4.0	2.4	4.4	3.9	4.5	3.5	3.7	1.2
Alcohol usually taken with meals	7.2	11.7	21.8	-4.1	-4.7	-2.9	-2.6	-3.7	-2.8	-2.4	-2.9	-3.8	-3.5	-4.2	-3.8	1.6
Prostate Cancer	6.9	9.7	18.4	-3.1	-3.7	-3.0	-3.4	-2.9	-2.5	-3.4	-2.6	-3.9	-4.3	-3.5	-2.0	0.9
Serious illness, injury or assault to yourself	6.8	8.3	13.1	3.6	2.8	3.6	2.9	1.3	3.6	1.5	3.1	2.8	3.2	2.8	3.5	0.9
Past tobacco smoking	6.7	12.3	26.3	-4.2	-4.2	-3.3	-3.5	-2.1	-3.2	-2.3	-5.1	-4.0	-4.2	-3.4	-3.3	-0.5
Smoking status: Previous	6.7	10.0	18.6	3.7	3.9	3.2	3.0	2.0	2.9	2.2	4.3	3.7	3.9	3.1	2.8	0.2
Medication for pain relief, constipation, heartburn	6.6	11.2	19.1	-4.1	-4.4	-3.5	-2.8	-2.3	-3.7	-1.6	-4.0	-3.7	-3.6	-3.4	-3.9	-0.4
Medication: Ibuprofen (e.g. Nurofen)	6.5	8.2	16.7	2.7	4.1	2.6	1.9	3.5	1.7	2.8	2.7	3.3	2.8	3.5	2.2	-2.5
Back pain experienced in last month	6.4	9.3	19.5	3.0	4.4	2.4	2.6	3.5	1.8	3.1	2.8	3.5	3.6	3.5	2.2	-2.1
Medication: Paracetamol	6.4	9.8	18.0	4.1	3.3	2.8	2.7	2.4	3.2	1.3	4.2	3.3	3.1	3.3	4.2	0.4
Other serious medical condition/disability diagnosed by doctor	6.1	8.0	12.3	3.1	3.5	2.9	3.1	2.1	2.4	3.1	3.2	3.0	2.8	3.1	2.6	-0.8
Shortness of breath walking on level ground	6.0	7.1	17.2	3.0	2.3	3.5	2.7	1.7	2.7	1.5	4.2	2.6	3.0	2.3	2.9	0.0
Ulcerative Colitis	5.8	8.4	16.2	3.1	3.8	3.2	2.7	2.3	2.6	1.9	4.0	3.0	3.0	3.0	2.6	-0.6
Falls in the last year	5.7	7.7	17.2	2.9	3.0	2.7	4.1	1.5	2.8	3.8	1.6	3.1	2.4	3.1	2.4	-0.3
Medication: Ibuprofen	5.5	6.5	13.2	2.5	3.6	2.4	1.5	3.0	1.7	2.1	2.7	3.0	2.8	3.1	2.1	-1.8
Reaction Time	5.1	9.7	18.7	-3.7	-3.1	-3.5	-3.0	-0.6	-4.3	-0.7	-4.3	-2.6	-3.2	-2.2	-4.1	-2.2
Medication: Paracetamol	5.0	8.2	15.0	3.8	3.1	2.5	2.6	2.3	2.8	1.4	3.7	3.1	2.7	3.0	3.9	-0.0
Ever smoked	5.0	8.8	16.1	3.4	3.7	2.6	3.1	2.0	2.4	2.8	4.0	3.5	3.5	3.0	2.4	-0.2
Pack years of smoking	5.0	7.3	13.5	3.2	3.7	2.2	2.5	2.6	1.9	2.7	2.2	3.3	3.1	3.3	2.3	-0.9
Systolic Blood Pressure	4.9	24.6	47.2	5.0	6.9	4.0	4.9	5.4	2.6	6.2	3.2	5.9	4.8	6.3	3.4	-3.9
Health satisfaction	4.9	6.3	9.4	2.7	2.9	3.0	2.7	1.5	2.7	1.9	2.8	2.7	3.1	2.3	2.6	0.3
Qualifications: CSEs or equivalent	4.8	6.3	14.1	2.6	3.0	2.0	2.6	1.7	1.8	2.9	3.8	2.8	2.4	2.8	2.1	-0.8
Unable to work because of sickness or disability	4.6	5.9	12.0	2.5	2.9	3.5	2.9	0.9	3.0	1.8	2.2	2.5	2.7	2.2	2.4	0.9
Mouth/teeth dental problems: Dentures	4.4	7.3	13.5	3.4	3.1	1.4	2.6	2.9	2.3	1.3	3.1	3.2	3.7	2.9	2.9	-0.5
Mean time to correctly identify matches	4.2	8.0	18.2	-3.2	-3.0	-3.1	-2.7	-0.4	-3.7	-0.9	-4.3	-2.4	-2.9	-2.1	-3.4	-2.0
Overall health rating	4.2	9.1	13.4	3.7	3.5	3.2	3.1	2.1	2.9	2.4	3.3	3.3	3.3	3.1	3.3	0.0
Hearing aid user	4.1	4.7	8.6	2.7	2.2	2.3	2.7	0.9	2.9	1.1	1.9	2.2	2.4	2.0	2.5	1.2
Financial situation satisfaction	4.1	5.1	8.1	2.8	2.4	1.1	1.9	2.8	1.3	2.3	1.7	2.6	2.4	2.6	2.5	-2.2
Average weekly champagne plus white wine intake	4.0	5.5	10.5	-2.3	-2.7	-3.2	-2.4	-2.0	-2.0	-2.4	-2.1	-2.6	-2.2	-2.9	-1.9	0.8
Ever had prostate specific antigen (PSA) test	3.9	4.5	11.0	-2.2	-2.0	-3.2	-2.0	0.2	-3.3	-0.5	-2.1	-1.5	-2.2	-1.1	-2.7	-2.0
Pack years adult smoking proportion	3.8	5.8	10.6	2.9	3.3	1.8	2.1	2.4	1.6	2.5	2.2	2.9	2.7	3.0	2.1	-0.9
Number of self-reported non-cancer illnesses	3.8	6.7	13.7	3.0	3.7	2.3	2.4	2.5	1.8	2.4	2.5	3.0	2.7	3.0	2.2	-1.1
Medication: Omeprazole (e.g. Zanprol)	3.8	4.6	9.4	2.5	1.8	2.7	2.5	-0.0	3.1	0.9	2.5	1.6	2.1	1.3	2.9	1.9
Ulcerative Colitis (UC)	3.7	6.9	12.4	3.0	3.5	2.8	2.2	2.3	2.2	1.9	3.5	2.7	2.5	2.8	2.7	-1.1
Supplements: Glucosamine	3.6	4.7	7.5	2.6	2.0	1.7	2.7	1.6	2.2	2.3	1.9	2.5	2.4	2.1	2.5	-0.0
Noisy workplace	3.6	4.5	7.5	2.7	2.3	1.9	1.9	1.2	2.2	0.5	2.6	2.2	2.7	2.2	2.5	1.1
Hair/balding pattern: Pattern 4	3.6	8.7	20.9	-3.1	-2.4	-4.6	-3.7	0.7	-4.3	-1.6	-1.4	-2.4	-3.0	-2.1	-3.0	-3.2
Headache pain in last month	3.6	6.3	10.0	2.8	2.8	2.0	2.1	3.1	1.6	2.0	3.2	2.8	2.5	2.7	2.3	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	3.6	4.7	8.2	2.1	2.2	2.5	2.9	0.9	2.4	2.0	2.5	2.2	2.8	2.0	1.9	0.6
Leg pain on walking	3.6	4.5	7.8	2.3	2.1	2.6	1.9	0.9	2.8	0.9	2.8	2.1	2.5	1.8	2.4	1.0
Illnesses of father: High blood pressure	3.5	4.3	6.7	2.4	2.4	2.6	2.0	1.2	2.5	1.5	2.2	2.3	2.2	1.9	2.4	0.1
Smoking Status	3.4	8.2	31.8	3.1	3.1	1.9	2.6	1.7	2.4	1.8	5.6	3.0	3.1	2.7	2.8	0.4
