Hub : Traits :

Alcohol intake versus 10 years previously

103 significantly associated models · 22 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 752566 1907912 3 1 1.4e-08 4.2e-08 1.00000 100 C1orf170
2 1 39328203 40737589 1 1 3.0e-07 3.1e-06 0.16100 91 PABPC4
3 1 43699813 45157738 3 1 2.2e-08 4.9e-08 0.02010 82 DPH2
4 2 26883355 28364426 2 1 3.2e-08 4.7e-11 0.00036 71 AC074117.10
5 3 49016056 51043528 10 1 4.2e-10 6.3e-09 0.04930 88 RNF123
6 5 78582833 79974983 1 1 3.7e-07 9.5e-07 0.08450 88 MTX3
7 6 89108830 90520848 1 1 2.9e-07 2.7e-06 0.58800 99 SRSF12
8 10 130935586 132459060 1 1 4.0e-07 3.4e-06 0.00422 62 EBF3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 5.90 2 2 6.1 0.00 1.000 AC074117.10 RNF123
Irritable Bowel Disease (IBD) 5.68 2 2 6.1 0.00 1.000 AC074117.10 RNF123
Ulcerative Colitis (UC) 3.11 1 1 3.0 0.00 1.000 RNF123
Reaction Time 2.13 1 0 0.0 0.00 1.000 RNF123
Verbal and Numeric Reasoning (VNR) 5.23 2 1 3.0 0.00 1.000 DPH2 RNF123
Age at First Birth 7.82 1 1 3.0 0.00 1.000 RNF123
Coronary Artery Disease (CAD) 2.37 1 0 0.0 0.00 1.000 RNF123
Crohns Disease (2012) 6.14 1 1 3.0 0.00 1.000 RNF123
Fasting Glucose 6.00 1 1 3.0 0.00 1.000 AC074117.10
HDL Cholesterol 4.65 1 1 3.0 0.00 1.000 PABPC4
Schizophrenia 1.92 1 0 0.0 0.00 1.000 DPH2
Triglycerides 36.36 2 1 3.0 0.00 1.000 AC074117.10 PABPC4
Ulcerative Colitis 4.48 1 1 3.0 0.00 1.000 RNF123
Blood Eosinophil Count 0.63 2 0 0.0 0.00 1.000 DPH2 RNF123
Blood Platelet Count 4.65 3 1 3.0 0.00 1.000 AC074117.10 DPH2 PABPC4
Blood Red Count 1.05 3 1 3.0 0.00 1.000 C1orf170 PABPC4 RNF123
Blood White Count 4.58 2 2 6.1 0.00 1.000 AC074117.10 RNF123
Heel T-Score 2.44 2 2 6.1 0.00 1.000 EBF3 RNF123
BMI 5.29 2 2 6.1 0.00 1.000 PABPC4 RNF123
Height 1.39 4 2 6.1 0.05 0.952 AC074117.10 MTX3 PABPC4 RNF123
Waist Hip Ratio (WHR) 1.34 1 0 0.0 0.00 1.000 C1orf170
Systolic Blood Pressure 1.51 2 1 3.0 0.00 1.000 AC074117.10 RNF123
Smoking Status 2.64 1 1 3.0 0.00 1.000 DPH2
Allergy or Eczema 1.43 1 0 0.0 0.00 1.000 AC074117.10
Cardiovascular Disease 3.43 3 1 3.0 0.00 1.000 AC074117.10 PABPC4 RNF123
Hypothyroidism (self reported) 1.71 1 0 0.0 0.00 1.000 C1orf170
Respiratory disease 1.37 1 0 0.0 0.00 1.000 PABPC4
Type 2 Diabetes (T2D) 7.91 3 3 9.1 0.00 1.000 AC074117.10 PABPC4 RNF123
Lung FEV1/FVC ratio 2.53 2 1 3.0 0.00 1.000 C1orf170 PABPC4
Lung FVC 0.89 2 0 0.0 0.00 1.000 PABPC4 RNF123
Neuroticism 2.46 1 0 0.0 0.00 1.000 RNF123
Hair Pigment 0.38 2 1 3.0 0.00 1.000 AC074117.10 PABPC4
Tanning 0.64 1 1 3.0 0.00 1.000 AC074117.10
Number of treatments/medications taken 4.19 2 1 3.0 0.00 1.000 AC074117.10 RNF123
