Hub : Genes

PRSS3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2120	0.0460	1.6e-14	0.122	0.144	0.161	0.160	0.153	1.2e-14	4.0e-17	3.8e-19	4.8e-19	3.6e-18
2	ROSMAP	Brain Pre-frontal Cortex	0.1575	0.0424	8.4e-14	0.053	0.120	0.134	0.129	0.136	2.1e-07	4.0e-15	7.1e-17	3.4e-16	3.9e-17
3	TCGA	Brain Lower Grade Glioma	0.0431	0.0248	1.7e-03	0.005	0.017	0.000	NA	0.005	7.1e-02	4.5e-03	2.9e-01	NA	8.6e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.1	1.7	2.5	-1.6	-1.5	-0.7
Bipolar Disorder or Schizophrenia	1.9	4.6	7.6	-2.8	-2.4	-0.5
Depressed Affect (Nagel 2018)	0.3	0.7	1.1	-1.1	-1.0	-0.1
Depression (Nagel 2018)	0.4	0.6	1.2	-0.4	0.6	1.1
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.2	0.4	-0.5	1.5
Neuroticism (Nagel 2018)	2.5	5.9	8.7	-3.0	-2.9	-0.7
Schizophrenia (2018)	1.4	3.0	5.2	-2.3	-1.9	-0.1
Schizophrenia vs Biploar Disorder	1.6	2.1	2.4	-1.3	-1.5	1.5
Worry (Nagel 2018)	3.9	8.1	14.2	-3.8	-3.2	0.4
Alzheimer’s Disease (in mother)	0.3	0.3	0.7	-0.3	0.3	0.8
Alzheimer’s Disease (in father)	0.4	0.4	1.0	0.2	0.4	-1.0
Alzheimer’s Disease (including proxy)	0.2	0.2	0.5	-0.7	0.2	0.4
Crohns Disease (2017)	0.6	1.4	2.2	-1.5	-1.4	0.3
Irritable Bowel Disease (IBD)	0.7	1.8	3.1	-1.8	-1.5	0.1
Ulcerative Colitis (UC)	0.5	0.9	2.0	-1.4	-0.8	-0.2
Major Depression (MDD)	0.2	0.3	0.5	-0.2	-0.5	0.7
Reaction Time	0.2	0.4	0.7	0.2	0.8	0.6
Verbal and Numeric Reasoning (VNR)	1.0	2.3	4.8	1.3	0.7	2.2
Breast Cancer	0.4	0.9	1.5	1.2	1.1	-0.0
Ovarian Cancer	1.4	1.9	3.8	-0.4	-1.3	-1.9
Prostate Cancer	4.3	6.1	9.6	1.9	2.2	3.1
Age at First Birth	0.0	0.0	0.1	-0.3	0.1	0.1
Bipolar Disorder (2011)	1.5	1.4	2.5	-1.6	-1.3	-0.3
Body Mass Index (BMI) (2010)	0.6	0.8	1.6	1.3	0.9	-0.3
Coronary Artery Disease (CAD)	0.3	0.3	0.6	0.7	0.5	-0.4
Crohns Disease (2012)	0.7	1.1	2.0	-1.4	-1.0	-0.4
Mean Putamen Volume	1.4	1.5	2.1	1.4	1.3	1.0
Fasting Glucose	1.0	1.2	3.2	0.6	-0.2	1.8
HbA1C	0.3	0.4	1.0	-0.3	-0.2	1.0
HDL Cholesterol	0.4	0.6	0.9	0.9	0.5	0.8
LDL Cholesterol	0.5	0.8	2.2	-0.0	1.5	-0.6
Lupus	2.4	3.7	4.9	-2.2	-2.2	-1.2
Neuroticism (2016)	2.2	3.1	5.2	-2.3	-1.7	-1.1
Primary Biliary Cirrhosis	1.4	2.0	4.7	1.0	2.2	-0.4
Rheumatoid Arthritis	0.8	1.1	2.7	1.6	0.8	-0.2
Schizophrenia (2014)	2.3	5.0	9.1	-3.0	-2.4	0.1
Triglycerides	0.2	0.3	0.7	-0.3	-0.0	-0.8
Type 2 Diabetes (T2D) (2012)	2.5	2.9	7.5	-0.7	-0.8	-2.7
Ulcerative Colitis	1.0	1.5	2.9	-1.7	-1.2	0.3
Blood Eosinophil Count	0.7	5.2	9.5	-0.0	-2.5	-3.1
