Hub : Traits :

Medication: Metformin

37 significantly associated models · 14 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 42767044 44157441 1 1 1.3e-08 1.4e-09 1.3e-02 83 AC010883.5
2 4 5575751 7002344 1 1 9.5e-12 6.9e-13 4.7e-03 84 WFS1
3 4 52683607 53582065 1 1 1.1e-07 5.0e-07 8.5e-01 100 LRRC66
4 4 103020804 104627833 2 1 1.6e-07 1.1e-06 1.7e-01 92 UBE2D3
5 10 11693166 13569805 1 1 9.2e-09 1.2e-08 1.0e+00 100 CAMK1D
6 10 93730592 95128815 1 1 9.4e-12 7.7e-12 7.0e-02 93 EIF2S2P3
7 10 113511441 115622375 2 1 4.8e-30 2.5e-100 3.1e-76 24 TCF7L2
8 15 89680384 91152345 1 1 1.6e-07 5.1e-08 1.0e+00 100 AP3S2
9 19 12352086 13750618 1 1 1.1e-07 1.4e-07 2.9e-01 96 CALR
10 19 45313715 46693262 1 1 8.3e-08 6.6e-05 2.2e-01 91 PPM1N

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 2.73 3 1 3.0 0.00 1.0e+00 AC010883.5 EIF2S2P3 PPM1N
Irritable Bowel Disease (IBD) 3.26 2 1 3.0 0.00 1.0e+00 AC010883.5 EIF2S2P3
Ulcerative Colitis (UC) 3.03 3 0 0.0 0.00 1.0e+00 AC010883.5 EIF2S2P3 UBE2D3
Breast Cancer 3.60 2 1 3.0 0.00 1.0e+00 CALR TCF7L2
Body Mass Index (BMI) (2010) 2.01 1 0 0.0 0.00 1.0e+00 TCF7L2
Crohns Disease (2012) 1.93 1 0 0.0 0.00 1.0e+00 AC010883.5
Fasting Glucose 4.57 1 0 0.0 0.00 1.0e+00 TCF7L2
Primary Biliary Cirrhosis 2.29 1 0 0.0 0.00 1.0e+00 UBE2D3
Schizophrenia 1.41 1 0 0.0 0.00 1.0e+00 UBE2D3
Type 2 Diabetes (T2D) 16.39 5 2 6.1 -0.95 1.3e-02 AC010883.5 EIF2S2P3 TCF7L2 UBE2D3 WFS1
Ulcerative Colitis 2.43 1 0 0.0 0.00 1.0e+00 AC010883.5
Blood Eosinophil Count 2.41 2 2 6.1 0.00 1.0e+00 AC010883.5 EIF2S2P3
Blood Platelet Count 4.76 4 2 6.1 -0.55 4.5e-01 AC010883.5 AP3S2 LRRC66 PPM1N
Blood Red Count 3.25 3 2 6.1 0.00 1.0e+00 CALR EIF2S2P3 PPM1N
Blood White Count 0.28 1 0 0.0 0.00 1.0e+00 LRRC66
Heel T-Score 1.39 3 1 3.0 0.00 1.0e+00 AC010883.5 CALR TCF7L2
BMI 1.96 4 1 3.0 0.98 1.6e-02 LRRC66 PPM1N TCF7L2 UBE2D3
Height 0.99 4 3 9.1 0.45 5.5e-01 AC010883.5 CALR LRRC66 UBE2D3
Waist Hip Ratio (WHR) 3.25 3 2 6.1 0.00 1.0e+00 AC010883.5 EIF2S2P3 TCF7L2
Systolic Blood Pressure 2.19 3 2 6.1 0.00 1.0e+00 CAMK1D LRRC66 TCF7L2
Allergy or Eczema 2.09 2 0 0.0 0.00 1.0e+00 AC010883.5 UBE2D3
Cardiovascular Disease 2.61 4 1 3.0 0.51 4.9e-01 CAMK1D LRRC66 PPM1N UBE2D3
Hypothyroidism (self reported) 1.24 1 0 0.0 0.00 1.0e+00 AC010883.5
Respiratory disease 2.16 1 1 3.0 0.00 1.0e+00 EIF2S2P3
Type 2 Diabetes (T2D) 36.52 9 8 24.2 -1.00 2.0e-09 AC010883.5 AP3S2 CALR CAMK1D EIF2S2P3 LRRC66 PPM1N TCF7L2 WFS1
