TWAS hub - GRM8

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1610	0.0340	2.4e-12	0.114	0.143	0.152	0.157	0.139	9.6e-14	4.9e-17	5.0e-18	1.2e-18	1.4e-16
2	ROSMAP	Brain Pre-frontal Cortex	0.1963	0.0391	5.6e-17	0.201	0.147	0.197	0.186	0.197	2.9e-25	1.7e-18	9.0e-25	2.2e-23	9.6e-25
3	TCGA	Breast Invasive Carcinoma	0.0490	0.0192	1.3e-03	0.023	0.019	0.018	NA	0.016	1.1e-05	6.9e-05	1.1e-04	NA	2.1e-04
4	TCGA	Brain Lower Grade Glioma	0.0758	0.0341	9.2e-03	0.003	0.015	0.018	NA	0.012	1.4e-01	7.4e-03	3.4e-03	NA	1.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Sensitivity / hurt feelings	9.6	16.4	43.2	3.4	6.6	-3.4	0.1
Neuroticism	7.0	17.0	35.8	4.4	6.0	-3.5	-0.7
Neuroticism score	6.2	13.0	26.5	3.8	5.2	-3.3	-0.6
Neuroticism (Nagel 2018)	5.9	13.9	26.4	3.7	5.1	-3.8	-1.0
Depressed Affect (Nagel 2018)	4.9	10.4	21.6	2.1	4.7	-3.9	-0.9
Supplements: Glucosamine	4.6	6.0	10.4	-3.2	-1.0	-1.5	-3.2
Past tobacco smoking	3.7	6.9	15.1	-2.3	-3.9	1.7	2.0
Reason for reducing amount of alcohol drunk: Health precaution	3.7	4.3	10.6	3.3	2.5	0.3	0.5
Mood swings	3.6	6.6	14.9	2.0	3.9	-2.6	-0.5
Miserableness	3.6	6.2	12.3	3.3	3.5	-1.3	0.3
Worry too long after embarrassment	3.5	5.8	11.1	3.2	3.3	-1.2	-0.7
Depression (Nagel 2018)	3.2	4.9	7.4	2.7	2.6	-2.2	0.7
Ever smoked	3.2	5.6	12.8	1.7	3.6	-1.9	-1.7
Supplements: Calcium	3.1	3.4	9.0	-1.5	1.2	-0.9	-3.0
Neuroticism (2016)	3.0	4.3	8.4	2.9	2.7	-1.2	-0.1
Frequency of depressed mood in last 2 weeks	2.9	4.1	6.5	1.9	2.5	-2.4	0.8
Nervous feelings	2.9	5.4	8.5	2.9	2.7	-2.4	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	2.9	4.5	12.7	1.4	3.6	-1.7	-0.7
Average weekly red wine intake	2.9	4.3	8.0	-2.5	-0.4	-2.8	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.8	3.3	7.6	2.8	1.5	0.2	1.8
Fed-up feelings	2.7	4.8	11.0	1.1	2.7	-3.3	-0.0
Tinnitus: Yes, but not now, but have in the past	2.7	2.9	5.8	2.4	2.3	0.4	-0.7
Guilty feelings	2.7	4.1	8.7	2.3	3.0	-1.6	-0.2
Worry (Nagel 2018)	2.6	5.5	11.5	3.4	2.5	-2.0	-0.1
Smoking status: Previous	2.6	3.8	9.2	2.0	3.0	-0.9	-1.1
Worrier / anxious feelings	2.5	4.7	10.9	1.9	3.3	-2.1	0.4
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.5	6.7	2.6	1.1	-0.2	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.3	3.1	7.1	2.7	2.0	-0.9	0.7
Falls in the last year	2.2	2.9	7.2	2.0	2.7	0.3	0.4
Eye problems/disorders: Glaucoma	2.1	2.4	5.1	2.1	-0.1	2.3	-0.3
Smoking Status	2.0	4.8	9.3	0.9	3.0	-2.4	-1.8
Qualifications: None of the above	2.0	4.3	12.4	0.5	3.5	-1.8	-1.1
Depression (self-reported)	2.0	2.3	6.0	0.7	2.5	-0.9	-1.4
Suffer from ‘nerves’	2.0	3.2	6.5	2.6	2.1	-1.4	0.0
Leg pain on walking	2.0	2.5	8.9	0.9	3.0	-0.5	-0.2
