TWAS hub - PRSS3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2120	0.0460	1.6e-14	0.122	0.144	0.161	0.160	0.153	1.2e-14	4.0e-17	3.8e-19	4.8e-19	3.6e-18
2	ROSMAP	Brain Pre-frontal Cortex	0.1575	0.0424	8.4e-14	0.053	0.120	0.134	0.129	0.136	2.1e-07	4.0e-15	7.1e-17	3.4e-16	3.9e-17
3	TCGA	Brain Lower Grade Glioma	0.0431	0.0248	1.7e-03	0.005	0.017	0.000	NA	0.005	7.1e-02	4.5e-03	2.9e-01	NA	8.6e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Sensitivity / hurt feelings	9.5	16.3	29.0	-5.4	-4.4	-0.6
Supplements: Calcium	7.7	8.5	11.4	-3.4	-3.1	-2.2
Vitamin and mineral supplements	5.9	8.0	8.9	2.5	2.9	3.0
Hair/balding pattern: Pattern 3	5.4	8.1	12.6	2.8	3.5	1.9
Multivitamins +/- minerals	4.5	5.8	11.7	-1.6	-1.8	-3.4
Prostate Cancer	4.3	6.1	9.6	1.9	2.2	3.1
Worry (Nagel 2018)	3.9	8.1	14.2	-3.8	-3.2	0.4
Nervous feelings	3.8	7.1	9.8	-3.1	-3.1	1.4
Medication for cholesterol, blood pressure or diabetes	3.8	6.3	11.1	3.3	1.7	-2.2
Severe depression (siblings)	3.5	3.9	7.4	-2.7	-2.0	-0.3
Eye problems/disorders: Diabetes related eye disease	3.4	3.8	5.7	-2.3	-2.4	-0.6
Medication: Cholesterol lowering	3.4	5.2	8.8	-3.0	-2.3	1.3
Number of treatments/medications taken	3.3	5.9	9.3	-3.0	-2.9	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	3.3	3.5	5.2	-2.1	-2.3	-1.0
Had major operations	3.2	3.8	5.4	-2.2	-2.3	-1.0
Hearing aid user	3.1	3.5	7.4	2.7	1.7	0.5
Commuting to job workplace: Public transport	3.1	3.7	5.0	-2.2	-2.1	1.4
Medication: Atorvastatin	3.1	3.9	7.3	-2.7	-2.1	-0.2
Neuroticism	2.9	7.0	10.6	-3.2	-3.3	-0.1
Hand grip strength (right)	2.9	7.8	10.6	2.7	2.4	3.3
Chronic bronchitis/emphysema (father)	2.9	3.4	6.0	-2.4	-2.1	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	2.9	6.6	16.8	-0.3	-1.7	-4.1
High blood pressure (siblings)	2.9	4.2	9.6	-3.1	-1.6	0.8
Medication: Blood pressure	2.9	5.0	7.2	-2.6	-1.1	2.7
Worry too long after embarrassment	2.8	4.8	7.2	-2.2	-2.7	-1.4
Illnesses of father: High blood pressure	2.8	3.4	5.3	1.4	1.8	2.3
Diabetes (father)	2.7	3.4	5.3	2.0	2.3	-0.9
Taking other prescription medications	2.6	4.1	7.8	-2.1	-2.8	0.4
Mineral and other dietary supplements	2.6	3.5	7.3	1.2	1.4	2.7
Neuroticism (Nagel 2018)	2.5	5.9	8.7	-3.0	-2.9	-0.7
Type 2 Diabetes (T2D) (2012)	2.5	2.9	7.5	-0.7	-0.8	-2.7
Heel bone mineral density (BMD) T-score, automated (left)	2.5	5.7	14.5	-0.4	-1.6	-3.8
Lupus	2.4	3.7	4.9	-2.2	-2.2	-1.2
Schizophrenia (2014)	2.3	5.0	9.1	-3.0	-2.4	0.1
