TWAS hub - CHMP2B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0834	0.0329	1.0e-03	0.093	NA	0.066	NA	0.078	9.6e-08	NA	7.1e-06	NA	1.1e-06
2	GTEx	Esophagus Mucosa	0.1750	0.0510	3.2e-07	0.116	NA	0.155	NA	0.148	3.8e-08	NA	1.6e-10	NA	4.0e-10
3	GTEx	Nerve Tibial	0.0624	0.0315	6.5e-03	0.027	NA	0.007	NA	0.023	4.8e-03	NA	1.0e-01	NA	8.5e-03
4	METSIM	Adipose	0.0651	0.0242	3.0e-04	0.037	0.020	0.015	0.021	0.026	2.5e-06	4.0e-04	2.1e-03	3.3e-04	7.5e-05
5	YFS	Blood	0.2295	0.0380	0.0e+00	0.106	0.152	0.163	0.138	0.155	6.4e-33	2.4e-47	5.4e-51	7.8e-43	2.2e-48
6	TCGA	Bladder Urothelial Carcinoma	0.0350	0.0230	9.4e-03	0.008	0.017	0.004	NA	0.007	6.7e-02	1.3e-02	1.4e-01	NA	7.7e-02
7	TCGA	Breast Invasive Carcinoma	0.1153	0.0434	2.1e-11	0.058	0.049	0.046	NA	0.049	5.7e-12	2.3e-10	1.1e-09	NA	2.1e-10
8	TCGA	Cervical Squamous Cell Carcinoma	0.0810	0.0460	2.4e-03	0.045	0.053	0.040	NA	0.039	3.0e-03	1.3e-03	4.6e-03	NA	5.0e-03
9	TCGA	Head and Neck Squamous Cell Carcinoma	0.0821	0.0372	6.4e-06	0.016	0.039	0.035	NA	0.033	6.0e-03	3.1e-05	6.7e-05	NA	1.1e-04
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0983	0.0472	8.4e-06	0.036	0.041	0.038	NA	0.037	5.2e-05	1.9e-05	4.1e-05	NA	4.4e-05
11	TCGA	Lung Adenocarcinoma	0.0583	0.0345	7.5e-04	0.037	0.031	0.028	NA	0.039	3.5e-05	1.5e-04	2.7e-04	NA	2.1e-05
12	TCGA	Lung Squamous Cell Carcinoma	0.1815	0.0819	2.0e-08	0.102	0.083	0.076	NA	0.100	1.2e-11	1.0e-09	5.6e-09	NA	2.0e-11
13	TCGA	Thyroid Carcinoma	0.2170	0.0660	1.5e-15	0.163	0.181	0.195	NA	0.172	1.2e-15	2.2e-17	1.2e-18	NA	1.9e-16

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Prostate Cancer	11.5	16.1	64.6	4.1	7.1	4.8	8.0	7.3	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ever highly irritable/argumentative for 2 days	7.1	8.6	13.5	-2.5	-2.8	-1.6	-3.3	-3.2	-2.4	-2.6	-2.5	-3.2	-3.7	-2.9	-3.3	-3.4
Loud music exposure frequency	4.7	5.1	9.0	2.5	2.6	2.5	1.8	3.0	2.3	2.7	2.2	1.2	1.1	2.4	1.9	2.3
Breastfed as a baby	4.2	5.3	10.5	2.5	3.2	1.9	2.0	2.8	2.4	2.4	2.4	1.2	1.7	2.4	2.0	2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.2	4.9	9.9	1.7	1.6	2.2	2.9	1.5	3.1	1.3	2.4	1.5	2.3	2.3	3.0	1.8
Mother’s age at death	3.8	4.7	7.2	-2.4	-1.7	-2.0	-2.1	-2.0	-1.6	-2.6	-2.1	-2.3	-2.2	-2.4	-2.0	-2.7
Ever smoked	3.3	5.8	8.1	2.1	1.9	2.2	2.8	2.7	2.4	2.2	2.1	2.4	2.4	2.4	2.8	2.4
Average weekly spirits intake	3.2	4.0	4.8	2.0	1.9	1.6	2.1	1.9	2.0	2.1	1.9	1.8	1.6	2.2	2.1	2.2
Bipolar Disorder (2018)	3.1	4.9	6.6	2.1	1.6	2.5	2.6	1.8	2.1	2.1	2.2	2.3	1.8	2.4	2.5	2.4
Myopia	3.1	4.4	10.0	1.9	1.0	1.7	2.3	1.6	1.1	2.3	1.4	3.2	2.9	2.1	2.2	2.5
Medication: Seretide 50 evohaler	2.9	3.4	5.5	1.6	2.1	1.3	2.2	2.3	2.4	1.5	1.7	1.0	1.7	1.8	2.2	1.5
