Hub : Traits :

Frequency of tenseness / restlessness in last 2 weeks

349 significantly associated models · 39 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 43682052 45148674 1 1 1.4e-07 9.8e-07 0.130 90 TCAIM
2 3 48381826 50546340 9 1 1.0e-07 7.0e-07 0.028 80 GPX1
3 3 51616334 53015839 1 1 3.2e-07 2.0e-05 0.109 86 WDR82
4 3 135273949 137159572 2 1 2.7e-08 6.9e-08 1.000 100 PCCB
5 11 60403838 61815803 1 1 1.1e-07 2.8e-05 0.100 85 DAK
6 12 109295508 110704487 1 1 3.4e-08 4.8e-08 0.054 88 MMAB
7 13 31078511 32595740 1 1 4.6e-09 2.1e-06 0.177 92 B3GALTL
8 17 42607368 45796313 23 1 3.0e-14 6.8e-12 1.000 100 CRHR1-IT1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 4.08 1 1 3.0 0.00 1.0e+00 GPX1
Irritable Bowel Disease (IBD) 5.95 1 1 3.0 0.00 1.0e+00 GPX1
Ulcerative Colitis (UC) 5.25 1 1 3.0 0.00 1.0e+00 GPX1
Major Depression (MDD) 6.97 1 0 0.0 0.00 1.0e+00 GPX1
Reaction Time 2.16 1 0 0.0 0.00 1.0e+00 PCCB
Verbal and Numeric Reasoning (VNR) 6.30 3 1 3.0 0.00 1.0e+00 CRHR1-IT1 GPX1 WDR82
Breast Cancer 3.95 2 1 3.0 0.00 1.0e+00 CRHR1-IT1 GPX1
Ovarian Cancer 3.97 1 1 3.0 0.00 1.0e+00 CRHR1-IT1
Prostate Cancer 2.79 1 0 0.0 0.00 1.0e+00 GPX1
Age at First Birth 6.29 1 1 3.0 0.00 1.0e+00 GPX1
Bipolar Disorder 3.12 1 0 0.0 0.00 1.0e+00 WDR82
Crohns Disease (2012) 3.50 1 1 3.0 0.00 1.0e+00 GPX1
HDL Cholesterol 4.86 1 1 3.0 0.00 1.0e+00 MMAB
Neuroticism 8.65 2 1 3.0 0.00 1.0e+00 CRHR1-IT1 WDR82
Primary Biliary Cirrhosis 2.62 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Schizophrenia 4.57 3 1 3.0 0.00 1.0e+00 MMAB PCCB WDR82
Ulcerative Colitis 5.49 1 1 3.0 0.00 1.0e+00 GPX1
Blood Eosinophil Count 3.09 2 1 3.0 0.00 1.0e+00 CRHR1-IT1 WDR82
Blood Platelet Count 1.35 2 2 6.1 0.00 1.0e+00 PCCB WDR82
Blood Red Count 6.39 2 2 6.1 0.00 1.0e+00 CRHR1-IT1 WDR82
Blood White Count 1.37 3 1 3.0 0.00 1.0e+00 CRHR1-IT1 GPX1 PCCB
Heel T-Score 1.75 1 1 3.0 0.00 1.0e+00 CRHR1-IT1
BMI 3.14 2 1 3.0 0.00 1.0e+00 GPX1 WDR82
Height 1.57 4 4 12.1 0.46 5.4e-01 CRHR1-IT1 GPX1 PCCB WDR82
Waist Hip Ratio (WHR) 5.71 4 3 9.1 -0.36 6.4e-01 CRHR1-IT1 GPX1 PCCB WDR82
Systolic Blood Pressure 3.29 2 2 6.1 0.00 1.0e+00 CRHR1-IT1 GPX1
Smoking Status 3.56 2 1 3.0 0.00 1.0e+00 GPX1 WDR82
Cardiovascular Disease 1.46 1 0 0.0 0.00 1.0e+00 GPX1
Lung FEV1/FVC ratio 1.22 2 0 0.0 0.00 1.0e+00 CRHR1-IT1 GPX1
Lung FVC 5.73 2 2 6.1 0.00 1.0e+00 CRHR1-IT1 GPX1
Neuroticism 15.85 8 4 12.1 -0.98 3.1e-05 B3GALTL CRHR1-IT1 DAK GPX1 MMAB PCCB TCAIM WDR82
Hair Pigment 0.12 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Tanning 0.38 1 0 0.0 0.00 1.0e+00 WDR82
Hand grip strength (left) 1.86 1 1 3.0 0.00 1.0e+00 CRHR1-IT1
