TWAS hub - PAX5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0797	0.0302	0.00051	-0.002	0.021	0.003	0.013	-0.002	0.69	0.00036	0.11	0.0042	0.770
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0507	0.0252	0.00940	0.004	0.021	0.001	NA	0.007	0.11	0.00190	0.26	NA	0.052

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Chronotype (morning person)	11.3	26.2	42.1	3.2	-6.5
Seen doctor (GP) for nerves, anxiety, tension or depression	9.1	14.0	27.3	0.8	-5.2
Alzheimer’s Disease (in mother)	8.9	10.4	19.0	1.4	-4.4
Neuroticism (2016)	7.3	10.5	17.3	1.9	-4.2
Schizophrenia vs Biploar Disorder	7.2	9.5	15.4	-1.9	3.9
Schizophrenia (2014)	5.9	12.9	19.5	-2.5	4.4
Alzheimer’s Disease (including proxy)	5.7	8.2	15.8	0.8	-4.0
Neuroticism	5.4	13.0	26.0	0.2	-5.1
Type 2 Diabetes (T2D) (2018)	5.3	9.9	16.9	1.7	-4.1
Seen a psychiatrist for nerves, anxiety, tension or depression	5.1	6.6	13.0	-0.3	-3.6
Neuroticism (Nagel 2018)	5.0	11.7	23.1	0.5	-4.8
Noisy workplace	4.9	6.0	8.7	3.0	-1.8
Irritability	4.9	8.4	15.7	-1.0	-4.0
BMI	4.7	27.1	52.7	-1.2	-7.3
Diastolic blood pressure, automated reading	4.4	13.6	21.5	2.4	-4.6
Mood swings	4.2	7.6	14.9	0.5	-3.9
Arm fat percentage (right)	4.1	16.1	31.8	0.6	-5.6
Maternal smoking around birth	4.0	5.8	8.9	-1.6	3.0
Mouth/teeth dental problems: Loose teeth	3.9	4.7	7.4	-1.4	2.7
Neuroticism score	3.8	8.0	15.9	-0.1	-4.0
Arm fat percentage (left)	3.8	15.1	30.0	0.3	-5.5
Diabetes diagnosed by doctor	3.8	6.3	12.3	0.5	-3.5
Schizophrenia (2018)	3.7	7.7	13.1	-1.5	3.6
Body mass index (BMI)	3.6	15.2	29.8	-0.8	-5.5
Medication: Co-codamol	3.5	4.0	8.1	0.0	-2.8
Nervous feelings	3.5	6.6	13.1	0.1	-3.6
Diabetes (self-reported)	3.5	5.4	9.9	0.9	-3.1
Arm fat mass (left)	3.5	14.5	28.9	-0.3	-5.4
Waist circumference	3.4	12.3	23.6	-1.0	-4.9
Glaucoma (self-reported)	3.4	4.0	4.2	2.0	-1.9
Leg pain on walking	3.4	4.2	4.4	2.0	-2.1
Illnesses of siblings: Diabetes	3.4	4.2	7.8	-0.7	-2.8
Number of operations (self-reported)	3.4	5.0	7.9	-2.8	-1.5
Worrier / anxious feelings	3.3	6.3	12.4	-0.4	-3.5
Arm fat mass (right)	3.3	13.5	26.9	0.1	-5.2
Leg fat mass (left)	3.3	12.8	25.6	-0.1	-5.1
Lung cancer (father)	3.2	3.7	3.8	-1.9	1.9
Health satisfaction	3.2	4.1	8.2	0.0	-2.9
Depressed Affect (Nagel 2018)	3.1	6.6	13.0	0.5	-3.6
Leg fat mass (right)	3.1	12.2	24.4	-0.1	-4.9
Average weekly champagne plus white wine intake	3.1	4.3	6.1	1.6	-2.5
Medication: Blood pressure	3.1	6.0	11.5	-0.7	-3.4
Leg fat percentage (left)	3.1	11.1	22.1	-0.3	-4.7
LDL Cholesterol	3.0	4.7	5.6	-1.9	2.4
Tense / ‘highly strung’	3.0	5.0	6.0	-2.0	-2.4
Whole body fat mass	3.0	12.7	25.4	0.0	-5.0
Number of treatments/medications taken	2.9	5.2	5.3	-2.2	-2.3
Ever unenthusiastic/disinterested for a whole week	2.9	3.5	6.3	0.9	-2.5
Body fat percentage	2.9	11.3	22.7	0.1	-4.8
Leg fat percentage (right)	2.9	10.4	20.8	-0.3	-4.6
Shortness of breath walking on level ground	2.9	3.4	6.0	0.9	-2.4
Pack years of smoking	2.9	4.3	4.7	-2.0	2.2
Worry (Nagel 2018)	2.8	5.9	11.7	0.3	-3.4
