TWAS hub - NCOA4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Atrial Appendage	0.1550	0.0660	0.00380	-0.004	NA	-0.004	NA	-0.003	5.7e-01	NA	5.6e-01	NA	4.5e-01
2	GTEx	Prostate	0.1980	0.0840	0.00370	0.181	NA	0.117	NA	0.164	2.6e-05	NA	7.6e-04	NA	6.4e-05
3	NTR	Blood	0.0209	0.0098	0.00076	0.012	0.009	0.010	0.010	0.009	6.0e-05	4.7e-04	2.6e-04	2.9e-04	3.9e-04
4	YFS	Blood	0.1517	0.0312	0.00000	0.150	0.154	0.173	0.174	0.178	1.0e-46	4.7e-48	2.4e-54	1.9e-54	9.5e-56
5	TCGA	Prostate Adenocarcinoma	0.0525	0.0473	0.00710	0.012	0.020	0.025	NA	0.016	1.6e-02	3.3e-03	1.1e-03	NA	6.7e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Prostate Cancer	113.3	159.3	302.8	-1.2	17.4	-15.1	-13.2	9.5
Allergy or Eczema	6.7	17.7	34.6	-2.2	5.9	-5.0	-4.9	0.7
Hayfever, allergic rhinitis or eczema	4.6	10.0	20.1	-1.5	4.5	-4.0	-3.4	0.2
Hayfever/allergic rhinitis (self-reported)	4.1	5.4	8.4	-1.9	2.9	-2.5	-2.8	-0.8
Allergy	3.1	7.1	13.2	2.2	-3.6	3.1	2.6	1.1
Medication: Ramipril	2.8	3.6	8.7	0.7	-2.9	1.9	1.9	-1.3
Mineral and other dietary supplements	2.8	3.7	7.8	0.1	2.7	-2.8	-1.9	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.6	3.1	4.5	0.8	-2.1	2.0	1.6	-1.9
Had menopause	2.4	3.0	6.3	-2.5	-1.0	1.3	1.8	-1.7
Eye problems/disorders: Diabetes related eye disease	2.3	2.6	9.9	-3.1	-0.3	1.2	0.5	-1.1
Pain all over the body in last month	2.2	2.3	6.3	0.9	1.4	-1.1	-1.3	2.5
Happiness	2.2	2.7	5.2	1.0	1.7	-2.2	-2.3	0.3
Vitamin and mineral supplements	2.1	2.9	5.9	-0.8	2.4	-2.3	-1.5	0.2
Ever had prostate specific antigen (PSA) test	2.1	2.5	5.4	-1.1	2.0	-1.4	-2.3	-0.2
Hair/balding pattern: Pattern 2	1.9	2.5	7.1	1.2	0.8	-1.2	-1.3	2.7
Ever highly irritable/argumentative for 2 days	1.9	2.3	4.9	1.8	-1.7	-0.3	0.8	-2.2
Loud music exposure frequency	1.9	2.1	3.6	0.7	-1.9	1.9	1.5	-0.9
Blood clot in the leg (DVT)	1.9	2.4	5.1	0.3	-1.8	1.5	1.3	-2.2
Wheeze or whistling in the chest in last year	1.9	3.4	6.5	-2.6	-0.8	1.6	1.6	-2.1
Mother’s age at death	1.8	2.3	3.6	-1.4	-1.5	1.6	1.1	-1.9
Bipolar Disorder (2018)	1.7	2.6	6.3	1.6	1.6	-2.5	-1.3	0.0
Father’s age at death	1.7	2.3	4.1	1.1	-1.8	1.6	2.0	-0.3
Emphysema/chronic bronchitis	1.7	1.9	4.2	-2.1	1.6	-0.8	-0.8	-1.2
Long-standing illness, disability or infirmity	1.7	2.5	4.7	-2.1	-0.6	1.5	1.0	-2.2
Osteoarthritis (self-reported)	1.7	2.2	9.6	-3.1	0.9	0.1	-0.5	-0.4
Miserableness	1.7	2.9	7.1	2.0	0.6	-2.7	-1.8	0.1
Eye problems/disorders: Glaucoma	1.7	2.0	5.1	-1.8	1.1	-0.4	-2.3	-0.2
Ovarian Cancer	1.5	2.0	3.0	1.0	1.1	-1.5	-1.7	1.6
Bipolar Disorder (2011)	1.5	1.4	5.2	0.0	1.4	-2.3	0.0	0.0
Qualifications: CSEs or equivalent	1.5	2.0	5.2	0.6	2.3	-2.0	-0.7	-0.1
Neck or shoulder pain in last month	1.5	2.2	4.9	-1.4	-1.3	2.2	0.8	-1.3
Mood swings	1.5	2.8	6.3	1.5	1.7	-2.5	-1.6	0.0
Unable to work because of sickness or disability	1.5	1.9	4.3	-1.5	-0.6	1.6	2.1	-0.1