Relative age of first facial hair 2.41 2 0 0.0 0.00 1.000 AC074117.10 DPH2
Systolic blood pressure, automated reading 1.40 1 0 0.0 0.00 1.000 RNF123
Medication: Co-codamol 2.27 1 0 0.0 0.00 1.000 RNF123
Medication: Metformin 5.57 3 0 0.0 0.00 1.000 AC074117.10 PABPC4 RNF123
Diabetes (father) 3.41 2 0 0.0 0.00 1.000 AC074117.10 EBF3
Pack years adult smoking proportion 2.10 1 0 0.0 0.00 1.000 DPH2
Impedance of leg (right) 2.52 3 2 6.1 0.00 1.000 AC074117.10 PABPC4 RNF123
Leg fat-free mass (left) 4.38 3 3 9.1 0.00 1.000 AC074117.10 PABPC4 RNF123
Trunk fat percentage 3.97 2 1 3.0 0.00 1.000 PABPC4 RNF123
Current tobacco smoking 2.55 1 0 0.0 0.00 1.000 DPH2
Maternal smoking around birth 4.39 2 0 0.0 0.00 1.000 DPH2 RNF123
Fed-up feelings 2.54 1 1 3.0 0.00 1.000 RNF123
Taking other prescription medications 3.40 1 1 3.0 0.00 1.000 RNF123
Age when periods started (menarche) 2.47 1 1 3.0 0.00 1.000 DPH2
Heel bone mineral density (BMD) T-score, automated (left) 2.99 1 1 3.0 0.00 1.000 RNF123
Qualifications: CSEs or equivalent 3.17 1 0 0.0 0.00 1.000 RNF123
Hayfever, allergic rhinitis or eczema 1.74 1 0 0.0 0.00 1.000 AC074117.10
Sitting height 2.13 3 1 3.0 0.00 1.000 AC074117.10 DPH2 PABPC4
High blood pressure (mother) 3.34 1 0 0.0 0.00 1.000 C1orf170
Body mass index (BMI) 5.97 2 1 3.0 0.00 1.000 PABPC4 RNF123
Impedance of leg (left) 2.78 3 2 6.1 0.00 1.000 AC074117.10 PABPC4 RNF123
Leg predicted mass (left) 4.30 3 3 9.1 0.00 1.000 AC074117.10 PABPC4 RNF123
Trunk fat mass 4.68 2 2 6.1 0.00 1.000 PABPC4 RNF123
Waist circumference 5.59 2 2 6.1 0.00 1.000 PABPC4 RNF123
Past tobacco smoking 2.13 1 0 0.0 0.00 1.000 DPH2
Alcohol usually taken with meals 3.44 1 0 0.0 0.00 1.000 DPH2
Had menopause 4.44 1 1 3.0 0.00 1.000 AC074117.10
Forced vital capacity (FVC) 0.86 1 0 0.0 0.00 1.000 RNF123
Heel bone mineral density (BMD) T-score, automated (right) 2.89 1 1 3.0 0.00 1.000 RNF123
Qualifications: None of the above 6.02 2 2 6.1 0.00 1.000 DPH2 RNF123
Financial difficulties in last 2 years 2.77 1 0 0.0 0.00 1.000 PABPC4
Heart attack 2.06 1 0 0.0 0.00 1.000 RNF123
Diabetes (self-reported) 7.03 3 2 6.1 0.00 1.000 AC074117.10 PABPC4 RNF123
Medication: Simvastatin 2.10 1 0 0.0 0.00 1.000 AC074117.10
Fluid intelligence score 5.86 2 1 3.0 0.00 1.000 DPH2 RNF123
Neuroticism score 1.83 1 0 0.0 0.00 1.000 RNF123
Weight 5.02 3 3 9.1 0.00 1.000 AC074117.10 PABPC4 RNF123
Impedance of arm (right) 3.72 2 2 6.1 0.00 1.000 AC074117.10 RNF123
Arm fat percentage (right) 4.77 2 2 6.1 0.00 1.000 PABPC4 RNF123
Trunk fat-free mass 3.49 3 2 6.1 0.00 1.000 AC074117.10 PABPC4 RNF123