Blood Platelet Count	0.5	5.7	10.3	3.2	2.5	-0.9
Blood Red Count	0.4	4.2	7.1	-1.3	-2.7	-2.0
Blood White Count	1.9	13.8	17.0	-3.0	-4.1	-3.9
Heel T-Score	1.7	13.3	33.8	-1.0	-2.2	-5.8
BMI	0.4	2.5	7.4	-0.0	-0.2	-2.7
Height	0.1	1.9	4.2	1.0	2.0	0.7
Waist Hip Ratio (WHR)	0.1	0.6	0.7	0.6	-0.8	-0.8
Systolic Blood Pressure	1.8	9.1	26.9	0.0	0.5	5.2
Smoking Status	0.0	0.1	0.2	-0.4	0.1	0.2
Allergy or Eczema	0.2	0.6	0.9	0.8	0.9	0.5
Cardiovascular Disease	1.0	3.2	7.5	-1.4	0.4	2.7
Hypothyroidism (self reported)	0.2	0.4	0.9	-1.0	0.2	-0.4
Respiratory disease	0.8	1.9	5.1	-0.4	-2.3	-0.6
Type 2 Diabetes (T2D) (2018)	1.5	2.7	6.7	-0.9	-0.8	-2.6
Lung FEV1/FVC ratio	0.4	1.9	3.1	0.9	1.3	-1.8
Lung FVC	0.9	4.8	9.2	-2.2	-3.0	-0.7
Neuroticism	2.9	7.0	10.6	-3.2	-3.3	-0.1
Chronotype (morning person)	0.7	1.6	3.2	1.2	1.8	0.3
Hair Pigment	0.1	4.0	11.1	0.7	0.7	-3.3
Tanning	0.5	5.9	9.0	3.0	2.7	1.3
Hand grip strength (left)	2.3	6.1	14.7	1.5	1.1	3.8
Number of treatments/medications taken	3.3	5.9	9.3	-3.0	-2.9	-0.5
Average weekly spirits intake	0.2	0.3	0.7	0.5	0.1	0.8
Sensitivity / hurt feelings	9.5	16.3	29.0	-5.4	-4.4	-0.6
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.2	0.1	0.1	0.4
Hearing difficulty/problems: Yes	0.4	0.7	2.0	1.4	-0.1	-0.2
Relative age of first facial hair	0.5	1.0	2.9	1.7	0.1	0.4
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	3.5	-0.9	-1.9	0.6
Ever used hormone-replacement therapy (HRT)	0.7	1.0	2.8	-0.0	-0.2	-1.7
Ever had hysterectomy (womb removed)	0.4	0.4	1.2	-1.1	0.2	-0.1
Systolic blood pressure, automated reading	1.3	3.7	9.9	-0.5	-1.0	3.1
Eye problems/disorders: Diabetes related eye disease	3.4	3.8	5.7	-2.3	-2.4	-0.6
Angina	0.5	0.6	1.3	-1.1	-0.5	0.6
Medication for hormone replacement therapy	0.1	0.1	0.2	0.4	0.3	0.1
Vitamin and mineral supplements	5.9	8.0	8.9	2.5	2.9	3.0
Supplements: Zinc	1.4	1.5	3.7	-0.2	-0.9	-1.9
Medication: Co-codamol	0.6	0.7	2.2	0.0	0.1	1.5
Medication: Metformin	1.0	1.4	2.4	-1.0	-0.9	-1.6
Diabetes (father)	2.7	3.4	5.3	2.0	2.3	-0.9
Diabetes (mother)	0.3	0.4	0.8	0.5	-0.1	-0.9
Severe depression (siblings)	3.5	3.9	7.4	-2.7	-2.0	-0.3
Pack years adult smoking proportion	0.4	0.6	0.7	0.7	0.8	0.7
Impedance of leg (right)	0.6	2.9	6.6	0.3	1.4	2.6
Leg fat-free mass (left)	0.3	1.7	5.1	0.3	-0.2	-2.3
Trunk fat percentage	1.0	3.8	9.2	-0.9	-1.2	-3.0
Hand grip strength (right)	2.9	7.8	10.6	2.7	2.4	3.3
Townsend deprivation index at recruitment	0.7	0.9	2.1	-1.4	-0.8	0.3
