Hub : Traits :

Irritability

552 significantly associated models · 85 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 43899918 45698128 1 1 8.9e-08 3.3e-08 1.0e-01 91 CAMKMT
2 3 48012797 50144951 10 1 7.2e-09 6.1e-09 1.0e+00 100 CCDC71
3 5 49462228 50836718 2 1 6.4e-08 9.3e-07 1.2e-01 90 PARP8
4 5 87104604 88677293 1 1 3.7e-08 6.8e-10 5.3e-03 80 LINC00461
5 7 11553163 12967449 1 1 1.7e-07 6.0e-08 1.4e-01 93 TMEM106B
6 8 8092025 13120332 34 1 6.9e-17 1.0e-17 6.5e-05 78 AF131215.9
7 12 15807367 17456908 1 1 7.8e-08 4.6e-05 3.6e-02 74 MGST1
8 13 110831451 112257226 1 1 1.5e-07 4.6e-06 1.0e+00 100 ANKRD10
9 16 29905882 31892919 9 1 8.5e-10 3.8e-10 1.0e+00 100 HSD3B7
10 16 70624483 72022941 1 1 2.9e-08 7.9e-08 1.3e-01 92 CMTR2
11 17 42774693 45796313 19 1 8.5e-10 1.4e-09 3.2e-01 97 RP11-259G18.1
12 20 32254831 34109427 3 1 2.1e-13 7.1e-12 8.3e-01 100 TP53INP2
13 22 40472399 42379813 2 1 9.1e-08 7.0e-09 2.5e-02 85 SLC25A17

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 2.72 1 0 0.0 0.00 1.0e+00 HSD3B7
Major Depression (MDD) 2.93 1 0 0.0 0.00 1.0e+00 TMEM106B
Verbal and Numeric Reasoning (VNR) 2.17 1 0 0.0 0.00 1.0e+00 LINC00461
Breast Cancer 2.16 1 1 3.0 0.00 1.0e+00 RP11-259G18.1
Ovarian Cancer 2.60 1 1 3.0 0.00 1.0e+00 RP11-259G18.1
LDL Cholesterol 1.69 1 0 0.0 0.00 1.0e+00 CMTR2
Lupus 2.37 1 0 0.0 0.00 1.0e+00 AF131215.9
Neuroticism 9.42 3 1 3.0 0.00 1.0e+00 AF131215.9 LINC00461 SLC25A17
Primary Biliary Cirrhosis 2.12 1 0 0.0 0.00 1.0e+00 RP11-259G18.1
Schizophrenia 2.23 1 0 0.0 0.00 1.0e+00 SLC25A17
Triglycerides 3.32 2 0 0.0 0.00 1.0e+00 HSD3B7 TP53INP2
Blood Eosinophil Count 2.33 3 3 9.1 0.00 1.0e+00 CCDC71 RP11-259G18.1 SLC25A17
Blood Platelet Count 0.58 1 1 3.0 0.00 1.0e+00 LINC00461
Blood Red Count 5.39 5 3 9.1 -0.61 2.7e-01 ANKRD10 CMTR2 HSD3B7 LINC00461 RP11-259G18.1
Blood White Count 0.67 2 0 0.0 0.00 1.0e+00 HSD3B7 LINC00461
Heel T-Score 2.42 4 2 6.1 0.34 6.6e-01 CCDC71 HSD3B7 RP11-259G18.1 SLC25A17
BMI 2.91 2 2 6.1 0.00 1.0e+00 HSD3B7 LINC00461
Height 2.00 5 5 15.2 0.78 1.2e-01 CAMKMT CMTR2 RP11-259G18.1 TMEM106B TP53INP2
Waist Hip Ratio (WHR) 1.80 1 1 3.0 0.00 1.0e+00 RP11-259G18.1
Systolic Blood Pressure 1.15 2 0 0.0 0.00 1.0e+00 CMTR2 RP11-259G18.1
Smoking Status 2.71 2 0 0.0 0.00 1.0e+00 CCDC71 RP11-259G18.1
Allergy or Eczema 1.73 1 1 3.0 0.00 1.0e+00 SLC25A17
Cardiovascular Disease 1.66 1 0 0.0 0.00 1.0e+00 HSD3B7
Lung FEV1/FVC ratio 1.45 2 0 0.0 0.00 1.0e+00 HSD3B7 RP11-259G18.1
