Hub : Traits :

Hearing difficulty/problems: Yes

27 significantly associated models · 18 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 42753863 44149442 1 1 6.9e-08 1.7e-05 1.8e-01 90 ZFP36L2
2 5 72148496 73934274 4 2 2.9e-16 1.4e-19 8.5e-11 49 ANKRA2 ARHGEF28
3 5 147825590 149338157 1 1 6.0e-08 2.1e-07 1.0e+00 100 ABLIM3
4 6 42611872 44034691 1 1 5.4e-13 1.3e-14 6.7e-03 88 ZNF318
5 8 140969818 142706843 1 1 7.3e-08 6.4e-08 1.6e-02 80 PTK2
6 10 74740461 76603535 2 1 9.0e-08 5.5e-06 4.6e-01 97 AP3M1
7 11 117732806 119353188 3 1 9.0e-11 3.0e-10 1.0e+00 100 DDX6
8 12 109295508 110704487 1 1 5.4e-08 3.1e-07 1.0e+00 100 MMAB
9 14 74615330 76019755 1 1 3.2e-07 9.3e-05 1.1e-01 83 RP11-316E14.6
10 17 6469505 7863344 1 1 2.9e-07 1.2e-06 1.4e-01 91 CLDN7

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 1.59 1 0 0.0 0.00 1.0e+00 AP3M1
Irritable Bowel Disease (IBD) 1.36 1 0 0.0 0.00 1.0e+00 AP3M1
Reaction Time 2.16 2 0 0.0 0.00 1.0e+00 AP3M1 CLDN7
Breast Cancer 1.11 1 0 0.0 0.00 1.0e+00 CLDN7
Age at First Birth 2.18 2 0 0.0 0.00 1.0e+00 PTK2 RP11-316E14.6
Crohns Disease (2012) 1.08 1 0 0.0 0.00 1.0e+00 AP3M1
HDL Cholesterol 3.21 1 1 3.0 0.00 1.0e+00 MMAB
Schizophrenia 1.48 1 0 0.0 0.00 1.0e+00 ZNF318
Type 2 Diabetes (T2D) 3.15 2 0 0.0 0.00 1.0e+00 CLDN7 ZNF318
Blood Eosinophil Count 1.16 4 1 3.0 0.97 3.0e-02 AP3M1 CLDN7 DDX6 ZFP36L2
Blood Platelet Count 1.50 6 2 6.1 -0.36 4.9e-01 ABLIM3 AP3M1 DDX6 MMAB ZFP36L2 ZNF318
Blood Red Count 0.38 2 0 0.0 0.00 1.0e+00 PTK2 ZFP36L2
Blood White Count 0.82 2 0 0.0 0.00 1.0e+00 DDX6 PTK2
Heel T-Score 1.83 5 3 9.1 -0.29 6.3e-01 ARHGEF28 DDX6 RP11-316E14.6 ZFP36L2 ZNF318
BMI 1.13 2 0 0.0 0.00 1.0e+00 MMAB ZNF318
Height 0.61 4 2 6.1 -0.96 4.3e-02 CLDN7 MMAB RP11-316E14.6 ZNF318
Waist Hip Ratio (WHR) 2.44 5 1 3.0 0.04 9.4e-01 ABLIM3 CLDN7 PTK2 RP11-316E14.6 ZNF318
Systolic Blood Pressure 4.47 4 3 9.1 0.95 5.3e-02 AP3M1 CLDN7 MMAB ZNF318
Smoking Status 1.74 2 0 0.0 0.00 1.0e+00 CLDN7 PTK2
Allergy or Eczema 0.86 1 0 0.0 0.00 1.0e+00 MMAB
Cardiovascular Disease 3.80 4 2 6.1 0.61 3.9e-01 ANKRA2 AP3M1 ZFP36L2 ZNF318
Hypothyroidism (self reported) 2.02 1 0 0.0 0.00 1.0e+00 PTK2
Lung FEV1/FVC ratio 1.67 3 0 0.0 0.00 1.0e+00 ABLIM3 ANKRA2 CLDN7
Lung FVC 2.20 2 1 3.0 0.00 1.0e+00 ABLIM3 CLDN7
Neuroticism 3.27 3 1 3.0 0.00 1.0e+00 DDX6 MMAB ZNF318
Chronotype (morning person) 1.28 2 0 0.0 0.00 1.0e+00 MMAB ZNF318
Hair Pigment 0.11 2 0 0.0 0.00 1.0e+00 ARHGEF28 PTK2
Tanning 0.19 1 0 0.0 0.00 1.0e+00 ZFP36L2
Number of treatments/medications taken 2.42 2 0 0.0 0.00 1.0e+00 ZFP36L2 ZNF318
Sensitivity / hurt feelings 2.99 3 1 3.0 0.00 1.0e+00 DDX6 MMAB PTK2