Chest pain or discomfort	2.9	4.1	8.8	1.9	2.6	2.1	2.0	2.2	3.0	1.5	2.3	0.4	1.2	2.1	2.0	1.7
Supplements: Vitamin C	2.9	3.4	7.9	1.2	2.0	0.8	2.1	2.1	1.1	1.6	0.7	2.1	2.8	1.6	2.0	2.4
Breast cancer (self-reported)	2.9	3.4	7.2	-2.5	-1.5	-2.7	-1.2	-2.0	-1.4	-2.4	-2.2	-1.1	-0.8	-2.2	-1.2	-1.7
Crohns Disease (2012)	2.7	4.4	9.6	1.9	0.5	1.7	2.5	1.2	1.7	2.3	1.8	3.1	2.4	2.1	2.4	2.4
Number of full brothers	2.6	3.3	4.7	1.2	2.0	1.2	2.1	2.2	2.1	1.6	1.2	1.7	2.1	1.6	2.1	2.1
Hair/balding pattern: Pattern 2	2.5	3.2	7.3	1.5	1.9	2.2	2.1	1.6	2.7	1.0	2.0	0.6	1.0	1.9	2.1	1.2
Illnesses of mother	2.5	3.1	6.0	1.7	1.1	1.3	1.5	2.4	0.6	2.3	1.0	2.4	1.9	1.6	1.5	2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.5	2.9	4.7	2.1	1.2	2.2	1.4	1.5	1.2	2.0	1.8	1.7	1.7	1.9	1.4	1.8
Knee pain experienced in last month	2.5	3.9	5.5	2.0	1.6	2.2	2.0	2.1	2.2	1.8	2.3	1.4	1.6	2.1	2.1	1.7
Serious illness, injury or assault to yourself	2.4	3.0	4.4	1.6	1.5	1.9	1.8	1.9	2.1	1.4	2.0	1.1	1.3	2.0	1.9	1.6
Miserableness	2.4	4.2	6.2	2.1	1.9	1.7	2.0	2.5	1.4	2.4	1.6	2.2	2.2	2.2	2.0	2.2
Medication: Co-codamol	2.3	2.6	4.0	1.3	1.2	1.1	1.9	2.0	1.6	1.5	1.2	1.8	1.6	1.6	1.9	1.9
Mouth/teeth dental problems: Bleeding gums	2.3	2.9	4.8	1.7	2.1	1.7	1.6	2.2	1.8	1.7	1.7	1.1	1.5	1.8	1.6	1.5
Age when periods started (menarche)	2.2	5.2	15.4	2.0	3.9	3.9	1.7	2.2	2.7	0.9	2.9	-0.0	1.0	2.2	1.8	0.9
Ever had hysterectomy (womb removed)	2.1	2.4	6.9	-2.0	-0.7	-2.6	-1.3	-1.0	-1.4	-1.7	-2.0	-1.1	-0.6	-1.8	-1.2	-1.3
Worrier / anxious feelings	2.1	4.0	6.2	1.8	2.4	1.8	1.9	2.5	1.6	1.9	1.6	2.0	2.1	1.9	1.9	2.3
Commuting to job workplace: Car/motor vehicle	2.1	2.4	5.1	-1.5	-0.9	-0.5	-1.5	-1.5	-0.4	-1.9	-0.9	-2.3	-2.0	-1.5	-1.5	-2.2
Commuting to job workplace: Cycle	2.1	2.6	4.4	1.7	0.5	1.3	1.7	1.2	1.3	1.7	1.7	1.9	1.5	1.8	1.7	2.1
Smoking Status	2.0	4.7	6.2	2.5	1.9	2.4	2.3	2.3	2.3	2.3	2.4	1.4	1.6	2.4	2.3	2.0
Past tobacco smoking	2.0	3.6	7.6	-1.8	-1.5	-2.0	-1.9	-2.8	-1.4	-2.0	-1.5	-2.0	-1.8	-1.8	-2.0	-1.9
Back pain experienced in last month	2.0	2.9	4.5	1.1	2.0	0.9	2.0	2.0	1.6	1.3	1.1	1.7	2.1	1.4	2.0	2.1
Exposure to tobacco smoke outside home	1.9	2.5	4.6	1.2	1.2	0.6	1.9	1.4	1.5	1.6	1.1	2.0	2.1	1.6	1.9	1.8
Ever had prostate specific antigen (PSA) test	1.9	2.2	6.0	1.1	1.6	1.5	1.9	1.2	2.5	0.7	1.8	0.6	0.8	1.4	1.9	1.2
Systolic blood pressure, automated reading	1.8	5.2	8.0	-2.8	-2.7	-2.2	-1.9	-2.4	-2.0	-2.6	-2.5	-1.5	-1.4	-2.3	-1.9	-2.7
Medication: Simvastatin	1.8	2.6	5.6	1.3	1.5	1.6	1.7	1.9	2.4	1.3	1.6	1.2	1.3	1.7	1.8	1.5
Birth weight of first child	1.8	3.3	9.8	-1.9	-3.1	-1.8	-1.5	-2.2	-1.9	-1.7	-1.6	-0.4	-1.4	-1.7	-1.5	-1.8
