Hub : Traits :

Mouth/teeth dental problems: Mouth ulcers

376 significantly associated models · 46 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 150008790 151547253 2 1 9.4e-08 2.6e-08 7.9e-02 90 ARNT
2 1 160470756 161883083 1 1 2.0e-07 4.4e-07 1.0e+00 100 NDUFS2
3 1 196798989 198436809 1 1 2.6e-09 1.7e-08 1.1e-02 80 DENND1B
4 3 45262393 47544003 9 8 4.7e-28 2.8e-52 NaN NaN CCR2 CCR3 CCR5 FYCO1 LRRC2
5 3 158296916 161490079 6 2 4.9e-19 7.1e-162 2.5e-137 15 IFT80 SCHIP1
6 7 127878155 129284182 1 1 1.0e-09 5.8e-09 1.0e+00 100 IRF5
7 8 89923420 91465011 1 1 2.8e-07 1.5e-11 7.7e-07 46 RP11-37B2.1
8 11 94861491 96256398 1 1 2.7e-07 6.1e-07 1.0e+00 100 AP001877.1
9 17 37101380 38512197 1 1 3.1e-07 1.5e-07 1.5e-01 93 STARD3
10 17 42774693 45796313 19 1 1.6e-11 7.7e-11 1.0e+00 100 KANSL1-AS1
11 19 17473015 18902592 1 1 2.1e-10 1.1e-10 1.0e+00 100 IL12RB1
12 19 46157004 47589895 2 1 6.2e-22 4.4e-20 1.1e-02 92 AC007193.9
13 20 48109475 49505582 1 1 2.2e-07 5.7e-14 4.8e-08 47 CEBPB

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 1.71 1 1 3.0 0.00 1.00000 NDUFS2
Crohns Disease (2017) 3.16 3 1 3.0 0.00 1.00000 AC007193.9 DENND1B STARD3
Irritable Bowel Disease (IBD) 3.73 3 1 3.0 0.00 1.00000 ARNT DENND1B STARD3
Ulcerative Colitis (UC) 4.31 2 2 6.1 0.00 1.00000 IRF5 STARD3
Verbal and Numeric Reasoning (VNR) 0.95 2 0 0.0 0.00 1.00000 AP001877.1 KANSL1-AS1
Breast Cancer 2.47 2 2 6.1 0.00 1.00000 CEBPB KANSL1-AS1
Ovarian Cancer 2.44 1 1 3.0 0.00 1.00000 KANSL1-AS1
Crohns Disease (2012) 2.64 2 0 0.0 0.00 1.00000 KANSL1-AS1 STARD3
HDL Cholesterol 1.66 1 1 3.0 0.00 1.00000 STARD3
Lupus 6.34 1 1 3.0 0.00 1.00000 IRF5
Neuroticism 2.10 1 1 3.0 0.00 1.00000 KANSL1-AS1
Primary Biliary Cirrhosis 8.37 6 3 9.1 -0.06 0.91167 DENND1B IFT80 IRF5 KANSL1-AS1 SCHIP1 STARD3
Rheumatoid Arthritis 3.48 2 1 3.0 0.00 1.00000 IRF5 STARD3
Ulcerative Colitis 3.21 2 1 3.0 0.00 1.00000 IRF5 STARD3
Blood Eosinophil Count 2.76 8 5 15.2 0.39 0.33364 AC007193.9 ARNT CCR5 DENND1B IRF5 KANSL1-AS1 LRRC2 NDUFS2
Blood Platelet Count 0.96 7 4 12.1 -0.43 0.33047 ARNT CEBPB IFT80 IRF5 KANSL1-AS1 NDUFS2 STARD3
Blood Red Count 3.01 6 3 9.1 -0.32 0.53655 AC007193.9 AP001877.1 CCR5 IFT80 KANSL1-AS1 NDUFS2
Blood White Count 6.18 6 4 12.1 -0.14 0.79149 AC007193.9 CCR2 CCR5 KANSL1-AS1 NDUFS2 STARD3
Heel T-Score 2.16 8 4 12.1 -0.40 0.25857 ARNT CCR3 CEBPB FYCO1 IFT80 IL12RB1 IRF5 KANSL1-AS1
