Hub : Traits :

Medication: Paracetamol

350 significantly associated models · 32 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 173103273 174525917 1 1 1.1e-07 5.6e-09 1.0000 100 DARS2
2 1 242590540 244345666 2 1 1.1e-07 1.3e-07 1.0000 100 SDCCAG8
3 2 210489563 212026295 1 1 5.9e-08 3.2e-08 0.0022 69 AC007970.1
4 3 48618666 50448632 7 1 1.6e-08 4.0e-07 0.9550 100 USP4
5 6 96275538 97699026 1 1 1.2e-07 1.4e-08 0.0359 86 KIAA0776
6 12 56838745 58303535 1 1 9.1e-15 1.1e-14 1.0000 100 LRP1
7 17 42774693 45796313 19 1 2.8e-14 3.1e-14 1.0000 100 CRHR1-IT1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 3.06 1 1 3.0 0.00 1.0000 USP4
Irritable Bowel Disease (IBD) 4.88 1 1 3.0 0.00 1.0000 USP4
Ulcerative Colitis (UC) 5.07 1 1 3.0 0.00 1.0000 USP4
Major Depression (MDD) 2.55 1 0 0.0 0.00 1.0000 USP4
Reaction Time 1.26 1 0 0.0 0.00 1.0000 SDCCAG8
Verbal and Numeric Reasoning (VNR) 4.02 2 1 3.0 0.00 1.0000 CRHR1-IT1 USP4
Breast Cancer 3.88 1 1 3.0 0.00 1.0000 CRHR1-IT1
Ovarian Cancer 6.26 1 1 3.0 0.00 1.0000 CRHR1-IT1
Age at First Birth 3.92 1 0 0.0 0.00 1.0000 USP4
Neuroticism 6.90 2 1 3.0 0.00 1.0000 CRHR1-IT1 USP4
Primary Biliary Cirrhosis 4.34 2 0 0.0 0.00 1.0000 CRHR1-IT1 LRP1
Schizophrenia 2.95 1 1 3.0 0.00 1.0000 SDCCAG8
Ulcerative Colitis 5.04 1 1 3.0 0.00 1.0000 USP4
Blood Eosinophil Count 3.92 3 2 6.1 0.00 1.0000 CRHR1-IT1 LRP1 USP4
Blood Platelet Count 0.99 1 1 3.0 0.00 1.0000 CRHR1-IT1
Blood Red Count 7.70 2 2 6.1 0.00 1.0000 CRHR1-IT1 DARS2
Blood White Count 1.31 2 1 3.0 0.00 1.0000 CRHR1-IT1 USP4
Heel T-Score 2.36 2 1 3.0 0.00 1.0000 CRHR1-IT1 USP4
BMI 2.03 2 1 3.0 0.00 1.0000 LRP1 USP4
Height 1.60 4 4 12.1 0.11 0.8939 AC007970.1 CRHR1-IT1 LRP1 USP4
Waist Hip Ratio (WHR) 4.00 2 2 6.1 0.00 1.0000 CRHR1-IT1 USP4
Systolic Blood Pressure 2.95 3 2 6.1 0.00 1.0000 CRHR1-IT1 KIAA0776 SDCCAG8
Smoking Status 3.61 1 1 3.0 0.00 1.0000 USP4
Allergy or Eczema 2.22 1 0 0.0 0.00 1.0000 LRP1
Cardiovascular Disease 1.61 1 0 0.0 0.00 1.0000 SDCCAG8
Respiratory disease 4.30 1 1 3.0 0.00 1.0000 LRP1
Lung FEV1/FVC ratio 5.20 2 1 3.0 0.00 1.0000 CRHR1-IT1 LRP1
Lung FVC 7.27 2 1 3.0 0.00 1.0000 CRHR1-IT1 USP4
Neuroticism 11.35 3 2 6.1 0.00 1.0000 CRHR1-IT1 DARS2 USP4
Chronotype (morning person) 1.69 1 0 0.0 0.00 1.0000 USP4
Hair Pigment 0.21 2 0 0.0 0.00 1.0000 CRHR1-IT1 LRP1
Hand grip strength (left) 3.01 1 1 3.0 0.00 1.0000 CRHR1-IT1
Number of treatments/medications taken 7.52 3 0 0.0 0.00 1.0000 DARS2 LRP1 SDCCAG8
