Hub : Traits :

Sensitivity / hurt feelings

455 significantly associated models · 50 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 52981087 54492569 2 1 4.2e-09 1.1e-08 5.9e-01 99 LRP8
2 2 147993969 149475737 1 1 3.1e-07 3.9e-08 9.4e-03 78 ORC4
3 7 125383444 127590914 1 1 4.9e-11 4.3e-14 1.9e-06 60 GRM8
4 8 8092025 9669775 5 1 1.4e-09 6.6e-09 1.3e-02 82 FAM86B3P
5 8 10056664 11860845 6 1 7.6e-12 7.5e-11 1.1e-01 94 XKR6
6 9 33056378 34496024 1 1 7.2e-08 1.1e-07 4.2e-03 71 PRSS3
7 9 95502571 96898436 1 1 9.2e-09 1.7e-08 4.9e-01 98 RP11-165J3.6
8 9 97520168 98975128 1 1 6.1e-12 1.6e-11 2.3e-01 97 PTCH1
9 12 109133588 110729807 4 1 6.7e-10 7.0e-08 7.3e-02 89 MYO1H
10 15 90718541 92120170 1 1 3.8e-08 3.2e-08 1.0e+00 100 FURIN
11 17 17484654 18914778 1 1 8.3e-08 4.1e-06 4.5e-03 62 TOP3A
12 17 42413481 45796313 25 1 5.4e-23 1.6e-21 4.3e-01 99 PLEKHM1
13 19 18829733 20313262 1 1 8.3e-08 9.7e-07 9.0e-01 100 GATAD2A

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Verbal and Numeric Reasoning (VNR) 1.7 1 0 0.0 0.00 1.0e+00 PLEKHM1
Breast Cancer 4.6 4 2 6.1 0.39 6.1e-01 FURIN GATAD2A PLEKHM1 TOP3A
Ovarian Cancer 2.9 1 1 3.0 0.00 1.0e+00 PLEKHM1
HDL Cholesterol 2.4 1 1 3.0 0.00 1.0e+00 MYO1H
Lupus 3.8 2 0 0.0 0.00 1.0e+00 FAM86B3P XKR6
Neuroticism 11.0 3 3 9.1 0.00 1.0e+00 FAM86B3P PLEKHM1 XKR6
Primary Biliary Cirrhosis 2.0 1 0 0.0 0.00 1.0e+00 PLEKHM1
Schizophrenia 5.1 3 2 6.1 0.00 1.0e+00 FAM86B3P FURIN GATAD2A
Triglycerides 2.9 1 0 0.0 0.00 1.0e+00 GATAD2A
Blood Eosinophil Count 3.0 5 5 15.2 0.02 9.8e-01 GATAD2A MYO1H ORC4 PLEKHM1 TOP3A
Blood Platelet Count 1.7 2 1 3.0 0.00 1.0e+00 GATAD2A TOP3A
Blood Red Count 3.5 1 1 3.0 0.00 1.0e+00 PLEKHM1
Blood White Count 1.4 4 2 6.1 -0.01 9.9e-01 FURIN MYO1H PLEKHM1 PTCH1
Heel T-Score 1.4 1 1 3.0 0.00 1.0e+00 PLEKHM1
Height 1.4 5 4 12.1 -0.53 3.6e-01 FURIN PLEKHM1 PTCH1 RP11-165J3.6 TOP3A
Waist Hip Ratio (WHR) 1.8 1 1 3.0 0.00 1.0e+00 PLEKHM1
Systolic Blood Pressure 4.4 4 3 9.1 0.52 4.8e-01 FURIN LRP8 PLEKHM1 TOP3A
Cardiovascular Disease 2.3 2 1 3.0 0.00 1.0e+00 FURIN TOP3A
Hypothyroidism (self reported) 1.4 1 0 0.0 0.00 1.0e+00 LRP8
Lung FEV1/FVC ratio 2.7 2 1 3.0 0.00 1.0e+00 PLEKHM1 PTCH1
Lung FVC 5.0 2 2 6.1 0.00 1.0e+00 PLEKHM1 PTCH1
Neuroticism 12.3 8 6 18.2 -0.99 3.3e-06 FURIN GRM8 MYO1H ORC4 PLEKHM1 PTCH1 RP11-165J3.6 TOP3A