Current tobacco smoking	0.4	0.7	1.5	-0.1	0.7	1.2
Average weekly fortified wine intake	0.7	0.8	1.9	-0.0	-1.4	-0.8
Maternal smoking around birth	0.4	0.6	1.1	0.6	1.0	-0.7
Fed-up feelings	0.0	0.1	0.1	-0.2	-0.3	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.1	-0.9	1.0	0.4
Relative age voice broke	0.4	0.7	1.0	1.0	-0.4	-0.9
Taking other prescription medications	2.6	4.1	7.8	-2.1	-2.8	0.4
Age when periods started (menarche)	0.7	1.7	3.7	1.9	1.1	0.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	-0.3	-0.1	0.7
Heel bone mineral density (BMD) T-score, automated (left)	2.5	5.7	14.5	-0.4	-1.6	-3.8
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.8	-0.8	-1.3	-0.2
Qualifications: CSEs or equivalent	1.1	1.5	3.0	-1.7	-0.5	-1.1
Serious illness, injury or assault to yourself	0.3	0.3	0.6	-0.6	-0.8	-0.2
High blood pressure	1.1	3.0	5.5	-1.7	-0.9	2.3
Hayfever, allergic rhinitis or eczema	0.9	1.9	3.3	1.3	1.8	0.8
Multivitamins +/- minerals	4.5	5.8	11.7	-1.6	-1.8	-3.4
Stomach or abdominal pain in last month	0.7	0.9	1.9	0.1	0.8	1.4
Supplements: Glucosamine	0.2	0.2	0.4	0.5	-0.2	0.7
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	2.0	-1.4	-0.6	-1.3
Medication: Atenolol	0.3	0.3	0.6	-0.7	0.2	0.6
Medication: Levothyroxine sodium	0.1	0.1	0.2	-0.4	0.1	0.3
Sitting height	0.0	0.2	0.7	0.1	0.8	0.2
Chronic bronchitis/emphysema (father)	2.9	3.4	6.0	-2.4	-2.1	-0.0
High blood pressure (mother)	0.4	0.6	1.3	-0.5	-0.4	1.1
Body mass index (BMI)	0.6	2.4	6.6	0.0	-0.7	-2.6
Impedance of leg (left)	0.8	3.8	8.4	0.2	1.7	2.9
Leg predicted mass (left)	0.3	1.6	4.5	0.3	-0.2	-2.1
Trunk fat mass	0.8	3.5	9.2	-0.6	-1.0	-3.0
Waist circumference	1.2	4.5	12.9	0.0	-0.7	-3.6
Number of incorrect matches in round	1.5	2.5	4.2	-1.4	-2.1	-1.2
Past tobacco smoking	0.5	1.0	1.7	0.9	0.7	1.3
Alcohol usually taken with meals	1.4	2.2	3.4	1.8	1.8	-0.1
Nervous feelings	3.8	7.1	9.8	-3.1	-3.1	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	-0.3	-0.1	-0.2
Hearing difficulty/problems with background noise	2.0	3.2	4.7	-1.2	-2.2	-1.9
Hair/balding pattern: Pattern 2	1.6	2.0	3.8	-1.9	-1.3	-0.8
Had menopause	0.3	0.4	1.1	0.3	-0.2	-1.1
Had other major operations	0.4	0.5	0.9	0.7	1.0	0.1
Forced vital capacity (FVC)	0.2	0.8	1.2	-1.1	-0.9	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	2.9	6.6	16.8	-0.3	-1.7	-4.1
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	1.8	-0.1	-1.0	1.3
