Hub : Traits :

Coronary Artery Disease (CAD)

45 significantly associated models · 17 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 109098737 110517617 2 1 7.0e-10 2.9e-10 1.0e+00 100 PSRC1
2 2 202952678 204788156 5 1 4.1e-11 1.8e-11 1.0e+00 100 NBEAL1
3 3 137189600 138819532 2 1 4.1e-08 3.3e-08 2.4e-01 96 MRAS
4 6 12020241 13990267 2 1 2.4e-13 2.5e-11 9.5e-01 100 RP1-257A7.5
5 8 35450876 36797280 1 1 1.4e-07 6.4e-02 2.8e-02 -40 MTND6P19
6 9 21303958 22819407 2 1 5.8e-21 2.3e-30 3.5e-11 67 CDKN2B
7 15 78360691 79802863 1 1 9.6e-11 2.9e-09 4.6e-01 98 ADAMTS7
8 17 46258510 47685050 1 1 2.9e-07 3.6e-06 2.4e-02 76 RP11-463M16.4
9 19 10793749 12191233 1 1 4.2e-08 9.7e-10 1.0e+00 100 EPOR

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (in father) 1.69 1 0 0.0 0.00 1.0e+00 NBEAL1
Alzheimer’s Disease (including proxy) 2.12 1 0 0.0 0.00 1.0e+00 NBEAL1
Breast Cancer 1.31 1 0 0.0 0.00 1.0e+00 CDKN2B
Age at First Birth 5.66 1 1 3.0 0.00 1.0e+00 MTND6P19
HDL Cholesterol 3.70 2 1 3.0 0.00 1.0e+00 MTND6P19 PSRC1
LDL Cholesterol 67.89 2 2 6.1 0.00 1.0e+00 EPOR PSRC1
Lupus 1.10 1 0 0.0 0.00 1.0e+00 RP11-463M16.4
Primary Biliary Cirrhosis 2.13 1 0 0.0 0.00 1.0e+00 EPOR
Type 2 Diabetes (T2D) 3.43 1 0 0.0 0.00 1.0e+00 CDKN2B
Blood Eosinophil Count 0.72 2 0 0.0 0.00 1.0e+00 EPOR NBEAL1
Blood Platelet Count 0.97 4 1 3.0 -0.02 9.8e-01 ADAMTS7 CDKN2B NBEAL1 RP11-463M16.4
Blood Red Count 0.51 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Blood White Count 0.98 3 0 0.0 0.00 1.0e+00 CDKN2B EPOR RP1-257A7.5
Heel T-Score 0.71 2 0 0.0 0.00 1.0e+00 MRAS PSRC1
BMI 1.61 4 1 3.0 -0.38 6.2e-01 MRAS NBEAL1 RP11-463M16.4 RP1-257A7.5
Height 1.51 5 4 12.1 -0.67 2.2e-01 EPOR MRAS NBEAL1 PSRC1 RP11-463M16.4
Waist Hip Ratio (WHR) 2.06 2 1 3.0 0.00 1.0e+00 ADAMTS7 MRAS
Systolic Blood Pressure 3.37 5 3 9.1 0.60 2.8e-01 EPOR MRAS NBEAL1 RP11-463M16.4 RP1-257A7.5
Smoking Status 3.05 2 0 0.0 0.00 1.0e+00 NBEAL1 RP11-463M16.4
Cardiovascular Disease 9.01 4 4 12.1 0.99 1.2e-02 EPOR MRAS PSRC1 RP11-463M16.4
Respiratory disease 2.38 1 1 3.0 0.00 1.0e+00 NBEAL1
Type 2 Diabetes (T2D) 2.87 2 0 0.0 0.00 1.0e+00 MRAS RP11-463M16.4
Lung FEV1/FVC ratio 1.13 2 1 3.0 0.00 1.0e+00 NBEAL1 PSRC1
Lung FVC 0.93 1 0 0.0 0.00 1.0e+00 NBEAL1
Neuroticism 1.73 2 0 0.0 0.00 1.0e+00 NBEAL1 RP1-257A7.5
Hair Pigment 0.50 5 1 3.0 0.04 9.5e-01 ADAMTS7 CDKN2B EPOR MRAS RP11-463M16.4
Tanning 0.31 1 0 0.0 0.00 1.0e+00 EPOR
Hand grip strength (left) 1.32 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Number of treatments/medications taken 4.32 2 1 3.0 0.00 1.0e+00 MRAS PSRC1
Average weekly spirits intake 1.90 1 0 0.0 0.00 1.0e+00 NBEAL1
Frequency of depressed mood in last 2 weeks 1.39 1 0 0.0 0.00 1.0e+00 NBEAL1
Other serious medical condition/disability diagnosed by doctor 1.36 1 0 0.0 0.00 1.0e+00 PSRC1