Mouth/teeth dental problems	3.4	5.2	10.0	-3.2	-2.7	-1.4	-2.0	-2.3	-1.8	-1.4	-2.5	-2.5	-2.4	-2.5	-3.1	0.8
Taking other prescription medications	3.3	5.0	9.5	2.7	2.6	2.0	2.0	0.8	2.7	1.2	3.1	2.2	2.9	1.8	2.6	1.2
Wears glasses or contact lenses	3.2	3.6	7.4	1.5	2.5	2.0	2.2	1.9	0.9	2.5	1.1	2.4	2.7	2.1	0.1	-0.8
Tanning	3.1	37.4	85.6	6.5	9.2	7.9	6.2	3.9	6.4	5.6	4.9	6.3	6.7	5.4	5.7	-1.0
Medication: Atenolol	3.1	3.8	6.6	1.9	2.3	2.2	2.1	2.1	1.5	1.6	1.3	2.5	2.5	2.6	1.0	-0.6
Medication: Blood pressure	3.1	5.5	12.5	2.1	3.5	2.3	2.0	2.8	1.2	2.4	1.5	2.9	2.4	3.0	1.3	-1.8
Irritable Bowel Disease (IBD)	3.0	7.0	12.2	3.3	3.3	2.4	2.1	2.2	2.6	1.6	3.5	2.6	2.6	2.8	3.4	-0.6
Age at First Birth	3.0	4.4	7.0	-2.6	-2.4	-0.7	-1.5	-2.6	-1.3	-1.4	-2.4	-2.6	-1.8	-2.6	-2.4	1.4
Hypothyroidism (self reported)	3.0	7.0	13.5	-3.5	-3.1	-2.1	-2.5	-2.1	-3.2	-1.3	-1.0	-3.0	-2.9	-3.2	-3.7	-0.3
Systolic blood pressure, automated reading	3.0	8.7	15.4	3.1	3.9	3.0	3.2	2.6	2.4	3.3	1.6	3.6	3.2	3.5	2.5	-1.2
Breastfed as a baby	3.0	3.8	6.7	-2.0	-2.0	-2.1	-2.0	-0.6	-2.6	-1.4	-2.4	-1.7	-2.3	-1.6	-2.5	-0.6
Hand grip strength (left)	2.8	7.5	18.3	-2.8	-2.3	-4.3	-3.2	-0.1	-3.5	-2.3	-3.0	-2.4	-2.9	-2.0	-2.6	-1.9
Hand grip strength (right)	2.8	7.7	19.7	-2.6	-2.4	-4.4	-3.4	-0.2	-3.5	-2.0	-3.1	-2.6	-3.1	-2.2	-2.2	-2.1
Illness, injury, bereavement, stress in last 2 years	2.8	3.4	6.3	-1.9	-2.5	-1.8	-1.2	-1.5	-1.3	-1.8	-2.3	-2.2	-2.2	-2.2	-1.3	0.6
Average weekly fortified wine intake	2.7	3.2	7.7	-1.6	-2.3	-0.6	-0.8	-2.8	-0.1	-1.3	-2.2	-2.4	-1.8	-2.5	-0.8	1.7
Stomach or abdominal pain in last month	2.7	3.4	6.0	1.6	2.4	1.6	1.6	2.1	0.6	2.0	2.5	2.2	2.3	1.9	0.8	-1.2
Mineral and other dietary supplements	2.7	3.6	6.7	-1.9	-1.7	-1.3	-2.5	-1.7	-1.3	-1.9	-2.4	-2.6	-2.5	-2.1	-1.3	0.1
Pain all over the body in last month	2.6	2.8	6.5	2.2	0.9	1.9	2.5	0.5	2.1	1.4	1.0	1.8	1.7	1.5	1.9	0.9
Hair/balding pattern: Pattern 3	2.6	3.8	9.5	2.6	2.2	2.5	1.8	0.4	3.1	0.4	-0.8	1.6	1.7	1.8	2.9	1.1
Birth weight of first child	2.6	4.8	13.4	1.4	1.9	-0.9	1.5	3.7	-1.5	2.7	1.0	2.5	1.7	2.8	-0.2	-3.5
Pulse wave reflection index	2.6	3.2	5.5	1.4	1.7	1.8	1.6	2.0	0.7	2.3	2.3	2.1	2.0	2.2	0.9	-1.6
Vascular/heart problems diagnosed by doctor	2.6	7.0	14.8	-2.3	-3.7	-2.1	-1.7	-3.8	-0.8	-2.9	-1.2	-3.1	-2.6	-3.4	-1.3	3.3
Frequency of tenseness / restlessness in last 2 weeks	2.5	3.9	6.4	2.1	2.4	2.1	1.7	2.3	1.0	1.9	2.0	2.5	2.3	2.3	1.1	-1.3
Supplements: Fish oil (including cod liver oil)	2.5	3.2	6.5	1.5	1.7	0.9	1.9	2.6	0.3	2.2	1.7	2.4	2.2	2.1	0.7	-1.6
Medication: Ramipril	2.4	3.1	5.0	2.1	2.2	1.4	1.6	1.7	1.1	2.1	1.7	1.9	1.5	2.2	1.7	-1.1
Medication: Amlodipine	2.4	3.4	7.3	2.0	2.6	0.9	1.1	2.7	0.6	1.6	0.1	2.4	1.7	2.7	1.4	-1.7
Loud music exposure frequency	2.3	2.5	4.5	2.1	1.7	0.8	1.5	1.7	1.1	1.4	0.8	2.0	1.7	2.1	1.9	-0.6
Comparative height size at age 10	2.3	12.5	34.9	-2.6	-1.9	-5.9	-4.1	2.4	-5.4	-1.8	-2.8	-2.1	-3.8	-1.4	-2.8	-5.2
Guilty feelings	2.2	3.3	6.7	2.0	1.7	1.9	1.9	0.8	1.8	2.0	2.6	2.0	1.8	1.8	1.9	0.1
Heart attack	2.1	2.7	6.6	1.4	2.6	1.4	1.6	1.8	0.8	1.9	1.1	1.8	2.1	2.2	0.7	-0.9
Cardiovascular Disease	2.0	6.7	14.3	2.4	3.8	2.3	1.8	3.4	0.8	2.4	2.5	3.0	2.7	3.2	1.5	-2.4
Chronic bronchitis/emphysema (father)	2.0	2.4	5.3	1.9	1.4	1.6	2.3	-0.0	2.1	1.3	1.4	1.2	1.2	1.2	2.0	1.2
Lung cancer (father)	2.0	2.4	4.4	2.0	2.1	1.3	1.3	1.8	1.4	1.2	0.6	1.4	1.4	1.8	1.9	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.3	4.0	1.6	1.8	1.7	2.0	1.1	1.0	1.6	1.7	1.8	1.8	1.6	0.8	-0.0
Mother’s age at death	2.0	2.5	6.2	-2.3	-1.1	-0.9	-1.6	-1.0	-1.4	-0.9	-2.1	-1.6	-1.7	-1.5	-2.5	-0.3
Verbal and Numeric Reasoning (VNR)	1.9	4.6	9.1	-2.4	-2.1	-3.0	-2.0	-0.4	-3.0	-0.6	-2.2	-1.9	-2.2	-2.1	-2.6	-1.7
Father’s age at death	1.9	2.5	5.0	-2.2	-1.1	-1.5	-1.9	-1.0	-2.2	-0.7	-1.7	-1.6	-1.5	-1.2	-2.2	0.3
Pulse rate	1.9	3.2	10.2	1.7	1.1	2.5	2.1	-1.1	3.2	0.5	0.8	1.0	1.7	0.4	2.0	2.6
Hypothyroidism/myxoedema (self-reported)	1.9	3.8	7.0	-2.5	-2.6	-1.1	-1.7	-2.0	-1.7	-1.4	-0.4	-2.3	-1.9	-2.6	-2.5	0.6
Medication: Omeprazole	1.9	2.2	5.0	1.5	0.8	1.7	1.8	-0.4	2.1	0.2	2.2	0.7	1.2	0.5	2.0	1.9
Medication: Atorvastatin	1.9	2.3	6.4	1.3	2.5	1.4	1.0	1.4	0.8	1.4	1.9	1.8	2.1	1.7	0.6	-0.4
Heart attack/myocardial infarction (self-reported)	1.9	2.4	6.1	1.2	2.5	1.3	1.5	1.7	0.6	2.0	1.0	1.7	1.9	2.0	0.4	-1.1