BMI 0.89 1 0 0.0 0.00 1.00000 CCR3
Height 0.60 5 3 9.1 -0.19 0.75454 AP001877.1 ARNT CCR5 IRF5 KANSL1-AS1
Waist Hip Ratio (WHR) 2.10 3 2 6.1 0.00 1.00000 IL12RB1 KANSL1-AS1 NDUFS2
Systolic Blood Pressure 1.42 2 2 6.1 0.00 1.00000 IFT80 KANSL1-AS1
Allergy or Eczema 1.09 1 1 3.0 0.00 1.00000 STARD3
Cardiovascular Disease 1.27 1 0 0.0 0.00 1.00000 IFT80
Hypothyroidism (self reported) 2.41 1 0 0.0 0.00 1.00000 IRF5
Respiratory disease 5.70 1 1 3.0 0.00 1.00000 STARD3
Lung FEV1/FVC ratio 1.13 4 1 3.0 -0.85 0.14738 ARNT IL12RB1 KANSL1-AS1 STARD3
Lung FVC 3.45 2 2 6.1 0.00 1.00000 ARNT KANSL1-AS1
Neuroticism 2.75 1 1 3.0 0.00 1.00000 KANSL1-AS1
Hair Pigment 0.10 1 0 0.0 0.00 1.00000 KANSL1-AS1
Tanning 0.38 1 1 3.0 0.00 1.00000 ARNT
Hand grip strength (left) 1.75 1 1 3.0 0.00 1.00000 KANSL1-AS1
Sensitivity / hurt feelings 3.23 2 1 3.0 0.00 1.00000 DENND1B KANSL1-AS1
Frequency of depressed mood in last 2 weeks 1.14 1 0 0.0 0.00 1.00000 KANSL1-AS1
Relative age of first facial hair 3.04 1 1 3.0 0.00 1.00000 KANSL1-AS1
Systolic blood pressure, automated reading 1.56 2 1 3.0 0.00 1.00000 IFT80 KANSL1-AS1
Vitamin and mineral supplements 2.14 1 0 0.0 0.00 1.00000 KANSL1-AS1
Impedance of leg (right) 2.52 5 3 9.1 -0.95 0.00120 AP001877.1 ARNT CCR2 FYCO1 KANSL1-AS1
Leg fat-free mass (left) 1.14 2 0 0.0 0.00 1.00000 CCR2 FYCO1
Trunk fat percentage 1.12 3 1 3.0 0.00 1.00000 ARNT IL12RB1 KANSL1-AS1
Hand grip strength (right) 1.71 1 1 3.0 0.00 1.00000 KANSL1-AS1
Fed-up feelings 1.75 1 1 3.0 0.00 1.00000 KANSL1-AS1
Relative age voice broke 2.45 1 1 3.0 0.00 1.00000 KANSL1-AS1
Taking other prescription medications 1.47 1 0 0.0 0.00 1.00000 STARD3
Age when periods started (menarche) 1.18 1 0 0.0 0.00 1.00000 KANSL1-AS1
Heel bone mineral density (BMD) T-score, automated (left) 0.97 1 0 0.0 0.00 1.00000 KANSL1-AS1
Hayfever, allergic rhinitis or eczema 0.96 1 1 3.0 0.00 1.00000 STARD3
Sitting height 1.52 2 1 3.0 0.00 1.00000 CCR2 KANSL1-AS1
Body mass index (BMI) 0.73 1 0 0.0 0.00 1.00000 DENND1B
Impedance of leg (left) 1.93 4 1 3.0 -0.96 0.00187 AP001877.1 ARNT FYCO1 KANSL1-AS1
Leg predicted mass (left) 1.11 2 0 0.0 0.00 1.00000 CCR2 FYCO1
Trunk fat mass 0.84 2 1 3.0 0.00 1.00000 IL12RB1 KANSL1-AS1
Waist circumference 0.76 1 0 0.0 0.00 1.00000 IL12RB1
Nervous feelings 2.16 2 1 3.0 0.00 1.00000 DENND1B KANSL1-AS1
