Hub : Traits :

Mouth/teeth dental problems: Dentures

114 significantly associated models · 32 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 43991832 45378361 1 1 3.0e-07 1.3e-05 3.4e-04 32 DMAP1
2 1 154238383 155910830 11 1 6.7e-11 1.9e-09 4.0e-02 88 GBAP1
3 3 49016056 50833360 7 1 2.5e-08 2.2e-08 2.7e-01 96 RBM6
4 5 133377162 134784086 1 1 5.8e-08 5.3e-37 8.3e-33 12 CAMLG
5 6 25296606 26689223 1 3 3.6e-14 1.1e-23 7.5e-12 53 U91328.19
6 15 62716641 64367745 4 3 4.4e-13 8.8e-16 1.9e-04 78 CA12 LACTB
7 17 40120771 41510850 1 1 3.6e-07 4.0e-05 7.2e-01 99 TUBG2
8 17 45228469 46899254 3 2 3.6e-09 7.3e-07 6.2e-01 99 RP11-6N17.3 SP6
9 19 48464978 49935001 3 1 4.9e-08 5.1e-08 3.1e-01 96 RASIP1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 3.26 3 1 3.0 0.00 1.00000 GBAP1 RASIP1 RBM6
Irritable Bowel Disease (IBD) 3.44 2 2 6.1 0.00 1.00000 GBAP1 RBM6
Ulcerative Colitis (UC) 2.62 2 1 3.0 0.00 1.00000 GBAP1 RBM6
Verbal and Numeric Reasoning (VNR) 2.88 2 1 3.0 0.00 1.00000 RBM6 U91328.19
Breast Cancer 1.59 1 0 0.0 0.00 1.00000 GBAP1
Ovarian Cancer 1.88 1 0 0.0 0.00 1.00000 RP11-6N17.3
Age at First Birth 3.73 1 1 3.0 0.00 1.00000 RBM6
Coronary Artery Disease (CAD) 2.01 1 0 0.0 0.00 1.00000 RBM6
Crohns Disease (2012) 2.95 1 0 0.0 0.00 1.00000 RBM6
HDL Cholesterol 3.64 2 0 0.0 0.00 1.00000 LACTB RBM6
LDL Cholesterol 2.69 2 1 3.0 0.00 1.00000 RASIP1 SP6
Ulcerative Colitis 2.75 1 0 0.0 0.00 1.00000 RBM6
Blood Eosinophil Count 1.02 3 1 3.0 0.00 1.00000 LACTB RBM6 RP11-6N17.3
Blood Platelet Count 2.33 4 4 12.1 -0.99 0.00063 GBAP1 LACTB RASIP1 SP6
Blood Red Count 1.16 2 2 6.1 0.00 1.00000 GBAP1 RP11-6N17.3
Blood White Count 2.31 3 2 6.1 0.00 1.00000 RBM6 RP11-6N17.3 TUBG2
Heel T-Score 1.48 2 2 6.1 0.00 1.00000 GBAP1 RBM6
BMI 4.23 4 1 3.0 -0.25 0.74541 RBM6 RP11-6N17.3 SP6 TUBG2
Height 1.06 3 3 9.1 0.00 1.00000 CAMLG RASIP1 TUBG2
Waist Hip Ratio (WHR) 1.32 2 1 3.0 0.00 1.00000 GBAP1 RASIP1
Systolic Blood Pressure 2.39 3 2 6.1 0.00 1.00000 LACTB RASIP1 RP11-6N17.3
Allergy or Eczema 1.97 1 1 3.0 0.00 1.00000 TUBG2
Cardiovascular Disease 2.99 1 1 3.0 0.00 1.00000 RASIP1
Hypothyroidism (self reported) 2.93 1 0 0.0 0.00 1.00000 RASIP1
Respiratory disease 1.40 1 0 0.0 0.00 1.00000 RBM6
Type 2 Diabetes (T2D) 2.01 1 0 0.0 0.00 1.00000 RBM6
Lung FEV1/FVC ratio 1.27 2 1 3.0 0.00 1.00000 LACTB RASIP1
Lung FVC 1.59 3 1 3.0 0.00 1.00000 GBAP1 RBM6 SP6
Neuroticism 1.18 1 0 0.0 0.00 1.00000 RBM6
Chronotype (morning person) 1.99 2 0 0.0 0.00 1.00000 CAMLG RASIP1
Hair Pigment 1.59 3 3 9.1 0.00 1.00000 GBAP1 RP11-6N17.3 SP6
Tanning 0.31 1 0 0.0 0.00 1.00000 SP6
Number of treatments/medications taken 3.19 2 1 3.0 0.00 1.00000 RASIP1 RBM6
Average weekly spirits intake 1.89 1 0 0.0 0.00 1.00000 RASIP1
Frequency of depressed mood in last 2 weeks 2.07 1 0 0.0 0.00 1.00000 GBAP1
