Hub : Traits :

Financial situation satisfaction

2 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 48702606 50085153 1 1 9.4e-09 5.4e-07 0.22 94 GPX1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 15.98 1 1 3 0 1 GPX1
Irritable Bowel Disease (IBD) 24.32 1 1 3 0 1 GPX1
Ulcerative Colitis (UC) 21.91 1 1 3 0 1 GPX1
Major Depression (MDD) 14.00 1 0 0 0 1 GPX1
Verbal and Numeric Reasoning (VNR) 13.20 1 1 3 0 1 GPX1
Breast Cancer 2.87 1 0 0 0 1 GPX1
Prostate Cancer 14.65 1 0 0 0 1 GPX1
Age at First Birth 24.71 1 1 3 0 1 GPX1
Crohns Disease (2012) 6.29 1 0 0 0 1 GPX1
Neuroticism 14.63 1 0 0 0 1 GPX1
Ulcerative Colitis 19.00 1 1 3 0 1 GPX1
Blood Eosinophil Count 2.51 1 0 0 0 1 GPX1
Blood Platelet Count 0.72 1 0 0 0 1 GPX1
Blood White Count 2.69 1 0 0 0 1 GPX1
Heel T-Score 0.80 1 0 0 0 1 GPX1
BMI 12.62 1 1 3 0 1 GPX1
Height 3.76 1 1 3 0 1 GPX1
Waist Hip Ratio (WHR) 6.57 1 1 3 0 1 GPX1
Systolic Blood Pressure 4.71 1 0 0 0 1 GPX1
Smoking Status 13.72 1 1 3 0 1 GPX1
Cardiovascular Disease 3.43 1 0 0 0 1 GPX1
Hypothyroidism (self reported) 2.49 1 0 0 0 1 GPX1
Lung FVC 5.00 1 1 3 0 1 GPX1
Neuroticism 14.79 1 1 3 0 1 GPX1
Chronotype (morning person) 5.35 1 0 0 0 1 GPX1
Number of treatments/medications taken 12.20 1 0 0 0 1 GPX1
Average weekly spirits intake 5.28 1 0 0 0 1 GPX1
Frequency of depressed mood in last 2 weeks 4.18 1 0 0 0 1 GPX1
Relative age of first facial hair 2.76 1 0 0 0 1 GPX1
Systolic blood pressure, automated reading 11.16 1 1 3 0 1 GPX1
Medication: Co-codamol 11.78 1 0 0 0 1 GPX1
Pack years adult smoking proportion 15.45 1 0 0 0 1 GPX1
Impedance of leg (right) 5.47 1 1 3 0 1 GPX1
Leg fat-free mass (left) 2.90 1 0 0 0 1 GPX1
Trunk fat percentage 4.41 1 0 0 0 1 GPX1
Townsend deprivation index at recruitment 3.83 1 0 0 0 1 GPX1
Current tobacco smoking 7.65 1 0 0 0 1 GPX1
Maternal smoking around birth 7.38 1 0 0 0 1 GPX1
Fed-up feelings 27.70 1 1 3 0 1 GPX1
Frequency of unenthusiasm / disinterest in last 2 weeks 11.48 1 0 0 0 1 GPX1
Taking other prescription medications 16.41 1 0 0 0 1 GPX1
Age when periods started (menarche) 16.18 1 1 3 0 1 GPX1
Tinnitus: Yes, but not now, but have in the past 6.69 1 0 0 0 1 GPX1
Qualifications: CSEs or equivalent 9.03 1 0 0 0 1 GPX1
High blood pressure 2.26 1 0 0 0 1 GPX1
Stomach or abdominal pain in last month 4.60 1 0 0 0 1 GPX1
Body mass index (BMI) 17.71 1 1 3 0 1 GPX1
Impedance of leg (left) 5.28 1 1 3 0 1 GPX1
Leg predicted mass (left) 2.88 1 0 0 0 1 GPX1
Trunk fat mass 5.46 1 0 0 0 1 GPX1
Waist circumference 4.03 1 0 0 0 1 GPX1
Past tobacco smoking 4.60 1 0 0 0 1 GPX1
Alcohol usually taken with meals 5.31 1 0 0 0 1 GPX1
Frequency of tenseness / restlessness in last 2 weeks 14.66 1 0 0 0 1 GPX1
Had menopause 4.67 1 0 0 0 1 GPX1
Forced vital capacity (FVC) 6.85 1 1 3 0 1 GPX1
Ever unenthusiastic/disinterested for a whole week 8.61 1 0 0 0 1 GPX1
Qualifications: None of the above 22.95 1 1 3 0 1 GPX1
Financial difficulties in last 2 years 8.59 1 0 0 0 1 GPX1
Mouth/teeth dental problems 4.03 1 0 0 0 1 GPX1
Heart attack 4.78 1 0 0 0 1 GPX1
Pain all over the body in last month 13.58 1 0 0 0 1 GPX1
Fluid intelligence score 7.60 1 0 0 0 1 GPX1
Illnesses of siblings 4.42 1 0 0 0 1 GPX1
Neuroticism score 14.66 1 1 3 0 1 GPX1
Weight 6.82 1 1 3 0 1 GPX1
Impedance of arm (right) 17.05 1 1 3 0 1 GPX1
Arm fat percentage (right) 9.36 1 1 3 0 1 GPX1
Trunk fat-free mass 2.04 1 0 0 0 1 GPX1
