Hub : Traits :

Hair/balding pattern: Pattern 2

120 significantly associated models · 37 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 169191860 171407761 2 1 2.0e-09 1.7e-14 5.1e-13 11 PRRX1
2 2 222365938 224121118 2 3 1.1e-50 6.3e-75 5.1e-27 66 PAX3 SGPP2
3 4 14217009 16125136 3 1 6.0e-11 6.2e-11 2.9e-02 89 CPEB2
4 4 80488345 82578407 2 1 2.3e-12 1.9e-12 1.0e+00 100 C4orf22
5 7 18364750 19854141 1 1 1.4e-11 7.6e-18 6.4e-08 60 TWIST1
6 7 148480233 150009838 2 1 7.4e-08 7.8e-08 3.0e-01 96 ZNF746
7 10 31857752 33353843 1 1 1.4e-08 5.2e-10 6.6e-03 81 EPC1
8 10 76664253 79018276 1 1 7.7e-08 3.7e-09 1.2e-02 82 C10orf11
9 13 100044673 101879559 1 1 1.3e-08 7.2e-11 7.4e-06 53 PCCA
10 15 56030756 58298129 2 2 2.3e-10 8.1e-09 2.5e-01 96 LINC00926 MNS1
11 17 42607368 43913030 6 1 8.7e-10 1.4e-06 1.7e-02 76 KIAA1267
12 17 44788310 45796313 5 1 5.1e-10 7.6e-10 1.0e+00 100 LRRC37A2
13 17 62973790 64251733 1 1 1.8e-12 1.0e-12 1.0e+00 100 AXIN2
14 20 21043102 22430527 1 1 4.2e-12 1.6e-25 2.7e-15 43 RPL41P1
15 20 30591354 32083711 2 1 3.6e-08 1.9e-07 7.2e-01 100 COMMD7

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Reaction Time 1.49 1 0 0.0 0.00 1.0000 COMMD7
Breast Cancer 1.92 2 1 3.0 0.00 1.0000 KIAA1267 LRRC37A2
Ovarian Cancer 4.41 2 2 6.1 0.00 1.0000 KIAA1267 LRRC37A2
Crohns Disease (2012) 2.05 1 0 0.0 0.00 1.0000 ZNF746
Mean Putamen Volume 2.11 2 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2
Neuroticism 2.04 2 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2
Primary Biliary Cirrhosis 1.91 2 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2
Schizophrenia 0.96 1 0 0.0 0.00 1.0000 LRRC37A2
Blood Eosinophil Count 2.17 2 2 6.1 0.00 1.0000 KIAA1267 LRRC37A2
Blood Platelet Count 0.58 5 1 3.0 -0.70 0.1838 COMMD7 CPEB2 KIAA1267 LINC00926 LRRC37A2
Blood Red Count 5.38 3 2 6.1 0.00 1.0000 C4orf22 KIAA1267 LRRC37A2
Blood White Count 0.60 3 0 0.0 0.00 1.0000 EPC1 KIAA1267 LRRC37A2
Heel T-Score 2.34 5 4 12.1 0.49 0.4021 CPEB2 KIAA1267 LRRC37A2 PRRX1 TWIST1
BMI 0.55 1 0 0.0 0.00 1.0000 C4orf22
Height 1.05 8 3 9.1 0.34 0.4081 AXIN2 C10orf11 EPC1 KIAA1267 LRRC37A2 PAX3 RPL41P1 ZNF746
Waist Hip Ratio (WHR) 5.08 6 5 15.2 0.20 0.6998 AXIN2 EPC1 KIAA1267 LRRC37A2 MNS1 PRRX1
Systolic Blood Pressure 3.23 5 2 6.1 0.96 0.0097 C4orf22 COMMD7 CPEB2 KIAA1267 LRRC37A2
Smoking Status 1.75 3 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2 PCCA
Cardiovascular Disease 2.49 2 1 3.0 0.00 1.0000 C4orf22 CPEB2
Respiratory disease 1.26 1 0 0.0 0.00 1.0000 EPC1
Lung FEV1/FVC ratio 1.42 3 1 3.0 0.00 1.0000 C10orf11 KIAA1267 LRRC37A2
Lung FVC 6.37 6 4 12.1 0.32 0.5399 C10orf11 COMMD7 EPC1 KIAA1267 LRRC37A2 TWIST1
Neuroticism 5.06 2 2 6.1 0.00 1.0000 KIAA1267 LRRC37A2
Hair Pigment 0.80 10 6 18.2 0.23 0.5146 AXIN2 C4orf22 COMMD7 EPC1 KIAA1267 LRRC37A2 PAX3 RPL41P1 SGPP2 TWIST1
Tanning 0.47 2 1 3.0 0.00 1.0000 COMMD7 KIAA1267
Hand grip strength (left) 3.19 4 2 6.1 0.01 0.9894 KIAA1267 LINC00926 LRRC37A2 MNS1
Number of treatments/medications taken 1.46 1 0 0.0 0.00 1.0000 COMMD7
Sensitivity / hurt feelings 5.12 2 2 6.1 0.00 1.0000 KIAA1267 LRRC37A2