Alcohol drinker status: Previous	1.5	1.7	5.8	-0.4	2.4	-1.4	-0.8	-0.2
Primary Biliary Cirrhosis	1.4	2.0	5.3	-2.1	2.3	-0.6	-0.0	0.0
Medication: Lansoprazole	1.4	1.6	3.5	0.2	-1.3	1.9	1.5	0.7
Pulse wave Arterial Stiffness index	1.4	1.6	4.9	-2.2	-0.8	1.5	0.6	0.0
Pulse wave peak to peak time	1.4	1.6	3.7	1.9	1.1	-1.6	-0.7	0.2
Mouth/teeth dental problems: Loose teeth	1.4	1.6	2.5	1.5	-0.6	1.3	1.6	1.1
Leg fat-free mass (right)	1.4	7.5	14.5	-2.2	3.7	-1.8	-3.8	1.1
Ever had bowel cancer screening	1.4	1.6	3.5	-1.9	-0.7	1.4	1.5	0.2
Leg predicted mass (right)	1.4	7.3	14.4	-2.2	3.6	-1.7	-3.8	1.1
Blood Red Count	1.3	12.3	24.9	-3.7	3.3	-2.5	-5.0	-2.3
Hearing difficulty/problems: Yes	1.3	2.0	7.1	-2.7	0.2	1.4	0.6	-0.6
Impedance of leg (right)	1.3	6.3	14.8	2.2	-3.0	1.6	3.9	-1.0
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	4.0	1.0	1.9	-2.0	-0.9	1.0
Depression (self-reported)	1.3	1.6	5.5	-0.0	0.1	-1.3	-0.8	-2.4
Shortness of breath walking on level ground	1.3	1.5	3.6	0.9	-1.1	0.5	1.3	-1.9
Had major operations	1.3	1.5	3.5	-0.3	1.2	-1.2	-1.9	0.9
Friendships satisfaction	1.3	1.6	3.4	1.3	0.7	-1.1	-1.0	1.8
Commuting to job workplace: Walk	1.3	1.4	2.5	0.8	-1.6	1.1	1.6	-0.5
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	4.4	0.5	-1.3	1.0	0.9	-2.1
Alzheimer’s Disease (in mother)	1.2	1.4	3.8	0.4	0.8	-1.0	-1.9	1.1
Leg fat-free mass (left)	1.2	6.4	13.6	-2.0	3.4	-1.6	-3.7	0.8
Leg predicted mass (left)	1.2	6.2	13.0	-1.9	3.3	-1.6	-3.6	0.8
Number of live births	1.2	1.6	3.5	-0.5	-1.9	0.9	1.8	-0.5
High blood pressure (siblings)	1.2	1.7	5.2	-2.3	1.4	-0.9	-0.6	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.0	0.4	1.7	-1.3	-1.0	0.8
Osteoporosis (self-reported)	1.2	1.5	3.9	-0.9	-1.0	2.0	1.3	0.3
Medication: Gliclazide	1.2	1.3	3.3	-1.8	-0.3	1.4	1.1	0.4
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.3	-0.3	-0.7	1.0	1.6	-1.8
Ever depressed for a whole week	1.2	1.5	6.2	2.5	-0.9	-0.1	0.1	-0.8
Fasting Glucose	1.1	1.3	2.0	-1.3	1.1	1.1	-0.4	-1.4
Frequency of depressed mood in last 2 weeks	1.1	1.6	3.9	0.2	1.2	-2.0	-1.3	-0.8
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	5.2	-2.3	1.4	-0.2	0.1	-0.1
Ever had hysterectomy (womb removed)	1.1	1.3	4.0	-0.5	0.7	-1.2	-0.1	-2.0
Relative age voice broke	1.1	1.6	2.7	0.1	-1.4	1.1	1.7	-1.5
Stomach or abdominal pain in last month	1.1	1.3	2.0	-0.8	-1.4	0.6	1.4	-1.3
Impedance of leg (left)	1.1	5.5	14.6	1.9	-2.6	1.4	3.8	-0.7
Nervous feelings	1.1	2.1	4.5	1.0	1.5	-2.1	-0.9	1.3
Time employed in main current job	1.1	1.3	2.9	-1.7	1.1	-0.2	-0.7	1.3
Worrier / anxious feelings	1.1	2.1	5.8	2.4	-0.1	-1.9	-0.2	0.9
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	1.9	0.9	1.2	-1.4	-1.1	1.3
Medication: Cholesterol lowering	1.1	1.7	3.2	-1.0	-1.0	1.7	1.8	-0.4
Worry too long after embarrassment	1.1	1.9	4.3	0.8	1.5	-2.1	-1.0	1.0
Medication: Aspirin	1.1	1.5	4.9	-2.2	1.2	0.0	-1.0	-0.4
