Hub : Genes

TCAIM

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1080	0.0420	8.5e-05	0.029	NA	0.034	NA	0.040	2.0e-03	NA	8.1e-04	NA	2.8e-04
2	GTEx	Artery Coronary	0.2270	0.0800	4.1e-04	-0.005	NA	0.082	NA	0.033	4.9e-01	NA	9.9e-04	NA	2.8e-02
3	GTEx	Artery Tibial	0.0389	0.0206	9.6e-03	0.012	NA	0.019	NA	0.017	3.9e-02	NA	1.1e-02	NA	1.5e-02
4	GTEx	Brain Hippocampus	0.1216	0.0599	8.7e-03	-0.009	NA	-0.002	NA	-0.005	6.1e-01	NA	3.6e-01	NA	4.3e-01
5	GTEx	Cells Transformed fibroblasts	0.0730	0.0330	9.0e-04	0.044	NA	0.042	NA	0.059	3.0e-04	NA	3.9e-04	NA	3.2e-05
6	GTEx	Lung	0.0546	0.0262	9.1e-03	0.005	NA	0.013	NA	0.002	1.2e-01	NA	3.0e-02	NA	2.2e-01
7	GTEx	Spleen	0.2870	0.1280	6.5e-03	0.010	NA	0.014	NA	0.002	1.7e-01	NA	1.4e-01	NA	2.8e-01
8	GTEx	Whole Blood	0.0750	0.0290	3.5e-05	0.088	NA	0.083	NA	0.077	1.6e-08	NA	4.5e-08	NA	1.5e-07
9	METSIM	Adipose	0.0535	0.0219	5.2e-04	0.024	0.032	0.030	0.030	0.027	1.2e-04	1.3e-05	2.3e-05	2.1e-05	4.7e-05
10	ROSMAP	Brain Pre-frontal Cortex	0.2030	0.0466	0.0e+00	0.123	0.174	0.173	0.185	0.183	1.4e-15	8.0e-22	1.1e-21	3.0e-23	5.4e-23

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.4	2.2	4.6	-2.1	1.2	-2.1	-1.7	-1.6	-0.6	-1.7	0.0	-1.8	0.4
Bipolar Disorder or Schizophrenia	0.7	1.8	5.1	-1.3	0.4	-2.3	-1.4	-1.9	0.7	-0.4	-0.5	-1.2	-1.7
Depressed Affect (Nagel 2018)	2.1	4.4	13.8	-2.0	-2.3	-2.5	-3.7	-2.6	-1.2	-1.5	0.1	-1.7	-1.0
Depression (Nagel 2018)	1.8	2.8	12.3	0.4	-1.6	-1.6	-3.5	-1.8	0.3	1.6	1.5	0.8	-1.1
Intelligence (Savage-Jansen 2018)	1.1	3.4	8.1	2.2	0.4	2.2	2.5	2.5	0.1	1.7	-0.0	2.8	0.1
Neuroticism (Nagel 2018)	4.0	9.3	22.0	-3.3	-2.5	-4.1	-4.7	-3.4	-1.7	-2.7	-0.5	-3.3	-2.1
Schizophrenia (2018)	0.6	1.3	6.2	0.0	-0.6	-1.2	-0.4	-1.2	1.4	0.8	-0.7	-0.1	-2.5
Schizophrenia vs Biploar Disorder	0.4	0.6	2.0	0.7	-1.4	-0.0	0.3	0.0	0.7	0.9	-0.4	0.7	-1.1
Worry (Nagel 2018)	4.5	9.5	18.0	-3.3	-1.7	-4.2	-3.6	-3.3	-2.3	-3.2	-1.2	-3.9	-2.7
Alzheimer’s Disease (in mother)	0.6	0.7	3.6	-0.0	0.8	0.5	1.9	1.1	-0.5	-0.9	-0.5	-0.1	0.0
Alzheimer’s Disease (in father)	0.8	0.8	2.5	0.4	1.0	1.3	0.3	1.2	0.3	0.3	0.3	1.0	1.6
Alzheimer’s Disease (including proxy)	1.2	1.7	4.2	0.8	1.8	1.3	1.1	1.9	0.1	-0.3	1.0	1.0	2.0
Crohns Disease (2017)	0.2	0.4	1.2	-1.0	-0.2	0.1	0.2	0.0	-1.1	-0.7	0.1	-0.6	1.0
Irritable Bowel Disease (IBD)	0.1	0.4	0.9	-1.0	0.6	-0.0	0.1	-0.5	-0.8	-0.5	-0.1	-0.7	0.8
Ulcerative Colitis (UC)	0.2	0.3	1.9	-0.5	1.4	0.2	0.5	-0.1	-0.4	-0.2	-0.2	-0.3	0.5
Major Depression (MDD)	2.5	3.1	13.2	0.8	-0.9	-2.2	-3.6	-2.3	1.6	0.5	1.8	-0.2	-0.4
Reaction Time	0.4	0.8	2.6	0.3	-0.9	-0.2	-1.6	-0.5	0.3	0.0	1.2	-0.9	1.4
Verbal and Numeric Reasoning (VNR)	0.3	0.8	3.0	1.0	-0.3	0.9	-0.2	0.7	-1.0	1.1	0.4	1.7	-0.4
Breast Cancer	0.2	0.5	2.0	0.3	-0.4	0.0	-0.5	-0.3	0.6	0.9	1.4	0.1	1.1
Ovarian Cancer	1.3	1.7	4.8	0.3	1.5	1.6	-0.0	1.7	1.9	-0.1	1.1	-0.1	2.2
Prostate Cancer	0.4	0.6	1.8	-0.0	0.9	-0.5	0.9	-0.6	1.4	0.2	0.8	-0.3	0.9
Age at First Birth	1.2	1.8	7.6	-0.3	-0.1	-0.0	2.5	-0.3	0.2	0.5	-1.9	-0.2	-2.8
Bipolar Disorder (2011)	1.4	1.4	4.4	-1.2	1.4	-0.2	0.2	0.5	0.0	-2.1	0.3	-1.3	2.0
Body Mass Index (BMI) (2010)	0.8	1.1	4.3	-0.6	-2.1	-0.3	-1.2	-0.4	-0.8	-1.0	-0.2	-1.7	-0.4
Coronary Artery Disease (CAD)	0.9	1.1	3.9	-0.2	-2.0	-0.8	-1.5	-0.4	-2.0	0.1	0.5	-0.0	-0.0
Crohns Disease (2012)	0.3	0.4	1.4	-1.2	-0.3	0.7	0.3	0.1	-0.9	-0.6	-0.9	-0.3	0.5
Mean Putamen Volume	0.8	0.9	2.4	0.3	-0.8	-0.8	-0.8	-1.2	-1.4	0.6	-0.6	-0.4	-1.6
Fasting Glucose	0.5	0.6	2.0	-0.1	-0.5	0.6	-1.4	0.2	0.8	0.1	1.1	-0.3	1.4
HbA1C	1.4	1.6	4.7	-1.5	0.5	-0.4	1.5	-0.4	-0.9	-0.9	-2.2	-0.8	-1.9
HDL Cholesterol	3.2	5.3	9.6	2.5	3.0	2.5	1.8	1.9	1.7	3.1	1.4	2.9	1.2
LDL Cholesterol	0.5	0.8	2.8	-0.6	1.7	0.4	1.5	0.6	-0.1	-0.9	-0.9	-0.4	0.6
Lupus	0.1	0.2	0.9	0.8	-0.3	0.1	0.4	0.1	0.5	0.9	0.5	0.2	-0.3
Neuroticism (2016)	3.4	4.9	12.7	-2.3	-1.4	-3.4	-3.6	-3.0	0.1	-1.4	-0.2	-2.5	-0.7
Primary Biliary Cirrhosis	0.3	0.4	1.1	0.8	-0.4	1.1	0.1	0.9	0.7	-0.0	0.6	-0.2	0.0