Frequency of depressed mood in last 2 weeks 1.75 2 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2
Relative age of first facial hair 8.37 5 4 12.1 0.98 0.0046 C4orf22 KIAA1267 LRRC37A2 SGPP2 TWIST1
Systolic blood pressure, automated reading 2.90 4 1 3.0 -0.99 0.0059 C4orf22 CPEB2 KIAA1267 LRRC37A2
Vitamin and mineral supplements 2.13 2 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2
Impedance of leg (right) 0.69 2 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2
Trunk fat percentage 1.39 3 2 6.1 0.00 1.0000 KIAA1267 LRRC37A2 PRRX1
Hand grip strength (right) 2.46 3 2 6.1 0.00 1.0000 KIAA1267 LRRC37A2 MNS1
Fed-up feelings 2.69 2 2 6.1 0.00 1.0000 KIAA1267 LRRC37A2
Relative age voice broke 4.84 2 2 6.1 0.00 1.0000 KIAA1267 LRRC37A2
Qualifications: CSEs or equivalent 2.73 2 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2
Serious illness, injury or assault to yourself 1.18 1 0 0.0 0.00 1.0000 COMMD7
High blood pressure 2.87 3 1 3.0 0.00 1.0000 C4orf22 KIAA1267 LRRC37A2
Medication: Atenolol 1.43 1 0 0.0 0.00 1.0000 C4orf22
Sitting height 2.05 4 2 6.1 -0.16 0.8399 KIAA1267 LRRC37A2 TWIST1 ZNF746
High blood pressure (mother) 1.51 1 0 0.0 0.00 1.0000 C4orf22
Impedance of leg (left) 0.78 2 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2
Trunk fat mass 0.93 2 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2
Past tobacco smoking 1.99 2 0 0.0 0.00 1.0000 COMMD7 PCCA
Alcohol usually taken with meals 1.94 1 0 0.0 0.00 1.0000 COMMD7
Nervous feelings 3.04 2 2 6.1 0.00 1.0000 KIAA1267 LRRC37A2
Frequency of tenseness / restlessness in last 2 weeks 3.52 2 2 6.1 0.00 1.0000 KIAA1267 LRRC37A2
Hearing difficulty/problems with background noise 1.65 2 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2
Forced vital capacity (FVC) 5.01 4 3 9.1 -0.78 0.2202 C10orf11 KIAA1267 LRRC37A2 TWIST1
Ever unenthusiastic/disinterested for a whole week 2.37 2 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2
Qualifications: None of the above 1.57 1 0 0.0 0.00 1.0000 LINC00926
Neuroticism score 4.36 2 2 6.1 0.00 1.0000 KIAA1267 LRRC37A2
Impedance of arm (right) 1.64 3 2 6.1 0.00 1.0000 KIAA1267 LRRC37A2 MNS1
Arm fat percentage (right) 0.63 1 0 0.0 0.00 1.0000 PRRX1
Hip circumference 0.86 1 0 0.0 0.00 1.0000 PRRX1
Time employed in main current job 3.02 2 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2
Worrier / anxious feelings 2.42 2 2 6.1 0.00 1.0000 KIAA1267 LRRC37A2
Hair/balding pattern: Pattern 3 22.77 8 6 18.2 -0.84 0.0086 C4orf22 KIAA1267 LRRC37A2 PAX3 PCCA PRRX1 RPL41P1 TWIST1
Number of live births 2.30 2 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2
Forced expiratory volume in 1-second (FEV1) 5.76 3 3 9.1 0.00 1.0000 C10orf11 KIAA1267 LRRC37A2
Asthma 0.79 1 0 0.0 0.00 1.0000 EPC1
Medication: Ibuprofen (e.g. Nurofen) 2.42 2 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2
Forced expiratory volume in 1-second (FEV1), Best measure 5.44 5 3 9.1 -0.22 0.7225 C10orf11 KIAA1267 LRRC37A2 TWIST1 ZNF746
Impedance of arm (left) 1.91 4 2 6.1 -0.75 0.2538 KIAA1267 LRRC37A2 MNS1 RPL41P1