Frequency of tenseness / restlessness in last 2 weeks 1.94 1 1 3.0 0.00 1.00000 KANSL1-AS1
Hearing difficulty/problems with background noise 1.64 1 0 0.0 0.00 1.00000 KANSL1-AS1
Hair/balding pattern: Pattern 2 1.27 1 0 0.0 0.00 1.00000 KANSL1-AS1
Forced vital capacity (FVC) 2.58 2 2 6.1 0.00 1.00000 ARNT KANSL1-AS1
Heel bone mineral density (BMD) T-score, automated (right) 0.94 1 0 0.0 0.00 1.00000 KANSL1-AS1
Ever unenthusiastic/disinterested for a whole week 1.80 1 0 0.0 0.00 1.00000 KANSL1-AS1
Qualifications: None of the above 2.00 1 1 3.0 0.00 1.00000 AP001877.1
Mouth/teeth dental problems 6.59 5 2 6.1 -0.98 0.00082 CCR2 CCR3 FYCO1 IRF5 KANSL1-AS1
Allergy 2.11 1 1 3.0 0.00 1.00000 STARD3
Neuroticism score 2.33 1 1 3.0 0.00 1.00000 KANSL1-AS1
Impedance of arm (right) 1.56 2 2 6.1 0.00 1.00000 ARNT KANSL1-AS1
Arm fat percentage (right) 0.73 1 0 0.0 0.00 1.00000 IL12RB1
Trunk fat-free mass 0.92 2 0 0.0 0.00 1.00000 AP001877.1 ARNT
Time employed in main current job 1.27 1 0 0.0 0.00 1.00000 KANSL1-AS1
Worrier / anxious feelings 2.17 3 1 3.0 0.00 1.00000 AP001877.1 DENND1B KANSL1-AS1
Hair/balding pattern: Pattern 3 3.11 1 1 3.0 0.00 1.00000 KANSL1-AS1
Number of live births 1.24 1 0 0.0 0.00 1.00000 KANSL1-AS1
Forced expiratory volume in 1-second (FEV1) 2.54 2 2 6.1 0.00 1.00000 ARNT KANSL1-AS1
Qualifications: A levels/AS levels or equivalent 2.26 2 1 3.0 0.00 1.00000 AP001877.1 KANSL1-AS1
Mouth/teeth dental problems: Dentures 1.62 1 0 0.0 0.00 1.00000 STARD3
Asthma 5.08 1 1 3.0 0.00 1.00000 STARD3
Medication: Ibuprofen (e.g. Nurofen) 1.48 1 0 0.0 0.00 1.00000 KANSL1-AS1
Forced expiratory volume in 1-second (FEV1), Best measure 2.48 2 2 6.1 0.00 1.00000 ARNT KANSL1-AS1
Impedance of arm (left) 1.76 2 1 3.0 0.00 1.00000 ARNT KANSL1-AS1
Trunk predicted mass 0.94 2 0 0.0 0.00 1.00000 AP001877.1 ARNT
Standing height 0.60 2 1 3.0 0.00 1.00000 CCR5 KANSL1-AS1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.25 1 0 0.0 0.00 1.00000 DENND1B
Hair/balding pattern: Pattern 4 4.82 1 1 3.0 0.00 1.00000 KANSL1-AS1
Peak expiratory flow (PEF) 1.88 1 1 3.0 0.00 1.00000 KANSL1-AS1
Medication: Paracetamol 2.79 1 1 3.0 0.00 1.00000 KANSL1-AS1
Headache pain in last month 2.38 1 1 3.0 0.00 1.00000 KANSL1-AS1
Hypothyroidism/myxoedema (self-reported) 1.95 1 0 0.0 0.00 1.00000 IRF5
Medication: Ventolin 100micrograms inhaler 3.31 1 1 3.0 0.00 1.00000 STARD3
Forced vital capacity (FVC), Best measure 2.74 2 2 6.1 0.00 1.00000 ARNT KANSL1-AS1
