Hub : Traits :

Maternal smoking around birth

20 significantly associated models · 12 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 43042125 44431715 1 1 3.2e-07 4.1e-09 0.0015 71 TMEM125
2 10 103550604 105282664 2 1 4.0e-11 1.1e-07 0.0302 83 ACTR1A
3 14 103161201 104892153 3 1 4.3e-08 1.7e-06 0.6790 99 KLC1
4 17 34146026 35644076 4 1 4.7e-08 2.6e-07 0.7500 100 GGNBP2
5 19 18533642 20117685 2 2 3.6e-09 1.5e-06 0.1370 90 SUGP1 TMEM161A

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 1.65 1 0 0.0 0.00 1.0000 KLC1
Irritable Bowel Disease (IBD) 1.14 1 0 0.0 0.00 1.0000 KLC1
Reaction Time 1.44 1 0 0.0 0.00 1.0000 ACTR1A
Verbal and Numeric Reasoning (VNR) 4.49 3 1 3.0 0.00 1.0000 ACTR1A GGNBP2 TMEM125
Age at First Birth 3.02 1 0 0.0 0.00 1.0000 SUGP1
Body Mass Index (BMI) (2010) 3.57 2 0 0.0 0.00 1.0000 GGNBP2 KLC1
LDL Cholesterol 2.49 1 0 0.0 0.00 1.0000 SUGP1
Neuroticism 2.81 1 0 0.0 0.00 1.0000 KLC1
Schizophrenia 5.45 4 1 3.0 1.00 0.0026 ACTR1A KLC1 SUGP1 TMEM125
Triglycerides 3.78 1 0 0.0 0.00 1.0000 SUGP1
Blood Eosinophil Count 1.27 4 0 0.0 -0.34 0.6580 GGNBP2 KLC1 SUGP1 TMEM161A
Blood Platelet Count 1.84 3 2 6.1 0.00 1.0000 KLC1 SUGP1 TMEM161A
Blood Red Count 2.11 2 1 3.0 0.00 1.0000 KLC1 TMEM125
Blood White Count 1.42 3 1 3.0 0.00 1.0000 ACTR1A TMEM125 TMEM161A
Heel T-Score 6.51 3 1 3.0 0.00 1.0000 ACTR1A KLC1 SUGP1
BMI 4.23 4 2 6.1 -0.94 0.0608 ACTR1A GGNBP2 KLC1 SUGP1
Height 1.69 6 3 9.1 0.76 0.0779 ACTR1A GGNBP2 KLC1 SUGP1 TMEM125 TMEM161A
Waist Hip Ratio (WHR) 1.38 2 0 0.0 0.00 1.0000 GGNBP2 SUGP1
Systolic Blood Pressure 2.32 2 1 3.0 0.00 1.0000 ACTR1A TMEM125
Smoking Status 10.21 3 1 3.0 0.00 1.0000 ACTR1A KLC1 TMEM125
Allergy or Eczema 2.67 1 0 0.0 0.00 1.0000 GGNBP2
Cardiovascular Disease 2.71 3 0 0.0 0.00 1.0000 GGNBP2 KLC1 TMEM125
Type 2 Diabetes (T2D) 2.89 1 0 0.0 0.00 1.0000 SUGP1
Lung FEV1/FVC ratio 1.56 2 1 3.0 0.00 1.0000 ACTR1A KLC1
Neuroticism 1.74 1 0 0.0 0.00 1.0000 ACTR1A
Hair Pigment 0.44 1 1 3.0 0.00 1.0000 KLC1
Hand grip strength (left) 3.61 1 1 3.0 0.00 1.0000 ACTR1A
Number of treatments/medications taken 2.58 2 0 0.0 0.00 1.0000 GGNBP2 SUGP1
Sensitivity / hurt feelings 1.85 1 0 0.0 0.00 1.0000 SUGP1
Systolic blood pressure, automated reading 2.11 1 0 0.0 0.00 1.0000 TMEM125
Eye problems/disorders: Diabetes related eye disease 2.31 1 0 0.0 0.00 1.0000 ACTR1A
Vitamin and mineral supplements 2.57 1 0 0.0 0.00 1.0000 ACTR1A
Medication: Co-codamol 1.89 1 0 0.0 0.00 1.0000 SUGP1
Pack years adult smoking proportion 4.92 2 0 0.0 0.00 1.0000 GGNBP2 KLC1
Impedance of leg (right) 3.18 3 2 6.1 0.00 1.0000 ACTR1A GGNBP2 KLC1
Leg fat-free mass (left) 2.50 3 1 3.0 0.00 1.0000 ACTR1A GGNBP2 KLC1
Trunk fat percentage 1.82 2 1 3.0 0.00 1.0000 GGNBP2 KLC1
Hand grip strength (right) 3.00 1 1 3.0 0.00 1.0000 ACTR1A
Townsend deprivation index at recruitment 2.67 1 0 0.0 0.00 1.0000 ACTR1A
Current tobacco smoking 6.86 3 1 3.0 0.00 1.0000 ACTR1A KLC1 SUGP1
