TWAS hub - RIPK2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.1010	0.0400	2.0e-03	-0.004	NA	0.013	NA	0.000	8.6e-01	NA	4.3e-02	NA	3.2e-01
2	METSIM	Adipose	0.0464	0.0189	5.8e-05	0.058	0.029	0.041	0.025	0.003	3.8e-09	3.0e-05	6.8e-07	9.5e-05	1.2e-01
3	YFS	Blood	0.0599	0.0159	0.0e+00	0.071	0.062	0.071	0.064	0.053	4.1e-22	1.6e-19	3.3e-22	5.4e-20	5.4e-17
4	TCGA	Bladder Urothelial Carcinoma	0.0240	0.0160	3.8e-03	0.019	0.026	0.019	NA	0.020	8.2e-03	2.5e-03	9.1e-03	NA	7.9e-03
5	TCGA	Breast Invasive Carcinoma	0.0560	0.0256	7.9e-10	0.024	0.049	0.048	NA	0.044	8.6e-06	2.4e-10	4.1e-10	NA	1.9e-09
6	TCGA	Thyroid Carcinoma	0.0480	0.0320	8.7e-04	0.016	0.033	0.025	NA	0.024	8.9e-03	3.3e-04	1.6e-03	NA	2.0e-03
7	TCGA	Uterine Corpus Endometrial Carcinoma	0.1280	0.0750	1.5e-03	0.072	0.074	0.136	NA	0.129	4.8e-03	4.2e-03	1.3e-04	NA	1.9e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Mouth/teeth dental problems: Mouth ulcers	7.2	11.5	28.4	2.2	1.0	1.1	3.1	5.3	2.7	5.3
Diverticular disease/diverticulitis (self-reported)	5.2	6.2	7.8	2.7	2.1	2.3	2.6	2.0	2.7	2.8
Unable to work because of sickness or disability	4.5	5.8	8.3	-2.9	-2.1	-2.1	-2.4	-1.7	-2.6	-2.9
Medication: Ventolin 100micrograms inhaler	4.4	5.7	8.2	-2.4	-2.4	-2.5	-2.9	-1.9	-2.5	-2.0
Pulse rate	4.0	6.7	13.1	2.7	1.9	1.9	2.6	2.4	2.6	3.6
Medication: Omeprazole	3.7	4.4	6.4	-2.3	-2.2	-2.1	-2.4	-1.1	-2.5	-1.6
Average weekly beer plus cider intake	3.7	5.4	8.6	-2.2	-2.6	-2.8	-2.7	-0.3	-2.9	-1.3
Medication: Omeprazole (e.g. Zanprol)	3.5	4.2	6.3	-2.0	-2.1	-2.1	-2.4	-1.3	-2.5	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	3.4	5.2	7.7	-2.4	-2.7	-2.8	-2.6	-0.9	-2.5	-1.3
Alzheimer’s Disease (including proxy)	3.3	4.8	9.9	1.6	2.4	2.5	2.4	0.1	3.1	1.9
Mood swings	3.3	6.0	10.2	-3.2	-2.5	-2.8	-2.8	-0.7	-2.7	-1.5
Depression (Nagel 2018)	3.2	4.8	6.7	-1.9	-2.3	-2.6	-2.6	-2.1	-2.0	-1.6
Relative age voice broke	3.0	4.6	8.1	-2.8	-2.2	-2.3	-1.8	-0.9	-2.3	-2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.0	3.5	6.6	-0.2	-2.1	-2.4	-2.6	-1.5	-2.1	-1.0
Neuroticism (2016)	2.9	4.2	7.2	-2.7	-2.0	-2.0	-2.5	-2.0	-1.7	-1.1
Medication: Ramipril	2.7	3.5	6.0	-0.1	-2.2	-2.4	-2.4	-1.7	-1.8	-1.2
Fractured/broken bones in last 5 years	2.6	3.3	4.9	-2.2	-1.4	-1.7	-2.1	-1.9	-1.7	-1.4
Mouth/teeth dental problems	2.5	3.9	11.6	-0.2	-0.5	-0.6	-1.7	-3.1	-1.6	-3.4
Osteoarthritis (self-reported)	2.5	3.2	4.8	-1.9	-2.2	-2.0	-1.3	-0.3	-2.0	-2.0
Smoking status: Current	2.5	4.0	7.1	-2.7	-2.6	-2.3	-1.9	-0.0	-2.2	-0.9
Mother’s age at death	2.5	3.1	5.4	-0.2	1.9	1.9	1.8	2.0	1.5	2.3
Alcohol usually taken with meals	2.4	3.9	6.4	1.4	2.5	2.4	2.3	0.9	2.4	1.5
Current tobacco smoking	2.3	3.8	6.9	-2.4	-2.6	-2.3	-1.8	0.0	-2.2	-0.9
Medication: Levothyroxine sodium	2.2	3.8	5.4	1.7	1.8	2.0	2.0	1.6	2.1	2.3
Supplements: Calcium	2.1	2.3	4.4	1.4	1.9	2.1	1.6	-0.0	1.8	0.4
Chronic bronchitis/emphysema (mother)	2.0	2.3	5.9	-2.4	-1.3	-1.1	-0.8	-1.1	-1.3	-1.9
Wears glasses or contact lenses	2.0	2.4	3.6	1.9	1.1	1.3	1.9	1.6	1.4	1.4
Tinnitus: Yes, now most or all of the time	2.0	2.3	4.0	2.0	1.4	1.2	1.4	1.4	1.6	1.5
Hearing difficulty/problems with background noise	1.9	3.1	7.0	-2.6	-1.8	-1.6	-1.3	-0.4	-2.0	-1.8
Had major operations	1.9	2.2	3.6	-1.9	-1.8	-1.9	-1.6	-0.8	-1.2	-0.6
Neuroticism (Nagel 2018)	1.8	4.2	7.0	-1.9	-2.6	-2.6	-2.4	-1.1	-1.9	-1.1