Chronic bronchitis/emphysema (father)	2.8	3.3	6.5	-0.3	-2.5
Unable to work because of sickness or disability	2.8	3.7	6.4	1.0	-2.5
Breast Cancer	2.7	6.6	7.0	2.6	-2.5
Trunk fat mass	2.7	11.6	23.1	-0.1	-4.8
Breastfed as a baby	2.7	3.4	4.8	2.2	-1.4
Medication: Simvastatin	2.6	3.9	5.1	1.6	-2.3
Alcohol drinker status: Never	2.6	3.1	6.2	-2.5	-0.2
Hand grip strength (left)	2.5	6.7	9.0	-2.1	3.0
Pack years adult smoking proportion	2.5	3.8	4.5	-2.1	1.7
Worry too long after embarrassment	2.5	4.3	8.2	-0.6	-2.9
Hypertension (Self-reported)	2.5	7.1	13.5	0.8	-3.7
Cardiovascular Disease	2.4	7.8	13.2	1.5	-3.6
Frequency of depressed mood in last 2 weeks	2.4	3.3	6.1	-0.7	-2.5
Trunk fat percentage	2.4	9.5	18.9	0.0	-4.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.2	6.1	-2.5	-0.5
High blood pressure	2.4	6.7	13.0	0.6	-3.6
Loud music exposure frequency	2.3	2.5	4.7	-2.2	0.6
Medication: Amlodipine	2.3	3.2	4.6	2.1	-1.3
Eye problems/disorders: Glaucoma	2.3	2.7	3.2	1.8	-1.5
Medication: Metformin	2.2	3.1	5.8	0.7	-2.4
Exposure to tobacco smoke at home	2.2	2.4	3.5	-1.9	1.2
Tinnitus: Yes, now most or all of the time	2.2	2.6	2.8	1.5	-1.7
Pain type(s) experienced in last month: Hip pain	2.2	2.8	3.0	1.7	-1.6
Ever smoked	2.2	3.9	7.7	0.2	2.8
Alcohol drinker status: Previous	2.2	2.5	2.8	1.5	-1.7
HbA1C	2.1	2.4	4.6	0.4	-2.1
Frequency of tenseness / restlessness in last 2 weeks	2.1	3.2	3.8	-1.9	-1.6
Weight	2.1	10.2	20.0	-0.7	-4.5
Hip circumference	2.1	8.9	17.7	-0.1	-4.2
Medication for cholesterol	2.1	3.2	6.0	0.7	2.5
Guilty feelings	2.1	3.1	5.9	-0.6	-2.4
Bipolar Disorder or Schizophrenia	2.0	4.8	6.2	-1.9	2.5
Major Depression (MDD)	2.0	2.4	3.6	1.1	-1.9
Body Mass Index (BMI) (2010)	2.0	2.7	4.5	1.0	-2.1
Illnesses of mother	2.0	2.5	5.1	0.0	2.2
Hand grip strength (right)	1.9	5.1	8.3	-1.4	2.9
Birth weight of first child	1.9	3.5	5.4	2.3	-1.3
Osteoporosis (self-reported)	1.9	2.4	4.4	-0.6	2.1
Past tobacco smoking	1.8	3.4	6.8	0.1	-2.6
Alcohol usually taken with meals	1.8	2.8	4.4	2.1	-1.1
Heart disease (mother)	1.8	2.1	2.5	1.6	-1.3
Illnesses of father: High blood pressure	1.8	2.3	3.9	0.8	-2.0
Vascular/heart problems diagnosed by doctor	1.8	4.9	9.7	-0.0	3.1
Supplements: Calcium	1.8	2.0	2.9	-1.7	-1.0
Mouth/teeth dental problems	1.7	2.6	3.4	1.3	-1.8
Medication: Ramipril	1.7	2.1	2.4	1.6	-1.4
Number of live births	1.7	2.4	2.8	1.7	-1.4
Medication: Blood pressure	1.7	2.9	3.8	2.0	-1.4
Pulse rate, automated reading	1.7	5.4	7.6	2.8	-1.8
Supplements: Vitamin C	1.7	2.0	3.6	0.6	-1.9
Medication: Bendroflumethiazide	1.7	2.5	5.0	0.2	-2.2
Risk taking	1.7	2.5	3.2	-1.4	1.8
Had other major operations	1.6	2.0	3.6	-1.9	0.6
Mouth/teeth dental problems: Bleeding gums	1.6	2.0	3.2	-0.9	1.8
Leg fat-free mass (left)	1.5	7.7	15.4	-0.3	-3.9
Taking other prescription medications	1.5	2.3	2.6	-1.4	-1.6
Had menopause	1.5	1.9	2.4	-1.6	1.2
Illnesses of siblings	1.5	2.1	3.9	0.6	2.0
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	3.4	1.9	0.1