HDL Cholesterol	1.8	3.0	6.2	1.1	2.2	1.2	1.7	1.7	0.4	2.5	2.0	2.2	2.0	2.2	-0.0	-1.1
High blood pressure	1.8	4.9	9.6	2.1	3.0	2.2	1.5	3.1	0.9	2.2	1.1	2.7	2.2	2.7	1.3	-2.5
Forced vital capacity (FVC)	1.8	6.9	21.5	-2.5	-1.8	-4.3	-2.2	0.8	-4.6	-0.2	-0.9	-1.8	-2.9	-1.2	-3.0	-3.5
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.0	4.6	1.1	2.2	1.1	1.0	1.5	0.7	1.8	1.5	1.7	1.5	1.7	0.9	-1.1
Gout (self-reported)	1.8	2.4	3.8	1.7	1.6	2.0	1.9	0.8	1.8	1.2	1.9	1.3	1.5	1.4	1.9	0.1
Forced vital capacity (FVC), Best measure	1.8	6.6	19.1	-2.6	-2.4	-4.1	-1.9	0.5	-4.4	-0.5	-1.0	-1.7	-2.8	-1.4	-3.3	-3.0
Number of full brothers	1.8	2.3	4.3	1.8	1.9	0.8	1.9	1.0	1.3	1.2	1.4	1.8	1.5	2.1	1.6	0.4
Had major operations	1.8	2.2	4.4	-1.5	-1.1	-1.9	-2.0	-0.1	-1.6	-0.9	-2.1	-1.5	-1.6	-1.2	-1.2	-1.3
Medication: Blood pressure	1.8	3.5	6.0	2.1	2.3	1.3	1.3	2.5	0.8	1.9	0.8	2.4	2.1	2.4	1.5	-1.7
Intelligence (Savage-Jansen 2018)	1.7	5.1	9.5	-2.4	-2.3	-2.5	-2.2	-0.6	-2.9	-0.4	-3.1	-2.4	-2.7	-2.2	-2.0	-1.9
Lung FVC	1.7	8.6	20.1	-3.6	-4.5	-3.0	-2.3	-2.7	-2.5	-3.1	-0.5	-3.2	-2.5	-3.6	-3.3	1.2
Medication: Lansoprazole	1.7	1.9	5.1	1.0	1.1	2.2	1.2	-0.1	1.7	-0.4	2.2	0.9	1.7	0.6	0.7	1.9
Medication for cholesterol, blood pressure or diabetes	1.7	2.7	6.3	-1.7	-2.5	-1.9	-1.5	-1.4	-1.5	-1.2	-1.5	-2.0	-1.8	-1.9	-1.4	0.1
Chronic bronchitis/emphysema (mother)	1.7	2.0	6.8	-1.1	-1.3	-1.6	-1.6	-0.6	-1.3	-1.1	-2.6	-1.6	-1.7	-1.2	-0.6	-0.4
Mouth/teeth dental problems: Loose teeth	1.7	2.0	5.8	2.2	1.2	0.4	1.0	1.4	1.6	0.5	0.1	1.7	1.5	1.6	2.4	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.6	13.2	-1.7	-3.6	-2.7	-0.9	-1.4	-2.0	-1.7	-0.2	-1.8	-1.8	-1.8	-1.7	0.9
High cholesterol (Self-reported)	1.7	3.0	6.3	1.7	2.5	1.7	1.7	1.1	1.2	1.5	2.5	1.9	1.8	2.0	1.3	0.6
Impedance of leg (right)	1.6	7.8	17.4	2.7	2.5	3.2	4.2	-0.8	3.3	2.9	3.6	2.1	2.1	2.4	2.7	2.3
Multivitamins +/- minerals	1.6	2.1	9.3	-0.1	-0.2	-1.1	0.2	2.1	-1.8	2.2	-1.2	0.9	-0.0	0.9	-1.1	-3.1
Impedance of leg (left)	1.6	7.8	17.6	2.6	2.1	3.4	4.2	-1.1	3.4	2.8	4.1	1.9	1.9	2.1	2.7	2.3
Had menopause	1.6	2.0	3.8	2.0	1.9	1.8	1.4	0.5	1.6	0.6	1.2	1.3	1.2	1.3	2.0	0.7
Forced expiratory volume in 1-second (FEV1)	1.6	5.6	16.0	-2.3	-2.4	-4.0	-2.1	-0.0	-4.0	-0.9	0.1	-1.9	-2.7	-1.5	-2.5	-2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	3.8	1.6	1.7	1.1	0.8	0.4	1.9	-0.6	0.3	1.6	1.9	0.9	1.7	1.6
Osteoarthritis (self-reported)	1.6	2.1	4.0	2.0	1.4	1.2	1.4	1.8	1.3	1.0	1.0	1.7	1.1	1.7	1.8	-0.9
Illnesses of father: None of the above (group 1)	1.6	1.9	4.1	-1.4	-1.6	-2.0	-1.9	0.1	-1.9	-1.1	-0.4	-1.3	-1.7	-1.0	-1.1	-1.2
Crohns Disease (2012)	1.5	2.4	6.4	2.1	1.7	0.7	0.4	1.6	1.7	0.1	1.6	1.5	1.9	1.7	2.5	0.1
Hearing difficulty/problems: Yes	1.5	2.3	7.2	1.5	-0.2	1.2	0.8	-1.0	2.4	-1.5	1.6	0.1	0.6	0.2	2.6	2.7
Financial difficulties in last 2 years	1.5	2.0	7.1	1.4	1.4	1.6	1.2	1.1	0.7	1.5	2.7	1.5	1.4	1.2	0.9	-0.8
Comparative body size at age 10	1.5	4.3	7.1	-2.3	-1.5	-2.4	-2.4	-1.0	-2.6	-1.8	-2.5	-2.0	-1.9	-2.1	-2.7	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.2	16.4	-0.1	1.1	-1.6	-0.5	2.6	-2.7	1.6	-0.2	0.6	-0.9	1.3	-1.2	-4.0
Medication for cholesterol	1.5	2.3	5.7	-1.9	-2.4	-1.0	-0.3	-1.8	-1.0	-0.6	-1.0	-1.6	-1.9	-1.9	-2.0	0.6
Major Depression (MDD)	1.4	1.7	4.5	1.2	1.1	0.8	1.0	1.8	0.6	0.9	2.1	1.7	1.5	1.4	0.9	-1.1
Qualifications: None of the above	1.4	2.9	5.4	2.3	1.4	1.0	1.6	1.0	2.2	0.2	1.3	2.0	2.2	1.9	2.2	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.4	13.4	-2.1	-2.3	-3.7	-1.5	0.1	-3.6	-0.7	0.5	-1.4	-2.2	-1.2	-2.6	-1.9
Standing height	1.4	13.6	62.5	-1.3	0.7	-5.4	-2.5	4.6	-6.0	1.6	-2.2	-0.2	-2.7	1.1	-2.3	-7.9
Exposure to tobacco smoke at home	1.4	1.5	3.2	1.3	0.8	1.6	1.5	-0.2	1.8	0.3	1.5	1.0	1.6	0.7	1.1	1.4
Leg fat percentage (right)	1.4	5.1	11.1	2.7	2.3	3.1	2.0	0.1	3.3	0.2	1.9	1.7	2.3	1.6	3.2	2.1
Medication: Allopurinol	1.4	1.9	3.2	1.6	1.8	1.2	1.4	1.4	1.2	1.3	1.3	1.4	1.4	1.5	1.6	-0.7
Average weekly red wine intake	1.4	2.0	7.2	-0.7	-0.4	-1.5	-0.8	1.3	-2.2	1.2	-2.3	0.1	-0.7	0.2	-1.4	-2.7
Ever depressed for a whole week	1.4	1.8	6.4	0.6	1.2	-1.2	-0.5	2.5	-1.5	0.6	1.1	1.3	0.5	1.4	0.1	-2.4
Alcohol drinker status: Previous	1.4	1.6	6.7	1.1	1.2	0.6	1.7	1.0	0.1	2.6	1.0	1.5	0.8	1.5	0.4	-1.1