Frequency of depressed mood in last 2 weeks 2.64 1 0 0.0 0.00 1.0e+00 PTK2
Relative age of first facial hair 0.89 1 0 0.0 0.00 1.0e+00 DDX6
Systolic blood pressure, automated reading 3.14 3 1 3.0 0.00 1.0e+00 AP3M1 CLDN7 ZNF318
Diabetes (father) 1.83 1 0 0.0 0.00 1.0e+00 CLDN7
Impedance of leg (right) 1.94 3 1 3.0 0.00 1.0e+00 MMAB PTK2 ZNF318
Leg fat-free mass (left) 1.13 3 0 0.0 0.00 1.0e+00 DDX6 MMAB PTK2
Trunk fat percentage 1.47 2 0 0.0 0.00 1.0e+00 RP11-316E14.6 ZFP36L2
Townsend deprivation index at recruitment 1.92 1 0 0.0 0.00 1.0e+00 MMAB
Current tobacco smoking 2.08 1 0 0.0 0.00 1.0e+00 CLDN7
Maternal smoking around birth 2.12 2 0 0.0 0.00 1.0e+00 CLDN7 MMAB
Fed-up feelings 3.30 2 0 0.0 0.00 1.0e+00 CLDN7 PTK2
Taking other prescription medications 2.46 1 0 0.0 0.00 1.0e+00 ZNF318
Age when periods started (menarche) 1.18 1 0 0.0 0.00 1.0e+00 MMAB
High blood pressure 4.40 5 1 3.0 -0.54 3.5e-01 ABLIM3 AP3M1 PTK2 ZFP36L2 ZNF318
Medication: Atenolol 2.62 1 0 0.0 0.00 1.0e+00 ZFP36L2
Sitting height 0.76 3 0 0.0 0.00 1.0e+00 DDX6 PTK2 ZNF318
Chronic bronchitis/emphysema (father) 1.84 1 0 0.0 0.00 1.0e+00 PTK2
High blood pressure (mother) 3.39 2 0 0.0 0.00 1.0e+00 AP3M1 ZNF318
Body mass index (BMI) 0.91 1 0 0.0 0.00 1.0e+00 MMAB
Impedance of leg (left) 2.02 3 2 6.1 0.00 1.0e+00 MMAB PTK2 ZNF318
Leg predicted mass (left) 1.11 3 0 0.0 0.00 1.0e+00 DDX6 MMAB PTK2
Trunk fat mass 1.21 2 0 0.0 0.00 1.0e+00 RP11-316E14.6 ZFP36L2
Waist circumference 1.35 2 0 0.0 0.00 1.0e+00 CLDN7 RP11-316E14.6
Nervous feelings 1.42 1 0 0.0 0.00 1.0e+00 MMAB
Frequency of tenseness / restlessness in last 2 weeks 2.77 1 1 3.0 0.00 1.0e+00 MMAB
Hearing difficulty/problems with background noise 13.56 9 3 9.1 0.98 3.2e-06 ABLIM3 ANKRA2 AP3M1 ARHGEF28 DDX6 MMAB PTK2 ZFP36L2 ZNF318
Forced vital capacity (FVC) 2.39 4 2 6.1 -0.62 3.8e-01 ABLIM3 ANKRA2 CLDN7 DDX6
Qualifications: None of the above 1.52 1 0 0.0 0.00 1.0e+00 PTK2
Mouth/teeth dental problems 2.72 2 0 0.0 0.00 1.0e+00 MMAB PTK2
Allergy 1.49 1 0 0.0 0.00 1.0e+00 MMAB
Neuroticism score 3.16 4 0 0.0 0.49 5.1e-01 DDX6 MMAB ZFP36L2 ZNF318
Weight 0.99 3 0 0.0 0.00 1.0e+00 DDX6 MMAB RP11-316E14.6
Impedance of arm (right) 0.98 3 0 0.0 0.00 1.0e+00 PTK2 RP11-316E14.6 ZNF318
Arm fat percentage (right) 1.33 3 0 0.0 0.00 1.0e+00 CLDN7 RP11-316E14.6 ZFP36L2
Trunk fat-free mass 1.00 3 1 3.0 0.00 1.0e+00 DDX6 MMAB PTK2
Hip circumference 1.25 3 0 0.0 0.00 1.0e+00 ABLIM3 MMAB RP11-316E14.6
Father's age at death 1.94 1 0 0.0 0.00 1.0e+00 ZFP36L2
Worrier / anxious feelings 1.63 2 0 0.0 0.00 1.0e+00 MMAB ZNF318