Lung FVC 5.36 3 3 9.1 0.00 1.0e+00 HSD3B7 RP11-259G18.1 TP53INP2
Neuroticism 11.73 9 5 15.2 -0.94 1.4e-04 CCDC71 CMTR2 HSD3B7 LINC00461 PARP8 RP11-259G18.1 SLC25A17 TMEM106B TP53INP2
Hair Pigment 8.75 3 2 6.1 0.00 1.0e+00 RP11-259G18.1 SLC25A17 TP53INP2
Tanning 16.55 1 1 3.0 0.00 1.0e+00 TP53INP2
Hand grip strength (left) 3.26 2 1 3.0 0.00 1.0e+00 CAMKMT RP11-259G18.1
Sensitivity / hurt feelings 7.93 2 2 6.1 0.00 1.0e+00 AF131215.9 RP11-259G18.1
Frequency of depressed mood in last 2 weeks 5.75 3 1 3.0 0.00 1.0e+00 AF131215.9 RP11-259G18.1 TMEM106B
Relative age of first facial hair 5.67 1 1 3.0 0.00 1.0e+00 RP11-259G18.1
Systolic blood pressure, automated reading 2.98 2 1 3.0 0.00 1.0e+00 AF131215.9 RP11-259G18.1
Impedance of leg (right) 3.07 3 3 9.1 0.00 1.0e+00 AF131215.9 LINC00461 TP53INP2
Leg fat-free mass (left) 3.14 4 3 9.1 -0.63 3.7e-01 AF131215.9 CAMKMT LINC00461 TP53INP2
Trunk fat percentage 3.79 5 3 9.1 -0.40 5.1e-01 CCDC71 HSD3B7 LINC00461 RP11-259G18.1 SLC25A17
Hand grip strength (right) 2.55 2 1 3.0 0.00 1.0e+00 CAMKMT RP11-259G18.1
Current tobacco smoking 2.69 1 0 0.0 0.00 1.0e+00 SLC25A17
Fed-up feelings 7.71 6 2 6.1 0.99 3.3e-04 AF131215.9 ANKRD10 CMTR2 LINC00461 PARP8 RP11-259G18.1
Relative age voice broke 4.80 2 1 3.0 0.00 1.0e+00 RP11-259G18.1 TP53INP2
Age when periods started (menarche) 2.09 1 1 3.0 0.00 1.0e+00 CCDC71
Heel bone mineral density (BMD) T-score, automated (left) 4.55 2 1 3.0 0.00 1.0e+00 AF131215.9 CCDC71
High blood pressure 3.22 1 1 3.0 0.00 1.0e+00 AF131215.9
Medication: Levothyroxine sodium 1.85 1 0 0.0 0.00 1.0e+00 AF131215.9
Sitting height 3.71 3 3 9.1 0.00 1.0e+00 CAMKMT RP11-259G18.1 TP53INP2
Body mass index (BMI) 3.64 3 3 9.1 0.00 1.0e+00 AF131215.9 HSD3B7 LINC00461
Impedance of leg (left) 3.35 4 3 9.1 -0.08 9.2e-01 AF131215.9 LINC00461 RP11-259G18.1 TP53INP2
Leg predicted mass (left) 3.15 4 4 12.1 -0.63 3.7e-01 AF131215.9 CAMKMT LINC00461 TP53INP2
Trunk fat mass 3.76 3 3 9.1 0.00 1.0e+00 HSD3B7 LINC00461 RP11-259G18.1
Waist circumference 2.75 2 2 6.1 0.00 1.0e+00 HSD3B7 LINC00461
Past tobacco smoking 2.36 1 0 0.0 0.00 1.0e+00 RP11-259G18.1
Nervous feelings 8.79 5 2 6.1 0.96 7.8e-03 AF131215.9 HSD3B7 RP11-259G18.1 SLC25A17 TP53INP2
Frequency of tenseness / restlessness in last 2 weeks 6.95 2 1 3.0 0.00 1.0e+00 RP11-259G18.1 TMEM106B
Hair/balding pattern: Pattern 2 3.34 1 1 3.0 0.00 1.0e+00 RP11-259G18.1
Forced vital capacity (FVC) 4.40 2 2 6.1 0.00 1.0e+00 HSD3B7 RP11-259G18.1