Systolic blood pressure, automated reading 2.55 4 1 3.0 -0.29 7.1e-01 EPOR MRAS RP11-463M16.4 RP1-257A7.5
Angina 21.43 6 3 9.1 -0.98 6.6e-04 ADAMTS7 CDKN2B NBEAL1 PSRC1 RP11-463M16.4 RP1-257A7.5
Medication for hormone replacement therapy 1.75 1 0 0.0 0.00 1.0e+00 NBEAL1
Medication: Metformin 2.39 1 0 0.0 0.00 1.0e+00 CDKN2B
Diabetes (father) 2.44 1 0 0.0 0.00 1.0e+00 RP11-463M16.4
Pack years adult smoking proportion 3.96 1 1 3.0 0.00 1.0e+00 ADAMTS7
Impedance of leg (right) 1.16 1 1 3.0 0.00 1.0e+00 RP11-463M16.4
Leg fat-free mass (left) 1.09 3 0 0.0 0.00 1.0e+00 EPOR MRAS PSRC1
Trunk fat percentage 1.41 2 0 0.0 0.00 1.0e+00 MRAS RP1-257A7.5
Hand grip strength (right) 1.36 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Townsend deprivation index at recruitment 1.98 1 0 0.0 0.00 1.0e+00 NBEAL1
Current tobacco smoking 3.18 1 0 0.0 0.00 1.0e+00 NBEAL1
Fed-up feelings 1.83 1 0 0.0 0.00 1.0e+00 NBEAL1
Taking other prescription medications 2.10 1 0 0.0 0.00 1.0e+00 MRAS
High blood pressure 3.98 3 2 6.1 0.00 1.0e+00 MRAS RP11-463M16.4 RP1-257A7.5
Diverticular disease/diverticulitis (self-reported) 1.33 1 0 0.0 0.00 1.0e+00 NBEAL1
Medication: Atenolol 4.93 2 0 0.0 0.00 1.0e+00 CDKN2B NBEAL1
Sitting height 1.28 2 2 6.1 0.00 1.0e+00 NBEAL1 RP11-463M16.4
Chronic bronchitis/emphysema (father) 2.51 1 0 0.0 0.00 1.0e+00 ADAMTS7
High blood pressure (mother) 3.69 3 0 0.0 0.00 1.0e+00 MRAS RP11-463M16.4 RP1-257A7.5
Body mass index (BMI) 1.39 2 0 0.0 0.00 1.0e+00 RP11-463M16.4 RP1-257A7.5
Impedance of leg (left) 1.22 1 1 3.0 0.00 1.0e+00 RP11-463M16.4
Leg predicted mass (left) 1.12 3 0 0.0 0.00 1.0e+00 EPOR MRAS PSRC1
Trunk fat mass 1.30 2 0 0.0 0.00 1.0e+00 MRAS RP1-257A7.5
Waist circumference 0.96 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Number of incorrect matches in round 1.43 1 0 0.0 0.00 1.0e+00 MRAS
Past tobacco smoking 2.30 1 0 0.0 0.00 1.0e+00 RP11-463M16.4
Forced vital capacity (FVC) 1.37 2 0 0.0 0.00 1.0e+00 EPOR NBEAL1
Heart attack 19.27 5 3 9.1 -0.99 1.5e-03 CDKN2B MRAS NBEAL1 PSRC1 RP1-257A7.5
Allergy 1.05 1 0 0.0 0.00 1.0e+00 NBEAL1
Medication: Ramipril 3.43 1 0 0.0 0.00 1.0e+00 MRAS
Medication: Simvastatin 18.61 4 2 6.1 -0.95 4.6e-02 CDKN2B EPOR MRAS PSRC1
Illnesses of siblings 2.83 1 0 0.0 0.00 1.0e+00 RP11-463M16.4
Neuroticism score 1.33 1 0 0.0 0.00 1.0e+00 NBEAL1
Weight 1.24 3 0 0.0 0.00 1.0e+00 EPOR MRAS RP1-257A7.5
Impedance of arm (right) 1.18 2 0 0.0 0.00 1.0e+00 CDKN2B RP11-463M16.4
Arm fat percentage (right) 1.72 3 0 0.0 0.00 1.0e+00 MRAS NBEAL1 RP1-257A7.5
Trunk fat-free mass 1.34 2 2 6.1 0.00 1.0e+00 EPOR PSRC1
Hip circumference 1.38 2 0 0.0 0.00 1.0e+00 ADAMTS7 MRAS
Father's age at death 4.21 2 0 0.0 0.00 1.0e+00 CDKN2B PSRC1
Falls in the last year 1.42 1 0 0.0 0.00 1.0e+00 NBEAL1
Forced expiratory volume in 1-second (FEV1) 1.49 1 0 0.0 0.00 1.0e+00 EPOR