Headache pain in last month	1.8	3.0	5.1	2.0	1.4	2.2	1.7	1.8	1.4	2.0	1.6	1.5	1.4	1.8	1.7	1.7
Number of children fathered	1.8	2.0	5.1	1.6	1.3	2.3	1.3	0.8	1.9	0.9	2.2	0.1	0.5	1.6	1.3	0.8
Hypothyroidism (self reported)	1.7	3.8	6.5	-2.4	-2.1	-2.5	-1.6	-1.3	-1.1	-1.9	-2.4	-1.7	-2.0	-2.1	-1.6	-1.8
Angina (self-reported)	1.7	2.3	4.8	1.6	1.4	1.4	1.2	2.2	0.9	1.9	1.1	1.5	1.5	1.6	1.2	1.6
Illnesses of siblings: Diabetes	1.7	2.1	3.4	-1.8	-1.1	-1.3	-1.4	-0.6	-0.7	-1.6	-1.6	-1.7	-1.7	-1.6	-1.4	-1.6
Risk taking	1.7	2.5	5.9	1.8	1.7	2.3	1.5	0.7	1.9	1.0	2.4	0.2	1.0	1.8	1.5	0.9
Age started oral contraceptive pill	1.7	2.1	4.0	-1.6	-2.0	-1.5	-1.4	-1.3	-1.5	-1.5	-1.6	-0.6	-1.0	-1.6	-1.4	-1.4
Hand grip strength (left)	1.6	4.1	5.6	2.0	1.9	2.3	2.3	1.6	1.6	1.8	1.9	2.1	2.2	2.1	2.4	2.0
Medication: Levothyroxine sodium	1.6	2.7	4.8	-2.0	-1.9	-2.2	-1.3	-1.4	-0.7	-1.8	-1.7	-1.6	-1.8	-1.6	-1.3	-1.6
Happiness	1.6	2.0	4.1	2.0	0.7	2.0	0.9	0.7	1.2	1.9	2.0	0.9	0.6	1.8	0.8	1.4
Health satisfaction	1.6	2.1	5.0	1.6	0.8	2.2	1.2	1.2	2.1	1.2	2.1	0.3	0.5	1.7	1.2	1.0
Family relationship satisfaction	1.6	1.9	4.9	1.9	1.5	2.2	0.6	1.7	1.1	1.9	1.6	0.0	-0.1	1.5	0.6	1.0
Friendships satisfaction	1.6	2.0	4.2	1.8	0.6	1.9	0.8	1.3	0.8	2.1	1.3	1.6	1.0	1.4	0.8	1.8
Smoking status: Current	1.6	2.5	5.4	1.6	1.4	1.1	1.8	1.6	2.3	1.6	1.7	0.8	1.4	1.7	1.8	1.4
Depression (self-reported)	1.5	1.8	3.4	1.0	0.5	1.0	1.6	1.6	1.4	1.2	1.0	1.6	1.8	1.4	1.5	1.5
Emphysema/chronic bronchitis	1.5	1.7	2.6	1.6	1.2	1.0	1.2	1.3	0.7	1.4	1.5	1.2	1.5	1.4	1.1	1.4
Ever had bowel cancer screening	1.5	1.8	4.2	-0.8	-1.1	-1.0	-1.3	-1.8	-0.5	-1.2	-0.4	-1.8	-2.1	-1.1	-1.2	-1.9
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	2.6	-1.3	-1.4	-1.3	-1.2	-1.2	-1.5	-1.0	-1.6	-0.5	-1.0	-1.4	-1.2	-1.0
Angina	1.4	1.8	4.2	1.4	1.2	1.3	1.1	2.0	0.7	1.8	0.9	1.4	1.4	1.3	1.1	1.5
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	4.8	1.8	0.9	1.9	1.1	1.6	2.1	1.5	2.2	0.4	0.3	1.8	1.1	1.1
Noisy workplace	1.4	1.8	3.8	-1.4	-1.5	-1.0	-1.5	-0.2	-0.7	-1.2	-1.2	-1.4	-1.9	-1.3	-1.4	-1.4
Pulse wave peak to peak time	1.4	1.6	3.4	1.1	0.5	0.5	1.8	-0.0	1.3	1.1	1.2	1.6	1.4	1.2	1.8	1.4
Medication: Lisinopril	1.4	1.8	5.2	1.2	1.7	1.6	1.0	2.3	1.4	1.5	1.0	0.7	0.6	1.3	1.0	1.2
Schizophrenia (2014)	1.3	2.9	5.3	2.1	0.1	1.6	1.8	1.4	1.6	2.3	1.8	1.6	1.1	2.0	1.7	1.9
Relative age voice broke	1.3	1.9	3.4	-1.4	-0.9	-1.0	-1.7	-1.3	-1.9	-1.5	-1.4	-1.2	-0.9	-1.5	-1.6	-1.4
Number of incorrect matches in round	1.3	2.2	4.5	-1.6	-2.1	-1.8	-1.3	-1.1	-1.7	-1.3	-1.9	-0.6	-0.9	-1.6	-1.3	-1.4
Pulse wave Arterial Stiffness index	1.3	1.5	3.2	-1.0	-0.7	-0.5	-1.8	0.1	-1.3	-0.9	-1.2	-1.4	-1.4	-1.2	-1.8	-1.3