Systolic blood pressure, automated reading 2.68 2 1 3.0 0.00 1.00000 LACTB RASIP1
Vitamin and mineral supplements 2.40 1 0 0.0 0.00 1.00000 U91328.19
Medication: Co-codamol 2.08 1 0 0.0 0.00 1.00000 RBM6
Medication: Metformin 1.95 1 0 0.0 0.00 1.00000 TUBG2
Impedance of leg (right) 1.42 3 1 3.0 0.00 1.00000 GBAP1 RBM6 TUBG2
Leg fat-free mass (left) 4.16 5 2 6.1 0.61 0.14620 GBAP1 RASIP1 RBM6 TUBG2 U91328.19
Trunk fat percentage 4.89 4 2 6.1 0.98 0.00076 RBM6 RP11-6N17.3 TUBG2 U91328.19
Fed-up feelings 1.75 1 1 3.0 0.00 1.00000 RBM6
Taking other prescription medications 2.91 1 1 3.0 0.00 1.00000 RBM6
Age when periods started (menarche) 1.48 2 0 0.0 0.00 1.00000 RASIP1 RBM6
Heel bone mineral density (BMD) T-score, automated (left) 2.59 2 0 0.0 0.00 1.00000 RBM6 U91328.19
Qualifications: CSEs or equivalent 1.07 1 0 0.0 0.00 1.00000 RBM6
High blood pressure 1.11 1 0 0.0 0.00 1.00000 RASIP1
Hayfever, allergic rhinitis or eczema 5.20 2 2 6.1 -0.98 0.02166 TUBG2 U91328.19
Medication: Levothyroxine sodium 4.51 1 1 3.0 0.00 1.00000 U91328.19
Sitting height 1.81 3 2 6.1 0.63 0.25944 CAMLG RASIP1 U91328.19
Body mass index (BMI) 6.04 3 2 6.1 0.94 0.01630 RBM6 TUBG2 U91328.19
Impedance of leg (left) 1.60 3 1 3.0 0.00 1.00000 GBAP1 RBM6 TUBG2
Leg predicted mass (left) 4.15 5 2 6.1 0.61 0.14848 GBAP1 RASIP1 RBM6 TUBG2 U91328.19
Trunk fat mass 6.06 4 3 9.1 0.97 0.00133 RBM6 RP11-6N17.3 TUBG2 U91328.19
Waist circumference 4.26 5 2 6.1 0.94 0.00503 RBM6 RP11-6N17.3 SP6 TUBG2 U91328.19
Past tobacco smoking 1.14 1 0 0.0 0.00 1.00000 GBAP1
Nervous feelings 2.56 1 1 3.0 0.00 1.00000 U91328.19
Frequency of tenseness / restlessness in last 2 weeks 1.77 1 0 0.0 0.00 1.00000 RBM6
Hearing difficulty/problems with background noise 2.54 1 0 0.0 0.00 1.00000 U91328.19
Forced vital capacity (FVC) 1.60 2 0 0.0 0.00 1.00000 CAMLG RBM6
Heel bone mineral density (BMD) T-score, automated (right) 2.42 2 0 0.0 0.00 1.00000 RBM6 U91328.19
Qualifications: None of the above 2.90 2 1 3.0 0.00 1.00000 DMAP1 RBM6
Mouth/teeth dental problems 6.13 3 1 3.0 0.00 1.00000 GBAP1 RASIP1 SP6
Allergy 3.77 2 1 3.0 0.96 0.04344 TUBG2 U91328.19
Diabetes (self-reported) 2.03 1 0 0.0 0.00 1.00000 RBM6
Hayfever/allergic rhinitis (self-reported) 3.47 1 0 0.0 0.00 1.00000 U91328.19
Medication: Simvastatin 2.33 1 0 0.0 0.00 1.00000 RASIP1
Fluid intelligence score 3.02 1 1 3.0 0.00 1.00000 RBM6
Neuroticism score 1.64 2 0 0.0 0.00 1.00000 RBM6 U91328.19
Weight 6.41 6 3 9.1 0.80 0.01713 RASIP1 RBM6 RP11-6N17.3 SP6 TUBG2 U91328.19
Impedance of arm (right) 2.59 2 1 3.0 0.00 1.00000 RBM6 U91328.19
Arm fat percentage (right) 4.66 4 2 6.1 0.96 0.00295 RBM6 RP11-6N17.3 TUBG2 U91328.19
Trunk fat-free mass 3.19 5 2 6.1 0.78 0.03693 CAMLG RASIP1 RBM6 TUBG2 U91328.19
Hip circumference 6.11 4 3 9.1 0.76 0.07845 RASIP1 RBM6 TUBG2 U91328.19
