Hub : Traits :

Ulcerative Colitis

167 significantly associated models · 69 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 1781220 3261925 6 1 7.9e-10 8.0e-10 2.2e-02 86 RP3-395M20.9
2 1 7314655 8738937 1 1 3.2e-08 2.3e-09 1.8e-02 84 PARK7
3 1 19515061 21114833 2 4 1.5e-23 4.9e-31 2.4e-05 87 OTUD3 PLA2G5
4 1 160642451 162039394 1 1 1.3e-07 3.8e-17 2.9e-14 18 RP11-122G18.5
5 2 60466491 62087165 2 1 7.3e-08 1.8e-12 5.4e-06 58 AC010733.5
6 2 199443880 201021954 1 1 2.6e-07 2.3e-07 1.0e+00 100 SATB2
7 2 218382236 219878756 5 1 1.0e-08 2.0e-07 2.1e-01 94 AAMP
8 3 47911521 50932324 22 1 2.6e-14 2.3e-15 1.0e+00 100 FAM212A
9 5 131008194 132425049 1 1 1.6e-07 4.9e-06 2.8e-01 94 SLC22A5
10 6 116091635 117481404 1 1 2.0e-07 6.2e-07 1.6e-01 92 FAM26F
11 7 2032803 3581391 2 1 1.1e-08 1.2e-08 3.2e-01 97 AMZ1
12 7 5726022 7141565 1 1 2.0e-07 2.3e-05 8.2e-01 100 RAC1
13 7 106847492 108340749 3 1 9.9e-16 1.7e-15 9.2e-03 89 DLD
14 7 127878155 129284182 1 1 5.4e-08 2.9e-07 1.0e+00 100 IRF5
15 9 138558883 140071683 6 2 7.1e-15 5.8e-13 1.5e-01 96 CARD9 INPP5E
16 17 37101380 39048774 9 1 1.1e-10 9.2e-12 2.3e-02 89 STARD3
17 20 61576647 62912463 4 1 2.8e-11 3.4e-08 5.4e-01 99 RTEL1
18 22 49656585 51055900 1 1 1.6e-07 2.4e-08 1.0e+00 100 PIM3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 12.49 8 8 24.2 -0.93 6.6e-04 AC010733.5 CARD9 FAM212A INPP5E PARK7 RTEL1 SLC22A5 STARD3
Irritable Bowel Disease (IBD) 21.66 19 14 42.4 -0.94 4.1e-10 AAMP AC010733.5 AMZ1 CARD9 DLD FAM212A INPP5E IRF5 OTUD3 PARK7 PIM3 PLA2G5 RAC1 RP11-122G18.5 RP3-395M20.9 RTEL1 SATB2 SLC22A5 STARD3
Ulcerative Colitis (UC) 25.17 20 15 45.5 -0.99 4.1e-18 AAMP AC010733.5 AMZ1 CARD9 DLD FAM212A FAM26F INPP5E IRF5 OTUD3 PARK7 PIM3 PLA2G5 RAC1 RP11-122G18.5 RP3-395M20.9 RTEL1 SATB2 SLC22A5 STARD3
Verbal and Numeric Reasoning (VNR) 1.90 1 1 3.0 0.00 1.0e+00 FAM212A
Breast Cancer 1.53 3 0 0.0 0.00 1.0e+00 FAM212A PARK7 SLC22A5
Prostate Cancer 2.21 2 0 0.0 0.00 1.0e+00 FAM212A RTEL1
Age at First Birth 2.39 1 1 3.0 0.00 1.0e+00 FAM212A
Body Mass Index (BMI) (2010) 1.59 1 0 0.0 0.00 1.0e+00 RP3-395M20.9
Crohns Disease (2012) 7.74 5 3 9.1 -0.05 9.3e-01 AC010733.5 FAM212A RTEL1 SLC22A5 STARD3
HDL Cholesterol 2.20 2 2 6.1 0.00 1.0e+00 RAC1 STARD3
Lupus 5.81 1 1 3.0 0.00 1.0e+00 IRF5
