Hub : Traits :

Angina

32 significantly associated models · 13 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 109098737 110517617 2 1 4.0e-12 3.3e-12 1.0e+00 100 PSRC1
2 1 222133118 223529093 1 1 7.2e-08 7.8e-07 5.9e-01 99 RP11-378J18.8
3 6 12020241 13990267 2 1 2.3e-08 2.5e-08 1.0e+00 100 RP1-257A7.5
4 6 160071844 161571560 1 1 9.0e-08 5.2e-16 1.9e-14 11 SLC22A3
5 9 21303958 22819407 2 2 2.2e-22 1.2e-34 1.6e-14 61 CDKN2B CDKN2B-AS1
6 15 77888924 79802863 2 2 9.8e-11 5.7e-10 2.7e-01 97 ADAMTS7
7 15 90718541 92135418 2 1 4.7e-10 1.4e-08 8.2e-01 100 FES
8 20 62018747 62912463 1 1 3.2e-07 9.7e-07 6.0e-01 99 C20orf201

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (in mother) 1.33 1 0 0.0 0.00 1.0e+00 ADAMTS7
Crohns Disease (2017) 1.03 1 0 0.0 0.00 1.0e+00 FES
Irritable Bowel Disease (IBD) 1.00 1 0 0.0 0.00 1.0e+00 FES
Ulcerative Colitis (UC) 1.31 1 0 0.0 0.00 1.0e+00 C20orf201
Major Depression (MDD) 2.91 1 0 0.0 0.00 1.0e+00 FES
Breast Cancer 2.99 3 0 0.0 0.00 1.0e+00 CDKN2B CDKN2B-AS1 FES
Coronary Artery Disease (CAD) 29.17 7 5 15.2 -0.98 8.6e-06 ADAMTS7 CDKN2B CDKN2B-AS1 FES PSRC1 RP1-257A7.5 SLC22A3
HDL Cholesterol 2.49 1 1 3.0 0.00 1.0e+00 PSRC1
LDL Cholesterol 56.74 1 1 3.0 0.00 1.0e+00 PSRC1
Rheumatoid Arthritis 2.29 1 0 0.0 0.00 1.0e+00 C20orf201
Schizophrenia 2.74 1 1 3.0 0.00 1.0e+00 FES
Type 2 Diabetes (T2D) 3.98 1 0 0.0 0.00 1.0e+00 CDKN2B
Blood Eosinophil Count 0.42 1 0 0.0 0.00 1.0e+00 C20orf201
Blood Platelet Count 0.85 3 1 3.0 -0.97 3.2e-02 ADAMTS7 CDKN2B SLC22A3
Blood Red Count 0.52 2 0 0.0 0.00 1.0e+00 FES RP1-257A7.5
Blood White Count 1.58 3 1 3.0 0.00 1.0e+00 C20orf201 CDKN2B FES
Heel T-Score 0.42 1 0 0.0 0.00 1.0e+00 PSRC1
BMI 0.99 1 0 0.0 0.00 1.0e+00 SLC22A3
Height 0.75 3 3 9.1 0.00 1.0e+00 FES PSRC1 SLC22A3
Waist Hip Ratio (WHR) 3.09 3 2 6.1 0.00 1.0e+00 ADAMTS7 C20orf201 SLC22A3
Systolic Blood Pressure 8.31 5 3 9.1 -0.59 2.9e-01 ADAMTS7 C20orf201 FES RP1-257A7.5 SLC22A3
Smoking Status 1.98 2 0 0.0 0.00 1.0e+00 FES PSRC1
Allergy or Eczema 1.58 1 0 0.0 0.00 1.0e+00 FES
Cardiovascular Disease 10.32 4 3 9.1 -0.98 1.7e-02 C20orf201 FES PSRC1 SLC22A3
Respiratory disease 1.49 1 0 0.0 0.00 1.0e+00 FES
Type 2 Diabetes (T2D) 2.06 1 0 0.0 0.00 1.0e+00 SLC22A3
Lung FEV1/FVC ratio 0.99 2 1 3.0 0.00 1.0e+00 PSRC1 RP11-378J18.8
Lung FVC 1.00 1 1 3.0 0.00 1.0e+00 C20orf201
Neuroticism 0.81 1 0 0.0 0.00 1.0e+00 FES
Hair Pigment 0.58 5 3 9.1 0.80 1.0e-01 ADAMTS7 C20orf201 CDKN2B CDKN2B-AS1 FES
Hand grip strength (left) 2.12 2 1 3.0 0.00 1.0e+00 FES RP1-257A7.5
Number of treatments/medications taken 3.29 2 1 3.0 0.00 1.0e+00 FES PSRC1
Sensitivity / hurt feelings 1.59 1 0 0.0 0.00 1.0e+00 FES
Hearing difficulty/problems: Yes 1.67 1 0 0.0 0.00 1.0e+00 PSRC1