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	3.7	-1.7	-1.9	-1.7	-1.4	-1.5	-0.7	-1.7	-1.4	-1.6	-1.9	-1.5	-1.4	-1.7
Eye problems/disorders: None of the above	1.3	1.5	3.6	1.0	1.5	1.2	1.2	1.9	1.1	1.2	1.0	1.1	1.1	1.1	1.2	1.2
Neck or shoulder pain in last month	1.3	1.8	4.2	0.9	1.8	0.9	1.5	2.1	1.3	1.1	0.7	1.1	1.2	1.1	1.5	1.5
Suffer from ‘nerves’	1.3	2.1	4.2	1.6	1.4	0.6	1.2	0.9	0.4	1.8	1.1	2.0	1.9	1.5	1.2	1.8
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.8	-1.4	-1.0	-1.4	-1.0	-1.6	-1.7	-1.3	-1.6	-0.5	-0.4	-1.5	-1.0	-1.4
Pain experienced in last month	1.3	2.2	5.1	-1.2	-2.2	-1.5	-1.7	-1.8	-2.3	-0.9	-1.6	-0.1	-0.8	-1.3	-1.7	-1.0
Bipolar Disorder or Schizophrenia	1.2	2.9	4.2	1.9	0.4	1.9	1.8	1.5	1.4	2.0	1.7	1.9	1.2	1.9	1.8	1.9
Alzheimer’s Disease (in father)	1.2	1.2	3.8	-0.5	-1.9	-0.1	-1.4	-1.6	-0.9	-0.9	-0.3	-1.2	-1.2	-0.7	-1.3	-0.9
Current tobacco smoking	1.2	2.0	4.8	1.4	1.0	0.9	1.6	1.3	2.2	1.4	1.6	0.7	1.1	1.5	1.6	1.2
Multivitamins +/- minerals	1.2	1.5	2.5	-1.1	-1.6	-1.4	-1.1	-1.6	-1.0	-1.1	-1.0	-1.3	-1.2	-1.1	-1.1	-1.3
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	5.9	0.5	1.1	0.4	1.3	1.4	-0.2	1.0	0.1	2.1	2.4	0.9	1.2	1.6
Exposure to tobacco smoke at home	1.2	1.4	2.3	-1.5	-1.3	-1.2	-1.0	-1.3	-1.0	-1.2	-1.4	-0.6	-1.1	-1.2	-1.0	-1.1
Mineral and other dietary supplements	1.2	1.6	6.1	1.6	1.5	1.3	0.4	2.5	0.2	1.8	0.8	1.0	0.6	1.2	0.4	1.3
Asthma (self-reported)	1.2	2.3	5.1	1.0	2.2	1.0	1.6	2.2	1.4	1.0	1.0	1.1	1.8	1.3	1.6	1.6
Worry (Nagel 2018)	1.1	2.4	4.5	1.7	1.0	1.5	1.3	1.5	0.7	2.0	1.2	2.1	1.8	1.6	1.3	1.8
Alzheimer’s Disease (in mother)	1.1	1.3	2.2	-0.9	-0.8	-1.1	-1.4	-0.3	-1.5	-0.5	-1.5	-0.9	-1.3	-1.2	-1.5	-0.9
Reaction Time	1.1	2.0	5.5	0.8	0.6	1.4	2.2	0.7	2.3	0.7	1.4	0.9	1.3	1.3	2.2	1.2
HDL Cholesterol	1.1	1.9	3.5	-0.7	-1.2	-0.4	-1.9	-1.4	-1.4	-0.9	-0.6	-1.8	-1.8	-1.1	-1.8	-1.8
Neuroticism	1.1	2.6	4.4	1.6	1.4	1.6	1.5	2.1	1.1	2.1	1.1	1.9	1.3	1.6	1.5	1.8
Pain all over the body in last month	1.1	1.2	2.8	-1.1	-0.7	-0.4	-1.1	-0.9	-0.4	-1.2	-0.8	-1.7	-1.6	-0.9	-1.1	-1.4
Alcohol intake versus 10 years previously	1.1	1.6	4.9	0.6	2.2	1.1	1.3	1.8	2.1	0.4	1.1	0.1	0.4	0.9	1.4	0.6
Lung cancer (father)	1.1	1.3	2.5	1.3	0.9	1.5	1.2	0.6	1.4	1.0	1.6	1.0	0.6	1.3	1.2	0.7
Illnesses of father: Heart disease	1.1	1.5	3.8	0.7	1.0	1.0	1.1	1.9	0.8	1.2	0.5	1.6	1.6	1.1	1.2	1.4
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.9	-1.1	-0.4	-0.5	-1.7	-0.2	-1.4	-0.9	-1.5	-0.8	-1.0	-1.4	-1.6	-1.0
Supplements: Fish oil (including cod liver oil)	1.1	1.5	4.7	-1.7	-1.8	-0.9	-0.1	-2.2	-0.3	-1.8	-0.9	-0.5	-0.5	-1.1	-0.1	-1.2