Loneliness, isolation	1.1	1.5	4.7	0.9	0.1	-1.4	-0.0	-2.2
Eye problems/disorders: Cataract	1.1	1.3	2.8	0.2	-0.6	1.2	1.7	-1.3
Commuting to job workplace: Cycle	1.1	1.3	6.1	0.3	0.4	0.1	-0.4	2.5
Mean Putamen Volume	1.0	1.2	3.0	1.7	0.2	-1.3	-0.3	-1.0
Fed-up feelings	1.0	1.9	5.0	1.1	1.1	-2.2	-1.0	-1.0
Medication: Simvastatin	1.0	1.5	3.4	-0.5	-1.1	1.8	1.5	0.4
Illnesses of siblings	1.0	1.4	4.8	2.2	-0.9	0.6	0.4	0.9
Tense / ‘highly strung’	1.0	1.7	4.5	1.6	0.9	-2.1	-0.7	0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	2.9	-0.6	-1.3	0.5	0.7	-1.7
Age at first live birth	1.0	1.8	6.9	1.0	1.0	-0.1	-2.6	0.5
Eye problems/disorders: None of the above	1.0	1.1	2.3	1.5	-1.4	0.1	1.2	0.1
Medication for pain relief, constipation, heartburn	1.0	1.6	4.0	0.6	-1.4	1.0	2.0	-0.8
Alcohol intake frequency.	1.0	2.3	5.5	0.8	2.3	-1.7	-0.9	1.2
Number of full sisters	1.0	1.2	3.1	-0.9	-0.5	0.7	1.7	-1.2
Whole body fat-free mass	1.0	5.7	11.1	-2.1	3.3	-1.2	-3.3	0.7
Basal metabolic rate	1.0	5.5	11.1	-1.8	3.3	-1.4	-3.3	0.8
Age at First Birth	0.9	1.3	2.9	1.7	0.1	-1.0	-1.5	0.0
Rheumatoid Arthritis	0.9	1.3	4.1	-1.5	-0.2	0.0	0.2	-2.0
Diabetes (mother)	0.9	1.2	2.0	-0.1	1.1	-1.4	-1.4	0.8
Age when periods started (menarche)	0.9	2.2	4.1	-0.6	-1.7	2.0	1.9	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.2	-1.5	0.6	0.5	-1.2	0.9
Lung cancer (father)	0.9	1.1	3.9	-0.9	-0.8	2.0	-0.1	-0.1
Birth weight	0.9	1.9	3.7	-1.0	-1.2	1.8	1.9	-0.4
Average weekly red wine intake	0.9	1.4	2.8	1.5	-1.1	0.8	0.0	-1.7
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.9	0.8	0.8	-2.0	-1.2	0.6
Smoking status: Current	0.9	1.4	2.5	1.0	-1.6	1.1	1.5	-0.2
Whole body water mass	0.9	5.3	10.5	-2.1	3.2	-1.2	-3.2	0.5
Average weekly champagne plus white wine intake	0.9	1.3	2.6	-1.2	1.2	-0.8	-1.6	0.5
Hearing aid user	0.9	1.0	2.5	-0.7	-0.4	1.6	-0.5	-1.2
Commuting to job workplace: Public transport	0.9	1.1	2.7	1.6	0.3	-1.4	-0.7	0.3
Supplements: Fish oil (including cod liver oil)	0.9	1.1	3.6	-0.5	-1.2	1.9	0.6	0.0
Age started oral contraceptive pill	0.9	1.1	2.8	0.4	-1.7	0.7	1.2	-0.7
Cholesterol lowering medication	0.9	1.4	2.7	0.7	-1.6	1.6	1.0	0.4
Depressed Affect (Nagel 2018)	0.8	1.7	3.4	1.0	0.4	-1.8	-1.1	-1.7
Depression (Nagel 2018)	0.8	1.1	1.8	-1.0	1.1	-1.3	-1.0	-0.7
Schizophrenia (2018)	0.8	1.6	3.3	1.0	-1.8	1.5	1.1	0.0
HDL Cholesterol	0.8	1.4	2.9	-0.8	-1.0	1.6	1.7	0.0
Average weekly spirits intake	0.8	1.0	3.4	1.8	-1.1	-0.2	0.3	-0.2
Ever used hormone-replacement therapy (HRT)	0.8	1.1	2.7	1.6	-0.8	-0.2	1.4	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	3.0	-1.0	0.4	-0.7	-0.7	-1.7
Multivitamins +/- minerals	0.8	1.0	2.0	0.7	-1.3	1.4	0.2	-1.0
Medication: Levothyroxine sodium	0.8	1.4	3.4	0.5	-1.9	1.0	1.1	-1.1
Neuroticism score	0.8	1.7	5.2	1.0	1.1	-2.3	-1.2	-0.1
Weight	0.8	3.9	9.1	-1.3	2.6	-1.3	-3.0	0.7