Other serious medical condition/disability diagnosed by doctor 1.05 1 0 0.0 0.00 1.0e+00 PSRC1
Systolic blood pressure, automated reading 6.41 3 1 3.0 0.00 1.0e+00 C20orf201 FES RP1-257A7.5
Vitamin and mineral supplements 1.88 1 0 0.0 0.00 1.0e+00 ADAMTS7
Medication: Metformin 2.06 1 0 0.0 0.00 1.0e+00 CDKN2B
Pack years adult smoking proportion 8.21 1 1 3.0 0.00 1.0e+00 ADAMTS7
Impedance of leg (right) 1.49 2 1 3.0 0.00 1.0e+00 C20orf201 FES
Leg fat-free mass (left) 1.25 4 0 0.0 -0.99 1.3e-02 C20orf201 FES PSRC1 SLC22A3
Trunk fat percentage 1.21 1 0 0.0 0.00 1.0e+00 SLC22A3
Hand grip strength (right) 1.48 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
High blood pressure 6.78 2 1 3.0 0.00 1.0e+00 C20orf201 FES
Hayfever, allergic rhinitis or eczema 1.69 1 0 0.0 0.00 1.0e+00 FES
Multivitamins +/- minerals 2.23 1 0 0.0 0.00 1.0e+00 ADAMTS7
Medication: Atenolol 7.52 2 1 3.0 0.00 1.0e+00 CDKN2B FES
Sitting height 0.83 2 0 0.0 0.00 1.0e+00 ADAMTS7 SLC22A3
Chronic bronchitis/emphysema (father) 4.11 1 0 0.0 0.00 1.0e+00 ADAMTS7
High blood pressure (mother) 6.94 2 1 3.0 0.00 1.0e+00 FES RP1-257A7.5
Impedance of leg (left) 1.42 2 1 3.0 0.00 1.0e+00 C20orf201 FES
Leg predicted mass (left) 1.26 4 0 0.0 -0.99 1.1e-02 C20orf201 FES PSRC1 SLC22A3
Trunk fat mass 1.19 1 0 0.0 0.00 1.0e+00 SLC22A3
Number of incorrect matches in round 1.23 1 0 0.0 0.00 1.0e+00 FES
Past tobacco smoking 2.07 1 0 0.0 0.00 1.0e+00 CDKN2B-AS1
Alcohol usually taken with meals 1.92 1 0 0.0 0.00 1.0e+00 FES
Forced vital capacity (FVC) 0.95 1 0 0.0 0.00 1.0e+00 C20orf201
Heart attack 26.19 8 7 21.2 0.98 3.2e-05 ADAMTS7 CDKN2B CDKN2B-AS1 FES PSRC1 RP11-378J18.8 RP1-257A7.5 SLC22A3
Allergy 1.64 1 0 0.0 0.00 1.0e+00 FES
Medication: Ramipril 4.78 2 0 0.0 0.00 1.0e+00 FES SLC22A3
Medication: Simvastatin 18.62 7 3 9.1 0.90 6.2e-03 C20orf201 CDKN2B CDKN2B-AS1 FES PSRC1 RP11-378J18.8 SLC22A3
Illnesses of siblings 3.42 1 0 0.0 0.00 1.0e+00 FES
Weight 1.05 1 0 0.0 0.00 1.0e+00 SLC22A3
Impedance of arm (right) 0.99 2 0 0.0 0.00 1.0e+00 C20orf201 CDKN2B
Arm fat percentage (right) 1.18 1 0 0.0 0.00 1.0e+00 SLC22A3
Trunk fat-free mass 1.24 3 1 3.0 0.00 1.0e+00 C20orf201 PSRC1 SLC22A3
Hip circumference 1.50 2 1 3.0 0.00 1.0e+00 ADAMTS7 SLC22A3
Father's age at death 7.18 4 1 3.0 -1.00 4.2e-03 CDKN2B CDKN2B-AS1 FES PSRC1
Number of live births 1.14 1 0 0.0 0.00 1.0e+00 FES
Forced expiratory volume in 1-second (FEV1) 0.86 1 0 0.0 0.00 1.0e+00 C20orf201
Asthma 1.08 1 0 0.0 0.00 1.0e+00 FES
Medication: Ibuprofen (e.g. Nurofen) 4.50 2 1 3.0 0.00 1.0e+00 RP1-257A7.5 SLC22A3
Medication: Cholesterol lowering 25.70 7 3 9.1 0.89 6.6e-03 C20orf201 CDKN2B CDKN2B-AS1 FES PSRC1 RP11-378J18.8 SLC22A3
Lung cancer (father) 5.67 1 0 0.0 0.00 1.0e+00 ADAMTS7