Lung FEV1/FVC ratio 4.73 3 2 6.1 0.00 1.0e+00 AC010883.5 CAMK1D PPM1N
Lung FVC 1.25 1 1 3.0 0.00 1.0e+00 CAMK1D
Neuroticism 1.22 1 0 0.0 0.00 1.0e+00 AC010883.5
Chronotype (morning person) 2.54 1 1 3.0 0.00 1.0e+00 PPM1N
Hair Pigment 0.13 1 0 0.0 0.00 1.0e+00 AC010883.5
Hand grip strength (left) 1.22 1 0 0.0 0.00 1.0e+00 AC010883.5
Number of treatments/medications taken 3.68 2 1 3.0 0.00 1.0e+00 LRRC66 UBE2D3
Sensitivity / hurt feelings 1.12 1 0 0.0 0.00 1.0e+00 UBE2D3
Systolic blood pressure, automated reading 2.39 2 1 3.0 0.00 1.0e+00 CAMK1D LRRC66
Eye problems/disorders: Diabetes related eye disease 5.38 1 0 0.0 0.00 1.0e+00 TCF7L2
Diabetes (father) 18.22 5 3 9.1 0.99 5.1e-04 AC010883.5 AP3S2 EIF2S2P3 TCF7L2 WFS1
Diabetes (mother) 16.92 6 2 6.1 0.99 9.7e-05 AC010883.5 CALR CAMK1D EIF2S2P3 TCF7L2 WFS1
Impedance of leg (right) 1.38 1 1 3.0 0.00 1.0e+00 AC010883.5
Leg fat-free mass (left) 1.03 3 0 0.0 0.00 1.0e+00 LRRC66 TCF7L2 WFS1
Trunk fat percentage 1.20 3 0 0.0 0.00 1.0e+00 AC010883.5 LRRC66 TCF7L2
Maternal smoking around birth 1.38 1 0 0.0 0.00 1.0e+00 AC010883.5
Fed-up feelings 1.70 1 0 0.0 0.00 1.0e+00 AC010883.5
Taking other prescription medications 1.77 1 0 0.0 0.00 1.0e+00 UBE2D3
Heel bone mineral density (BMD) T-score, automated (left) 1.81 2 0 0.0 0.00 1.0e+00 AC010883.5 UBE2D3
High blood pressure 2.36 2 1 3.0 0.00 1.0e+00 CAMK1D UBE2D3
Hayfever, allergic rhinitis or eczema 1.66 1 0 0.0 0.00 1.0e+00 AC010883.5
Sitting height 0.45 1 0 0.0 0.00 1.0e+00 UBE2D3
Body mass index (BMI) 1.76 2 1 3.0 0.00 1.0e+00 LRRC66 TCF7L2
Impedance of leg (left) 1.53 2 1 3.0 0.00 1.0e+00 AC010883.5 UBE2D3
Leg predicted mass (left) 1.07 3 0 0.0 0.00 1.0e+00 LRRC66 TCF7L2 WFS1
Trunk fat mass 1.38 2 0 0.0 0.00 1.0e+00 LRRC66 TCF7L2
Waist circumference 1.32 3 0 0.0 0.00 1.0e+00 LRRC66 TCF7L2 WFS1
Forced vital capacity (FVC) 1.47 3 0 0.0 0.00 1.0e+00 CALR CAMK1D UBE2D3
Heel bone mineral density (BMD) T-score, automated (right) 1.42 1 0 0.0 0.00 1.0e+00 AC010883.5
Heart attack 2.75 1 0 0.0 0.00 1.0e+00 AC010883.5
Allergy 1.95 2 0 0.0 0.00 1.0e+00 AC010883.5 UBE2D3
Diabetes (self-reported) 27.33 10 5 15.2 0.99 5.9e-08 AC010883.5 AP3S2 CALR CAMK1D EIF2S2P3 LRRC66 PPM1N TCF7L2 UBE2D3 WFS1
Medication: Ramipril 3.85 1 0 0.0 0.00 1.0e+00 UBE2D3
Medication: Simvastatin 4.63 3 0 0.0 0.00 1.0e+00 LRRC66 PPM1N TCF7L2
Neuroticism score 1.53 1 0 0.0 0.00 1.0e+00 AC010883.5
Weight 1.42 3 1 3.0 0.00 1.0e+00 LRRC66 TCF7L2 WFS1
