TWAS hub - PIM3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0428	0.0126	8.2e-06	0.040	0.012	0.037	0.009	0.019	8.9e-13	8.4e-05	5.5e-12	0.00051	6.1e-07
2	TCGA	Prostate Adenocarcinoma	0.0784	0.0397	6.5e-03	0.012	0.017	0.031	NA	0.032	1.7e-02	5.8e-03	3.2e-04	NA	2.5e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Ulcerative Colitis (UC)	12.6	23.6	35.1	5.9	-3.5
Medication: Ramipril	10.0	12.8	13.4	3.5	-3.7
Ulcerative Colitis	9.5	13.7	27.5	5.2	0.0
Medication: Co-codamol	8.8	10.2	12.5	-3.5	2.8
Diabetes (father)	8.1	10.1	15.0	3.9	-2.3
Diabetes (self-reported)	7.8	12.0	12.5	3.4	-3.5
Age started oral contraceptive pill	7.3	9.2	9.3	3.0	-3.1
Birth weight	7.0	15.2	21.8	-4.7	2.9
Type 2 Diabetes (T2D) (2018)	6.7	12.5	14.5	3.2	-3.8
Pain all over the body in last month	5.9	6.3	7.4	2.3	-2.7
Diabetes diagnosed by doctor	5.2	8.6	8.9	3.0	-2.9
Irritable Bowel Disease (IBD)	4.8	11.3	15.3	3.9	-2.7
Had major operations	4.4	5.1	8.3	-2.9	1.4
Number of operations (self-reported)	4.3	6.3	11.9	-3.5	0.9
Ever had prostate specific antigen (PSA) test	3.9	4.5	5.9	-1.8	2.4
Sensitivity / hurt feelings	3.6	6.1	7.9	-2.8	2.1
Lung cancer (father)	3.3	3.9	4.7	-2.2	1.7
Depression (self-reported)	3.2	3.8	5.3	1.5	-2.3
Stomach or abdominal pain in last month	3.1	3.9	7.3	2.7	-0.7
Exposure to tobacco smoke outside home	3.0	4.0	5.6	1.5	-2.4
Medication: Blood pressure	2.8	5.3	9.6	1.0	-3.1
Medication: Atorvastatin	2.8	3.5	5.2	1.3	-2.3
Back pain experienced in last month	2.7	3.9	5.0	-2.2	1.7
Breast cancer (self-reported)	2.6	3.1	5.9	-2.4	0.4
High blood pressure (mother)	2.4	3.4	4.6	1.5	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	2.4	5.6	6.2	2.5	-2.3
Prospective memory result	2.4	3.0	3.7	-1.9	1.5
Family relationship satisfaction	2.4	3.0	3.5	1.9	-1.6
Alzheimer’s Disease (in mother)	2.3	2.7	4.6	-2.1	0.9
Alzheimer’s Disease (including proxy)	2.3	3.3	5.7	-2.4	1.0
Medication: Metformin	2.3	3.3	3.3	1.8	-1.8
Asthma	2.0	4.0	7.2	2.7	-0.9
Leg pain on walking	2.0	2.5	4.6	-2.2	0.7
Medication: Gliclazide	2.0	2.3	2.5	1.6	-1.4
Prostate Cancer	1.9	2.7	5.1	-2.2	0.6
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.4	5.6	2.4	-1.8
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	3.9	0.5	-2.0
Supplements: Glucosamine	1.8	2.4	3.1	-1.3	1.8
Noisy workplace	1.8	2.3	2.6	-1.4	1.6
Hair/balding pattern: Pattern 4	1.8	4.4	5.8	1.7	-2.4
Peak expiratory flow (PEF)	1.8	4.3	7.2	1.2	-2.7
Bipolar Disorder or Schizophrenia	1.7	4.2	8.4	2.9	0.0
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	2.9	1.7	-1.6
Heart disease (siblings)	1.7	2.1	2.3	1.5	-1.4
Blood White Count	1.6	12.0	13.2	-3.3	3.6
Chronotype (morning person)	1.6	3.8	4.8	-2.2	1.7
Fed-up feelings	1.6	2.8	3.3	1.8	-1.6
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	4.9	-2.2	0.5
Medication for cholesterol	1.6	2.5	4.8	0.4	2.2
Commuting to job workplace: Cycle	1.6	1.9	2.9	-1.7	1.0
Schizophrenia (2018)	1.5	3.2	6.3	2.5	0.0
Schizophrenia (2014)	1.5	3.3	6.6	2.6	0.0