Illnesses of mother 5.08 2 1 3.0 0.00 1.0e+00 CDKN2B FES
Pulse wave Arterial Stiffness index 4.12 2 0 0.0 0.00 1.0e+00 FES RP1-257A7.5
Impedance of arm (left) 0.90 1 0 0.0 0.00 1.0e+00 C20orf201
Arm fat mass (right) 1.08 1 0 0.0 0.00 1.0e+00 SLC22A3
Trunk predicted mass 1.22 3 1 3.0 0.00 1.0e+00 C20orf201 PSRC1 SLC22A3
Standing height 0.70 2 1 3.0 0.00 1.0e+00 PSRC1 SLC22A3
Breastfed as a baby 1.45 1 0 0.0 0.00 1.0e+00 FES
Hair/balding pattern: Pattern 4 1.22 1 0 0.0 0.00 1.0e+00 FES
Birth weight of first child 4.04 2 1 3.0 0.00 1.0e+00 C20orf201 FES
Medication: Paracetamol 2.56 1 1 3.0 0.00 1.0e+00 RP1-257A7.5
Headache pain in last month 4.76 2 1 3.0 0.00 1.0e+00 FES RP1-257A7.5
Medication for cholesterol, blood pressure or diabetes 12.63 4 3 9.1 -0.96 3.9e-02 C20orf201 FES PSRC1 RP11-378J18.8
Glaucoma (self-reported) 6.80 2 1 3.0 0.00 1.0e+00 CDKN2B CDKN2B-AS1
Medication: Amlodipine 3.17 1 1 3.0 0.00 1.0e+00 FES
Birth weight 2.50 1 1 3.0 0.00 1.0e+00 FES
Chronic bronchitis/emphysema (mother) 2.91 1 0 0.0 0.00 1.0e+00 ADAMTS7
High blood pressure (siblings) 3.40 1 1 3.0 0.00 1.0e+00 FES
Body fat percentage 1.16 1 0 0.0 0.00 1.0e+00 SLC22A3
Leg fat percentage (right) 1.09 1 0 0.0 0.00 1.0e+00 RP11-378J18.8
Arm fat-free mass (right) 1.06 3 0 0.0 0.00 1.0e+00 C20orf201 PSRC1 SLC22A3
Pulse wave peak to peak time 4.08 2 0 0.0 0.00 1.0e+00 FES RP1-257A7.5
Medication for pain relief, constipation, heartburn 2.73 2 0 0.0 0.00 1.0e+00 PSRC1 RP1-257A7.5
Medication: Blood pressure 6.17 2 1 3.0 0.00 1.0e+00 C20orf201 FES
Angina (self-reported) 35.68 9 9 27.3 1.00 3.1e-14 ADAMTS7 C20orf201 CDKN2B CDKN2B-AS1 FES PSRC1 RP11-378J18.8 RP1-257A7.5 SLC22A3
Migraine (self-reported) 5.85 1 1 3.0 0.00 1.0e+00 RP1-257A7.5
Medication: Ibuprofen 4.59 2 1 3.0 0.00 1.0e+00 RP1-257A7.5 SLC22A3
Mean time to correctly identify matches 1.36 1 0 0.0 0.00 1.0e+00 FES
Heart disease (mother) 15.83 7 3 9.1 0.97 6.0e-05 ADAMTS7 CDKN2B CDKN2B-AS1 FES RP11-378J18.8 RP1-257A7.5 SLC22A3
Whole body fat mass 1.16 1 0 0.0 0.00 1.0e+00 SLC22A3
Leg fat mass (right) 0.95 1 0 0.0 0.00 1.0e+00 SLC22A3
Arm predicted mass (right) 1.06 3 0 0.0 0.00 1.0e+00 C20orf201 PSRC1 SLC22A3
Pulse rate, automated reading 1.69 2 0 0.0 0.00 1.0e+00 RP11-378J18.8 RP1-257A7.5
Alcohol intake frequency. 2.03 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Comparative height size at age 10 1.02 3 0 0.0 0.00 1.0e+00 FES PSRC1 SLC22A3
Chest pain or discomfort 3.38 1 0 0.0 0.00 1.0e+00 CDKN2B
Had major operations 2.07 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Medication: Aspirin 16.87 6 5 15.2 0.98 4.2e-04 C20orf201 CDKN2B CDKN2B-AS1 FES PSRC1 SLC22A3
Hypertension (Self-reported) 6.99 3 1 3.0 0.00 1.0e+00 C20orf201 FES SLC22A3