Sensitivity / hurt feelings 9.31 1 1 3.0 0.00 1.0000 CRHR1-IT1
Frequency of depressed mood in last 2 weeks 3.77 1 0 0.0 0.00 1.0000 CRHR1-IT1
Relative age of first facial hair 9.22 2 1 3.0 0.00 1.0000 CRHR1-IT1 DARS2
Systolic blood pressure, automated reading 3.98 3 1 3.0 0.00 1.0000 CRHR1-IT1 KIAA0776 USP4
Vitamin and mineral supplements 6.64 2 1 3.0 0.00 1.0000 CRHR1-IT1 LRP1
Medication: Co-codamol 3.92 1 0 0.0 0.00 1.0000 USP4
Pack years adult smoking proportion 3.77 1 0 0.0 0.00 1.0000 USP4
Impedance of leg (right) 1.32 2 0 0.0 0.00 1.0000 CRHR1-IT1 USP4
Trunk fat percentage 1.85 1 1 3.0 0.00 1.0000 CRHR1-IT1
Hand grip strength (right) 3.14 2 1 3.0 0.00 1.0000 CRHR1-IT1 LRP1
Current tobacco smoking 1.91 1 0 0.0 0.00 1.0000 USP4
Fed-up feelings 9.21 2 2 6.1 0.00 1.0000 CRHR1-IT1 USP4
Relative age voice broke 5.53 1 1 3.0 0.00 1.0000 CRHR1-IT1
Taking other prescription medications 3.78 1 0 0.0 0.00 1.0000 USP4
Age when periods started (menarche) 4.00 1 1 3.0 0.00 1.0000 USP4
High blood pressure 2.40 1 1 3.0 0.00 1.0000 SDCCAG8
Hayfever, allergic rhinitis or eczema 1.80 1 0 0.0 0.00 1.0000 LRP1
Multivitamins +/- minerals 3.57 1 0 0.0 0.00 1.0000 LRP1
Sitting height 3.38 2 2 6.1 0.00 1.0000 CRHR1-IT1 LRP1
Body mass index (BMI) 1.95 1 1 3.0 0.00 1.0000 USP4
Impedance of leg (left) 1.48 2 1 3.0 0.00 1.0000 CRHR1-IT1 USP4
Trunk fat mass 1.48 1 0 0.0 0.00 1.0000 CRHR1-IT1
Alcohol usually taken with meals 3.43 1 0 0.0 0.00 1.0000 DARS2
Nervous feelings 4.30 1 1 3.0 0.00 1.0000 CRHR1-IT1
Frequency of tenseness / restlessness in last 2 weeks 8.58 2 2 6.1 0.00 1.0000 CRHR1-IT1 USP4
Hearing difficulty/problems with background noise 2.78 1 0 0.0 0.00 1.0000 CRHR1-IT1
Hair/balding pattern: Pattern 2 3.17 1 0 0.0 0.00 1.0000 CRHR1-IT1
Forced vital capacity (FVC) 6.35 2 1 3.0 0.00 1.0000 CRHR1-IT1 USP4
Ever unenthusiastic/disinterested for a whole week 4.65 1 0 0.0 0.00 1.0000 CRHR1-IT1
Qualifications: None of the above 6.05 2 1 3.0 0.00 1.0000 SDCCAG8 USP4
Mouth/teeth dental problems 4.65 2 0 0.0 0.00 1.0000 CRHR1-IT1 SDCCAG8
Allergy 2.26 1 0 0.0 0.00 1.0000 LRP1
Pain all over the body in last month 4.16 1 0 0.0 0.00 1.0000 USP4
Hayfever/allergic rhinitis (self-reported) 3.25 1 0 0.0 0.00 1.0000 LRP1
Fluid intelligence score 3.59 1 0 0.0 0.00 1.0000 CRHR1-IT1
Neuroticism score 9.43 3 1 3.0 0.00 1.0000 CRHR1-IT1 DARS2 USP4
Weight 1.27 1 0 0.0 0.00 1.0000 USP4
Impedance of arm (right) 3.32 2 2 6.1 0.00 1.0000 CRHR1-IT1 USP4