Primary Biliary Cirrhosis 4.03 2 1 3.0 0.00 1.0e+00 IRF5 STARD3
Rheumatoid Arthritis 3.31 3 1 3.0 0.00 1.0e+00 IRF5 RP3-395M20.9 STARD3
Blood Eosinophil Count 4.41 4 3 9.1 -0.52 4.8e-01 AMZ1 IRF5 RP3-395M20.9 SLC22A5
Blood Platelet Count 1.95 8 5 15.2 -0.49 2.2e-01 AAMP AMZ1 IRF5 PARK7 RP11-122G18.5 RTEL1 SLC22A5 STARD3
Blood Red Count 0.44 2 0 0.0 0.00 1.0e+00 FAM212A RTEL1
Blood White Count 7.04 9 8 24.2 -0.19 6.3e-01 AAMP AC010733.5 AMZ1 CARD9 FAM212A INPP5E RTEL1 SLC22A5 STARD3
Heel T-Score 1.11 6 2 6.1 -0.43 3.9e-01 AAMP AMZ1 FAM212A IRF5 RAC1 SATB2
BMI 1.53 3 1 3.0 0.00 1.0e+00 FAM212A RP3-395M20.9 RTEL1
Height 3.73 9 8 24.2 0.46 2.1e-01 AAMP AMZ1 CARD9 FAM212A FAM26F INPP5E IRF5 PARK7 SLC22A5
Waist Hip Ratio (WHR) 0.87 2 1 3.0 0.00 1.0e+00 AAMP DLD
Systolic Blood Pressure 1.09 4 1 3.0 -0.06 9.4e-01 AAMP FAM212A IRF5 RAC1
Smoking Status 1.77 2 1 3.0 0.00 1.0e+00 AC010733.5 RTEL1
Allergy or Eczema 3.06 5 3 9.1 0.41 4.9e-01 AC010733.5 AMZ1 RTEL1 SLC22A5 STARD3
Cardiovascular Disease 1.45 1 0 0.0 0.00 1.0e+00 SLC22A5
Hypothyroidism (self reported) 1.42 2 0 0.0 0.00 1.0e+00 AC010733.5 IRF5
Respiratory disease 7.49 3 2 6.1 0.00 1.0e+00 RTEL1 SLC22A5 STARD3
Lung FEV1/FVC ratio 2.12 5 3 9.1 -0.61 2.7e-01 AC010733.5 AMZ1 FAM212A SLC22A5 STARD3
Lung FVC 2.46 8 5 15.2 -0.07 8.7e-01 AAMP CARD9 FAM212A PARK7 RTEL1 SATB2 SLC22A5 STARD3
Neuroticism 1.25 2 0 0.0 0.00 1.0e+00 FAM212A SATB2
Chronotype (morning person) 1.76 2 0 0.0 0.00 1.0e+00 AC010733.5 PARK7
Tanning 0.13 1 0 0.0 0.00 1.0e+00 PIM3
Hand grip strength (left) 1.55 2 0 0.0 0.00 1.0e+00 AMZ1 SLC22A5
Number of treatments/medications taken 2.19 1 1 3.0 0.00 1.0e+00 FAM212A
Average weekly spirits intake 1.97 1 0 0.0 0.00 1.0e+00 FAM212A
Hearing difficulty/problems: Yes 1.59 1 0 0.0 0.00 1.0e+00 SATB2
Relative age of first facial hair 1.41 1 0 0.0 0.00 1.0e+00 SATB2
Systolic blood pressure, automated reading 1.14 1 0 0.0 0.00 1.0e+00 FAM212A
Medication: Co-codamol 2.18 1 0 0.0 0.00 1.0e+00 FAM212A
Diabetes (father) 1.69 1 0 0.0 0.00 1.0e+00 PIM3
Impedance of leg (right) 0.62 1 0 0.0 0.00 1.0e+00 RP11-122G18.5
Leg fat-free mass (left) 2.51 4 2 6.1 -0.95 4.8e-02 AAMP AMZ1 FAM212A PARK7
Trunk fat percentage 1.96 4 2 6.1 -0.48 5.2e-01 AMZ1 FAM212A RP3-395M20.9 RTEL1
Hand grip strength (right) 1.58 2 0 0.0 0.00 1.0e+00 FAM212A SLC22A5