Frequency of tiredness / lethargy in last 2 weeks 4.10 2 1 3.0 0.00 1.0e+00 MMAB ZFP36L2
Falls in the last year 2.95 2 0 0.0 0.00 1.0e+00 MMAB PTK2
Forced expiratory volume in 1-second (FEV1) 1.88 3 1 3.0 0.00 1.0e+00 ABLIM3 CLDN7 DDX6
Mouth/teeth dental problems: Dentures 2.09 2 0 0.0 0.00 1.0e+00 ARHGEF28 PTK2
Forced expiratory volume in 1-second (FEV1), Best measure 1.75 1 0 0.0 0.00 1.0e+00 ABLIM3
Impedance of arm (left) 0.88 1 0 0.0 0.00 1.0e+00 PTK2
Arm fat mass (right) 1.15 2 0 0.0 0.00 1.0e+00 MMAB RP11-316E14.6
Trunk predicted mass 0.99 3 1 3.0 0.00 1.0e+00 DDX6 MMAB PTK2
Standing height 1.00 3 2 6.1 0.00 1.0e+00 DDX6 RP11-316E14.6 ZNF318
Tense / 'highly strung' 2.04 1 0 0.0 0.00 1.0e+00 DDX6
Birth weight of first child 3.22 1 1 3.0 0.00 1.0e+00 PTK2
Peak expiratory flow (PEF) 1.86 3 0 0.0 0.00 1.0e+00 ABLIM3 CLDN7 MMAB
Mouth/teeth dental problems: Bleeding gums 2.35 1 0 0.0 0.00 1.0e+00 MMAB
Medication: Paracetamol 3.78 3 1 3.0 0.00 1.0e+00 MMAB PTK2 ZFP36L2
Gout (self-reported) 1.83 1 0 0.0 0.00 1.0e+00 ZNF318
Hypothyroidism/myxoedema (self-reported) 2.11 2 0 0.0 0.00 1.0e+00 DDX6 PTK2
Medication: Amlodipine 2.95 2 0 0.0 0.00 1.0e+00 AP3M1 ZNF318
Birth weight 4.86 2 1 3.0 0.00 1.0e+00 CLDN7 PTK2
Forced vital capacity (FVC), Best measure 2.22 4 0 0.0 -0.61 3.9e-01 ABLIM3 ANKRA2 CLDN7 DDX6
Body fat percentage 1.47 2 0 0.0 0.00 1.0e+00 RP11-316E14.6 ZFP36L2
Leg fat percentage (right) 1.54 3 1 3.0 0.00 1.0e+00 CLDN7 RP11-316E14.6 ZFP36L2
Arm fat-free mass (right) 0.81 1 0 0.0 0.00 1.0e+00 DDX6
Comparative body size at age 10 1.32 1 0 0.0 0.00 1.0e+00 ZNF318
Number of full brothers 2.12 1 0 0.0 0.00 1.0e+00 PTK2
Worry too long after embarrassment 2.01 1 0 0.0 0.00 1.0e+00 MMAB
Wheeze or whistling in the chest in last year 1.87 1 0 0.0 0.00 1.0e+00 ZNF318
Age at first live birth 1.56 1 0 0.0 0.00 1.0e+00 PTK2
Qualifications: College or University degree 2.00 1 1 3.0 0.00 1.0e+00 PTK2
Mouth/teeth dental problems: Loose teeth 1.09 1 0 0.0 0.00 1.0e+00 PTK2
Medication for pain relief, constipation, heartburn 2.83 2 0 0.0 0.00 1.0e+00 PTK2 ZFP36L2
Neck or shoulder pain in last month 2.95 1 0 0.0 0.00 1.0e+00 PTK2
Medication: Blood pressure 2.30 1 0 0.0 0.00 1.0e+00 CLDN7
Mean time to correctly identify matches 1.94 2 0 0.0 0.00 1.0e+00 AP3M1 CLDN7
Whole body fat mass 1.24 2 0 0.0 0.00 1.0e+00 RP11-316E14.6 ZFP36L2
Leg fat mass (right) 1.16 2 0 0.0 0.00 1.0e+00 RP11-316E14.6 ZFP36L2
Arm predicted mass (right) 0.85 1 0 0.0 0.00 1.0e+00 DDX6
Pulse rate, automated reading 1.00 1 0 0.0 0.00 1.0e+00 MMAB
Alcohol intake frequency. 1.43 2 0 0.0 0.00 1.0e+00 RP11-316E14.6 ZNF318