Trunk fat-free mass 1.49 2 0 0.0 0.00 1.0000 DARS2 LRP1
Hip circumference 1.36 1 0 0.0 0.00 1.0000 USP4
Father's age at death 2.94 1 0 0.0 0.00 1.0000 USP4
Worrier / anxious feelings 3.66 1 1 3.0 0.00 1.0000 CRHR1-IT1
Frequency of tiredness / lethargy in last 2 weeks 6.91 2 1 3.0 0.00 1.0000 AC007970.1 USP4
Hair/balding pattern: Pattern 3 7.60 1 1 3.0 0.00 1.0000 CRHR1-IT1
Number of live births 2.35 1 0 0.0 0.00 1.0000 CRHR1-IT1
Forced expiratory volume in 1-second (FEV1) 7.29 2 2 6.1 0.00 1.0000 CRHR1-IT1 USP4
Noisy workplace 2.78 1 0 0.0 0.00 1.0000 CRHR1-IT1
Qualifications: A levels/AS levels or equivalent 6.89 3 2 6.1 0.00 1.0000 CRHR1-IT1 SDCCAG8 USP4
Asthma 3.27 1 0 0.0 0.00 1.0000 LRP1
Medication: Ibuprofen (e.g. Nurofen) 12.53 3 1 3.0 0.00 1.0000 CRHR1-IT1 KIAA0776 LRP1
Forced expiratory volume in 1-second (FEV1), Best measure 7.20 2 2 6.1 0.00 1.0000 CRHR1-IT1 USP4
Impedance of arm (left) 4.05 2 2 6.1 0.00 1.0000 CRHR1-IT1 USP4
Arm fat mass (right) 1.43 1 0 0.0 0.00 1.0000 USP4
Trunk predicted mass 1.47 2 0 0.0 0.00 1.0000 DARS2 LRP1
Standing height 1.52 3 2 6.1 0.00 1.0000 CRHR1-IT1 LRP1 USP4
Tense / 'highly strung' 4.98 1 1 3.0 0.00 1.0000 DARS2
Hair/balding pattern: Pattern 4 14.23 1 1 3.0 0.00 1.0000 CRHR1-IT1
Peak expiratory flow (PEF) 3.61 1 1 3.0 0.00 1.0000 CRHR1-IT1
Qualifications: O levels/GCSEs or equivalent 4.72 1 0 0.0 0.00 1.0000 USP4
Medication: Paracetamol 24.27 7 6 18.2 0.91 0.0045 AC007970.1 CRHR1-IT1 DARS2 KIAA0776 LRP1 SDCCAG8 USP4
Headache pain in last month 34.62 6 4 12.1 0.65 0.1620 AC007970.1 CRHR1-IT1 DARS2 KIAA0776 LRP1 SDCCAG8
Medication: Amlodipine 2.76 1 0 0.0 0.00 1.0000 SDCCAG8
Medication: Ventolin 100micrograms inhaler 3.85 1 0 0.0 0.00 1.0000 AC007970.1
Forced vital capacity (FVC), Best measure 6.39 2 1 3.0 0.00 1.0000 CRHR1-IT1 USP4
Body fat percentage 1.76 1 0 0.0 0.00 1.0000 LRP1
Leg fat percentage (right) 2.43 2 0 0.0 0.00 1.0000 LRP1 USP4
Arm fat-free mass (right) 1.35 1 0 0.0 0.00 1.0000 USP4
Exposure to tobacco smoke outside home 4.18 1 0 0.0 0.00 1.0000 SDCCAG8
Number of full brothers 3.10 1 0 0.0 0.00 1.0000 USP4
Worry too long after embarrassment 3.62 1 0 0.0 0.00 1.0000 CRHR1-IT1
Age at first live birth 5.08 1 1 3.0 0.00 1.0000 USP4
Qualifications: College or University degree 9.17 5 3 9.1 -0.23 0.7151 AC007970.1 CRHR1-IT1 DARS2 SDCCAG8 USP4
Medication for pain relief, constipation, heartburn 18.78 6 5 15.2 -0.76 0.0799 AC007970.1 CRHR1-IT1 DARS2 KIAA0776 LRP1 SDCCAG8