Qualifications: nursing, teaching	2.0	3.1	6.6	-0.2	-2.6	2.4	0.4
Verbal and Numeric Reasoning (VNR)	1.9	4.5	8.3	-2.9	-2.6	1.6	0.7
Wheeze or whistling in the chest in last year	1.9	3.4	7.4	1.1	2.2	-2.7	-0.3
Loneliness, isolation	1.9	2.6	4.3	2.1	2.0	-1.2	0.6
Medication: Paracetamol	1.9	2.9	4.7	-1.4	2.2	-2.2	-0.4
Hearing difficulty/problems with background noise	1.8	2.8	6.9	2.6	2.1	0.2	0.3
Glaucoma (self-reported)	1.8	2.2	5.5	2.4	0.3	1.7	-0.1
Neck or shoulder pain in last month	1.8	2.6	7.1	1.2	2.7	-1.4	0.1
Pulse rate, automated reading	1.8	5.7	13.5	1.4	0.5	2.7	3.7
Illnesses of father: None of the above (group 1)	1.8	2.2	3.6	-1.7	-1.9	1.1	1.1
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.7	4.6	1.9	2.1	-1.6	0.3
Qualifications: A levels/AS levels or equivalent	1.7	3.7	7.6	-1.9	-2.8	1.7	0.9
Medication: Paracetamol	1.7	2.7	3.9	-2.0	1.8	-1.9	-0.5
Financial situation satisfaction	1.7	2.1	3.9	1.4	2.0	1.6	0.5
Fluid intelligence score	1.6	3.3	7.8	-2.8	-1.9	0.9	0.8
Pulse wave reflection index	1.6	1.9	5.3	0.2	-0.3	-1.5	-2.3
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	7.8	-2.8	-1.3	-0.1	-0.7
Eye problems/disorders: Cataract	1.6	1.8	4.1	1.3	1.1	-0.6	-2.0
Medication: Gliclazide	1.6	1.8	4.6	1.1	-0.1	2.1	1.1
HbA1C	1.5	1.7	4.2	1.1	-0.3	1.1	2.0
Number of live births	1.5	2.1	3.5	1.3	1.9	-1.5	-0.9
Number of full brothers	1.5	1.8	3.3	1.0	1.8	-1.5	-0.9
Alcohol intake frequency.	1.5	3.5	6.5	2.0	-0.4	1.8	2.5
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	4.0	1.8	0.0	-0.2	2.0
Mean Putamen Volume	1.4	1.6	3.9	-0.3	2.0	-1.5	0.5
Fasting Glucose	1.4	1.7	5.5	-0.4	0.1	1.1	2.3
Multivitamins +/- minerals	1.4	1.8	2.6	1.5	1.6	-0.0	-1.4
Medication: Atenolol	1.4	1.8	2.2	-1.4	-0.8	-1.5	-1.5
Health satisfaction	1.4	1.8	6.9	0.5	2.6	-0.0	0.1
Migraine (self-reported)	1.4	1.7	4.0	0.0	2.0	-1.3	1.0
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	6.0	-0.8	-2.4	-0.0	-0.2
Mother’s age at death	1.4	1.8	4.4	-1.2	-2.1	0.9	0.7
Irritability	1.4	2.4	3.3	1.6	1.8	-1.8	-0.8
Alcohol drinker status: Previous	1.4	1.6	3.6	1.9	0.7	-0.1	1.6
Major Depression (MDD)	1.3	1.6	3.7	-1.9	1.4	-0.8	0.0
Bipolar Disorder (2011)	1.3	1.3	4.2	2.1	0.1	-0.5	0.8
Relative age of first facial hair	1.3	2.7	4.3	-2.0	0.4	-1.6	-2.1
Ever highly irritable/argumentative for 2 days	1.3	1.6	3.1	0.0	-1.7	1.8	-0.6
Heart disease (mother)	1.3	1.6	4.3	2.1	0.2	1.2	0.7
Osteoporosis (self-reported)	1.3	1.6	5.8	-2.4	-0.7	-0.6	0.0
Intelligence (Savage-Jansen 2018)	1.2	3.6	6.5	-2.5	-1.7	2.0	1.0
Allergy or Eczema	1.2	3.1	8.5	1.9	2.9	-0.6	-0.1
Medication: Cholesterol lowering	1.2	1.8	4.5	1.0	0.3	2.1	1.3