Illnesses of father: Heart disease 31.11 9 7 21.2 0.99 1.3e-07 ADAMTS7 C20orf201 CDKN2B CDKN2B-AS1 FES PSRC1 RP11-378J18.8 RP1-257A7.5 SLC22A3
Smoking status: Previous 1.87 1 0 0.0 0.00 1.0e+00 CDKN2B-AS1
Whole body fat-free mass 1.22 4 0 0.0 -1.00 3.5e-03 C20orf201 FES PSRC1 SLC22A3
Leg fat-free mass (right) 1.27 4 0 0.0 -0.99 8.6e-03 C20orf201 FES PSRC1 SLC22A3
Handedness (chirality/laterality): Left-handed 2.09 1 0 0.0 0.00 1.0e+00 FES
Long-standing illness, disability or infirmity 1.91 1 0 0.0 0.00 1.0e+00 CDKN2B
Diabetes diagnosed by doctor 2.15 1 0 0.0 0.00 1.0e+00 SLC22A3
Medication for cholesterol 7.00 4 2 6.1 -0.99 1.2e-02 C20orf201 FES PSRC1 SLC22A3
Breast cancer (self-reported) 3.10 1 0 0.0 0.00 1.0e+00 CDKN2B
Asthma (self-reported) 1.09 1 0 0.0 0.00 1.0e+00 FES
Medication: Aspirin 16.63 6 5 15.2 0.98 4.1e-04 C20orf201 CDKN2B CDKN2B-AS1 FES PSRC1 SLC22A3
Illnesses of father: None of the above (group 1) 10.97 4 2 6.1 -0.98 2.0e-02 CDKN2B CDKN2B-AS1 FES SLC22A3
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.52 2 0 0.0 0.00 1.0e+00 ADAMTS7 C20orf201
Whole body water mass 1.20 4 0 0.0 -1.00 2.0e-03 C20orf201 FES PSRC1 SLC22A3
Leg predicted mass (right) 1.28 3 0 0.0 0.00 1.0e+00 FES PSRC1 SLC22A3
Arm fat mass (left) 1.06 1 0 0.0 0.00 1.0e+00 SLC22A3
Number of self-reported non-cancer illnesses 3.49 2 0 0.0 0.00 1.0e+00 C20orf201 PSRC1
Eye problems/disorders: Glaucoma 8.95 2 2 6.1 0.00 1.0e+00 CDKN2B CDKN2B-AS1
Medication: Blood pressure 6.74 4 1 3.0 0.75 2.5e-01 ADAMTS7 C20orf201 FES SLC22A3
Supplements: Fish oil (including cod liver oil) 2.25 1 0 0.0 0.00 1.0e+00 SLC22A3
High cholesterol (Self-reported) 28.37 5 3 9.1 0.85 6.7e-02 C20orf201 FES PSRC1 RP11-378J18.8 SLC22A3
Medication: Bendroflumethiazide 4.32 3 1 3.0 0.00 1.0e+00 ADAMTS7 FES RP1-257A7.5
Medication: Paracetamol 2.36 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Medication: Lisinopril 2.16 1 0 0.0 0.00 1.0e+00 FES
Medication: Atorvastatin 18.41 5 2 6.1 0.96 9.4e-03 C20orf201 CDKN2B CDKN2B-AS1 PSRC1 SLC22A3
Illnesses of father: High blood pressure 4.42 1 1 3.0 0.00 1.0e+00 FES
Ever smoked 1.46 1 0 0.0 0.00 1.0e+00 FES
Basal metabolic rate 1.17 4 0 0.0 -0.99 5.8e-03 C20orf201 FES PSRC1 SLC22A3
Arm fat-free mass (left) 0.99 3 0 0.0 0.00 1.0e+00 C20orf201 PSRC1 SLC22A3
Risk taking 2.21 1 0 0.0 0.00 1.0e+00 FES
Age started oral contraceptive pill 1.21 1 0 0.0 0.00 1.0e+00 FES
Diastolic blood pressure, automated reading 6.99 4 2 6.1 -0.15 8.1e-01 ADAMTS7 CDKN2B CDKN2B-AS1 FES
Vascular/heart problems diagnosed by doctor 8.51 4 2 6.1 -0.91 8.9e-02 C20orf201 CDKN2B FES SLC22A3
Cholesterol lowering medication 16.10 4 3 9.1 0.90 9.8e-02 C20orf201 CDKN2B PSRC1 SLC22A3