Current tobacco smoking 1.86 1 1 3.0 0.00 1.0e+00 RTEL1
Fed-up feelings 1.82 1 1 3.0 0.00 1.0e+00 FAM212A
Relative age voice broke 1.31 1 0 0.0 0.00 1.0e+00 SATB2
Taking other prescription medications 2.64 2 0 0.0 0.00 1.0e+00 FAM212A STARD3
Age when periods started (menarche) 3.11 3 1 3.0 0.00 1.0e+00 FAM212A IRF5 SATB2
High blood pressure 0.98 1 0 0.0 0.00 1.0e+00 SLC22A5
Hayfever, allergic rhinitis or eczema 3.42 4 3 9.1 -0.08 9.2e-01 AC010733.5 RTEL1 SLC22A5 STARD3
Medication: Levothyroxine sodium 1.59 1 0 0.0 0.00 1.0e+00 AC010733.5
Sitting height 3.49 6 6 18.2 -0.62 1.9e-01 AAMP AMZ1 CARD9 FAM26F INPP5E PARK7
Body mass index (BMI) 1.61 3 1 3.0 0.00 1.0e+00 FAM212A RP3-395M20.9 RTEL1
Impedance of leg (left) 0.57 1 0 0.0 0.00 1.0e+00 FAM212A
Leg predicted mass (left) 2.48 4 2 6.1 -0.95 4.6e-02 AAMP AMZ1 FAM212A PARK7
Trunk fat mass 2.54 4 2 6.1 -0.61 3.9e-01 AMZ1 FAM212A RP3-395M20.9 RTEL1
Waist circumference 1.82 3 2 6.1 0.00 1.0e+00 AMZ1 FAM212A RTEL1
Nervous feelings 1.22 1 0 0.0 0.00 1.0e+00 SATB2
Frequency of tenseness / restlessness in last 2 weeks 1.08 1 0 0.0 0.00 1.0e+00 FAM212A
Forced vital capacity (FVC) 2.07 5 3 9.1 -0.46 4.4e-01 AAMP AMZ1 FAM212A RTEL1 SATB2
Qualifications: None of the above 1.93 1 1 3.0 0.00 1.0e+00 FAM212A
Mouth/teeth dental problems 1.59 1 0 0.0 0.00 1.0e+00 IRF5
Allergy 5.17 5 4 12.1 0.20 7.4e-01 AC010733.5 AMZ1 RTEL1 SLC22A5 STARD3
Pain all over the body in last month 2.04 1 0 0.0 0.00 1.0e+00 FAM212A
Fluid intelligence score 1.90 1 1 3.0 0.00 1.0e+00 FAM212A
Neuroticism score 1.04 1 0 0.0 0.00 1.0e+00 FAM212A
Weight 2.73 4 2 6.1 -0.68 3.2e-01 AMZ1 FAM212A PARK7 RTEL1
Impedance of arm (right) 1.39 4 1 3.0 -1.00 2.1e-03 AMZ1 FAM212A RAC1 SATB2
Arm fat percentage (right) 1.45 3 1 3.0 0.00 1.0e+00 AMZ1 FAM212A RTEL1
Trunk fat-free mass 2.52 6 3 9.1 -0.56 2.5e-01 AAMP AMZ1 CARD9 FAM212A INPP5E PARK7
Hip circumference 2.36 4 3 9.1 -0.65 3.5e-01 AMZ1 FAM212A PARK7 RTEL1
Alcohol intake versus 10 years previously 1.59 1 1 3.0 0.00 1.0e+00 FAM212A
Father's age at death 1.81 1 0 0.0 0.00 1.0e+00 FAM212A
Worrier / anxious feelings 1.21 1 0 0.0 0.00 1.0e+00 SATB2
Forced expiratory volume in 1-second (FEV1) 1.71 4 2 6.1 -0.35 6.5e-01 AAMP FAM212A RTEL1 SATB2
Qualifications: A levels/AS levels or equivalent 2.79 1 1 3.0 0.00 1.0e+00 FAM212A