Impedance of arm (right) 2.02 3 1 3.0 0.00 1.0e+00 CALR TCF7L2 UBE2D3
Arm fat percentage (right) 1.29 3 0 0.0 0.00 1.0e+00 LRRC66 PPM1N TCF7L2
Trunk fat-free mass 0.97 2 0 0.0 0.00 1.0e+00 LRRC66 WFS1
Hip circumference 2.31 2 1 3.0 0.00 1.0e+00 LRRC66 TCF7L2
Father's age at death 2.07 1 0 0.0 0.00 1.0e+00 LRRC66
Worrier / anxious feelings 1.75 1 0 0.0 0.00 1.0e+00 TCF7L2
Number of live births 1.51 1 0 0.0 0.00 1.0e+00 UBE2D3
Forced expiratory volume in 1-second (FEV1) 2.73 2 1 3.0 0.00 1.0e+00 CALR CAMK1D
Pulse rate 2.49 1 0 0.0 0.00 1.0e+00 WFS1
Asthma 2.13 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Medication: Cholesterol lowering 4.83 1 0 0.0 0.00 1.0e+00 TCF7L2
Forced expiratory volume in 1-second (FEV1), Best measure 2.62 1 1 3.0 0.00 1.0e+00 CAMK1D
Impedance of arm (left) 2.42 4 1 3.0 -0.41 5.9e-01 AC010883.5 CALR TCF7L2 UBE2D3
Arm fat mass (right) 1.57 2 1 3.0 0.00 1.0e+00 LRRC66 TCF7L2
Trunk predicted mass 0.95 2 0 0.0 0.00 1.0e+00 LRRC66 WFS1
Standing height 0.82 2 0 0.0 0.00 1.0e+00 CALR LRRC66
Hair/balding pattern: Pattern 4 1.46 1 0 0.0 0.00 1.0e+00 AC010883.5
Peak expiratory flow (PEF) 3.39 2 2 6.1 0.00 1.0e+00 AC010883.5 CAMK1D
Headache pain in last month 1.70 1 0 0.0 0.00 1.0e+00 UBE2D3
Medication for cholesterol, blood pressure or diabetes 5.39 3 0 0.0 0.00 1.0e+00 CAMK1D PPM1N UBE2D3
Birth weight 3.59 2 1 3.0 0.00 1.0e+00 AC010883.5 EIF2S2P3
Forced vital capacity (FVC), Best measure 1.29 1 0 0.0 0.00 1.0e+00 CAMK1D
Body fat percentage 1.45 2 0 0.0 0.00 1.0e+00 AC010883.5 TCF7L2
Leg fat percentage (right) 1.96 1 1 3.0 0.00 1.0e+00 TCF7L2
Arm fat-free mass (right) 1.13 1 0 0.0 0.00 1.0e+00 LRRC66
Reason for reducing amount of alcohol drunk: Health precaution 2.38 1 0 0.0 0.00 1.0e+00 UBE2D3
Age at first live birth 1.79 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Medication for pain relief, constipation, heartburn 2.29 1 0 0.0 0.00 1.0e+00 UBE2D3
Medication: Blood pressure 3.82 3 1 3.0 0.00 1.0e+00 CAMK1D PPM1N UBE2D3
Migraine (self-reported) 2.13 1 0 0.0 0.00 1.0e+00 UBE2D3
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.44 2 0 0.0 0.00 1.0e+00 EIF2S2P3 TCF7L2
Whole body fat mass 1.62 2 0 0.0 0.00 1.0e+00 LRRC66 TCF7L2
Leg fat mass (right) 1.91 2 1 3.0 0.00 1.0e+00 LRRC66 TCF7L2
Arm predicted mass (right) 1.12 1 0 0.0 0.00 1.0e+00 LRRC66
Pulse rate, automated reading 2.53 4 1 3.0 0.94 5.6e-02 AC010883.5 EIF2S2P3 TCF7L2 WFS1