Hair Pigment 0.1 1 0 0.0 0.00 1.0e+00 FURIN
Hand grip strength (left) 2.1 1 1 3.0 0.00 1.0e+00 PLEKHM1
Frequency of depressed mood in last 2 weeks 5.9 2 0 0.0 0.00 1.0e+00 PLEKHM1 RP11-165J3.6
Hearing difficulty/problems: Yes 3.1 1 0 0.0 0.00 1.0e+00 MYO1H
Relative age of first facial hair 4.0 1 1 3.0 0.00 1.0e+00 PLEKHM1
Systolic blood pressure, automated reading 5.3 4 4 12.1 -0.93 6.7e-02 FAM86B3P FURIN PLEKHM1 XKR6
Angina 2.5 1 1 3.0 0.00 1.0e+00 FURIN
Impedance of leg (right) 4.2 6 4 12.1 0.21 6.9e-01 FAM86B3P FURIN GATAD2A PLEKHM1 PTCH1 XKR6
Leg fat-free mass (left) 2.3 5 3 9.1 -0.23 7.1e-01 FAM86B3P FURIN GATAD2A PTCH1 XKR6
Trunk fat percentage 1.2 1 1 3.0 0.00 1.0e+00 PLEKHM1
Hand grip strength (right) 1.9 1 1 3.0 0.00 1.0e+00 PLEKHM1
Fed-up feelings 7.0 4 3 9.1 0.98 1.6e-02 FAM86B3P ORC4 PLEKHM1 XKR6
Relative age voice broke 3.0 1 1 3.0 0.00 1.0e+00 PLEKHM1
Taking other prescription medications 2.6 1 0 0.0 0.00 1.0e+00 GATAD2A
Age when periods started (menarche) 1.9 1 0 0.0 0.00 1.0e+00 PLEKHM1
Heel bone mineral density (BMD) T-score, automated (left) 5.8 2 2 6.1 0.00 1.0e+00 FAM86B3P XKR6
High blood pressure 4.9 4 3 9.1 -0.65 3.5e-01 FAM86B3P FURIN TOP3A XKR6
Medication: Atenolol 2.6 1 0 0.0 0.00 1.0e+00 FURIN
Medication: Levothyroxine sodium 3.4 2 0 0.0 0.00 1.0e+00 FAM86B3P XKR6
Sitting height 3.2 2 2 6.1 0.00 1.0e+00 PLEKHM1 PTCH1
High blood pressure (mother) 3.1 1 1 3.0 0.00 1.0e+00 FURIN
Body mass index (BMI) 2.5 2 2 6.1 0.00 1.0e+00 FAM86B3P XKR6
Impedance of leg (left) 4.2 6 4 12.1 0.22 6.8e-01 FAM86B3P FURIN GATAD2A PLEKHM1 PTCH1 XKR6
Leg predicted mass (left) 2.3 5 3 9.1 -0.24 7.0e-01 FAM86B3P FURIN GATAD2A PTCH1 XKR6
Trunk fat mass 1.2 2 0 0.0 0.00 1.0e+00 PLEKHM1 XKR6
Number of incorrect matches in round 2.9 1 1 3.0 0.00 1.0e+00 FURIN
Past tobacco smoking 2.4 1 0 0.0 0.00 1.0e+00 GRM8
Nervous feelings 10.5 5 3 9.1 0.95 1.2e-02 FAM86B3P MYO1H ORC4 PLEKHM1 XKR6
Frequency of tenseness / restlessness in last 2 weeks 6.6 3 1 3.0 0.00 1.0e+00 PLEKHM1 RP11-165J3.6 TOP3A
Hearing difficulty/problems with background noise 3.1 1 0 0.0 0.00 1.0e+00 PLEKHM1
Hair/balding pattern: Pattern 2 3.1 1 1 3.0 0.00 1.0e+00 PLEKHM1
Forced vital capacity (FVC) 4.9 2 2 6.1 0.00 1.0e+00 PLEKHM1 PTCH1