Pulse wave Arterial Stiffness index	1.2	1.4	3.8	0.5	0.8	-0.9	-1.9
Tense / ‘highly strung’	1.2	2.0	4.4	2.1	1.5	-0.9	-0.7
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	3.8	-1.6	-0.3	-1.9	-1.2
Medication: Aspirin	1.2	1.6	4.3	0.2	2.1	-1.3	0.5
Back pain experienced in last month	1.2	1.7	2.8	0.6	1.1	-1.7	-1.6
Number of operations (self-reported)	1.2	1.8	5.0	1.3	2.2	0.2	-0.6
Risk taking	1.2	1.7	6.2	-0.3	0.6	2.5	-0.3
Alzheimer’s Disease (including proxy)	1.1	1.5	2.7	0.2	1.7	-1.5	1.0
Heart attack	1.1	1.4	3.8	0.6	1.9	1.2	0.1
Medication: Ramipril	1.1	1.4	3.8	1.9	1.2	-0.1	0.7
Pulse wave peak to peak time	1.1	1.3	3.0	-0.8	-0.8	0.9	1.7
Chest pain or discomfort	1.1	1.6	2.6	1.5	1.2	-0.2	1.6
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.6	0.8	1.9	1.2	0.1
Primary Biliary Cirrhosis	1.0	1.4	3.6	1.1	-0.9	-0.4	1.9
Ulcerative Colitis	1.0	1.4	4.4	-0.5	-2.1	-0.8	0.5
Average weekly fortified wine intake	1.0	1.1	1.9	-0.9	-1.4	1.0	-1.0
Maternal smoking around birth	1.0	1.4	3.9	0.7	0.3	1.1	2.0
Medication: Levothyroxine sodium	1.0	1.6	3.5	1.9	1.6	0.5	-0.3
High blood pressure (mother)	1.0	1.4	4.0	0.5	0.1	-1.2	-2.0
Number of incorrect matches in round	1.0	1.7	3.5	-1.6	-1.9	0.9	-0.1
Had other major operations	1.0	1.2	4.0	0.9	2.0	0.1	-0.1
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	1.9	1.4	0.8	1.4	1.1
Medication: Lansoprazole	1.0	1.2	3.7	0.7	1.9	0.6	0.4
Lung cancer (father)	1.0	1.2	3.3	-0.6	-1.8	0.4	1.0
Qualifications: College or University degree	1.0	3.2	5.0	-1.8	-2.2	1.4	1.6
Eye problems/disorders: None of the above	1.0	1.1	2.6	-0.7	-0.2	-1.1	1.6
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.9	1.7	0.2	-0.8	-1.2
Medication: Aspirin	1.0	1.3	3.4	0.4	1.9	-1.1	0.7
Leg fat percentage (left)	1.0	3.5	13.2	3.6	0.8	0.1	-0.3
Fractured/broken bones in last 5 years	1.0	1.3	4.5	-2.1	-0.9	0.3	-0.2
Alzheimer’s Disease (in father)	0.9	1.0	3.0	-0.3	0.9	-1.7	0.3
Number of treatments/medications taken	0.9	1.7	3.5	0.9	1.9	-0.5	1.5
Ever had hysterectomy (womb removed)	0.9	1.0	1.4	-1.2	0.9	-1.1	-0.8
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.8	-0.0	1.0	-1.7	-0.4
Father’s age at death	0.9	1.2	2.6	1.6	0.9	0.2	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	3.7	0.6	1.9	-1.4	0.0
Exposure to tobacco smoke at home	0.9	1.0	3.4	1.8	0.0	0.7	-0.4
Leg fat mass (right)	0.9	3.5	12.5	3.5	0.5	0.8	-0.7
Overall health rating	0.9	2.0	4.7	0.6	2.2	-1.6	0.4
Family relationship satisfaction	0.9	1.1	3.5	-0.3	0.6	-0.7	-1.9
Number of self-reported non-cancer illnesses	0.9	1.6	3.6	1.9	1.4	0.6	0.7
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.7	0.4	1.6	0.7	1.2