Depressed Affect (Nagel 2018)	1.7	3.5	5.9	-1.7	-2.3	-2.4	-2.4	-1.2	-1.8	-0.8
Triglycerides	1.7	2.8	5.1	-0.3	-2.3	-2.2	-2.0	-0.6	-2.2	-0.8
Neuroticism	1.7	4.0	5.8	-2.2	-2.3	-2.4	-2.4	-1.0	-1.9	-1.2
Illnesses of mother	1.7	2.1	3.4	0.0	-1.6	-1.7	-1.8	-0.5	-1.7	-1.5
Hypothyroidism/myxoedema (self-reported)	1.7	3.2	6.2	2.5	1.5	1.6	1.6	0.9	1.9	2.2
Age at First Birth	1.6	2.3	7.9	2.8	1.2	1.4	1.6	0.7	1.3	0.4
Medication: Co-codamol	1.6	1.8	2.4	-1.0	-1.3	-1.2	-1.4	-1.4	-1.5	-1.6
Had menopause	1.6	2.0	3.4	0.5	1.1	1.4	1.8	1.6	1.5	1.7
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.5	3.6	-1.7	-1.5	-1.6	-1.8	-0.9	-1.9	-1.6
Loud music exposure frequency	1.6	1.8	3.5	-0.3	-1.6	-1.9	-1.8	-0.7	-1.5	-0.7
Pulse wave peak to peak time	1.6	1.8	4.0	0.0	-0.9	-1.4	-1.6	-1.4	-1.3	-2.0
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	4.1	0.0	1.8	2.0	1.7	-0.2	1.7	-0.1
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	5.1	1.6	0.7	0.8	1.1	1.4	1.3	2.2
Depression (self-reported)	1.5	1.7	3.6	-1.5	-1.3	-1.4	-1.4	0.5	-1.9	-0.8
Pulse wave Arterial Stiffness index	1.5	1.7	3.7	-0.4	0.9	1.4	1.5	1.3	1.2	1.9
Average weekly red wine intake	1.5	2.2	3.9	0.9	2.0	2.0	1.6	0.5	1.6	1.2
Alcohol drinker status: Previous	1.5	1.7	3.0	-0.9	-1.7	-1.7	-1.1	0.1	-1.7	-1.1
Major Depression (MDD)	1.4	1.7	2.4	-1.3	-1.3	-1.5	-1.5	-0.8	-1.5	-0.9
Diabetes (mother)	1.4	1.8	3.4	-0.3	1.0	1.2	1.6	1.8	1.0	1.8
Tense / ‘highly strung’	1.4	2.3	4.1	-2.0	-2.0	-1.9	-1.1	0.6	-1.5	-0.5
Ever highly irritable/argumentative for 2 days	1.4	1.7	4.0	-2.0	-1.3	-1.3	-1.1	-0.5	-1.4	-1.3
Number of children fathered	1.4	1.6	3.1	0.2	-1.6	-1.8	-1.4	-0.1	-1.6	-0.7
Irritability	1.4	2.3	4.6	-1.3	-2.1	-2.0	-1.5	0.7	-1.7	-0.3
Smoking Status	1.3	3.2	11.4	-3.4	-1.8	-1.8	-1.4	-0.0	-1.4	-0.8
Forced vital capacity (FVC)	1.3	5.0	6.9	-2.4	-1.8	-2.0	-2.6	-1.8	-2.5	-2.5
Pain all over the body in last month	1.3	1.4	2.8	-0.7	-1.3	-1.6	-1.6	0.2	-1.7	0.2
Falls in the last year	1.3	1.8	2.7	-1.3	-1.4	-1.1	-1.2	-1.0	-1.6	-1.5
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	4.2	-0.1	1.1	1.1	1.2	1.2	1.4	2.0
Hearing aid user	1.3	1.5	2.6	-0.3	-1.6	-1.4	-1.3	-0.2	-1.6	-1.3
Number of operations (self-reported)	1.3	2.0	3.6	-1.6	-1.9	-1.6	-1.4	-1.4	-1.0	-0.5
Alzheimer’s Disease (in mother)	1.2	1.4	2.7	0.9	1.2	1.3	0.8	-1.4	1.6	0.3
Crohns Disease (2017)	1.2	2.6	10.9	-2.2	0.1	0.4	-0.1	-0.5	-1.5	-3.3
Bipolar Disorder (2011)	1.2	1.2	2.2	0.1	1.4	1.4	1.5	0.2	1.5	0.1
Crohns Disease (2012)	1.2	1.9	10.4	-0.7	0.7	0.8	0.5	-0.7	-0.4	-3.2
Relative age of first facial hair	1.2	2.4	7.2	-2.7	-1.7	-1.6	-1.0	-0.3	-1.6	-0.8
Father’s age at death	1.2	1.7	3.2	1.3	1.3	1.4	0.9	-0.3	1.8	1.5
Forced vital capacity (FVC), Best measure	1.2	4.2	7.9	-2.8	-1.4	-1.6	-2.3	-1.2	-2.4	-2.2
Angina (self-reported)	1.2	1.5	2.5	-1.0	-1.1	-1.4	-1.3	0.2	-1.6	-1.5
Heart disease (mother)	1.2	1.5	3.5	1.5	0.1	0.6	1.2	1.4	0.9	1.9
Pulse rate, automated reading	1.2	3.9	6.2	2.5	2.0	1.9	2.1	-0.0	2.5	1.7
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.4	-1.0	1.0	1.3	1.4	1.8	0.6	0.9
Supplements: Fish oil (including cod liver oil)	1.2	1.5	3.4	0.5	0.9	0.9	1.1	1.8	0.8	1.8
Heart disease (siblings)	1.2	1.5	2.4	1.1	-1.5	-1.6	-1.4	-0.8	-0.9	-1.1
Ulcerative Colitis (UC)	1.1	2.2	4.8	-0.4	1.1	1.6	1.8	2.2	1.1	1.2