Heel bone mineral density (BMD) T-score, automated (right) 6.1 3 2 6.1 0.00 1.0e+00 FAM86B3P PLEKHM1 XKR6
Ever unenthusiastic/disinterested for a whole week 2.7 1 0 0.0 0.00 1.0e+00 PLEKHM1
Mouth/teeth dental problems 4.4 2 0 0.0 0.00 1.0e+00 MYO1H PLEKHM1
Heart attack 1.8 1 0 0.0 0.00 1.0e+00 FURIN
Allergy 1.9 1 0 0.0 0.00 1.0e+00 FURIN
Fluid intelligence score 1.6 1 0 0.0 0.00 1.0e+00 PLEKHM1
Neuroticism score 16.9 9 8 24.2 0.98 6.2e-06 FAM86B3P GRM8 MYO1H ORC4 PLEKHM1 PTCH1 RP11-165J3.6 TOP3A XKR6
Weight 1.5 2 1 3.0 0.00 1.0e+00 FAM86B3P XKR6
Impedance of arm (right) 3.3 3 3 9.1 0.00 1.0e+00 FAM86B3P PLEKHM1 XKR6
Arm fat percentage (right) 1.7 2 1 3.0 0.00 1.0e+00 FAM86B3P XKR6
Trunk fat-free mass 1.6 3 1 3.0 0.00 1.0e+00 GATAD2A PTCH1 XKR6
Hip circumference 1.4 3 1 3.0 0.00 1.0e+00 FAM86B3P PTCH1 XKR6
Father's age at death 3.3 1 0 0.0 0.00 1.0e+00 XKR6
Worrier / anxious feelings 13.3 7 4 12.1 0.92 3.0e-03 FAM86B3P MYO1H ORC4 PLEKHM1 PTCH1 RP11-165J3.6 XKR6
Frequency of tiredness / lethargy in last 2 weeks 5.1 2 2 6.1 0.00 1.0e+00 MYO1H RP11-165J3.6
Hair/balding pattern: Pattern 3 5.4 1 1 3.0 0.00 1.0e+00 PLEKHM1
Number of live births 3.4 2 0 0.0 0.00 1.0e+00 PLEKHM1 TOP3A
Forced expiratory volume in 1-second (FEV1) 4.6 3 2 6.1 0.00 1.0e+00 FAM86B3P PLEKHM1 PTCH1
Qualifications: A levels/AS levels or equivalent 1.6 1 0 0.0 0.00 1.0e+00 PLEKHM1
Medication: Ibuprofen (e.g. Nurofen) 2.3 1 0 0.0 0.00 1.0e+00 PLEKHM1
Medication: Cholesterol lowering 2.9 1 0 0.0 0.00 1.0e+00 GATAD2A
Forced expiratory volume in 1-second (FEV1), Best measure 4.1 3 1 3.0 0.00 1.0e+00 FAM86B3P PLEKHM1 PTCH1
Impedance of arm (left) 3.1 3 3 9.1 0.00 1.0e+00 FAM86B3P PLEKHM1 XKR6
Arm fat mass (right) 1.8 2 2 6.1 0.00 1.0e+00 FAM86B3P XKR6
Trunk predicted mass 1.6 3 1 3.0 0.00 1.0e+00 GATAD2A PTCH1 XKR6
Standing height 1.5 5 2 6.1 0.56 3.2e-01 FAM86B3P PLEKHM1 PTCH1 RP11-165J3.6 TOP3A
Tense / 'highly strung' 9.5 7 3 9.1 0.95 1.2e-03 FAM86B3P LRP8 ORC4 PLEKHM1 PTCH1 RP11-165J3.6 XKR6
Seen doctor (GP) for nerves, anxiety, tension or depression 4.2 1 0 0.0 0.00 1.0e+00 PTCH1
Hair/balding pattern: Pattern 4 7.0 1 1 3.0 0.00 1.0e+00 PLEKHM1
Birth weight of first child 2.6 1 1 3.0 0.00 1.0e+00 FURIN
Peak expiratory flow (PEF) 4.2 3 2 6.1 0.00 1.0e+00 FAM86B3P PLEKHM1 XKR6
Mouth/teeth dental problems: Bleeding gums 3.2 1 0 0.0 0.00 1.0e+00 MYO1H