Hand grip strength (left)	2.3	6.1	14.7	1.5	1.1	3.8
Neuroticism score	2.3	4.8	8.1	-2.9	-2.5	-0.1
Neuroticism (2016)	2.2	3.1	5.2	-2.3	-1.7	-1.1
Age started oral contraceptive pill	2.2	2.7	3.9	-0.6	-2.0	-2.0
Hayfever/allergic rhinitis (self-reported)	2.1	2.8	4.5	1.8	2.1	0.7
Pulse rate	2.1	3.5	4.4	-1.7	-2.1	-1.8
Average weekly champagne plus white wine intake	2.1	2.9	4.8	2.2	1.3	1.6
Hearing difficulty/problems with background noise	2.0	3.2	4.7	-1.2	-2.2	-1.9
Exposure to tobacco smoke at home	2.0	2.3	3.9	-2.0	-1.6	-0.6
Number of full sisters	2.0	2.4	4.2	1.4	2.0	1.1
Smoking status: Previous	2.0	3.0	4.0	-1.3	-1.8	-2.0
Bipolar Disorder or Schizophrenia	1.9	4.6	7.6	-2.8	-2.4	-0.5
Blood White Count	1.9	13.8	17.0	-3.0	-4.1	-3.9
Arm fat percentage (right)	1.9	7.4	17.4	-1.2	-1.8	-4.2
Pulse rate, automated reading	1.9	6.3	8.3	-2.8	-2.9	-1.7
Basal cell carcinoma (self-reported)	1.9	2.3	5.4	-0.3	1.2	2.3
Systolic Blood Pressure	1.8	9.1	26.9	0.0	0.5	5.2
Worrier / anxious feelings	1.8	3.3	6.9	-1.6	-2.6	0.7
Medication: Lansoprazole	1.8	2.0	3.4	0.7	1.8	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.7	5.9	-2.4	-1.1	-1.0
Suffer from ‘nerves’	1.8	2.9	6.1	-2.5	-0.5	1.5
Mouth/teeth dental problems: Mouth ulcers	1.8	2.9	4.1	-2.0	-1.9	-1.1
Heel T-Score	1.7	13.3	33.8	-1.0	-2.2	-5.8
Depression (self-reported)	1.7	2.0	4.4	-2.1	-1.2	-0.3
Eye problems/disorders: None of the above	1.7	2.0	3.0	1.7	1.7	-0.2
Long-standing illness, disability or infirmity	1.7	2.6	4.4	-1.6	-2.1	0.9
Supplements: Fish oil (including cod liver oil)	1.7	2.3	5.4	-0.1	-1.2	-2.3
Schizophrenia vs Biploar Disorder	1.6	2.1	2.4	-1.3	-1.5	1.5
Hair/balding pattern: Pattern 2	1.6	2.0	3.8	-1.9	-1.3	-0.8
Pulse wave peak to peak time	1.6	1.9	3.3	0.7	1.4	1.8
Medication: Gliclazide	1.6	1.9	4.1	-0.1	-1.2	-2.0
Medication: Bendroflumethiazide	1.6	2.4	5.6	-1.0	0.7	2.4
Risk taking	1.6	2.3	3.0	-1.3	-1.5	-1.7
Bipolar Disorder (2011)	1.5	1.4	2.5	-1.6	-1.3	-0.3
Type 2 Diabetes (T2D) (2018)	1.5	2.7	6.7	-0.9	-0.8	-2.6
Number of incorrect matches in round	1.5	2.5	4.2	-1.4	-2.1	-1.2
Father’s age at death	1.5	2.1	4.2	2.1	1.2	-0.7
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	2.9	-1.7	-0.6	1.6
Birth weight	1.5	3.4	5.8	2.4	2.0	0.7
Arm fat percentage (left)	1.5	6.0	14.1	-1.2	-1.6	-3.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.1	5.7	-2.4	-1.7	-0.8
High cholesterol (Self-reported)	1.5	2.6	3.9	-2.0	-1.3	1.5
Schizophrenia (2018)	1.4	3.0	5.2	-2.3	-1.9	-0.1