Qualifications: None of the above	0.2	0.5	1.0	-0.1	1.0	0.7
Financial difficulties in last 2 years	0.8	1.1	1.5	-1.2	-1.2	-0.5
Mouth/teeth dental problems	0.3	0.5	0.7	0.7	0.8	0.5
Heart attack	0.8	1.0	1.2	-0.7	-1.1	1.1
Allergy	0.1	0.2	0.4	-0.6	-0.3	0.0
Pain all over the body in last month	0.7	0.7	0.9	-0.9	0.7	0.9
Diabetes (self-reported)	1.1	1.7	2.1	-1.3	-1.2	-1.4
Hayfever/allergic rhinitis (self-reported)	2.1	2.8	4.5	1.8	2.1	0.7
Medication: Ramipril	0.4	0.6	0.8	-0.9	-0.5	0.8
Medication: Simvastatin	1.1	1.6	2.5	-1.2	-0.9	1.6
Fluid intelligence score	0.4	0.9	2.1	-0.8	-0.2	1.4
Illnesses of siblings	1.0	1.5	3.9	2.0	0.7	-0.0
Neuroticism score	2.3	4.8	8.1	-2.9	-2.5	-0.1
Weight	0.4	1.9	5.4	0.4	-0.0	-2.3
Impedance of arm (right)	0.3	1.3	1.9	-1.3	-0.6	-1.4
Arm fat percentage (right)	1.9	7.4	17.4	-1.2	-1.8	-4.2
Trunk fat-free mass	0.2	1.4	2.7	1.6	0.9	-0.7
Hip circumference	0.9	3.7	10.8	0.4	0.1	-3.3
Time employed in main current job	0.6	0.7	1.7	-0.1	-0.6	1.3
Alcohol intake versus 10 years previously	0.0	0.0	0.0	-0.1	0.2	-0.2
Father’s age at death	1.5	2.1	4.2	2.1	1.2	-0.7
Worrier / anxious feelings	1.8	3.3	6.9	-1.6	-2.6	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.9	-0.0	0.2	1.7
Falls in the last year	1.0	1.4	3.9	2.0	0.5	0.2
Hair/balding pattern: Pattern 3	5.4	8.1	12.6	2.8	3.5	1.9
Number of live births	0.3	0.5	1.2	0.1	1.1	0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.1	-0.7	-0.7	-1.1
Pulse rate	2.1	3.5	4.4	-1.7	-2.1	-1.8
Happiness	0.8	1.0	1.4	-0.6	-1.1	1.2
Noisy workplace	0.8	1.0	1.9	-0.2	-1.4	-1.0
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.1	0.3	-0.4	0.3
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	3.2	0.6	1.8	-0.1
Mouth/teeth dental problems: Dentures	0.3	0.5	1.0	0.6	-0.4	-1.0
Asthma	1.0	1.9	3.2	0.4	-1.8	-1.5
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.4	0.3	1.6	-1.3
Medication: Cholesterol lowering	3.4	5.2	8.8	-3.0	-2.3	1.3
Depression (self-reported)	1.7	2.0	4.4	-2.1	-1.2	-0.3
Medication: Lansoprazole	1.8	2.0	3.4	0.7	1.8	1.5
Prospective memory result	0.2	0.2	0.5	0.7	-0.4	-0.0
Lung cancer (father)	0.9	1.0	3.1	-0.1	-0.1	1.8
Illnesses of mother	0.6	0.8	1.6	1.3	0.8	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	1.4	-0.9	-0.6	-1.2
Pulse wave Arterial Stiffness index	1.3	1.5	2.8	-0.6	-1.1	-1.7
Impedance of arm (left)	0.3	1.2	2.6	-1.6	-0.5	-0.9
Arm fat mass (right)	1.1	4.4	12.3	-0.5	-0.9	-3.5
Trunk predicted mass	0.2	1.3	2.6	1.6	0.9	-0.8