Heel bone mineral density (BMD) T-score, automated (right) 4.58 2 1 3.0 0.00 1.0e+00 AF131215.9 CCDC71
Ever unenthusiastic/disinterested for a whole week 3.14 1 0 0.0 0.00 1.0e+00 RP11-259G18.1
Financial difficulties in last 2 years 2.15 1 0 0.0 0.00 1.0e+00 TMEM106B
Neuroticism score 15.41 9 7 21.2 0.97 1.8e-05 AF131215.9 ANKRD10 HSD3B7 LINC00461 PARP8 RP11-259G18.1 SLC25A17 TMEM106B TP53INP2
Weight 3.43 5 4 12.1 -0.49 4.0e-01 AF131215.9 CAMKMT HSD3B7 LINC00461 TP53INP2
Impedance of arm (right) 4.19 6 4 12.1 -0.15 7.8e-01 AF131215.9 CCDC71 LINC00461 RP11-259G18.1 TMEM106B TP53INP2
Arm fat percentage (right) 3.12 3 2 6.1 0.00 1.0e+00 AF131215.9 HSD3B7 LINC00461
Trunk fat-free mass 2.62 3 3 9.1 0.00 1.0e+00 AF131215.9 CAMKMT TP53INP2
Hip circumference 3.77 4 4 12.1 0.81 1.9e-01 AF131215.9 HSD3B7 LINC00461 TP53INP2
Time employed in main current job 3.14 1 0 0.0 0.00 1.0e+00 RP11-259G18.1
Worrier / anxious feelings 9.62 4 3 9.1 0.98 2.3e-02 AF131215.9 HSD3B7 RP11-259G18.1 SLC25A17
Frequency of tiredness / lethargy in last 2 weeks 4.63 2 1 3.0 0.00 1.0e+00 CCDC71 TMEM106B
Hair/balding pattern: Pattern 3 6.13 1 1 3.0 0.00 1.0e+00 RP11-259G18.1
Number of live births 1.75 1 0 0.0 0.00 1.0e+00 RP11-259G18.1
Forced expiratory volume in 1-second (FEV1) 5.07 2 2 6.1 0.00 1.0e+00 HSD3B7 RP11-259G18.1
Pulse rate 1.74 1 0 0.0 0.00 1.0e+00 CCDC71
Qualifications: A levels/AS levels or equivalent 1.56 1 0 0.0 0.00 1.0e+00 LINC00461
Mouth/teeth dental problems: Dentures 2.24 1 0 0.0 0.00 1.0e+00 TP53INP2
Asthma 1.57 1 0 0.0 0.00 1.0e+00 HSD3B7
Depression (self-reported) 3.32 1 0 0.0 0.00 1.0e+00 TMEM106B
Forced expiratory volume in 1-second (FEV1), Best measure 4.94 2 2 6.1 0.00 1.0e+00 HSD3B7 RP11-259G18.1
Impedance of arm (left) 4.09 5 4 12.1 -0.22 7.2e-01 AF131215.9 CCDC71 RP11-259G18.1 TMEM106B TP53INP2
Arm fat mass (right) 3.59 3 3 9.1 0.00 1.0e+00 AF131215.9 HSD3B7 LINC00461
Trunk predicted mass 2.65 3 2 6.1 0.00 1.0e+00 AF131215.9 CAMKMT TP53INP2
Standing height 2.17 4 3 9.1 -0.98 1.6e-02 CAMKMT RP11-259G18.1 TMEM106B TP53INP2
Tense / 'highly strung' 10.23 5 3 9.1 0.99 9.9e-04 AF131215.9 HSD3B7 SLC25A17 TMEM106B TP53INP2
Seen doctor (GP) for nerves, anxiety, tension or depression 5.37 1 1 3.0 0.00 1.0e+00 TMEM106B
Hair/balding pattern: Pattern 4 7.99 1 1 3.0 0.00 1.0e+00 RP11-259G18.1
Peak expiratory flow (PEF) 3.90 3 1 3.0 0.00 1.0e+00 AF131215.9 CAMKMT RP11-259G18.1