Ovarian Cancer	1.4	1.9	3.8	-0.4	-1.3	-1.9
Mean Putamen Volume	1.4	1.5	2.1	1.4	1.3	1.0
Primary Biliary Cirrhosis	1.4	2.0	4.7	1.0	2.2	-0.4
Supplements: Zinc	1.4	1.5	3.7	-0.2	-0.9	-1.9
Alcohol usually taken with meals	1.4	2.2	3.4	1.8	1.8	-0.1
Overall health rating	1.4	3.0	5.7	-2.4	-1.7	-0.5
Leg pain on walking	1.4	1.8	3.0	-0.2	-1.7	-1.5
Commuting to job workplace: Car/motor vehicle	1.4	1.6	2.5	1.6	1.4	-0.7
Systolic blood pressure, automated reading	1.3	3.7	9.9	-0.5	-1.0	3.1
Pulse wave Arterial Stiffness index	1.3	1.5	2.8	-0.6	-1.1	-1.7
Medication: Ventolin 100micrograms inhaler	1.3	1.6	2.5	-1.6	-1.3	-0.8
Supplements: Vitamin C	1.3	1.6	2.7	-1.4	-1.6	-0.3
Eye problems/disorders: Cataract	1.3	1.5	2.2	-1.2	-0.9	1.5
Osteoporosis (self-reported)	1.3	1.6	3.5	-1.9	-0.7	1.0
Medication: Aspirin	1.3	1.7	3.7	-1.9	-1.1	0.4
Number of operations (self-reported)	1.3	1.9	3.5	-1.2	-0.8	-1.9
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	3.5	-0.9	-1.9	0.6
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	2.0	-1.4	-0.6	-1.3
Waist circumference	1.2	4.5	12.9	0.0	-0.7	-3.6
Breastfed as a baby	1.2	1.5	2.2	-1.5	-1.1	-1.0
Tense / ‘highly strung’	1.2	1.9	4.0	-2.0	-1.2	-0.6
Hair/balding pattern: Pattern 4	1.2	2.8	6.7	-0.5	-2.6	-1.2
Medication: Amlodipine	1.2	1.6	4.5	-0.5	0.3	2.1
Medication: Aspirin	1.2	1.6	3.8	-1.9	-0.8	0.5
Hypertension (Self-reported)	1.2	3.3	6.3	-1.7	-0.8	2.5
Pain type(s) experienced in last month: Hip pain	1.2	1.6	3.6	-0.8	-1.9	-0.7
Commuting to job workplace: Cycle	1.2	1.4	2.8	-0.6	-1.7	1.1
Alcohol drinker status: Previous	1.2	1.3	1.8	-1.3	-1.1	-1.1
Bipolar Disorder (2018)	1.1	1.7	2.5	-1.6	-1.5	-0.7
Qualifications: CSEs or equivalent	1.1	1.5	3.0	-1.7	-0.5	-1.1
High blood pressure	1.1	3.0	5.5	-1.7	-0.9	2.3
Diabetes (self-reported)	1.1	1.7	2.1	-1.3	-1.2	-1.4
Medication: Simvastatin	1.1	1.6	2.5	-1.2	-0.9	1.6
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.4	0.3	1.6	-1.3
Arm fat mass (right)	1.1	4.4	12.3	-0.5	-0.9	-3.5
Ever highly irritable/argumentative for 2 days	1.1	1.4	2.6	1.6	0.8	1.0
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.1	1.5	1.1	0.8
Arm fat mass (left)	1.1	4.5	12.4	-0.4	-0.9	-3.5
Mother’s age at death	1.1	1.4	3.6	1.9	0.8	0.2
Myopia	1.1	1.6	1.8	-1.2	-1.3	-1.2
Verbal and Numeric Reasoning (VNR)	1.0	2.3	4.8	1.3	0.7	2.2
Fasting Glucose	1.0	1.2	3.2	0.6	-0.2	1.8
Ulcerative Colitis	1.0	1.5	2.9	-1.7	-1.2	0.3