Average weekly spirits intake	1.5	1.9	2.8	-1.7	-1.0
Health satisfaction	1.5	2.0	3.9	-0.3	-2.0
Handedness (chirality/laterality): Left-handed	1.5	1.8	3.0	1.7	-0.8
Cholesterol lowering medication	1.5	2.2	4.0	0.6	-2.0
High blood pressure	1.4	3.8	5.6	1.4	-2.4
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	3.3	-1.8	0.2
Hearing difficulty/problems with background noise	1.4	2.3	2.9	1.7	-1.3
Medication: Cholesterol lowering	1.4	2.2	3.5	0.9	-1.9
Gout (self-reported)	1.4	1.9	3.3	1.8	-0.6
Asthma (self-reported)	1.4	2.8	5.3	2.3	-0.6
Hypothyroidism (self reported)	1.3	2.9	4.0	-2.0	1.3
Hair/balding pattern: Pattern 2	1.3	1.6	1.7	-1.2	1.3
Comparative body size at age 10	1.3	3.6	5.9	2.4	-1.1
Medication: Seretide 50 evohaler	1.3	1.5	3.0	1.7	-0.3
Hypertension (Self-reported)	1.3	3.6	5.5	1.3	-2.3
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.7	1.6	0.0
Lung FEV1/FVC ratio	1.2	6.3	6.9	2.4	-2.6
Mouth/teeth dental problems	1.2	1.8	3.0	1.7	-0.8
Glaucoma (self-reported)	1.2	1.4	2.8	-1.7	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	1.5	1.2	-1.2
Commuting to job workplace: Car/motor vehicle	1.2	1.3	2.5	-0.4	-1.6
Vascular/heart problems diagnosed by doctor	1.2	3.2	5.2	-1.1	2.3
Alcohol drinker status: Previous	1.2	1.4	2.4	1.6	-0.6
Tanning	1.1	13.6	21.0	-4.6	2.5
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	1.6	1.3	-0.9
Relative age voice broke	1.1	1.7	3.2	1.8	-0.4
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.1	1.5	-0.7
Impedance of arm (right)	1.1	4.9	6.0	2.5	-2.0
Happiness	1.1	1.3	2.6	-0.2	-1.6
Townsend deprivation index at recruitment	1.0	1.4	1.9	1.4	-1.0
Medication: Simvastatin	1.0	1.4	2.5	0.6	-1.6
Number of full brothers	1.0	1.3	1.4	1.2	-1.1
Suffer from ‘nerves’	1.0	1.5	1.7	1.1	-1.3
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.2	1.5	-0.5
Supplements: Vitamin C	1.0	1.2	1.8	-1.4	0.7
Eye problems/disorders: Cataract	1.0	1.2	1.5	1.2	-0.9
Supplements: Fish oil (including cod liver oil)	1.0	1.4	2.7	0.1	-1.7
Unable to work because of sickness or disability	1.0	1.3	2.4	0.4	-1.6
Alzheimer’s Disease (in father)	0.9	0.9	1.4	-1.2	0.7
Cardiovascular Disease	0.9	3.1	4.2	1.4	-2.0
Medication: Atenolol	0.9	1.1	2.1	0.1	-1.5
Impedance of arm (left)	0.9	4.3	5.8	2.4	-1.7
Birth weight of first child	0.9	1.6	3.2	0.1	1.8
Eye problems/disorders: None of the above	0.9	1.1	2.1	-0.1	1.5
Ever taken oral contraceptive pill	0.9	1.0	1.9	0.2	1.4
Fasting Glucose	0.8	0.9	1.9	1.4	0.0
Hearing difficulty/problems: Yes	0.8	1.2	2.5	1.6	0.1
Ever had hysterectomy (womb removed)	0.8	0.9	1.7	1.3	-0.1
Fluid intelligence score	0.8	1.6	2.1	-1.0	1.5
Arm fat percentage (right)	0.8	3.0	6.1	0.0	-2.5
Number of live births	0.8	1.2	1.9	-1.4	0.7
Medication: Lansoprazole	0.8	1.0	1.7	0.5	-1.3
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	1.9	-0.9	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	1.8	-1.3	0.2
Illnesses of father: Heart disease	0.8	1.1	1.5	-1.2	0.9