Trunk fat-free mass	0.8	4.6	9.0	-2.0	3.0	-0.8	-3.0	0.7
Hip circumference	0.8	3.2	8.5	-1.2	2.2	-0.8	-2.9	0.9
Hair/balding pattern: Pattern 3	0.8	1.2	2.8	-1.7	-0.4	1.7	0.4	0.0
Pulse rate	0.8	1.4	2.8	-1.7	-0.1	-0.2	1.1	-1.7
Trunk predicted mass	0.8	4.8	9.4	-2.1	3.1	-0.8	-3.0	0.7
Medication: Amlodipine	0.8	1.1	2.5	0.3	-1.6	0.9	1.3	-0.6
Comparative body size at age 10	0.8	2.3	3.5	0.3	1.6	-1.9	-1.8	-1.4
Medication: Blood pressure	0.8	1.5	2.7	0.4	-1.6	1.2	0.8	-1.5
Medication: Allopurinol	0.8	1.0	2.0	0.4	-0.5	1.4	1.4	0.9
Risk taking	0.8	1.2	2.6	-0.3	1.5	-1.0	-1.6	-0.1
Heart disease (siblings)	0.8	0.9	1.4	-1.2	-0.2	1.1	0.9	-1.2
Arm predicted mass (left)	0.8	4.1	8.7	-2.1	2.9	-1.0	-2.5	0.7
Intelligence (Savage-Jansen 2018)	0.7	2.1	4.6	-1.6	0.2	0.1	-2.1	-1.8
Ulcerative Colitis	0.7	1.0	1.9	1.4	0.6	-1.1	-1.2	0.0
Respiratory disease	0.7	1.5	4.4	-2.1	1.3	-0.4	-0.7	-0.8
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	1.6	0.1	1.0	-1.2	-1.2	0.5
Fluid intelligence score	0.7	1.4	3.2	-1.8	-0.5	0.9	-1.1	-1.1
Alcohol intake versus 10 years previously	0.7	1.0	3.3	1.1	-0.2	-0.6	-0.3	1.8
Falls in the last year	0.7	1.0	2.3	-0.2	-1.2	1.5	1.0	-0.5
Noisy workplace	0.7	0.9	1.6	1.1	-0.4	1.0	1.3	0.7
Prospective memory result	0.7	0.8	1.4	0.9	-1.2	0.8	1.1	-0.2
Exposure to tobacco smoke at home	0.7	0.8	1.9	1.4	-0.6	-0.3	1.1	-0.4
Hair/balding pattern: Pattern 4	0.7	1.8	4.6	-2.1	0.0	-0.0	0.2	-2.1
Glaucoma (self-reported)	0.7	0.9	1.9	-1.4	-0.7	1.4	-0.3	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	3.9	0.3	-0.4	-0.3	0.3	-2.0
Overall health rating	0.7	1.6	4.4	-2.1	1.4	-0.2	0.2	-1.2
Family relationship satisfaction	0.7	0.9	1.6	-0.5	0.9	-0.9	-1.3	-0.9
Diabetes diagnosed by doctor	0.7	1.1	3.7	-1.9	-0.3	1.1	0.7	-0.4
Back pain experienced in last month	0.7	1.1	2.9	-1.1	-0.3	0.4	1.0	-1.7
Medication: Aspirin	0.7	0.9	3.6	-1.9	0.6	0.4	-0.4	-0.3
Arm fat-free mass (left)	0.7	3.6	7.1	-2.2	2.7	-0.6	-2.3	0.4
Diastolic blood pressure, automated reading	0.7	2.2	3.9	-0.7	2.0	-1.7	-1.6	-1.1
Pack years of smoking	0.7	1.0	1.6	-0.1	-0.8	1.1	1.3	-1.2
Impedance of whole body	0.7	3.6	9.5	1.6	-2.2	0.9	3.1	-0.3
HbA1C	0.6	0.6	1.4	-1.2	1.0	-0.6	0.6	0.0
LDL Cholesterol	0.6	0.9	2.4	1.5	0.8	-1.0	-0.9	0.0
Schizophrenia (2014)	0.6	1.3	2.3	1.0	-1.5	1.1	1.1	0.8
Lung FVC	0.6	3.1	6.4	1.7	-2.5	0.6	1.9	-1.6
Severe depression (siblings)	0.6	0.6	1.4	-1.2	0.3	-0.4	0.6	-1.1
Townsend deprivation index at recruitment	0.6	0.8	2.4	1.6	0.5	-1.1	0.4	-0.3
Taking other prescription medications	0.6	0.9	2.1	-0.8	-0.9	0.6	0.8	-1.5
Supplements: Glucosamine	0.6	0.8	1.7	0.3	-1.2	1.3	-0.6	-0.4
Medication: Atenolol	0.6	0.8	2.0	-0.2	-1.4	1.0	0.7	-0.8
Arm fat mass (right)	0.6	2.4	5.9	-0.5	2.0	-1.0	-2.4	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.3	0.9	0.4	-1.5	-0.4	-1.2
Gout (self-reported)	0.6	0.8	1.6	0.8	1.0	-0.1	-0.8	1.3