Standing height	0.1	0.9	1.8	0.9	1.4	-0.2
Length of working week for main job	0.9	1.0	1.9	-0.7	0.7	-1.4
Exposure to tobacco smoke at home	2.0	2.3	3.9	-2.0	-1.6	-0.6
Breastfed as a baby	1.2	1.5	2.2	-1.5	-1.1	-1.0
Tense / ‘highly strung’	1.2	1.9	4.0	-2.0	-1.2	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.7	5.9	-2.4	-1.1	-1.0
Hair/balding pattern: Pattern 4	1.2	2.8	6.7	-0.5	-2.6	-1.2
Birth weight of first child	0.0	0.1	0.2	-0.1	0.0	0.5
Peak expiratory flow (PEF)	0.2	0.5	1.3	1.2	-0.3	-0.0
Pulse wave reflection index	0.5	0.6	1.5	1.2	0.3	-0.3
Ever highly irritable/argumentative for 2 days	1.1	1.4	2.6	1.6	0.8	1.0
Loud music exposure frequency	0.8	0.9	2.7	0.0	-1.6	0.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.3	-0.5	-0.4	1.1
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	2.9	-1.7	-0.6	1.6
Blood clot in the leg (DVT)	0.9	1.2	1.7	-1.0	-0.8	-1.3
Medication: Paracetamol	0.4	0.6	1.1	-0.9	-1.0	-0.2
Headache pain in last month	0.1	0.2	0.6	-0.3	-0.8	-0.1
Medication for cholesterol, blood pressure or diabetes	3.8	6.3	11.1	3.3	1.7	-2.2
Glaucoma (self-reported)	0.5	0.6	1.0	0.8	1.0	0.0
Gout (self-reported)	0.4	0.6	0.6	0.7	-0.8	-0.7
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	-0.6	0.1	0.3
Medication: Amlodipine	1.2	1.6	4.5	-0.5	0.3	2.1
Medication: Ventolin 100micrograms inhaler	1.3	1.6	2.5	-1.6	-1.3	-0.8
Birth weight	1.5	3.4	5.8	2.4	2.0	0.7
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.1	1.5	1.1	0.8
High blood pressure (siblings)	2.9	4.2	9.6	-3.1	-1.6	0.8
Forced vital capacity (FVC), Best measure	0.4	1.4	1.6	-1.2	-1.0	-1.3
Body fat percentage	0.9	3.7	9.1	-0.9	-1.2	-3.0
Leg fat percentage (right)	0.3	1.2	3.2	-0.3	-0.5	-1.8
Arm fat-free mass (right)	0.2	0.9	1.8	1.3	1.0	-0.2
Exposure to tobacco smoke outside home	0.7	0.9	2.0	-0.8	-0.3	-1.4
Comparative body size at age 10	1.0	2.9	3.4	1.4	1.8	-1.8
Number of full brothers	0.1	0.1	0.3	0.2	0.5	-0.3
Worry too long after embarrassment	2.8	4.8	7.2	-2.2	-2.7	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.5	-0.2	0.3	0.7
Wheeze or whistling in the chest in last year	0.1	0.1	0.4	0.2	0.0	0.6
Number of children fathered	0.0	0.0	0.1	0.3	-0.2	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.7	0.8	-0.6	-0.1
Age at first live birth	0.6	1.0	2.0	0.2	1.1	1.4
Pulse wave peak to peak time	1.6	1.9	3.3	0.7	1.4	1.8
Health satisfaction	0.3	0.4	1.0	0.4	-0.0	1.0
Shortness of breath walking on level ground	0.1	0.1	0.3	0.0	-0.3	-0.5