Alcohol intake versus 10 years previously 3.08 2 1 3.0 0.00 1.00000 RASIP1 RBM6
Number of live births 1.92 1 0 0.0 0.00 1.00000 RBM6
Forced expiratory volume in 1-second (FEV1) 1.92 2 0 0.0 0.00 1.00000 RBM6 U91328.19
Noisy workplace 2.51 1 0 0.0 0.00 1.00000 DMAP1
Qualifications: A levels/AS levels or equivalent 4.61 2 1 3.0 0.00 1.00000 DMAP1 RBM6
Serious illness, injury or assault of a close relative in last 2 years 1.72 1 0 0.0 0.00 1.00000 RASIP1
Asthma 1.29 1 0 0.0 0.00 1.00000 RBM6
Medication: Cholesterol lowering 2.83 1 0 0.0 0.00 1.00000 RASIP1
Prospective memory result 1.61 1 0 0.0 0.00 1.00000 RBM6
Forced expiratory volume in 1-second (FEV1), Best measure 1.69 2 0 0.0 0.00 1.00000 RBM6 U91328.19
Impedance of arm (left) 2.46 2 1 3.0 0.00 1.00000 RBM6 U91328.19
Arm fat mass (right) 6.25 5 3 9.1 0.94 0.00197 RBM6 RP11-6N17.3 SP6 TUBG2 U91328.19
Trunk predicted mass 3.16 5 2 6.1 0.78 0.03788 CAMLG RASIP1 RBM6 TUBG2 U91328.19
Standing height 1.64 3 2 6.1 0.82 0.09023 CAMLG RASIP1 U91328.19
Exposure to tobacco smoke at home 1.73 1 0 0.0 0.00 1.00000 RBM6
Tense / 'highly strung' 1.46 1 0 0.0 0.00 1.00000 U91328.19
Peak expiratory flow (PEF) 1.80 1 0 0.0 0.00 1.00000 RASIP1
Ever highly irritable/argumentative for 2 days 2.57 1 1 3.0 0.00 1.00000 RBM6
Qualifications: O levels/GCSEs or equivalent 2.37 2 0 0.0 0.00 1.00000 DMAP1 RBM6
Headache pain in last month 1.97 1 0 0.0 0.00 1.00000 U91328.19
Medication for cholesterol, blood pressure or diabetes 2.23 2 0 0.0 0.00 1.00000 RASIP1 RBM6
Hypothyroidism/myxoedema (self-reported) 4.24 2 1 3.0 0.92 0.08465 RASIP1 U91328.19
Medication: Ventolin 100micrograms inhaler 1.56 1 0 0.0 0.00 1.00000 RBM6
Birth weight 0.85 1 0 0.0 0.00 1.00000 RASIP1
Chronic bronchitis/emphysema (mother) 1.91 1 0 0.0 0.00 1.00000 RBM6
Forced vital capacity (FVC), Best measure 1.32 1 0 0.0 0.00 1.00000 RBM6
Body fat percentage 5.36 4 2 6.1 0.96 0.00204 RBM6 RP11-6N17.3 TUBG2 U91328.19
Leg fat percentage (right) 5.89 2 2 6.1 0.99 0.01287 RBM6 U91328.19
Arm fat-free mass (right) 4.52 4 2 6.1 0.78 0.07013 RASIP1 RBM6 TUBG2 U91328.19
Exposure to tobacco smoke outside home 1.94 1 0 0.0 0.00 1.00000 RBM6
Comparative body size at age 10 1.87 2 0 0.0 0.00 1.00000 RASIP1 U91328.19
Seen a psychiatrist for nerves, anxiety, tension or depression 3.34 1 1 3.0 0.00 1.00000 U91328.19
Wheeze or whistling in the chest in last year 2.58 1 1 3.0 0.00 1.00000 RBM6
Age at first live birth 4.87 2 1 3.0 0.00 1.00000 DMAP1 RBM6
Health satisfaction 1.65 1 0 0.0 0.00 1.00000 RBM6
Shortness of breath walking on level ground 1.16 1 0 0.0 0.00 1.00000 RBM6
Qualifications: College or University degree 5.33 3 2 6.1 0.00 1.00000 DMAP1 RBM6 U91328.19
Medication for pain relief, constipation, heartburn 1.93 1 0 0.0 0.00 1.00000 SP6
Medication: Seretide 50 evohaler 2.75 1 0 0.0 0.00 1.00000 RBM6