Cholesterol lowering medication	1.1	1.6	4.4	0.8	0.7	1.5	1.5	1.3	2.1	0.9	1.2	1.0	0.9	1.3	1.5	1.2
Neuroticism (Nagel 2018)	1.0	2.4	4.4	1.7	0.8	2.0	1.1	2.1	1.3	2.1	1.3	1.7	0.9	1.7	1.1	1.6
High blood pressure (mother)	1.0	1.4	5.6	-0.9	-0.2	-0.4	-0.6	-1.5	0.8	-1.7	0.0	-2.4	-1.5	-0.8	-0.5	-1.6
Father’s age at death	1.0	1.3	3.3	-0.8	-1.4	-0.4	-1.3	-1.2	-1.0	-0.9	-0.6	-1.1	-1.8	-1.0	-1.3	-1.2
Hair/balding pattern: Pattern 4	1.0	2.5	6.7	-1.9	-2.6	-1.1	-1.3	-1.4	-1.0	-1.5	-1.6	-1.1	-1.9	-1.7	-1.2	-1.5
Comparative body size at age 10	1.0	2.8	6.3	2.2	0.9	2.0	1.6	1.3	2.3	1.8	2.5	0.6	0.5	2.0	1.6	1.2
Medication for cholesterol	1.0	1.4	4.4	-0.5	-1.4	-0.9	-1.3	-2.1	-2.1	-0.4	-1.1	-0.2	-0.5	-1.1	-1.3	-0.8
Crohns Disease (2017)	0.9	1.9	3.7	1.1	0.6	0.5	1.7	1.2	1.5	1.7	1.0	1.9	1.3	1.3	1.7	1.7
Lupus	0.9	1.3	3.6	1.8	1.3	1.3	0.8	0.7	1.4	1.2	1.9	0.3	0.0	1.2	0.8	0.8
Respiratory disease	0.9	2.0	3.0	1.2	1.6	1.2	1.6	1.7	1.5	1.0	1.4	1.1	1.3	1.4	1.6	1.6
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.5	1.4	0.2	1.9	1.1	1.4	1.4	1.6	1.3	1.2	0.6	1.5	1.1	1.3
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	2.2	-1.0	-1.5	-1.0	-1.1	-0.9	-0.9	-1.0	-1.0	-0.7	-1.2	-1.1	-1.1	-1.0
Townsend deprivation index at recruitment	0.9	1.2	2.5	0.8	1.2	0.3	1.3	1.4	1.6	1.0	0.9	0.7	0.9	1.0	1.3	1.3
Peak expiratory flow (PEF)	0.9	2.0	3.8	1.0	1.2	1.2	1.6	1.3	0.9	1.4	0.7	1.9	1.7	1.3	1.7	1.7
Average weekly champagne plus white wine intake	0.9	1.3	5.5	1.0	2.4	0.8	1.0	1.2	0.5	0.9	1.0	0.8	1.2	0.9	0.9	1.2
Eye problems/disorders: Glaucoma	0.9	1.0	4.6	-1.0	-1.2	-0.6	-0.4	-2.1	-0.1	-1.3	-0.4	-1.0	-0.6	-0.9	-0.4	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.2	1.5	0.5	1.4	0.8	0.7	0.8	1.4	1.4	0.9	0.5	1.3	0.9	0.7
Systolic Blood Pressure	0.8	4.1	8.1	-2.5	-2.9	-2.2	-1.7	-1.9	-2.4	-1.9	-2.7	-0.3	-0.7	-2.1	-1.7	-1.8
Supplements: Zinc	0.8	0.9	2.6	0.8	1.6	0.6	1.2	0.4	1.2	0.7	0.8	0.4	0.8	1.0	1.1	0.8
Medication: Ramipril	0.8	1.0	1.5	-1.2	-1.2	-0.8	-1.0	-0.1	-0.9	-1.1	-1.1	-0.9	-1.0	-1.2	-0.9	-1.1
Mouth/teeth dental problems: Dentures	0.8	1.4	3.5	-1.6	-1.1	-1.8	-0.4	-0.8	-0.4	-1.9	-1.1	-1.0	-0.5	-1.3	-0.4	-1.5
Asthma	0.8	1.7	4.4	0.8	2.0	0.9	1.3	2.1	1.0	0.8	0.7	0.8	1.5	1.1	1.3	1.4
Glaucoma (self-reported)	0.8	0.9	4.7	-1.0	-0.7	-0.8	-0.4	-2.2	-0.2	-1.4	-0.4	-0.9	-0.4	-0.9	-0.4	-1.0
High blood pressure (siblings)	0.8	1.2	2.2	-1.5	0.2	-1.4	-0.9	-0.1	-0.7	-1.2	-1.5	-1.4	-1.0	-1.2	-0.9	-1.1
Age at first live birth	0.8	1.4	2.8	-0.7	-1.0	-0.8	-1.6	-0.9	-1.7	-0.6	-1.1	-0.9	-1.6	-1.2	-1.6	-1.2
Leg fat mass (right)	0.8	3.1	8.8	1.8	0.5	3.0	1.5	1.9	2.7	1.6	2.2	0.3	0.2	2.0	1.6	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	3.3	-1.6	-1.6	-1.3	-0.7	-1.8	-0.6	-1.6	-1.2	-1.0	-1.3	-1.3	-0.6	-1.3