Qualifications: College or University degree	0.2	0.7	1.6	-0.4	-1.3	0.6
Eye problems/disorders: None of the above	1.7	2.0	3.0	1.7	1.7	-0.2
Mouth/teeth dental problems: Loose teeth	0.8	0.9	1.6	1.0	1.3	0.3
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.0	0.4	0.3
Medication for pain relief, constipation, heartburn	0.1	0.1	0.4	0.6	0.1	0.1
Neck or shoulder pain in last month	0.4	0.5	0.7	-0.8	-0.8	0.4
Medication: Blood pressure	2.9	5.0	7.2	-2.6	-1.1	2.7
Angina (self-reported)	0.3	0.4	0.8	-0.9	-0.5	0.3
Migraine (self-reported)	0.9	1.1	2.1	-0.3	-1.1	-1.4
Medication: Ibuprofen	0.7	0.8	0.9	0.8	0.9	-0.9
Medication: Allopurinol	0.5	0.6	1.5	0.4	-1.2	-0.6
Medication: Omeprazole	0.1	0.2	0.2	-0.5	-0.4	0.2
Medication: Seretide 50 evohaler	0.2	0.2	0.4	0.6	-0.3	-0.4
Mean time to correctly identify matches	0.1	0.1	0.3	0.5	0.1	0.2
Heart disease (mother)	0.0	0.0	0.0	-0.1	0.0	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.1	0.5	0.5	-1.1
Whole body fat mass	0.7	3.1	8.7	-0.4	-0.7	-3.0
Leg fat mass (right)	0.5	1.9	5.6	-0.1	-0.3	-2.4
Arm predicted mass (right)	0.1	0.7	1.4	1.2	0.8	-0.1
Pulse rate, automated reading	1.9	6.3	8.3	-2.8	-2.9	-1.7
Alcohol intake frequency.	0.5	1.1	2.0	-1.4	-0.9	-0.7
Comparative height size at age 10	0.1	0.8	2.1	-0.1	-0.4	-1.5
Number of full sisters	2.0	2.4	4.2	1.4	2.0	1.1
Suffer from ‘nerves’	1.8	2.9	6.1	-2.5	-0.5	1.5
Overall health rating	1.4	3.0	5.7	-2.4	-1.7	-0.5
Chest pain or discomfort	0.3	0.4	0.7	-0.7	-0.3	0.9
Had major operations	3.2	3.8	5.4	-2.2	-2.3	-1.0
Age at last live birth	0.5	0.8	2.3	-0.0	0.2	1.5
Family relationship satisfaction	0.5	0.6	1.0	0.1	-1.0	-0.9
Leg pain on walking	1.4	1.8	3.0	-0.2	-1.7	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.9	0.4	-0.3	-0.9
Commuting to job workplace: Car/motor vehicle	1.4	1.6	2.5	1.6	1.4	-0.7
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.9	-0.3	-0.9	-0.2
Medication: Aspirin	1.2	1.6	3.8	-1.9	-0.8	0.5
Supplements: Vitamin C	1.3	1.6	2.7	-1.4	-1.6	-0.3
Knee pain experienced in last month	0.7	1.0	1.8	0.9	1.3	0.7
Hypertension (Self-reported)	1.2	3.3	6.3	-1.7	-0.8	2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.7	0.8	0.4	0.3
Illnesses of father: Heart disease	0.1	0.2	0.2	-0.5	-0.4	-0.3
Illnesses of siblings: Diabetes	0.8	1.0	2.1	-0.3	-0.9	-1.5
Smoking status: Previous	2.0	3.0	4.0	-1.3	-1.8	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.1	0.9	1.0	0.1