Standing height 0.76 2 2 6.1 0.00 1.0000 KIAA1267 LRRC37A2
Breastfed as a baby 1.31 1 0 0.0 0.00 1.0000 LINC00926
Hair/balding pattern: Pattern 4 32.25 9 8 24.2 -0.75 0.0203 C10orf11 C4orf22 CPEB2 EPC1 KIAA1267 LRRC37A2 PRRX1 RPL41P1 TWIST1
Birth weight of first child 1.76 1 0 0.0 0.00 1.0000 LINC00926
Peak expiratory flow (PEF) 3.78 3 2 6.1 0.00 1.0000 C10orf11 KIAA1267 LRRC37A2
Medication: Paracetamol 4.34 3 2 6.1 0.00 1.0000 COMMD7 KIAA1267 LRRC37A2
Headache pain in last month 4.44 2 2 6.1 0.00 1.0000 KIAA1267 LRRC37A2
Medication for cholesterol, blood pressure or diabetes 1.69 1 0 0.0 0.00 1.0000 C4orf22
High blood pressure (siblings) 1.98 1 0 0.0 0.00 1.0000 C4orf22
Forced vital capacity (FVC), Best measure 5.24 5 3 9.1 -0.18 0.7663 C10orf11 KIAA1267 LRRC37A2 TWIST1 ZNF746
Body fat percentage 1.01 4 0 0.0 0.29 0.7076 C4orf22 KIAA1267 LRRC37A2 PRRX1
Leg fat percentage (right) 0.85 1 0 0.0 0.00 1.0000 PRRX1
Number of full brothers 1.76 2 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2
Worry too long after embarrassment 1.65 2 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2
Wheeze or whistling in the chest in last year 1.84 1 0 0.0 0.00 1.0000 C10orf11
Age at first live birth 1.68 2 0 0.0 0.00 1.0000 C10orf11 LRRC37A2
Pulse wave peak to peak time 1.46 1 0 0.0 0.00 1.0000 COMMD7
Qualifications: College or University degree 2.63 3 2 6.1 0.00 1.0000 KIAA1267 LRRC37A2 PCCA
Medication for pain relief, constipation, heartburn 3.05 3 1 3.0 0.00 1.0000 COMMD7 KIAA1267 LRRC37A2
Neck or shoulder pain in last month 1.55 1 0 0.0 0.00 1.0000 COMMD7
Medication: Blood pressure 1.81 1 1 3.0 0.00 1.0000 C4orf22
Pulse rate, automated reading 0.80 1 0 0.0 0.00 1.0000 C4orf22
Alcohol intake frequency. 2.46 2 2 6.1 0.00 1.0000 KIAA1267 LRRC37A2
Comparative height size at age 10 1.05 3 2 6.1 0.00 1.0000 C4orf22 KIAA1267 LRRC37A2
Overall health rating 1.17 1 0 0.0 0.00 1.0000 COMMD7
Supplements: Vitamin C 2.29 2 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2
Hypertension (Self-reported) 2.85 2 1 3.0 0.00 1.0000 C4orf22 KIAA1267
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.63 1 0 0.0 0.00 1.0000 C10orf11
Smoking status: Previous 2.36 2 0 0.0 0.00 1.0000 COMMD7 PCCA
Arm fat percentage (left) 0.70 1 0 0.0 0.00 1.0000 PRRX1
Handedness (chirality/laterality): Left-handed 3.67 2 2 6.1 0.00 1.0000 KIAA1267 LRRC37A2
Mood swings 4.09 2 2 6.1 0.00 1.0000 KIAA1267 LRRC37A2
Loneliness, isolation 2.08 2 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2
Long-standing illness, disability or infirmity 1.47 1 0 0.0 0.00 1.0000 COMMD7
Mouth/teeth dental problems: Mouth ulcers 3.30 2 2 6.1 0.00 1.0000 KIAA1267 LRRC37A2
Medication for cholesterol 2.71 1 0 0.0 0.00 1.0000 C4orf22
Asthma (self-reported) 0.77 1 0 0.0 0.00 1.0000 EPC1
Forced expiratory volume in 1-second (FEV1), predicted percentage 5.76 5 2 6.1 -0.52 0.3720 C10orf11 EPC1 KIAA1267 LRRC37A2 PRRX1
Average weekly champagne plus white wine intake 2.17 2 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2
Miserableness 2.34 2 2 6.1 0.00 1.0000 KIAA1267 LRRC37A2
