Hub : Traits :

Seen doctor (GP) for nerves, anxiety, tension or depression

35 significantly associated models · 16 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 66304567 67938108 2 1 2.9e-12 5.0e-09 0.48000 98 SGIP1
2 1 71163715 73435171 1 1 3.6e-11 6.8e-14 0.00015 74 NEGR1
3 2 152280365 153725785 1 1 3.9e-07 5.2e-05 0.27100 93 STAM2
4 3 43682052 45387691 2 1 3.1e-07 2.8e-06 0.58100 99 ZNF197
5 6 147140769 148587096 1 1 6.7e-08 2.1e-06 0.64300 99 SAMD5
6 7 11553163 12967449 1 1 2.5e-10 2.4e-12 0.00161 80 TMEM106B
7 9 125453469 127385609 1 1 2.0e-07 1.2e-06 0.00042 47 DENND1A
8 11 65670510 67070766 1 1 1.4e-07 1.7e-07 1.00000 100 CCS
9 11 89240503 90652993 1 1 8.9e-09 1.4e-07 0.00416 70 CHORDC1
10 13 31078511 32595740 1 1 3.4e-08 7.8e-08 0.19200 94 B3GALTL
11 16 20915247 22360385 3 1 2.1e-09 1.3e-08 0.16100 94 METTL9
12 18 52209411 54028036 1 1 4.5e-08 1.1e-09 0.00083 70 TCF4

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Major Depression (MDD) 7.37 4 1 3.0 -0.99 7.6e-03 B3GALTL NEGR1 TCF4 TMEM106B
Verbal and Numeric Reasoning (VNR) 3.47 1 1 3.0 0.00 1.0e+00 NEGR1
Breast Cancer 1.11 1 0 0.0 0.00 1.0e+00 NEGR1
Body Mass Index (BMI) (2010) 4.56 1 1 3.0 0.00 1.0e+00 NEGR1
Neuroticism 3.50 2 0 0.0 0.00 1.0e+00 TCF4 ZNF197
Blood Platelet Count 0.21 1 0 0.0 0.00 1.0e+00 SAMD5
Blood Red Count 0.69 1 1 3.0 0.00 1.0e+00 CCS
Blood White Count 0.39 1 0 0.0 0.00 1.0e+00 SGIP1
Heel T-Score 1.39 5 3 9.1 0.00 1.0e+00 B3GALTL CCS NEGR1 STAM2 TCF4
BMI 2.90 4 1 3.0 -0.87 1.3e-01 CCS CHORDC1 NEGR1 TMEM106B
Height 0.80 3 3 9.1 0.00 1.0e+00 CCS TCF4 TMEM106B
Systolic Blood Pressure 1.47 3 1 3.0 0.00 1.0e+00 B3GALTL METTL9 SGIP1
Allergy or Eczema 1.72 1 0 0.0 0.00 1.0e+00 NEGR1
Cardiovascular Disease 1.86 4 1 3.0 -0.31 6.9e-01 CCS NEGR1 SGIP1 TMEM106B
Respiratory disease 2.11 2 0 0.0 0.00 1.0e+00 CCS NEGR1
Lung FEV1/FVC ratio 0.98 1 1 3.0 0.00 1.0e+00 NEGR1
Lung FVC 1.02 2 1 3.0 0.00 1.0e+00 SAMD5 TCF4
Neuroticism 5.54 5 2 6.1 -0.98 4.0e-03 B3GALTL SAMD5 TCF4 TMEM106B ZNF197
Chronotype (morning person) 2.67 3 0 0.0 0.00 1.0e+00 DENND1A SAMD5 TCF4
Hair Pigment 0.16 1 1 3.0 0.00 1.0e+00 DENND1A
Tanning 0.28 2 0 0.0 0.00 1.0e+00 NEGR1 TCF4
Hand grip strength (left) 2.04 2 2 6.1 0.00 1.0e+00 CCS TCF4
Number of treatments/medications taken 4.33 4 0 0.0 0.98 1.7e-02 B3GALTL CCS NEGR1 SAMD5
Frequency of depressed mood in last 2 weeks 5.96 4 1 3.0 1.00 4.6e-04 B3GALTL CHORDC1 TMEM106B ZNF197
Hearing difficulty/problems: Yes 2.13 1 0 0.0 0.00 1.0e+00 CCS
Relative age of first facial hair 1.67 1 0 0.0 0.00 1.0e+00 NEGR1
Other serious medical condition/disability diagnosed by doctor 2.90 1 0 0.0 0.00 1.0e+00 NEGR1