Hip circumference 8.35 1 1 3 0 1 GPX1
Alcohol intake versus 10 years previously 7.93 1 0 0 0 1 GPX1
Father's age at death 16.72 1 0 0 0 1 GPX1
Frequency of tiredness / lethargy in last 2 weeks 14.24 1 0 0 0 1 GPX1
Forced expiratory volume in 1-second (FEV1) 9.24 1 1 3 0 1 GPX1
Pulse rate 3.99 1 0 0 0 1 GPX1
Noisy workplace 8.87 1 0 0 0 1 GPX1
Qualifications: A levels/AS levels or equivalent 26.03 1 1 3 0 1 GPX1
Mouth/teeth dental problems: Dentures 13.16 1 0 0 0 1 GPX1
Lung cancer (father) 12.43 1 0 0 0 1 GPX1
Forced expiratory volume in 1-second (FEV1), Best measure 9.86 1 1 3 0 1 GPX1
Impedance of arm (left) 18.42 1 1 3 0 1 GPX1
Arm fat mass (right) 10.62 1 1 3 0 1 GPX1
Trunk predicted mass 1.88 1 0 0 0 1 GPX1
Standing height 2.98 1 1 3 0 1 GPX1
Exposure to tobacco smoke at home 13.05 1 0 0 0 1 GPX1
Tense / 'highly strung' 4.56 1 0 0 0 1 GPX1
Seen doctor (GP) for nerves, anxiety, tension or depression 10.51 1 0 0 0 1 GPX1
Hair/balding pattern: Pattern 4 2.42 1 0 0 0 1 GPX1
Ever highly irritable/argumentative for 2 days 10.90 1 0 0 0 1 GPX1
Qualifications: O levels/GCSEs or equivalent 18.29 1 1 3 0 1 GPX1
Medication: Paracetamol 16.00 1 1 3 0 1 GPX1
Forced vital capacity (FVC), Best measure 8.16 1 1 3 0 1 GPX1
Body fat percentage 7.95 1 1 3 0 1 GPX1
Leg fat percentage (right) 15.08 1 1 3 0 1 GPX1
Arm fat-free mass (right) 4.74 1 0 0 0 1 GPX1
Exposure to tobacco smoke outside home 5.83 1 0 0 0 1 GPX1
Comparative body size at age 10 2.17 1 0 0 0 1 GPX1
Number of full brothers 11.90 1 0 0 0 1 GPX1
Seen a psychiatrist for nerves, anxiety, tension or depression 7.32 1 0 0 0 1 GPX1
Wheeze or whistling in the chest in last year 9.38 1 0 0 0 1 GPX1
Age at first live birth 22.01 1 1 3 0 1 GPX1
Health satisfaction 12.13 1 0 0 0 1 GPX1
Qualifications: College or University degree 34.46 1 1 3 0 1 GPX1
Emphysema/chronic bronchitis 7.05 1 0 0 0 1 GPX1
Medication for pain relief, constipation, heartburn 12.11 1 0 0 0 1 GPX1
Neck or shoulder pain in last month 14.93 1 0 0 0 1 GPX1
Medication: Omeprazole 5.77 1 0 0 0 1 GPX1
Medication: Seretide 50 evohaler 10.24 1 0 0 0 1 GPX1
Whole body fat mass 9.29 1 1 3 0 1 GPX1
Leg fat mass (right) 14.06 1 1 3 0 1 GPX1
Arm predicted mass (right) 4.81 1 0 0 0 1 GPX1
Pulse rate, automated reading 3.86 1 0 0 0 1 GPX1
Comparative height size at age 10 4.78 1 1 3 0 1 GPX1
Number of full sisters 4.96 1 0 0 0 1 GPX1
Overall health rating 24.80 1 1 3 0 1 GPX1
Chest pain or discomfort 10.82 1 0 0 0 1 GPX1
Had major operations 12.15 1 0 0 0 1 GPX1
Age at last live birth 23.22 1 1 3 0 1 GPX1
Leg pain on walking 7.06 1 0 0 0 1 GPX1
Commuting to job workplace: Car/motor vehicle 5.24 1 0 0 0 1 GPX1
Knee pain experienced in last month 7.15 1 0 0 0 1 GPX1
Hypertension (Self-reported) 1.92 1 0 0 0 1 GPX1
Illnesses of siblings: Diabetes 6.07 1 0 0 0 1 GPX1
Whole body fat-free mass 2.70 1 0 0 0 1 GPX1
Leg fat-free mass (right) 2.47 1 0 0 0 1 GPX1
Arm fat percentage (left) 8.81 1 1 3 0 1 GPX1
Mood swings 27.26 1 1 3 0 1 GPX1
Loneliness, isolation 19.17 1 1 3 0 1 GPX1
Qualifications: nursing, teaching 5.76 1 0 0 0 1 GPX1
Medication: Laxatives (e.g. Dulcolax, Senokot) 10.93 1 0 0 0 1 GPX1
Back pain experienced in last month 6.22 1 0 0 0 1 GPX1
Osteoarthritis (self-reported) 7.00 1 0 0 0 1 GPX1
Smoking status: Current 7.39 1 0 0 0 1 GPX1
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.70 1 0 0 0 1 GPX1