Medication for pain relief, constipation, heartburn	1.5	2.6	4.8	0.7	2.2
Commuting to job workplace: Walk	1.5	1.7	3.3	1.8	0.1
Number of self-reported non-cancer illnesses	1.5	2.6	4.5	-0.9	-2.1
Supplements: Fish oil (including cod liver oil)	1.5	2.0	3.5	-1.9	0.7
Commuting to job workplace: Cycle	1.5	1.8	3.2	0.6	-1.8
Hypothyroidism (self reported)	1.4	3.2	3.4	1.8	-1.8
Leg predicted mass (left)	1.4	7.7	15.2	-0.4	-3.9
Pulse wave Arterial Stiffness index	1.4	1.6	3.0	0.5	1.7
Illnesses of father: None of the above (group 1)	1.4	1.7	2.5	-1.0	1.6
Medication: Atorvastatin	1.4	1.7	1.9	-1.2	1.4
Basal metabolic rate	1.4	7.7	15.1	-0.4	-3.9
Ulcerative Colitis	1.3	1.9	3.7	1.9	-0.1
Heart attack	1.3	1.7	3.3	-1.8	-0.3
Leg fat-free mass (right)	1.3	6.7	13.3	-0.4	-3.6
Leg predicted mass (right)	1.3	6.8	13.5	-0.3	-3.7
Ever taken oral contraceptive pill	1.3	1.5	2.8	1.7	0.4
Hearing aid user	1.3	1.4	1.6	1.3	-1.1
Depression (Nagel 2018)	1.2	1.8	3.7	-0.1	-1.9
Sensitivity / hurt feelings	1.2	2.1	4.2	-0.3	-2.0
Angina	1.2	1.6	3.2	-1.8	-0.1
Diabetes (mother)	1.2	1.5	1.6	-1.2	-1.3
Severe depression (siblings)	1.2	1.4	1.7	1.3	-1.0
Pain all over the body in last month	1.2	1.3	2.3	-1.5	-0.4
Blood clot in the leg (DVT)	1.2	1.5	1.9	-1.1	1.4
Pulse wave peak to peak time	1.2	1.4	2.6	-0.5	-1.6
Emphysema/chronic bronchitis	1.2	1.3	2.7	0.0	-1.6
Knee pain experienced in last month	1.2	1.9	3.9	-0.1	-2.0
Osteoarthritis (self-reported)	1.2	1.5	3.0	0.2	-1.7
Miserableness	1.2	2.2	4.1	-0.4	-2.0
Arm fat-free mass (left)	1.2	6.1	11.6	-0.8	-3.4
Systolic blood pressure, automated reading	1.1	3.2	6.3	-0.0	-2.5
Mouth/teeth dental problems: Dentures	1.1	1.8	2.9	-1.7	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.4	2.3	-0.6	1.5
Chest pain or discomfort	1.1	1.6	3.1	-1.8	0.3
Smoking status: Previous	1.1	1.7	2.5	0.9	1.6
Loneliness, isolation	1.1	1.5	3.1	-1.8	-0.0
Back pain experienced in last month	1.1	1.6	1.8	-1.2	1.3
Medication: Aspirin	1.1	1.5	1.6	-1.3	-1.1
Medication: Paracetamol	1.1	1.7	1.9	-1.2	-1.4
Arm predicted mass (left)	1.1	5.7	11.4	-0.3	-3.4
Triglycerides	1.0	1.6	2.9	-1.7	0.6
Fed-up feelings	1.0	1.7	3.3	-0.4	-1.8
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.0	-1.4	-0.6
Impedance of arm (right)	1.0	4.5	5.6	2.4	1.9
Depression (self-reported)	1.0	1.2	1.9	0.8	-1.4
Impedance of arm (left)	1.0	4.5	7.0	1.4	2.7
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	1.9	-1.4	1.2
High blood pressure (siblings)	1.0	1.5	2.9	0.2	-1.7
Arm fat-free mass (right)	1.0	5.1	8.6	-1.2	-2.9
Angina (self-reported)	1.0	1.3	2.6	-1.6	-0.2
Medication: Aspirin	1.0	1.3	1.7	-0.9	-1.3
Illnesses of father: Heart disease	1.0	1.4	2.8	1.7	-0.2
Whole body fat-free mass	1.0	5.9	11.6	-0.4	-3.4
Long-standing illness, disability or infirmity	1.0	1.6	2.8	-1.7	-0.6
Mineral and other dietary supplements	1.0	1.4	2.1	1.4	-0.8
Whole body water mass	1.0	5.8	11.5	-0.4	-3.4
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.3	-1.5	-0.4
Impedance of whole body	1.0	5.3	8.7	1.4	2.9