Body Mass Index (BMI) (2010)	1.1	1.5	4.4	-2.1	-0.7	-0.7	-1.0	-1.4	-0.9	-1.3
LDL Cholesterol	1.1	1.7	2.5	1.6	1.4	1.3	1.2	1.0	1.4	1.1
Ulcerative Colitis	1.1	1.6	2.4	-0.4	1.4	1.5	1.6	1.5	1.3	0.9
Frequency of depressed mood in last 2 weeks	1.1	1.5	2.4	-1.1	-0.9	-1.3	-1.6	-1.5	-0.9	-1.0
Angina	1.1	1.4	2.2	-0.9	-1.2	-1.4	-1.3	0.1	-1.5	-1.4
Blood clot in the leg (DVT)	1.1	1.4	2.0	0.0	-1.2	-1.4	-1.4	-1.3	-1.0	-1.2
Migraine (self-reported)	1.1	1.4	2.2	-1.5	-1.0	-0.8	-1.4	-0.9	-1.4	-0.9
Medication for cholesterol	1.1	1.7	3.0	0.8	1.7	1.6	1.5	1.5	1.2	0.3
Mean Putamen Volume	1.0	1.2	1.7	-1.3	-1.3	-1.3	-1.3	-0.4	-1.1	-0.7
Primary Biliary Cirrhosis	1.0	1.4	3.9	-0.5	-0.2	-0.4	-1.2	-1.8	-0.9	-2.0
Age when periods started (menarche)	1.0	2.3	4.4	-1.4	-1.5	-1.5	-2.1	-1.6	-1.4	-1.1
Stomach or abdominal pain in last month	1.0	1.3	3.9	-0.8	-1.0	-0.9	-1.0	-2.0	-0.5	-1.2
Medication: Atenolol	1.0	1.3	2.5	1.6	1.1	1.1	0.6	-0.5	1.4	1.2
Qualifications: A levels/AS levels or equivalent	1.0	2.2	3.2	1.4	1.8	1.5	1.3	1.0	1.6	1.6
Asthma	1.0	2.0	2.9	-1.7	-1.6	-1.4	-1.7	-1.3	-1.4	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.0	-0.5	-1.0	-1.2	-1.7	-1.2	-1.3	-0.6
Shortness of breath walking on level ground	1.0	1.1	4.1	0.5	0.3	0.6	0.7	1.0	1.2	2.0
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.5	0.1	-0.9	-1.0	-1.1	-0.0	-1.6	-1.3
Commuting to job workplace: Walk	1.0	1.1	2.3	-0.4	1.2	1.0	1.1	1.5	0.9	1.0
Myopia	1.0	1.5	1.7	1.2	1.3	1.2	1.2	1.1	1.3	1.2
Prostate Cancer	0.9	1.2	2.6	-0.3	1.4	1.6	1.3	-0.5	1.4	-0.1
Fed-up feelings	0.9	1.6	3.1	-1.0	-1.8	-1.7	-1.4	0.5	-1.3	0.3
Medication: Lansoprazole	0.9	1.0	2.6	-0.8	-1.0	-0.7	-0.6	-0.4	-1.2	-1.6
High blood pressure (siblings)	0.9	1.2	2.4	0.8	1.5	1.2	1.1	1.5	0.7	0.4
Medication for pain relief, constipation, heartburn	0.9	1.6	3.0	0.8	1.0	1.1	1.3	1.7	0.9	1.7
Commuting to job workplace: Car/motor vehicle	0.9	1.1	3.7	0.7	-0.9	-0.8	-0.8	-1.9	-0.2	-1.0
Qualifications: nursing, teaching	0.9	1.4	3.0	1.7	0.7	0.8	1.1	1.7	0.7	0.9
Asthma (self-reported)	0.9	1.8	2.6	-1.6	-1.4	-1.2	-1.6	-1.3	-1.3	-0.7
Guilty feelings	0.9	1.4	3.6	-0.4	-1.9	-1.7	-1.4	-0.3	-0.9	-0.1
Worry (Nagel 2018)	0.8	1.8	2.7	-1.0	-1.5	-1.6	-1.6	-1.5	-0.9	-0.8
Average weekly spirits intake	0.8	1.0	1.7	-1.1	-1.3	-1.2	-0.9	-0.2	-1.2	0.1
Diabetes (father)	0.8	1.0	2.9	0.7	-1.1	-0.9	-1.2	-1.7	-0.3	-0.7
Number of incorrect matches in round	0.8	1.4	3.5	-0.2	-1.8	-1.9	-0.9	0.8	-1.3	0.1
Neuroticism score	0.8	1.6	2.8	-1.6	-1.7	-1.6	-1.3	0.0	-1.1	-0.3
Lung cancer (father)	0.8	1.0	1.7	-0.1	-1.2	-1.3	-1.1	-1.3	-0.8	-0.2
Medication: Paracetamol	0.8	1.4	2.6	-1.6	-0.6	-0.7	-1.2	-1.6	-0.8	-1.3
Ever smoked	0.8	1.5	5.0	-2.2	-0.5	-0.5	0.2	1.8	0.0	1.2
Alzheimer’s Disease (in father)	0.7	0.8	1.6	0.3	1.1	0.9	0.9	0.4	1.3	1.0
Coronary Artery Disease (CAD)	0.7	0.9	1.9	-1.4	-0.3	-0.4	-1.1	-0.5	-1.4	-0.7
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.6	0.5	-0.2	0.2	0.8	1.6	0.3	1.6
Ever had hysterectomy (womb removed)	0.7	0.8	2.7	-1.6	-0.7	-0.8	-0.8	-0.7	-0.8	-0.5
Supplements: Zinc	0.7	0.8	2.5	1.6	0.6	0.5	0.8	1.2	0.6	0.4
Severe depression (siblings)	0.7	0.8	4.7	-2.2	-0.2	-0.3	-0.4	0.3	-0.7	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.7	-0.9	-1.3	-1.2	-0.9	-0.1	-1.1	-0.6
Taking other prescription medications	0.7	1.1	1.6	-1.2	-1.3	-1.1	-0.9	-0.7	-0.9	-1.0
