Hub : Traits :

Qualifications: nursing, teaching

44 significantly associated models · 19 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 71163715 73435171 1 1 1.1e-09 5.0e-07 0.099 89 NEGR1
2 1 201164764 202607593 2 1 2.3e-07 5.6e-08 1.000 100 LMOD1
3 1 242723236 244345666 1 1 2.7e-07 4.5e-05 0.100 84 SDCCAG8
4 3 49030828 50800146 4 1 5.0e-08 1.2e-06 0.026 79 MST1R
5 12 122713991 124591385 8 1 2.8e-10 1.1e-07 0.273 96 SETD8
6 15 51725395 53168900 1 1 1.1e-07 7.9e-05 0.825 100 GNB5

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 5.14 1 1 3.0 0.00 1.0000 MST1R
Irritable Bowel Disease (IBD) 6.79 1 1 3.0 0.00 1.0000 MST1R
Ulcerative Colitis (UC) 5.28 1 1 3.0 0.00 1.0000 MST1R
Major Depression (MDD) 5.96 1 1 3.0 0.00 1.0000 NEGR1
Reaction Time 1.88 1 0 0.0 0.00 1.0000 MST1R
Verbal and Numeric Reasoning (VNR) 12.17 4 2 6.1 -0.96 0.0431 LMOD1 MST1R NEGR1 SETD8
Breast Cancer 2.92 2 0 0.0 0.00 1.0000 MST1R NEGR1
Prostate Cancer 2.39 1 0 0.0 0.00 1.0000 MST1R
Age at First Birth 8.62 1 1 3.0 0.00 1.0000 MST1R
Body Mass Index (BMI) (2010) 10.55 2 1 3.0 0.00 1.0000 LMOD1 NEGR1
Coronary Artery Disease (CAD) 3.67 2 0 0.0 0.00 1.0000 LMOD1 MST1R
Crohns Disease (2012) 5.62 1 1 3.0 0.00 1.0000 MST1R
Schizophrenia 3.61 1 1 3.0 0.00 1.0000 SETD8
Type 2 Diabetes (T2D) 2.49 1 0 0.0 0.00 1.0000 SETD8
Ulcerative Colitis 5.34 1 1 3.0 0.00 1.0000 MST1R
Blood Eosinophil Count 1.98 2 1 3.0 0.00 1.0000 MST1R SETD8
Blood Platelet Count 2.55 1 1 3.0 0.00 1.0000 SETD8
Blood Red Count 0.98 2 1 3.0 0.00 1.0000 MST1R SETD8
Blood White Count 2.33 2 1 3.0 0.00 1.0000 MST1R SDCCAG8
Heel T-Score 3.56 3 3 9.1 0.00 1.0000 MST1R NEGR1 SETD8
BMI 12.60 4 3 9.1 0.45 0.5479 GNB5 LMOD1 MST1R NEGR1
Height 2.08 2 1 3.0 0.00 1.0000 MST1R SETD8
Waist Hip Ratio (WHR) 6.84 1 1 3.0 0.00 1.0000 SETD8
Systolic Blood Pressure 1.65 2 0 0.0 0.00 1.0000 MST1R SDCCAG8
Allergy or Eczema 3.22 2 0 0.0 0.00 1.0000 NEGR1 SETD8
Cardiovascular Disease 3.64 3 1 3.0 0.00 1.0000 LMOD1 NEGR1 SDCCAG8
Hypothyroidism (self reported) 1.91 1 0 0.0 0.00 1.0000 SETD8
Respiratory disease 2.93 2 0 0.0 0.00 1.0000 NEGR1 SETD8
Type 2 Diabetes (T2D) 3.62 2 0 0.0 0.00 1.0000 MST1R SETD8
Lung FEV1/FVC ratio 2.13 3 1 3.0 0.00 1.0000 LMOD1 NEGR1 SETD8
Lung FVC 1.57 2 0 0.0 0.00 1.0000 MST1R SETD8
Neuroticism 1.56 1 0 0.0 0.00 1.0000 MST1R
Chronotype (morning person) 3.46 2 0 0.0 0.00 1.0000 LMOD1 SDCCAG8