Taking other prescription medications 2.24 1 0 0.0 0.00 1.0000 SUGP1
Age when periods started (menarche) 2.65 1 1 3.0 0.00 1.0000 TMEM125
Heel bone mineral density (BMD) T-score, automated (left) 4.18 1 1 3.0 0.00 1.0000 KLC1
High blood pressure 2.27 2 0 0.0 0.00 1.0000 KLC1 TMEM125
Hayfever, allergic rhinitis or eczema 2.98 2 0 0.0 0.00 1.0000 GGNBP2 SUGP1
Sitting height 0.79 2 0 0.0 0.00 1.0000 SUGP1 TMEM125
High blood pressure (mother) 2.53 1 0 0.0 0.00 1.0000 GGNBP2
Body mass index (BMI) 4.83 4 2 6.1 0.96 0.0449 ACTR1A GGNBP2 KLC1 SUGP1
Impedance of leg (left) 3.00 3 2 6.1 0.00 1.0000 ACTR1A GGNBP2 KLC1
Leg predicted mass (left) 2.47 3 1 3.0 0.00 1.0000 ACTR1A GGNBP2 KLC1
Trunk fat mass 2.18 3 1 3.0 0.00 1.0000 ACTR1A GGNBP2 KLC1
Waist circumference 3.98 4 1 3.0 0.93 0.0728 ACTR1A GGNBP2 KLC1 SUGP1
Past tobacco smoking 6.25 2 1 3.0 0.00 1.0000 ACTR1A KLC1
Alcohol usually taken with meals 4.82 2 0 0.0 0.00 1.0000 ACTR1A TMEM125
Nervous feelings 4.41 2 1 3.0 0.00 1.0000 ACTR1A KLC1
Hearing difficulty/problems with background noise 1.79 1 0 0.0 0.00 1.0000 KLC1
Forced vital capacity (FVC) 1.40 1 0 0.0 0.00 1.0000 GGNBP2
Heel bone mineral density (BMD) T-score, automated (right) 3.07 1 1 3.0 0.00 1.0000 KLC1
Qualifications: None of the above 5.95 4 0 0.0 0.99 0.0066 ACTR1A GGNBP2 SUGP1 TMEM125
Financial difficulties in last 2 years 3.37 1 0 0.0 0.00 1.0000 KLC1
Mouth/teeth dental problems 3.82 1 0 0.0 0.00 1.0000 KLC1
Fluid intelligence score 4.33 2 1 3.0 0.00 1.0000 GGNBP2 TMEM125
Illnesses of siblings 2.63 1 0 0.0 0.00 1.0000 SUGP1
Weight 2.69 3 2 6.1 0.00 1.0000 ACTR1A GGNBP2 KLC1
Impedance of arm (right) 3.91 4 1 3.0 -0.99 0.0086 ACTR1A GGNBP2 KLC1 SUGP1
Arm fat percentage (right) 3.15 2 2 6.1 0.00 1.0000 GGNBP2 KLC1
Trunk fat-free mass 1.72 1 1 3.0 0.00 1.0000 ACTR1A
Hip circumference 2.24 3 0 0.0 0.00 1.0000 ACTR1A GGNBP2 KLC1
Worrier / anxious feelings 4.62 2 1 3.0 0.00 1.0000 ACTR1A TMEM125
Frequency of tiredness / lethargy in last 2 weeks 2.76 1 0 0.0 0.00 1.0000 SUGP1
Number of live births 2.46 1 0 0.0 0.00 1.0000 SUGP1
Forced expiratory volume in 1-second (FEV1) 1.61 1 0 0.0 0.00 1.0000 ACTR1A
Qualifications: A levels/AS levels or equivalent 5.66 3 0 0.0 0.00 1.0000 ACTR1A SUGP1 TMEM125
Mouth/teeth dental problems: Dentures 2.99 2 0 0.0 0.00 1.0000 ACTR1A KLC1
Illnesses of mother 2.53 1 0 0.0 0.00 1.0000 GGNBP2
Impedance of arm (left) 3.99 4 1 3.0 -0.99 0.0104 ACTR1A GGNBP2 KLC1 SUGP1
Arm fat mass (right) 3.49 3 2 6.1 0.00 1.0000 ACTR1A GGNBP2 KLC1
Trunk predicted mass 1.74 1 1 3.0 0.00 1.0000 ACTR1A
Standing height 1.48 3 1 3.0 0.00 1.0000 KLC1 SUGP1 TMEM125
Exposure to tobacco smoke at home 4.36 1 0 0.0 0.00 1.0000 SUGP1
Birth weight of first child 2.11 1 0 0.0 0.00 1.0000 SUGP1
Peak expiratory flow (PEF) 2.18 1 0 0.0 0.00 1.0000 ACTR1A
Qualifications: O levels/GCSEs or equivalent 2.27 1 0 0.0 0.00 1.0000 GGNBP2
Medication: Paracetamol 4.19 2 0 0.0 0.00 1.0000 KLC1 SUGP1