Systolic blood pressure, automated reading 1.40 1 0 0.0 0.00 1.0e+00 SGIP1
Vitamin and mineral supplements 1.83 1 0 0.0 0.00 1.0e+00 NEGR1
Severe depression (siblings) 4.05 2 0 0.0 0.00 1.0e+00 NEGR1 SGIP1
Impedance of leg (right) 1.66 2 1 3.0 0.00 1.0e+00 CCS NEGR1
Leg fat-free mass (left) 0.78 1 1 3.0 0.00 1.0e+00 NEGR1
Trunk fat percentage 1.23 1 1 3.0 0.00 1.0e+00 NEGR1
Hand grip strength (right) 1.78 2 0 0.0 0.00 1.0e+00 CCS TCF4
Current tobacco smoking 0.87 1 0 0.0 0.00 1.0e+00 NEGR1
Fed-up feelings 2.97 2 0 0.0 0.00 1.0e+00 B3GALTL DENND1A
Frequency of unenthusiasm / disinterest in last 2 weeks 3.49 1 0 0.0 0.00 1.0e+00 TMEM106B
Taking other prescription medications 5.22 5 0 0.0 0.99 1.8e-03 CCS NEGR1 SAMD5 TCF4 TMEM106B
Age when periods started (menarche) 2.74 1 1 3.0 0.00 1.0e+00 NEGR1
High blood pressure 1.82 1 0 0.0 0.00 1.0e+00 NEGR1
Hayfever, allergic rhinitis or eczema 1.59 1 0 0.0 0.00 1.0e+00 NEGR1
Multivitamins +/- minerals 1.90 1 0 0.0 0.00 1.0e+00 NEGR1
Stomach or abdominal pain in last month 3.36 2 0 0.0 0.00 1.0e+00 NEGR1 SGIP1
Sitting height 0.69 3 0 0.0 0.00 1.0e+00 CCS TCF4 ZNF197
Body mass index (BMI) 2.48 3 1 3.0 0.00 1.0e+00 CCS NEGR1 TMEM106B
Impedance of leg (left) 1.66 2 1 3.0 0.00 1.0e+00 CCS NEGR1
Leg predicted mass (left) 0.77 1 1 3.0 0.00 1.0e+00 NEGR1
Trunk fat mass 1.32 1 1 3.0 0.00 1.0e+00 NEGR1
Waist circumference 1.86 2 1 3.0 0.00 1.0e+00 DENND1A NEGR1
Alcohol usually taken with meals 2.02 1 0 0.0 0.00 1.0e+00 NEGR1
Nervous feelings 3.46 3 0 0.0 0.00 1.0e+00 B3GALTL METTL9 TCF4
Frequency of tenseness / restlessness in last 2 weeks 6.58 5 0 0.0 0.98 2.7e-03 B3GALTL SGIP1 TCF4 TMEM106B ZNF197
Hearing difficulty/problems with background noise 2.38 1 0 0.0 0.00 1.0e+00 DENND1A
Forced vital capacity (FVC) 1.39 1 1 3.0 0.00 1.0e+00 CCS
Qualifications: None of the above 2.58 2 1 3.0 0.00 1.0e+00 B3GALTL NEGR1
Financial difficulties in last 2 years 2.50 1 0 0.0 0.00 1.0e+00 TMEM106B
Allergy 2.09 2 0 0.0 0.00 1.0e+00 CCS NEGR1
Pain all over the body in last month 2.35 1 0 0.0 0.00 1.0e+00 SAMD5
Fluid intelligence score 2.61 1 1 3.0 0.00 1.0e+00 NEGR1
Neuroticism score 5.79 5 2 6.1 0.98 2.9e-03 B3GALTL SAMD5 TCF4 TMEM106B ZNF197
Weight 1.29 1 1 3.0 0.00 1.0e+00 NEGR1
Impedance of arm (right) 1.50 4 1 3.0 -0.99 1.2e-02 NEGR1 SAMD5 TMEM106B ZNF197
Arm fat percentage (right) 2.16 2 2 6.1 0.00 1.0e+00 CCS NEGR1
Trunk fat-free mass 0.56 2 0 0.0 0.00 1.0e+00 NEGR1 ZNF197
Hip circumference 1.36 1 1 3.0 0.00 1.0e+00 NEGR1
Alcohol intake versus 10 years previously 2.68 2 0 0.0 0.00 1.0e+00 NEGR1 TMEM106B