Average weekly beer plus cider intake	0.9	1.3	3.1	0.6	1.3	-1.8	-0.1
Leg fat mass (left)	0.9	3.6	13.1	3.6	0.7	0.7	-0.6
Alzheimer’s Disease (in mother)	0.8	1.0	2.2	0.7	1.1	-0.4	1.5
LDL Cholesterol	0.8	1.2	4.2	0.7	-0.4	2.0	0.3
Hand grip strength (left)	0.8	2.0	3.8	1.9	-2.0	0.1	0.8
Relative age voice broke	0.8	1.3	3.3	-0.5	1.1	-0.4	-1.8
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.2	1.2	0.5	0.2	1.5
Alcohol usually taken with meals	0.8	1.2	2.7	0.9	-0.8	0.9	-1.6
Allergy	0.8	1.7	4.8	-1.3	-2.2	0.1	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.7	1.2	1.3	-0.0	1.0
Length of working week for main job	0.8	0.9	2.0	-0.4	-1.2	1.4	-0.2
Breastfed as a baby	0.8	0.9	3.6	0.4	0.0	-0.2	-1.9
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	2.5	0.2	0.3	-1.6	1.3
Body fat percentage	0.8	3.0	10.5	3.2	1.0	0.5	0.2
Leg fat percentage (right)	0.8	2.7	10.7	3.3	0.3	0.2	-0.2
Medication: Ibuprofen	0.8	1.0	2.4	1.6	1.1	0.3	0.4
Medication: Omeprazole	0.8	1.0	2.6	1.0	0.3	-0.3	1.6
Whole body fat mass	0.8	3.4	11.8	3.4	0.8	0.8	-0.6
Long-standing illness, disability or infirmity	0.8	1.2	2.5	1.1	0.9	0.4	1.6
Breast cancer (self-reported)	0.8	0.9	2.3	0.5	-0.0	1.1	-1.5
Osteoarthritis (self-reported)	0.8	1.1	1.6	-1.2	-0.9	0.8	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	3.2	0.8	1.8	-1.8	-0.2
Medication: Bendroflumethiazide	0.8	1.3	3.8	1.9	-0.2	0.8	0.7
Respiratory disease	0.7	1.5	2.9	-0.2	1.0	-1.5	-1.7
Hearing difficulty/problems: Yes	0.7	1.0	1.9	0.0	1.2	-1.4	-1.0
Medication: Co-codamol	0.7	0.8	2.6	-0.7	1.6	0.3	-0.3
Severe depression (siblings)	0.7	0.7	1.7	1.0	0.2	0.4	1.3
Qualifications: CSEs or equivalent	0.7	1.0	1.4	1.1	0.6	-1.2	-0.9
Hayfever, allergic rhinitis or eczema	0.7	1.6	4.2	1.2	2.0	-0.1	-0.8
Body mass index (BMI)	0.7	3.1	10.8	3.3	0.9	0.4	-0.7
Alcohol intake versus 10 years previously	0.7	1.0	1.4	-0.6	1.2	0.9	1.2
Illnesses of mother	0.7	0.8	2.4	-1.6	0.3	-0.7	-0.5
Arm fat mass (right)	0.7	3.1	10.8	3.3	1.1	0.4	-0.4
Birth weight of first child	0.7	1.3	1.9	1.4	1.1	1.3	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	2.6	0.7	1.6	-0.8	-0.1
Number of full sisters	0.7	0.9	2.3	1.5	1.0	-0.0	0.5
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.2	0.4	0.3	1.5	-0.9
Illnesses of siblings: Diabetes	0.7	0.8	3.2	-0.1	-1.8	0.1	-0.3
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.6	0.7	0.2	-1.0	1.3
Illnesses of father: High blood pressure	0.7	0.9	3.3	1.8	-0.6	-0.1	-0.1
Prostate Cancer	0.6	0.9	1.9	1.4	-1.2	0.2	-0.5
Age at First Birth	0.6	0.9	3.1	0.6	-1.8	0.3	0.2
Body Mass Index (BMI) (2010)	0.6	0.9	1.4	1.2	-0.6	1.0	1.0
Chronotype (morning person)	0.6	1.4	2.3	0.8	1.1	1.5	1.2