Neuroticism (2016)	1.3	1.8	4.9	1.1	1.2	0.3	1.3	1.3	-0.3	2.2	2.2	1.3	0.9	1.4	0.5	-1.9
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	6.3	0.7	1.0	-1.1	0.3	1.7	-1.1	1.0	2.5	1.2	0.5	1.4	0.1	-1.6
Hypertension (Self-reported)	1.3	3.5	7.5	1.7	2.6	2.0	1.1	2.7	0.7	1.6	1.0	2.3	1.8	2.3	1.0	-2.2
Leg fat percentage (left)	1.3	4.6	10.8	2.5	2.0	3.1	1.8	-0.1	3.3	-0.1	2.0	1.5	2.1	1.3	3.1	2.0
Supplements: Calcium	1.3	1.4	2.8	1.4	1.0	1.2	1.7	0.9	0.7	1.4	1.0	1.6	1.6	1.2	0.4	-0.0
Basal cell carcinoma (self-reported)	1.3	1.6	3.3	1.3	1.3	1.2	1.3	1.2	0.5	1.1	1.2	1.8	1.7	1.7	0.4	-0.2
Height	1.2	22.6	100.0	-1.6	0.6	-6.8	-3.4	6.0	-7.8	1.7	-2.9	-0.3	-3.4	1.3	-3.1	-10.0
Leg fat-free mass (left)	1.2	6.1	21.3	-1.3	0.0	-3.4	-3.1	2.8	-3.7	-0.7	-2.5	-0.7	-1.7	-0.3	-1.6	-4.6
Leg predicted mass (left)	1.2	6.1	20.8	-1.3	-0.0	-3.5	-3.2	2.8	-3.7	-0.8	-2.6	-0.7	-1.7	-0.4	-1.6	-4.6
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	2.8	-1.4	-1.5	-1.1	-1.0	-1.4	-0.6	-1.1	-1.1	-1.5	-1.6	-1.7	-1.0	0.7
Trunk fat-free mass	1.2	7.0	33.3	-0.7	1.0	-3.4	-2.5	3.8	-3.9	0.7	-2.0	0.1	-1.2	0.7	-1.4	-5.8
Happiness	1.2	1.5	4.5	0.9	0.8	0.3	0.4	2.1	-0.1	0.9	1.8	1.3	0.9	1.4	0.8	-2.0
Qualifications: A levels/AS levels or equivalent	1.2	2.7	6.4	-2.2	-1.4	-0.9	-1.5	-1.4	-1.5	-1.1	-2.5	-1.5	-1.3	-2.0	-2.2	0.3
Medication: Cholesterol lowering	1.2	1.9	3.8	1.3	1.8	1.9	1.3	0.2	1.7	0.8	1.6	1.2	1.4	1.2	1.5	1.0
Trunk predicted mass	1.2	7.0	32.8	-0.8	1.0	-3.4	-2.5	3.8	-4.0	0.7	-2.1	0.1	-1.2	0.6	-1.4	-5.7
Pulse rate, automated reading	1.2	4.0	14.0	1.1	-0.5	2.3	0.7	-2.3	3.5	-1.9	0.5	-0.6	0.3	-1.2	2.7	3.7
Leg fat-free mass (right)	1.2	6.4	22.8	-1.5	-0.3	-3.4	-3.2	2.8	-3.8	-0.8	-2.4	-0.8	-1.8	-0.5	-1.7	-4.8
Leg predicted mass (right)	1.2	6.4	23.1	-1.4	-0.2	-3.4	-3.2	2.8	-3.8	-0.8	-2.4	-0.8	-1.8	-0.5	-1.7	-4.8
Hair Pigment	1.1	29.9	62.9	-6.0	-7.7	-7.9	-5.9	-2.6	-7.0	-4.6	-1.8	-5.2	-6.6	-3.6	-5.7	-0.3
Relative age of first facial hair	1.1	2.2	5.2	-2.2	-1.6	-0.6	-1.2	-1.6	-1.2	-1.9	-0.7	-1.5	-1.0	-1.7	-2.3	1.2
Supplements: Zinc	1.1	1.1	3.7	0.9	0.6	0.3	1.3	1.4	-0.2	1.9	0.8	1.1	0.8	0.9	0.0	-1.8
Sitting height	1.1	8.2	40.3	-0.4	1.3	-4.1	-1.8	4.5	-4.3	0.9	0.3	0.6	-0.8	1.3	-1.2	-6.3
Illnesses of mother	1.1	1.4	4.3	1.3	0.7	1.3	1.5	0.4	1.3	0.5	2.1	0.9	1.1	0.9	1.2	1.0
Whole body fat-free mass	1.1	6.2	28.4	-0.9	0.7	-3.3	-2.6	3.4	-3.7	0.2	-2.0	-0.2	-1.3	0.3	-1.4	-5.3
Whole body water mass	1.1	6.2	28.8	-0.9	0.8	-3.2	-2.6	3.5	-3.7	0.2	-2.0	-0.1	-1.2	0.4	-1.4	-5.4
Myopia	1.1	1.6	4.5	1.0	0.7	1.8	1.8	1.1	0.9	2.1	1.0	1.2	1.0	1.1	0.5	-1.1
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	5.1	1.1	0.5	1.7	0.5	-0.9	2.2	-0.6	1.2	0.1	0.3	-0.1	1.7	1.5
Schizophrenia (2018)	1.0	2.0	7.1	0.8	0.8	1.6	2.5	0.4	0.5	2.7	1.5	1.6	1.3	1.3	-0.2	-0.5
Crohns Disease (2017)	1.0	2.1	4.1	1.8	1.8	0.8	0.8	1.4	1.3	0.8	1.8	1.5	1.7	1.7	2.0	-0.3
Vitamin and mineral supplements	1.0	1.4	5.9	0.4	0.4	0.9	-0.5	-1.1	1.5	-2.2	1.1	-0.3	0.2	-0.3	1.1	2.4
Maternal smoking around birth	1.0	1.4	5.5	1.7	1.0	0.8	1.0	-0.4	1.9	0.1	0.7	0.9	0.8	0.6	2.3	1.4
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	1.8	1.0	1.1	1.0	0.6	1.3	0.8	0.7	1.2	0.9	1.0	1.3	1.1	-0.8
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	3.7	0.9	0.8	-0.2	0.4	1.9	-0.4	0.8	1.1	1.4	1.1	1.3	0.3	-1.7
Medication: Simvastatin	1.0	1.5	2.5	1.5	1.6	1.1	1.2	0.6	1.3	0.8	1.4	1.2	1.1	1.3	1.6	0.3
Commuting to job workplace: Car/motor vehicle	1.0	1.1	5.9	0.7	-0.7	0.4	0.5	-1.3	1.0	-1.0	1.6	0.1	0.4	-0.2	1.0	2.4
Breast cancer (self-reported)	1.0	1.2	3.4	-0.1	-1.8	0.8	0.1	-1.4	1.0	-1.1	1.4	-1.0	-0.5	-1.1	1.0	1.5
Type 2 Diabetes (T2D) (2018)	0.9	1.6	4.8	1.2	1.5	-0.2	0.6	1.8	-0.6	2.0	-0.6	1.2	0.2	1.5	0.8	-2.2
Ever had hysterectomy (womb removed)	0.9	1.0	3.4	-0.6	0.3	-1.2	-1.4	0.9	-1.8	0.3	-0.3	-0.4	-0.9	0.0	-1.2	-1.8
Angina	0.9	1.2	2.6	0.6	1.6	1.5	0.7	1.2	0.4	1.6	-0.1	1.0	1.3	1.3	-0.1	-1.1
Severe depression (siblings)	0.9	1.0	2.4	1.1	1.5	0.9	1.0	0.5	0.9	1.2	1.2	1.0	1.2	0.9	1.0	0.0
Townsend deprivation index at recruitment	0.9	1.3	2.9	1.4	1.7	0.6	1.0	1.0	1.0	0.9	1.3	1.1	0.8	1.0	1.6	-0.6
High blood pressure (mother)	0.9	1.3	4.1	0.7	1.9	0.8	1.3	0.7	0.4	2.0	0.2	1.4	1.1	1.3	0.1	-0.9