Hair Pigment 0.27 1 1 3.0 0.00 1.0000 SETD8
Tanning 0.30 1 0 0.0 0.00 1.0000 NEGR1
Number of treatments/medications taken 6.51 3 1 3.0 0.00 1.0000 MST1R NEGR1 SDCCAG8
Relative age of first facial hair 1.98 1 0 0.0 0.00 1.0000 NEGR1
Other serious medical condition/disability diagnosed by doctor 2.89 1 0 0.0 0.00 1.0000 NEGR1
Systolic blood pressure, automated reading 1.94 1 0 0.0 0.00 1.0000 MST1R
Vitamin and mineral supplements 2.43 1 0 0.0 0.00 1.0000 NEGR1
Medication: Co-codamol 4.46 1 0 0.0 0.00 1.0000 MST1R
Impedance of leg (right) 3.96 3 2 6.1 0.00 1.0000 LMOD1 MST1R NEGR1
Leg fat-free mass (left) 6.01 5 4 12.1 -0.29 0.6400 GNB5 LMOD1 MST1R NEGR1 SETD8
Trunk fat percentage 7.22 4 3 9.1 -0.49 0.5141 GNB5 LMOD1 MST1R NEGR1
Hand grip strength (right) 1.35 1 0 0.0 0.00 1.0000 MST1R
Current tobacco smoking 3.83 1 0 0.0 0.00 1.0000 NEGR1
Maternal smoking around birth 3.38 1 0 0.0 0.00 1.0000 MST1R
Fed-up feelings 5.29 1 1 3.0 0.00 1.0000 MST1R
Taking other prescription medications 6.73 2 1 3.0 0.00 1.0000 MST1R NEGR1
Age when periods started (menarche) 6.21 2 1 3.0 0.00 1.0000 MST1R NEGR1
Heel bone mineral density (BMD) T-score, automated (left) 2.40 1 0 0.0 0.00 1.0000 MST1R
Qualifications: CSEs or equivalent 3.49 1 0 0.0 0.00 1.0000 MST1R
High blood pressure 3.77 3 0 0.0 0.00 1.0000 LMOD1 NEGR1 SDCCAG8
Hayfever, allergic rhinitis or eczema 3.18 2 0 0.0 0.00 1.0000 NEGR1 SETD8
Multivitamins +/- minerals 2.73 1 0 0.0 0.00 1.0000 NEGR1
Stomach or abdominal pain in last month 2.79 1 0 0.0 0.00 1.0000 NEGR1
Sitting height 4.09 1 1 3.0 0.00 1.0000 SETD8
Body mass index (BMI) 12.82 4 3 9.1 -0.52 0.4812 GNB5 LMOD1 MST1R NEGR1
Impedance of leg (left) 4.43 5 2 6.1 0.29 0.6396 GNB5 LMOD1 MST1R NEGR1 SETD8
Leg predicted mass (left) 5.96 5 4 12.1 -0.29 0.6400 GNB5 LMOD1 MST1R NEGR1 SETD8
Trunk fat mass 8.73 5 3 9.1 -0.44 0.4557 GNB5 LMOD1 MST1R NEGR1 SETD8
Waist circumference 8.77 4 3 9.1 -0.44 0.5597 GNB5 LMOD1 MST1R NEGR1
Number of incorrect matches in round 2.85 1 0 0.0 0.00 1.0000 LMOD1
Past tobacco smoking 1.93 1 0 0.0 0.00 1.0000 GNB5
Alcohol usually taken with meals 5.62 2 0 0.0 0.00 1.0000 LMOD1 NEGR1
Frequency of tenseness / restlessness in last 2 weeks 1.99 1 0 0.0 0.00 1.0000 MST1R
Had menopause 2.66 1 0 0.0 0.00 1.0000 SETD8
Forced vital capacity (FVC) 1.02 1 0 0.0 0.00 1.0000 MST1R