Guilty feelings 2.28 2 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2
Medication: Blood pressure 3.05 3 1 3.0 0.00 1.0000 C4orf22 KIAA1267 LRRC37A2
Medication: Paracetamol 4.33 3 2 6.1 0.00 1.0000 COMMD7 KIAA1267 LRRC37A2
Medication: Lisinopril 1.46 1 0 0.0 0.00 1.0000 C4orf22
Illnesses of father: High blood pressure 2.02 1 0 0.0 0.00 1.0000 C4orf22
Ever smoked 1.57 1 0 0.0 0.00 1.0000 PCCA
Leg fat percentage (left) 0.78 1 0 0.0 0.00 1.0000 PRRX1
Irritability 3.29 2 2 6.1 0.00 1.0000 KIAA1267 LRRC37A2
Fractured/broken bones in last 5 years 2.36 2 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2
Diastolic blood pressure, automated reading 1.31 1 1 3.0 0.00 1.0000 C4orf22
Ever depressed for a whole week 2.41 2 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2
Myopia 2.33 3 0 0.0 0.00 1.0000 KIAA1267 LRRC37A2 PCCA
Vascular/heart problems diagnosed by doctor 2.59 1 1 3.0 0.00 1.0000 C4orf22
Cholesterol lowering medication 1.83 1 0 0.0 0.00 1.0000 SGPP2
Pain experienced in last month 1.70 1 0 0.0 0.00 1.0000 COMMD7
Impedance of whole body 1.44 3 2 6.1 0.00 1.0000 KIAA1267 LRRC37A2 MNS1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.24
GTEx Adipose Visceral Omentum 2 0.0982 1.27
GTEx Adrenal Gland 1 0.0686 1.34
GTEx Artery Aorta 3 0.1008 1.27
GTEx Artery Coronary 3 0.2536 1.32
GTEx Artery Tibial 2 0.0532 1.24
GTEx Brain Caudate basal ganglia 2 0.2174 1.34
GTEx Brain Cerebellar Hemisphere 2 0.1343 1.38
GTEx Brain Cerebellum 3 0.1514 1.35
GTEx Brain Cortex 2 0.1932 1.41
GTEx Brain Frontal Cortex BA9 2 0.2165 1.36
GTEx Brain Hippocampus 1 0.1908 1.47
GTEx Brain Hypothalamus 1 0.1695 1.43
GTEx Brain Nucleus accumbens basal ganglia 2 0.2312 1.38
GTEx Brain Putamen basal ganglia 1 0.1603 1.34
GTEx Breast Mammary Tissue 2 0.1013 1.26
GTEx Breast Mammary Tissue (Male) 2 0.1676 1.39
GTEx Breast Mammary Tissue (Female) 2 0.1217 1.27
GTEx Cells EBV-transformed lymphocytes 2 0.1405 1.39
GTEx Cells Transformed fibroblasts 4 0.0953 1.28
GTEx Colon Sigmoid 1 0.0684 1.29
GTEx Colon Transverse 4 0.1938 1.39
GTEx Esophagus Gastroesophageal Junction 4 0.2768 1.36
GTEx Esophagus Mucosa 3 0.0904 1.32
GTEx Esophagus Muscularis 3 0.0928 1.29
GTEx Heart Atrial Appendage 2 0.1267 1.34
GTEx Heart Left Ventricle 1 0.0654 1.34
GTEx Liver 1 0.1395 1.35
GTEx Lung 2 0.0696 1.29
GTEx Muscle Skeletal 2 0.0692 1.28
GTEx Nerve Tibial 4 0.0926 1.26
GTEx Ovary 2 0.2203 1.41
GTEx Pancreas 2 0.1225 1.42
GTEx Pituitary 1 0.0897 1.35
GTEx Prostate 1 0.1198 1.38
GTEx Skin Not Sun Exposed Suprapubic 3 0.1220 1.32
GTEx Skin Sun Exposed Lower leg 2 0.0549 1.28
GTEx Small Intestine Terminal Ileum 1 0.2169 1.35
GTEx Spleen 3 0.2126 1.31
GTEx Stomach 3 0.2063 1.41
GTEx Testis 3 0.0951 1.27
GTEx Thyroid 4 0.1000 1.28
GTEx Uterus 1 0.1764 1.40
GTEx Vagina 4 0.6299 1.55
GTEx Whole Blood 1 0.0502 1.25
METSIM Adipose 0 0.0000 1.22
NTR Blood 1 0.0416 1.32
ROSMAP Brain Pre-frontal Cortex 2 0.0455 1.23
YFS Blood 2 0.0433 1.22
CommonMind Brain Pre-frontal Cortex 5 0.0930 1.26
TCGA Breast Tumor 2 0.2608 1.37
TCGA Breast Normal 2 0.0475 1.23
TCGA Ovarian Tumor 5 0.1711 1.23
TCGA Prostate Tumor 3 0.0867 1.26