Whole body water mass 2.92 1 0 0 0 1 GPX1
Leg predicted mass (right) 2.38 1 0 0 0 1 GPX1
Arm fat mass (left) 9.94 1 1 3 0 1 GPX1
Number of self-reported non-cancer illnesses 5.76 1 0 0 0 1 GPX1
Miserableness 35.27 1 1 3 0 1 GPX1
Guilty feelings 8.53 1 0 0 0 1 GPX1
Mother's age at death 6.52 1 0 0 0 1 GPX1
Commuting to job workplace: Public transport 6.16 1 0 0 0 1 GPX1
Medication: Paracetamol 16.22 1 1 3 0 1 GPX1
Ever smoked 5.34 1 0 0 0 1 GPX1
Basal metabolic rate 3.80 1 0 0 0 1 GPX1
Leg fat percentage (left) 15.67 1 1 3 0 1 GPX1
Arm fat-free mass (left) 5.72 1 1 3 0 1 GPX1
Number of operations (self-reported) 11.64 1 0 0 0 1 GPX1
Average weekly beer plus cider intake 7.64 1 0 0 0 1 GPX1
Irritability 13.51 1 0 0 0 1 GPX1
Age started oral contraceptive pill 11.32 1 0 0 0 1 GPX1
Diastolic blood pressure, automated reading 6.56 1 0 0 0 1 GPX1
Ever depressed for a whole week 8.98 1 0 0 0 1 GPX1
Vascular/heart problems diagnosed by doctor 3.82 1 0 0 0 1 GPX1
Pain experienced in last month 18.48 1 1 3 0 1 GPX1
Heart attack/myocardial infarction (self-reported) 4.76 1 0 0 0 1 GPX1
Heart disease (siblings) 5.21 1 0 0 0 1 GPX1
Pack years of smoking 12.64 1 0 0 0 1 GPX1
Impedance of whole body 13.58 1 1 3 0 1 GPX1
Leg fat mass (left) 14.89 1 1 3 0 1 GPX1
Arm predicted mass (left) 5.50 1 1 3 0 1 GPX1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.30
GTEx Adipose Visceral Omentum 0 0.0000 1.31
GTEx Adrenal Gland 0 0.0000 1.19
GTEx Artery Aorta 0 0.0000 1.31
GTEx Artery Coronary 0 0.0000 1.26
GTEx Artery Tibial 0 0.0000 1.26
GTEx Brain Caudate basal ganglia 0 0.0000 1.36
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.34
GTEx Brain Cerebellum 0 0.0000 1.26
GTEx Brain Cortex 0 0.0000 1.26
GTEx Brain Frontal Cortex BA9 1 0.1082 1.31
GTEx Brain Hippocampus 0 0.0000 1.26
GTEx Brain Hypothalamus 0 0.0000 1.16
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.20
GTEx Brain Putamen basal ganglia 0 0.0000 1.21
GTEx Breast Mammary Tissue 0 0.0000 1.33
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.24
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.25
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.32
GTEx Cells Transformed fibroblasts 0 0.0000 1.26
GTEx Colon Sigmoid 0 0.0000 1.40
GTEx Colon Transverse 0 0.0000 1.27
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.28
GTEx Esophagus Mucosa 0 0.0000 1.28
GTEx Esophagus Muscularis 0 0.0000 1.29
GTEx Heart Atrial Appendage 0 0.0000 1.27
GTEx Heart Left Ventricle 0 0.0000 1.21
GTEx Liver 0 0.0000 1.19
GTEx Lung 1 0.0348 1.33
GTEx Muscle Skeletal 0 0.0000 1.22
GTEx Nerve Tibial 0 0.0000 1.30
GTEx Ovary 0 0.0000 1.35
GTEx Pancreas 0 0.0000 1.32
GTEx Pituitary 0 0.0000 1.28
GTEx Prostate 0 0.0000 1.19
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.31
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.29
GTEx Small Intestine Terminal Ileum 0 0.0000 1.30
GTEx Spleen 0 0.0000 1.34
GTEx Stomach 0 0.0000 1.26
GTEx Testis 0 0.0000 1.26
GTEx Thyroid 0 0.0000 1.27
GTEx Uterus 0 0.0000 1.20
GTEx Vagina 0 0.0000 1.28
GTEx Whole Blood 0 0.0000 1.24
METSIM Adipose 0 0.0000 1.20
NTR Blood 0 0.0000 1.20
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.24
YFS Blood 0 0.0000 1.17
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.24
TCGA Breast Tumor 0 0.0000 1.16
TCGA Breast Normal 0 0.0000 1.15
TCGA Ovarian Tumor 0 0.0000 1.13
TCGA Prostate Tumor 0 0.0000 1.21