Mouth/teeth dental problems: Dentures 1.66 2 0 0.0 0.00 1.0e+00 FAM212A STARD3
Asthma 7.03 3 2 6.1 0.00 1.0e+00 RTEL1 SLC22A5 STARD3
Forced expiratory volume in 1-second (FEV1), Best measure 1.66 3 1 3.0 0.00 1.0e+00 AAMP FAM212A SATB2
Impedance of arm (left) 1.59 4 2 6.1 -1.00 5.1e-04 AMZ1 FAM212A RAC1 SATB2
Arm fat mass (right) 1.93 3 2 6.1 0.00 1.0e+00 AMZ1 FAM212A RTEL1
Trunk predicted mass 2.50 6 3 9.1 -0.56 2.5e-01 AAMP AMZ1 CARD9 FAM212A INPP5E PARK7
Standing height 3.68 8 6 18.2 -0.46 2.5e-01 AAMP AMZ1 CARD9 FAM26F INPP5E IRF5 PARK7 SLC22A5
Birth weight of first child 1.34 1 0 0.0 0.00 1.0e+00 RAC1
Qualifications: O levels/GCSEs or equivalent 1.69 1 0 0.0 0.00 1.0e+00 FAM212A
Medication: Paracetamol 1.12 1 0 0.0 0.00 1.0e+00 FAM212A
Hypothyroidism/myxoedema (self-reported) 1.36 1 0 0.0 0.00 1.0e+00 AC010733.5
Medication: Ventolin 100micrograms inhaler 3.85 1 1 3.0 0.00 1.0e+00 STARD3
Birth weight 2.18 2 1 3.0 0.00 1.0e+00 AMZ1 PIM3
Forced vital capacity (FVC), Best measure 1.94 5 2 6.1 -0.51 3.8e-01 AAMP AMZ1 FAM212A RTEL1 SATB2
Body fat percentage 1.89 4 2 6.1 -0.28 7.2e-01 AMZ1 FAM212A RP3-395M20.9 RTEL1
Leg fat percentage (right) 2.02 3 2 6.1 0.00 1.0e+00 FAM212A RP3-395M20.9 RTEL1
Arm fat-free mass (right) 2.42 5 3 9.1 -0.39 5.2e-01 AAMP AMZ1 CARD9 FAM212A PARK7
Wheeze or whistling in the chest in last year 3.74 3 3 9.1 0.00 1.0e+00 FAM212A RTEL1 STARD3
Age at first live birth 1.76 1 1 3.0 0.00 1.0e+00 FAM212A
Health satisfaction 1.29 1 0 0.0 0.00 1.0e+00 FAM212A
Qualifications: College or University degree 3.11 3 1 3.0 0.00 1.0e+00 AC010733.5 FAM212A RTEL1
Emphysema/chronic bronchitis 1.81 1 0 0.0 0.00 1.0e+00 STARD3
Medication: Seretide 50 evohaler 2.30 1 0 0.0 0.00 1.0e+00 FAM212A
Whole body fat mass 2.42 4 2 6.1 -0.48 5.2e-01 AMZ1 FAM212A RP3-395M20.9 RTEL1
Leg fat mass (right) 2.23 4 2 6.1 -0.26 7.4e-01 AMZ1 FAM212A RP3-395M20.9 RTEL1
Arm predicted mass (right) 2.52 5 3 9.1 -0.38 5.2e-01 AAMP AMZ1 CARD9 FAM212A PARK7
Pulse rate, automated reading 1.08 1 0 0.0 0.00 1.0e+00 FAM212A
Alcohol intake frequency. 1.08 1 0 0.0 0.00 1.0e+00 FAM212A
Comparative height size at age 10 2.98 5 4 12.1 -0.71 1.8e-01 AAMP AMZ1 CARD9 INPP5E SLC22A5
Suffer from 'nerves' 1.71 1 1 3.0 0.00 1.0e+00 SATB2