Hip circumference 3.08 2 2 6.1 0.00 1.000 PABPC4 RNF123
Father's age at death 1.77 1 0 0.0 0.00 1.000 RNF123
Worrier / anxious feelings 2.47 1 0 0.0 0.00 1.000 DPH2
Frequency of tiredness / lethargy in last 2 weeks 1.62 1 0 0.0 0.00 1.000 PABPC4
Number of live births 2.29 1 0 0.0 0.00 1.000 RNF123
Forced expiratory volume in 1-second (FEV1) 1.06 1 0 0.0 0.00 1.000 RNF123
Pulse rate 2.66 1 0 0.0 0.00 1.000 AC074117.10
Qualifications: A levels/AS levels or equivalent 8.68 2 2 6.1 0.00 1.000 DPH2 RNF123
Mouth/teeth dental problems: Dentures 3.75 1 0 0.0 0.00 1.000 RNF123
Medication: Cholesterol lowering 4.33 2 1 3.0 0.00 1.000 AC074117.10 RNF123
Forced expiratory volume in 1-second (FEV1), Best measure 1.18 1 0 0.0 0.00 1.000 RNF123
Impedance of arm (left) 3.51 2 2 6.1 0.00 1.000 AC074117.10 RNF123
Arm fat mass (right) 5.57 2 2 6.1 0.00 1.000 PABPC4 RNF123
Trunk predicted mass 3.48 3 2 6.1 0.00 1.000 AC074117.10 PABPC4 RNF123
Standing height 1.41 2 1 3.0 0.00 1.000 AC074117.10 PABPC4
Exposure to tobacco smoke at home 2.60 1 0 0.0 0.00 1.000 RNF123
Ever highly irritable/argumentative for 2 days 2.47 1 0 0.0 0.00 1.000 RNF123
Qualifications: O levels/GCSEs or equivalent 3.13 2 0 0.0 0.00 1.000 DPH2 RNF123
Headache pain in last month 2.06 1 0 0.0 0.00 1.000 PABPC4
Medication for cholesterol, blood pressure or diabetes 3.11 2 0 0.0 0.00 1.000 AC074117.10 RNF123
Gout (self-reported) 9.64 1 1 3.0 0.00 1.000 AC074117.10
Chronic bronchitis/emphysema (mother) 1.89 1 0 0.0 0.00 1.000 RNF123
Forced vital capacity (FVC), Best measure 1.15 1 0 0.0 0.00 1.000 RNF123
Body fat percentage 4.49 2 1 3.0 0.00 1.000 PABPC4 RNF123
Leg fat percentage (right) 5.29 1 1 3.0 0.00 1.000 RNF123
Arm fat-free mass (right) 4.44 3 2 6.1 0.00 1.000 AC074117.10 PABPC4 RNF123
Exposure to tobacco smoke outside home 2.64 1 0 0.0 0.00 1.000 RNF123
Comparative body size at age 10 1.63 1 0 0.0 0.00 1.000 AC074117.10
Wheeze or whistling in the chest in last year 3.42 1 1 3.0 0.00 1.000 RNF123
Age at first live birth 6.67 2 1 3.0 0.00 1.000 DPH2 RNF123
Health satisfaction 2.49 1 0 0.0 0.00 1.000 RNF123
Qualifications: College or University degree 9.15 2 2 6.1 0.00 1.000 DPH2 RNF123
Neck or shoulder pain in last month 2.58 1 0 0.0 0.00 1.000 PABPC4
Medication: Blood pressure 1.76 1 0 0.0 0.00 1.000 RNF123
Medication: Allopurinol 7.47 1 1 3.0 0.00 1.000 AC074117.10
Medication: Seretide 50 evohaler 2.40 1 0 0.0 0.00 1.000 RNF123
Mean time to correctly identify matches 1.96 1 0 0.0 0.00 1.000 RNF123
Whole body fat mass 5.20 2 1 3.0 0.00 1.000 PABPC4 RNF123