Fluid intelligence score	0.9	1.8	3.4	-1.6	-1.6	-1.2	-1.2	-1.0	-1.7	-0.7	-0.9	-1.6	-1.6	-1.8	-1.4	-0.4
Illnesses of siblings	0.9	1.2	3.8	-1.2	-0.9	-1.2	-0.6	0.3	-1.9	0.7	-0.4	-0.7	-1.2	-0.5	-1.4	-1.9
Number of children fathered	0.9	1.0	2.9	1.7	0.6	0.3	1.1	1.2	0.6	0.6	0.7	1.3	0.9	1.0	1.3	-0.5
Angina (self-reported)	0.9	1.2	2.7	0.5	1.6	1.6	0.8	1.1	0.5	1.5	-0.2	1.0	1.3	1.2	-0.1	-1.0
Medication: Aspirin	0.9	1.1	2.7	1.1	1.6	1.4	0.6	0.9	0.9	0.6	0.8	1.5	1.4	1.2	0.5	-0.2
Alcohol drinker status: Never	0.9	1.1	2.0	-1.3	-1.3	-1.1	-0.8	-0.6	-1.3	-0.1	-1.1	-1.0	-1.1	-1.1	-1.4	-0.3
Basal metabolic rate	0.9	4.9	23.2	-0.6	0.8	-2.8	-2.4	3.2	-3.2	0.1	-1.7	-0.1	-1.1	0.4	-1.0	-4.8
Fractured/broken bones in last 5 years	0.9	1.1	2.1	1.4	0.9	1.2	1.2	0.5	1.5	0.5	0.9	1.2	1.3	0.8	1.2	0.4
Alzheimer’s Disease (in mother)	0.8	1.0	2.1	-1.2	-1.0	-1.1	-1.4	-0.1	-0.9	-1.0	-1.1	-1.0	-0.8	-1.0	-0.8	-0.7
Coronary Artery Disease (CAD)	0.8	0.9	1.9	-0.7	-1.2	-0.3	-1.0	-1.4	-0.1	-0.9	-0.9	-1.4	-1.4	-1.2	-0.0	0.6
HbA1C	0.8	0.9	2.9	1.0	0.9	0.9	0.6	-0.4	1.7	-0.1	0.8	0.4	0.5	0.3	1.6	1.2
Blood Eosinophil Count	0.8	6.2	21.5	2.2	0.0	3.3	1.6	-1.9	4.6	-1.9	-1.0	0.1	1.5	-0.4	3.7	4.1
Blood Platelet Count	0.8	9.5	23.0	-3.6	-2.1	-2.7	-2.1	-0.1	-4.0	1.8	-4.8	-2.2	-3.1	-1.8	-3.9	-4.2
Blood Red Count	0.8	7.7	28.2	2.7	1.1	1.0	-0.1	0.3	2.8	-3.7	5.3	1.5	2.4	1.1	3.9	3.9
Allergy or Eczema	0.8	2.1	6.1	-1.1	-0.6	-0.4	-2.5	0.3	-1.5	-2.0	-2.2	-1.4	-2.0	-1.1	-0.8	-1.1
Respiratory disease	0.8	1.7	2.8	-1.6	-1.6	-1.1	-0.9	-1.2	-1.3	-0.3	-1.5	-1.5	-1.7	-1.5	-1.5	0.1
Medication: Levothyroxine sodium	0.8	1.4	3.9	-1.4	-2.0	-0.6	-0.8	-1.0	-1.2	-0.6	-0.4	-1.4	-1.3	-1.5	-1.4	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	2.8	1.3	1.3	1.4	0.3	0.8	1.3	0.2	1.7	0.9	1.1	0.7	1.6	-0.5
Length of working week for main job	0.8	0.9	4.6	0.6	0.7	0.6	-0.7	1.8	-0.3	-0.2	0.4	0.5	-0.4	0.8	0.7	-2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	2.6	1.1	1.2	1.6	1.5	0.3	1.2	0.7	1.6	0.9	1.4	0.8	0.8	0.5
Blood clot in the leg (DVT)	0.8	1.0	3.8	1.0	0.5	1.4	0.4	-0.7	1.9	-0.5	1.1	0.1	0.1	-0.0	1.6	1.1
Qualifications: College or University degree	0.8	2.6	5.7	-2.4	-1.0	-0.6	-1.3	-2.0	-1.3	-0.6	-1.9	-1.9	-1.3	-2.2	-2.4	0.5
Age at last live birth	0.8	1.2	6.1	-1.4	-0.9	-0.7	-0.5	0.5	-1.7	0.3	-1.3	-0.1	-0.0	-0.4	-2.5	-1.1
Knee pain experienced in last month	0.8	1.3	4.8	1.3	0.8	1.1	1.1	-0.1	1.3	0.3	2.2	0.8	1.2	0.7	1.5	1.1
Illnesses of father: Heart disease	0.8	1.1	4.5	0.2	-0.2	0.4	-0.0	-1.3	1.3	-1.6	-1.2	-0.7	0.1	-0.8	1.1	2.1
Loneliness, isolation	0.8	1.1	3.8	1.0	0.9	1.9	0.7	-0.1	1.4	0.7	1.2	0.8	1.1	0.6	1.1	0.8
Ever had bowel cancer screening	0.8	0.9	5.7	-0.3	0.3	-0.4	-0.4	1.3	-1.3	0.8	-0.5	0.1	-0.6	0.5	-0.6	-2.4
Diabetes diagnosed by doctor	0.8	1.3	3.1	1.2	1.6	0.2	0.4	1.8	0.0	1.3	-0.7	1.1	0.6	1.4	0.9	-1.8
Commuting to job workplace: Public transport	0.8	1.0	6.4	-0.6	0.5	-0.7	-0.1	0.3	-0.8	1.1	-2.5	-0.2	-0.7	0.1	-0.7	-1.5
Medication: Lisinopril	0.8	1.0	3.9	0.3	1.3	0.5	0.4	1.3	-0.1	1.7	-0.0	1.0	0.6	1.2	-0.2	-2.0
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.5	1.2	1.6	0.4	0.3	1.4	0.6	0.3	0.3	1.0	0.9	1.1	1.4	-0.7
Diabetes (father)	0.7	0.9	2.7	0.4	0.9	1.7	0.8	-0.7	1.2	0.1	1.0	0.6	1.1	0.2	0.1	1.6
Hearing difficulty/problems with background noise	0.7	1.0	4.5	0.3	-1.1	0.5	0.2	-1.4	1.4	-1.2	-0.5	-0.6	-0.1	-0.7	1.1	2.1
Had other major operations	0.7	0.8	1.5	1.1	0.9	1.1	1.0	0.4	1.1	0.9	0.9	0.7	1.2	0.8	1.0	0.2
Allergy	0.7	1.7	4.9	0.7	0.6	0.7	2.2	0.0	0.7	1.8	2.0	1.5	1.9	1.1	0.0	0.7
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.3	-0.1	-0.4	1.3	0.3	-1.8	1.3	-0.1	-0.5	-0.8	-0.3	-0.9	0.5	1.7
Exposure to tobacco smoke outside home	0.7	1.0	2.0	0.6	1.0	1.3	0.9	1.1	0.1	1.3	1.4	1.1	1.0	1.1	-0.0	-0.9
Age at first live birth	0.7	1.2	4.4	-1.5	-1.0	0.4	-0.7	-0.4	-1.0	-0.6	-1.6	-0.9	-0.5	-1.2	-2.1	-0.1
Heart disease (mother)	0.7	0.9	2.2	-0.8	-1.1	-0.0	-0.6	-1.5	0.1	-1.2	-1.1	-1.1	-0.5	-1.4	-0.2	1.2
Family relationship satisfaction	0.7	0.9	3.0	-0.5	-0.6	-1.3	-1.3	1.3	-1.7	-0.3	0.3	0.0	-0.0	0.0	-0.7	-1.4
Mood swings	0.7	1.3	3.6	1.1	1.1	1.2	0.5	1.2	0.6	-0.1	1.9	1.4	1.7	1.0	0.8	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.3	-0.9	-1.1	-1.1	-0.2	-0.8	-1.0	-0.4	1.5	-0.5	-0.6	-1.0	-0.9	0.4