Medication: Paracetamol 3.6 1 1 3.0 0.00 1.0e+00 PLEKHM1
Headache pain in last month 5.2 1 1 3.0 0.00 1.0e+00 PLEKHM1
Medication for cholesterol, blood pressure or diabetes 2.9 1 0 0.0 0.00 1.0e+00 FURIN
Hypothyroidism/myxoedema (self-reported) 4.3 3 2 6.1 0.00 1.0e+00 FAM86B3P LRP8 XKR6
Birth weight 3.0 2 2 6.1 0.00 1.0e+00 FURIN PTCH1
Forced vital capacity (FVC), Best measure 4.6 2 2 6.1 0.00 1.0e+00 PLEKHM1 PTCH1
Leg fat percentage (right) 1.4 2 0 0.0 0.00 1.0e+00 FAM86B3P XKR6
Arm fat-free mass (right) 1.6 3 1 3.0 0.00 1.0e+00 FAM86B3P PTCH1 XKR6
Comparative body size at age 10 4.1 4 3 9.1 -0.99 5.0e-03 FAM86B3P GATAD2A RP11-165J3.6 XKR6
Worry too long after embarrassment 9.3 4 3 9.1 0.95 4.7e-02 FAM86B3P MYO1H PLEKHM1 XKR6
Seen a psychiatrist for nerves, anxiety, tension or depression 3.8 1 1 3.0 0.00 1.0e+00 LRP8
Wheeze or whistling in the chest in last year 2.2 1 0 0.0 0.00 1.0e+00 RP11-165J3.6
Age at first live birth 3.4 2 0 0.0 0.00 1.0e+00 GATAD2A PLEKHM1
Qualifications: College or University degree 2.1 2 1 3.0 0.00 1.0e+00 LRP8 PLEKHM1
Medication for pain relief, constipation, heartburn 2.6 2 1 3.0 0.00 1.0e+00 PLEKHM1 RP11-165J3.6
Medication: Blood pressure 3.8 3 0 0.0 0.00 1.0e+00 FURIN TOP3A XKR6
Angina (self-reported) 2.5 1 1 3.0 0.00 1.0e+00 FURIN
Medication: Ibuprofen 2.2 1 0 0.0 0.00 1.0e+00 PLEKHM1
Whole body fat mass 1.3 2 0 0.0 0.00 1.0e+00 FAM86B3P XKR6
Leg fat mass (right) 1.6 2 2 6.1 0.00 1.0e+00 FAM86B3P XKR6
Arm predicted mass (right) 1.7 3 1 3.0 0.00 1.0e+00 FAM86B3P PTCH1 XKR6
Alcohol intake frequency. 2.4 2 1 3.0 0.00 1.0e+00 PLEKHM1 TOP3A
Comparative height size at age 10 1.3 2 1 3.0 0.00 1.0e+00 PLEKHM1 PTCH1
Suffer from 'nerves' 6.9 3 2 6.1 0.00 1.0e+00 FAM86B3P PTCH1 XKR6
Overall health rating 3.1 2 0 0.0 0.00 1.0e+00 RP11-165J3.6 XKR6
Hypertension (Self-reported) 4.8 4 3 9.1 -0.66 3.4e-01 FAM86B3P FURIN TOP3A XKR6
Forced expiratory volume in 1-second (FEV1), predicted 2.0 2 0 0.0 0.00 1.0e+00 PTCH1 TOP3A
Whole body fat-free mass 1.9 4 2 6.1 -0.48 5.2e-01 FAM86B3P GATAD2A PTCH1 XKR6
Leg fat-free mass (right) 2.4 5 4 12.1 -0.21 7.3e-01 FAM86B3P FURIN GATAD2A PTCH1 XKR6
Arm fat percentage (left) 1.7 2 1 3.0 0.00 1.0e+00 FAM86B3P XKR6
Handedness (chirality/laterality): Left-handed 3.3 2 1 3.0 0.00 1.0e+00 FURIN PLEKHM1