Qualifications: College or University degree	0.6	2.0	5.0	1.3	0.8	-1.7	-2.2	-0.1
Medication: Ibuprofen	0.6	0.7	1.1	0.5	1.1	-1.0	-0.8	0.6
Arm predicted mass (right)	0.6	3.0	5.3	-2.3	2.3	-0.4	-2.1	0.3
Leg pain on walking	0.6	0.7	1.9	1.2	0.0	0.1	1.4	-0.3
Illnesses of father: Heart disease	0.6	0.9	3.5	-1.9	0.5	-0.2	-0.7	-0.1
Financial situation satisfaction	0.6	0.8	1.8	1.1	0.4	-1.3	-0.4	-0.7
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.2	-0.4	-0.7	0.9	0.1	-1.5
Basal cell carcinoma (self-reported)	0.6	0.8	1.7	-0.9	-1.0	1.3	0.5	-0.2
Lupus	0.5	0.7	2.2	0.1	-0.5	1.0	1.5	-0.3
Neuroticism (2016)	0.5	0.7	2.1	0.5	-0.7	-0.5	1.4	-0.6
Relative age of first facial hair	0.5	1.1	3.6	-1.3	0.0	-0.3	0.1	-1.9
Average weekly fortified wine intake	0.5	0.6	3.1	1.8	-0.2	-0.0	0.0	0.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.5	0.2	0.8	-1.2	-0.7	0.1
Chronic bronchitis/emphysema (father)	0.5	0.5	1.1	0.4	-1.1	0.6	1.0	-0.1
Body mass index (BMI)	0.5	2.3	6.8	-0.7	1.8	-1.1	-2.6	0.5
Number of incorrect matches in round	0.5	0.9	2.5	0.6	-0.6	1.1	1.6	-0.4
Past tobacco smoking	0.5	1.0	2.7	-0.1	1.7	-1.2	-0.8	0.2
Had other major operations	0.5	0.6	1.8	-0.4	-0.9	1.3	-0.2	-0.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.1	1.1	-0.7	0.1	0.7	-1.1
Arm fat percentage (right)	0.5	1.9	4.9	-0.1	1.7	-1.2	-2.2	0.6
Breastfed as a baby	0.5	0.6	1.6	0.3	0.6	-0.4	-1.3	-1.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.1	-0.7	0.6	-0.3	-0.5	1.4
Arm fat-free mass (right)	0.5	2.7	5.0	-2.2	2.2	-0.3	-1.9	0.1
Number of children fathered	0.5	0.6	2.1	-1.4	0.4	0.7	-0.5	-0.1
Medication: Seretide 50 evohaler	0.5	0.6	2.5	-0.4	-0.3	0.1	-0.1	-1.6
Mean time to correctly identify matches	0.5	0.9	1.6	-0.3	-1.3	1.1	1.1	0.5
Comparative height size at age 10	0.5	3.0	6.2	-2.3	2.5	-1.0	-1.0	1.4
Suffer from ‘nerves’	0.5	0.7	1.5	1.2	-0.8	0.4	1.2	-0.3
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.0	1.0	0.4	-0.9	-0.8	0.7
Arm fat mass (left)	0.5	1.9	5.2	-0.8	1.8	-0.7	-2.3	0.5
Number of self-reported non-cancer illnesses	0.5	0.8	3.2	-0.6	0.4	-0.3	-0.4	-1.8
Number of operations (self-reported)	0.5	0.7	1.6	-1.1	0.5	-0.2	-1.3	-0.6
Myopia	0.5	0.8	1.9	0.2	-1.4	0.9	0.9	-0.5
Pain experienced in last month	0.5	0.8	1.8	0.9	0.9	-0.7	-0.5	1.3
Neuroticism (Nagel 2018)	0.4	1.0	2.5	0.4	0.7	-1.6	-0.6	-1.2
Ulcerative Colitis (UC)	0.4	0.7	1.7	-0.3	0.0	-1.3	-1.3	0.1
Verbal and Numeric Reasoning (VNR)	0.4	0.8	2.4	-1.2	-0.1	0.2	-1.5	-0.7
Medication: Co-codamol	0.4	0.5	1.3	-0.8	-0.0	1.1	0.5	0.2
Diabetes (father)	0.4	0.5	0.9	-0.5	-0.6	1.0	0.2	-0.8
Current tobacco smoking	0.4	0.7	1.2	1.1	-1.0	0.6	0.9	0.2
Serious illness, injury or assault to yourself	0.4	0.5	1.2	-0.7	0.4	0.7	0.1	-1.1
High blood pressure (mother)	0.4	0.5	1.1	-0.4	1.0	-0.6	0.1	1.0
Trunk fat mass	0.4	1.5	3.2	-0.9	1.7	-0.7	-1.8	0.6