High cholesterol (Self-reported)	0.8	1.4	2.9	1.2	0.8	1.6	1.0	1.6	1.7	1.4	1.1	0.6	0.4	1.2	1.0	1.0
Ever depressed for a whole week	0.8	1.0	2.0	-1.0	-0.8	-1.2	-0.8	-1.3	-0.3	-1.1	-0.9	-1.4	-0.8	-1.1	-0.8	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	3.1	-0.3	-1.8	-0.5	-1.3	-1.0	-1.5	-0.4	-0.7	-0.7	-0.8	-0.8	-1.3	-1.1
Alzheimer’s Disease (including proxy)	0.7	1.1	2.8	-0.5	-1.7	-0.7	-1.4	-0.8	-1.2	-0.4	-0.9	-1.0	-1.3	-0.7	-1.4	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	4.3	1.3	0.7	1.4	0.3	2.1	0.5	1.5	0.8	0.4	0.4	1.0	0.3	1.1
Hip circumference	0.7	3.1	7.2	2.2	1.0	2.4	1.2	1.8	2.7	1.8	2.6	-0.1	-0.3	2.1	1.3	1.2
Length of working week for main job	0.7	0.7	1.9	0.9	0.6	0.6	0.6	1.1	0.2	1.4	0.3	1.2	0.8	0.7	0.5	1.2
Leg fat percentage (right)	0.7	2.5	8.5	1.3	1.0	2.5	1.4	1.4	2.9	0.8	2.1	-0.5	0.0	1.6	1.5	0.4
Had major operations	0.7	0.8	2.4	0.4	1.1	0.8	1.1	0.8	0.8	0.3	0.6	0.9	1.5	0.7	1.2	0.8
Age at last live birth	0.7	1.0	2.3	-0.2	-0.8	0.1	-1.5	-0.8	-1.3	-0.2	-0.6	-1.1	-1.5	-0.7	-1.5	-1.1
Osteoarthritis (self-reported)	0.7	0.9	3.0	1.1	0.3	1.7	0.6	0.2	1.6	0.6	1.7	-0.3	-0.1	1.1	0.6	0.1
Ever taken oral contraceptive pill	0.7	0.7	4.4	1.0	0.3	2.1	0.2	0.9	0.1	0.9	0.8	0.7	0.5	0.9	0.3	0.5
Alcohol drinker status: Never	0.7	0.9	1.5	1.0	1.1	1.2	0.9	0.9	1.2	0.9	0.9	0.4	0.5	1.0	0.8	0.9
Leg fat percentage (left)	0.7	2.4	7.8	1.2	1.0	2.5	1.4	1.8	2.8	0.8	1.9	-0.4	0.1	1.5	1.4	0.5
Average weekly beer plus cider intake	0.7	1.0	3.3	1.4	0.7	1.3	0.5	0.3	1.5	0.9	1.8	-0.1	-0.1	1.4	0.5	0.6
Fractured/broken bones in last 5 years	0.7	0.9	4.0	0.1	-0.6	0.5	-0.3	-0.8	1.1	-0.6	0.6	-2.0	-1.8	-0.2	-0.3	-1.1
Basal cell carcinoma (self-reported)	0.7	0.8	2.2	1.0	0.5	1.2	1.0	0.3	1.5	0.8	1.4	0.2	-0.2	1.1	1.0	0.5
Leg fat mass (left)	0.7	2.9	8.4	1.7	0.5	2.9	1.4	2.0	2.5	1.4	2.1	0.3	0.2	1.9	1.5	1.0
Irritable Bowel Disease (IBD)	0.6	1.4	3.0	1.0	0.3	0.4	1.6	0.8	1.7	1.3	1.1	1.5	0.7	1.2	1.5	1.2
Fasting Glucose	0.6	0.7	2.2	-0.1	-0.6	-0.8	-1.1	-0.6	-1.5	-0.2	-1.1	-0.7	-0.2	-1.2	-1.0	-0.5
BMI	0.6	3.3	9.3	1.9	1.1	3.0	1.4	2.0	3.0	1.6	2.2	-0.5	-0.5	1.8	1.4	0.9
Sensitivity / hurt feelings	0.6	1.0	2.1	0.7	0.7	1.0	0.9	1.4	0.8	1.1	0.5	1.3	0.8	1.0	0.9	1.4
Qualifications: CSEs or equivalent	0.6	0.8	1.3	0.7	1.1	0.6	0.9	0.9	0.8	0.8	0.7	0.8	0.7	1.0	0.9	1.1
Stomach or abdominal pain in last month	0.6	0.7	2.8	1.1	1.7	0.4	0.4	0.6	0.5	1.1	1.0	0.3	0.8	0.9	0.4	0.7
Supplements: Glucosamine	0.6	0.8	3.1	-0.9	-1.4	-1.0	-0.1	-1.8	0.4	-1.0	-0.3	-0.7	-1.0	-0.6	-0.1	-0.8
Chronic bronchitis/emphysema (father)	0.6	0.7	1.6	-0.8	0.8	-0.5	-1.0	0.8	-0.6	-0.9	-0.8	-1.2	-0.7	-0.9	-1.1	-0.7