Heel bone mineral density (BMD) T-score, automated (right) 2.34 1 0 0.0 0.00 1.0000 MST1R
Qualifications: None of the above 13.58 6 3 9.1 -0.97 0.0014 GNB5 LMOD1 MST1R NEGR1 SDCCAG8 SETD8
Financial difficulties in last 2 years 3.65 1 0 0.0 0.00 1.0000 SDCCAG8
Mouth/teeth dental problems 3.91 1 0 0.0 0.00 1.0000 SDCCAG8
Allergy 3.66 2 1 3.0 0.00 1.0000 NEGR1 SETD8
Pain all over the body in last month 2.31 1 0 0.0 0.00 1.0000 MST1R
Diabetes (self-reported) 3.11 1 0 0.0 0.00 1.0000 MST1R
Fluid intelligence score 11.10 4 2 6.1 0.99 0.0074 LMOD1 MST1R NEGR1 SETD8
Neuroticism score 1.76 1 0 0.0 0.00 1.0000 MST1R
Weight 9.32 5 3 9.1 -0.42 0.4871 GNB5 LMOD1 MST1R NEGR1 SETD8
Impedance of arm (right) 5.92 3 3 9.1 0.00 1.0000 LMOD1 MST1R NEGR1
Arm fat percentage (right) 9.79 4 3 9.1 -0.45 0.5501 GNB5 LMOD1 MST1R NEGR1
Trunk fat-free mass 3.54 4 3 9.1 -0.28 0.7196 LMOD1 MST1R NEGR1 SETD8
Hip circumference 8.73 5 4 12.1 -0.25 0.6817 GNB5 LMOD1 MST1R NEGR1 SETD8
Alcohol intake versus 10 years previously 8.73 2 1 3.0 0.00 1.0000 MST1R NEGR1
Father's age at death 3.61 1 0 0.0 0.00 1.0000 MST1R
Frequency of tiredness / lethargy in last 2 weeks 3.34 1 0 0.0 0.00 1.0000 LMOD1
Number of live births 3.16 1 0 0.0 0.00 1.0000 MST1R
Forced expiratory volume in 1-second (FEV1) 1.10 1 0 0.0 0.00 1.0000 MST1R
Pulse rate 1.82 1 0 0.0 0.00 1.0000 LMOD1
Noisy workplace 5.23 1 0 0.0 0.00 1.0000 LMOD1
Qualifications: A levels/AS levels or equivalent 17.51 5 3 9.1 0.96 0.0094 LMOD1 MST1R NEGR1 SDCCAG8 SETD8
Mouth/teeth dental problems: Dentures 5.43 3 0 0.0 0.00 1.0000 MST1R NEGR1 SDCCAG8
Asthma 2.57 1 0 0.0 0.00 1.0000 SETD8
Forced expiratory volume in 1-second (FEV1), Best measure 1.36 1 0 0.0 0.00 1.0000 MST1R
Impedance of arm (left) 5.98 3 3 9.1 0.00 1.0000 LMOD1 MST1R NEGR1
Arm fat mass (right) 11.68 4 3 9.1 -0.47 0.5286 GNB5 LMOD1 MST1R NEGR1
Trunk predicted mass 3.53 4 3 9.1 -0.27 0.7329 LMOD1 MST1R NEGR1 SETD8
Standing height 1.96 1 1 3.0 0.00 1.0000 SETD8
Exposure to tobacco smoke at home 3.26 1 0 0.0 0.00 1.0000 MST1R
Breastfed as a baby 3.25 1 0 0.0 0.00 1.0000 SETD8
Seen doctor (GP) for nerves, anxiety, tension or depression 5.81 1 1 3.0 0.00 1.0000 NEGR1
Ever highly irritable/argumentative for 2 days 3.64 1 0 0.0 0.00 1.0000 MST1R
Qualifications: O levels/GCSEs or equivalent 8.79 2 1 3.0 0.00 1.0000 MST1R SETD8
Medication: Paracetamol 4.79 1 0 0.0 0.00 1.0000 SDCCAG8