Waist circumference	0.4	1.3	3.5	-1.4	1.1	0.1	-1.9	-0.1
Hearing difficulty/problems with background noise	0.4	0.7	2.0	-1.4	0.5	-0.2	0.4	0.9
Heart attack	0.4	0.5	1.3	-0.5	-0.4	0.1	0.9	-1.1
Asthma	0.4	0.8	1.9	-1.1	-0.6	0.5	0.4	-1.4
Impedance of arm (left)	0.4	1.9	3.6	1.5	-1.8	0.6	1.9	-0.3
Length of working week for main job	0.4	0.4	1.4	-1.2	0.3	0.3	0.5	-0.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.5	-1.2	-0.2	0.6	0.4	1.2
Medication: Paracetamol	0.4	0.6	1.4	0.7	0.2	-1.0	-1.2	0.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.5	0.8	-1.2	0.4	0.9	-0.6
Age at last live birth	0.4	0.6	3.1	0.1	0.2	0.2	-1.8	0.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.8	0.4	-1.4	0.5	0.6	-0.4
Asthma (self-reported)	0.4	0.8	2.0	-1.3	-0.4	0.5	0.4	-1.4
Ever taken oral contraceptive pill	0.4	0.4	0.7	-0.0	-0.8	0.8	0.4	0.7
Alcohol drinker status: Never	0.4	0.4	0.8	0.3	-0.3	0.7	0.9	-0.8
Fractured/broken bones in last 5 years	0.4	0.5	1.2	1.1	0.4	-0.5	0.0	-0.8
Supplements: Calcium	0.4	0.4	0.9	-0.7	0.6	-1.0	-0.3	-0.6
Bipolar Disorder or Schizophrenia	0.3	0.6	2.8	1.7	-0.4	-0.4	0.0	0.0
Alzheimer’s Disease (in father)	0.3	0.4	0.6	-0.8	-0.8	0.3	-0.1	-0.7
Alzheimer’s Disease (including proxy)	0.3	0.4	1.1	-0.3	0.3	-0.7	-1.1	0.5
Reaction Time	0.3	0.5	1.1	0.2	-0.9	0.8	0.3	1.0
Body Mass Index (BMI) (2010)	0.3	0.5	1.5	-0.4	1.2	-0.5	-0.6	0.0
Coronary Artery Disease (CAD)	0.3	0.3	0.7	-0.6	-0.8	0.7	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.7	0.8	0.7	-0.8	-0.1	0.0
Blood Eosinophil Count	0.3	2.6	3.8	-1.5	-1.4	1.6	-1.5	-1.9
Blood White Count	0.3	2.3	9.5	-0.3	0.6	-0.4	-3.1	-1.1
Lung FEV1/FVC ratio	0.3	1.4	2.9	-0.6	1.6	-0.1	-0.9	1.7
Systolic blood pressure, automated reading	0.3	0.8	1.8	-1.0	-0.4	1.1	0.4	-1.3
Supplements: Zinc	0.3	0.3	0.7	0.2	-0.9	0.3	0.6	0.4
Medication: Metformin	0.3	0.4	0.8	-0.9	-0.4	0.8	0.8	0.2
Pack years adult smoking proportion	0.3	0.5	0.6	0.6	-0.7	0.8	0.8	-0.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.2	-1.1	0.1	-0.4	0.0	0.0
Alcohol usually taken with meals	0.3	0.5	2.2	-0.2	-0.5	1.5	-0.1	-0.2
Financial difficulties in last 2 years	0.3	0.5	1.3	-0.5	-0.2	-0.3	0.8	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.3	0.5	1.1	-1.5	-0.8	0.5
Birth weight of first child	0.3	0.6	1.6	1.3	-0.7	0.3	-0.8	-0.5
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	1.2	-0.1	0.7	-1.1	-1.0	0.4
Number of full brothers	0.3	0.4	0.7	-0.7	0.4	0.6	0.5	-0.9
Whole body fat mass	0.3	1.3	3.2	-0.9	1.5	-0.6	-1.8	0.2
Leg fat mass (right)	0.3	1.0	2.9	-0.5	1.3	-0.4	-1.7	0.3
Knee pain experienced in last month	0.3	0.5	1.0	-0.9	0.6	-0.3	0.0	1.0
Illnesses of siblings: Diabetes	0.3	0.4	0.7	-0.7	-0.5	0.5	0.3	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.8	-1.3	0.8	0.3	-0.5	0.2
Arm fat percentage (left)	0.3	1.1	3.5	-0.2	1.2	-0.8	-1.9	0.3