Alcohol intake frequency. 1.90 2 0 0.0 0.00 1.0e+00 LRRC66 WFS1
Comparative height size at age 10 1.39 3 1 3.0 0.00 1.0e+00 AC010883.5 EIF2S2P3 LRRC66
Overall health rating 1.64 1 0 0.0 0.00 1.0e+00 UBE2D3
Age at last live birth 1.67 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Medication: Aspirin 4.31 1 1 3.0 0.00 1.0e+00 LRRC66
Hypertension (Self-reported) 2.45 2 1 3.0 0.00 1.0e+00 CAMK1D UBE2D3
Illnesses of siblings: Diabetes 10.13 5 2 6.1 0.99 1.7e-03 AC010883.5 CAMK1D EIF2S2P3 TCF7L2 WFS1
Smoking status: Previous 1.48 1 0 0.0 0.00 1.0e+00 CALR
Whole body fat-free mass 1.04 2 0 0.0 0.00 1.0e+00 LRRC66 WFS1
Leg fat-free mass (right) 0.95 2 0 0.0 0.00 1.0e+00 LRRC66 WFS1
Arm fat percentage (left) 1.26 2 0 0.0 0.00 1.0e+00 LRRC66 TCF7L2
Mood swings 1.38 1 0 0.0 0.00 1.0e+00 AC010883.5
Diabetes diagnosed by doctor 31.39 10 6 18.2 1.00 1.3e-09 AC010883.5 AP3S2 CALR CAMK1D EIF2S2P3 LRRC66 PPM1N TCF7L2 UBE2D3 WFS1
Qualifications: nursing, teaching 1.35 1 0 0.0 0.00 1.0e+00 TCF7L2
Medication for cholesterol 2.32 1 0 0.0 0.00 1.0e+00 UBE2D3
Breast cancer (self-reported) 1.83 1 0 0.0 0.00 1.0e+00 TCF7L2
Asthma (self-reported) 1.96 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Medication: Aspirin 4.51 1 0 0.0 0.00 1.0e+00 LRRC66
Medication: Gliclazide 13.55 4 1 3.0 1.00 6.1e-04 PPM1N TCF7L2 UBE2D3 WFS1
Illnesses of father: None of the above (group 1) 2.73 1 0 0.0 0.00 1.0e+00 CAMK1D
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.03 1 1 3.0 0.00 1.0e+00 CAMK1D
Whole body water mass 1.00 2 0 0.0 0.00 1.0e+00 LRRC66 WFS1
Leg predicted mass (right) 0.95 2 0 0.0 0.00 1.0e+00 LRRC66 WFS1
Arm fat mass (left) 1.45 2 0 0.0 0.00 1.0e+00 LRRC66 TCF7L2
Number of self-reported non-cancer illnesses 2.58 1 0 0.0 0.00 1.0e+00 UBE2D3
Guilty feelings 1.60 1 0 0.0 0.00 1.0e+00 AP3S2
Medication: Blood pressure 2.00 1 0 0.0 0.00 1.0e+00 UBE2D3
Medication: Paracetamol 2.72 1 0 0.0 0.00 1.0e+00 UBE2D3
Medication: Atorvastatin 3.32 2 0 0.0 0.00 1.0e+00 PPM1N TCF7L2
Basal metabolic rate 1.10 3 0 0.0 0.00 1.0e+00 LRRC66 TCF7L2 WFS1
Leg fat percentage (left) 2.00 1 1 3.0 0.00 1.0e+00 TCF7L2
Arm fat-free mass (left) 1.25 3 0 0.0 0.00 1.0e+00 LRRC66 TCF7L2 WFS1
Irritability 2.22 1 0 0.0 0.00 1.0e+00 AC010883.5
Diastolic blood pressure, automated reading 1.42 2 0 0.0 0.00 1.0e+00 TCF7L2 UBE2D3
Vascular/heart problems diagnosed by doctor 2.77 3 1 3.0 0.00 1.0e+00 CAMK1D PPM1N UBE2D3