Birth weight 2.12 1 0 0.0 0.00 1.0000 SUGP1
High blood pressure (siblings) 1.64 1 0 0.0 0.00 1.0000 KLC1
Forced vital capacity (FVC), Best measure 1.23 1 0 0.0 0.00 1.0000 SUGP1
Body fat percentage 2.41 2 1 3.0 0.00 1.0000 GGNBP2 KLC1
Leg fat percentage (right) 3.54 2 2 6.1 0.00 1.0000 GGNBP2 SUGP1
Arm fat-free mass (right) 2.22 2 1 3.0 0.00 1.0000 ACTR1A GGNBP2
Exposure to tobacco smoke outside home 3.39 1 0 0.0 0.00 1.0000 ACTR1A
Comparative body size at age 10 2.94 2 1 3.0 0.00 1.0000 GGNBP2 TMEM125
Worry too long after embarrassment 2.34 2 0 0.0 0.00 1.0000 ACTR1A TMEM125
Wheeze or whistling in the chest in last year 2.76 1 0 0.0 0.00 1.0000 KLC1
Age at first live birth 5.55 2 1 3.0 0.00 1.0000 SUGP1 TMEM161A
Qualifications: College or University degree 5.90 4 2 6.1 -0.98 0.0188 ACTR1A GGNBP2 SUGP1 TMEM125
Emphysema/chronic bronchitis 2.38 1 0 0.0 0.00 1.0000 KLC1
Medication for pain relief, constipation, heartburn 2.90 1 0 0.0 0.00 1.0000 SUGP1
Whole body fat mass 2.78 3 1 3.0 0.00 1.0000 ACTR1A GGNBP2 KLC1
Leg fat mass (right) 3.86 4 1 3.0 0.98 0.0236 ACTR1A GGNBP2 KLC1 SUGP1
Arm predicted mass (right) 2.26 2 1 3.0 0.00 1.0000 ACTR1A GGNBP2
Pulse rate, automated reading 1.13 1 0 0.0 0.00 1.0000 KLC1
Comparative height size at age 10 2.42 3 1 3.0 0.00 1.0000 KLC1 SUGP1 TMEM125
Suffer from 'nerves' 2.31 1 0 0.0 0.00 1.0000 ACTR1A
Overall health rating 3.91 2 0 0.0 0.00 1.0000 KLC1 SUGP1
Chest pain or discomfort 3.38 1 0 0.0 0.00 1.0000 SUGP1
Age at last live birth 3.14 1 0 0.0 0.00 1.0000 SUGP1
Qualifications: NVQ or HND or HNC or equivalent 2.37 1 0 0.0 0.00 1.0000 ACTR1A
Knee pain experienced in last month 1.99 1 0 0.0 0.00 1.0000 ACTR1A
Hypertension (Self-reported) 2.24 2 0 0.0 0.00 1.0000 KLC1 TMEM125
Illnesses of father: Heart disease 2.37 1 0 0.0 0.00 1.0000 TMEM125
Illnesses of siblings: Diabetes 2.05 1 0 0.0 0.00 1.0000 SUGP1
Smoking status: Previous 3.12 1 0 0.0 0.00 1.0000 ACTR1A
Whole body fat-free mass 2.00 2 1 3.0 0.00 1.0000 ACTR1A GGNBP2
Leg fat-free mass (right) 2.34 3 1 3.0 0.00 1.0000 ACTR1A GGNBP2 KLC1
Arm fat percentage (left) 2.89 2 1 3.0 0.00 1.0000 GGNBP2 KLC1
Friendships satisfaction 2.57 1 0 0.0 0.00 1.0000 ACTR1A
Qualifications: nursing, teaching 2.67 1 0 0.0 0.00 1.0000 ACTR1A
Medication for cholesterol 2.60 1 0 0.0 0.00 1.0000 GGNBP2
Mineral and other dietary supplements 3.04 1 0 0.0 0.00 1.0000 ACTR1A
Medication: Gliclazide 1.87 1 0 0.0 0.00 1.0000 SUGP1
Smoking status: Current 7.46 3 1 3.0 0.00 1.0000 ACTR1A KLC1 SUGP1
Whole body water mass 2.05 2 1 3.0 0.00 1.0000 ACTR1A GGNBP2
Leg predicted mass (right) 2.40 3 1 3.0 0.00 1.0000 ACTR1A GGNBP2 KLC1
Arm fat mass (left) 3.57 3 1 3.0 0.00 1.0000 ACTR1A GGNBP2 KLC1
Number of self-reported non-cancer illnesses 1.79 1 0 0.0 0.00 1.0000 KLC1
High cholesterol (Self-reported) 2.47 1 0 0.0 0.00 1.0000 SUGP1
Medication: Bendroflumethiazide 2.45 1 0 0.0 0.00 1.0000 TMEM125