Leg fat mass (right) 5.86 2 1 3.0 0.00 1.000 PABPC4 RNF123
Arm predicted mass (right) 4.40 3 2 6.1 0.00 1.000 AC074117.10 PABPC4 RNF123
Pulse rate, automated reading 5.97 3 3 9.1 0.00 1.000 AC074117.10 PABPC4 RNF123
Alcohol intake frequency. 11.14 4 2 6.1 0.90 0.095 AC074117.10 C1orf170 PABPC4 RNF123
Comparative height size at age 10 2.03 2 1 3.0 0.00 1.000 AC074117.10 DPH2
Overall health rating 4.84 2 1 3.0 0.00 1.000 PABPC4 RNF123
Age at last live birth 5.44 1 1 3.0 0.00 1.000 RNF123
Leg pain on walking 3.68 1 1 3.0 0.00 1.000 RNF123
Qualifications: NVQ or HND or HNC or equivalent 3.00 1 0 0.0 0.00 1.000 RNF123
Knee pain experienced in last month 2.33 1 0 0.0 0.00 1.000 RNF123
Whole body fat-free mass 3.88 3 3 9.1 0.00 1.000 AC074117.10 PABPC4 RNF123
Leg fat-free mass (right) 4.09 3 3 9.1 0.00 1.000 AC074117.10 PABPC4 RNF123
Arm fat percentage (left) 4.75 2 1 3.0 0.00 1.000 PABPC4 RNF123
Average weekly red wine intake 2.68 1 0 0.0 0.00 1.000 DPH2
Mood swings 2.81 1 1 3.0 0.00 1.000 RNF123
Loneliness, isolation 1.60 1 0 0.0 0.00 1.000 RNF123
Long-standing illness, disability or infirmity 2.30 1 0 0.0 0.00 1.000 PABPC4
Ever had bowel cancer screening 3.09 1 0 0.0 0.00 1.000 RNF123
Diabetes diagnosed by doctor 7.17 3 1 3.0 0.00 1.000 AC074117.10 PABPC4 RNF123
Qualifications: nursing, teaching 4.17 2 1 3.0 0.00 1.000 DPH2 RNF123
Medication for cholesterol 2.35 1 0 0.0 0.00 1.000 AC074117.10
Smoking status: Current 2.53 1 0 0.0 0.00 1.000 DPH2
Whole body water mass 3.96 3 3 9.1 0.00 1.000 AC074117.10 PABPC4 RNF123
Leg predicted mass (right) 4.05 3 3 9.1 0.00 1.000 AC074117.10 PABPC4 RNF123
Arm fat mass (left) 5.48 2 2 6.1 0.00 1.000 PABPC4 RNF123
Number of self-reported non-cancer illnesses 2.80 1 0 0.0 0.00 1.000 AC074117.10
Average weekly champagne plus white wine intake 2.32 1 0 0.0 0.00 1.000 RNF123
Miserableness 3.25 1 1 3.0 0.00 1.000 RNF123
Financial situation satisfaction 3.59 1 0 0.0 0.00 1.000 RNF123
High cholesterol (Self-reported) 6.96 1 1 3.0 0.00 1.000 AC074117.10
Medication: Bendroflumethiazide 1.95 1 0 0.0 0.00 1.000 C1orf170
Medication: Atorvastatin 4.60 1 1 3.0 0.00 1.000 AC074117.10
Ever smoked 1.43 1 0 0.0 0.00 1.000 DPH2
Basal metabolic rate 4.18 3 3 9.1 0.00 1.000 AC074117.10 PABPC4 RNF123
Leg fat percentage (left) 5.35 1 1 3.0 0.00 1.000 RNF123
Arm fat-free mass (left) 4.26 3 2 6.1 0.00 1.000 AC074117.10 PABPC4 RNF123
Number of operations (self-reported) 2.09 1 0 0.0 0.00 1.000 C1orf170
Average weekly beer plus cider intake 2.97 1 0 0.0 0.00 1.000 RNF123
Risk taking 2.09 1 0 0.0 0.00 1.000 DPH2