Neck or shoulder pain in last month 4.75 1 0 0.0 0.00 1.0000 USP4
Migraine (self-reported) 19.67 2 2 6.1 0.00 1.0000 KIAA0776 LRP1
Medication: Ibuprofen 9.99 2 1 3.0 0.00 1.0000 CRHR1-IT1 LRP1
Whole body fat mass 1.55 1 0 0.0 0.00 1.0000 USP4
Leg fat mass (right) 1.97 1 0 0.0 0.00 1.0000 USP4
Arm predicted mass (right) 1.42 1 0 0.0 0.00 1.0000 USP4
Pulse rate, automated reading 1.84 1 0 0.0 0.00 1.0000 DARS2
Alcohol intake frequency. 4.44 2 1 3.0 0.00 1.0000 CRHR1-IT1 LRP1
Comparative height size at age 10 1.21 1 1 3.0 0.00 1.0000 CRHR1-IT1
Overall health rating 6.92 3 2 6.1 0.00 1.0000 AC007970.1 SDCCAG8 USP4
Chest pain or discomfort 2.52 1 0 0.0 0.00 1.0000 USP4
Age at last live birth 4.10 1 0 0.0 0.00 1.0000 USP4
Illness, injury, bereavement, stress in last 2 years 3.39 1 0 0.0 0.00 1.0000 AC007970.1
Knee pain experienced in last month 5.09 2 0 0.0 0.00 1.0000 DARS2 SDCCAG8
Hypertension (Self-reported) 2.26 1 0 0.0 0.00 1.0000 SDCCAG8
Handedness (chirality/laterality): Left-handed 3.55 1 0 0.0 0.00 1.0000 CRHR1-IT1
Mood swings 9.65 2 2 6.1 0.00 1.0000 CRHR1-IT1 USP4
Loneliness, isolation 4.22 2 0 0.0 0.00 1.0000 CRHR1-IT1 USP4
Qualifications: nursing, teaching 4.08 1 0 0.0 0.00 1.0000 SDCCAG8
Mouth/teeth dental problems: Mouth ulcers 5.34 1 1 3.0 0.00 1.0000 CRHR1-IT1
Mineral and other dietary supplements 3.23 1 0 0.0 0.00 1.0000 LRP1
Asthma (self-reported) 3.39 1 0 0.0 0.00 1.0000 LRP1
Smoking status: Current 1.81 1 0 0.0 0.00 1.0000 USP4
Forced expiratory volume in 1-second (FEV1), predicted percentage 6.54 1 1 3.0 0.00 1.0000 CRHR1-IT1
Arm fat mass (left) 1.31 1 0 0.0 0.00 1.0000 USP4
Average weekly champagne plus white wine intake 4.19 1 0 0.0 0.00 1.0000 CRHR1-IT1
Miserableness 10.23 3 2 6.1 0.00 1.0000 CRHR1-IT1 SDCCAG8 USP4
Guilty feelings 3.86 1 0 0.0 0.00 1.0000 CRHR1-IT1
Mother's age at death 3.08 1 0 0.0 0.00 1.0000 SDCCAG8
Financial situation satisfaction 3.33 1 0 0.0 0.00 1.0000 USP4
Medication: Blood pressure 2.42 1 0 0.0 0.00 1.0000 CRHR1-IT1
Supplements: Fish oil (including cod liver oil) 3.04 1 0 0.0 0.00 1.0000 LRP1
Ever smoked 2.08 1 0 0.0 0.00 1.0000 USP4
Leg fat percentage (left) 2.41 2 0 0.0 0.00 1.0000 LRP1 USP4
Arm fat-free mass (left) 1.64 1 0 0.0 0.00 1.0000 USP4
Irritability 5.13 2 1 3.0 0.00 1.0000 CRHR1-IT1 USP4
Risk taking 2.44 1 0 0.0 0.00 1.0000 SDCCAG8
Diastolic blood pressure, automated reading 5.82 1 1 3.0 0.00 1.0000 SDCCAG8