Rheumatoid Arthritis	1.3	1.8	5.8	-1.6	-1.3	-0.5	0.4	-0.2	-1.2	-2.0	-1.1	-2.4	-0.8
Schizophrenia (2014)	0.4	0.9	5.3	0.4	-0.3	-0.9	-0.6	-0.6	1.1	0.6	-0.4	0.2	-2.3
Triglycerides	0.9	1.5	5.2	-1.4	-0.8	-1.3	0.0	-0.4	-0.7	-2.3	-0.2	-2.0	1.1
Type 2 Diabetes (T2D) (2012)	1.1	1.2	2.1	-0.5	-1.4	1.0	1.4	1.4	-1.4	-1.0	-0.7	-1.1	0.7
Ulcerative Colitis	0.9	1.3	5.2	-0.7	-0.1	-1.5	-2.3	-2.0	-0.8	-0.2	0.6	-0.5	0.0
Blood Eosinophil Count	0.5	3.9	6.8	2.4	2.2	1.9	0.5	1.9	2.6	1.6	2.0	2.1	1.5
Blood Platelet Count	0.1	1.4	5.9	1.4	-0.4	-0.7	-1.8	-0.5	1.3	0.9	2.4	-0.0	-0.2
Blood Red Count	0.1	0.8	2.5	0.3	-0.7	1.1	1.2	1.2	-0.4	-0.2	0.8	-0.6	1.6
Blood White Count	0.2	1.1	4.3	0.1	-1.9	-0.6	-0.7	-0.4	-0.6	-0.8	0.6	-2.1	-1.0
Heel T-Score	1.2	9.6	19.7	-3.9	-1.5	-4.1	-2.5	-4.4	-1.7	-2.9	-2.1	-3.3	-2.7
BMI	0.7	4.2	16.7	-1.1	-4.1	1.8	-1.0	1.9	-3.0	-1.2	0.6	-1.1	2.0
Height	0.1	1.6	3.5	-1.9	-1.2	-0.4	-1.6	-0.6	-1.9	-0.6	-1.3	-0.0	-1.6
Waist Hip Ratio (WHR)	1.4	6.3	13.2	-3.5	1.5	-2.1	-0.4	-2.3	-1.4	-3.3	-3.3	-3.6	-1.1
Systolic Blood Pressure	0.3	1.6	4.0	0.2	-0.3	1.9	1.6	2.0	-0.3	-0.4	0.9	-0.8	1.8
Smoking Status	0.8	1.9	6.9	-0.6	-1.9	-1.9	-2.6	-1.3	-0.2	-0.9	-0.6	-0.8	-1.2
Allergy or Eczema	1.3	3.5	6.7	-2.3	-1.7	-2.5	-1.5	-2.6	-2.0	-1.6	-1.2	-1.7	-0.6
Cardiovascular Disease	0.4	1.3	2.8	1.0	-1.2	1.7	0.6	1.7	-0.5	0.7	1.1	0.2	1.4
Hypothyroidism (self reported)	1.9	4.5	8.0	-2.5	-2.3	-1.2	0.6	-1.4	-2.3	-2.7	-2.4	-2.8	-1.9
Respiratory disease	0.1	0.2	1.1	0.1	0.4	-0.2	-0.6	-0.1	0.2	0.4	1.0	0.4	0.1
Type 2 Diabetes (T2D) (2018)	1.0	1.9	5.8	-1.2	-2.4	-1.0	0.5	-0.7	-1.3	-1.1	-1.3	-2.1	-0.8
Lung FEV1/FVC ratio	1.5	7.8	16.8	3.7	-0.5	4.0	1.3	4.1	2.4	2.6	1.7	3.1	1.9
Lung FVC	0.5	2.7	9.1	2.4	3.0	0.9	-0.3	0.4	-0.2	2.0	1.3	2.3	0.6
Neuroticism	2.2	5.4	14.7	-2.5	-1.4	-3.3	-3.8	-2.6	-1.0	-2.1	-0.1	-2.6	-1.0
Chronotype (morning person)	0.3	0.8	2.4	-1.1	0.1	0.3	-1.5	0.0	-0.7	-0.7	0.6	-1.6	0.8
Hair Pigment	0.0	0.9	5.4	-0.1	-1.5	-0.5	-2.3	-0.7	-0.2	0.1	0.6	0.0	-0.5
Tanning	0.0	0.4	1.9	0.1	-0.6	-0.2	1.4	0.2	0.1	0.5	-0.8	-0.1	-0.7
Hand grip strength (left)	0.1	0.4	1.0	-0.4	-0.5	-1.0	-1.0	-1.0	-0.1	0.4	0.3	-0.2	0.1
Number of treatments/medications taken	3.5	6.3	10.3	-3.0	-3.0	-2.9	-3.1	-2.5	-1.7	-2.5	-0.3	-3.2	-1.0
Average weekly spirits intake	0.3	0.3	0.9	0.5	-0.4	0.8	0.1	0.4	-0.3	0.9	0.7	0.4	0.4
Sensitivity / hurt feelings	1.5	2.6	6.8	0.2	-1.9	-2.4	-2.6	-2.2	0.4	0.7	1.9	-0.2	-0.7
Frequency of depressed mood in last 2 weeks	2.1	3.0	13.7	1.4	-0.9	-0.6	-3.7	-0.5	0.7	2.0	2.5	1.3	-0.4
Hearing difficulty/problems: Yes	1.8	2.7	6.0	2.3	1.3	2.1	0.1	2.2	-0.0	1.1	1.1	2.4	1.5
Relative age of first facial hair	0.2	0.4	1.3	-0.2	0.9	-0.4	-0.3	-0.1	1.0	-1.1	-0.3	-0.8	0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.1	0.8	1.2	-0.0	-1.5	-0.4	1.1	0.3	1.0	0.6	1.0
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.8	-0.1	-0.9	0.4	-0.6	0.4	-0.6	-0.4	0.2	-0.7	0.6
Ever had hysterectomy (womb removed)	0.2	0.3	1.3	-0.2	-0.1	0.6	-1.1	0.1	0.5	-0.1	0.4	0.5	0.6
Systolic blood pressure, automated reading	0.2	0.7	2.3	-0.1	-0.2	1.5	1.1	1.3	-0.0	0.0	0.3	-0.8	0.7
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.8	-0.3	-1.4	-1.3	-0.4	-1.0	-0.1	0.1	0.1	0.0	-0.2
Angina	1.0	1.3	3.1	0.6	-1.6	0.4	-1.0	0.8	-1.8	-0.7	1.7	-1.2	0.9
Medication for hormone replacement therapy	0.9	1.0	4.1	-0.6	-0.4	-1.5	-1.2	-2.0	0.6	0.5	0.4	-0.4	-0.7
Vitamin and mineral supplements	0.6	0.9	1.5	-0.3	-0.5	1.2	1.1	1.2	-1.2	-1.2	-0.2	-0.4	1.0
Supplements: Zinc	0.9	1.0	2.9	0.9	1.6	0.7	-0.3	0.3	0.8	1.4	0.2	1.7	-0.3
Medication: Co-codamol	0.8	0.9	3.0	0.1	-0.8	-0.7	-1.7	-0.5	1.7	0.6	1.1	-0.2	0.5
Medication: Metformin	1.5	2.1	11.4	-0.0	-3.4	-0.2	1.1	-0.3	-1.7	0.1	-1.4	-1.0	-1.6
Diabetes (father)	2.5	3.1	5.6	1.6	1.0	2.1	1.2	2.3	2.4	1.1	1.3	2.3	1.5
Diabetes (mother)	2.6	3.3	6.5	-2.6	-1.7	-1.7	-0.0	-1.7	-0.8	-1.7	-2.4	-1.9	-2.1
Severe depression (siblings)	0.8	0.9	3.3	-0.1	1.3	0.6	0.3	1.0	1.2	-0.4	1.1	0.2	1.8