Qualifications: O levels/GCSEs or equivalent 2.06 1 0 0.0 0.00 1.0e+00 LINC00461
Blood clot in the leg (DVT) 2.38 1 0 0.0 0.00 1.0e+00 TP53INP2
Medication: Paracetamol 3.88 1 1 3.0 0.00 1.0e+00 RP11-259G18.1
Headache pain in last month 4.15 1 1 3.0 0.00 1.0e+00 RP11-259G18.1
Hypothyroidism/myxoedema (self-reported) 2.36 1 1 3.0 0.00 1.0e+00 AF131215.9
High blood pressure (siblings) 3.15 1 0 0.0 0.00 1.0e+00 TMEM106B
Forced vital capacity (FVC), Best measure 4.48 2 2 6.1 0.00 1.0e+00 HSD3B7 RP11-259G18.1
Body fat percentage 3.41 3 2 6.1 0.00 1.0e+00 HSD3B7 LINC00461 RP11-259G18.1
Leg fat percentage (right) 2.77 3 2 6.1 0.00 1.0e+00 AF131215.9 HSD3B7 LINC00461
Arm fat-free mass (right) 3.29 4 4 12.1 -0.70 3.0e-01 AF131215.9 CAMKMT LINC00461 TP53INP2
Comparative body size at age 10 3.46 5 1 3.0 -0.58 3.0e-01 AF131215.9 CAMKMT HSD3B7 LINC00461 TP53INP2
Number of full brothers 3.18 1 0 0.0 0.00 1.0e+00 RP11-259G18.1
Worry too long after embarrassment 6.81 5 1 3.0 0.99 1.9e-03 AF131215.9 ANKRD10 LINC00461 RP11-259G18.1 TP53INP2
Seen a psychiatrist for nerves, anxiety, tension or depression 4.10 1 0 0.0 0.00 1.0e+00 TMEM106B
Wheeze or whistling in the chest in last year 2.17 1 0 0.0 0.00 1.0e+00 HSD3B7
Age at first live birth 3.42 1 0 0.0 0.00 1.0e+00 AF131215.9
Qualifications: College or University degree 2.54 2 2 6.1 0.00 1.0e+00 LINC00461 RP11-259G18.1
Medication for pain relief, constipation, heartburn 3.34 1 1 3.0 0.00 1.0e+00 RP11-259G18.1
Neck or shoulder pain in last month 2.65 1 0 0.0 0.00 1.0e+00 CMTR2
Whole body fat mass 3.57 4 2 6.1 0.95 4.7e-02 AF131215.9 HSD3B7 LINC00461 RP11-259G18.1
Leg fat mass (right) 3.54 3 3 9.1 0.00 1.0e+00 AF131215.9 HSD3B7 LINC00461
Arm predicted mass (right) 3.35 5 3 9.1 -0.67 2.1e-01 AF131215.9 CAMKMT HSD3B7 LINC00461 TP53INP2
Pulse rate, automated reading 2.34 3 1 3.0 0.00 1.0e+00 CCDC71 HSD3B7 LINC00461
Alcohol intake frequency. 2.98 1 1 3.0 0.00 1.0e+00 RP11-259G18.1
Comparative height size at age 10 1.98 4 2 6.1 -0.69 3.1e-01 CAMKMT CMTR2 RP11-259G18.1 TP53INP2
Suffer from 'nerves' 5.25 1 1 3.0 0.00 1.0e+00 AF131215.9
Overall health rating 2.83 1 0 0.0 0.00 1.0e+00 HSD3B7
Leg pain on walking 2.18 1 0 0.0 0.00 1.0e+00 RP11-259G18.1
Supplements: Vitamin C 2.17 1 0 0.0 0.00 1.0e+00 RP11-259G18.1
Hypertension (Self-reported) 3.14 1 1 3.0 0.00 1.0e+00 AF131215.9
Illnesses of father: Heart disease 1.73 1 0 0.0 0.00 1.0e+00 RP11-259G18.1