Number of treatments/medications taken 3.29 1 1 3.0 0.00 1.0e+00 GPX1
Sensitivity / hurt feelings 10.36 3 1 3.0 0.00 1.0e+00 CRHR1-IT1 MMAB PCCB
Frequency of depressed mood in last 2 weeks 9.50 3 0 0.0 0.00 1.0e+00 CRHR1-IT1 DAK PCCB
Hearing difficulty/problems: Yes 3.20 1 0 0.0 0.00 1.0e+00 MMAB
Relative age of first facial hair 7.07 1 1 3.0 0.00 1.0e+00 CRHR1-IT1
Systolic blood pressure, automated reading 3.98 2 2 6.1 0.00 1.0e+00 CRHR1-IT1 GPX1
Medication: Co-codamol 3.33 1 0 0.0 0.00 1.0e+00 GPX1
Pack years adult smoking proportion 3.25 1 0 0.0 0.00 1.0e+00 GPX1
Impedance of leg (right) 2.29 2 1 3.0 0.00 1.0e+00 CRHR1-IT1 GPX1
Leg fat-free mass (left) 1.08 1 0 0.0 0.00 1.0e+00 GPX1
Trunk fat percentage 2.17 2 2 6.1 0.00 1.0e+00 CRHR1-IT1 GPX1
Hand grip strength (right) 1.49 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Fed-up feelings 11.59 4 3 9.1 0.96 3.6e-02 CRHR1-IT1 DAK GPX1 PCCB
Frequency of unenthusiasm / disinterest in last 2 weeks 8.41 3 0 0.0 0.00 1.0e+00 DAK GPX1 PCCB
Relative age voice broke 5.17 1 1 3.0 0.00 1.0e+00 CRHR1-IT1
Taking other prescription medications 3.42 1 1 3.0 0.00 1.0e+00 GPX1
Age when periods started (menarche) 4.65 3 1 3.0 0.00 1.0e+00 CRHR1-IT1 GPX1 WDR82
Qualifications: CSEs or equivalent 3.62 1 0 0.0 0.00 1.0e+00 GPX1
High blood pressure 1.70 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Stomach or abdominal pain in last month 4.23 1 0 0.0 0.00 1.0e+00 PCCB
Sitting height 1.88 2 1 3.0 0.00 1.0e+00 CRHR1-IT1 WDR82
Body mass index (BMI) 3.42 1 1 3.0 0.00 1.0e+00 GPX1
Impedance of leg (left) 2.52 3 2 6.1 0.00 1.0e+00 CRHR1-IT1 GPX1 WDR82
Leg predicted mass (left) 1.05 1 0 0.0 0.00 1.0e+00 GPX1
Trunk fat mass 1.93 2 1 3.0 0.00 1.0e+00 CRHR1-IT1 GPX1
Waist circumference 1.62 1 1 3.0 0.00 1.0e+00 GPX1
Nervous feelings 9.83 3 3 9.1 0.00 1.0e+00 CRHR1-IT1 PCCB WDR82
Hearing difficulty/problems with background noise 3.70 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Hair/balding pattern: Pattern 2 3.16 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Forced vital capacity (FVC) 4.61 2 2 6.1 0.00 1.0e+00 CRHR1-IT1 GPX1
Ever unenthusiastic/disinterested for a whole week 4.62 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Qualifications: None of the above 4.70 1 1 3.0 0.00 1.0e+00 GPX1
Mouth/teeth dental problems 2.77 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Allergy 1.58 1 0 0.0 0.00 1.0e+00 MMAB
Pain all over the body in last month 3.90 1 0 0.0 0.00 1.0e+00 GPX1
Fluid intelligence score 5.62 2 1 3.0 0.00 1.0e+00 GPX1 PCCB
Neuroticism score 14.37 7 3 9.1 0.99 3.4e-05 B3GALTL CRHR1-IT1 DAK GPX1 MMAB PCCB WDR82