Past tobacco smoking	0.7	1.3	5.2	2.3	0.3	0.5	-0.0	-1.5	0.1	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.2	2.1	-0.2	-1.5	-1.4	-0.7	1.4	-1.0	0.8
Worry too long after embarrassment	0.7	1.1	3.5	-1.8	-0.1	0.4	0.9	1.9	0.1	0.4
Qualifications: College or University degree	0.7	2.3	5.1	0.7	2.2	2.2	1.5	0.9	1.4	0.7
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.7	0.1	-1.1	-1.3	-1.1	-0.8	-0.9	-1.0
Intelligence (Savage-Jansen 2018)	0.6	1.9	3.1	1.4	1.4	1.3	1.5	1.8	1.1	0.9
Reaction Time	0.6	1.2	4.0	1.1	-1.4	-0.9	0.1	2.0	-0.6	0.4
HbA1C	0.6	0.6	1.4	1.0	1.0	0.7	0.1	-0.3	0.5	1.2
Hypothyroidism (self reported)	0.6	1.4	2.5	1.6	1.2	1.4	1.2	0.2	1.2	1.1
Average weekly fortified wine intake	0.6	0.7	3.8	-0.1	0.5	0.4	-0.3	-2.0	0.6	-0.2
Had other major operations	0.6	0.8	1.4	-1.2	-1.1	-0.9	-0.9	-0.6	-0.8	-0.2
Exposure to tobacco smoke at home	0.6	0.7	1.7	0.0	-0.7	-0.8	-1.3	-1.3	-0.1	0.2
Pulse wave reflection index	0.6	0.8	2.0	-1.3	1.0	1.4	0.8	0.1	0.4	-0.0
Medication: Amlodipine	0.6	0.8	3.1	0.8	-0.3	0.0	-0.3	-1.8	-0.4	-1.4
Health satisfaction	0.6	0.8	1.8	-0.2	0.6	0.8	1.3	1.3	0.8	0.8
Family relationship satisfaction	0.6	0.7	4.1	-2.0	-0.6	-0.4	-0.2	-0.4	-0.1	-0.2
Supplements: Vitamin C	0.6	0.7	1.7	-1.3	-0.5	-0.6	-0.5	0.5	-1.2	-0.9
Back pain experienced in last month	0.6	0.9	4.6	-2.1	-0.1	-0.3	-0.4	-0.5	-0.4	-0.9
Average weekly champagne plus white wine intake	0.6	0.8	2.6	1.4	-0.5	-0.5	-0.7	-1.6	0.3	-0.4
Miserableness	0.6	1.0	2.7	-1.6	-0.9	-0.8	-1.0	0.7	-0.7	0.8
Irritable Bowel Disease (IBD)	0.5	1.3	2.5	-1.5	0.9	1.4	1.0	0.8	-0.3	-1.6
Rheumatoid Arthritis	0.5	0.7	1.5	0.8	1.0	1.2	0.6	-0.6	0.9	-0.6
Lung FEV1/FVC ratio	0.5	2.3	3.2	1.3	1.5	1.5	1.7	1.3	1.8	1.5
Sensitivity / hurt feelings	0.5	0.8	1.4	-1.2	-1.1	-1.0	-0.9	-0.0	-0.9	-0.5
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	2.2	1.5	0.2	0.2	0.1	0.1	0.5	1.1
Qualifications: None of the above	0.5	1.0	1.7	-0.9	-1.0	-0.9	-1.0	-1.0	-1.0	-1.3
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.6	1.2	0.4	0.5	0.2	-1.1	0.8	0.3
Length of working week for main job	0.5	0.6	1.3	-0.2	-0.4	-0.7	-1.2	-0.9	-0.9	-0.7
Peak expiratory flow (PEF)	0.5	1.1	2.3	-1.3	-0.3	-0.5	-0.9	-1.4	-0.7	-1.5
Exposure to tobacco smoke outside home	0.5	0.6	1.2	-0.3	-1.1	-1.0	-1.0	-0.5	-0.8	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.0	0.7	0.6	0.4	0.4	1.4	0.2	0.8
Emphysema/chronic bronchitis	0.5	0.6	1.5	-1.2	-0.4	0.0	0.3	0.9	-0.9	-0.8
Mean time to correctly identify matches	0.5	0.9	3.2	1.3	-0.6	-0.1	0.6	1.8	-0.1	0.7
Leg pain on walking	0.5	0.7	2.2	-0.6	-0.5	-0.2	-0.4	-1.3	-0.3	-1.5
Smoking status: Previous	0.5	0.7	2.0	-0.8	0.4	0.2	0.6	1.4	0.5	1.1
Osteoporosis (self-reported)	0.5	0.7	1.3	0.8	0.6	0.7	1.0	1.1	0.7	0.8
Medication: Aspirin	0.5	0.6	2.7	0.6	0.2	0.2	0.2	-1.0	0.1	-1.7
Commuting to job workplace: Public transport	0.5	0.6	2.5	-1.6	-0.3	-0.5	-0.9	-0.4	-0.2	0.7
Alcohol drinker status: Never	0.5	0.7	2.1	0.6	-0.2	0.0	1.2	1.5	0.7	0.3
Risk taking	0.5	0.7	3.6	-0.4	-0.2	-0.5	-0.2	1.9	-0.8	0.5
Lung FVC	0.4	2.3	5.2	-0.5	-1.0	-1.1	-1.6	-1.7	-1.6	-2.3
Hearing difficulty/problems: Yes	0.4	0.7	1.5	-0.5	-1.2	-0.9	-0.6	0.4	-1.2	-0.4
High blood pressure	0.4	1.0	1.8	1.0	1.4	1.2	0.4	-1.3	0.9	0.1
Nervous feelings	0.4	0.7	1.8	-0.1	0.9	0.8	1.1	0.3	1.4	0.8