Overall health rating 2.07 2 1 3.0 0.00 1.0e+00 AMZ1 FAM212A
Chest pain or discomfort 1.13 1 0 0.0 0.00 1.0e+00 STARD3
Age at last live birth 1.90 1 1 3.0 0.00 1.0e+00 FAM212A
Leg pain on walking 1.28 1 0 0.0 0.00 1.0e+00 FAM212A
Hypertension (Self-reported) 0.86 1 0 0.0 0.00 1.0e+00 SLC22A5
Forced expiratory volume in 1-second (FEV1), predicted 2.50 2 1 3.0 0.00 1.0e+00 AMZ1 CARD9
Whole body fat-free mass 2.55 6 3 9.1 -0.55 2.6e-01 AAMP AMZ1 CARD9 FAM212A INPP5E PARK7
Leg fat-free mass (right) 2.44 5 1 3.0 -0.46 4.4e-01 AAMP AMZ1 CARD9 FAM212A PARK7
Arm fat percentage (left) 1.54 4 2 6.1 -0.19 8.1e-01 AMZ1 FAM212A RP3-395M20.9 RTEL1
Mood swings 1.16 1 1 3.0 0.00 1.0e+00 FAM212A
Loneliness, isolation 1.23 1 0 0.0 0.00 1.0e+00 FAM212A
Qualifications: nursing, teaching 1.62 1 0 0.0 0.00 1.0e+00 FAM212A
Mouth/teeth dental problems: Mouth ulcers 2.31 2 2 6.1 0.00 1.0e+00 IRF5 STARD3
Asthma (self-reported) 7.04 2 2 6.1 0.00 1.0e+00 SLC22A5 STARD3
Smoking status: Current 1.70 1 0 0.0 0.00 1.0e+00 RTEL1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.62 2 0 0.0 0.00 1.0e+00 AMZ1 STARD3
Whole body water mass 2.52 6 3 9.1 -0.55 2.6e-01 AAMP AMZ1 CARD9 FAM212A INPP5E PARK7
Leg predicted mass (right) 2.45 5 1 3.0 -0.45 4.4e-01 AAMP AMZ1 CARD9 FAM212A PARK7
Arm fat mass (left) 1.94 3 2 6.1 0.00 1.0e+00 AMZ1 FAM212A RTEL1
Miserableness 1.56 1 1 3.0 0.00 1.0e+00 FAM212A
Guilty feelings 1.10 1 0 0.0 0.00 1.0e+00 FAM212A
Financial situation satisfaction 1.10 1 0 0.0 0.00 1.0e+00 FAM212A
Medication: Paracetamol 1.27 1 0 0.0 0.00 1.0e+00 FAM212A
Basal metabolic rate 2.64 6 3 9.1 -0.53 2.8e-01 AAMP AMZ1 CARD9 FAM212A INPP5E PARK7
Leg fat percentage (left) 2.04 3 2 6.1 0.00 1.0e+00 FAM212A RP3-395M20.9 RTEL1
Arm fat-free mass (left) 2.46 6 3 9.1 -0.49 3.3e-01 AAMP AMZ1 CARD9 FAM212A INPP5E PARK7
Number of operations (self-reported) 2.67 2 1 3.0 0.00 1.0e+00 AMZ1 PARK7
Average weekly beer plus cider intake 1.47 1 0 0.0 0.00 1.0e+00 FAM212A
Diastolic blood pressure, automated reading 1.70 2 1 3.0 0.00 1.0e+00 FAM212A RTEL1
Unable to work because of sickness or disability 1.02 1 0 0.0 0.00 1.0e+00 DLD
Vascular/heart problems diagnosed by doctor 1.13 1 0 0.0 0.00 1.0e+00 SLC22A5
Medication: Omeprazole (e.g. Zanprol) 1.70 1 0 0.0 0.00 1.0e+00 SATB2