Cardiovascular Disease	1.0	3.2	7.5	-1.4	0.4	2.7
Medication: Metformin	1.0	1.4	2.4	-1.0	-0.9	-1.6
Trunk fat percentage	1.0	3.8	9.2	-0.9	-1.2	-3.0
Illnesses of siblings	1.0	1.5	3.9	2.0	0.7	-0.0
Falls in the last year	1.0	1.4	3.9	2.0	0.5	0.2
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	3.2	0.6	1.8	-0.1
Asthma	1.0	1.9	3.2	0.4	-1.8	-1.5
Comparative body size at age 10	1.0	2.9	3.4	1.4	1.8	-1.8
Asthma (self-reported)	1.0	1.9	3.9	0.2	-2.0	-1.4
Number of self-reported non-cancer illnesses	1.0	1.7	2.5	-1.6	-1.2	1.2
Vascular/heart problems diagnosed by doctor	1.0	2.7	4.3	1.6	1.1	-2.1
Lung FVC	0.9	4.8	9.2	-2.2	-3.0	-0.7
Hayfever, allergic rhinitis or eczema	0.9	1.9	3.3	1.3	1.8	0.8
Hip circumference	0.9	3.7	10.8	0.4	0.1	-3.3
Lung cancer (father)	0.9	1.0	3.1	-0.1	-0.1	1.8
Length of working week for main job	0.9	1.0	1.9	-0.7	0.7	-1.4
Blood clot in the leg (DVT)	0.9	1.2	1.7	-1.0	-0.8	-1.3
Body fat percentage	0.9	3.7	9.1	-0.9	-1.2	-3.0
Migraine (self-reported)	0.9	1.1	2.1	-0.3	-1.1	-1.4
Diabetes diagnosed by doctor	0.9	1.5	2.0	-1.4	-1.0	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.6	0.2	1.6	-0.7
Rheumatoid Arthritis	0.8	1.1	2.7	1.6	0.8	-0.2
Respiratory disease	0.8	1.9	5.1	-0.4	-2.3	-0.6
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.8	-0.8	-1.3	-0.2
Impedance of leg (left)	0.8	3.8	8.4	0.2	1.7	2.9
Trunk fat mass	0.8	3.5	9.2	-0.6	-1.0	-3.0
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	1.8	-0.1	-1.0	1.3
Financial difficulties in last 2 years	0.8	1.1	1.5	-1.2	-1.2	-0.5
Heart attack	0.8	1.0	1.2	-0.7	-1.1	1.1
Happiness	0.8	1.0	1.4	-0.6	-1.1	1.2
Noisy workplace	0.8	1.0	1.9	-0.2	-1.4	-1.0
Loud music exposure frequency	0.8	0.9	2.7	0.0	-1.6	0.2
Mouth/teeth dental problems: Loose teeth	0.8	0.9	1.6	1.0	1.3	0.3
Illnesses of siblings: Diabetes	0.8	1.0	2.1	-0.3	-0.9	-1.5
Breast cancer (self-reported)	0.8	0.9	2.3	-0.4	-0.5	-1.5
Medication: Blood pressure	0.8	1.6	4.4	-0.1	0.6	2.1
Medication: Lisinopril	0.8	1.0	2.5	0.5	0.6	1.6
Average weekly beer plus cider intake	0.8	1.2	3.5	-0.1	0.1	1.9
Diastolic blood pressure, automated reading	0.8	2.5	3.3	-1.6	-1.8	1.2
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.1	-0.9	-1.0	1.1
Irritable Bowel Disease (IBD)	0.7	1.8	3.1	-1.8	-1.5	0.1
Crohns Disease (2012)	0.7	1.1	2.0	-1.4	-1.0	-0.4
Blood Eosinophil Count	0.7	5.2	9.5	-0.0	-2.5	-3.1
Chronotype (morning person)	0.7	1.6	3.2	1.2	1.8	0.3
Ever used hormone-replacement therapy (HRT)	0.7	1.0	2.8	-0.0	-0.2	-1.7