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	2.4	-1.6	0.4	0.5	0.4	-0.3	0.6	-0.0
Heart attack	0.4	0.5	1.1	-1.0	-0.6	-0.4	-0.5	0.3	-0.7	-0.9
Medication: Simvastatin	0.4	0.6	1.1	-0.2	-0.8	-0.6	-0.9	-0.7	-1.1	-0.8
Alcohol intake versus 10 years previously	0.4	0.6	2.2	-1.2	-0.3	-0.1	0.6	1.5	-0.5	-0.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.7	-1.3	-0.4	-0.7	-1.3	-1.0	-1.3	-1.6
Happiness	0.4	0.5	2.4	-1.6	-0.6	-0.4	-0.2	-0.2	-0.2	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	2.3	-1.5	-0.4	-0.7	-1.3	-0.4	-1.4	-1.5
Impedance of arm (left)	0.4	1.8	7.7	0.3	-1.1	-1.0	-1.6	-2.8	0.0	-0.5
Breastfed as a baby	0.4	0.5	1.3	0.8	1.1	1.1	0.6	0.1	0.4	-0.6
Age at first live birth	0.4	0.7	2.1	0.6	0.9	0.9	0.4	-0.8	0.3	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.3	0.1	0.5	1.0	1.1	0.4	0.8	0.4
Suffer from ‘nerves’	0.4	0.7	1.3	-0.4	-0.9	-1.1	-1.0	-1.0	-0.4	-0.5
Medication: Aspirin	0.4	0.5	2.5	0.5	-0.1	-0.1	-0.2	-0.9	-0.2	-1.6
Knee pain experienced in last month	0.4	0.6	2.1	-0.7	-0.8	-0.4	0.3	1.5	-0.4	0.6
Illnesses of father: Heart disease	0.4	0.6	1.6	-1.3	-0.7	-0.7	-0.7	-0.2	-0.7	-0.7
Loneliness, isolation	0.4	0.6	1.1	-0.1	-1.1	-1.1	-1.0	-0.8	-0.6	-0.2
Ever had bowel cancer screening	0.4	0.5	1.3	-0.2	-1.0	-1.1	-0.8	0.1	-0.4	0.6
Mineral and other dietary supplements	0.4	0.6	0.9	0.1	-0.8	-0.8	-0.8	-0.5	-0.8	-1.0
Financial situation satisfaction	0.4	0.5	1.9	-0.3	-0.6	-0.4	-0.1	1.0	0.1	1.4
Medication: Lisinopril	0.4	0.5	0.9	0.3	0.6	0.8	0.7	0.8	0.5	1.0
Pain experienced in last month	0.4	0.7	3.3	1.8	0.8	0.6	0.4	-0.3	0.5	-0.3
Schizophrenia vs Biploar Disorder	0.3	0.4	1.1	0.6	-0.5	-0.3	-0.4	0.9	-1.1	0.1
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.7	-0.9	-0.3	-0.4	0.1	0.7	-0.1	0.8
Systolic Blood Pressure	0.3	1.6	5.5	1.3	0.8	0.8	1.0	2.4	0.3	1.2
Respiratory disease	0.3	0.7	1.2	-1.1	-0.7	-0.7	-0.9	-0.6	-1.1	-0.7
Chronotype (morning person)	0.3	0.7	1.5	-0.9	-0.3	-0.4	-0.8	-1.2	-0.7	-1.0
Number of treatments/medications taken	0.3	0.5	1.7	-0.5	-0.4	-0.4	-0.7	-1.3	-0.3	-0.7
Systolic blood pressure, automated reading	0.3	1.0	3.3	0.3	0.7	0.8	1.0	1.8	0.0	1.3
Impedance of leg (right)	0.3	1.2	4.0	1.2	-0.6	-0.7	-1.6	-2.0	-0.1	-0.3
Townsend deprivation index at recruitment	0.3	0.4	1.1	-1.1	-0.5	-0.4	-0.1	1.0	-0.3	0.6
Maternal smoking around birth	0.3	0.4	1.7	-1.3	0.2	0.3	0.2	-0.6	0.2	-0.7
Qualifications: CSEs or equivalent	0.3	0.4	0.8	0.9	-0.8	-0.9	-0.5	0.0	-0.1	0.6
Serious illness, injury or assault to yourself	0.3	0.4	0.9	-0.8	1.0	0.9	0.6	0.2	0.3	0.2
Hayfever, allergic rhinitis or eczema	0.3	0.7	3.6	-0.2	0.2	0.4	0.3	0.7	0.6	1.9
Chronic bronchitis/emphysema (father)	0.3	0.3	1.8	-1.3	-0.0	-0.0	0.3	-0.2	0.2	-0.4
Waist circumference	0.3	0.9	2.5	-1.6	0.0	0.1	1.0	1.4	0.3	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.8	-0.4	-0.8	-0.5	-1.0	-0.1	-1.3	-1.3
Hip circumference	0.3	1.1	3.3	-1.6	0.3	0.4	1.0	1.8	-0.0	0.8
Noisy workplace	0.3	0.3	0.5	-0.6	-0.7	-0.6	-0.3	-0.6	-0.5	-0.7
Mouth/teeth dental problems: Dentures	0.3	0.4	1.0	-0.8	-1.0	-1.0	-0.4	0.1	-0.4	-0.1
Medication: Cholesterol lowering	0.3	0.5	1.4	1.2	0.1	-0.1	-0.6	-1.0	-0.2	-0.8
Prospective memory result	0.3	0.4	1.3	0.8	-0.1	0.2	-0.2	-1.1	0.1	-0.7
Hair/balding pattern: Pattern 4	0.3	0.8	1.3	-0.9	-1.0	-1.1	-0.9	-0.2	-0.9	-0.9