Weight 1.74 1 1 3.0 0.00 1.0e+00 GPX1
Impedance of arm (right) 4.69 3 2 6.1 0.00 1.0e+00 CRHR1-IT1 GPX1 WDR82
Arm fat percentage (right) 2.19 1 1 3.0 0.00 1.0e+00 GPX1
Trunk fat-free mass 1.11 1 0 0.0 0.00 1.0e+00 GPX1
Hip circumference 1.76 1 1 3.0 0.00 1.0e+00 GPX1
Time employed in main current job 2.38 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Alcohol intake versus 10 years previously 2.51 1 0 0.0 0.00 1.0e+00 GPX1
Father's age at death 2.91 1 0 0.0 0.00 1.0e+00 GPX1
Worrier / anxious feelings 9.74 4 3 9.1 0.99 6.6e-03 CRHR1-IT1 MMAB PCCB WDR82
Frequency of tiredness / lethargy in last 2 weeks 10.69 4 1 3.0 0.98 2.2e-02 GPX1 MMAB PCCB TCAIM
Falls in the last year 3.21 1 0 0.0 0.00 1.0e+00 MMAB
Hair/balding pattern: Pattern 3 7.03 1 1 3.0 0.00 1.0e+00 CRHR1-IT1
Forced expiratory volume in 1-second (FEV1) 5.26 2 2 6.1 0.00 1.0e+00 CRHR1-IT1 GPX1
Qualifications: A levels/AS levels or equivalent 6.59 2 1 3.0 0.00 1.0e+00 CRHR1-IT1 GPX1
Mouth/teeth dental problems: Dentures 2.87 1 0 0.0 0.00 1.0e+00 GPX1
Medication: Ibuprofen (e.g. Nurofen) 3.73 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Depression (self-reported) 4.27 1 0 0.0 0.00 1.0e+00 B3GALTL
Forced expiratory volume in 1-second (FEV1), Best measure 4.94 2 2 6.1 0.00 1.0e+00 CRHR1-IT1 GPX1
Impedance of arm (left) 5.70 4 2 6.1 -0.81 1.9e-01 CRHR1-IT1 GPX1 TCAIM WDR82
Arm fat mass (right) 2.33 1 1 3.0 0.00 1.0e+00 GPX1
Trunk predicted mass 1.08 1 0 0.0 0.00 1.0e+00 GPX1
Standing height 1.37 2 1 3.0 0.00 1.0e+00 GPX1 WDR82
Exposure to tobacco smoke at home 2.47 1 0 0.0 0.00 1.0e+00 GPX1
Tense / 'highly strung' 7.69 2 1 3.0 0.00 1.0e+00 PCCB WDR82
Seen doctor (GP) for nerves, anxiety, tension or depression 6.46 3 1 3.0 0.00 1.0e+00 B3GALTL TCAIM WDR82
Hair/balding pattern: Pattern 4 12.45 1 1 3.0 0.00 1.0e+00 CRHR1-IT1
Peak expiratory flow (PEF) 2.83 1 1 3.0 0.00 1.0e+00 CRHR1-IT1
Ever highly irritable/argumentative for 2 days 4.40 1 0 0.0 0.00 1.0e+00 GPX1
Qualifications: O levels/GCSEs or equivalent 2.71 1 0 0.0 0.00 1.0e+00 GPX1
Medication: Paracetamol 7.17 2 1 3.0 0.00 1.0e+00 CRHR1-IT1 GPX1
Headache pain in last month 7.83 1 1 3.0 0.00 1.0e+00 CRHR1-IT1
Forced vital capacity (FVC), Best measure 4.83 2 2 6.1 0.00 1.0e+00 CRHR1-IT1 GPX1
Body fat percentage 2.21 2 1 3.0 0.00 1.0e+00 CRHR1-IT1 GPX1
Leg fat percentage (right) 3.21 1 1 3.0 0.00 1.0e+00 GPX1
Arm fat-free mass (right) 1.46 1 1 3.0 0.00 1.0e+00 GPX1
Number of full brothers 3.61 1 0 0.0 0.00 1.0e+00 GPX1
Worry too long after embarrassment 8.43 3 1 3.0 0.00 1.0e+00 CRHR1-IT1 MMAB PCCB