Alzheimer’s Disease (in father)	0.9	1.0	1.8	0.5	-1.3
HDL Cholesterol	0.9	1.4	2.3	1.5	-0.7
Smoking Status	0.9	2.3	4.5	-0.1	2.1
Average weekly spirits intake	0.9	1.1	1.5	-0.9	1.2
Ever had hysterectomy (womb removed)	0.9	1.0	1.8	-1.3	0.5
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.2	-1.1	0.9
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	1.1	-1.1	0.9
High blood pressure (mother)	0.9	1.3	1.7	-0.9	-1.3
Qualifications: None of the above	0.9	1.9	2.9	-1.7	1.0
Medication: Paracetamol	0.9	1.5	1.8	-1.1	-1.3
Arm predicted mass (right)	0.9	4.4	7.4	-1.2	-2.7
Ever had bowel cancer screening	0.9	1.0	2.0	-1.4	-0.0
Age when periods started (menarche)	0.8	2.0	2.1	1.4	1.5
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	1.5	-1.2	-0.6
Impedance of leg (left)	0.8	4.0	7.0	1.0	2.6
Hair/balding pattern: Pattern 2	0.8	1.1	1.4	-1.2	-0.8
Trunk fat-free mass	0.8	4.3	8.6	-0.3	-2.9
Alcohol intake versus 10 years previously	0.8	1.1	2.2	-1.5	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.4	-0.5	-1.5
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	1.6	1.3	-1.2
Wheeze or whistling in the chest in last year	0.8	1.5	2.8	0.4	-1.7
Had major operations	0.8	1.0	1.9	-1.4	0.2
Breast cancer (self-reported)	0.8	0.9	1.9	-0.1	1.4
Medication: Lisinopril	0.8	1.0	1.0	1.0	-1.0
Systolic Blood Pressure	0.7	3.4	6.4	0.7	-2.5
Impedance of leg (right)	0.7	3.6	6.8	0.7	2.6
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	1.5	0.4	-1.2
Prospective memory result	0.7	0.8	1.3	0.5	-1.2
Trunk predicted mass	0.7	4.2	8.4	-0.4	-2.9
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.1	1.4	-0.4
Number of children fathered	0.7	0.8	1.0	1.0	0.8
Qualifications: College or University degree	0.7	2.3	4.4	2.1	0.4
Overall health rating	0.7	1.5	2.5	-0.7	-1.6
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.0	-0.9	1.0
Rheumatoid Arthritis	0.6	0.8	1.5	1.2	-0.2
Forced vital capacity (FVC)	0.6	2.2	3.3	1.8	1.1
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	3.0	1.7	1.0
Pulse rate	0.6	1.0	2.0	1.4	-0.0
Medication: Ibuprofen	0.6	0.7	1.4	0.2	-1.2
Alcohol intake frequency.	0.6	1.3	1.6	-1.0	-1.3
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.2	-0.5	1.1
Average weekly red wine intake	0.6	0.8	1.2	1.1	0.7
Handedness (chirality/laterality): Left-handed	0.6	0.7	0.7	0.8	-0.9
Age started oral contraceptive pill	0.6	0.8	1.2	-1.1	0.6
Blood Red Count	0.5	4.4	6.9	1.4	-2.6
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.3	1.5	-0.2
Pulse wave reflection index	0.5	0.6	1.2	-0.4	1.1
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.1	0.1	-1.1
Birth weight	0.5	1.0	1.5	0.7	-1.2
Number of full brothers	0.5	0.6	1.2	1.1	0.1
Age at first live birth	0.5	1.0	1.3	0.8	1.2
Eye problems/disorders: None of the above	0.5	0.6	1.1	-0.2	1.1
Suffer from ‘nerves’	0.5	0.8	1.0	0.8	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.0	0.3	1.0
Heart disease (siblings)	0.5	0.7	0.8	0.9	-0.7
Bipolar Disorder (2018)	0.4	0.6	0.9	-0.9	-0.5