Townsend deprivation index at recruitment	0.7	0.9	2.1	-1.4	-0.8	0.3
Average weekly fortified wine intake	0.7	0.8	1.9	-0.0	-1.4	-0.8
Age when periods started (menarche)	0.7	1.7	3.7	1.9	1.1	0.4
Stomach or abdominal pain in last month	0.7	0.9	1.9	0.1	0.8	1.4
Pain all over the body in last month	0.7	0.7	0.9	-0.9	0.7	0.9
Exposure to tobacco smoke outside home	0.7	0.9	2.0	-0.8	-0.3	-1.4
Medication: Ibuprofen	0.7	0.8	0.9	0.8	0.9	-0.9
Whole body fat mass	0.7	3.1	8.7	-0.4	-0.7	-3.0
Knee pain experienced in last month	0.7	1.0	1.8	0.9	1.3	0.7
Osteoarthritis (self-reported)	0.7	0.9	2.6	-0.1	-0.4	-1.6
Ever taken oral contraceptive pill	0.7	0.8	1.6	0.9	1.3	-0.0
Irritability	0.7	1.1	2.1	-1.1	-1.5	0.3
Crohns Disease (2017)	0.6	1.4	2.2	-1.5	-1.4	0.3
Body Mass Index (BMI) (2010)	0.6	0.8	1.6	1.3	0.9	-0.3
Medication: Co-codamol	0.6	0.7	2.2	0.0	0.1	1.5
Impedance of leg (right)	0.6	2.9	6.6	0.3	1.4	2.6
Body mass index (BMI)	0.6	2.4	6.6	0.0	-0.7	-2.6
Time employed in main current job	0.6	0.7	1.7	-0.1	-0.6	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.9	-0.0	0.2	1.7
Illnesses of mother	0.6	0.8	1.6	1.3	0.8	0.4
Age at first live birth	0.6	1.0	2.0	0.2	1.1	1.4
Medication for cholesterol	0.6	0.9	2.1	0.3	-0.6	-1.4
Ulcerative Colitis (UC)	0.5	0.9	2.0	-1.4	-0.8	-0.2
LDL Cholesterol	0.5	0.8	2.2	-0.0	1.5	-0.6
Blood Platelet Count	0.5	5.7	10.3	3.2	2.5	-0.9
Tanning	0.5	5.9	9.0	3.0	2.7	1.3
Relative age of first facial hair	0.5	1.0	2.9	1.7	0.1	0.4
Angina	0.5	0.6	1.3	-1.1	-0.5	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.1	-0.9	1.0	0.4
Past tobacco smoking	0.5	1.0	1.7	0.9	0.7	1.3
Pulse wave reflection index	0.5	0.6	1.5	1.2	0.3	-0.3
Glaucoma (self-reported)	0.5	0.6	1.0	0.8	1.0	0.0
Medication: Allopurinol	0.5	0.6	1.5	0.4	-1.2	-0.6
Leg fat mass (right)	0.5	1.9	5.6	-0.1	-0.3	-2.4
Alcohol intake frequency.	0.5	1.1	2.0	-1.4	-0.9	-0.7
Age at last live birth	0.5	0.8	2.3	-0.0	0.2	1.5
Family relationship satisfaction	0.5	0.6	1.0	0.1	-1.0	-0.9
Mood swings	0.5	0.9	1.5	-0.8	-0.9	1.2
Loneliness, isolation	0.5	0.7	1.0	-1.0	-1.0	-0.5
Commuting to job workplace: Walk	0.5	0.6	1.5	0.3	0.5	-1.2
Unable to work because of sickness or disability	0.5	0.7	1.5	-1.2	-0.7	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.4	-0.8	-0.4	-1.2
Depression (Nagel 2018)	0.4	0.6	1.2	-0.4	0.6	1.1
Alzheimer’s Disease (in father)	0.4	0.4	1.0	0.2	0.4	-1.0
Breast Cancer	0.4	0.9	1.5	1.2	1.1	-0.0