Worrier / anxious feelings 4.56 3 1 3.0 0.00 1.0e+00 B3GALTL TCF4 TMEM106B
Frequency of tiredness / lethargy in last 2 weeks 4.82 5 0 0.0 1.00 1.1e-04 B3GALTL CCS SAMD5 TMEM106B ZNF197
Hair/balding pattern: Pattern 3 1.54 1 0 0.0 0.00 1.0e+00 METTL9
Forced expiratory volume in 1-second (FEV1) 1.56 1 1 3.0 0.00 1.0e+00 CCS
Qualifications: A levels/AS levels or equivalent 1.87 1 1 3.0 0.00 1.0e+00 NEGR1
Mouth/teeth dental problems: Dentures 1.83 1 0 0.0 0.00 1.0e+00 NEGR1
Asthma 1.88 1 0 0.0 0.00 1.0e+00 CCS
Depression (self-reported) 5.90 2 0 0.0 0.00 1.0e+00 B3GALTL TMEM106B
Forced expiratory volume in 1-second (FEV1), Best measure 1.30 1 0 0.0 0.00 1.0e+00 CCS
Impedance of arm (left) 1.50 3 1 3.0 0.00 1.0e+00 NEGR1 TMEM106B ZNF197
Arm fat mass (right) 2.05 2 1 3.0 0.00 1.0e+00 CCS NEGR1
Trunk predicted mass 0.59 2 0 0.0 0.00 1.0e+00 NEGR1 ZNF197
Standing height 0.85 3 1 3.0 0.00 1.0e+00 CCS TCF4 TMEM106B
Tense / 'highly strung' 5.35 5 2 6.1 0.97 4.8e-03 B3GALTL SAMD5 SGIP1 TMEM106B ZNF197
Hair/balding pattern: Pattern 4 1.20 1 0 0.0 0.00 1.0e+00 METTL9
Peak expiratory flow (PEF) 1.32 1 0 0.0 0.00 1.0e+00 CCS
Headache pain in last month 2.19 1 0 0.0 0.00 1.0e+00 ZNF197
Medication for cholesterol, blood pressure or diabetes 1.79 1 0 0.0 0.00 1.0e+00 NEGR1
Glaucoma (self-reported) 1.80 1 0 0.0 0.00 1.0e+00 STAM2
Birth weight 0.99 1 0 0.0 0.00 1.0e+00 CCS
High blood pressure (siblings) 1.88 1 0 0.0 0.00 1.0e+00 TMEM106B
Forced vital capacity (FVC), Best measure 1.22 1 1 3.0 0.00 1.0e+00 CCS
Body fat percentage 1.64 1 1 3.0 0.00 1.0e+00 NEGR1
Leg fat percentage (right) 2.03 1 1 3.0 0.00 1.0e+00 NEGR1
Arm fat-free mass (right) 1.04 2 1 3.0 0.00 1.0e+00 NEGR1 ZNF197
Comparative body size at age 10 4.31 2 1 3.0 0.00 1.0e+00 B3GALTL NEGR1
Worry too long after embarrassment 2.63 2 0 0.0 0.00 1.0e+00 CHORDC1 ZNF197
Seen a psychiatrist for nerves, anxiety, tension or depression 9.54 7 1 3.0 0.99 8.3e-06 DENND1A METTL9 NEGR1 SAMD5 SGIP1 TCF4 TMEM106B
Wheeze or whistling in the chest in last year 2.29 1 0 0.0 0.00 1.0e+00 DENND1A
Health satisfaction 2.43 1 0 0.0 0.00 1.0e+00 CCS
Shortness of breath walking on level ground 2.85 2 0 0.0 0.00 1.0e+00 CCS SGIP1
Qualifications: College or University degree 3.81 2 1 3.0 0.00 1.0e+00 B3GALTL NEGR1
Medication: Blood pressure 1.38 1 0 0.0 0.00 1.0e+00 NEGR1
Angina (self-reported) 1.76 1 0 0.0 0.00 1.0e+00 TMEM106B
Medication: Omeprazole 2.41 1 0 0.0 0.00 1.0e+00 SAMD5
Whole body fat mass 1.71 1 1 3.0 0.00 1.0e+00 NEGR1
Leg fat mass (right) 2.16 1 1 3.0 0.00 1.0e+00 NEGR1
Arm predicted mass (right) 1.03 2 1 3.0 0.00 1.0e+00 NEGR1 ZNF197