Forced expiratory volume in 1-second (FEV1), predicted 1.62 1 1 3.0 0.00 1.0e+00 TP53INP2
Whole body fat-free mass 2.85 4 3 9.1 -0.71 2.9e-01 AF131215.9 CAMKMT LINC00461 TP53INP2
Leg fat-free mass (right) 3.02 4 3 9.1 -0.68 3.2e-01 AF131215.9 CAMKMT LINC00461 TP53INP2
Arm fat percentage (left) 3.48 3 2 6.1 0.00 1.0e+00 AF131215.9 HSD3B7 LINC00461
Handedness (chirality/laterality): Left-handed 3.17 1 1 3.0 0.00 1.0e+00 RP11-259G18.1
Mood swings 12.06 6 4 12.1 0.97 1.2e-03 AF131215.9 CMTR2 HSD3B7 RP11-259G18.1 SLC25A17 TMEM106B
Loneliness, isolation 5.52 2 0 0.0 0.00 1.0e+00 RP11-259G18.1 TMEM106B
Mouth/teeth dental problems: Mouth ulcers 3.00 1 1 3.0 0.00 1.0e+00 RP11-259G18.1
Asthma (self-reported) 1.57 1 0 0.0 0.00 1.0e+00 HSD3B7
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.72 2 2 6.1 0.00 1.0e+00 HSD3B7 RP11-259G18.1
Whole body water mass 2.89 4 3 9.1 -0.71 2.9e-01 AF131215.9 CAMKMT LINC00461 TP53INP2
Leg predicted mass (right) 3.03 4 3 9.1 -0.68 3.2e-01 AF131215.9 CAMKMT LINC00461 TP53INP2
Arm fat mass (left) 3.63 3 3 9.1 0.00 1.0e+00 AF131215.9 HSD3B7 LINC00461
Number of self-reported non-cancer illnesses 2.43 1 0 0.0 0.00 1.0e+00 TMEM106B
Average weekly champagne plus white wine intake 2.08 1 0 0.0 0.00 1.0e+00 RP11-259G18.1
Miserableness 7.85 4 3 9.1 0.99 9.5e-03 AF131215.9 CCDC71 RP11-259G18.1 TMEM106B
Guilty feelings 5.74 2 1 3.0 0.00 1.0e+00 AF131215.9 RP11-259G18.1
Medication: Blood pressure 2.87 2 1 3.0 0.00 1.0e+00 AF131215.9 RP11-259G18.1
High cholesterol (Self-reported) 2.19 1 0 0.0 0.00 1.0e+00 HSD3B7
Medication: Bendroflumethiazide 3.16 1 1 3.0 0.00 1.0e+00 AF131215.9
Medication: Paracetamol 3.69 1 1 3.0 0.00 1.0e+00 RP11-259G18.1
Basal metabolic rate 3.04 5 4 12.1 -0.63 2.6e-01 AF131215.9 CAMKMT HSD3B7 LINC00461 TP53INP2
Leg fat percentage (left) 2.78 3 2 6.1 0.00 1.0e+00 AF131215.9 HSD3B7 LINC00461
Arm fat-free mass (left) 3.14 4 3 9.1 -0.70 3.0e-01 AF131215.9 CAMKMT LINC00461 TP53INP2
Average weekly beer plus cider intake 2.76 1 0 0.0 0.00 1.0e+00 AF131215.9
Risk taking 2.73 1 0 0.0 0.00 1.0e+00 AF131215.9
Fractured/broken bones in last 5 years 3.03 1 0 0.0 0.00 1.0e+00 RP11-259G18.1
Diastolic blood pressure, automated reading 3.08 3 2 6.1 0.00 1.0e+00 AF131215.9 HSD3B7 LINC00461
Ever depressed for a whole week 4.31 1 0 0.0 0.00 1.0e+00 CCDC71
Vascular/heart problems diagnosed by doctor 2.80 1 1 3.0 0.00 1.0e+00 AF131215.9
Cholesterol lowering medication 1.59 1 0 0.0 0.00 1.0e+00 HSD3B7