Pack years adult smoking proportion	1.3	2.0	4.8	1.6	-1.1	0.2	-2.0	-0.0	1.4	2.2	1.7	1.6	0.1
Impedance of leg (right)	1.2	6.0	15.8	-2.0	-1.3	-3.9	-3.1	-4.0	-0.0	-1.2	-1.1	-1.9	-2.7
Leg fat-free mass (left)	0.4	2.3	4.1	1.1	-1.6	2.0	-0.6	2.0	-0.9	0.9	1.9	1.5	1.7
Trunk fat percentage	1.5	5.9	13.7	-1.6	-3.7	2.3	1.1	2.9	-3.7	-2.5	-0.6	-1.3	2.5
Hand grip strength (right)	0.6	1.5	3.6	-1.8	-0.8	-1.7	-1.7	-1.9	-0.9	-0.1	-0.4	-1.0	-0.3
Townsend deprivation index at recruitment	1.2	1.7	4.6	2.1	-0.5	0.5	-0.9	0.6	1.8	1.9	1.6	0.8	0.2
Current tobacco smoking	0.8	1.4	5.8	0.1	-2.4	-1.0	-1.9	-0.6	0.4	-0.3	0.1	-1.1	-1.3
Average weekly fortified wine intake	0.6	0.7	3.1	0.5	1.6	-0.1	0.0	-0.2	1.8	0.6	0.7	0.5	-0.1
Maternal smoking around birth	0.8	1.2	4.3	-0.2	-0.6	1.9	1.4	2.1	-0.2	-0.5	-1.2	-0.5	0.2
Fed-up feelings	1.9	3.4	10.9	-1.4	-3.3	-1.7	-2.7	-1.7	-1.5	-1.2	-0.3	-1.6	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	6.7	0.8	-0.4	-0.6	-2.6	-0.7	0.9	1.6	1.8	1.4	-0.1
Relative age voice broke	0.3	0.5	1.6	-0.7	-1.1	-0.2	-0.1	-0.3	-0.7	-1.3	-0.3	-1.0	0.4
Taking other prescription medications	3.5	5.4	15.2	-1.7	-3.9	-2.8	-2.7	-2.5	-1.5	-1.7	-0.5	-2.2	-2.0
Age when periods started (menarche)	1.0	2.3	4.8	1.3	1.2	2.2	1.9	1.9	1.3	0.3	0.2	1.4	1.9
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.7	0.4	-0.2	1.1	0.2	1.3	0.4	-0.0	0.5	0.5	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.7	-1.4	-0.4	-1.0	-1.6	-0.6	-0.8	-1.4	-0.1	-0.3	0.8
Tinnitus: Yes, but not now, but have in the past	3.6	3.8	8.2	2.6	2.2	1.0	-0.4	0.8	2.9	2.4	1.9	2.6	0.7
Qualifications: CSEs or equivalent	1.0	1.3	3.6	0.8	-0.8	-0.8	-1.9	-1.1	1.7	1.2	1.5	0.4	0.2
Serious illness, injury or assault to yourself	0.2	0.3	0.6	-0.2	0.8	0.4	0.2	0.1	0.3	-0.7	-0.8	-0.7	0.3
High blood pressure	0.4	1.1	3.1	-0.0	-1.0	0.7	-0.2	1.2	-1.1	-0.8	1.8	-1.2	1.3
Hayfever, allergic rhinitis or eczema	1.5	3.3	6.0	-2.1	-2.0	-2.3	-1.5	-2.4	-2.2	-0.9	-1.2	-1.6	-1.2
Multivitamins +/- minerals	1.5	1.9	6.0	1.2	0.6	-0.4	-1.3	-0.7	2.5	2.2	0.8	1.5	-0.7
Stomach or abdominal pain in last month	0.4	0.4	2.0	0.3	-0.7	-0.4	-1.4	-0.5	-0.4	0.0	1.1	-0.2	0.2
Supplements: Glucosamine	0.9	1.2	4.6	-0.8	-1.3	-1.7	-2.1	-1.2	0.6	-0.2	0.6	0.1	-0.2
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.7	0.6	-0.3	0.5	0.9	0.5	0.2	0.8	0.2	0.4	-0.2
Medication: Atenolol	0.5	0.6	2.6	-0.8	-0.4	-0.8	0.4	-0.6	-1.6	-0.9	-0.9	-0.4	-0.4
Medication: Levothyroxine sodium	2.8	4.7	10.4	-2.9	-1.5	-1.0	1.1	-1.2	-2.5	-2.8	-3.2	-2.4	-1.5
Sitting height	0.5	3.8	11.1	-1.7	-1.2	-3.0	-3.3	-3.3	-0.6	-0.4	0.4	-0.7	-1.2
Chronic bronchitis/emphysema (father)	0.8	1.0	2.3	0.8	-0.7	1.1	-0.3	1.4	1.0	1.0	1.5	-0.1	1.0
High blood pressure (mother)	0.3	0.4	0.9	0.3	-1.0	-0.3	-0.6	-1.0	-0.4	0.5	-0.3	-0.5	-0.8
Body mass index (BMI)	0.9	3.7	11.4	-0.6	-3.4	2.0	-0.7	2.5	-2.5	-1.2	1.0	-0.8	2.4
Impedance of leg (left)	1.4	6.7	15.4	-2.5	-1.4	-3.9	-2.9	-3.9	-0.6	-1.6	-1.7	-2.3	-3.0
Leg predicted mass (left)	0.4	2.2	4.1	1.0	-1.7	2.0	-0.6	1.9	-0.9	0.9	1.8	1.5	1.7
Trunk fat mass	1.2	5.2	15.4	-1.5	-3.9	1.9	0.1	2.4	-3.7	-2.2	-0.1	-1.1	2.3
Waist circumference	1.0	3.7	9.8	-2.1	-2.7	1.0	-0.1	1.6	-3.1	-2.5	-0.9	-1.7	1.4
Number of incorrect matches in round	3.3	5.5	17.5	-3.2	1.1	-1.3	1.5	-1.0	-0.1	-3.5	-2.8	-4.2	-1.0
Past tobacco smoking	0.3	0.5	1.4	0.9	0.6	1.2	0.4	0.8	-0.1	0.9	0.9	0.2	0.6
Alcohol usually taken with meals	3.2	5.2	11.3	-3.4	0.2	-1.9	1.7	-1.5	-1.8	-3.1	-3.3	-2.5	-1.4
Nervous feelings	2.4	4.5	11.8	-1.5	-1.1	-3.4	-3.4	-3.0	-0.5	-1.3	-0.3	-1.6	-2.3
Frequency of tenseness / restlessness in last 2 weeks	3.5	5.4	27.8	0.4	-2.5	-2.8	-5.3	-2.3	-0.3	0.5	2.3	-0.4	-0.7
Hearing difficulty/problems with background noise	1.9	3.1	11.0	1.0	3.3	-0.8	-2.5	-0.4	1.3	0.4	1.6	2.2	1.6
Hair/balding pattern: Pattern 2	1.4	1.8	4.4	-1.4	-2.1	-0.4	0.3	-0.5	-1.6	-0.9	-1.2	-1.6	-1.9
Had menopause	0.3	0.4	1.2	-0.4	0.5	-0.9	-0.5	-1.1	0.9	-0.2	-0.0	-0.4	-0.4