Medication for cholesterol, blood pressure or diabetes 3.29 2 0 0.0 0.00 1.0000 MST1R NEGR1
Chronic bronchitis/emphysema (mother) 2.80 1 0 0.0 0.00 1.0000 MST1R
Forced vital capacity (FVC), Best measure 1.22 1 0 0.0 0.00 1.0000 MST1R
Body fat percentage 8.90 3 3 9.1 0.00 1.0000 LMOD1 MST1R NEGR1
Leg fat percentage (right) 10.88 3 3 9.1 0.00 1.0000 LMOD1 MST1R NEGR1
Arm fat-free mass (right) 5.21 4 3 9.1 -0.40 0.6008 LMOD1 MST1R NEGR1 SETD8
Exposure to tobacco smoke outside home 6.20 2 1 3.0 0.00 1.0000 MST1R SDCCAG8
Comparative body size at age 10 9.41 3 1 3.0 0.00 1.0000 GNB5 LMOD1 NEGR1
Number of full brothers 2.03 1 0 0.0 0.00 1.0000 SDCCAG8
Seen a psychiatrist for nerves, anxiety, tension or depression 1.99 1 0 0.0 0.00 1.0000 NEGR1
Wheeze or whistling in the chest in last year 6.49 2 1 3.0 0.00 1.0000 LMOD1 MST1R
Age at first live birth 7.75 2 1 3.0 0.00 1.0000 LMOD1 MST1R
Health satisfaction 5.85 1 1 3.0 0.00 1.0000 LMOD1
Shortness of breath walking on level ground 4.95 1 0 0.0 0.00 1.0000 LMOD1
Qualifications: College or University degree 19.87 6 4 12.1 0.95 0.0041 GNB5 LMOD1 MST1R NEGR1 SDCCAG8 SETD8
Medication for pain relief, constipation, heartburn 4.80 2 0 0.0 0.00 1.0000 LMOD1 SDCCAG8
Medication: Blood pressure 2.35 1 0 0.0 0.00 1.0000 NEGR1
Mean time to correctly identify matches 2.22 1 0 0.0 0.00 1.0000 MST1R
Whole body fat mass 10.55 4 3 9.1 -0.49 0.5074 GNB5 LMOD1 MST1R NEGR1
Leg fat mass (right) 12.22 3 3 9.1 0.00 1.0000 LMOD1 MST1R NEGR1
Arm predicted mass (right) 5.42 4 3 9.1 -0.41 0.5898 LMOD1 MST1R NEGR1 SETD8
Pulse rate, automated reading 5.06 3 3 9.1 0.00 1.0000 LMOD1 MST1R NEGR1
Alcohol intake frequency. 6.19 3 1 3.0 0.00 1.0000 MST1R NEGR1 SETD8
Comparative height size at age 10 3.19 2 1 3.0 0.00 1.0000 MST1R SETD8
Overall health rating 8.74 3 2 6.1 0.00 1.0000 LMOD1 MST1R SDCCAG8
Age at last live birth 7.80 1 1 3.0 0.00 1.0000 MST1R
Leg pain on walking 5.13 1 1 3.0 0.00 1.0000 MST1R
Qualifications: NVQ or HND or HNC or equivalent 4.91 2 0 0.0 0.00 1.0000 MST1R SDCCAG8
Commuting to job workplace: Car/motor vehicle 4.48 1 0 0.0 0.00 1.0000 NEGR1
Medication: Aspirin 1.89 1 0 0.0 0.00 1.0000 LMOD1
Knee pain experienced in last month 4.53 1 0 0.0 0.00 1.0000 MST1R
Hypertension (Self-reported) 3.33 3 0 0.0 0.00 1.0000 LMOD1 NEGR1 SDCCAG8
Smoking status: Previous 2.90 1 0 0.0 0.00 1.0000 GNB5