Basal cell carcinoma (self-reported) 2.59 1 0 0.0 0.00 1.0e+00 TP53INP2
Deep venous thrombosis (DVT) (self-reported) 2.62 1 0 0.0 0.00 1.0e+00 TP53INP2
Impedance of whole body 4.20 5 5 15.2 -0.13 8.3e-01 AF131215.9 CCDC71 LINC00461 RP11-259G18.1 TP53INP2
Leg fat mass (left) 3.56 3 3 9.1 0.00 1.0e+00 AF131215.9 HSD3B7 LINC00461
Arm predicted mass (left) 3.37 5 3 9.1 -0.68 2.0e-01 AF131215.9 CAMKMT HSD3B7 LINC00461 TP53INP2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 14 0.4010 1.71
GTEx Adipose Visceral Omentum 10 0.4912 1.74
GTEx Adrenal Gland 9 0.6177 1.84
GTEx Artery Aorta 18 0.6046 1.73
GTEx Artery Coronary 12 1.0144 1.91
GTEx Artery Tibial 12 0.3191 1.66
GTEx Brain Caudate basal ganglia 6 0.6522 1.79
GTEx Brain Cerebellar Hemisphere 9 0.6044 1.86
GTEx Brain Cerebellum 9 0.4541 1.68
GTEx Brain Cortex 8 0.7729 1.87
GTEx Brain Frontal Cortex BA9 8 0.8658 1.91
GTEx Brain Hippocampus 4 0.7634 1.70
GTEx Brain Hypothalamus 4 0.6780 1.70
GTEx Brain Nucleus accumbens basal ganglia 8 0.9249 1.82
GTEx Brain Putamen basal ganglia 6 0.9615 1.86
GTEx Breast Mammary Tissue 10 0.5066 1.74
GTEx Breast Mammary Tissue (Male) 10 0.8382 1.64
GTEx Breast Mammary Tissue (Female) 8 0.4866 1.77
GTEx Cells EBV-transformed lymphocytes 11 0.7730 1.99
GTEx Cells Transformed fibroblasts 13 0.3096 1.68
GTEx Colon Sigmoid 11 0.7524 1.79
GTEx Colon Transverse 15 0.7267 1.79
GTEx Esophagus Gastroesophageal Junction 12 0.8304 1.86
GTEx Esophagus Mucosa 17 0.5120 1.77
GTEx Esophagus Muscularis 16 0.4950 1.79
GTEx Heart Atrial Appendage 9 0.5700 1.78
GTEx Heart Left Ventricle 9 0.5882 1.82
GTEx Liver 4 0.5579 1.77
GTEx Lung 17 0.5917 1.74
GTEx Muscle Skeletal 9 0.3114 1.70
GTEx Nerve Tibial 16 0.3703 1.65
GTEx Ovary 9 0.9912 1.88
GTEx Pancreas 14 0.8578 1.84
GTEx Pituitary 8 0.7175 1.83
GTEx Prostate 5 0.5988 1.77
GTEx Skin Not Sun Exposed Suprapubic 15 0.6100 1.82
GTEx Skin Sun Exposed Lower leg 17 0.4670 1.74
GTEx Small Intestine Terminal Ileum 6 1.3015 2.12
GTEx Spleen 7 0.4961 1.80
GTEx Stomach 10 0.6878 1.80
GTEx Testis 17 0.5388 1.78
GTEx Thyroid 19 0.4751 1.74
GTEx Uterus 9 1.5873 2.12
GTEx Vagina 6 0.9449 1.89
GTEx Whole Blood 8 0.4014 1.68
METSIM Adipose 5 0.1085 1.52
NTR Blood 7 0.2914 1.66
ROSMAP Brain Pre-frontal Cortex 24 0.5466 1.85
YFS Blood 4 0.0866 1.53
CommonMind Brain Pre-frontal Cortex 8 0.1488 1.64
TCGA Breast Tumor 3 0.3911 1.61
TCGA Breast Normal 7 0.1664 1.57
TCGA Ovarian Tumor 13 0.4449 1.67
TCGA Prostate Tumor 7 0.2024 1.67