Pulse rate, automated reading 1.88 2 1 3.0 0.00 1.0e+00 NEGR1 SGIP1
Alcohol intake frequency. 3.28 3 1 3.0 0.00 1.0e+00 NEGR1 SGIP1 TCF4
Comparative height size at age 10 1.09 3 1 3.0 0.00 1.0e+00 CCS TCF4 TMEM106B
Suffer from 'nerves' 2.80 2 0 0.0 0.00 1.0e+00 B3GALTL TMEM106B
Overall health rating 3.61 4 0 0.0 0.98 1.8e-02 B3GALTL CCS SGIP1 TCF4
Chest pain or discomfort 3.18 1 0 0.0 0.00 1.0e+00 SAMD5
Commuting to job workplace: Car/motor vehicle 1.85 1 0 0.0 0.00 1.0e+00 NEGR1
Medication: Aspirin 1.57 1 0 0.0 0.00 1.0e+00 TMEM106B
Hypertension (Self-reported) 1.68 1 0 0.0 0.00 1.0e+00 NEGR1
Smoking status: Previous 1.87 1 0 0.0 0.00 1.0e+00 NEGR1
Whole body fat-free mass 0.64 1 1 3.0 0.00 1.0e+00 NEGR1
Leg fat-free mass (right) 0.66 1 1 3.0 0.00 1.0e+00 NEGR1
Arm fat percentage (left) 2.24 2 2 6.1 0.00 1.0e+00 CCS NEGR1
Average weekly red wine intake 1.52 1 0 0.0 0.00 1.0e+00 NEGR1
Handedness (chirality/laterality): Left-handed 2.08 1 0 0.0 0.00 1.0e+00 STAM2
Mood swings 6.66 4 2 6.1 0.95 5.1e-02 B3GALTL TCF4 TMEM106B ZNF197
Loneliness, isolation 3.11 2 0 0.0 0.00 1.0e+00 CHORDC1 TMEM106B
Long-standing illness, disability or infirmity 4.97 3 0 0.0 0.00 1.0e+00 DENND1A NEGR1 TMEM106B
Qualifications: nursing, teaching 2.99 2 1 3.0 0.00 1.0e+00 B3GALTL NEGR1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.44 1 0 0.0 0.00 1.0e+00 ZNF197
Asthma (self-reported) 1.93 1 0 0.0 0.00 1.0e+00 CCS
Osteoporosis (self-reported) 1.73 1 0 0.0 0.00 1.0e+00 TCF4
Osteoarthritis (self-reported) 1.51 1 0 0.0 0.00 1.0e+00 NEGR1
Medication: Aspirin 1.45 1 0 0.0 0.00 1.0e+00 TMEM106B
Smoking status: Current 0.82 1 0 0.0 0.00 1.0e+00 NEGR1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.04 1 0 0.0 0.00 1.0e+00 DENND1A
Whole body water mass 0.66 1 1 3.0 0.00 1.0e+00 NEGR1
Leg predicted mass (right) 0.66 1 1 3.0 0.00 1.0e+00 NEGR1
Arm fat mass (left) 1.98 2 1 3.0 0.00 1.0e+00 CCS NEGR1
Number of self-reported non-cancer illnesses 5.81 4 1 3.0 0.81 1.9e-01 CCS DENND1A NEGR1 TMEM106B
Miserableness 5.74 3 2 6.1 0.00 1.0e+00 B3GALTL TCF4 TMEM106B
Guilty feelings 3.58 1 0 0.0 0.00 1.0e+00 TCF4
Commuting to job workplace: Public transport 1.81 1 0 0.0 0.00 1.0e+00 NEGR1
Eye problems/disorders: Glaucoma 1.35 1 0 0.0 0.00 1.0e+00 STAM2
Basal metabolic rate 0.77 1 1 3.0 0.00 1.0e+00 NEGR1
Leg fat percentage (left) 1.98 1 1 3.0 0.00 1.0e+00 NEGR1
Arm fat-free mass (left) 1.04 2 1 3.0 0.00 1.0e+00 NEGR1 ZNF197
Number of operations (self-reported) 3.47 2 1 3.0 0.00 1.0e+00 NEGR1 SAMD5
Average weekly beer plus cider intake 1.15 1 0 0.0 0.00 1.0e+00 NEGR1
Irritability 4.13 3 1 3.0 0.00 1.0e+00 SAMD5 TCF4 TMEM106B