Qualifications: nursing, teaching	0.8	1.2	2.2	1.5	0.4
Wears glasses or contact lenses	0.8	0.9	1.9	1.4	0.0
Hearing aid user	0.8	0.9	1.4	-0.6	1.2
Financial situation satisfaction	0.8	1.0	1.3	0.9	-1.1
Medication: Lisinopril	0.8	1.1	1.7	0.7	-1.3
Bipolar Disorder (2018)	0.7	1.1	2.3	1.5	0.0
Mean Putamen Volume	0.7	0.8	1.6	1.3	0.0
Respiratory disease	0.7	1.6	3.2	1.8	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.8	0.1	-1.3
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.2	-0.5	1.1
Financial difficulties in last 2 years	0.7	1.0	1.8	-1.3	0.4
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	2.6	1.6	-1.6
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	1.1	-1.0	0.9
Age at first live birth	0.7	1.2	2.2	1.5	-0.5
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.5	1.2	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.7	-0.3	1.3
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.3	-0.7	1.5
Primary Biliary Cirrhosis	0.6	0.8	1.7	-1.3	0.0
Heel T-Score	0.6	4.4	4.8	2.2	-2.0
Impedance of leg (right)	0.6	2.8	5.3	2.3	-0.6
Forced vital capacity (FVC)	0.6	2.1	3.0	1.7	-1.1
Qualifications: None of the above	0.6	1.3	1.6	-1.3	1.0
Hip circumference	0.6	2.5	4.8	-0.5	-2.2
Alcohol intake versus 10 years previously	0.6	0.9	1.1	0.9	-1.1
Exposure to tobacco smoke at home	0.6	0.7	0.7	0.8	-0.9
Blood clot in the leg (DVT)	0.6	0.7	1.3	-0.3	-1.2
Wheeze or whistling in the chest in last year	0.6	1.1	2.1	0.3	1.4
Number of children fathered	0.6	0.7	0.8	-0.9	0.8
Emphysema/chronic bronchitis	0.6	0.7	1.2	-1.1	0.5
Neck or shoulder pain in last month	0.6	0.9	1.5	1.2	-0.5
Angina (self-reported)	0.6	0.8	1.7	-0.1	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	1.8	-1.3	1.0
Arm fat percentage (left)	0.6	2.3	4.6	-0.1	-2.2
Number of self-reported non-cancer illnesses	0.6	1.0	1.7	1.3	-0.6
Average weekly champagne plus white wine intake	0.6	0.8	1.4	0.5	1.2
Commuting to job workplace: Public transport	0.6	0.8	1.4	0.3	1.2
Illnesses of father: High blood pressure	0.6	0.7	0.8	0.8	-0.9
Risk taking	0.6	0.9	1.2	-0.8	1.1
Breast Cancer	0.5	1.2	1.7	1.3	0.9
Height	0.5	8.8	9.1	2.9	-3.0
Trunk fat percentage	0.5	2.1	4.1	-0.2	-2.0
Hayfever, allergic rhinitis or eczema	0.5	1.2	2.0	0.6	-1.4
Alcohol usually taken with meals	0.5	0.7	0.9	-0.9	-0.8
Heart attack	0.5	0.6	0.8	-0.9	0.7
Allergy	0.5	1.2	1.7	-0.8	1.3
Hair/balding pattern: Pattern 3	0.5	0.7	1.3	1.1	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	0.6	-0.7	0.8
Illnesses of mother	0.5	0.6	1.0	0.5	1.0
Arm fat mass (right)	0.5	2.2	4.1	-0.5	-2.0
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	1.9	-1.4	0.4
Medication: Ventolin 100micrograms inhaler	0.5	0.6	0.9	1.0	0.6
Body fat percentage	0.5	1.9	3.8	-0.1	-1.9
Worry too long after embarrassment	0.5	0.9	1.5	-0.6	1.2
Heart disease (mother)	0.5	0.6	1.1	-1.0	-0.0
Medication: Aspirin	0.5	0.6	1.1	0.3	-1.1
Friendships satisfaction	0.5	0.6	1.1	-0.1	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	1.0	-0.3	1.0