HDL Cholesterol	0.4	0.6	0.9	0.9	0.5	0.8
Blood Red Count	0.4	4.2	7.1	-1.3	-2.7	-2.0
BMI	0.4	2.5	7.4	-0.0	-0.2	-2.7
Lung FEV1/FVC ratio	0.4	1.9	3.1	0.9	1.3	-1.8
Hearing difficulty/problems: Yes	0.4	0.7	2.0	1.4	-0.1	-0.2
Ever had hysterectomy (womb removed)	0.4	0.4	1.2	-1.1	0.2	-0.1
Pack years adult smoking proportion	0.4	0.6	0.7	0.7	0.8	0.7
Current tobacco smoking	0.4	0.7	1.5	-0.1	0.7	1.2
Maternal smoking around birth	0.4	0.6	1.1	0.6	1.0	-0.7
Relative age voice broke	0.4	0.7	1.0	1.0	-0.4	-0.9
High blood pressure (mother)	0.4	0.6	1.3	-0.5	-0.4	1.1
Had other major operations	0.4	0.5	0.9	0.7	1.0	0.1
Medication: Ramipril	0.4	0.6	0.8	-0.9	-0.5	0.8
Fluid intelligence score	0.4	0.9	2.1	-0.8	-0.2	1.4
Weight	0.4	1.9	5.4	0.4	-0.0	-2.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.3	-0.5	-0.4	1.1
Medication: Paracetamol	0.4	0.6	1.1	-0.9	-1.0	-0.2
Gout (self-reported)	0.4	0.6	0.6	0.7	-0.8	-0.7
Forced vital capacity (FVC), Best measure	0.4	1.4	1.6	-1.2	-1.0	-1.3
Neck or shoulder pain in last month	0.4	0.5	0.7	-0.8	-0.8	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.1	0.5	0.5	-1.1
Smoking status: Current	0.4	0.7	1.2	0.1	0.9	1.1
Ever depressed for a whole week	0.4	0.5	0.9	1.0	-0.6	-0.3
Leg fat mass (left)	0.4	1.5	4.4	-0.0	0.0	-2.1
Depressed Affect (Nagel 2018)	0.3	0.7	1.1	-1.1	-1.0	-0.1
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.2	0.4	-0.5	1.5
Alzheimer’s Disease (in mother)	0.3	0.3	0.7	-0.3	0.3	0.8
Coronary Artery Disease (CAD)	0.3	0.3	0.6	0.7	0.5	-0.4
HbA1C	0.3	0.4	1.0	-0.3	-0.2	1.0
Diabetes (mother)	0.3	0.4	0.8	0.5	-0.1	-0.9
Leg fat-free mass (left)	0.3	1.7	5.1	0.3	-0.2	-2.3
Serious illness, injury or assault to yourself	0.3	0.3	0.6	-0.6	-0.8	-0.2
Medication: Atenolol	0.3	0.3	0.6	-0.7	0.2	0.6
Leg predicted mass (left)	0.3	1.6	4.5	0.3	-0.2	-2.1
Had menopause	0.3	0.4	1.1	0.3	-0.2	-1.1
Mouth/teeth dental problems	0.3	0.5	0.7	0.7	0.8	0.5
Impedance of arm (right)	0.3	1.3	1.9	-1.3	-0.6	-1.4
Number of live births	0.3	0.5	1.2	0.1	1.1	0.4
Mouth/teeth dental problems: Dentures	0.3	0.5	1.0	0.6	-0.4	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	1.4	-0.9	-0.6	-1.2
Impedance of arm (left)	0.3	1.2	2.6	-1.6	-0.5	-0.9
Leg fat percentage (right)	0.3	1.2	3.2	-0.3	-0.5	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.7	0.8	-0.6	-0.1
Health satisfaction	0.3	0.4	1.0	0.4	-0.0	1.0
Angina (self-reported)	0.3	0.4	0.8	-0.9	-0.5	0.3