Arm fat-free mass (left)	0.7	3.7	20.8	-0.2	1.1	-2.1	-1.7	3.1	-2.4	0.6	-1.4	0.2	-0.8	0.7	-0.4	-4.6
Cholesterol lowering medication	0.7	1.0	1.9	1.3	1.4	0.9	0.6	0.7	0.8	0.4	1.2	1.1	1.3	1.2	0.9	0.4
Arm predicted mass (left)	0.7	3.6	20.8	-0.0	1.2	-1.9	-1.5	3.1	-2.3	0.8	-1.2	0.4	-0.6	0.8	-0.3	-4.6
Worry (Nagel 2018)	0.6	1.3	3.9	-1.7	-0.5	-0.7	-1.1	-0.1	-1.8	0.4	-1.1	-1.1	-0.9	-0.7	-2.0	-1.4
Alzheimer’s Disease (including proxy)	0.6	0.8	1.7	-1.1	-0.7	-0.8	-1.3	-0.5	-0.6	-0.6	-1.0	-1.3	-1.2	-1.1	-0.2	-0.6
Bipolar Disorder (2011)	0.6	0.6	2.3	-0.1	0.0	-0.7	0.1	0.8	-1.0	1.0	-1.1	0.3	0.1	0.2	-0.9	-1.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.4	1.2	0.5	1.2	1.1	0.1	1.1	0.3	0.4	0.7	0.9	0.7	0.9	0.8
Medication: Co-codamol	0.6	0.7	2.7	1.0	0.8	0.3	0.9	0.1	1.2	0.0	1.2	0.5	0.5	0.4	1.7	0.4
Fed-up feelings	0.6	1.1	2.4	1.4	1.1	0.9	0.6	1.4	0.7	0.3	1.0	1.6	1.2	1.1	0.9	-0.6
Relative age voice broke	0.6	0.9	2.0	-1.4	-1.1	-1.2	-0.9	-0.4	-1.1	-0.9	-0.3	-1.1	-0.9	-0.9	-1.3	-0.3
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.9	-0.3	-0.1	-0.5	-2.0	0.6	-0.9	-1.4	-1.9	-1.0	-1.7	-0.5	0.1	-1.2
Depression (self-reported)	0.6	0.8	1.6	1.1	1.0	0.4	1.3	0.3	0.8	1.0	0.8	0.9	1.2	0.9	0.9	0.2
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.0	0.5	1.0	0.4	1.1	0.9	-0.0	1.0	1.4	1.0	0.8	0.8	0.2	-0.5
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	5.1	-0.5	0.3	-0.4	-0.7	0.8	-1.3	0.8	-1.5	-0.6	-1.0	-0.1	-0.4	-2.3
Alcohol intake frequency.	0.6	1.4	5.2	-0.6	-2.3	-0.6	-0.4	-1.4	-0.4	-0.9	-1.0	-1.6	-1.7	-1.5	-0.2	0.6
Supplements: Vitamin C	0.6	0.7	3.0	0.1	-0.3	-0.0	0.9	1.0	-1.0	1.6	0.1	0.6	0.3	0.4	-0.9	-1.7
Friendships satisfaction	0.6	0.8	2.8	-0.8	-0.4	-0.4	-1.0	0.9	-1.7	-0.0	0.9	-0.0	-0.6	-0.2	-1.2	-1.5
Eye problems/disorders: Cataract	0.6	0.7	2.3	0.5	-0.7	1.5	0.9	-1.1	1.1	-0.4	-0.3	-0.3	-0.1	-0.5	0.7	1.5
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	3.1	0.8	1.6	0.2	0.9	0.9	-0.4	1.8	0.3	0.9	0.4	1.2	0.2	-1.1
Medication: Bendroflumethiazide	0.6	0.9	3.0	0.2	1.7	0.2	0.1	1.6	-0.7	0.9	0.2	1.1	0.8	1.2	-0.2	-1.4
Number of operations (self-reported)	0.6	1.0	2.3	1.3	1.1	1.1	0.2	0.8	1.1	-0.0	1.1	1.1	1.5	0.8	1.0	0.3
Average weekly beer plus cider intake	0.6	0.8	3.9	0.4	1.3	0.2	0.8	0.7	-0.3	2.0	0.3	0.9	0.7	1.2	-0.1	-0.6
Risk taking	0.6	0.8	1.5	1.1	1.1	0.3	0.5	1.2	0.7	0.5	0.5	1.0	1.0	1.2	1.1	-0.6
Ovarian Cancer	0.5	0.6	1.6	-0.6	-0.8	-0.6	-1.0	-0.6	-0.9	-1.1	-0.0	-1.0	-1.3	-0.7	-0.2	-0.0
Body Mass Index (BMI) (2010)	0.5	0.7	2.5	-0.5	-0.4	-1.6	-0.8	0.7	-1.2	-0.3	-1.1	0.1	0.1	-0.2	-1.1	-0.7
Fasting Glucose	0.5	0.6	1.6	-1.1	-0.1	-1.1	-0.7	-0.4	-1.3	0.4	-0.7	-0.7	-0.7	-0.5	-1.2	-0.3
Schizophrenia (2014)	0.5	1.1	5.2	0.5	0.6	1.0	1.9	-0.0	0.8	2.3	0.6	1.1	1.0	0.8	0.0	-0.3
Blood White Count	0.5	3.8	10.8	1.1	1.0	3.3	1.6	-1.3	3.0	-0.5	2.6	0.6	1.6	0.1	1.9	3.1
Lung FEV1/FVC ratio	0.5	2.4	17.6	1.5	-0.7	-0.6	0.5	-0.2	0.5	-1.8	4.2	0.5	0.5	0.5	1.2	2.2
Current tobacco smoking	0.5	0.8	4.8	1.1	0.4	-0.3	0.8	0.7	0.6	0.5	2.2	0.8	0.5	0.8	1.1	-0.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	-0.5	-0.6	0.6	-0.8	-1.0	0.3	-1.1	0.1	-0.8	-0.4	-1.0	-0.4	1.1
Number of incorrect matches in round	0.5	0.8	3.5	0.2	0.7	-0.7	0.2	1.2	-0.6	1.3	-0.6	0.8	-0.1	0.9	-0.4	-1.9
Diabetes (self-reported)	0.5	0.8	1.7	0.9	1.1	-0.0	0.2	1.0	-0.0	1.2	-1.2	0.6	0.0	1.0	0.9	-1.3
Number of live births	0.5	0.7	1.8	0.7	1.0	0.3	0.5	1.2	0.1	0.5	0.8	1.3	1.1	1.4	0.5	-0.4
Asthma	0.5	0.9	2.0	-0.9	-1.1	-0.3	-0.7	-1.3	0.1	-0.9	-1.2	-1.2	-0.9	-1.4	-0.6	0.9
Peak expiratory flow (PEF)	0.5	1.1	3.2	-1.0	-1.5	-1.8	-1.1	-0.6	-1.3	-1.2	0.2	-1.0	-1.1	-1.0	-0.8	0.0
Arm fat-free mass (right)	0.5	2.7	15.6	-0.0	1.2	-1.5	-1.4	2.8	-2.0	0.5	-0.9	0.3	-0.4	0.7	-0.1	-4.0
Wheeze or whistling in the chest in last year	0.5	0.9	2.2	1.2	1.4	1.5	0.5	0.6	1.1	0.2	0.7	0.8	1.1	0.7	1.1	0.2
Suffer from ‘nerves’	0.5	0.8	3.5	-0.8	0.5	-0.1	-0.4	0.4	-1.3	1.6	-0.3	-0.4	-0.3	0.1	-1.0	-1.9
Medication: Aspirin	0.5	0.6	1.7	0.6	1.3	1.1	0.4	0.7	0.6	0.4	0.4	1.1	1.1	0.9	0.1	-0.1
Depressed Affect (Nagel 2018)	0.4	0.9	2.6	0.9	0.8	0.5	0.1	1.5	-0.1	0.5	1.6	1.3	1.0	1.0	0.3	-1.1
Schizophrenia vs Biploar Disorder	0.4	0.5	1.6	-0.8	-0.3	-0.8	0.1	-0.5	-0.8	1.0	0.0	-0.4	-0.7	-0.4	-1.3	-1.0