Had other major operations	0.4	0.5	1.6	1.1	-1.3	0.5	-0.8	0.6	0.2	0.7	0.5	0.6	-0.3
Forced vital capacity (FVC)	0.1	0.4	1.3	0.8	0.4	-0.0	-0.7	-0.8	0.0	1.1	0.4	0.6	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	6.7	-2.6	0.0	-1.4	-1.4	-0.9	-1.3	-2.3	-1.1	-1.4	0.2
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	4.8	-0.5	0.8	-2.0	-1.7	-2.2	0.9	0.2	-0.1	0.1	-1.0
Qualifications: None of the above	0.4	0.8	2.1	0.3	-1.5	0.8	-0.5	1.1	0.4	0.4	1.4	-0.2	0.9
Financial difficulties in last 2 years	1.4	1.9	10.6	0.1	-1.4	-1.4	-3.3	-1.2	0.5	0.5	1.3	0.6	0.9
Mouth/teeth dental problems	1.1	1.7	4.5	-1.4	0.8	-2.1	-0.3	-1.5	-0.3	-1.1	-1.6	-1.0	-1.7
Heart attack	2.0	2.5	5.8	-1.5	-2.0	-1.0	-0.4	-0.6	-2.4	-2.4	-0.5	-2.4	0.0
Allergy	1.1	2.5	4.1	2.0	1.7	2.0	1.6	2.0	1.8	0.9	0.8	1.5	0.8
Pain all over the body in last month	1.4	1.5	3.5	-1.9	-1.2	-0.7	-0.5	-0.2	-1.6	-1.5	-1.5	-1.3	-0.9
Diabetes (self-reported)	1.1	1.7	6.6	-0.8	-2.6	-0.8	0.6	-1.0	-1.5	-0.4	-1.6	-1.0	-1.5
Hayfever/allergic rhinitis (self-reported)	4.1	5.4	11.3	-2.7	-1.4	-3.4	-1.7	-3.1	-1.6	-1.5	-1.8	-2.8	-2.2
Medication: Ramipril	0.7	0.9	2.0	-1.4	-1.3	-0.2	0.1	0.1	-1.3	-1.1	-1.2	-1.0	-0.3
Medication: Simvastatin	0.4	0.6	2.3	1.0	-1.2	0.5	0.5	0.5	0.3	1.5	0.5	0.4	-0.6
Fluid intelligence score	0.3	0.5	2.0	0.9	0.3	0.5	-0.1	0.1	0.2	1.4	0.2	1.0	-0.9
Illnesses of siblings	0.5	0.7	1.6	-1.0	0.5	-0.5	-0.1	-0.1	-1.1	-1.3	-0.6	-0.8	-1.1
Neuroticism score	1.4	3.0	13.4	-1.1	-1.4	-2.4	-3.7	-1.7	-0.8	-1.3	1.0	-1.3	-0.5
Weight	0.6	3.1	12.0	-0.8	-3.5	1.3	-1.5	1.5	-2.5	-1.1	1.0	-0.4	1.8
Impedance of arm (right)	0.3	1.5	9.6	0.0	1.3	0.6	3.1	0.6	0.2	-0.3	-1.4	0.9	0.1
Arm fat percentage (right)	1.4	5.4	13.3	-1.2	-3.7	2.3	1.0	2.9	-3.4	-2.1	-0.2	-1.1	2.6
Trunk fat-free mass	0.3	1.8	9.9	-0.1	-2.0	-0.7	-3.1	-0.7	-0.9	0.4	1.4	0.3	-0.1
Hip circumference	0.8	3.5	13.1	-0.3	-3.6	1.7	-0.6	2.3	-2.8	-0.8	1.0	0.3	1.9
Time employed in main current job	0.3	0.3	1.0	0.5	0.8	0.6	0.7	1.0	-0.5	-0.2	-0.1	0.4	-0.0
Alcohol intake versus 10 years previously	1.3	2.0	6.4	-1.3	-0.5	-0.0	0.9	0.5	-1.5	-2.5	-2.4	-1.5	-0.8
Father’s age at death	0.5	0.6	2.6	0.7	1.6	0.1	1.3	-0.1	0.6	0.7	0.0	0.9	0.2
Worrier / anxious feelings	4.0	7.5	19.9	-2.4	-1.0	-4.5	-2.6	-4.4	-0.6	-1.5	-1.5	-2.5	-3.4
Frequency of tiredness / lethargy in last 2 weeks	2.5	4.0	20.1	-0.1	-1.5	-2.5	-4.5	-2.8	0.6	0.0	1.5	0.0	-1.1
Falls in the last year	0.7	0.9	4.2	-0.3	-0.4	-1.2	-2.0	-1.4	0.4	0.2	0.8	0.7	0.2
Hair/balding pattern: Pattern 3	0.9	1.4	4.1	1.0	1.6	0.8	0.6	0.1	2.0	1.4	-0.4	1.8	0.2
Number of live births	1.4	2.0	4.8	-0.8	-2.1	-0.8	-2.2	-0.2	-0.8	-1.9	0.7	-2.2	0.5
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.8	1.6	0.0	1.2	-0.7	0.5	0.3	1.7	1.1	1.1	0.2
Pulse rate	1.8	3.0	6.7	2.0	1.9	2.6	0.9	2.4	0.2	1.2	1.4	1.8	1.7
Happiness	0.4	0.5	1.9	0.4	1.4	-0.2	0.6	-0.6	1.2	0.3	-0.3	0.8	0.1
Noisy workplace	0.6	0.8	2.0	0.2	0.6	1.4	0.8	1.4	1.4	-0.5	-0.7	0.4	0.4
Qualifications: A levels/AS levels or equivalent	0.5	1.1	4.6	0.9	2.1	0.5	1.3	0.3	1.3	1.2	-0.1	0.7	-0.5
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	4.4	-0.9	-1.2	0.0	0.9	-0.3	-1.1	-0.2	-2.1	-0.4	-1.7
Mouth/teeth dental problems: Dentures	0.7	1.2	4.7	-1.0	-2.2	0.7	-0.4	0.4	-1.0	-0.5	-0.4	-2.1	-0.2
Asthma	0.2	0.5	1.1	-0.4	0.7	-0.2	-1.0	0.3	-0.1	-0.6	1.1	0.2	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	3.9	-1.5	-0.1	-0.5	0.8	-0.5	-0.3	-0.4	-1.8	-1.0	-2.0
Medication: Cholesterol lowering	0.9	1.4	5.4	0.2	-2.3	-0.5	-1.3	-0.7	-1.9	0.4	0.2	-0.8	-1.5
Depression (self-reported)	1.0	1.2	3.5	-0.5	-1.2	-1.2	-1.9	-0.6	0.3	-0.1	1.6	-0.3	1.4
Medication: Lansoprazole	1.1	1.2	2.7	-1.1	-1.1	-1.4	0.1	-1.1	-1.0	-1.6	-0.6	-1.4	0.6
Prospective memory result	0.2	0.3	0.7	-0.7	0.4	-0.6	-0.3	-0.3	-0.3	-0.9	-0.6	-0.7	0.2
Lung cancer (father)	1.9	2.2	6.7	-1.7	-0.5	0.7	0.7	0.7	-2.6	-1.8	-2.1	-1.8	-0.5