Comparative height size at age 10 0.66 1 0 0.0 0.00 1.0e+00 RP11-316E14.6
Number of full sisters 1.91 1 0 0.0 0.00 1.0e+00 AP3M1
Overall health rating 2.14 2 0 0.0 0.00 1.0e+00 PTK2 ZFP36L2
Chest pain or discomfort 1.77 1 0 0.0 0.00 1.0e+00 CLDN7
Medication: Aspirin 2.21 1 0 0.0 0.00 1.0e+00 ZFP36L2
Knee pain experienced in last month 3.19 2 0 0.0 0.00 1.0e+00 AP3M1 PTK2
Hypertension (Self-reported) 4.12 4 1 3.0 -0.65 3.5e-01 AP3M1 PTK2 ZFP36L2 ZNF318
Illnesses of father: Heart disease 1.73 1 0 0.0 0.00 1.0e+00 ZFP36L2
Whole body fat-free mass 1.00 3 0 0.0 0.00 1.0e+00 DDX6 MMAB PTK2
Leg fat-free mass (right) 1.13 3 0 0.0 0.00 1.0e+00 DDX6 MMAB PTK2
Arm fat percentage (left) 1.26 1 0 0.0 0.00 1.0e+00 ZFP36L2
Mood swings 3.72 2 1 3.0 0.00 1.0e+00 MMAB PTK2
Loneliness, isolation 2.13 1 0 0.0 0.00 1.0e+00 DDX6
Long-standing illness, disability or infirmity 2.15 1 0 0.0 0.00 1.0e+00 MMAB
Friendships satisfaction 1.73 1 0 0.0 0.00 1.0e+00 ABLIM3
Medication for cholesterol 2.20 1 0 0.0 0.00 1.0e+00 ZNF318
Back pain experienced in last month 2.51 1 0 0.0 0.00 1.0e+00 PTK2
Mineral and other dietary supplements 1.33 1 0 0.0 0.00 1.0e+00 AP3M1
Osteoarthritis (self-reported) 1.86 1 0 0.0 0.00 1.0e+00 PTK2
Medication: Aspirin 2.26 1 0 0.0 0.00 1.0e+00 ZFP36L2
Illnesses of father: None of the above (group 1) 2.27 1 0 0.0 0.00 1.0e+00 AP3M1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.65 1 0 0.0 0.00 1.0e+00 ABLIM3
Whole body water mass 1.03 3 0 0.0 0.00 1.0e+00 DDX6 MMAB PTK2
Leg predicted mass (right) 1.14 3 0 0.0 0.00 1.0e+00 DDX6 MMAB PTK2
Arm fat mass (left) 1.10 3 0 0.0 0.00 1.0e+00 MMAB RP11-316E14.6 ZFP36L2
Number of self-reported non-cancer illnesses 2.70 2 0 0.0 0.00 1.0e+00 ZFP36L2 ZNF318
Average weekly champagne plus white wine intake 2.42 2 0 0.0 0.00 1.0e+00 ANKRA2 DDX6
Miserableness 2.41 1 0 0.0 0.00 1.0e+00 MMAB
Hearing aid user 7.62 5 0 0.0 0.99 2.0e-03 ANKRA2 ARHGEF28 DDX6 PTK2 ZFP36L2
Financial situation satisfaction 2.23 2 0 0.0 0.00 1.0e+00 MMAB PTK2
Tinnitus: Yes, now most or all of the time 4.10 1 0 0.0 0.00 1.0e+00 ZNF318
Commuting to job workplace: Public transport 1.73 1 0 0.0 0.00 1.0e+00 DDX6
Medication: Blood pressure 4.74 3 1 3.0 0.00 1.0e+00 AP3M1 ZFP36L2 ZNF318
Medication: Bendroflumethiazide 2.75 1 0 0.0 0.00 1.0e+00 ZNF318
Medication: Paracetamol 3.36 2 0 0.0 0.00 1.0e+00 PTK2 ZFP36L2
Illnesses of father: High blood pressure 2.59 1 0 0.0 0.00 1.0e+00 AP3M1
Basal metabolic rate 0.97 2 0 0.0 0.00 1.0e+00 DDX6 MMAB
Leg fat percentage (left) 1.41 2 0 0.0 0.00 1.0e+00 CLDN7 ZFP36L2
Arm fat-free mass (left) 0.89 1 0 0.0 0.00 1.0e+00 DDX6