Whole body fat-free mass	0.2	1.1	1.5	1.2	0.6	-1.2
Leg fat-free mass (right)	0.3	1.5	4.4	0.3	-0.0	-2.1
Arm fat percentage (left)	1.5	6.0	14.1	-1.2	-1.6	-3.8
Average weekly red wine intake	0.2	0.3	0.4	0.2	0.6	0.6
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.1	-1.0	-0.1	-0.3
Mood swings	0.5	0.9	1.5	-0.8	-0.9	1.2
Loneliness, isolation	0.5	0.7	1.0	-1.0	-1.0	-0.5
Long-standing illness, disability or infirmity	1.7	2.6	4.4	-1.6	-2.1	0.9
Ever had bowel cancer screening	0.0	0.0	0.1	-0.2	0.2	0.0
Diabetes diagnosed by doctor	0.9	1.5	2.0	-1.4	-1.0	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	3.3	3.5	5.2	-2.1	-2.3	-1.0
Friendships satisfaction	0.1	0.1	0.4	0.6	-0.0	-0.1
Qualifications: nursing, teaching	0.2	0.2	0.4	0.6	0.5	-0.2
Commuting to job workplace: Walk	0.5	0.6	1.5	0.3	0.5	-1.2
Eye problems/disorders: Cataract	1.3	1.5	2.2	-1.2	-0.9	1.5
Mouth/teeth dental problems: Mouth ulcers	1.8	2.9	4.1	-2.0	-1.9	-1.1
Medication for cholesterol	0.6	0.9	2.1	0.3	-0.6	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.6	0.2	1.6	-0.7
Back pain experienced in last month	0.1	0.2	0.6	-0.1	-0.8	-0.2
Mineral and other dietary supplements	2.6	3.5	7.3	1.2	1.4	2.7
Breast cancer (self-reported)	0.8	0.9	2.3	-0.4	-0.5	-1.5
Asthma (self-reported)	1.0	1.9	3.9	0.2	-2.0	-1.4
Osteoporosis (self-reported)	1.3	1.6	3.5	-1.9	-0.7	1.0
Osteoarthritis (self-reported)	0.7	0.9	2.6	-0.1	-0.4	-1.6
Medication: Aspirin	1.3	1.7	3.7	-1.9	-1.1	0.4
Medication: Gliclazide	1.6	1.9	4.1	-0.1	-1.2	-2.0
Illnesses of father: None of the above (group 1)	0.0	0.0	0.0	-0.1	0.1	-0.2
Smoking status: Current	0.4	0.7	1.2	0.1	0.9	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.1	5.7	-2.4	-1.7	-0.8
Whole body water mass	0.2	1.1	1.7	1.1	0.5	-1.3
Leg predicted mass (right)	0.3	1.4	4.2	0.3	-0.0	-2.0
Arm fat mass (left)	1.1	4.5	12.4	-0.4	-0.9	-3.5
Number of self-reported non-cancer illnesses	1.0	1.7	2.5	-1.6	-1.2	1.2
Average weekly champagne plus white wine intake	2.1	2.9	4.8	2.2	1.3	1.6
Miserableness	0.3	0.5	0.8	-0.4	-0.8	-0.9
Guilty feelings	0.2	0.3	0.6	-0.2	-0.6	-0.8
Wears glasses or contact lenses	0.1	0.1	0.2	0.0	-0.1	-0.5
Ever taken oral contraceptive pill	0.7	0.8	1.6	0.9	1.3	-0.0
Hearing aid user	3.1	3.5	7.4	2.7	1.7	0.5
Mother’s age at death	1.1	1.4	3.6	1.9	0.8	0.2
Financial situation satisfaction	0.2	0.2	0.4	0.6	-0.5	0.1
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.5	0.7	0.7	0.4