Asthma 1.83 1 0 0.0 0.00 1.0e+00 NBEAL1
Medication: Ibuprofen (e.g. Nurofen) 4.08 1 1 3.0 0.00 1.0e+00 RP1-257A7.5
Medication: Cholesterol lowering 23.95 3 2 6.1 0.00 1.0e+00 CDKN2B EPOR PSRC1
Lung cancer (father) 3.52 1 0 0.0 0.00 1.0e+00 ADAMTS7
Illnesses of mother 3.28 1 0 0.0 0.00 1.0e+00 CDKN2B
Forced expiratory volume in 1-second (FEV1), Best measure 1.66 1 0 0.0 0.00 1.0e+00 EPOR
Pulse wave Arterial Stiffness index 2.75 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Impedance of arm (left) 1.16 1 0 0.0 0.00 1.0e+00 RP11-463M16.4
Arm fat mass (right) 1.45 2 0 0.0 0.00 1.0e+00 MRAS RP1-257A7.5
Trunk predicted mass 1.33 2 2 6.1 0.00 1.0e+00 EPOR PSRC1
Standing height 1.42 4 2 6.1 0.67 3.3e-01 EPOR NBEAL1 PSRC1 RP11-463M16.4
Birth weight of first child 1.31 1 0 0.0 0.00 1.0e+00 EPOR
Peak expiratory flow (PEF) 0.81 1 0 0.0 0.00 1.0e+00 EPOR
Pulse wave reflection index 3.11 1 0 0.0 0.00 1.0e+00 NBEAL1
Medication: Paracetamol 3.80 2 1 3.0 0.00 1.0e+00 NBEAL1 RP1-257A7.5
Headache pain in last month 5.72 2 1 3.0 0.00 1.0e+00 NBEAL1 RP1-257A7.5
Medication for cholesterol, blood pressure or diabetes 9.13 3 2 6.1 0.00 1.0e+00 EPOR PSRC1 RP11-463M16.4
Glaucoma (self-reported) 5.22 1 1 3.0 0.00 1.0e+00 CDKN2B
Forced vital capacity (FVC), Best measure 1.66 2 0 0.0 0.00 1.0e+00 EPOR NBEAL1
Body fat percentage 1.56 3 0 0.0 0.00 1.0e+00 MRAS NBEAL1 RP1-257A7.5
Leg fat percentage (right) 1.48 2 0 0.0 0.00 1.0e+00 NBEAL1 RP1-257A7.5
Arm fat-free mass (right) 1.45 2 0 0.0 0.00 1.0e+00 EPOR PSRC1
Comparative body size at age 10 0.84 1 0 0.0 0.00 1.0e+00 RP11-463M16.4
Wheeze or whistling in the chest in last year 1.80 1 0 0.0 0.00 1.0e+00 NBEAL1
Pulse wave peak to peak time 2.84 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Qualifications: College or University degree 1.37 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Medication for pain relief, constipation, heartburn 3.16 2 0 0.0 0.00 1.0e+00 PSRC1 RP1-257A7.5
Medication: Blood pressure 3.99 1 1 3.0 0.00 1.0e+00 RP11-463M16.4
Angina (self-reported) 21.84 6 3 9.1 -0.98 8.4e-04 ADAMTS7 CDKN2B NBEAL1 PSRC1 RP11-463M16.4 RP1-257A7.5
Migraine (self-reported) 6.67 2 1 3.0 0.00 1.0e+00 NBEAL1 RP1-257A7.5
Medication: Ibuprofen 3.76 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Heart disease (mother) 9.40 3 1 3.0 0.00 1.0e+00 ADAMTS7 CDKN2B RP1-257A7.5
Whole body fat mass 1.36 2 0 0.0 0.00 1.0e+00 MRAS RP1-257A7.5
Leg fat mass (right) 1.25 2 0 0.0 0.00 1.0e+00 MRAS RP1-257A7.5
Arm predicted mass (right) 1.42 3 0 0.0 0.00 1.0e+00 EPOR MRAS PSRC1
Pulse rate, automated reading 1.35 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Alcohol intake frequency. 2.35 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Comparative height size at age 10 0.90 1 0 0.0 0.00 1.0e+00 PSRC1