Irritability 2.85 3 0 0.0 0.00 1.0e+00 CLDN7 MMAB ZFP36L2
Vascular/heart problems diagnosed by doctor 4.40 4 1 3.0 0.62 3.8e-01 AP3M1 PTK2 ZFP36L2 ZNF318
Cholesterol lowering medication 1.80 1 0 0.0 0.00 1.0e+00 ZNF318
Pain experienced in last month 3.59 3 0 0.0 0.00 1.0e+00 MMAB PTK2 ZFP36L2
Alcohol drinker status: Previous 2.13 1 0 0.0 0.00 1.0e+00 PTK2
Impedance of whole body 1.41 3 1 3.0 0.00 1.0e+00 MMAB PTK2 ZNF318
Leg fat mass (left) 1.07 2 0 0.0 0.00 1.0e+00 RP11-316E14.6 ZFP36L2
Arm predicted mass (left) 0.88 1 1 3.0 0.00 1.0e+00 DDX6

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.0573 1.60
GTEx Adipose Visceral Omentum 1 0.0491 1.55
GTEx Adrenal Gland 0 0.0000 1.64
GTEx Artery Aorta 0 0.0000 1.53
GTEx Artery Coronary 0 0.0000 1.57
GTEx Artery Tibial 2 0.0532 1.54
GTEx Brain Caudate basal ganglia 1 0.1087 1.51
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.50
GTEx Brain Cerebellum 1 0.0505 1.60
GTEx Brain Cortex 1 0.0966 1.55
GTEx Brain Frontal Cortex BA9 0 0.0000 1.59
GTEx Brain Hippocampus 0 0.0000 1.42
GTEx Brain Hypothalamus 0 0.0000 1.38
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.46
GTEx Brain Putamen basal ganglia 0 0.0000 1.49
GTEx Breast Mammary Tissue 1 0.0507 1.62
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.53
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.47
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.60
GTEx Cells Transformed fibroblasts 1 0.0238 1.53
GTEx Colon Sigmoid 0 0.0000 1.61
GTEx Colon Transverse 0 0.0000 1.58
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.54
GTEx Esophagus Mucosa 2 0.0602 1.57
GTEx Esophagus Muscularis 0 0.0000 1.56
GTEx Heart Atrial Appendage 0 0.0000 1.52
GTEx Heart Left Ventricle 0 0.0000 1.57
GTEx Liver 1 0.1395 1.49
GTEx Lung 0 0.0000 1.56
GTEx Muscle Skeletal 0 0.0000 1.57
GTEx Nerve Tibial 1 0.0231 1.57
GTEx Ovary 0 0.0000 1.54
GTEx Pancreas 2 0.1225 1.58
GTEx Pituitary 0 0.0000 1.63
GTEx Prostate 0 0.0000 1.54
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.56
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.57
GTEx Small Intestine Terminal Ileum 0 0.0000 1.53
GTEx Spleen 0 0.0000 1.56
GTEx Stomach 0 0.0000 1.55
GTEx Testis 0 0.0000 1.57
GTEx Thyroid 0 0.0000 1.67
GTEx Uterus 0 0.0000 1.65
GTEx Vagina 0 0.0000 1.41
GTEx Whole Blood 1 0.0502 1.64
METSIM Adipose 1 0.0217 1.50
NTR Blood 1 0.0416 1.45
ROSMAP Brain Pre-frontal Cortex 2 0.0455 1.59
YFS Blood 1 0.0217 1.48
CommonMind Brain Pre-frontal Cortex 2 0.0372 1.47
TCGA Breast Tumor 1 0.1304 1.57
TCGA Breast Normal 1 0.0238 1.41
TCGA Ovarian Tumor 0 0.0000 1.40
TCGA Prostate Tumor 1 0.0289 1.56