Forced vital capacity (FVC)	0.6	2.3	7.4	1.4	0.1	1.0	1.7	0.5	0.6	1.7	1.1	2.7	1.6	1.5	1.8	2.0
Neuroticism score	0.6	1.3	3.1	1.2	1.1	1.4	0.8	1.8	0.6	1.5	0.7	1.1	0.9	1.1	0.8	1.2
Hair/balding pattern: Pattern 3	0.6	0.9	2.6	-0.7	-0.1	-0.8	-0.8	-1.0	-0.2	-1.1	-0.2	-1.6	-1.3	-0.8	-0.8	-1.3
Forced expiratory volume in 1-second (FEV1)	0.6	2.2	5.2	1.3	0.4	1.1	1.9	0.5	1.1	1.5	1.2	2.3	1.5	1.6	1.9	1.7
Blood clot in the leg (DVT)	0.6	0.7	2.8	-0.1	-1.7	-0.1	-1.1	-0.8	-1.4	-0.1	-0.5	-0.4	-0.5	-0.6	-1.1	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.6	1.0	0.3	1.2	0.5	0.3	0.3	1.0	0.9	1.2	1.3	1.1	0.5	0.9
Commuting to job workplace: Public transport	0.6	0.8	1.9	1.0	0.8	0.9	0.3	1.4	-0.1	1.1	0.5	1.0	1.1	0.8	0.3	1.2
Medication: Atorvastatin	0.6	0.7	1.4	0.3	0.3	0.7	1.0	1.2	1.0	0.6	0.4	1.1	0.9	0.7	1.0	1.1
Irritability	0.6	0.9	2.9	1.2	0.3	1.7	0.7	0.9	1.1	1.1	1.3	0.6	0.2	1.1	0.8	0.5
Supplements: Calcium	0.6	0.7	3.6	-0.8	-1.1	-1.1	-0.4	-1.9	-0.6	-0.9	-0.5	-0.2	-0.1	-0.6	-0.4	-0.4
Depression (Nagel 2018)	0.5	0.8	2.6	0.8	-0.3	0.8	-0.4	1.6	-0.5	1.5	-0.1	1.2	0.7	0.5	-0.5	1.2
Intelligence (Savage-Jansen 2018)	0.5	1.4	3.7	1.1	1.3	1.3	1.0	1.9	0.5	1.2	0.9	1.2	1.3	1.1	1.0	1.1
Schizophrenia vs Biploar Disorder	0.5	0.6	1.9	-0.4	-1.4	-1.2	-0.9	-0.5	-1.2	0.0	-0.9	0.3	0.0	-0.5	-0.9	-0.1
Bipolar Disorder (2011)	0.5	0.5	1.8	0.9	0.8	1.4	0.4	1.0	0.4	1.0	0.5	0.4	0.1	0.6	0.4	0.6
Mean Putamen Volume	0.5	0.6	2.2	-1.1	0.1	-1.5	-0.2	-0.6	-0.0	-1.2	-0.9	-0.9	-0.2	-0.8	-0.3	-0.6
HbA1C	0.5	0.5	1.1	0.5	-0.8	-0.3	-1.0	-0.8	-0.8	0.2	-0.7	-0.7	-0.5	-1.0	-1.0	-0.4
Rheumatoid Arthritis	0.5	0.6	2.5	-0.2	-0.7	-0.2	-0.3	-1.6	0.2	-0.7	0.2	-1.1	-1.3	-0.2	-0.4	-1.1
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.1	0.6	0.4	0.6	0.7	-0.1	0.3	0.9	0.4	1.4	1.1	0.6	0.7	1.2
Hearing difficulty/problems: Yes	0.5	0.7	1.5	-0.5	-0.9	-0.2	-1.2	-0.6	-0.9	-0.6	-0.4	-0.8	-1.0	-0.7	-1.2	-1.0
Diabetes (mother)	0.5	0.6	1.2	0.7	0.3	0.7	1.0	0.3	0.6	0.9	0.6	1.1	1.1	0.8	1.0	0.6
Average weekly fortified wine intake	0.5	0.6	2.0	-0.4	-1.3	-0.5	-0.9	-0.6	-1.4	-0.1	-0.9	0.4	-0.2	-0.6	-0.9	-0.5
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.1	-0.7	-0.9	-0.5	-1.0	-0.2	-0.8	-0.9	-0.6	-0.9	-0.5	-0.8	-1.0	-0.9
Sitting height	0.5	3.4	8.4	1.9	-0.6	2.3	1.6	1.2	0.6	2.3	1.4	2.9	1.5	1.9	1.7	2.4
Waist circumference	0.5	1.7	6.0	1.1	0.1	2.3	1.0	1.2	2.4	1.0	1.6	-0.1	-0.4	1.3	1.1	0.6
Had menopause	0.5	0.6	1.3	-1.0	-0.9	-1.1	-0.6	-1.0	-0.4	-1.0	-0.7	-0.6	-0.5	-0.9	-0.6	-0.7
Fluid intelligence score	0.5	1.1	2.1	0.7	1.2	0.9	1.2	1.3	1.1	0.6	0.8	0.9	1.4	0.8	1.2	1.1
Weight	0.5	2.2	7.0	1.5	-0.4	2.6	1.2	1.5	2.0	1.6	1.7	0.7	-0.0	1.7	1.2	1.0