LDL Cholesterol	0.4	0.6	1.7	0.6	-0.1	0.8	1.1	-0.3	1.0	0.3	1.3	0.4	1.1	0.6	0.7	1.1
Lupus	0.4	0.7	1.6	-1.1	-0.5	-0.6	-0.5	-0.9	-0.9	0.3	-1.3	-0.8	-0.9	-0.5	-1.1	0.4
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.0	-0.8	-0.5	-0.6	-1.0	-0.6	-1.0	-0.4	-0.4	-0.6	-0.7	-0.6	-0.9	-0.3
Medication: Metformin	0.4	0.6	1.4	0.8	0.7	0.7	0.5	0.9	0.3	1.2	-0.0	0.9	0.4	0.9	0.5	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.2	0.8	0.9	1.3	1.1	-0.2	1.5	0.3	0.1	0.6	1.3	0.7	0.8	1.2
Weight	0.4	1.9	9.3	0.3	0.9	-1.4	-1.6	2.4	-1.6	-0.4	-0.9	0.1	-0.6	0.5	0.3	-3.1
Alcohol intake versus 10 years previously	0.4	0.6	2.7	-0.1	-0.8	0.2	-1.0	-0.5	0.4	-1.6	-0.4	-0.9	-0.6	-0.7	0.7	0.5
Tense / ‘highly strung’	0.4	0.6	1.9	0.6	0.7	1.4	0.9	0.7	0.7	0.7	-0.1	0.8	0.8	0.9	0.6	-0.4
Worry too long after embarrassment	0.4	0.6	1.8	0.4	-0.1	0.8	1.2	-1.2	0.9	0.6	1.1	-0.0	0.4	-0.1	0.5	1.3
Medication: Seretide 50 evohaler	0.4	0.4	1.6	-0.2	-0.1	0.7	-0.2	-0.7	0.7	-1.2	-0.3	-0.4	0.3	-0.7	0.1	1.3
Arm predicted mass (right)	0.4	2.3	13.3	0.1	1.2	-1.4	-1.4	2.6	-1.7	0.3	-0.7	0.3	-0.4	0.6	0.0	-3.7
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.5	-0.3	-0.3	-0.9	-0.6	0.6	-1.0	-0.4	-1.2	-0.2	-0.5	-0.0	-0.5	-1.2
Asthma (self-reported)	0.4	0.8	2.0	-1.0	-1.0	-0.3	-0.6	-1.3	-0.0	-0.5	-1.4	-1.1	-0.9	-1.3	-0.7	0.6
Medication: Gliclazide	0.4	0.5	1.1	1.1	0.9	0.8	0.4	0.1	0.9	0.6	0.4	0.6	0.3	0.5	1.1	-0.0
Ever taken oral contraceptive pill	0.4	0.4	1.3	-0.6	0.8	-0.3	-0.8	0.6	-1.1	0.1	0.0	0.3	-0.3	0.1	-1.1	-1.0
Age started oral contraceptive pill	0.4	0.5	1.7	-0.8	0.3	0.1	0.0	-0.3	-0.8	0.9	-1.2	-0.3	-0.5	-0.1	-1.3	-0.6
Commuting to job workplace: Cycle	0.4	0.5	1.4	0.3	0.8	0.0	0.9	0.7	0.5	1.1	-0.0	0.9	1.2	0.6	0.3	-0.5
Bipolar Disorder (2018)	0.3	0.5	1.2	-0.1	-0.7	-0.2	-0.5	-0.9	0.8	-0.8	-1.1	-0.7	-0.3	-0.9	0.8	0.9
Bipolar Disorder or Schizophrenia	0.3	0.7	2.7	0.5	0.2	1.0	1.6	-0.3	0.9	1.6	0.5	0.8	0.8	0.4	0.3	0.2
Mean Putamen Volume	0.3	0.4	1.7	0.9	0.3	0.4	0.3	-0.4	0.6	0.0	1.0	-0.0	-0.0	0.0	1.3	0.5
Rheumatoid Arthritis	0.3	0.4	1.1	0.0	-0.2	0.5	0.9	-1.0	1.1	0.8	-0.6	-0.2	0.4	-0.5	0.2	0.4
Neuroticism	0.3	0.7	1.9	-0.9	-0.6	-1.0	-1.0	-0.0	-1.4	-0.1	-0.1	-0.5	-0.8	-0.7	-1.2	-0.9
Chronotype (morning person)	0.3	0.7	4.6	-0.5	-0.8	-0.0	-0.2	-1.1	0.6	-0.5	-2.1	-0.8	-0.5	-0.5	-0.0	0.7
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.9	-0.3	0.8	0.5	-0.7	-0.7	0.4	-0.9	0.3	-0.5	0.2	-0.4	0.2	0.9
Prospective memory result	0.3	0.3	1.2	-0.5	-0.6	-1.1	-0.5	-0.0	-0.2	-0.6	-1.1	-0.4	0.2	-0.3	-0.4	0.1
Body fat percentage	0.3	1.1	3.7	1.2	0.7	1.2	0.1	-0.3	1.6	-1.4	0.8	0.1	0.4	0.1	1.9	1.4
Migraine (self-reported)	0.3	0.4	1.6	0.5	-0.0	0.7	1.2	-0.2	0.8	0.6	1.3	0.6	0.1	0.2	0.5	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.1	0.3	0.4	0.1	-1.1	0.8	-0.3	-0.8	-0.7	-0.2	-0.8	0.1	0.6	-0.9
Number of full sisters	0.3	0.4	1.0	-0.5	-1.0	-0.7	-0.5	-0.4	-0.7	-0.4	0.6	-0.3	-0.1	-0.8	-0.8	0.2
Arm fat percentage (left)	0.3	1.3	6.7	0.3	-0.2	0.6	-1.1	-0.8	1.1	-2.6	-0.4	-0.7	-0.1	-0.9	1.2	1.8
Qualifications: nursing, teaching	0.3	0.5	2.1	-0.7	-0.2	1.5	0.0	-1.0	0.4	-0.2	0.7	-0.4	0.1	-0.8	-0.7	0.7
Commuting to job workplace: Walk	0.3	0.3	1.5	-0.1	-0.3	-1.2	-0.0	0.4	-0.6	0.3	-0.7	-0.2	-0.7	-0.1	-0.2	-0.6
Osteoporosis (self-reported)	0.3	0.3	1.2	0.6	0.3	0.1	0.8	0.3	0.8	0.2	-0.1	0.7	1.1	0.3	0.8	0.5
Smoking status: Current	0.3	0.4	3.5	0.6	-0.0	-0.8	0.4	0.3	0.3	0.1	1.9	0.3	0.1	0.3	0.8	0.1
Tinnitus: Yes, now most or all of the time	0.3	0.4	2.6	-0.4	-0.5	-0.7	-0.6	0.4	-0.8	-0.3	-1.6	-0.2	-0.1	-0.2	-0.6	-0.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.3	0.1	1.2	-0.3	0.6	0.7	-0.2	1.1	0.5	0.5	0.4	0.7	0.2	-0.9
Heart disease (siblings)	0.3	0.4	2.0	-0.2	-0.2	0.5	0.0	-0.8	1.0	-0.2	-1.4	-0.2	0.1	-0.2	0.2	1.2
Impedance of whole body	0.3	1.5	4.9	0.6	0.1	1.0	1.9	-1.6	1.4	0.7	2.2	0.2	0.1	0.4	0.8	2.0
Neuroticism (Nagel 2018)	0.2	0.5	2.0	0.2	0.6	0.7	0.1	0.9	-0.2	0.6	1.4	0.6	0.7	0.6	-0.2	-1.1
Alzheimer’s Disease (in father)	0.2	0.3	1.6	0.0	0.5	-0.1	0.4	-0.5	0.3	1.2	-0.1	-0.2	-0.6	-0.1	0.5	-0.6
Breast Cancer	0.2	0.6	2.4	0.5	0.8	0.7	0.4	0.7	0.1	1.0	-1.6	0.4	0.5	0.6	0.3	-1.0
Primary Biliary Cirrhosis	0.2	0.3	1.0	-0.2	0.4	-1.0	0.0	0.1	-0.7	0.9	-1.0	-0.1	-0.3	-0.2	-0.4	-0.9