Illnesses of father: None of the above (group 1)	0.3	0.4	0.8	0.8	-0.1	0.5	0.9	0.5
Guilty feelings	0.3	0.4	2.0	0.2	0.1	-0.2	-0.2	-1.4
Wears glasses or contact lenses	0.3	0.4	0.9	-0.7	-0.8	0.9	-0.2	-0.2
Medication: Paracetamol	0.3	0.5	1.0	0.5	0.3	-0.9	-1.0	-0.4
Ever smoked	0.3	0.6	1.7	0.6	-1.3	0.9	0.1	0.3
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.2	-0.4	-0.1	-0.3	0.8	-1.1
Leg fat mass (left)	0.3	1.3	3.4	-0.6	1.5	-0.6	-1.8	0.2
Worry (Nagel 2018)	0.2	0.5	0.7	0.8	0.1	-0.7	0.9	0.8
Crohns Disease (2017)	0.2	0.4	1.5	0.5	-1.2	0.6	0.1	-0.2
Breast Cancer	0.2	0.5	1.3	-0.2	-0.7	-0.5	-0.7	-1.1
Crohns Disease (2012)	0.2	0.3	0.7	0.5	0.2	-0.8	-0.8	0.0
Blood Platelet Count	0.2	2.4	7.3	0.7	0.8	-1.8	-2.7	0.5
BMI	0.2	1.4	3.2	-1.5	1.2	-0.2	-1.8	0.4
Smoking Status	0.2	0.6	1.4	0.2	-1.2	0.8	0.7	-0.6
Hypothyroidism (self reported)	0.2	0.5	2.2	1.5	0.0	-0.3	0.3	0.2
Neuroticism	0.2	0.5	1.0	0.1	0.7	-1.0	-0.6	-0.8
Chronotype (morning person)	0.2	0.6	1.9	-0.3	-0.4	0.3	0.7	1.4
Sensitivity / hurt feelings	0.2	0.4	1.0	-0.5	0.6	-0.5	-1.0	0.0
Maternal smoking around birth	0.2	0.4	0.9	-0.3	-1.0	-0.2	0.8	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.1	-1.5	0.2	0.7	-0.3	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.8	0.3	0.6	-0.9	-0.1	0.7
Forced vital capacity (FVC)	0.2	0.6	1.6	0.4	0.3	-1.1	0.3	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.6	-1.2	0.2	0.4	-0.4	0.2
Diabetes (self-reported)	0.2	0.3	0.9	-0.9	-0.2	0.7	0.4	-0.1
Impedance of arm (right)	0.2	1.0	3.2	1.8	-0.6	-0.3	1.0	0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.5	0.5	0.8	-1.2	-0.2	-0.3
Illnesses of mother	0.2	0.3	0.7	0.8	-0.4	-0.3	0.4	0.5
Standing height	0.2	1.6	3.4	-1.5	1.8	-0.5	-1.3	0.6
Pulse wave reflection index	0.2	0.2	0.9	-1.0	0.0	0.2	-0.2	0.3
Headache pain in last month	0.2	0.3	1.1	0.3	0.4	-0.6	0.0	-1.0
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.6	0.5	-0.5	-0.0	0.8	-0.2
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.3	0.2	-0.5	0.5	0.5	-0.4
Health satisfaction	0.2	0.2	0.5	0.2	0.2	0.2	0.6	0.7
Migraine (self-reported)	0.2	0.3	0.6	-0.3	-0.7	0.4	0.4	-0.7
Medication: Omeprazole	0.2	0.2	0.6	0.6	0.2	-0.1	-0.2	0.8
Chest pain or discomfort	0.2	0.3	0.8	-0.4	0.5	-0.6	-0.1	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.7	0.5	-0.3	0.2	0.7	0.8
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.1	-1.0	0.3	0.1	-0.1	-0.1
Supplements: Vitamin C	0.2	0.2	0.5	-0.2	-0.7	0.5	0.0	0.6
Qualifications: nursing, teaching	0.2	0.4	0.9	0.9	-0.3	-0.2	-0.9	-0.3
Medication for cholesterol	0.2	0.3	1.2	0.2	-0.2	0.1	-0.5	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	-0.6	-0.1	0.6	0.6	0.1
Breast cancer (self-reported)	0.2	0.2	0.8	-0.2	0.1	0.9	0.6	0.2
Medication: Lisinopril	0.2	0.3	0.4	0.6	0.3	-0.5	0.3	0.6
Medication: Atorvastatin	0.2	0.3	0.7	0.3	-0.7	0.3	0.8	0.2
Illnesses of father: High blood pressure	0.2	0.2	0.8	-0.9	0.1	-0.5	-0.2	0.1