Commuting to job workplace: Public transport	3.1	3.7	5.0	-2.2	-2.1	1.4
Eye problems/disorders: Glaucoma	0.1	0.2	0.4	0.3	0.6	0.0
Medication: Blood pressure	0.8	1.6	4.4	-0.1	0.6	2.1
Pain type(s) experienced in last month: Hip pain	1.2	1.6	3.6	-0.8	-1.9	-0.7
Supplements: Fish oil (including cod liver oil)	1.7	2.3	5.4	-0.1	-1.2	-2.3
High cholesterol (Self-reported)	1.5	2.6	3.9	-2.0	-1.3	1.5
Medication: Bendroflumethiazide	1.6	2.4	5.6	-1.0	0.7	2.4
Medication: Paracetamol	0.3	0.4	0.8	-0.5	-0.9	0.3
Medication: Lisinopril	0.8	1.0	2.5	0.5	0.6	1.6
Medication: Atorvastatin	3.1	3.9	7.3	-2.7	-2.1	-0.2
Illnesses of father: High blood pressure	2.8	3.4	5.3	1.4	1.8	2.3
Alcohol drinker status: Never	0.1	0.1	0.2	0.4	-0.2	0.5
Ever smoked	0.1	0.2	0.5	-0.7	0.0	0.2
Basal metabolic rate	0.2	1.3	2.7	1.0	0.4	-1.6
Leg fat percentage (left)	0.3	0.9	2.5	-0.4	-0.3	-1.6
Arm fat-free mass (left)	0.2	1.2	2.0	1.4	0.9	-0.9
Number of operations (self-reported)	1.3	1.9	3.5	-1.2	-0.8	-1.9
Average weekly beer plus cider intake	0.8	1.2	3.5	-0.1	0.1	1.9
Irritability	0.7	1.1	2.1	-1.1	-1.5	0.3
Risk taking	1.6	2.3	3.0	-1.3	-1.5	-1.7
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.7	-0.6	0.8	0.1
Fractured/broken bones in last 5 years	0.3	0.3	0.5	0.7	0.5	0.5
Age started oral contraceptive pill	2.2	2.7	3.9	-0.6	-2.0	-2.0
Diastolic blood pressure, automated reading	0.8	2.5	3.3	-1.6	-1.8	1.2
Ever depressed for a whole week	0.4	0.5	0.9	1.0	-0.6	-0.3
Unable to work because of sickness or disability	0.5	0.7	1.5	-1.2	-0.7	-0.4
Commuting to job workplace: Cycle	1.2	1.4	2.8	-0.6	-1.7	1.1
Myopia	1.1	1.6	1.8	-1.2	-1.3	-1.2
Vascular/heart problems diagnosed by doctor	1.0	2.7	4.3	1.6	1.1	-2.1
Cholesterol lowering medication	0.2	0.2	0.6	-0.8	-0.2	0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.4	0.3	0.0	0.6
Pain experienced in last month	0.1	0.1	0.3	-0.4	0.1	-0.5
Supplements: Calcium	7.7	8.5	11.4	-3.4	-3.1	-2.2
Basal cell carcinoma (self-reported)	1.9	2.3	5.4	-0.3	1.2	2.3
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.1	-0.9	-1.0	1.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.4	-0.8	-0.4	-1.2
Heart disease (siblings)	0.1	0.2	0.5	-0.7	-0.1	0.0
Alcohol drinker status: Previous	1.2	1.3	1.8	-1.3	-1.1	-1.1
Pack years of smoking	0.3	0.4	0.7	0.6	0.8	0.5
Impedance of whole body	0.1	0.5	0.6	-0.7	0.7	0.8
Leg fat mass (left)	0.4	1.5	4.4	-0.0	0.0	-2.1
Arm predicted mass (left)	0.2	0.9	1.7	1.3	0.9	-0.6