Whole body fat mass 6.49 4 2 6.1 0.95 0.00306 RBM6 RP11-6N17.3 TUBG2 U91328.19
Leg fat mass (right) 7.14 3 2 6.1 0.95 0.01229 RBM6 TUBG2 U91328.19
Arm predicted mass (right) 4.78 4 2 6.1 0.79 0.06393 RASIP1 RBM6 TUBG2 U91328.19
Pulse rate, automated reading 2.31 4 0 0.0 -0.11 0.88650 CA12 DMAP1 RBM6 U91328.19
Alcohol intake frequency. 3.59 3 2 6.1 0.00 1.00000 RASIP1 RBM6 TUBG2
Comparative height size at age 10 1.31 3 1 3.0 0.00 1.00000 CAMLG RASIP1 SP6
Overall health rating 3.16 1 1 3.0 0.00 1.00000 RBM6
Chest pain or discomfort 2.12 1 0 0.0 0.00 1.00000 RBM6
Age at last live birth 5.68 2 1 3.0 0.00 1.00000 DMAP1 RBM6
Leg pain on walking 2.25 1 0 0.0 0.00 1.00000 RBM6
Qualifications: NVQ or HND or HNC or equivalent 2.79 1 0 0.0 0.00 1.00000 RBM6
Supplements: Vitamin C 2.29 1 0 0.0 0.00 1.00000 U91328.19
Knee pain experienced in last month 1.58 1 0 0.0 0.00 1.00000 RBM6
Hypertension (Self-reported) 1.42 1 1 3.0 0.00 1.00000 RASIP1
Smoking status: Previous 1.10 1 0 0.0 0.00 1.00000 GBAP1
Forced expiratory volume in 1-second (FEV1), predicted 1.84 1 0 0.0 0.00 1.00000 CAMLG
Whole body fat-free mass 3.73 5 2 6.1 0.79 0.03338 CAMLG RASIP1 RBM6 TUBG2 U91328.19
Leg fat-free mass (right) 3.62 5 2 6.1 0.58 0.17255 GBAP1 RASIP1 RBM6 TUBG2 U91328.19
Arm fat percentage (left) 4.72 4 3 9.1 0.95 0.00305 RBM6 RP11-6N17.3 TUBG2 U91328.19
Average weekly red wine intake 1.77 1 0 0.0 0.00 1.00000 RBM6
Mood swings 2.02 1 1 3.0 0.00 1.00000 RBM6
Diabetes diagnosed by doctor 2.43 2 0 0.0 0.00 1.00000 RBM6 TUBG2
Qualifications: nursing, teaching 2.14 1 0 0.0 0.00 1.00000 RBM6
Medication for cholesterol 1.84 1 0 0.0 0.00 1.00000 RASIP1
Asthma (self-reported) 1.46 1 0 0.0 0.00 1.00000 RBM6
Osteoarthritis (self-reported) 1.99 1 0 0.0 0.00 1.00000 RBM6
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.99 1 1 3.0 0.00 1.00000 U91328.19
Whole body water mass 3.69 4 2 6.1 0.81 0.05280 RASIP1 RBM6 TUBG2 U91328.19
Leg predicted mass (right) 3.61 5 2 6.1 0.58 0.16948 GBAP1 RASIP1 RBM6 TUBG2 U91328.19
Arm fat mass (left) 6.26 4 3 9.1 0.95 0.00336 RBM6 RP11-6N17.3 TUBG2 U91328.19
Number of self-reported non-cancer illnesses 1.94 2 0 0.0 0.00 1.00000 RASIP1 RBM6
Miserableness 2.45 1 1 3.0 0.00 1.00000 RBM6
Guilty feelings 1.83 1 0 0.0 0.00 1.00000 U91328.19
Hearing aid user 1.64 1 0 0.0 0.00 1.00000 RP11-6N17.3
Financial situation satisfaction 3.43 1 0 0.0 0.00 1.00000 RBM6
Medication: Blood pressure 1.04 1 0 0.0 0.00 1.00000 RASIP1
Supplements: Fish oil (including cod liver oil) 1.82 1 0 0.0 0.00 1.00000 U91328.19
High cholesterol (Self-reported) 4.43 1 1 3.0 0.00 1.00000 RASIP1
Medication: Bendroflumethiazide 1.16 1 0 0.0 0.00 1.00000 RASIP1
Medication: Atorvastatin 4.34 1 0 0.0 0.00 1.00000 RASIP1
Basal metabolic rate 4.49 4 2 6.1 0.81 0.05033 RASIP1 RBM6 TUBG2 U91328.19
Leg fat percentage (left) 6.00 2 2 6.1 0.99 0.01327 RBM6 U91328.19