Prostate Cancer	0.4	0.6	1.3	-0.0	1.1
Lupus	0.4	0.6	1.0	1.0	-0.5
Heel T-Score	0.4	3.5	4.2	2.1	-1.6
Lung FVC	0.4	2.1	2.9	1.2	1.7
Ever used hormone-replacement therapy (HRT)	0.4	0.6	0.8	-0.9	0.5
Townsend deprivation index at recruitment	0.4	0.6	1.1	-0.3	1.0
Average weekly fortified wine intake	0.4	0.5	1.0	1.0	0.1
Medication: Levothyroxine sodium	0.4	0.7	1.2	0.5	-1.1
Time employed in main current job	0.4	0.5	1.0	-0.1	1.0
Medication: Cholesterol lowering	0.4	0.6	0.7	0.7	-0.8
Medication: Lansoprazole	0.4	0.5	0.9	-0.4	0.9
Peak expiratory flow (PEF)	0.4	0.9	1.3	1.1	0.8
Headache pain in last month	0.4	0.6	1.2	-0.1	-1.1
Forced vital capacity (FVC), Best measure	0.4	1.3	1.8	0.9	1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.9	-0.9	0.1
Migraine (self-reported)	0.4	0.5	0.9	-0.4	-0.9
Age at last live birth	0.4	0.5	1.0	-0.2	1.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	0.5	0.6	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.5	1.2	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.6	-0.5	-0.8
Commuting to job workplace: Public transport	0.4	0.5	1.0	-1.0	0.0
Average weekly beer plus cider intake	0.4	0.5	1.0	-1.0	0.3
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.0	-0.2	-1.0
Ulcerative Colitis (UC)	0.3	0.5	0.9	1.0	-0.4
Age at First Birth	0.3	0.4	0.8	-0.1	-0.9
Mean Putamen Volume	0.3	0.3	0.6	-0.8	-0.0
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.6	-0.8	-0.4
Respiratory disease	0.3	0.6	0.8	-0.6	-0.9
Relative age of first facial hair	0.3	0.6	1.1	0.3	1.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.8	-0.1	-0.9
Vitamin and mineral supplements	0.3	0.4	0.5	0.6	0.7
Current tobacco smoking	0.3	0.5	0.9	-0.9	0.2
Multivitamins +/- minerals	0.3	0.4	0.7	-0.8	0.2
Number of incorrect matches in round	0.3	0.5	0.5	0.7	0.7
Financial difficulties in last 2 years	0.3	0.4	0.5	-0.7	-0.5
Falls in the last year	0.3	0.4	0.8	-0.9	-0.1
Gout (self-reported)	0.3	0.4	0.4	-0.6	-0.6
Exposure to tobacco smoke outside home	0.3	0.4	0.7	-0.8	0.1
Comparative body size at age 10	0.3	0.7	1.1	0.6	-1.1
Neck or shoulder pain in last month	0.3	0.4	0.7	-0.4	-0.8
Medication: Allopurinol	0.3	0.5	0.9	-0.9	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.5	-0.7	-0.6
Asthma (self-reported)	0.3	0.6	1.0	-1.0	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.1	1.0	0.5
Wears glasses or contact lenses	0.3	0.3	0.5	-0.7	0.3
Mother’s age at death	0.3	0.4	0.8	0.1	-0.9
Ever depressed for a whole week	0.3	0.4	0.7	0.2	-0.8
Cholesterol lowering medication	0.3	0.5	0.9	0.3	-0.9
Basal cell carcinoma (self-reported)	0.3	0.4	0.6	-0.3	0.8
Ovarian Cancer	0.2	0.3	0.5	0.2	-0.7
Bipolar Disorder (2011)	0.2	0.2	0.5	-0.7	0.0
Primary Biliary Cirrhosis	0.2	0.2	0.3	0.3	-0.6
Allergy or Eczema	0.2	0.6	1.1	-1.0	0.4
Lung FEV1/FVC ratio	0.2	1.1	1.8	0.6	-1.4
Supplements: Zinc	0.2	0.2	0.4	0.3	-0.6
Diabetes (father)	0.2	0.2	0.4	0.6	0.2
Qualifications: CSEs or equivalent	0.2	0.2	0.4	-0.7	0.2
Stomach or abdominal pain in last month	0.2	0.2	0.4	-0.6	-0.1