Average weekly beer plus cider intake	0.2	0.3	0.7	-0.7	-0.5	0.3	0.8	0.1
Irritability	0.2	0.4	0.6	-0.7	0.4	-0.8	-0.8	0.4
Schizophrenia vs Biploar Disorder	0.1	0.1	0.4	0.0	-0.7	0.4	0.0	0.0
Irritable Bowel Disease (IBD)	0.1	0.2	0.8	-0.0	-0.9	-0.2	-0.5	-0.1
Triglycerides	0.1	0.2	0.5	-0.2	0.4	-0.7	-0.7	0.0
Heel T-Score	0.1	0.6	2.9	-1.7	-0.0	0.3	-0.2	0.1
Height	0.1	2.4	9.2	-3.0	0.6	1.2	0.3	-0.9
Waist Hip Ratio (WHR)	0.1	0.5	1.1	0.4	-1.0	0.7	1.0	0.3
Systolic Blood Pressure	0.1	0.3	1.1	0.2	0.5	-0.2	0.2	-1.1
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.5	-0.3	0.0	-0.0	0.1	0.7
Tanning	0.1	0.8	2.9	1.7	-0.8	0.3	0.6	0.0
Hand grip strength (left)	0.1	0.2	0.3	-0.6	-0.1	0.3	0.6	-0.5
Number of treatments/medications taken	0.1	0.2	1.1	-1.0	0.0	-0.1	-0.1	-0.3
Medication for hormone replacement therapy	0.1	0.1	0.6	0.1	0.3	-0.2	0.8	0.1
Trunk fat percentage	0.1	0.6	1.2	-0.4	1.0	-0.5	-1.1	0.6
Hand grip strength (right)	0.1	0.3	0.5	-0.7	-0.5	0.7	0.4	0.0
High blood pressure	0.1	0.2	0.6	-0.3	0.7	-0.3	-0.5	-0.5
Sitting height	0.1	0.5	1.9	-1.4	0.6	0.6	0.1	0.1
Qualifications: None of the above	0.1	0.2	0.5	0.7	-0.1	0.0	0.5	-0.4
Mouth/teeth dental problems	0.1	0.2	0.7	0.1	-0.4	0.2	-0.2	-0.8
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.1	-0.3	-0.3	0.4	0.1	-1.0
Mouth/teeth dental problems: Dentures	0.1	0.2	0.5	-0.4	0.4	-0.2	0.7	0.0
Peak expiratory flow (PEF)	0.1	0.2	0.4	0.6	-0.1	-0.1	0.3	-0.6
Forced vital capacity (FVC), Best measure	0.1	0.4	1.5	0.6	0.5	-1.2	-0.5	-0.0
Body fat percentage	0.1	0.4	1.1	-0.2	0.8	-0.5	-1.1	0.1
Leg fat percentage (right)	0.1	0.2	0.6	0.3	0.4	-0.2	-0.8	-0.3
Exposure to tobacco smoke outside home	0.1	0.1	0.3	0.4	-0.1	-0.5	0.4	0.3
Heart disease (mother)	0.1	0.1	0.3	-0.6	0.4	0.2	0.3	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.5	0.7	0.2	0.1	0.4	0.1
Pulse rate, automated reading	0.1	0.3	1.0	-0.3	-0.4	0.5	1.0	-0.3
Smoking status: Previous	0.1	0.1	0.2	0.4	-0.5	0.3	0.0	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.7	0.8	-0.1	-0.6	0.1	-0.3
Medication: Blood pressure	0.1	0.2	0.3	-0.6	0.2	0.4	0.5	0.4
High cholesterol (Self-reported)	0.1	0.2	0.3	0.2	-0.5	0.5	0.4	0.4
Medication: Bendroflumethiazide	0.1	0.2	0.6	-0.3	0.8	-0.1	-0.2	-0.1
Leg fat percentage (left)	0.1	0.2	0.6	0.2	0.5	-0.3	-0.8	-0.3
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.5	0.4	-0.6	0.2	0.4	0.7
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.4	0.2	-0.1	0.6	-0.2	0.4
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Cardiovascular Disease	0.0	0.1	0.3	-0.0	0.6	0.2	0.1	0.4
Hair Pigment	0.0	0.4	0.7	-0.1	-0.9	0.6	0.3	-0.8
Angina	0.0	0.0	0.1	0.1	-0.2	-0.1	0.1	-0.3
Angina (self-reported)	0.0	0.0	0.1	-0.3	-0.2	-0.0	0.1	-0.3
Hypertension (Self-reported)	0.0	0.1	0.4	-0.4	0.6	-0.1	-0.1	0.2

Hub : Genes

NCOA4

Models

Trait associations