Body fat percentage 0.98 2 1 3.0 0.00 1.00000 ARNT IL12RB1
Leg fat percentage (right) 0.97 1 1 3.0 0.00 1.00000 IL12RB1
Comparative body size at age 10 1.10 1 0 0.0 0.00 1.00000 IFT80
Worry too long after embarrassment 1.52 1 0 0.0 0.00 1.00000 KANSL1-AS1
Wheeze or whistling in the chest in last year 2.06 1 1 3.0 0.00 1.00000 STARD3
Number of children fathered 2.15 1 0 0.0 0.00 1.00000 DENND1B
Qualifications: College or University degree 2.53 4 2 6.1 -0.11 0.89338 AP001877.1 IFT80 IL12RB1 KANSL1-AS1
Medication for pain relief, constipation, heartburn 2.32 1 1 3.0 0.00 1.00000 KANSL1-AS1
Medication: Ibuprofen 1.61 1 0 0.0 0.00 1.00000 KANSL1-AS1
Whole body fat mass 0.73 1 0 0.0 0.00 1.00000 IL12RB1
Leg fat mass (right) 0.65 1 0 0.0 0.00 1.00000 IL12RB1
Alcohol intake frequency. 2.19 1 1 3.0 0.00 1.00000 KANSL1-AS1
Comparative height size at age 10 0.71 2 2 6.1 0.00 1.00000 IL12RB1 KANSL1-AS1
Suffer from 'nerves' 2.10 2 0 0.0 0.00 1.00000 IFT80 KANSL1-AS1
Chest pain or discomfort 0.84 1 0 0.0 0.00 1.00000 STARD3
Leg pain on walking 1.41 1 0 0.0 0.00 1.00000 KANSL1-AS1
Whole body fat-free mass 1.07 4 0 0.0 0.97 0.03002 AP001877.1 ARNT CCR2 FYCO1
Leg fat-free mass (right) 1.49 4 1 3.0 0.95 0.00367 AP001877.1 ARNT CCR2 FYCO1
Arm fat percentage (left) 0.72 1 0 0.0 0.00 1.00000 IL12RB1
Handedness (chirality/laterality): Left-handed 1.78 1 1 3.0 0.00 1.00000 KANSL1-AS1
Mood swings 2.00 1 1 3.0 0.00 1.00000 KANSL1-AS1
Loneliness, isolation 1.46 1 0 0.0 0.00 1.00000 KANSL1-AS1
Friendships satisfaction 1.67 1 0 0.0 0.00 1.00000 AP001877.1
Qualifications: nursing, teaching 1.65 1 0 0.0 0.00 1.00000 AP001877.1
Asthma (self-reported) 5.22 1 1 3.0 0.00 1.00000 STARD3
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.59 2 1 3.0 0.00 1.00000 KANSL1-AS1 STARD3
Whole body water mass 1.13 3 0 0.0 0.00 1.00000 AP001877.1 CCR2 FYCO1
Leg predicted mass (right) 1.48 4 1 3.0 0.95 0.00385 AP001877.1 ARNT CCR2 FYCO1
Average weekly champagne plus white wine intake 1.77 1 0 0.0 0.00 1.00000 KANSL1-AS1
Miserableness 1.75 1 1 3.0 0.00 1.00000 KANSL1-AS1
Guilty feelings 1.68 1 1 3.0 0.00 1.00000 KANSL1-AS1
Financial situation satisfaction 1.98 1 0 0.0 0.00 1.00000 AP001877.1
Medication: Blood pressure 1.05 1 0 0.0 0.00 1.00000 KANSL1-AS1
Medication: Paracetamol 2.60 1 1 3.0 0.00 1.00000 KANSL1-AS1
Basal metabolic rate 0.99 2 0 0.0 0.00 1.00000 CCR2 FYCO1