Myopia 4.44 1 0 0.0 0.00 1.0000 LRP1
Vascular/heart problems diagnosed by doctor 2.07 1 0 0.0 0.00 1.0000 SDCCAG8
Pain experienced in last month 11.89 5 1 3.0 -0.49 0.4074 AC007970.1 CRHR1-IT1 DARS2 LRP1 USP4
Pack years of smoking 3.05 1 0 0.0 0.00 1.0000 USP4
Impedance of whole body 3.21 2 2 6.1 0.00 1.0000 CRHR1-IT1 USP4
Leg fat mass (left) 2.00 1 0 0.0 0.00 1.0000 USP4
Arm predicted mass (left) 1.60 2 0 0.0 0.00 1.0000 DARS2 USP4

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 9 0.2578 1.59
GTEx Adipose Visceral Omentum 6 0.2947 1.67
GTEx Adrenal Gland 5 0.3432 1.62
GTEx Artery Aorta 9 0.3023 1.67
GTEx Artery Coronary 9 0.7608 1.96
GTEx Artery Tibial 6 0.1595 1.64
GTEx Brain Caudate basal ganglia 5 0.5435 1.56
GTEx Brain Cerebellar Hemisphere 6 0.4030 1.64
GTEx Brain Cerebellum 7 0.3532 1.68
GTEx Brain Cortex 6 0.5797 1.70
GTEx Brain Frontal Cortex BA9 6 0.6494 1.73
GTEx Brain Hippocampus 4 0.7634 1.85
GTEx Brain Hypothalamus 4 0.6780 1.77
GTEx Brain Nucleus accumbens basal ganglia 6 0.6936 1.75
GTEx Brain Putamen basal ganglia 6 0.9615 1.90
GTEx Breast Mammary Tissue 8 0.4053 1.66
GTEx Breast Mammary Tissue (Male) 7 0.5868 1.69
GTEx Breast Mammary Tissue (Female) 7 0.4258 1.70
GTEx Cells EBV-transformed lymphocytes 9 0.6325 1.74
GTEx Cells Transformed fibroblasts 11 0.2620 1.58
GTEx Colon Sigmoid 9 0.6156 1.78
GTEx Colon Transverse 8 0.3876 1.68
GTEx Esophagus Gastroesophageal Junction 8 0.5536 1.73
GTEx Esophagus Mucosa 10 0.3012 1.60
GTEx Esophagus Muscularis 13 0.4022 1.63
GTEx Heart Atrial Appendage 8 0.5066 1.57
GTEx Heart Left Ventricle 7 0.4575 1.64
GTEx Liver 4 0.5579 1.62
GTEx Lung 11 0.3829 1.63
GTEx Muscle Skeletal 8 0.2768 1.59
GTEx Nerve Tibial 11 0.2546 1.52
GTEx Ovary 6 0.6608 1.91
GTEx Pancreas 7 0.4289 1.69
GTEx Pituitary 5 0.4484 1.73
GTEx Prostate 4 0.4790 1.81
GTEx Skin Not Sun Exposed Suprapubic 8 0.3253 1.72
GTEx Skin Sun Exposed Lower leg 9 0.2473 1.65
GTEx Small Intestine Terminal Ileum 4 0.8677 1.88
GTEx Spleen 6 0.4252 1.65
GTEx Stomach 8 0.5502 1.78
GTEx Testis 10 0.3170 1.62
GTEx Thyroid 11 0.2751 1.57
GTEx Uterus 6 1.0582 2.02
GTEx Vagina 5 0.7874 1.89
GTEx Whole Blood 6 0.3011 1.62
METSIM Adipose 1 0.0217 1.43
NTR Blood 4 0.1665 1.49
ROSMAP Brain Pre-frontal Cortex 1 0.0228 1.47
YFS Blood 0 0.0000 1.36
CommonMind Brain Pre-frontal Cortex 3 0.0558 1.44
TCGA Breast Tumor 2 0.2608 1.42
TCGA Breast Normal 2 0.0475 1.36
TCGA Ovarian Tumor 5 0.1711 1.44
TCGA Prostate Tumor 4 0.1156 1.42