Overall health rating 2.13 1 0 0.0 0.00 1.0e+00 RP11-463M16.4
Chest pain or discomfort 1.90 1 0 0.0 0.00 1.0e+00 CDKN2B
Medication: Aspirin 11.59 5 2 6.1 -0.99 1.7e-03 CDKN2B EPOR MRAS PSRC1 RP11-463M16.4
Knee pain experienced in last month 2.90 2 0 0.0 0.00 1.0e+00 NBEAL1 RP1-257A7.5
Hypertension (Self-reported) 3.97 3 2 6.1 0.00 1.0e+00 MRAS RP11-463M16.4 RP1-257A7.5
Illnesses of father: Heart disease 20.50 7 4 12.1 -0.99 2.5e-05 ADAMTS7 CDKN2B EPOR MRAS NBEAL1 PSRC1 RP1-257A7.5
Forced expiratory volume in 1-second (FEV1), predicted 1.70 1 0 0.0 0.00 1.0e+00 EPOR
Whole body fat-free mass 1.26 2 1 3.0 0.00 1.0e+00 EPOR PSRC1
Leg fat-free mass (right) 1.04 2 0 0.0 0.00 1.0e+00 EPOR PSRC1
Arm fat percentage (left) 1.59 3 0 0.0 0.00 1.0e+00 MRAS NBEAL1 RP1-257A7.5
Loneliness, isolation 1.57 1 0 0.0 0.00 1.0e+00 NBEAL1
Long-standing illness, disability or infirmity 2.97 2 0 0.0 0.00 1.0e+00 CDKN2B MRAS
Diabetes diagnosed by doctor 2.14 1 0 0.0 0.00 1.0e+00 MRAS
Medication for cholesterol 5.69 2 1 3.0 0.00 1.0e+00 MRAS PSRC1
Back pain experienced in last month 1.50 1 0 0.0 0.00 1.0e+00 MTND6P19
Breast cancer (self-reported) 3.41 1 0 0.0 0.00 1.0e+00 CDKN2B
Asthma (self-reported) 1.67 1 0 0.0 0.00 1.0e+00 NBEAL1
Medication: Aspirin 11.85 5 2 6.1 -0.99 1.4e-03 CDKN2B EPOR MRAS PSRC1 RP11-463M16.4
Illnesses of father: None of the above (group 1) 5.33 1 1 3.0 0.00 1.0e+00 CDKN2B
Smoking status: Current 3.12 1 0 0.0 0.00 1.0e+00 NBEAL1
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.06 1 0 0.0 0.00 1.0e+00 ADAMTS7
Whole body water mass 1.22 2 0 0.0 0.00 1.0e+00 EPOR PSRC1
Leg predicted mass (right) 1.04 2 0 0.0 0.00 1.0e+00 EPOR PSRC1
Arm fat mass (left) 1.39 2 0 0.0 0.00 1.0e+00 MRAS RP1-257A7.5
Number of self-reported non-cancer illnesses 3.89 2 0 0.0 0.00 1.0e+00 NBEAL1 PSRC1
Miserableness 1.38 1 0 0.0 0.00 1.0e+00 NBEAL1
Guilty feelings 1.99 1 0 0.0 0.00 1.0e+00 NBEAL1
Eye problems/disorders: Glaucoma 7.69 1 1 3.0 0.00 1.0e+00 CDKN2B
Medication: Blood pressure 3.30 2 0 0.0 0.00 1.0e+00 ADAMTS7 MRAS
High cholesterol (Self-reported) 32.56 3 2 6.1 0.00 1.0e+00 EPOR NBEAL1 PSRC1
Medication: Bendroflumethiazide 3.87 2 0 0.0 0.00 1.0e+00 ADAMTS7 RP11-463M16.4
Medication: Paracetamol 2.41 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Medication: Atorvastatin 18.07 3 3 9.1 0.00 1.0e+00 CDKN2B EPOR PSRC1
Ever smoked 2.15 1 0 0.0 0.00 1.0e+00 NBEAL1
Basal metabolic rate 1.20 2 0 0.0 0.00 1.0e+00 EPOR PSRC1
Leg fat percentage (left) 1.43 2 0 0.0 0.00 1.0e+00 NBEAL1 RP1-257A7.5
Arm fat-free mass (left) 1.27 2 0 0.0 0.00 1.0e+00 EPOR PSRC1
Diastolic blood pressure, automated reading 4.31 5 1 3.0 0.57 3.2e-01 ADAMTS7 CDKN2B MRAS NBEAL1 RP11-463M16.4
Unable to work because of sickness or disability 2.13 1 0 0.0 0.00 1.0e+00 MTND6P19