Illnesses of mother	1.5	1.9	5.0	0.9	2.2	0.5	-0.2	1.1	2.0	0.8	1.3	1.4	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	5.5	2.3	0.2	1.6	-0.7	1.0	0.7	2.3	1.4	1.9	0.0
Pulse wave Arterial Stiffness index	0.3	0.3	0.9	0.2	-0.8	0.1	0.2	0.0	-0.6	0.4	-0.8	0.7	-0.9
Impedance of arm (left)	0.6	2.6	15.1	0.5	1.6	1.6	3.9	1.6	0.1	-0.0	-1.3	1.2	0.6
Arm fat mass (right)	1.1	4.4	17.2	-1.2	-4.2	1.7	-0.2	2.1	-3.0	-1.7	0.3	-1.2	2.0
Trunk predicted mass	0.3	1.8	10.1	-0.1	-1.9	-0.8	-3.2	-0.7	-0.9	0.4	1.4	0.3	-0.1
Standing height	0.1	1.3	3.9	-0.6	-0.8	-1.4	-2.0	-1.9	-0.3	0.2	0.2	0.6	-1.2
Length of working week for main job	1.2	1.3	2.9	-1.6	-0.7	-1.6	-0.6	-1.5	-0.8	-0.3	-1.2	-0.4	-1.7
Exposure to tobacco smoke at home	0.7	0.8	4.6	0.0	-0.7	0.6	-0.1	0.9	-2.1	-0.4	-0.3	0.8	0.7
Breastfed as a baby	1.0	1.3	6.9	0.6	2.6	0.3	1.2	0.6	1.1	0.2	-0.2	1.3	0.8
Tense / ‘highly strung’	0.9	1.6	9.5	-0.2	-0.1	-1.3	-3.1	-0.6	-0.8	-1.1	1.1	-0.8	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	3.3	5.1	26.2	-0.5	-2.1	-2.8	-5.1	-2.5	-0.2	-0.1	2.2	-0.9	0.6
Hair/balding pattern: Pattern 4	0.2	0.4	1.7	0.4	0.5	-0.3	0.1	-0.0	-1.3	-0.9	0.7	0.1	0.9
Birth weight of first child	0.4	0.7	1.8	-0.2	0.8	-1.4	-1.1	-1.2	0.4	0.5	0.3	0.5	-0.8
Peak expiratory flow (PEF)	0.1	0.3	0.7	0.3	-0.5	0.8	-0.8	0.5	-0.0	0.6	-0.3	0.8	-0.5
Pulse wave reflection index	2.6	3.3	7.5	-2.0	-1.1	-2.7	-0.9	-2.4	-1.5	-1.3	-2.0	-1.5	-1.9
Ever highly irritable/argumentative for 2 days	0.2	0.3	1.3	-0.8	-0.3	-0.4	-1.1	-0.3	0.6	-0.5	-0.0	-0.0	0.4
Loud music exposure frequency	1.4	1.5	3.9	1.4	-0.4	0.3	-1.9	0.1	1.3	1.4	2.0	1.3	0.8
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	4.3	-0.6	-1.1	-0.6	1.0	-0.7	-2.1	-0.4	-0.9	-1.2	-1.1
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	4.5	1.9	-0.5	2.1	1.4	1.4	0.2	1.3	1.2	2.0	2.0
Blood clot in the leg (DVT)	1.5	1.9	6.9	1.1	-1.2	0.7	-1.4	-0.5	1.8	2.6	0.7	1.9	0.0
Medication: Paracetamol	1.4	2.3	6.9	-1.9	-1.9	-0.9	-2.6	-1.1	-1.5	-0.9	-0.6	-1.4	-1.3
Headache pain in last month	0.9	1.6	7.8	-0.7	0.6	-0.9	-2.8	-1.3	-0.4	0.2	1.3	-0.2	1.5
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.9	0.2	2.0	0.1	1.3	-0.1	1.7	0.2	-0.6	0.7	0.4
Glaucoma (self-reported)	0.3	0.3	1.1	-0.4	0.6	0.1	0.6	0.1	-0.2	-1.1	-0.8	-0.2	-0.8
Gout (self-reported)	1.2	1.7	4.4	1.0	0.6	0.4	-1.5	0.1	1.4	1.5	1.7	2.1	1.3
Hypothyroidism/myxoedema (self-reported)	1.7	3.4	7.8	-2.3	-1.3	-0.4	1.5	-0.6	-2.2	-2.4	-2.8	-1.8	-1.5
Medication: Amlodipine	0.4	0.6	1.7	0.3	0.4	-1.1	-0.5	-1.3	-0.0	0.1	1.0	-0.5	-0.9
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.8	-0.3	1.2	1.1	-0.7	1.2	0.3	-0.6	1.0	-0.2	1.4
Birth weight	0.3	0.7	2.4	-0.5	1.5	0.3	1.4	0.8	-0.1	-0.7	-0.8	0.1	0.5
Chronic bronchitis/emphysema (mother)	0.8	0.9	3.0	0.3	-1.0	1.7	-0.3	1.6	0.2	0.1	0.8	-0.5	1.3
High blood pressure (siblings)	0.3	0.5	1.2	-0.9	0.0	-0.2	0.8	-0.2	-0.7	-1.1	-0.7	-1.0	0.4
Forced vital capacity (FVC), Best measure	0.2	0.8	2.5	1.4	0.6	0.3	-0.9	-0.4	0.2	1.6	0.8	1.1	-0.7
Body fat percentage	1.5	5.9	17.7	-1.8	-4.2	1.8	0.2	2.4	-3.8	-2.6	-0.6	-1.7	2.1
Leg fat percentage (right)	1.6	5.8	24.0	-2.1	-4.9	-0.1	-2.3	0.5	-3.3	-2.6	-0.2	-2.4	1.0
Arm fat-free mass (right)	0.5	2.3	11.2	-0.6	-2.6	-0.7	-3.4	-0.7	-1.3	-0.0	1.4	-0.4	0.0
Exposure to tobacco smoke outside home	0.7	0.9	3.4	0.7	-0.5	1.6	-0.8	1.8	-0.6	0.5	0.7	0.7	0.7
Comparative body size at age 10	1.3	3.5	7.7	1.3	2.5	2.1	0.2	2.0	0.1	1.3	2.1	2.3	2.8
Number of full brothers	0.5	0.7	1.8	1.3	-0.3	0.7	0.8	1.2	1.4	0.4	0.2	-0.4	-0.4
Worry too long after embarrassment	2.1	3.4	11.1	-0.6	-1.7	-3.1	-3.3	-2.6	-0.3	-0.1	1.3	-0.9	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	7.1	-0.1	-0.4	-1.2	-2.7	-0.8	0.6	0.0	1.0	-0.2	0.1
Wheeze or whistling in the chest in last year	0.5	0.8	2.8	0.1	0.1	-0.0	-1.1	0.9	0.5	-0.9	1.7	-0.1	1.5
Number of children fathered	1.6	1.9	4.3	-1.5	-0.4	-2.1	0.9	-1.5	-1.2	-0.8	-1.2	-1.9	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	2.4	2.8	5.4	-1.6	-2.2	-2.0	-0.6	-2.2	-0.9	-0.6	-1.6	-1.6	-2.3