Age started oral contraceptive pill 3.33 1 0 0.0 0.00 1.000 RNF123
Diastolic blood pressure, automated reading 2.86 1 1 3.0 0.00 1.000 RNF123
Cholesterol lowering medication 3.41 1 1 3.0 0.00 1.000 AC074117.10
Pain experienced in last month 4.17 2 0 0.0 0.00 1.000 PABPC4 RNF123
Heart attack/myocardial infarction (self-reported) 1.91 1 0 0.0 0.00 1.000 RNF123
Impedance of whole body 2.93 3 2 6.1 0.00 1.000 AC074117.10 PABPC4 RNF123
Leg fat mass (left) 5.98 2 1 3.0 0.00 1.000 PABPC4 RNF123
Arm predicted mass (left) 4.37 3 2 6.1 0.00 1.000 AC074117.10 PABPC4 RNF123

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.50
GTEx Adipose Visceral Omentum 2 0.0982 1.63
GTEx Adrenal Gland 1 0.0686 1.58
GTEx Artery Aorta 5 0.1680 1.49
GTEx Artery Coronary 1 0.0845 1.56
GTEx Artery Tibial 3 0.0798 1.50
GTEx Brain Caudate basal ganglia 0 0.0000 1.55
GTEx Brain Cerebellar Hemisphere 4 0.2686 1.52
GTEx Brain Cerebellum 4 0.2018 1.54
GTEx Brain Cortex 3 0.2899 1.62
GTEx Brain Frontal Cortex BA9 1 0.1082 1.56
GTEx Brain Hippocampus 0 0.0000 1.47
GTEx Brain Hypothalamus 0 0.0000 1.50
GTEx Brain Nucleus accumbens basal ganglia 1 0.1156 1.51
GTEx Brain Putamen basal ganglia 1 0.1603 1.65
GTEx Breast Mammary Tissue 2 0.1013 1.55
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.49
GTEx Breast Mammary Tissue (Female) 2 0.1217 1.55
GTEx Cells EBV-transformed lymphocytes 1 0.0703 1.58
GTEx Cells Transformed fibroblasts 4 0.0953 1.54
GTEx Colon Sigmoid 1 0.0684 1.53
GTEx Colon Transverse 2 0.0969 1.53
GTEx Esophagus Gastroesophageal Junction 2 0.1384 1.58
GTEx Esophagus Mucosa 4 0.1205 1.54
GTEx Esophagus Muscularis 3 0.0928 1.54
GTEx Heart Atrial Appendage 2 0.1267 1.56
GTEx Heart Left Ventricle 1 0.0654 1.56
GTEx Liver 1 0.1395 1.63
GTEx Lung 2 0.0696 1.56
GTEx Muscle Skeletal 2 0.0692 1.51
GTEx Nerve Tibial 3 0.0694 1.46
GTEx Ovary 0 0.0000 1.66
GTEx Pancreas 1 0.0613 1.61
GTEx Pituitary 1 0.0897 1.48
GTEx Prostate 1 0.1198 1.63
GTEx Skin Not Sun Exposed Suprapubic 4 0.1627 1.58
GTEx Skin Sun Exposed Lower leg 4 0.1099 1.57
GTEx Small Intestine Terminal Ileum 0 0.0000 1.67
GTEx Spleen 5 0.3544 1.61
GTEx Stomach 1 0.0688 1.58
GTEx Testis 3 0.0951 1.50
GTEx Thyroid 3 0.0750 1.49
GTEx Uterus 0 0.0000 1.52
GTEx Vagina 1 0.1575 1.71
GTEx Whole Blood 2 0.1004 1.50
METSIM Adipose 4 0.0868 1.45
NTR Blood 2 0.0833 1.44
ROSMAP Brain Pre-frontal Cortex 4 0.0911 1.57
YFS Blood 2 0.0433 1.38
CommonMind Brain Pre-frontal Cortex 3 0.0558 1.47
TCGA Breast Tumor 0 0.0000 1.41
TCGA Breast Normal 2 0.0475 1.41
TCGA Ovarian Tumor 0 0.0000 1.34
TCGA Prostate Tumor 1 0.0289 1.46