Chest pain or discomfort	0.3	0.4	0.7	-0.7	-0.3	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.9	0.4	-0.3	-0.9
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.9	-0.3	-0.9	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.7	0.8	0.4	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.1	0.9	1.0	0.1
Leg fat-free mass (right)	0.3	1.5	4.4	0.3	-0.0	-2.1
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.1	-1.0	-0.1	-0.3
Leg predicted mass (right)	0.3	1.4	4.2	0.3	-0.0	-2.0
Miserableness	0.3	0.5	0.8	-0.4	-0.8	-0.9
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.5	0.7	0.7	0.4
Medication: Paracetamol	0.3	0.4	0.8	-0.5	-0.9	0.3
Leg fat percentage (left)	0.3	0.9	2.5	-0.4	-0.3	-1.6
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.7	-0.6	0.8	0.1
Fractured/broken bones in last 5 years	0.3	0.3	0.5	0.7	0.5	0.5
Pack years of smoking	0.3	0.4	0.7	0.6	0.8	0.5
Alzheimer’s Disease (including proxy)	0.2	0.2	0.5	-0.7	0.2	0.4
Major Depression (MDD)	0.2	0.3	0.5	-0.2	-0.5	0.7
Reaction Time	0.2	0.4	0.7	0.2	0.8	0.6
Triglycerides	0.2	0.3	0.7	-0.3	-0.0	-0.8
Allergy or Eczema	0.2	0.6	0.9	0.8	0.9	0.5
Hypothyroidism (self reported)	0.2	0.4	0.9	-1.0	0.2	-0.4
Average weekly spirits intake	0.2	0.3	0.7	0.5	0.1	0.8
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	-0.3	-0.1	0.7
Supplements: Glucosamine	0.2	0.2	0.4	0.5	-0.2	0.7
Forced vital capacity (FVC)	0.2	0.8	1.2	-1.1	-0.9	-0.6
Qualifications: None of the above	0.2	0.5	1.0	-0.1	1.0	0.7
Trunk fat-free mass	0.2	1.4	2.7	1.6	0.9	-0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.1	-0.7	-0.7	-1.1
Prospective memory result	0.2	0.2	0.5	0.7	-0.4	-0.0
Trunk predicted mass	0.2	1.3	2.6	1.6	0.9	-0.8
Peak expiratory flow (PEF)	0.2	0.5	1.3	1.2	-0.3	-0.0
Arm fat-free mass (right)	0.2	0.9	1.8	1.3	1.0	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.5	-0.2	0.3	0.7
Qualifications: College or University degree	0.2	0.7	1.6	-0.4	-1.3	0.6
Medication: Seretide 50 evohaler	0.2	0.2	0.4	0.6	-0.3	-0.4
Whole body fat-free mass	0.2	1.1	1.5	1.2	0.6	-1.2
Average weekly red wine intake	0.2	0.3	0.4	0.2	0.6	0.6
Qualifications: nursing, teaching	0.2	0.2	0.4	0.6	0.5	-0.2
Whole body water mass	0.2	1.1	1.7	1.1	0.5	-1.3
Guilty feelings	0.2	0.3	0.6	-0.2	-0.6	-0.8
Financial situation satisfaction	0.2	0.2	0.4	0.6	-0.5	0.1
Basal metabolic rate	0.2	1.3	2.7	1.0	0.4	-1.6
Arm fat-free mass (left)	0.2	1.2	2.0	1.4	0.9	-0.9
Cholesterol lowering medication	0.2	0.2	0.6	-0.8	-0.2	0.2