Average weekly spirits intake	0.2	0.2	0.8	0.5	0.4	-0.6	-0.3	0.9	-0.3	0.0	0.2	0.5	0.5	0.3	0.3	-0.7
Medication for hormone replacement therapy	0.2	0.2	1.1	0.3	1.1	-0.0	-0.7	0.3	0.1	0.0	0.6	0.1	0.3	0.3	0.8	-0.1
Diabetes (mother)	0.2	0.2	1.2	-0.1	0.1	-0.5	-0.0	0.1	-0.3	0.6	-1.1	-0.0	-0.5	-0.0	-0.4	-0.7
Trunk fat percentage	0.2	0.7	2.7	0.9	0.5	0.8	-0.1	-0.2	1.2	-1.4	0.5	-0.1	0.1	0.0	1.6	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	0.7	0.6	0.6	-0.0	0.4	0.8	-0.4	0.1	0.4	0.8	0.1	0.6	0.1
Body mass index (BMI)	0.2	0.7	2.2	0.9	0.6	1.1	-0.5	0.2	1.2	-1.3	0.1	0.1	0.6	-0.0	1.5	0.7
Waist circumference	0.2	0.7	2.3	0.6	1.2	-0.4	-1.1	1.5	-0.5	-0.5	-0.1	0.4	0.0	0.5	0.6	-1.4
Nervous feelings	0.2	0.4	1.3	-0.8	-0.1	0.5	0.2	-0.5	-0.6	1.2	0.4	-0.5	-0.4	-0.3	-0.9	-0.6
Impedance of arm (right)	0.2	0.8	3.2	-0.8	-0.8	-1.8	-0.4	-0.6	-1.2	-0.4	-0.4	-0.8	-1.5	-0.4	-0.8	0.0
Arm fat percentage (right)	0.2	0.7	4.7	0.2	-0.0	0.0	-1.2	-0.2	0.5	-2.2	-0.7	-0.6	-0.3	-0.6	0.9	0.9
Hip circumference	0.2	0.7	3.0	0.5	1.1	0.0	-0.6	1.7	-0.3	-0.2	-0.3	0.5	0.3	0.6	0.5	-1.7
Time employed in main current job	0.2	0.2	0.5	0.6	0.5	0.0	0.6	0.1	0.5	0.1	-0.6	0.7	0.5	0.4	0.2	0.5
Impedance of arm (left)	0.2	0.9	3.0	-0.7	-1.1	-0.7	-0.1	-1.6	-0.1	-1.1	0.3	-0.9	-1.0	-0.8	-0.4	1.7
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.9	0.3	-0.4	0.4	-0.0	-0.7	0.9	-0.8	-0.2	-0.4	-0.2	-0.4	0.9	0.8
Glaucoma (self-reported)	0.2	0.2	1.0	0.1	0.5	-0.3	0.8	0.2	-0.4	1.0	-0.3	0.3	0.2	0.4	-0.2	-0.2
High blood pressure (siblings)	0.2	0.3	1.4	-0.4	-0.2	0.1	-0.6	-0.5	0.2	-1.2	-0.7	-0.4	-0.0	-0.8	-0.3	0.8
Leg fat mass (right)	0.2	0.8	2.6	1.3	1.4	1.0	0.1	0.7	1.1	-0.4	0.3	0.7	0.8	0.7	1.6	0.0
Illnesses of siblings: Diabetes	0.2	0.2	0.5	0.5	0.3	0.4	0.7	0.3	0.3	0.6	0.4	0.5	0.5	0.7	0.0	0.2
Miserableness	0.2	0.4	3.0	0.7	-0.1	0.3	0.3	0.7	-0.2	0.3	1.7	0.6	0.5	0.4	0.4	-0.5
Irritability	0.2	0.4	1.1	-0.3	0.0	-0.4	-0.6	0.9	-0.8	-0.6	-0.3	0.4	0.6	-0.0	-1.1	-0.5
Diastolic blood pressure, automated reading	0.2	0.7	2.8	0.6	0.5	1.3	0.4	-0.5	1.7	-0.5	1.1	0.2	0.4	-0.3	1.4	0.8
Leg fat mass (left)	0.2	0.7	2.2	1.1	1.3	1.1	0.0	0.6	1.1	-0.5	0.4	0.5	0.7	0.5	1.5	0.0
Depression (Nagel 2018)	0.1	0.2	0.9	0.1	0.5	-0.0	-0.2	1.0	-0.2	-0.1	0.5	0.3	0.3	0.2	-0.0	-1.0
Triglycerides	0.1	0.1	0.7	0.3	-0.5	-0.8	-0.1	-0.1	-0.0	0.2	-0.3	-0.3	-0.0	-0.1	0.7	0.0
Heel T-Score	0.1	1.1	3.3	1.5	0.5	0.4	1.1	-0.2	1.8	0.1	-0.4	0.8	1.1	0.8	1.6	1.4
BMI	0.1	0.3	1.2	0.5	0.7	0.3	-0.6	1.1	0.1	-0.6	-0.4	0.3	0.4	0.2	0.6	-0.6
Waist Hip Ratio (WHR)	0.1	0.5	1.4	-0.6	0.0	-1.0	-0.8	-0.1	-1.2	0.2	0.5	-0.5	-1.0	-0.3	-0.9	-0.9
Sensitivity / hurt feelings	0.1	0.2	0.5	-0.2	0.3	0.0	0.1	0.3	-0.4	0.7	0.5	0.3	0.2	0.4	-0.4	-0.6
Age when periods started (menarche)	0.1	0.2	0.6	0.0	-0.6	-0.2	0.2	-0.5	-0.1	0.1	-0.8	0.0	0.0	0.1	-0.2	0.8
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.5	-0.2	0.3	-0.2	-0.5	-0.3	-0.0	-0.5	-0.2	-0.7	-0.4	-0.3	0.2	0.3
Trunk fat mass	0.1	0.4	1.4	0.6	0.7	-0.2	-0.8	0.7	0.0	-1.2	-0.2	-0.1	-0.3	0.1	1.1	-0.5
Neuroticism score	0.1	0.1	0.7	-0.1	0.0	0.1	-0.0	0.2	-0.5	0.5	0.8	0.3	0.3	0.0	-0.4	-0.5
Worrier / anxious feelings	0.1	0.3	0.8	-0.6	-0.0	0.6	0.1	-0.9	0.1	-0.1	-0.3	-0.4	0.2	-0.7	-0.8	0.7
Arm fat mass (right)	0.1	0.5	1.6	0.4	0.6	-0.2	-1.2	0.8	-0.0	-1.3	-0.6	-0.2	-0.3	-0.0	1.0	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	0.0	-0.4	-0.4	0.1	0.0	-0.0	0.0	-0.6	-0.2	-0.1	-0.3	-0.0	-0.2
Eye problems/disorders: None of the above	0.1	0.2	0.9	-0.4	-0.1	-0.8	-0.6	0.1	-0.4	-0.0	0.9	-0.1	-0.2	-0.2	-0.1	-0.2
Emphysema/chronic bronchitis	0.1	0.1	0.5	0.2	0.2	0.3	0.2	-0.1	0.3	-0.1	-0.7	0.0	0.1	-0.1	0.2	0.4
Whole body fat mass	0.1	0.4	1.8	0.8	0.8	0.2	-0.6	0.8	0.4	-1.0	0.1	0.1	0.0	0.3	1.3	-0.4
Chest pain or discomfort	0.1	0.2	0.6	-0.5	-0.1	0.5	-0.1	-0.4	0.1	-0.0	-0.8	-0.4	0.3	-0.7	-0.8	0.2
Arm fat mass (left)	0.1	0.5	2.4	0.3	0.6	0.1	-1.2	0.6	0.1	-1.6	-0.5	-0.3	-0.2	-0.2	0.9	-0.3
Eye problems/disorders: Glaucoma	0.1	0.1	0.5	-0.0	-0.0	-0.5	0.7	-0.3	-0.2	0.5	-0.6	-0.1	-0.2	-0.0	-0.2	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.8	-0.1	-0.0	-0.3	0.3	-0.3	0.2	0.3	-0.9	-0.1	0.1	-0.0	-0.1	0.3

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