Arm fat mass (left)	0.5	2.0	3.6	-0.6	-1.9
Mother’s age at death	0.5	0.7	1.4	0.1	-1.2
Eye problems/disorders: Glaucoma	0.5	0.6	1.1	-1.1	-0.4
Pain type(s) experienced in last month: Hip pain	0.5	0.6	0.7	-0.7	0.9
Impedance of whole body	0.5	2.5	4.3	2.1	-0.8
Depressed Affect (Nagel 2018)	0.4	0.8	1.5	1.2	0.0
Systolic Blood Pressure	0.4	2.2	2.5	1.6	-1.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.6	0.6	-0.8
Angina	0.4	0.6	1.1	0.0	-1.1
Taking other prescription medications	0.4	0.7	1.4	1.2	-0.1
Age when periods started (menarche)	0.4	0.9	1.6	-1.3	-0.4
Qualifications: CSEs or equivalent	0.4	0.6	0.6	0.7	-0.8
Body mass index (BMI)	0.4	1.5	1.6	-1.2	-1.2
Trunk fat mass	0.4	1.8	3.4	-0.4	-1.9
Waist circumference	0.4	1.6	3.0	0.4	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	0.8	0.6	-0.9
Time employed in main current job	0.4	0.5	0.6	-0.7	-0.6
Worrier / anxious feelings	0.4	0.7	1.4	1.2	0.3
Pulse wave Arterial Stiffness index	0.4	0.5	0.5	0.7	-0.7
Loud music exposure frequency	0.4	0.4	0.8	-0.9	0.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.2	1.1	-0.1
Medication: Ibuprofen	0.4	0.4	0.8	-0.3	0.9
Whole body fat mass	0.4	1.5	2.9	-0.4	-1.7
Leg fat mass (right)	0.4	1.5	2.3	-0.8	-1.5
Pulse rate, automated reading	0.4	1.2	1.9	-1.4	-0.7
Alcohol intake frequency.	0.4	0.8	1.5	0.4	-1.2
Age at last live birth	0.4	0.6	0.6	0.7	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.9	-0.1	0.9
Ever had bowel cancer screening	0.4	0.4	0.6	0.8	0.5
Mineral and other dietary supplements	0.4	0.6	0.6	0.8	0.7
Guilty feelings	0.4	0.6	1.1	0.2	1.1
Coronary Artery Disease (CAD)	0.3	0.4	0.7	0.8	0.0
Neuroticism (2016)	0.3	0.5	1.0	1.0	-0.0
Waist Hip Ratio (WHR)	0.3	1.5	2.4	1.5	0.8
Neuroticism	0.3	0.7	0.8	0.9	-0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.5	-0.4	-0.7
Medication for hormone replacement therapy	0.3	0.3	0.6	-0.8	-0.2
Severe depression (siblings)	0.3	0.3	0.6	0.1	0.8
Leg fat-free mass (left)	0.3	1.4	2.1	-1.5	-0.8
Maternal smoking around birth	0.3	0.5	0.8	-0.3	-0.9
Serious illness, injury or assault to yourself	0.3	0.4	0.6	0.4	-0.8
Impedance of leg (left)	0.3	1.5	3.1	1.8	0.1
Leg predicted mass (left)	0.3	1.5	2.4	-1.6	-0.7
Nervous feelings	0.3	0.6	1.0	0.5	-1.0
Had other major operations	0.3	0.3	0.6	-0.3	-0.8
Weight	0.3	1.5	2.3	-0.9	-1.5
Pulse rate	0.3	0.5	0.9	-0.2	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.6	-0.3	0.7
Tense / ‘highly strung’	0.3	0.4	0.6	-0.8	0.5
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.6	-0.8	0.1
Headache pain in last month	0.3	0.5	0.8	0.5	-0.9
Leg fat percentage (right)	0.3	1.2	2.4	-0.2	-1.6
Medication: Omeprazole	0.3	0.4	0.7	-0.3	0.9
Leg fat-free mass (right)	0.3	1.7	3.2	-1.8	-0.3
Average weekly red wine intake	0.3	0.5	0.7	-0.8	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	-0.7	-0.4
Commuting to job workplace: Walk	0.3	0.4	0.7	0.2	0.8
Osteoporosis (self-reported)	0.3	0.4	0.6	0.8	-0.4