Risk taking 1.72 1 0 0.0 0.00 1.0e+00 TMEM106B
Ever depressed for a whole week 3.76 1 0 0.0 0.00 1.0e+00 TMEM106B
Commuting to job workplace: Cycle 3.49 3 0 0.0 0.00 1.0e+00 NEGR1 TCF4 ZNF197
Myopia 2.02 1 0 0.0 0.00 1.0e+00 ZNF197
Vascular/heart problems diagnosed by doctor 1.73 2 0 0.0 0.00 1.0e+00 NEGR1 TMEM106B
Medication: Omeprazole (e.g. Zanprol) 2.43 1 0 0.0 0.00 1.0e+00 SAMD5
Impedance of whole body 1.39 3 1 3.0 0.00 1.0e+00 CCS NEGR1 TMEM106B
Leg fat mass (left) 2.14 1 1 3.0 0.00 1.0e+00 NEGR1
Arm predicted mass (left) 1.02 2 1 3.0 0.00 1.0e+00 NEGR1 ZNF197

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.0573 1.53
GTEx Adipose Visceral Omentum 1 0.0491 1.56
GTEx Adrenal Gland 0 0.0000 1.50
GTEx Artery Aorta 1 0.0336 1.56
GTEx Artery Coronary 0 0.0000 1.57
GTEx Artery Tibial 0 0.0000 1.56
GTEx Brain Caudate basal ganglia 0 0.0000 1.52
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.50
GTEx Brain Cerebellum 0 0.0000 1.56
GTEx Brain Cortex 2 0.1932 1.65
GTEx Brain Frontal Cortex BA9 0 0.0000 1.48
GTEx Brain Hippocampus 1 0.1908 1.63
GTEx Brain Hypothalamus 0 0.0000 1.48
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.52
GTEx Brain Putamen basal ganglia 1 0.1603 1.49
GTEx Breast Mammary Tissue 0 0.0000 1.58
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.42
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.60
GTEx Cells EBV-transformed lymphocytes 1 0.0703 1.61
GTEx Cells Transformed fibroblasts 2 0.0476 1.58
GTEx Colon Sigmoid 0 0.0000 1.62
GTEx Colon Transverse 2 0.0969 1.58
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.56
GTEx Esophagus Mucosa 0 0.0000 1.54
GTEx Esophagus Muscularis 2 0.0619 1.58
GTEx Heart Atrial Appendage 0 0.0000 1.56
GTEx Heart Left Ventricle 1 0.0654 1.52
GTEx Liver 0 0.0000 1.38
GTEx Lung 3 0.1044 1.63
GTEx Muscle Skeletal 1 0.0346 1.60
GTEx Nerve Tibial 1 0.0231 1.55
GTEx Ovary 0 0.0000 1.65
GTEx Pancreas 0 0.0000 1.53
GTEx Pituitary 0 0.0000 1.58
GTEx Prostate 0 0.0000 1.48
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.59
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.54
GTEx Small Intestine Terminal Ileum 0 0.0000 1.79
GTEx Spleen 0 0.0000 1.64
GTEx Stomach 0 0.0000 1.58
GTEx Testis 2 0.0634 1.57
GTEx Thyroid 1 0.0250 1.56
GTEx Uterus 0 0.0000 1.58
GTEx Vagina 1 0.1575 1.65
GTEx Whole Blood 1 0.0502 1.53
METSIM Adipose 1 0.0217 1.51
NTR Blood 2 0.0833 1.58
ROSMAP Brain Pre-frontal Cortex 3 0.0683 1.62
YFS Blood 1 0.0217 1.51
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.60
TCGA Breast Tumor 0 0.0000 1.39
TCGA Breast Normal 0 0.0000 1.38
TCGA Ovarian Tumor 0 0.0000 1.43
TCGA Prostate Tumor 1 0.0289 1.48