Medication: Paracetamol 2.87 1 0 0.0 0.00 1.0000 SUGP1
Ever smoked 4.75 1 1 3.0 0.00 1.0000 ACTR1A
Basal metabolic rate 2.17 3 1 3.0 0.00 1.0000 ACTR1A GGNBP2 KLC1
Leg fat percentage (left) 3.75 3 2 6.1 0.00 1.0000 GGNBP2 KLC1 SUGP1
Arm fat-free mass (left) 2.40 2 1 3.0 0.00 1.0000 ACTR1A GGNBP2
Risk taking 3.47 1 0 0.0 0.00 1.0000 KLC1
Diastolic blood pressure, automated reading 4.17 4 0 0.0 0.53 0.4734 GGNBP2 KLC1 SUGP1 TMEM125
Unable to work because of sickness or disability 4.73 2 0 0.0 0.00 1.0000 SUGP1 TMEM125
Vascular/heart problems diagnosed by doctor 2.58 2 0 0.0 0.00 1.0000 KLC1 TMEM125
Pack years of smoking 4.83 1 0 0.0 0.00 1.0000 KLC1
Impedance of whole body 3.41 3 2 6.1 0.00 1.0000 ACTR1A GGNBP2 KLC1
Leg fat mass (left) 3.91 4 1 3.0 0.97 0.0302 ACTR1A GGNBP2 KLC1 SUGP1
Arm predicted mass (left) 2.45 2 1 3.0 0.00 1.0000 ACTR1A GGNBP2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.52
GTEx Adipose Visceral Omentum 1 0.0491 1.49
GTEx Adrenal Gland 0 0.0000 1.33
GTEx Artery Aorta 1 0.0336 1.46
GTEx Artery Coronary 1 0.0845 1.41
GTEx Artery Tibial 0 0.0000 1.50
GTEx Brain Caudate basal ganglia 0 0.0000 1.46
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.44
GTEx Brain Cerebellum 0 0.0000 1.53
GTEx Brain Cortex 0 0.0000 1.58
GTEx Brain Frontal Cortex BA9 0 0.0000 1.47
GTEx Brain Hippocampus 0 0.0000 1.32
GTEx Brain Hypothalamus 0 0.0000 1.35
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.47
GTEx Brain Putamen basal ganglia 0 0.0000 1.36
GTEx Breast Mammary Tissue 1 0.0507 1.47
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.42
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.35
GTEx Cells EBV-transformed lymphocytes 1 0.0703 1.48
GTEx Cells Transformed fibroblasts 0 0.0000 1.44
GTEx Colon Sigmoid 0 0.0000 1.32
GTEx Colon Transverse 0 0.0000 1.44
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.51
GTEx Esophagus Mucosa 0 0.0000 1.52
GTEx Esophagus Muscularis 1 0.0309 1.46
GTEx Heart Atrial Appendage 1 0.0633 1.43
GTEx Heart Left Ventricle 0 0.0000 1.44
GTEx Liver 1 0.1395 1.34
GTEx Lung 1 0.0348 1.46
GTEx Muscle Skeletal 2 0.0692 1.50
GTEx Nerve Tibial 0 0.0000 1.50
GTEx Ovary 0 0.0000 1.33
GTEx Pancreas 0 0.0000 1.45
GTEx Pituitary 0 0.0000 1.43
GTEx Prostate 0 0.0000 1.47
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.46
GTEx Skin Sun Exposed Lower leg 2 0.0549 1.48
GTEx Small Intestine Terminal Ileum 0 0.0000 1.47
GTEx Spleen 0 0.0000 1.46
GTEx Stomach 0 0.0000 1.43
GTEx Testis 0 0.0000 1.43
GTEx Thyroid 0 0.0000 1.49
GTEx Uterus 0 0.0000 1.42
GTEx Vagina 0 0.0000 1.28
GTEx Whole Blood 0 0.0000 1.41
METSIM Adipose 1 0.0217 1.48
NTR Blood 0 0.0000 1.49
ROSMAP Brain Pre-frontal Cortex 2 0.0455 1.49
YFS Blood 2 0.0433 1.44
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.47
TCGA Breast Tumor 0 0.0000 1.53
TCGA Breast Normal 0 0.0000 1.34
TCGA Ovarian Tumor 0 0.0000 1.42
TCGA Prostate Tumor 1 0.0289 1.48