Pain experienced in last month 1.65 1 0 0.0 0.00 1.0e+00 FAM212A
Impedance of whole body 0.94 2 1 3.0 0.00 1.0e+00 FAM212A SATB2
Leg fat mass (left) 2.27 4 2 6.1 -0.25 7.5e-01 AMZ1 FAM212A RP3-395M20.9 RTEL1
Arm predicted mass (left) 2.55 6 4 12.1 -0.48 3.4e-01 AAMP AMZ1 CARD9 FAM212A INPP5E PARK7

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.0598 1.51
GTEx Adipose Visceral Omentum 6 0.3043 1.54
GTEx Adrenal Gland 1 0.0710 1.59
GTEx Artery Aorta 2 0.0699 1.45
GTEx Artery Coronary 1 0.0877 1.56
GTEx Artery Tibial 5 0.1391 1.53
GTEx Brain Caudate basal ganglia 1 0.1127 1.46
GTEx Brain Cerebellar Hemisphere 4 0.2774 1.60
GTEx Brain Cerebellum 6 0.3128 1.54
GTEx Brain Cortex 2 0.1998 1.64
GTEx Brain Frontal Cortex BA9 2 0.2232 1.54
GTEx Brain Hippocampus 0 0.0000 1.40
GTEx Brain Hypothalamus 2 0.3509 1.58
GTEx Brain Nucleus accumbens basal ganglia 2 0.2387 1.47
GTEx Brain Putamen basal ganglia 0 0.0000 1.36
GTEx Breast Mammary Tissue 3 0.1581 1.53
GTEx Breast Mammary Tissue (Male) 1 0.0880 1.45
GTEx Breast Mammary Tissue (Female) 2 0.1289 1.51
GTEx Cells EBV-transformed lymphocytes 6 0.4367 1.66
GTEx Cells Transformed fibroblasts 6 0.1483 1.50
GTEx Colon Sigmoid 1 0.0706 1.61
GTEx Colon Transverse 4 0.2013 1.56
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.53
GTEx Esophagus Mucosa 5 0.1559 1.57
GTEx Esophagus Muscularis 9 0.2896 1.55
GTEx Heart Atrial Appendage 3 0.1958 1.55
GTEx Heart Left Ventricle 0 0.0000 1.50
GTEx Liver 0 0.0000 1.49
GTEx Lung 4 0.1450 1.60
GTEx Muscle Skeletal 2 0.0716 1.53
GTEx Nerve Tibial 6 0.1439 1.49
GTEx Ovary 1 0.1135 1.62
GTEx Pancreas 1 0.0633 1.54
GTEx Pituitary 0 0.0000 1.61
GTEx Prostate 1 0.1242 1.56
GTEx Skin Not Sun Exposed Suprapubic 3 0.1259 1.55
GTEx Skin Sun Exposed Lower leg 5 0.1428 1.57
GTEx Small Intestine Terminal Ileum 0 0.0000 1.43
GTEx Spleen 5 0.3647 1.71
GTEx Stomach 1 0.0715 1.54
GTEx Testis 6 0.1958 1.54
GTEx Thyroid 4 0.1041 1.53
GTEx Uterus 2 0.3656 1.56
GTEx Vagina 1 0.1645 1.60
GTEx Whole Blood 6 0.3130 1.79
METSIM Adipose 6 0.1339 1.50
NTR Blood 9 0.3785 1.61
ROSMAP Brain Pre-frontal Cortex 7 0.1640 1.59
YFS Blood 10 0.2208 1.57
CommonMind Brain Pre-frontal Cortex 6 0.1141 1.49
TCGA Breast Tumor 1 0.1326 1.42
TCGA Breast Normal 1 0.0244 1.35
TCGA Ovarian Tumor 0 0.0000 1.39
TCGA Prostate Tumor 3 0.0893 1.50