Vascular/heart problems diagnosed by doctor 4.51 3 2 6.1 0.00 1.0e+00 CDKN2B MRAS RP11-463M16.4
Cholesterol lowering medication 18.98 5 2 6.1 -0.62 2.6e-01 CDKN2B EPOR MRAS NBEAL1 PSRC1
Pain experienced in last month 3.00 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Basal cell carcinoma (self-reported) 3.03 1 0 0.0 0.00 1.0e+00 CDKN2B
Heart attack/myocardial infarction (self-reported) 19.58 5 3 9.1 -0.99 2.0e-03 CDKN2B MRAS NBEAL1 PSRC1 RP1-257A7.5
Heart disease (siblings) 6.64 4 0 0.0 -0.98 1.6e-02 ADAMTS7 CDKN2B PSRC1 RP1-257A7.5
Pack years of smoking 3.57 1 1 3.0 0.00 1.0e+00 ADAMTS7
Impedance of whole body 1.23 2 1 3.0 0.00 1.0e+00 PSRC1 RP11-463M16.4
Leg fat mass (left) 1.24 2 0 0.0 0.00 1.0e+00 MRAS RP1-257A7.5
Arm predicted mass (left) 1.36 2 1 3.0 0.00 1.0e+00 EPOR PSRC1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 3 0.0965 1.38
GTEx Adipose Visceral Omentum 1 0.0547 1.46
GTEx Adrenal Gland 0 0.0000 1.37
GTEx Artery Aorta 4 0.1513 1.50
GTEx Artery Coronary 3 0.2799 1.49
GTEx Artery Tibial 4 0.1192 1.43
GTEx Brain Caudate basal ganglia 0 0.0000 1.38
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.31
GTEx Brain Cerebellum 0 0.0000 1.33
GTEx Brain Cortex 0 0.0000 1.37
GTEx Brain Frontal Cortex BA9 1 0.1200 1.47
GTEx Brain Hippocampus 0 0.0000 1.24
GTEx Brain Hypothalamus 0 0.0000 1.32
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.23
GTEx Brain Putamen basal ganglia 0 0.0000 1.48
GTEx Breast Mammary Tissue 0 0.0000 1.40
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.35
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.40
GTEx Cells EBV-transformed lymphocytes 1 0.0776 1.40
GTEx Cells Transformed fibroblasts 3 0.0793 1.38
GTEx Colon Sigmoid 1 0.0771 1.39
GTEx Colon Transverse 0 0.0000 1.37
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.43
GTEx Esophagus Mucosa 1 0.0337 1.36
GTEx Esophagus Muscularis 1 0.0347 1.42
GTEx Heart Atrial Appendage 0 0.0000 1.40
GTEx Heart Left Ventricle 0 0.0000 1.35
GTEx Liver 1 0.1534 1.47
GTEx Lung 0 0.0000 1.38
GTEx Muscle Skeletal 2 0.0775 1.38
GTEx Nerve Tibial 2 0.0520 1.38
GTEx Ovary 0 0.0000 1.39
GTEx Pancreas 0 0.0000 1.37
GTEx Pituitary 0 0.0000 1.31
GTEx Prostate 0 0.0000 1.35
GTEx Skin Not Sun Exposed Suprapubic 2 0.0900 1.41
GTEx Skin Sun Exposed Lower leg 1 0.0310 1.38
GTEx Small Intestine Terminal Ileum 0 0.0000 1.34
GTEx Spleen 0 0.0000 1.39
GTEx Stomach 0 0.0000 1.38
GTEx Testis 1 0.0351 1.38
GTEx Thyroid 1 0.0282 1.40
GTEx Uterus 0 0.0000 1.33
GTEx Vagina 0 0.0000 1.32
GTEx Whole Blood 1 0.0571 1.47
METSIM Adipose 2 0.0476 1.34
NTR Blood 1 0.0442 1.33
ROSMAP Brain Pre-frontal Cortex 2 0.0499 1.27
YFS Blood 0 0.0000 1.27
CommonMind Brain Pre-frontal Cortex 4 0.0805 1.34
TCGA Breast Tumor 0 0.0000 1.36
TCGA Breast Normal 0 0.0000 1.27
TCGA Ovarian Tumor 2 0.0729 1.22
TCGA Prostate Tumor 0 0.0000 1.27