Age at first live birth	1.3	2.2	8.5	-1.3	2.0	-0.2	2.2	-0.4	-0.3	-0.3	-2.9	0.2	-1.7
Pulse wave peak to peak time	0.3	0.3	0.6	-0.4	0.7	-0.2	-0.4	-0.3	0.5	-0.5	0.8	-0.8	0.7
Health satisfaction	0.7	0.9	2.3	-1.1	-0.5	-1.5	-1.2	-1.4	-0.3	-1.0	-0.7	-0.3	-0.5
Shortness of breath walking on level ground	0.8	0.9	2.3	-1.0	-1.1	-1.2	-1.0	-0.7	-0.3	-1.5	-0.0	-1.4	0.3
Qualifications: College or University degree	1.2	3.9	9.5	-2.4	0.2	-1.8	1.1	-2.1	-2.2	-1.7	-3.1	-1.0	-2.6
Eye problems/disorders: None of the above	0.9	1.0	3.0	1.1	0.4	-0.1	-1.3	-0.3	1.2	1.7	0.6	1.3	-0.7
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.3	-0.3	-0.5	-0.5	-0.2	-0.6	0.2	-0.5	-0.5	-0.3	-0.2
Emphysema/chronic bronchitis	3.3	3.7	9.5	-2.1	-1.5	-2.2	-0.1	-2.1	0.0	-1.8	-1.6	-3.1	-2.4
Medication for pain relief, constipation, heartburn	2.1	3.5	11.0	2.2	3.3	1.2	2.1	0.8	1.9	1.4	0.8	2.5	0.8
Neck or shoulder pain in last month	0.6	0.8	3.1	0.9	-1.7	0.3	-1.5	0.6	0.5	0.6	0.9	0.5	0.5
Medication: Blood pressure	0.6	1.1	2.3	-0.9	-1.1	-0.9	-1.4	-0.8	-1.5	-0.8	0.3	-1.5	-0.7
Angina (self-reported)	1.0	1.4	4.0	0.2	-1.8	0.2	-1.1	0.5	-2.0	-1.0	1.2	-1.5	0.5
Migraine (self-reported)	0.4	0.5	2.6	-0.7	0.1	0.6	0.2	0.9	0.1	-1.0	0.1	0.0	1.6
Medication: Ibuprofen	1.8	2.2	5.0	-2.2	-0.9	-1.0	0.1	-1.0	-0.9	-1.2	-2.1	-1.7	-2.2
Medication: Allopurinol	0.9	1.2	5.0	0.3	-0.1	-0.6	-2.2	-1.0	1.0	1.0	1.1	1.6	0.6
Medication: Omeprazole	1.0	1.2	5.2	-0.5	-0.9	-0.7	-2.3	-0.2	-1.3	-1.5	0.7	-0.3	0.5
Medication: Seretide 50 evohaler	8.1	9.4	15.9	-3.6	-2.7	-3.7	-1.4	-3.0	-0.6	-2.6	-3.1	-4.0	-4.0
Mean time to correctly identify matches	0.3	0.5	2.1	0.5	-0.7	0.5	-0.6	0.3	0.6	0.4	0.9	-0.5	1.4
Heart disease (mother)	0.3	0.4	1.5	-0.6	0.2	-0.0	0.7	-0.4	-0.3	-0.1	-1.2	0.3	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	2.2	0.1	-1.0	-0.1	0.9	-0.2	-0.3	-0.2	-0.6	-0.2	-1.5
Whole body fat mass	1.2	5.1	19.4	-1.8	-4.4	1.4	-0.7	1.8	-3.6	-2.2	-0.1	-1.4	1.8
Leg fat mass (right)	1.3	5.0	21.5	-1.5	-4.6	0.7	-2.2	1.1	-3.4	-1.9	0.5	-1.5	1.5
Arm predicted mass (right)	0.4	2.1	10.0	-0.6	-2.6	-0.5	-3.2	-0.5	-1.3	-0.2	1.3	-0.4	0.1
Pulse rate, automated reading	0.1	0.3	1.1	0.2	-1.0	0.6	-0.7	0.6	-0.7	-0.0	0.5	-0.2	0.5
Alcohol intake frequency.	0.3	0.7	2.8	0.5	-0.2	0.7	0.5	1.1	-0.3	-1.0	0.6	-0.7	1.7
Comparative height size at age 10	0.3	1.5	5.0	0.2	-1.4	-1.0	-1.8	-1.4	-0.4	0.9	0.2	1.1	-2.2
Number of full sisters	0.5	0.6	2.4	0.1	-0.9	0.3	-1.6	0.5	0.1	0.2	1.2	0.5	0.9
Suffer from ‘nerves’	1.4	2.3	6.8	-1.2	-0.5	-2.1	-2.6	-0.6	-1.3	-1.8	0.8	-1.9	-0.3
Overall health rating	0.3	0.6	3.6	0.4	-0.6	-0.1	-1.9	-0.0	1.0	0.1	0.9	0.0	0.3
Chest pain or discomfort	3.0	4.3	10.2	2.7	0.1	2.3	-0.1	2.7	1.4	1.1	3.2	1.6	2.7
Had major operations	0.7	0.9	3.3	1.1	0.2	1.0	-0.5	0.5	-0.5	1.4	0.3	1.8	0.5
Age at last live birth	1.1	1.6	5.7	-1.4	1.7	-0.4	2.0	0.2	-0.2	-1.3	-2.4	-0.4	-0.4
Family relationship satisfaction	1.6	2.0	7.1	1.8	0.8	0.9	0.4	1.0	2.7	1.7	1.1	1.7	0.7
Leg pain on walking	1.0	1.3	7.6	-0.1	-2.8	-1.2	-1.1	-1.1	-0.1	0.3	0.3	0.2	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.9	0.0	-1.0	0.3	-0.7	0.7	0.6	-0.1	0.4	-0.2	0.9
Commuting to job workplace: Car/motor vehicle	3.0	3.4	7.8	-1.8	-1.7	-2.6	-1.7	-2.1	-0.9	-1.7	0.3	-2.8	-1.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.0	0.6	1.4	0.9	0.9	1.1	0.6	0.0	0.8	-0.0	0.1
Medication: Aspirin	0.8	1.0	3.6	-0.7	-1.8	-0.1	-0.4	0.1	-1.9	-0.8	-0.2	-1.3	0.3
Supplements: Vitamin C	0.8	0.9	3.3	1.2	0.5	-0.2	-0.6	-0.1	1.8	1.8	0.6	0.1	-0.0
Knee pain experienced in last month	1.8	2.8	6.5	-1.6	-2.5	-1.9	-2.0	-1.9	-1.6	-1.2	0.1	-1.9	-0.4
Hypertension (Self-reported)	0.3	0.9	2.0	-0.2	-1.3	0.4	0.1	1.0	-1.1	-0.9	1.2	-1.4	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.9	-0.3	-1.3	-0.2	-0.9	-0.3	-1.7	-0.4	-0.7	0.6	-0.5
Illnesses of father: Heart disease	0.9	1.3	3.3	1.7	-0.0	1.8	1.1	1.6	0.7	1.3	0.8	0.5	-0.1
Illnesses of siblings: Diabetes	0.5	0.7	1.7	0.7	-1.3	0.7	-0.6	0.7	-0.1	0.1	1.0	0.8	1.1