Cholesterol lowering medication 3.38 2 0 0.0 0.00 1.0e+00 LRRC66 TCF7L2
Heart attack/myocardial infarction (self-reported) 2.47 1 0 0.0 0.00 1.0e+00 AC010883.5
Alcohol drinker status: Previous 1.93 1 0 0.0 0.00 1.0e+00 CALR
Impedance of whole body 1.93 4 2 6.1 -0.39 6.1e-01 AC010883.5 TCF7L2 UBE2D3 WFS1
Leg fat mass (left) 1.93 2 1 3.0 0.00 1.0e+00 LRRC66 TCF7L2
Arm predicted mass (left) 1.18 2 0 0.0 0.00 1.0e+00 LRRC66 WFS1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.43
GTEx Adipose Visceral Omentum 0 0.0000 1.41
GTEx Adrenal Gland 0 0.0000 1.40
GTEx Artery Aorta 1 0.0336 1.49
GTEx Artery Coronary 0 0.0000 1.34
GTEx Artery Tibial 0 0.0000 1.45
GTEx Brain Caudate basal ganglia 0 0.0000 1.31
GTEx Brain Cerebellar Hemisphere 1 0.0672 1.47
GTEx Brain Cerebellum 1 0.0505 1.46
GTEx Brain Cortex 1 0.0966 1.49
GTEx Brain Frontal Cortex BA9 0 0.0000 1.43
GTEx Brain Hippocampus 0 0.0000 1.36
GTEx Brain Hypothalamus 0 0.0000 1.26
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.27
GTEx Brain Putamen basal ganglia 0 0.0000 1.31
GTEx Breast Mammary Tissue 0 0.0000 1.45
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.42
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.42
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.44
GTEx Cells Transformed fibroblasts 2 0.0476 1.45
GTEx Colon Sigmoid 0 0.0000 1.35
GTEx Colon Transverse 0 0.0000 1.36
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.40
GTEx Esophagus Mucosa 1 0.0301 1.45
GTEx Esophagus Muscularis 1 0.0309 1.48
GTEx Heart Atrial Appendage 1 0.0633 1.43
GTEx Heart Left Ventricle 0 0.0000 1.40
GTEx Liver 0 0.0000 1.36
GTEx Lung 1 0.0348 1.46
GTEx Muscle Skeletal 2 0.0692 1.44
GTEx Nerve Tibial 0 0.0000 1.45
GTEx Ovary 0 0.0000 1.52
GTEx Pancreas 0 0.0000 1.44
GTEx Pituitary 0 0.0000 1.46
GTEx Prostate 1 0.1198 1.39
GTEx Skin Not Sun Exposed Suprapubic 1 0.0407 1.51
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.47
GTEx Small Intestine Terminal Ileum 0 0.0000 1.34
GTEx Spleen 1 0.0709 1.51
GTEx Stomach 0 0.0000 1.40
GTEx Testis 1 0.0317 1.46
GTEx Thyroid 3 0.0750 1.49
GTEx Uterus 0 0.0000 1.17
GTEx Vagina 0 0.0000 1.42
GTEx Whole Blood 2 0.1004 1.43
METSIM Adipose 1 0.0217 1.36
NTR Blood 4 0.1665 1.42
ROSMAP Brain Pre-frontal Cortex 2 0.0455 1.41
YFS Blood 2 0.0433 1.37
CommonMind Brain Pre-frontal Cortex 2 0.0372 1.45
TCGA Breast Tumor 0 0.0000 1.42
TCGA Breast Normal 2 0.0475 1.34
TCGA Ovarian Tumor 0 0.0000 1.24
TCGA Prostate Tumor 2 0.0578 1.36