Wheeze or whistling in the chest in last year 3.38 1 0 0.0 0.00 1.0e+00 GPX1
Age at first live birth 5.79 1 1 3.0 0.00 1.0e+00 GPX1
Health satisfaction 2.86 1 0 0.0 0.00 1.0e+00 GPX1
Qualifications: College or University degree 9.28 3 3 9.1 0.00 1.0e+00 B3GALTL CRHR1-IT1 GPX1
Medication for pain relief, constipation, heartburn 5.34 2 1 3.0 0.00 1.0e+00 CRHR1-IT1 GPX1
Neck or shoulder pain in last month 3.55 1 0 0.0 0.00 1.0e+00 GPX1
Medication: Ibuprofen 3.44 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Whole body fat mass 2.31 1 1 3.0 0.00 1.0e+00 GPX1
Leg fat mass (right) 2.90 1 1 3.0 0.00 1.0e+00 GPX1
Arm predicted mass (right) 1.52 1 1 3.0 0.00 1.0e+00 GPX1
Alcohol intake frequency. 3.26 2 1 3.0 0.00 1.0e+00 CRHR1-IT1 GPX1
Comparative height size at age 10 2.04 4 0 0.0 -0.57 4.3e-01 CRHR1-IT1 GPX1 PCCB WDR82
Suffer from 'nerves' 6.49 2 0 0.0 0.00 1.0e+00 CRHR1-IT1 WDR82
Overall health rating 4.90 1 1 3.0 0.00 1.0e+00 GPX1
Age at last live birth 5.19 1 1 3.0 0.00 1.0e+00 GPX1
Leg pain on walking 3.75 1 0 0.0 0.00 1.0e+00 GPX1
Hypertension (Self-reported) 1.55 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Whole body fat-free mass 1.09 1 1 3.0 0.00 1.0e+00 GPX1
Leg fat-free mass (right) 0.96 1 0 0.0 0.00 1.0e+00 GPX1
Arm fat percentage (left) 2.18 1 1 3.0 0.00 1.0e+00 GPX1
Handedness (chirality/laterality): Left-handed 3.31 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Mood swings 11.72 3 2 6.1 0.00 1.0e+00 CRHR1-IT1 GPX1 TCAIM
Loneliness, isolation 5.50 2 0 0.0 0.00 1.0e+00 CRHR1-IT1 GPX1
Qualifications: nursing, teaching 3.80 1 0 0.0 0.00 1.0e+00 GPX1
Mouth/teeth dental problems: Mouth ulcers 4.25 1 1 3.0 0.00 1.0e+00 CRHR1-IT1
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.47 1 1 3.0 0.00 1.0e+00 CRHR1-IT1
Whole body water mass 1.12 1 1 3.0 0.00 1.0e+00 GPX1
Leg predicted mass (right) 0.96 1 0 0.0 0.00 1.0e+00 GPX1
Arm fat mass (left) 2.24 1 1 3.0 0.00 1.0e+00 GPX1
Average weekly champagne plus white wine intake 3.85 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Miserableness 12.07 5 2 6.1 0.98 3.4e-03 B3GALTL CRHR1-IT1 GPX1 MMAB PCCB
Guilty feelings 7.23 2 1 3.0 0.00 1.0e+00 CRHR1-IT1 GPX1
Financial situation satisfaction 4.27 1 1 3.0 0.00 1.0e+00 GPX1
Medication: Blood pressure 2.66 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Medication: Paracetamol 6.98 2 1 3.0 0.00 1.0e+00 CRHR1-IT1 GPX1
Ever smoked 2.52 1 0 0.0 0.00 1.0e+00 WDR82
Basal metabolic rate 1.26 1 1 3.0 0.00 1.0e+00 GPX1
Leg fat percentage (left) 3.17 1 1 3.0 0.00 1.0e+00 GPX1
Arm fat-free mass (left) 1.77 1 1 3.0 0.00 1.0e+00 GPX1
Irritability 5.93 2 1 3.0 0.00 1.0e+00 CRHR1-IT1 MMAB