Whole body fat-free mass 4.58 4 4 12.1 -0.31 0.6943 LMOD1 MST1R NEGR1 SETD8
Leg fat-free mass (right) 5.26 5 4 12.1 -0.26 0.6769 GNB5 LMOD1 MST1R NEGR1 SETD8
Arm fat percentage (left) 9.64 4 3 9.1 -0.46 0.5418 GNB5 LMOD1 MST1R NEGR1
Average weekly red wine intake 5.76 2 0 0.0 0.00 1.0000 NEGR1 SETD8
Mood swings 2.94 1 0 0.0 0.00 1.0000 MST1R
Loneliness, isolation 2.72 1 0 0.0 0.00 1.0000 MST1R
Long-standing illness, disability or infirmity 5.00 1 0 0.0 0.00 1.0000 NEGR1
Ever had bowel cancer screening 2.62 1 0 0.0 0.00 1.0000 MST1R
Diabetes diagnosed by doctor 2.75 1 0 0.0 0.00 1.0000 MST1R
Mouth/teeth dental problems: Mouth ulcers 2.65 1 0 0.0 0.00 1.0000 SDCCAG8
Asthma (self-reported) 2.78 1 0 0.0 0.00 1.0000 SETD8
Osteoarthritis (self-reported) 4.52 1 0 0.0 0.00 1.0000 MST1R
Medication: Aspirin 2.05 1 0 0.0 0.00 1.0000 LMOD1
Illnesses of father: None of the above (group 1) 4.13 1 0 0.0 0.00 1.0000 GNB5
Whole body water mass 4.65 4 4 12.1 -0.31 0.6949 LMOD1 MST1R NEGR1 SETD8
Leg predicted mass (right) 5.25 5 4 12.1 -0.25 0.6826 GNB5 LMOD1 MST1R NEGR1 SETD8
Arm fat mass (left) 11.33 4 3 9.1 -0.47 0.5334 GNB5 LMOD1 MST1R NEGR1
Number of self-reported non-cancer illnesses 5.32 1 1 3.0 0.00 1.0000 NEGR1
Average weekly champagne plus white wine intake 3.98 1 0 0.0 0.00 1.0000 MST1R
Miserableness 4.99 1 1 3.0 0.00 1.0000 MST1R
Mother's age at death 3.02 1 0 0.0 0.00 1.0000 SDCCAG8
Financial situation satisfaction 5.84 2 0 0.0 0.00 1.0000 MST1R SDCCAG8
Commuting to job workplace: Public transport 3.45 1 0 0.0 0.00 1.0000 NEGR1
Medication: Blood pressure 2.21 1 0 0.0 0.00 1.0000 LMOD1
Medication: Paracetamol 3.20 1 0 0.0 0.00 1.0000 SDCCAG8
Alcohol drinker status: Never 1.94 1 0 0.0 0.00 1.0000 SETD8
Basal metabolic rate 5.81 5 4 12.1 -0.34 0.5766 GNB5 LMOD1 MST1R NEGR1 SETD8
Leg fat percentage (left) 11.08 3 3 9.1 0.00 1.0000 LMOD1 MST1R NEGR1
Arm fat-free mass (left) 5.90 4 3 9.1 -0.41 0.5851 LMOD1 MST1R NEGR1 SETD8
Number of operations (self-reported) 4.82 1 0 0.0 0.00 1.0000 NEGR1
Average weekly beer plus cider intake 6.44 3 0 0.0 0.00 1.0000 GNB5 MST1R NEGR1
Age started oral contraceptive pill 3.87 2 0 0.0 0.00 1.0000 GNB5 MST1R
Diastolic blood pressure, automated reading 7.87 4 4 12.1 -1.00 0.0016 LMOD1 MST1R SDCCAG8 SETD8
Commuting to job workplace: Cycle 2.82 1 0 0.0 0.00 1.0000 NEGR1