Leg fat percentage (left) 0.79 1 0 0.0 0.00 1.00000 IL12RB1
Irritability 1.35 1 1 3.0 0.00 1.00000 KANSL1-AS1
Risk taking 0.92 1 0 0.0 0.00 1.00000 IL12RB1
Pain experienced in last month 1.49 1 0 0.0 0.00 1.00000 KANSL1-AS1
Impedance of whole body 2.02 4 2 6.1 -0.99 0.00082 AP001877.1 ARNT FYCO1 KANSL1-AS1
Leg fat mass (left) 0.67 1 0 0.0 0.00 1.00000 IL12RB1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 10 0.286 1.62
GTEx Adipose Visceral Omentum 8 0.393 1.71
GTEx Adrenal Gland 5 0.343 1.62
GTEx Artery Aorta 10 0.336 1.63
GTEx Artery Coronary 9 0.761 1.82
GTEx Artery Tibial 5 0.133 1.52
GTEx Brain Caudate basal ganglia 4 0.435 1.59
GTEx Brain Cerebellar Hemisphere 6 0.403 1.64
GTEx Brain Cerebellum 6 0.303 1.61
GTEx Brain Cortex 9 0.870 1.79
GTEx Brain Frontal Cortex BA9 6 0.649 1.78
GTEx Brain Hippocampus 6 1.145 1.94
GTEx Brain Hypothalamus 4 0.678 1.85
GTEx Brain Nucleus accumbens basal ganglia 6 0.694 1.72
GTEx Brain Putamen basal ganglia 5 0.801 1.82
GTEx Breast Mammary Tissue 7 0.355 1.74
GTEx Breast Mammary Tissue (Male) 7 0.587 1.76
GTEx Breast Mammary Tissue (Female) 6 0.365 1.67
GTEx Cells EBV-transformed lymphocytes 8 0.562 1.69
GTEx Cells Transformed fibroblasts 10 0.238 1.56
GTEx Colon Sigmoid 7 0.479 1.67
GTEx Colon Transverse 10 0.484 1.66
GTEx Esophagus Gastroesophageal Junction 8 0.554 1.70
GTEx Esophagus Mucosa 12 0.361 1.62
GTEx Esophagus Muscularis 13 0.402 1.65
GTEx Heart Atrial Appendage 7 0.443 1.69
GTEx Heart Left Ventricle 6 0.392 1.58
GTEx Liver 5 0.697 1.81
GTEx Lung 10 0.348 1.63
GTEx Muscle Skeletal 7 0.242 1.62
GTEx Nerve Tibial 9 0.208 1.55
GTEx Ovary 6 0.661 1.78
GTEx Pancreas 8 0.490 1.72
GTEx Pituitary 4 0.359 1.73
GTEx Prostate 4 0.479 1.70
GTEx Skin Not Sun Exposed Suprapubic 8 0.325 1.66
GTEx Skin Sun Exposed Lower leg 11 0.302 1.55
GTEx Small Intestine Terminal Ileum 4 0.868 1.91
GTEx Spleen 7 0.496 1.81
GTEx Stomach 7 0.481 1.63
GTEx Testis 11 0.349 1.64
GTEx Thyroid 11 0.275 1.61
GTEx Uterus 6 1.058 2.02
GTEx Vagina 4 0.630 1.74
GTEx Whole Blood 8 0.401 1.82
METSIM Adipose 7 0.152 1.51
NTR Blood 7 0.291 1.82
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.45
YFS Blood 5 0.108 1.54
CommonMind Brain Pre-frontal Cortex 5 0.093 1.48
TCGA Breast Tumor 1 0.130 1.64
TCGA Breast Normal 6 0.143 1.40
TCGA Ovarian Tumor 5 0.171 1.39
TCGA Prostate Tumor 10 0.289 1.52