Arm fat-free mass (left) 4.78 4 2 6.1 0.80 0.05701 RASIP1 RBM6 TUBG2 U91328.19
Number of operations (self-reported) 1.42 1 0 0.0 0.00 1.00000 RBM6
Average weekly beer plus cider intake 2.12 1 1 3.0 0.00 1.00000 RBM6
Age started oral contraceptive pill 1.38 1 0 0.0 0.00 1.00000 RBM6
Diastolic blood pressure, automated reading 1.49 2 0 0.0 0.00 1.00000 RASIP1 RBM6
Vascular/heart problems diagnosed by doctor 1.30 1 0 0.0 0.00 1.00000 RASIP1
Cholesterol lowering medication 3.43 1 0 0.0 0.00 1.00000 RASIP1
Pain experienced in last month 1.85 1 0 0.0 0.00 1.00000 RBM6
Impedance of whole body 1.98 2 1 3.0 0.00 1.00000 RBM6 U91328.19
Leg fat mass (left) 7.30 3 2 6.1 0.95 0.01221 RBM6 TUBG2 U91328.19
Arm predicted mass (left) 4.75 4 2 6.1 0.80 0.05801 RASIP1 RBM6 TUBG2 U91328.19

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.0573 1.73
GTEx Adipose Visceral Omentum 3 0.1473 1.75
GTEx Adrenal Gland 2 0.1373 1.70
GTEx Artery Aorta 3 0.1008 1.65
GTEx Artery Coronary 0 0.0000 1.79
GTEx Artery Tibial 3 0.0798 1.69
GTEx Brain Caudate basal ganglia 0 0.0000 1.65
GTEx Brain Cerebellar Hemisphere 4 0.2686 1.79
GTEx Brain Cerebellum 3 0.1514 1.79
GTEx Brain Cortex 2 0.1932 1.79
GTEx Brain Frontal Cortex BA9 3 0.3247 1.79
GTEx Brain Hippocampus 0 0.0000 1.62
GTEx Brain Hypothalamus 0 0.0000 1.70
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.68
GTEx Brain Putamen basal ganglia 1 0.1603 1.68
GTEx Breast Mammary Tissue 2 0.1013 1.74
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.51
GTEx Breast Mammary Tissue (Female) 2 0.1217 1.73
GTEx Cells EBV-transformed lymphocytes 1 0.0703 1.80
GTEx Cells Transformed fibroblasts 4 0.0953 1.76
GTEx Colon Sigmoid 2 0.1368 1.67
GTEx Colon Transverse 2 0.0969 1.77
GTEx Esophagus Gastroesophageal Junction 3 0.2076 1.78
GTEx Esophagus Mucosa 5 0.1506 1.79
GTEx Esophagus Muscularis 1 0.0309 1.77
GTEx Heart Atrial Appendage 2 0.1267 1.79
GTEx Heart Left Ventricle 2 0.1307 1.82
GTEx Liver 2 0.2789 1.83
GTEx Lung 3 0.1044 1.77
GTEx Muscle Skeletal 1 0.0346 1.76
GTEx Nerve Tibial 4 0.0926 1.72
GTEx Ovary 1 0.1101 1.75
GTEx Pancreas 2 0.1225 1.74
GTEx Pituitary 1 0.0897 1.83
GTEx Prostate 2 0.2395 1.80
GTEx Skin Not Sun Exposed Suprapubic 5 0.2033 1.75
GTEx Skin Sun Exposed Lower leg 4 0.1099 1.70
GTEx Small Intestine Terminal Ileum 2 0.4338 2.00
GTEx Spleen 5 0.3544 1.93
GTEx Stomach 1 0.0688 1.84
GTEx Testis 1 0.0317 1.77
GTEx Thyroid 4 0.1000 1.75
GTEx Uterus 0 0.0000 1.59
GTEx Vagina 1 0.1575 1.65
GTEx Whole Blood 3 0.1505 1.76
METSIM Adipose 3 0.0651 1.58
NTR Blood 1 0.0416 1.66
ROSMAP Brain Pre-frontal Cortex 2 0.0455 1.61
YFS Blood 2 0.0433 1.60
CommonMind Brain Pre-frontal Cortex 2 0.0372 1.61
TCGA Breast Tumor 2 0.2608 1.72
TCGA Breast Normal 3 0.0713 1.57
TCGA Ovarian Tumor 3 0.1027 1.63
TCGA Prostate Tumor 2 0.0578 1.70