Arm predicted mass (left)	0.2	0.9	1.7	1.3	0.9	-0.6
Height	0.1	1.9	4.2	1.0	2.0	0.7
Waist Hip Ratio (WHR)	0.1	0.6	0.7	0.6	-0.8	-0.8
Hair Pigment	0.1	4.0	11.1	0.7	0.7	-3.3
Medication for hormone replacement therapy	0.1	0.1	0.2	0.4	0.3	0.1
Medication: Levothyroxine sodium	0.1	0.1	0.2	-0.4	0.1	0.3
Allergy	0.1	0.2	0.4	-0.6	-0.3	0.0
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.1	0.3	-0.4	0.3
Standing height	0.1	0.9	1.8	0.9	1.4	-0.2
Headache pain in last month	0.1	0.2	0.6	-0.3	-0.8	-0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	-0.6	0.1	0.3
Number of full brothers	0.1	0.1	0.3	0.2	0.5	-0.3
Wheeze or whistling in the chest in last year	0.1	0.1	0.4	0.2	0.0	0.6
Shortness of breath walking on level ground	0.1	0.1	0.3	0.0	-0.3	-0.5
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.0	0.4	0.3
Medication for pain relief, constipation, heartburn	0.1	0.1	0.4	0.6	0.1	0.1
Medication: Omeprazole	0.1	0.2	0.2	-0.5	-0.4	0.2
Mean time to correctly identify matches	0.1	0.1	0.3	0.5	0.1	0.2
Arm predicted mass (right)	0.1	0.7	1.4	1.2	0.8	-0.1
Comparative height size at age 10	0.1	0.8	2.1	-0.1	-0.4	-1.5
Illnesses of father: Heart disease	0.1	0.2	0.2	-0.5	-0.4	-0.3
Friendships satisfaction	0.1	0.1	0.4	0.6	-0.0	-0.1
Back pain experienced in last month	0.1	0.2	0.6	-0.1	-0.8	-0.2
Wears glasses or contact lenses	0.1	0.1	0.2	0.0	-0.1	-0.5
Eye problems/disorders: Glaucoma	0.1	0.2	0.4	0.3	0.6	0.0
Alcohol drinker status: Never	0.1	0.1	0.2	0.4	-0.2	0.5
Ever smoked	0.1	0.2	0.5	-0.7	0.0	0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.4	0.3	0.0	0.6
Pain experienced in last month	0.1	0.1	0.3	-0.4	0.1	-0.5
Heart disease (siblings)	0.1	0.2	0.5	-0.7	-0.1	0.0
Impedance of whole body	0.1	0.5	0.6	-0.7	0.7	0.8
Age at First Birth	0.0	0.0	0.1	-0.3	0.1	0.1
Smoking Status	0.0	0.1	0.2	-0.4	0.1	0.2
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.2	0.1	0.1	0.4
Fed-up feelings	0.0	0.1	0.1	-0.2	-0.3	0.1
Sitting height	0.0	0.2	0.7	0.1	0.8	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	-0.3	-0.1	-0.2
Alcohol intake versus 10 years previously	0.0	0.0	0.0	-0.1	0.2	-0.2
Birth weight of first child	0.0	0.1	0.2	-0.1	0.0	0.5
Number of children fathered	0.0	0.0	0.1	0.3	-0.2	-0.1
Heart disease (mother)	0.0	0.0	0.0	-0.1	0.0	0.0
Ever had bowel cancer screening	0.0	0.0	0.1	-0.2	0.2	0.0
Illnesses of father: None of the above (group 1)	0.0	0.0	0.0	-0.1	0.1	-0.2

Hub : Genes

PRSS3

Models

Trait associations