Mood swings 8.3 4 2 6.1 1.00 4.0e-04 FAM86B3P PLEKHM1 RP11-165J3.6 XKR6
Loneliness, isolation 4.8 2 0 0.0 0.00 1.0e+00 ORC4 PLEKHM1
Mouth/teeth dental problems: Mouth ulcers 3.5 1 1 3.0 0.00 1.0e+00 PLEKHM1
Medication for cholesterol 3.1 1 0 0.0 0.00 1.0e+00 PLEKHM1
Medication: Aspirin 2.2 1 0 0.0 0.00 1.0e+00 FURIN
Illnesses of father: None of the above (group 1) 2.5 1 0 0.0 0.00 1.0e+00 FURIN
Smoking status: Current 2.4 1 0 0.0 0.00 1.0e+00 XKR6
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.4 1 1 3.0 0.00 1.0e+00 PLEKHM1
Whole body water mass 1.9 4 2 6.1 -0.48 5.2e-01 FAM86B3P GATAD2A PTCH1 XKR6
Leg predicted mass (right) 2.4 5 4 12.1 -0.21 7.3e-01 FAM86B3P FURIN GATAD2A PTCH1 XKR6
Arm fat mass (left) 1.8 2 2 6.1 0.00 1.0e+00 FAM86B3P XKR6
Number of self-reported non-cancer illnesses 2.0 1 0 0.0 0.00 1.0e+00 TOP3A
Average weekly champagne plus white wine intake 2.9 1 0 0.0 0.00 1.0e+00 LRP8
Miserableness 8.2 5 4 12.1 0.99 9.2e-04 FAM86B3P ORC4 PLEKHM1 RP11-165J3.6 XKR6
Guilty feelings 7.2 4 1 3.0 0.99 7.2e-03 FAM86B3P PLEKHM1 PTCH1 XKR6
Medication: Blood pressure 5.4 4 3 9.1 -0.94 6.0e-02 FAM86B3P FURIN PLEKHM1 XKR6
High cholesterol (Self-reported) 2.0 1 1 3.0 0.00 1.0e+00 GATAD2A
Medication: Bendroflumethiazide 4.6 3 1 3.0 0.00 1.0e+00 FAM86B3P FURIN XKR6
Medication: Paracetamol 3.1 1 1 3.0 0.00 1.0e+00 PLEKHM1
Ever smoked 2.5 1 0 0.0 0.00 1.0e+00 LRP8
Basal metabolic rate 1.8 4 2 6.1 -0.52 4.8e-01 FAM86B3P GATAD2A PTCH1 XKR6
Leg fat percentage (left) 1.4 2 0 0.0 0.00 1.0e+00 FAM86B3P XKR6
Arm fat-free mass (left) 1.5 3 1 3.0 0.00 1.0e+00 FAM86B3P PTCH1 XKR6
Number of operations (self-reported) 3.1 1 0 0.0 0.00 1.0e+00 FURIN
Average weekly beer plus cider intake 2.3 1 0 0.0 0.00 1.0e+00 XKR6
Irritability 10.2 4 3 9.1 0.95 5.2e-02 FAM86B3P ORC4 PLEKHM1 XKR6
Fractured/broken bones in last 5 years 1.8 1 0 0.0 0.00 1.0e+00 PLEKHM1
Diastolic blood pressure, automated reading 3.6 3 3 9.1 0.00 1.0e+00 FAM86B3P FURIN XKR6
Ever depressed for a whole week 2.7 1 0 0.0 0.00 1.0e+00 PLEKHM1
Myopia 2.6 1 0 0.0 0.00 1.0e+00 GATAD2A
Vascular/heart problems diagnosed by doctor 4.7 4 2 6.1 0.64 3.6e-01 FAM86B3P FURIN TOP3A XKR6
Pain experienced in last month 2.9 2 0 0.0 0.00 1.0e+00 MYO1H PLEKHM1