Diabetes (father)	0.6	0.7	1.6	0.5	1.2	0.6	-0.9
Pack years adult smoking proportion	0.6	1.0	1.6	-1.0	-1.1	0.3	-1.2
Trunk fat mass	0.6	2.8	9.4	3.1	1.0	0.7	-0.3
Waist circumference	0.6	2.1	5.9	2.4	1.2	0.4	-0.8
Weight	0.6	2.9	9.3	3.0	0.6	0.8	-1.1
Time employed in main current job	0.6	0.7	1.5	1.2	1.1	0.5	-0.1
Happiness	0.6	0.8	1.6	0.1	1.3	-0.8	-0.9
Noisy workplace	0.6	0.7	1.2	0.7	1.1	1.1	-0.2
Impedance of arm (left)	0.6	2.9	7.3	-2.7	-0.2	-0.3	2.0
Exposure to tobacco smoke outside home	0.6	0.9	2.0	0.7	1.4	-0.3	-0.9
Medication: Allopurinol	0.6	0.8	1.5	-1.0	-0.8	-0.4	1.2
Arm predicted mass (right)	0.6	3.2	6.9	2.6	0.6	1.0	-2.2
Had major operations	0.6	0.7	1.7	-0.2	-1.0	-0.2	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.8	1.8	-0.1	-0.8	1.3	0.8
Smoking status: Current	0.6	0.9	1.7	0.8	1.3	-0.7	-0.8
Arm fat mass (left)	0.6	2.3	8.3	2.9	0.7	0.5	-0.5
Wears glasses or contact lenses	0.6	0.7	2.7	-1.6	-0.4	0.3	0.1
Tinnitus: Yes, now most or all of the time	0.6	0.6	1.7	-0.4	0.9	-1.3	-0.1
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.9	-1.0	1.4	-0.3	-0.3
Medication: Atorvastatin	0.6	0.8	0.9	0.8	-0.9	1.0	0.9
Arm fat-free mass (left)	0.6	2.9	6.7	2.6	0.5	0.6	-2.1
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.8	0.6	-1.3	0.8	0.3
Commuting to job workplace: Cycle	0.6	0.7	1.3	-0.5	-0.8	-0.9	-1.1
Arm predicted mass (left)	0.6	3.3	7.5	2.7	0.6	0.6	-2.2
Bipolar Disorder (2018)	0.5	0.8	1.4	0.7	-1.1	-0.2	1.2
Reaction Time	0.5	1.0	2.5	0.1	-1.6	0.6	1.1
Coronary Artery Disease (CAD)	0.5	0.6	0.9	-1.0	-0.5	-0.7	1.0
HDL Cholesterol	0.5	0.8	2.3	-0.8	-1.5	-0.6	0.0
Schizophrenia (2014)	0.5	1.2	3.5	1.9	-0.6	0.6	0.7
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.4	0.5	1.2	-0.5	-0.7
Vitamin and mineral supplements	0.5	0.7	2.2	-0.7	-1.5	0.3	0.2
Diabetes (mother)	0.5	0.7	1.8	-0.8	1.3	-0.7	-0.0
Trunk fat percentage	0.5	2.0	6.3	2.5	0.9	0.7	0.4
Taking other prescription medications	0.5	0.8	2.2	0.8	-0.3	1.5	0.4
Illnesses of siblings	0.5	0.7	1.8	0.4	1.4	-0.4	-0.8
Impedance of arm (right)	0.5	2.4	5.2	-2.3	-0.1	-0.3	2.0
Arm fat percentage (right)	0.5	2.1	7.5	2.7	0.9	0.0	0.4
Trunk fat-free mass	0.5	3.1	6.8	2.3	0.4	0.6	-2.6
Pulse rate	0.5	0.9	1.6	-0.1	-1.0	1.0	1.3
Trunk predicted mass	0.5	3.0	6.7	2.2	0.4	0.6	-2.6
Loud music exposure frequency	0.5	0.6	1.3	1.1	-0.5	0.4	0.7
Blood clot in the leg (DVT)	0.5	0.6	1.6	0.6	-0.6	1.3	0.2
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.6	0.7	0.6	-0.1	-1.3
Arm fat-free mass (right)	0.5	2.7	5.7	2.1	0.3	0.7	-2.4
Number of children fathered	0.5	0.6	2.2	-0.3	0.2	1.5	-0.1
Shortness of breath walking on level ground	0.5	0.6	1.1	0.9	1.1	0.6	0.5