Smoking status: Previous	0.6	1.0	2.2	-1.5	-0.0	-1.4	-0.2	-1.2	-0.5	-1.2	-1.3	-0.5	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	3.9	0.9	-1.1	0.8	-1.8	1.2	-2.0	-0.1	1.5	0.9	0.9
Whole body fat-free mass	0.2	1.4	5.0	0.3	-2.1	0.4	-2.2	0.4	-1.1	0.5	1.6	0.6	0.5
Leg fat-free mass (right)	0.4	2.2	5.1	1.0	-1.3	2.3	-0.1	2.2	-0.9	0.8	1.6	1.6	1.7
Arm fat percentage (left)	1.5	6.0	12.6	-0.9	-3.5	2.9	1.3	3.5	-3.4	-1.9	-0.1	-0.8	2.9
Average weekly red wine intake	0.5	0.7	2.7	-0.3	1.6	-0.8	1.1	-0.9	0.1	-0.9	-0.8	-0.2	-0.3
Handedness (chirality/laterality): Left-handed	2.0	2.4	7.4	1.4	2.3	-0.9	0.5	-1.3	2.7	1.8	0.3	1.4	-1.2
Mood swings	3.2	5.7	18.8	-2.1	-3.1	-2.8	-4.3	-2.2	-1.5	-1.9	0.1	-2.3	-0.8
Loneliness, isolation	0.0	0.1	0.2	0.2	0.2	0.2	0.2	-0.0	0.1	0.3	0.4	0.3	0.1
Long-standing illness, disability or infirmity	1.7	2.6	11.0	0.3	-3.3	-1.9	-2.7	-1.4	0.0	0.0	1.0	-0.9	-0.9
Ever had bowel cancer screening	0.2	0.2	1.0	-0.1	0.6	-0.0	-0.0	-0.5	0.1	0.3	-0.8	0.3	-1.0
Diabetes diagnosed by doctor	0.9	1.5	7.8	-0.6	-2.8	-0.7	0.3	-0.8	-1.1	-0.1	-1.2	-1.2	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	4.5	-0.9	-0.1	-2.1	0.1	-1.6	0.7	-0.3	-0.6	-0.8	-1.4
Friendships satisfaction	1.1	1.3	2.7	1.6	-0.3	1.2	1.2	0.3	1.3	1.6	0.3	1.4	-1.0
Qualifications: nursing, teaching	1.0	1.6	5.6	-0.8	-0.1	-2.0	-1.7	-2.4	-0.9	-0.3	0.4	-1.0	-0.8
Commuting to job workplace: Walk	0.6	0.7	2.9	-1.0	-0.2	-0.3	0.2	-0.6	-1.7	-0.6	-1.4	-0.0	-0.4
Eye problems/disorders: Cataract	0.5	0.6	1.7	-0.1	-0.2	1.1	1.2	1.3	0.2	-0.6	0.1	-0.4	1.0
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	5.0	1.5	1.9	1.6	-0.2	1.4	1.2	1.1	2.0	2.0	2.2
Medication for cholesterol	0.2	0.3	0.8	0.4	0.8	0.9	0.2	0.3	-0.2	0.3	-0.6	0.6	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.7	7.1	-1.2	0.4	-1.4	-2.7	-1.4	1.1	-0.6	0.4	-0.8	1.5
Back pain experienced in last month	1.8	2.6	14.3	0.3	-1.0	-1.5	-3.8	-1.4	1.3	1.4	1.3	0.9	-0.3
Mineral and other dietary supplements	0.7	0.9	2.3	0.6	-0.5	1.3	1.3	1.3	-1.5	-0.6	-0.9	-0.3	-0.3
Breast cancer (self-reported)	0.4	0.4	1.4	-0.0	-0.0	-0.4	-0.2	-0.9	0.6	0.9	-1.0	-0.1	-1.2
Asthma (self-reported)	0.2	0.4	1.4	-0.4	0.4	-0.4	-1.2	0.1	0.1	-0.5	1.1	0.1	0.9
Osteoporosis (self-reported)	0.1	0.2	0.4	0.4	0.1	0.5	0.3	0.6	-0.3	-0.1	0.4	0.6	0.3
Osteoarthritis (self-reported)	4.7	6.2	13.5	-2.9	-2.6	-2.6	-1.1	-2.2	-2.5	-2.8	-1.4	-3.7	-2.1
Medication: Aspirin	1.4	1.8	5.5	-1.0	-2.3	-0.6	-0.4	-0.4	-2.3	-1.2	-0.6	-2.0	-0.1
Medication: Gliclazide	0.7	0.8	3.3	-0.1	0.1	0.7	1.8	0.3	-1.2	0.0	-1.5	0.3	-0.8
Illnesses of father: None of the above (group 1)	3.1	3.9	7.1	-2.5	-0.6	-2.3	-1.1	-1.9	-2.7	-2.5	-2.3	-1.6	-0.6
Smoking status: Current	0.9	1.4	6.4	0.0	-2.5	-1.0	-1.9	-0.4	0.1	-0.5	0.2	-1.3	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	4.6	2.1	0.7	1.1	0.9	0.8	0.8	2.1	1.0	1.6	0.3
Whole body water mass	0.3	1.5	5.4	0.1	-2.1	0.2	-2.3	0.3	-1.1	0.4	1.6	0.5	0.6
Leg predicted mass (right)	0.4	2.3	5.3	1.0	-1.3	2.3	-0.1	2.3	-0.9	0.8	1.6	1.6	1.7
Arm fat mass (left)	1.1	4.5	15.5	-0.9	-3.9	2.0	-0.1	2.4	-3.1	-1.6	0.4	-0.9	2.3
Number of self-reported non-cancer illnesses	0.8	1.5	4.6	-0.6	-2.0	-1.3	-2.2	-1.1	-0.8	-0.7	0.6	-1.0	-0.4
Average weekly champagne plus white wine intake	1.9	2.6	6.0	-2.4	1.4	-0.7	1.7	-0.7	-1.5	-2.2	-2.4	-1.1	-0.7
Miserableness	2.5	4.3	11.6	-2.2	-1.0	-2.9	-3.4	-2.8	-1.3	-1.8	0.0	-2.0	-0.9
Guilty feelings	0.9	1.4	7.1	-0.7	-0.4	-1.6	-2.7	-1.2	0.5	-0.2	0.6	-1.1	-0.2
Wears glasses or contact lenses	1.4	1.6	5.9	-0.2	-0.8	1.3	2.2	0.6	-2.4	0.2	-1.7	0.2	-0.5
Ever taken oral contraceptive pill	0.4	0.4	1.8	-0.4	-0.8	-0.1	-0.3	0.1	-0.2	-1.1	0.0	-1.3	-0.3
Hearing aid user	0.3	0.3	1.2	0.2	0.1	0.6	0.4	0.8	-1.1	-0.5	-0.4	-0.4	0.2
Mother’s age at death	1.6	1.9	3.9	-1.8	0.2	-2.0	0.9	-1.7	-1.0	-1.5	-1.9	-1.1	-0.4
Financial situation satisfaction	1.4	1.8	4.6	1.9	1.0	0.1	-0.6	-0.6	1.2	2.2	1.6	1.9	0.3