Supplements: Glucosamine	0.2	0.2	0.3	0.4	-0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	0.2	-0.6
Asthma	0.2	0.4	0.5	-0.7	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	0.9	0.7	0.9
Hair/balding pattern: Pattern 4	0.2	0.5	0.8	0.9	0.4
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.5	-0.2	0.7
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.5	-0.1	0.7
Number of full sisters	0.2	0.2	0.3	-0.6	-0.3
Qualifications: nursing, teaching	0.2	0.3	0.7	0.8	-0.1
Eye problems/disorders: Cataract	0.2	0.2	0.4	-0.6	0.1
Medication: Gliclazide	0.2	0.2	0.3	-0.3	0.5
Smoking status: Current	0.2	0.3	0.5	-0.7	0.4
Fractured/broken bones in last 5 years	0.2	0.2	0.3	0.5	0.5
Myopia	0.2	0.4	0.7	-0.8	-0.0
Pain experienced in last month	0.2	0.3	0.4	0.2	0.7
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.3	-0.6	0.1
Irritable Bowel Disease (IBD)	0.1	0.2	0.3	0.6	-0.2
Reaction Time	0.1	0.1	0.1	0.4	0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.3	-0.5	0.2
Crohns Disease (2012)	0.1	0.1	0.2	0.4	-0.1
Height	0.1	1.4	1.5	1.1	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.3	-0.4	0.6
Medication: Atenolol	0.1	0.2	0.3	-0.5	-0.3
Sitting height	0.1	0.5	1.0	1.0	-0.2
Hearing difficulty/problems with background noise	0.1	0.2	0.4	-0.6	0.0
Allergy	0.1	0.2	0.2	0.4	-0.5
Fluid intelligence score	0.1	0.2	0.3	0.1	-0.6
Father’s age at death	0.1	0.1	0.3	-0.1	-0.5
Happiness	0.1	0.1	0.2	0.0	0.4
Standing height	0.1	0.8	1.5	0.4	1.2
Medication: Omeprazole	0.1	0.1	0.2	-0.1	-0.5
Comparative height size at age 10	0.1	0.4	0.5	0.7	-0.5
Family relationship satisfaction	0.1	0.1	0.2	-0.1	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.4	0.3
Friendships satisfaction	0.1	0.1	0.1	-0.4	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.3	-0.2	0.5
Financial situation satisfaction	0.1	0.2	0.3	-0.5	-0.2
High cholesterol (Self-reported)	0.1	0.1	0.3	0.1	0.5
Crohns Disease (2017)	0.0	0.0	0.0	-0.1	0.2
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.1	-0.0
Fasting Glucose	0.0	0.1	0.1	0.0	0.3
Blood Eosinophil Count	0.0	0.3	0.5	-0.7	0.3
Blood Platelet Count	0.0	0.0	0.0	-0.1	-0.1
Blood White Count	0.0	0.1	0.1	0.0	-0.4
Waist Hip Ratio (WHR)	0.0	0.2	0.4	-0.2	-0.6
Hair Pigment	0.0	0.5	0.6	-0.8	-0.7
Tanning	0.0	0.1	0.2	0.2	-0.4
Hearing difficulty/problems: Yes	0.0	0.0	0.1	-0.2	-0.2
Medication for hormone replacement therapy	0.0	0.0	0.0	0.1	-0.0
Relative age voice broke	0.0	0.1	0.1	0.1	-0.4
Serious illness, injury or assault to yourself	0.0	0.1	0.1	0.1	-0.3
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	0.4	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.1	0.1	0.4
Hair/balding pattern: Pattern 3	0.0	0.1	0.1	0.3	-0.2
Length of working week for main job	0.0	0.1	0.1	0.2	0.3
Medication: Seretide 50 evohaler	0.0	0.0	0.0	-0.2	0.1
Mean time to correctly identify matches	0.0	0.0	0.1	-0.1	0.2
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.1	0.1	-0.2

Hub : Genes

PAX5

Models

Trait associations