Medication for pain relief, constipation, heartburn	0.5	0.9	1.7	-0.4	-1.3	0.8	-1.0
Commuting to job workplace: Public transport	0.5	0.6	2.3	0.1	-0.3	0.2	1.5
High cholesterol (Self-reported)	0.5	0.9	1.9	0.5	0.7	1.4	0.9
Medication: Lisinopril	0.5	0.7	1.9	0.1	-1.4	0.6	0.6
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.5	-1.6	-1.3	-0.2	-1.1
Pain experienced in last month	0.5	0.8	2.8	-0.4	-1.7	0.3	0.0
Pack years of smoking	0.5	0.8	1.4	-0.9	-0.9	0.2	-1.2
Bipolar Disorder or Schizophrenia	0.4	1.0	2.8	1.7	-0.9	-0.4	0.4
Crohns Disease (2017)	0.4	0.9	1.5	0.9	0.3	-1.0	-1.2
Ulcerative Colitis (UC)	0.4	0.7	2.5	0.5	-1.6	-0.1	0.1
Breast Cancer	0.4	0.9	1.4	0.7	0.7	-1.1	-1.2
Crohns Disease (2012)	0.4	0.7	1.4	-0.2	-0.1	-1.1	-1.2
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.7	0.8	0.6	-0.7	0.5
BMI	0.4	2.4	6.4	2.5	1.4	-1.1	-0.2
Hypothyroidism (self reported)	0.4	1.0	3.3	1.8	0.1	-0.2	-0.7
Lung FVC	0.4	2.2	4.6	1.7	2.1	-0.5	-1.0
Medication for hormone replacement therapy	0.4	0.4	1.4	0.4	-0.3	1.2	-0.0
Medication: Metformin	0.4	0.6	1.6	-0.2	0.1	0.8	-1.3
Age when periods started (menarche)	0.4	1.0	1.7	0.4	1.1	-0.9	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.0	-1.4	-1.0	-1.0	0.2
High blood pressure	0.4	1.0	2.4	1.6	1.0	0.2	0.9
Chronic bronchitis/emphysema (father)	0.4	0.4	1.2	0.3	1.1	-0.4	0.4
Had menopause	0.4	0.5	1.9	0.5	-0.1	-0.0	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.4	-1.6	-0.5	-1.0	-0.5
Hip circumference	0.4	1.7	3.5	1.9	0.9	-0.1	-1.5
Hair/balding pattern: Pattern 3	0.4	0.5	1.1	0.8	-0.2	0.6	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.0	-0.2	1.0	-0.9	-0.2
Peak expiratory flow (PEF)	0.4	0.9	1.9	0.8	0.3	1.4	1.0
Gout (self-reported)	0.4	0.6	1.4	-0.5	-0.4	-0.7	1.2
Medication: Amlodipine	0.4	0.6	1.2	-0.5	-1.1	1.0	0.0
Birth weight	0.4	0.8	1.2	1.1	0.9	-0.4	-1.0
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.2	-0.6	-0.4	1.1	-0.0
Comparative body size at age 10	0.4	1.0	1.8	-0.8	-0.4	1.3	-1.3
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.1	1.0	-0.1	0.3	-0.9
Medication: Seretide 50 evohaler	0.4	0.5	1.4	0.6	-0.5	-1.2	-0.0
Supplements: Vitamin C	0.4	0.5	1.2	-1.1	-0.1	0.9	-0.2
Knee pain experienced in last month	0.4	0.6	2.0	0.2	1.4	-0.0	0.7
Whole body fat-free mass	0.4	2.4	4.9	2.1	0.1	0.6	-2.2
Arm fat percentage (left)	0.4	1.7	6.2	2.5	0.7	0.1	0.4
Ever had bowel cancer screening	0.4	0.5	1.1	0.0	0.7	-1.1	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.2	-1.0	0.7	-1.1	0.1
Mineral and other dietary supplements	0.4	0.6	1.2	0.9	-1.1	-0.1	0.5
Whole body water mass	0.4	2.4	4.8	2.1	0.0	0.6	-2.2