Birth weight of first child	0.3	0.6	2.6	-0.3	-0.3	-0.3	-0.1	0.2	-1.1	-1.6
Birth weight	0.3	0.5	1.1	-1.0	-0.6	-0.6	-0.7	0.5	-1.0	-0.6
Comparative body size at age 10	0.3	0.9	2.2	-0.5	-0.7	-0.7	-0.9	0.6	-1.5	-1.4
Number of full brothers	0.3	0.4	1.7	1.3	0.6	0.1	-0.1	-0.2	0.4	0.6
Eye problems/disorders: None of the above	0.3	0.3	0.5	-0.5	-0.6	-0.6	-0.7	-0.6	-0.3	-0.1
Alcohol intake frequency.	0.3	0.6	3.5	-0.2	-0.4	-0.3	0.7	1.9	-0.2	0.3
Age at last live birth	0.3	0.5	1.3	-0.8	0.6	0.4	-0.2	-0.8	-0.2	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.0	1.0	-0.4	-0.6	-0.3	-0.8	0.6	0.5
Hypertension (Self-reported)	0.3	0.7	1.8	0.5	1.2	1.0	0.3	-1.3	0.6	0.1
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.9	0.6	0.5	0.4	0.4	-0.6	1.0	-0.0
Long-standing illness, disability or infirmity	0.3	0.5	1.5	-1.2	-0.0	0.2	-0.2	-1.0	-0.3	-1.0
Eye problems/disorders: Cataract	0.3	0.4	1.1	0.2	0.9	1.0	0.5	0.2	0.1	-0.5
Breast cancer (self-reported)	0.3	0.4	1.3	0.0	0.1	0.4	0.7	-0.3	1.2	0.8
Illnesses of father: None of the above (group 1)	0.3	0.3	0.4	0.6	0.7	0.6	0.6	0.3	0.5	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.7	0.0	-0.6	-0.8	-1.1	-0.0	-1.3	-0.8
Eye problems/disorders: Glaucoma	0.3	0.3	0.7	-0.5	-0.4	-0.6	-0.0	0.7	-0.6	-0.8
Medication: Bendroflumethiazide	0.3	0.5	1.6	-0.0	-0.3	-0.2	-0.3	-1.1	-0.7	-1.2
Medication: Atorvastatin	0.3	0.3	0.9	-0.8	0.5	0.4	0.5	1.0	0.0	-0.1
Vascular/heart problems diagnosed by doctor	0.3	0.7	2.3	-1.0	-0.8	-0.7	-0.0	1.5	-0.5	0.3
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.2	-1.1	-0.5	-0.3	-0.4	0.7	-0.6	-0.5
Impedance of whole body	0.3	1.5	6.2	0.8	-0.8	-0.8	-1.5	-2.5	0.1	-0.3
Bipolar Disorder (2018)	0.2	0.3	0.6	-0.4	0.6	0.5	0.0	-0.8	0.6	0.2
Breast Cancer	0.2	0.5	0.8	-0.5	-0.8	-0.7	-0.7	-0.6	-0.9	-0.9
Ovarian Cancer	0.2	0.2	0.6	-0.8	0.2	0.2	0.1	0.6	-0.6	-0.4
Fasting Glucose	0.2	0.2	0.6	-0.8	-0.1	-0.2	-0.4	-0.3	-0.3	-0.6
Lupus	0.2	0.4	1.7	0.6	0.2	-0.0	-0.1	-1.3	0.7	-0.2
Blood Red Count	0.2	1.6	3.2	-1.7	-1.8	-1.7	-1.1	-0.5	-0.7	0.7
Heel T-Score	0.2	1.3	2.5	-0.7	-0.6	-0.7	-1.5	-1.0	-1.4	-1.6
BMI	0.2	1.2	3.5	-1.8	-0.5	-0.5	0.8	1.9	-0.4	0.8
Cardiovascular Disease	0.2	0.7	1.5	-1.2	-0.5	-0.5	-0.8	-1.1	-0.8	-0.5
Hand grip strength (left)	0.2	0.6	1.1	-1.0	-0.6	-0.6	-0.7	-0.1	-0.8	-1.0
Hand grip strength (right)	0.2	0.5	2.0	-1.4	-0.2	-0.1	-0.1	0.8	-0.7	-0.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	-0.2	-0.6	-0.5	-0.6	-0.7	-0.4	0.1
Body mass index (BMI)	0.2	0.8	2.6	-1.4	-0.1	-0.1	0.8	1.6	-0.3	0.5
Impedance of leg (left)	0.2	1.2	4.2	1.2	-0.5	-0.5	-1.4	-2.0	0.0	-0.2
Financial difficulties in last 2 years	0.2	0.3	0.9	0.2	-0.9	-0.8	-0.5	-0.1	-0.0	0.4
Allergy	0.2	0.4	1.1	1.1	0.5	0.3	0.5	0.2	0.3	-0.9
Diabetes (self-reported)	0.2	0.4	0.6	0.4	0.6	0.7	0.7	0.4	0.5	0.8
Fluid intelligence score	0.2	0.3	1.1	-0.3	1.0	0.9	0.2	-0.0	0.3	-0.6
Illnesses of siblings	0.2	0.2	0.8	-0.9	-0.4	-0.0	-0.2	-0.7	-0.2	-0.1
Weight	0.2	0.9	4.6	-2.2	-0.3	-0.4	0.2	1.1	-0.5	0.3
Impedance of arm (right)	0.2	0.8	3.9	1.0	-0.2	-0.1	-0.4	-2.0	0.9	0.0
Worrier / anxious feelings	0.2	0.3	0.8	-0.9	-0.8	-0.5	-0.5	0.2	-0.3	0.0
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.3	-1.1	-0.8	-0.7	-0.3	-0.6	-0.1	-0.1
Glaucoma (self-reported)	0.2	0.2	0.6	0.4	0.4	0.2	0.4	0.7	-0.2	-0.7