Smoking status: Current	0.3	0.5	0.7	-0.6	0.8
Leg predicted mass (right)	0.3	1.6	3.2	-1.8	-0.3
Supplements: Calcium	0.3	0.3	0.6	0.8	-0.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.4	-0.6	0.6
Leg fat mass (left)	0.3	1.3	1.8	-0.9	-1.3
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.0	-1.0	0.0
Crohns Disease (2017)	0.2	0.4	0.8	0.2	-0.9
Reaction Time	0.2	0.4	0.5	0.6	-0.7
Lupus	0.2	0.3	0.3	-0.6	0.5
Blood Platelet Count	0.2	2.5	4.7	2.2	-0.6
BMI	0.2	1.2	1.7	-0.8	-1.3
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.3	0.5	-0.5
Relative age of first facial hair	0.2	0.4	0.5	0.7	-0.6
Vitamin and mineral supplements	0.2	0.3	0.6	0.8	-0.1
Current tobacco smoking	0.2	0.3	0.5	-0.2	0.7
Average weekly fortified wine intake	0.2	0.2	0.4	-0.6	-0.2
Medication: Levothyroxine sodium	0.2	0.3	0.6	-0.8	0.0
Sitting height	0.2	1.5	2.0	-1.0	-1.4
Past tobacco smoking	0.2	0.3	0.4	0.6	-0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.3	0.5	0.5
Illnesses of siblings	0.2	0.2	0.4	-0.7	-0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.7	0.8	0.3
Length of working week for main job	0.2	0.3	0.5	-0.7	-0.2
Pulse wave reflection index	0.2	0.3	0.4	0.6	-0.4
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.3	0.3	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.3	-0.4	-0.5
Pulse wave peak to peak time	0.2	0.3	0.3	-0.5	0.5
Medication: Blood pressure	0.2	0.4	0.9	0.1	-0.9
Number of full sisters	0.2	0.2	0.4	-0.1	-0.6
Overall health rating	0.2	0.5	0.8	0.5	-0.9
Illnesses of siblings: Diabetes	0.2	0.2	0.4	0.6	-0.0
Whole body fat-free mass	0.2	0.9	1.8	-1.4	-0.3
Loneliness, isolation	0.2	0.2	0.4	0.2	-0.6
Long-standing illness, disability or infirmity	0.2	0.3	0.5	0.3	-0.7
Medication: Aspirin	0.2	0.3	0.5	-0.2	-0.7
Whole body water mass	0.2	0.9	1.6	-1.3	-0.4
High cholesterol (Self-reported)	0.2	0.4	0.5	0.5	-0.7
Medication: Paracetamol	0.2	0.3	0.5	-0.7	-0.3
Alcohol drinker status: Never	0.2	0.2	0.4	-0.6	-0.1
Basal metabolic rate	0.2	1.0	1.5	-1.2	-0.8
Leg fat percentage (left)	0.2	0.7	1.2	-0.5	-1.1
Fractured/broken bones in last 5 years	0.2	0.2	0.4	-0.6	0.2
Diastolic blood pressure, automated reading	0.2	0.7	1.3	-1.2	0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.6	-0.0	-0.7
Arm predicted mass (left)	0.2	1.1	2.0	-1.4	-0.5
Schizophrenia vs Biploar Disorder	0.1	0.2	0.4	0.6	0.0
Worry (Nagel 2018)	0.1	0.2	0.4	0.6	0.0
Ovarian Cancer	0.1	0.2	0.3	0.3	-0.6
Age at First Birth	0.1	0.1	0.3	0.5	0.0
LDL Cholesterol	0.1	0.1	0.2	0.5	0.0
Triglycerides	0.1	0.2	0.4	0.6	0.0
Blood Eosinophil Count	0.1	0.7	1.4	0.1	1.2
Smoking Status	0.1	0.2	0.2	0.5	-0.4
Allergy or Eczema	0.1	0.3	0.6	0.1	-0.8
Number of treatments/medications taken	0.1	0.2	0.4	-0.0	-0.6
Supplements: Zinc	0.1	0.1	0.3	-0.1	0.5
Pack years adult smoking proportion	0.1	0.1	0.2	0.4	-0.2
Hand grip strength (right)	0.1	0.3	0.5	-0.7	0.1
Multivitamins +/- minerals	0.1	0.2	0.3	-0.5	-0.3