Average weekly champagne plus white wine intake	0.4	0.6	1.5	-0.4	-1.2	0.7	0.4
Ever taken oral contraceptive pill	0.4	0.5	1.7	0.0	-0.0	0.3	1.3
Basal metabolic rate	0.4	2.5	5.5	2.3	0.1	0.7	-2.0
Heart disease (siblings)	0.4	0.5	1.1	-0.7	0.2	0.8	1.0
Schizophrenia (2018)	0.3	0.7	2.4	1.6	-0.2	-0.4	-0.4
Irritable Bowel Disease (IBD)	0.3	0.8	1.2	1.1	-0.8	-0.7	-0.9
Rheumatoid Arthritis	0.3	0.4	1.0	0.0	0.7	-1.0	0.4
Cardiovascular Disease	0.3	1.1	2.2	0.8	1.5	0.1	1.3
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.1	1.1	-0.4	0.4	0.0
Systolic blood pressure, automated reading	0.3	0.9	1.5	0.2	-1.1	-1.0	-1.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	0.8	0.1	0.6	0.2
Angina	0.3	0.4	1.3	1.2	0.3	0.1	0.6
Supplements: Zinc	0.3	0.4	0.8	0.6	-0.4	0.9	-0.2
Hand grip strength (right)	0.3	0.8	1.7	1.3	-1.1	0.5	-0.1
Serious illness, injury or assault to yourself	0.3	0.4	1.2	-0.5	1.1	-0.3	0.2
Hair/balding pattern: Pattern 2	0.3	0.4	1.3	1.1	0.2	-0.5	0.3
Financial difficulties in last 2 years	0.3	0.3	1.2	0.1	1.1	0.2	0.4
Mouth/teeth dental problems	0.3	0.5	1.5	1.2	0.6	0.1	-0.4
Pain all over the body in last month	0.3	0.3	0.9	-0.1	-0.1	-1.0	-0.6
Medication: Simvastatin	0.3	0.5	1.6	0.5	-0.0	1.3	0.2
Hair/balding pattern: Pattern 4	0.3	0.8	1.7	1.2	-0.2	1.3	-0.3
Headache pain in last month	0.3	0.5	1.6	0.4	0.5	0.1	1.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	0.9	1.0	0.7	-0.6	-0.9
High blood pressure (siblings)	0.3	0.4	0.9	0.2	-0.9	-0.6	-0.5
Age at first live birth	0.3	0.5	1.5	-0.3	-0.2	1.2	0.7
Emphysema/chronic bronchitis	0.3	0.3	0.9	0.0	0.9	-0.6	0.1
Medication: Blood pressure	0.3	0.5	1.5	1.2	0.5	0.5	-0.0
Angina (self-reported)	0.3	0.4	1.3	1.1	0.1	0.2	0.3
Mean time to correctly identify matches	0.3	0.5	1.5	-0.0	-1.2	0.6	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.6	-0.7	0.0	-0.8	0.6
Illnesses of father: Heart disease	0.3	0.4	1.2	0.4	-1.1	0.3	0.3
Friendships satisfaction	0.3	0.3	0.6	0.5	0.5	-0.4	-0.8
Commuting to job workplace: Walk	0.3	0.3	0.5	0.7	0.6	0.6	0.3
Asthma (self-reported)	0.3	0.5	1.4	0.0	0.6	-0.5	-1.2
Unable to work because of sickness or disability	0.3	0.4	1.0	-0.2	0.5	0.7	1.0
Cholesterol lowering medication	0.3	0.5	0.8	0.1	0.7	-0.9	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.9	0.6	-0.5	0.9	0.0
Impedance of whole body	0.3	1.6	3.5	-1.9	0.4	-0.1	1.6
Schizophrenia vs Biploar Disorder	0.2	0.3	0.5	0.7	0.7	-0.1	0.4
Ovarian Cancer	0.2	0.3	0.8	0.2	-0.5	0.4	0.9
Lupus	0.2	0.2	0.6	0.3	0.4	-0.3	-0.8
Blood White Count	0.2	1.4	3.1	1.8	1.6	0.2	0.3
Heel T-Score	0.2	1.9	6.6	-2.6	0.6	-0.4	0.6
Systolic Blood Pressure	0.2	0.8	2.1	0.6	-0.4	-1.5	-0.8
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.6	-0.8	-0.1	0.6	-0.5