Wheeze or whistling in the chest in last year	0.2	0.4	0.9	-1.0	-0.4	-0.4	-0.3	0.8	-0.5	0.4
Medication: Seretide 50 evohaler	0.2	0.2	0.4	0.2	-0.5	-0.7	-0.5	-0.6	0.1	-0.2
Arm predicted mass (right)	0.2	0.9	2.9	-1.7	0.3	0.1	0.5	1.6	-0.4	0.3
Number of full sisters	0.2	0.2	0.5	0.2	-0.5	-0.7	-0.2	0.3	-0.5	-0.4
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	2.0	0.1	-0.0	-0.1	0.1	1.4	-0.2	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.9	0.1	-0.3	-0.2	0.1	1.0	-0.5	0.3
Illnesses of siblings: Diabetes	0.2	0.3	0.8	0.9	-0.5	-0.6	-0.3	0.0	-0.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	2.8	-1.7	0.1	-0.0	0.1	0.5	-0.2	-0.1
Whole body fat-free mass	0.2	0.9	3.2	-1.8	0.4	0.2	0.7	1.5	-0.3	0.3
Friendships satisfaction	0.2	0.2	1.3	-1.1	-0.2	0.0	0.2	-0.2	0.3	0.3
Medication: Gliclazide	0.2	0.2	0.3	-0.5	0.5	0.6	0.3	0.4	0.4	0.3
Whole body water mass	0.2	0.9	3.2	-1.8	0.3	0.1	0.6	1.5	-0.3	0.3
High cholesterol (Self-reported)	0.2	0.4	0.7	0.7	0.5	0.6	0.5	0.8	0.1	0.8
Medication: Paracetamol	0.2	0.3	0.9	-0.9	-0.2	-0.3	-0.6	-0.4	-0.6	-0.5
Illnesses of father: High blood pressure	0.2	0.2	0.7	0.7	-0.3	-0.5	-0.4	-0.2	-0.3	-0.8
Basal metabolic rate	0.2	0.8	3.6	-1.9	0.0	-0.1	0.4	1.4	-0.5	0.2
Ever had prostate specific antigen (PSA) test	0.2	0.2	1.0	1.0	-0.5	-0.5	-0.1	-0.1	0.1	0.3
Ever depressed for a whole week	0.2	0.3	0.9	-0.9	-0.5	-0.5	-0.6	-0.0	-0.4	-0.1
Cholesterol lowering medication	0.2	0.3	1.6	-1.3	-0.4	-0.0	0.3	0.2	-0.3	0.3
Arm predicted mass (left)	0.2	0.8	2.8	-1.3	0.4	0.3	0.8	1.7	-0.1	0.6
Bipolar Disorder or Schizophrenia	0.1	0.1	0.4	-0.1	0.6	0.3	-0.4	-0.6	0.0	0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.2	1.1	-0.4	0.5	0.3	0.2	-0.1	0.1	-1.0
HDL Cholesterol	0.1	0.1	0.5	-0.1	-0.0	0.0	-0.3	-0.7	0.1	-0.6
Blood Eosinophil Count	0.1	0.7	3.2	-0.6	-0.5	-0.2	0.4	1.8	0.1	1.0
Blood White Count	0.1	0.8	2.2	0.1	-1.1	-0.9	0.3	1.5	0.1	1.2
Height	0.1	2.0	3.0	-1.7	-1.3	-1.3	-1.4	-0.8	-1.7	-1.2
Waist Hip Ratio (WHR)	0.1	0.3	0.9	-0.5	-0.0	0.2	0.7	-0.1	0.9	0.7
Allergy or Eczema	0.1	0.2	0.7	-0.4	-0.2	-0.1	-0.5	-0.1	-0.3	0.8
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.3	-0.5	-0.1	0.1	0.3	0.2	-0.0	0.6
Medication for hormone replacement therapy	0.1	0.1	0.4	0.4	-0.1	-0.3	-0.2	0.1	0.1	0.6
Vitamin and mineral supplements	0.1	0.2	0.5	0.7	-0.4	-0.0	-0.2	-0.1	0.2	0.7
Medication: Metformin	0.1	0.1	0.4	-0.6	0.1	-0.0	-0.2	-0.5	-0.0	0.4
Pack years adult smoking proportion	0.1	0.2	0.5	-0.1	-0.2	0.3	0.7	0.7	0.3	0.3
Leg fat-free mass (left)	0.1	0.8	3.3	-1.8	0.2	-0.0	0.6	1.3	-0.2	-0.0
Trunk fat percentage	0.1	0.2	1.0	-1.0	-0.1	-0.1	0.3	-0.1	0.3	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.8	-0.3	-0.5	-0.2	-0.6	0.2	-0.9	-0.7
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	-0.5	0.3	0.1	-0.3	0.0	-0.4	0.2
Multivitamins +/- minerals	0.1	0.1	0.4	-0.5	0.1	-0.3	-0.1	-0.4	-0.3	-0.7
Supplements: Glucosamine	0.1	0.1	0.5	-0.7	0.2	0.3	0.1	-0.4	0.1	-0.2
Sitting height	0.1	0.4	1.0	-0.5	1.0	0.9	0.5	0.6	0.4	0.1
High blood pressure (mother)	0.1	0.2	0.7	-0.9	0.4	-0.0	-0.2	-0.7	0.1	-0.1
Leg predicted mass (left)	0.1	0.7	3.4	-1.8	0.1	-0.0	0.5	1.2	-0.3	-0.1
Trunk fat mass	0.1	0.3	2.0	-1.4	-0.0	-0.2	0.3	0.3	0.0	0.4
Arm fat percentage (right)	0.1	0.3	1.3	-1.1	-0.2	-0.3	0.5	0.6	0.0	0.3
Trunk fat-free mass	0.1	0.8	3.3	-1.8	0.1	-0.1	0.3	1.4	-0.6	0.2