Risk taking 2.54 1 0 0.0 0.00 1.0e+00 PCCB
Age started oral contraceptive pill 2.53 1 0 0.0 0.00 1.0e+00 GPX1
Diastolic blood pressure, automated reading 3.06 2 1 3.0 0.00 1.0e+00 CRHR1-IT1 GPX1
Commuting to job workplace: Cycle 3.09 1 0 0.0 0.00 1.0e+00 TCAIM
Pain experienced in last month 6.07 3 1 3.0 0.00 1.0e+00 CRHR1-IT1 GPX1 MMAB
Pack years of smoking 2.50 1 0 0.0 0.00 1.0e+00 GPX1
Impedance of whole body 4.19 3 2 6.1 0.00 1.0e+00 CRHR1-IT1 GPX1 WDR82
Leg fat mass (left) 2.94 1 1 3.0 0.00 1.0e+00 GPX1
Arm predicted mass (left) 1.67 1 1 3.0 0.00 1.0e+00 GPX1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 9 0.2578 1.56
GTEx Adipose Visceral Omentum 6 0.2947 1.66
GTEx Adrenal Gland 5 0.3432 1.61
GTEx Artery Aorta 8 0.2687 1.64
GTEx Artery Coronary 12 1.0144 1.88
GTEx Artery Tibial 7 0.1861 1.56
GTEx Brain Caudate basal ganglia 4 0.4348 1.69
GTEx Brain Cerebellar Hemisphere 6 0.4030 1.67
GTEx Brain Cerebellum 7 0.3532 1.64
GTEx Brain Cortex 6 0.5797 1.70
GTEx Brain Frontal Cortex BA9 5 0.5411 1.84
GTEx Brain Hippocampus 5 0.9542 1.92
GTEx Brain Hypothalamus 4 0.6780 1.81
GTEx Brain Nucleus accumbens basal ganglia 6 0.6936 1.74
GTEx Brain Putamen basal ganglia 4 0.6410 1.68
GTEx Breast Mammary Tissue 8 0.4053 1.67
GTEx Breast Mammary Tissue (Male) 7 0.5868 1.58
GTEx Breast Mammary Tissue (Female) 8 0.4866 1.61
GTEx Cells EBV-transformed lymphocytes 11 0.7730 1.76
GTEx Cells Transformed fibroblasts 9 0.2143 1.57
GTEx Colon Sigmoid 8 0.5472 1.73
GTEx Colon Transverse 7 0.3391 1.67
GTEx Esophagus Gastroesophageal Junction 9 0.6228 1.72
GTEx Esophagus Mucosa 10 0.3012 1.58
GTEx Esophagus Muscularis 12 0.3713 1.67
GTEx Heart Atrial Appendage 6 0.3800 1.73
GTEx Heart Left Ventricle 6 0.3922 1.76
GTEx Liver 3 0.4184 1.80
GTEx Lung 11 0.3829 1.64
GTEx Muscle Skeletal 6 0.2076 1.58
GTEx Nerve Tibial 8 0.1851 1.54
GTEx Ovary 7 0.7709 1.93
GTEx Pancreas 7 0.4289 1.61
GTEx Pituitary 6 0.5381 1.85
GTEx Prostate 5 0.5988 1.74
GTEx Skin Not Sun Exposed Suprapubic 8 0.3253 1.68
GTEx Skin Sun Exposed Lower leg 12 0.3297 1.64
GTEx Small Intestine Terminal Ileum 4 0.8677 1.94
GTEx Spleen 7 0.4961 1.65
GTEx Stomach 9 0.6190 1.65
GTEx Testis 10 0.3170 1.63
GTEx Thyroid 12 0.3001 1.62
GTEx Uterus 6 1.0582 1.90
GTEx Vagina 4 0.6299 1.73
GTEx Whole Blood 4 0.2007 1.57
METSIM Adipose 1 0.0217 1.40
NTR Blood 3 0.1249 1.46
ROSMAP Brain Pre-frontal Cortex 2 0.0455 1.50
YFS Blood 1 0.0217 1.43
CommonMind Brain Pre-frontal Cortex 4 0.0744 1.44
TCGA Breast Tumor 1 0.1304 1.58
TCGA Breast Normal 3 0.0713 1.40
TCGA Ovarian Tumor 6 0.2053 1.46
TCGA Prostate Tumor 4 0.1156 1.44