Number of incorrect matches in round	0.1	0.2	0.5	-0.7	-0.2
Trunk fat-free mass	0.1	0.4	0.8	-0.9	-0.3
Father’s age at death	0.1	0.2	0.2	0.5	-0.4
Falls in the last year	0.1	0.2	0.4	-0.6	-0.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.2	0.4	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.7	0.9	-0.2
Trunk predicted mass	0.1	0.4	0.8	-0.9	-0.3
Standing height	0.1	0.7	0.8	0.8	-0.9
Breastfed as a baby	0.1	0.1	0.2	-0.3	-0.4
Medication: Paracetamol	0.1	0.2	0.4	-0.6	-0.3
Medication: Amlodipine	0.1	0.1	0.2	0.1	0.4
Forced vital capacity (FVC), Best measure	0.1	0.5	0.6	0.8	0.6
Arm fat-free mass (right)	0.1	0.7	1.3	-1.2	0.1
Shortness of breath walking on level ground	0.1	0.1	0.1	-0.4	-0.1
Qualifications: College or University degree	0.1	0.3	0.5	0.7	0.0
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	0.6	0.1
Migraine (self-reported)	0.1	0.1	0.3	-0.1	0.5
Arm predicted mass (right)	0.1	0.6	1.3	-1.1	-0.0
Chest pain or discomfort	0.1	0.1	0.2	0.4	-0.2
Mood swings	0.1	0.2	0.3	0.6	-0.4
Miserableness	0.1	0.2	0.3	0.5	-0.4
Medication: Bendroflumethiazide	0.1	0.2	0.3	-0.6	-0.3
Ever smoked	0.1	0.2	0.4	-0.6	-0.0
Arm fat-free mass (left)	0.1	0.5	0.9	-0.9	-0.4
Average weekly beer plus cider intake	0.1	0.1	0.1	0.4	0.2
Irritability	0.1	0.1	0.2	0.4	-0.2
Ever depressed for a whole week	0.1	0.1	0.2	0.4	0.2
Myopia	0.1	0.2	0.3	0.6	0.0
Pain experienced in last month	0.1	0.1	0.2	0.5	0.0
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	-0.0	-0.4
Pack years of smoking	0.1	0.1	0.1	0.4	-0.3
Depression (Nagel 2018)	0.0	0.0	0.0	0.0	0.0
Neuroticism (Nagel 2018)	0.0	0.0	0.0	-0.2	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.2	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.1	0.3	0.0
HbA1C	0.0	0.0	0.0	0.1	0.0
HDL Cholesterol	0.0	0.0	0.0	-0.1	0.0
Rheumatoid Arthritis	0.0	0.1	0.1	0.3	0.0
Blood Red Count	0.0	0.3	0.6	-0.2	-0.7
Lung FVC	0.0	0.1	0.2	-0.5	0.1
Hair Pigment	0.0	0.1	0.1	0.2	-0.3
Hand grip strength (left)	0.0	0.0	0.1	-0.3	-0.1
Systolic blood pressure, automated reading	0.0	0.1	0.1	0.2	-0.3
Diabetes (mother)	0.0	0.1	0.1	0.3	-0.2
Chronic bronchitis/emphysema (father)	0.0	0.0	0.0	0.1	0.2
Had menopause	0.0	0.0	0.0	-0.0	-0.2
Neuroticism score	0.0	0.0	0.1	0.3	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.1	0.3	-0.1
High blood pressure (siblings)	0.0	0.0	0.0	0.2	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	0.0	-0.2
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	0.1	-0.0
Medication: Allopurinol	0.0	0.0	0.0	0.2	-0.2
Mean time to correctly identify matches	0.0	0.0	0.1	-0.3	0.1
Comparative height size at age 10	0.0	0.1	0.1	0.3	-0.1
Knee pain experienced in last month	0.0	0.0	0.0	0.2	-0.2
Smoking status: Previous	0.0	0.1	0.1	0.1	0.3
Osteoarthritis (self-reported)	0.0	0.0	0.1	0.1	0.3
Illnesses of father: None of the above (group 1)	0.0	0.0	0.0	-0.1	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.0	-0.1	-0.2

Hub : Genes

PIM3

Models

Trait associations