Tinnitus: Yes, now most or all of the time	0.8	0.9	3.7	-0.6	-1.9	-1.2	-0.9	-0.8	0.6	-0.9	-0.2	-1.1	-0.1
Commuting to job workplace: Public transport	0.6	0.7	2.2	1.5	0.2	1.1	0.4	0.7	0.6	1.1	-0.3	0.8	-0.4
Eye problems/disorders: Glaucoma	0.3	0.4	1.0	-0.8	-0.1	-0.8	-0.5	-0.6	-0.1	-1.0	-0.1	-0.6	-0.6
Medication: Blood pressure	0.9	1.7	4.2	-1.2	-1.1	-0.4	-0.2	0.7	-1.3	-2.0	0.7	-2.0	1.7
Pain type(s) experienced in last month: Hip pain	1.0	1.3	7.1	0.7	-1.2	-0.5	-2.7	-0.5	-0.4	0.6	1.4	0.7	-0.1
Supplements: Fish oil (including cod liver oil)	1.0	1.4	4.3	-0.1	0.5	-1.1	-2.1	-0.9	1.4	0.7	1.8	0.4	1.0
High cholesterol (Self-reported)	0.3	0.5	1.5	1.2	0.4	0.6	0.6	0.6	-0.8	1.1	0.2	0.8	0.2
Medication: Bendroflumethiazide	1.0	1.6	4.3	-1.4	-2.1	-1.1	0.4	-0.7	-1.9	-1.0	-0.2	-1.7	-0.5
Medication: Paracetamol	1.6	2.5	5.9	-2.4	-1.5	-1.3	-2.4	-1.2	-1.3	-1.5	-0.8	-1.6	-1.2
Medication: Lisinopril	0.5	0.6	2.1	0.2	0.0	1.1	1.1	1.5	-0.5	-0.5	0.5	-0.7	0.5
Medication: Atorvastatin	0.7	0.8	3.4	-0.4	-0.7	-0.4	-0.2	-1.2	-1.8	-0.4	-1.1	-0.6	-1.0
Illnesses of father: High blood pressure	0.5	0.7	1.9	0.7	-0.4	0.4	1.4	0.5	1.3	0.9	0.9	0.1	0.6
Alcohol drinker status: Never	0.9	1.1	3.1	0.1	-1.0	-0.3	-0.5	0.5	-0.3	-0.9	1.8	-1.8	1.5
Ever smoked	0.6	1.0	2.9	-0.4	-0.5	-1.7	-1.1	-1.7	0.6	-0.3	-0.5	0.0	-1.3
Basal metabolic rate	0.3	1.7	6.2	0.1	-2.5	0.6	-2.1	0.7	-1.4	0.2	1.6	0.5	0.9
Leg fat percentage (left)	1.7	6.3	23.3	-2.3	-4.8	0.1	-2.0	0.7	-3.7	-2.8	-0.6	-2.5	0.9
Arm fat-free mass (left)	0.6	3.0	13.3	-0.9	-2.9	-1.2	-3.6	-1.1	-1.3	-0.5	1.2	-0.8	-0.2
Number of operations (self-reported)	0.8	1.2	4.8	1.1	-1.7	0.3	-2.2	0.1	-0.4	0.7	1.3	0.8	0.7
Average weekly beer plus cider intake	0.3	0.5	1.8	0.7	0.1	0.1	-1.4	0.3	0.4	0.5	1.3	0.5	0.3
Irritability	0.3	0.5	2.2	-0.6	-0.7	0.0	-1.5	0.6	-0.8	-0.8	0.0	0.2	0.6
Risk taking	0.7	1.1	2.1	1.5	-1.3	1.1	0.2	1.4	1.1	1.1	0.5	0.5	-0.8
Ever had prostate specific antigen (PSA) test	1.0	1.1	4.2	-1.4	-1.1	0.1	0.6	0.2	-0.7	-1.3	-2.0	-1.2	-0.0
Fractured/broken bones in last 5 years	0.4	0.5	1.5	0.9	0.4	0.9	0.6	1.0	1.2	0.3	0.5	0.2	0.4
Age started oral contraceptive pill	4.2	5.2	10.8	-2.7	-0.1	-1.9	-0.2	-1.8	-2.6	-2.6	-2.7	-2.5	-3.3
Diastolic blood pressure, automated reading	0.8	2.5	5.6	1.8	0.0	2.3	0.0	2.4	1.0	1.4	2.1	1.1	1.6
Ever depressed for a whole week	1.0	1.3	5.4	-0.7	-0.2	-1.7	-2.3	-1.8	0.3	-0.1	-0.3	-0.1	-0.8
Unable to work because of sickness or disability	0.4	0.5	1.8	0.8	-0.5	0.4	-1.1	0.7	0.4	0.4	1.3	0.5	0.5
Commuting to job workplace: Cycle	2.9	3.5	15.3	0.0	2.0	2.3	3.9	2.3	-0.4	-0.4	-0.9	1.1	1.7
Myopia	0.9	1.3	3.3	0.8	1.7	0.8	1.8	0.9	-0.5	0.0	-1.6	1.1	-1.0
Vascular/heart problems diagnosed by doctor	0.5	1.4	3.1	0.2	1.5	-0.4	0.6	-0.9	1.6	1.0	-1.8	1.5	-1.2
Cholesterol lowering medication	0.4	0.6	1.9	-0.9	-0.0	-0.8	0.8	-0.7	-0.4	-0.6	-1.4	-0.3	-0.7
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	5.9	-0.7	-1.5	-1.0	-2.4	-0.4	-1.4	-1.9	0.6	-0.8	0.7
Pain experienced in last month	0.8	1.4	5.4	1.0	2.3	1.4	1.5	1.2	0.6	0.1	-0.1	1.2	0.5
Supplements: Calcium	0.5	0.5	1.7	-0.2	-0.5	-1.3	0.5	-1.3	-0.4	-0.2	-0.6	-0.3	-0.9
Basal cell carcinoma (self-reported)	0.3	0.4	0.8	0.6	0.7	0.6	0.1	0.9	-0.7	-0.1	0.8	-0.0	0.8
Heart attack/myocardial infarction (self-reported)	1.5	1.9	5.1	-1.2	-1.8	-0.6	-0.0	-0.2	-2.3	-2.1	-0.4	-2.0	0.4
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	7.1	1.2	-1.5	0.6	-1.1	-0.6	1.6	2.7	0.4	1.7	-0.4
Heart disease (siblings)	2.3	2.8	7.1	2.5	-0.4	1.0	-1.1	0.1	2.7	2.7	1.9	1.2	0.2
Alcohol drinker status: Previous	0.6	0.6	1.2	-0.6	-0.9	-0.7	0.7	-0.6	-1.1	-0.4	-1.1	-0.7	-1.0
Pack years of smoking	1.0	1.5	4.6	1.6	-0.9	0.5	-1.1	0.4	1.2	2.1	1.4	1.5	0.0
Impedance of whole body	0.2	0.9	2.5	-1.0	0.2	-1.1	0.9	-1.1	-0.3	-0.8	-1.6	-0.5	-1.0
Leg fat mass (left)	1.3	5.1	21.0	-1.6	-4.6	0.7	-2.1	1.1	-3.6	-2.0	0.2	-1.6	1.3
Arm predicted mass (left)	0.5	2.4	12.3	-0.5	-2.5	-0.6	-3.5	-0.5	-1.2	-0.2	1.5	-0.4	0.1