Pain experienced in last month 1.71 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Basal cell carcinoma (self-reported) 3.51 1 0 0.0 0.00 1.0e+00 CDKN2B
Heart attack/myocardial infarction (self-reported) 26.58 8 7 21.2 0.97 3.9e-05 ADAMTS7 CDKN2B CDKN2B-AS1 FES PSRC1 RP11-378J18.8 RP1-257A7.5 SLC22A3
Heart disease (siblings) 11.95 7 1 3.0 0.95 1.1e-03 ADAMTS7 CDKN2B CDKN2B-AS1 FES PSRC1 RP1-257A7.5 SLC22A3
Pack years of smoking 7.29 1 1 3.0 0.00 1.0e+00 ADAMTS7
Impedance of whole body 1.17 2 1 3.0 0.00 1.0e+00 C20orf201 PSRC1
Leg fat mass (left) 0.84 1 0 0.0 0.00 1.0e+00 SLC22A3
Arm predicted mass (left) 1.09 3 0 0.0 0.00 1.0e+00 C20orf201 PSRC1 SLC22A3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.32
GTEx Adipose Visceral Omentum 1 0.0491 1.29
GTEx Adrenal Gland 0 0.0000 1.34
GTEx Artery Aorta 2 0.0672 1.39
GTEx Artery Coronary 0 0.0000 1.31
GTEx Artery Tibial 3 0.0798 1.38
GTEx Brain Caudate basal ganglia 0 0.0000 1.27
GTEx Brain Cerebellar Hemisphere 1 0.0672 1.30
GTEx Brain Cerebellum 0 0.0000 1.33
GTEx Brain Cortex 0 0.0000 1.38
GTEx Brain Frontal Cortex BA9 0 0.0000 1.37
GTEx Brain Hippocampus 0 0.0000 1.32
GTEx Brain Hypothalamus 0 0.0000 1.17
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.29
GTEx Brain Putamen basal ganglia 1 0.1603 1.24
GTEx Breast Mammary Tissue 0 0.0000 1.31
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.20
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.24
GTEx Cells EBV-transformed lymphocytes 1 0.0703 1.35
GTEx Cells Transformed fibroblasts 1 0.0238 1.32
GTEx Colon Sigmoid 0 0.0000 1.23
GTEx Colon Transverse 0 0.0000 1.34
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.27
GTEx Esophagus Mucosa 1 0.0301 1.30
GTEx Esophagus Muscularis 0 0.0000 1.33
GTEx Heart Atrial Appendage 0 0.0000 1.29
GTEx Heart Left Ventricle 0 0.0000 1.29
GTEx Liver 1 0.1395 1.41
GTEx Lung 1 0.0348 1.32
GTEx Muscle Skeletal 1 0.0346 1.33
GTEx Nerve Tibial 0 0.0000 1.30
GTEx Ovary 0 0.0000 1.32
GTEx Pancreas 0 0.0000 1.34
GTEx Pituitary 0 0.0000 1.29
GTEx Prostate 0 0.0000 1.25
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.30
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.36
GTEx Small Intestine Terminal Ileum 0 0.0000 1.39
GTEx Spleen 0 0.0000 1.31
GTEx Stomach 0 0.0000 1.33
GTEx Testis 0 0.0000 1.27
GTEx Thyroid 1 0.0250 1.34
GTEx Uterus 0 0.0000 1.29
GTEx Vagina 0 0.0000 1.39
GTEx Whole Blood 1 0.0502 1.29
METSIM Adipose 1 0.0217 1.27
NTR Blood 0 0.0000 1.26
ROSMAP Brain Pre-frontal Cortex 3 0.0683 1.32
YFS Blood 2 0.0433 1.28
CommonMind Brain Pre-frontal Cortex 5 0.0930 1.35
TCGA Breast Tumor 0 0.0000 1.29
TCGA Breast Normal 1 0.0238 1.21
TCGA Ovarian Tumor 2 0.0684 1.23
TCGA Prostate Tumor 1 0.0289 1.28