Leg fat-free mass (left)	0.2	1.2	2.4	1.5	-0.5	0.5	-1.4
Townsend deprivation index at recruitment	0.2	0.3	0.7	-0.3	-0.6	0.9	0.2
Current tobacco smoking	0.2	0.4	0.6	0.5	0.7	-0.5	-0.7
Stomach or abdominal pain in last month	0.2	0.2	0.5	0.3	-0.0	-0.5	-0.7
Leg predicted mass (left)	0.2	1.1	2.2	1.5	-0.5	0.5	-1.3
Forced vital capacity (FVC)	0.2	0.9	2.8	0.4	0.6	-0.4	-1.7
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.7	-0.5	-0.2	0.1	-0.9
Diabetes (self-reported)	0.2	0.4	1.0	0.4	-0.5	1.0	-0.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.2	0.3	1.1	-0.9	-1.1
Mouth/teeth dental problems: Dentures	0.2	0.4	1.0	0.0	-0.7	1.0	-0.2
Asthma	0.2	0.4	0.7	-0.1	0.7	-0.5	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	0.9	0.9	0.9	-0.4	-0.4
Age at last live birth	0.2	0.3	1.0	-0.2	0.3	1.0	0.1
Hypertension (Self-reported)	0.2	0.6	1.7	1.3	0.5	0.1	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.0	0.7	-1.0	0.8	-0.0
Leg fat-free mass (right)	0.2	1.2	2.6	1.6	-0.5	0.5	-1.3
Medication for cholesterol	0.2	0.2	0.9	-0.9	-0.2	-0.2	0.1
Leg predicted mass (right)	0.2	1.2	2.6	1.6	-0.5	0.6	-1.3
Hearing aid user	0.2	0.3	0.7	-0.8	0.1	0.4	-0.4
Medication: Blood pressure	0.2	0.4	0.6	0.3	-0.7	-0.7	0.8
Alcohol drinker status: Never	0.2	0.2	0.4	0.5	-0.7	0.3	-0.2
Age started oral contraceptive pill	0.2	0.2	0.5	-0.3	0.5	-0.3	0.7
Ever depressed for a whole week	0.2	0.2	0.6	-0.2	-0.4	0.3	-0.8
Myopia	0.2	0.3	0.7	-0.8	-0.7	0.0	0.5
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	0.6	-0.2	0.4	0.4
Triglycerides	0.1	0.1	0.2	0.1	0.0	0.4	0.4
Blood Eosinophil Count	0.1	1.1	2.5	1.1	1.6	-0.6	0.3
Blood Platelet Count	0.1	0.7	1.4	1.1	0.3	-0.0	1.2
Height	0.1	1.6	3.1	-0.2	-1.8	1.6	-1.0
Waist Hip Ratio (WHR)	0.1	0.6	1.2	-0.2	1.1	-0.6	0.9
Lung FEV1/FVC ratio	0.1	0.7	1.5	1.2	1.0	0.1	0.5
Tanning	0.1	0.8	2.4	-0.5	1.6	0.2	-0.6
Average weekly spirits intake	0.1	0.1	0.3	0.2	0.3	0.5	-0.1
Impedance of leg (right)	0.1	0.4	0.8	-0.5	0.9	0.2	0.8
Impedance of leg (left)	0.1	0.5	1.6	-0.0	1.3	0.1	0.6
Prospective memory result	0.1	0.2	0.2	0.3	0.5	-0.2	-0.5
Standing height	0.1	0.7	1.7	-0.1	-0.3	1.1	-1.3
Forced vital capacity (FVC), Best measure	0.1	0.3	0.7	0.6	0.8	-0.1	-0.4
Comparative height size at age 10	0.1	0.4	0.9	-0.4	-0.9	0.4	0.6
Diabetes diagnosed by doctor	0.1	0.2	0.6	0.1	0.2	0.8	-0.3
Blood Red Count	0.0	0.5	1.6	0.2	-0.1	1.3	0.5
Hair Pigment	0.0	1.4	2.1	1.3	1.5	0.5	-1.1
Sitting height	0.0	0.3	0.6	-0.8	0.3	-0.3	-0.6
Diastolic blood pressure, automated reading	0.0	0.2	0.6	0.0	-0.8	0.1	0.0

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Trait associations