Heart attack/myocardial infarction (self-reported) 1.6 1 0 0.0 0.00 1.0e+00 FURIN
Impedance of whole body 3.9 4 4 12.1 0.44 5.6e-01 FAM86B3P GATAD2A PLEKHM1 XKR6
Leg fat mass (left) 1.6 2 2 6.1 0.00 1.0e+00 FAM86B3P XKR6
Arm predicted mass (left) 1.6 3 2 6.1 0.00 1.0e+00 FAM86B3P PTCH1 XKR6

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 9 0.2578 1.66
GTEx Adipose Visceral Omentum 11 0.5403 1.81
GTEx Adrenal Gland 9 0.6177 1.83
GTEx Artery Aorta 14 0.4703 1.89
GTEx Artery Coronary 10 0.8453 2.18
GTEx Artery Tibial 8 0.2127 1.68
GTEx Brain Caudate basal ganglia 4 0.4348 1.91
GTEx Brain Cerebellar Hemisphere 9 0.6044 1.99
GTEx Brain Cerebellum 7 0.3532 1.86
GTEx Brain Cortex 7 0.6763 2.10
GTEx Brain Frontal Cortex BA9 6 0.6494 2.06
GTEx Brain Hippocampus 4 0.7634 2.14
GTEx Brain Hypothalamus 4 0.6780 2.08
GTEx Brain Nucleus accumbens basal ganglia 7 0.8092 2.08
GTEx Brain Putamen basal ganglia 5 0.8013 2.10
GTEx Breast Mammary Tissue 11 0.5572 1.84
GTEx Breast Mammary Tissue (Male) 7 0.5868 2.01
GTEx Breast Mammary Tissue (Female) 13 0.7908 1.86
GTEx Cells EBV-transformed lymphocytes 12 0.8433 2.04
GTEx Cells Transformed fibroblasts 11 0.2620 1.70
GTEx Colon Sigmoid 10 0.6840 1.90
GTEx Colon Transverse 13 0.6298 1.88
GTEx Esophagus Gastroesophageal Junction 9 0.6228 2.04
GTEx Esophagus Mucosa 15 0.4518 1.76
GTEx Esophagus Muscularis 14 0.4332 1.87
GTEx Heart Atrial Appendage 9 0.5700 1.89
GTEx Heart Left Ventricle 10 0.6536 1.98
GTEx Liver 5 0.6974 2.04
GTEx Lung 13 0.4525 1.81
GTEx Muscle Skeletal 11 0.3806 1.81
GTEx Nerve Tibial 10 0.2314 1.67
GTEx Ovary 8 0.8811 2.09
GTEx Pancreas 11 0.6740 1.97
GTEx Pituitary 7 0.6278 1.94
GTEx Prostate 6 0.7186 1.92
GTEx Skin Not Sun Exposed Suprapubic 12 0.4880 1.80
GTEx Skin Sun Exposed Lower leg 12 0.3297 1.77
GTEx Small Intestine Terminal Ileum 6 1.3015 2.30
GTEx Spleen 10 0.7087 1.91
GTEx Stomach 8 0.5502 1.95
GTEx Testis 11 0.3487 1.81
GTEx Thyroid 14 0.3501 1.77
GTEx Uterus 8 1.4109 2.42
GTEx Vagina 6 0.9449 2.15
GTEx Whole Blood 8 0.4014 1.73
METSIM Adipose 1 0.0217 1.47
NTR Blood 4 0.1665 1.68
ROSMAP Brain Pre-frontal Cortex 8 0.1822 1.62
YFS Blood 2 0.0433 1.47
CommonMind Brain Pre-frontal Cortex 8 0.1488 1.61
TCGA Breast Tumor 3 0.3911 1.72
TCGA Breast Normal 3 0.0713 1.46
TCGA Ovarian Tumor 7 0.2396 1.62
TCGA Prostate Tumor 5 0.1446 1.56