Vascular/heart problems diagnosed by doctor 3.86 3 0 0.0 0.00 1.0000 LMOD1 NEGR1 SDCCAG8
Pain experienced in last month 5.11 1 1 3.0 0.00 1.0000 MST1R
Impedance of whole body 4.99 3 3 9.1 0.00 1.0000 LMOD1 MST1R NEGR1
Leg fat mass (left) 12.35 3 3 9.1 0.00 1.0000 LMOD1 MST1R NEGR1
Arm predicted mass (left) 5.92 4 3 9.1 -0.42 0.5795 LMOD1 MST1R NEGR1 SETD8

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.0573 1.54
GTEx Adipose Visceral Omentum 2 0.0982 1.67
GTEx Adrenal Gland 0 0.0000 1.53
GTEx Artery Aorta 2 0.0672 1.60
GTEx Artery Coronary 0 0.0000 1.56
GTEx Artery Tibial 2 0.0532 1.60
GTEx Brain Caudate basal ganglia 0 0.0000 1.52
GTEx Brain Cerebellar Hemisphere 1 0.0672 1.68
GTEx Brain Cerebellum 0 0.0000 1.64
GTEx Brain Cortex 0 0.0000 1.56
GTEx Brain Frontal Cortex BA9 0 0.0000 1.60
GTEx Brain Hippocampus 0 0.0000 1.59
GTEx Brain Hypothalamus 0 0.0000 1.70
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.60
GTEx Brain Putamen basal ganglia 0 0.0000 1.62
GTEx Breast Mammary Tissue 1 0.0507 1.66
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.59
GTEx Breast Mammary Tissue (Female) 2 0.1217 1.61
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.67
GTEx Cells Transformed fibroblasts 4 0.0953 1.61
GTEx Colon Sigmoid 0 0.0000 1.64
GTEx Colon Transverse 1 0.0484 1.65
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.63
GTEx Esophagus Mucosa 1 0.0301 1.63
GTEx Esophagus Muscularis 2 0.0619 1.67
GTEx Heart Atrial Appendage 1 0.0633 1.63
GTEx Heart Left Ventricle 1 0.0654 1.60
GTEx Liver 1 0.1395 1.59
GTEx Lung 0 0.0000 1.59
GTEx Muscle Skeletal 1 0.0346 1.63
GTEx Nerve Tibial 1 0.0231 1.57
GTEx Ovary 0 0.0000 1.73
GTEx Pancreas 4 0.2451 1.64
GTEx Pituitary 0 0.0000 1.60
GTEx Prostate 0 0.0000 1.63
GTEx Skin Not Sun Exposed Suprapubic 2 0.0813 1.67
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.59
GTEx Small Intestine Terminal Ileum 0 0.0000 1.79
GTEx Spleen 0 0.0000 1.67
GTEx Stomach 1 0.0688 1.69
GTEx Testis 3 0.0951 1.66
GTEx Thyroid 1 0.0250 1.58
GTEx Uterus 0 0.0000 1.74
GTEx Vagina 0 0.0000 1.65
GTEx Whole Blood 0 0.0000 1.50
METSIM Adipose 1 0.0217 1.49
NTR Blood 0 0.0000 1.51
ROSMAP Brain Pre-frontal Cortex 1 0.0228 1.56
YFS Blood 0 0.0000 1.47
CommonMind Brain Pre-frontal Cortex 1 0.0186 1.52
TCGA Breast Tumor 1 0.1304 1.58
TCGA Breast Normal 2 0.0475 1.45
TCGA Ovarian Tumor 0 0.0000 1.43
TCGA Prostate Tumor 1 0.0289 1.51