Time employed in main current job	0.1	0.1	0.3	0.3	0.6	0.5	-0.0	-0.2	-0.1	0.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.3	-0.3	-0.3	-0.3	-0.5	0.5	-0.6	0.4
Number of live births	0.1	0.1	0.8	-0.1	-0.0	-0.2	-0.3	-0.9	-0.0	-0.0
Arm fat mass (right)	0.1	0.6	1.5	-1.1	0.1	0.0	0.8	1.2	0.1	0.7
Trunk predicted mass	0.1	0.9	3.4	-1.8	0.1	-0.1	0.3	1.4	-0.6	0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	0.5	0.4	-0.0	0.0	0.5	0.1	0.3
Headache pain in last month	0.1	0.2	0.5	-0.5	0.1	0.0	-0.4	-0.7	0.0	-0.7
Gout (self-reported)	0.1	0.1	0.4	0.4	-0.0	0.1	-0.1	0.5	-0.2	0.6
Body fat percentage	0.1	0.3	1.6	-1.3	-0.4	-0.5	-0.1	0.0	-0.2	0.2
Leg fat percentage (right)	0.1	0.2	1.1	-1.0	-0.2	-0.4	-0.1	0.3	-0.4	0.0
Arm fat-free mass (right)	0.1	0.8	3.0	-1.7	0.3	0.1	0.5	1.3	-0.4	0.1
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.6	-0.4	-0.1	-0.3	-0.1	0.8	-0.1	0.3
Neck or shoulder pain in last month	0.1	0.2	1.3	-1.1	-0.2	-0.0	-0.1	-0.3	0.1	0.2
Medication: Allopurinol	0.1	0.1	0.3	-0.3	-0.3	-0.1	0.0	0.1	-0.0	0.5
Whole body fat mass	0.1	0.4	2.0	-1.4	-0.0	-0.2	0.3	0.5	-0.0	0.3
Leg fat mass (right)	0.1	0.3	1.3	-1.1	0.3	0.1	0.5	0.7	-0.0	0.2
Comparative height size at age 10	0.1	0.3	0.6	-0.8	-0.4	-0.5	-0.8	0.2	-0.6	-0.1
Overall health rating	0.1	0.1	0.5	-0.7	-0.1	0.2	0.6	0.1	0.2	-0.0
Chest pain or discomfort	0.1	0.2	0.3	-0.3	0.5	0.5	0.3	-0.3	0.3	-0.6
Leg fat-free mass (right)	0.1	0.8	3.1	-1.8	0.3	0.2	0.7	1.3	-0.1	0.0
Arm fat percentage (left)	0.1	0.4	1.6	-1.3	-0.5	-0.6	0.1	0.4	-0.3	0.1
Leg predicted mass (right)	0.1	0.8	3.5	-1.9	0.2	0.1	0.7	1.2	-0.2	-0.1
Arm fat mass (left)	0.1	0.4	1.5	-1.2	-0.2	-0.3	0.5	0.9	-0.1	0.4
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.1	-0.0	0.2	0.5	0.2	0.6	0.6
Ever taken oral contraceptive pill	0.1	0.2	0.5	0.7	0.3	0.2	0.2	0.6	0.1	0.1
Medication: Blood pressure	0.1	0.1	0.3	-0.4	-0.5	-0.3	-0.1	-0.4	-0.4	0.2
Leg fat percentage (left)	0.1	0.2	1.2	-1.1	-0.2	-0.4	-0.1	0.1	-0.4	0.0
Arm fat-free mass (left)	0.1	0.7	2.1	-1.4	0.5	0.3	0.6	1.4	-0.2	0.4
Age started oral contraceptive pill	0.1	0.1	0.3	-0.4	0.2	0.3	0.2	0.3	0.3	0.6
Diastolic blood pressure, automated reading	0.1	0.2	0.6	-0.0	0.5	0.5	0.6	0.8	-0.3	0.5
Commuting to job workplace: Cycle	0.1	0.1	0.3	0.1	0.5	0.4	0.3	0.1	-0.2	-0.4
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	0.5	0.2	0.2	0.3	-0.2	0.4	0.4
Pack years of smoking	0.1	0.1	0.2	-0.2	-0.4	-0.0	0.4	0.5	0.1	0.2
Leg fat mass (left)	0.1	0.3	1.1	-1.1	0.3	0.1	0.5	0.7	-0.0	0.1
Schizophrenia (2018)	0.0	0.1	0.4	0.1	0.2	-0.1	-0.6	-0.2	-0.4	-0.0
Schizophrenia (2014)	0.0	0.1	0.1	0.1	0.3	0.2	-0.2	0.2	-0.1	0.3
Blood Platelet Count	0.0	0.3	0.6	-0.8	-0.8	-0.7	-0.5	-0.6	-0.1	0.1
Hair Pigment	0.0	0.3	1.0	-0.5	-0.3	-0.4	-0.4	-1.0	-0.3	-0.6
Tanning	0.0	0.2	0.5	0.1	0.6	0.5	0.2	-0.7	0.1	-0.7
Hair/balding pattern: Pattern 2	0.0	0.1	0.2	0.4	-0.0	0.2	0.2	0.2	0.2	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.1	0.1	0.1	-0.3	-0.4	0.0	-0.0	0.3	0.2
Standing height	0.0	0.4	2.0	-1.4	-0.1	-0.3	-0.7	-0.6	-0.2	-0.2
Medication: Blood pressure	0.0	0.1	0.3	0.3	0.5	0.3	-0.0	0.1	0.0	-0.1
Medication: Ibuprofen	0.0	0.1	0.1	-0.1	-0.3	-0.3	0.0	-0.3	0.2	0.1
Diabetes diagnosed by doctor	0.0	0.1	0.2	0.2	0.2	0.3	0.3	0.0	0.2	0.4

Hub : Genes

RIPK2

Models

Trait associations