Arm fat percentage (right)	0.5	2.2	6.1	1.4	1.0	2.3	1.0	2.0	2.5	1.3	1.7	-0.1	-0.2	1.6	1.0	0.7
Number of live births	0.5	0.7	2.3	0.6	0.8	1.2	1.0	0.6	1.5	0.5	1.0	0.3	0.5	0.9	1.0	0.5
Prospective memory result	0.5	0.6	1.4	-0.9	-1.1	-1.1	-0.6	-0.3	-0.7	-0.4	-1.2	-0.1	-0.5	-0.8	-0.6	-0.4
Arm fat mass (right)	0.5	2.1	5.9	1.5	0.3	2.4	1.1	1.7	2.3	1.4	1.8	0.3	-0.1	1.6	1.2	0.8
Tense / ‘highly strung’	0.5	0.9	1.7	1.2	0.5	1.3	0.9	0.6	0.9	1.3	0.9	0.8	0.5	1.0	0.9	0.9
Body fat percentage	0.5	1.8	5.3	1.2	0.7	2.3	0.9	1.7	2.3	1.0	1.6	-0.2	-0.2	1.4	1.0	0.5
Medication: Omeprazole	0.5	0.6	1.7	1.2	0.2	1.2	0.6	0.3	0.7	1.0	1.3	0.4	0.2	1.0	0.6	0.2
Whole body fat mass	0.5	2.3	6.4	1.5	0.3	2.5	1.2	1.9	2.2	1.5	1.7	0.4	0.1	1.7	1.3	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.2	1.1	0.8	1.0	0.4	0.2	0.7	0.9	1.1	0.4	0.5	0.9	0.4	0.5
Arm fat percentage (left)	0.5	1.9	5.5	1.3	1.0	2.2	0.8	1.9	2.3	1.2	1.6	-0.3	-0.3	1.4	0.9	0.6
Arm fat mass (left)	0.5	2.1	5.4	1.5	0.3	2.3	1.2	1.7	2.3	1.5	1.7	0.4	0.0	1.7	1.2	0.9
Arm fat-free mass (left)	0.5	2.3	5.2	1.5	-0.9	2.3	1.4	1.1	1.5	1.8	1.5	1.7	0.6	1.6	1.5	1.6
Diastolic blood pressure, automated reading	0.5	1.7	3.5	-1.7	-0.8	-1.2	-0.8	-1.8	-0.9	-1.9	-1.2	-1.3	-0.5	-1.2	-0.8	-1.7
Pack years of smoking	0.5	0.8	1.2	-1.0	-0.6	-0.4	-1.1	-0.8	-0.4	-1.0	-0.8	-1.1	-0.9	-0.9	-1.1	-0.9
Allergy or Eczema	0.4	1.1	2.9	-1.1	-1.4	-1.3	-0.4	-0.0	-1.7	-0.5	-1.6	1.1	1.0	-0.9	-0.4	-0.1
Lung FEV1/FVC ratio	0.4	2.2	5.1	-1.4	-1.1	-0.7	-0.9	-1.8	0.5	-1.9	-0.4	-2.2	-2.2	-1.2	-0.8	-2.2
Chronotype (morning person)	0.4	1.0	2.8	-0.1	1.7	0.3	1.4	0.6	0.7	-0.1	0.3	1.2	1.7	0.4	1.5	0.9
Diabetes (father)	0.4	0.4	1.8	0.6	-0.2	1.4	-0.0	0.0	0.9	0.0	1.1	-0.6	-1.0	0.4	0.1	-0.2
Severe depression (siblings)	0.4	0.5	0.9	0.1	0.8	0.5	0.8	0.9	0.9	0.1	0.4	0.4	0.9	0.6	0.9	0.4
Pack years adult smoking proportion	0.4	0.6	0.9	-0.9	-0.8	-0.4	-0.9	-0.8	-0.4	-0.8	-0.7	-0.8	-0.6	-0.8	-0.9	-0.7
Leg fat-free mass (left)	0.4	2.1	5.3	1.6	-0.6	2.3	1.2	1.3	1.4	1.8	1.6	1.2	0.3	1.7	1.3	1.3
Hand grip strength (right)	0.4	1.2	2.8	0.7	0.9	1.1	1.4	0.7	0.6	0.9	0.6	1.7	1.5	1.0	1.5	1.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.6	1.0	-0.2	0.2	0.5	0.1	0.2	1.2	0.8	1.3	0.4	0.8	0.5	0.8
Body mass index (BMI)	0.4	1.6	5.2	1.1	0.5	2.2	0.9	1.5	2.3	1.0	1.6	-0.3	-0.3	1.3	1.0	0.4
Leg predicted mass (left)	0.4	2.0	5.1	1.6	-0.6	2.2	1.1	1.3	1.3	1.8	1.5	1.2	0.3	1.6	1.2	1.3
Trunk fat mass	0.4	1.8	6.1	1.4	0.1	2.5	0.9	1.7	2.0	1.4	1.5	0.2	-0.3	1.5	0.9	0.8
Qualifications: None of the above	0.4	0.9	3.5	0.4	1.9	0.7	0.5	0.7	1.9	-0.3	1.1	-0.9	-0.0	0.6	0.5	-0.1
Illnesses of siblings	0.4	0.5	1.6	1.3	-0.1	0.9	0.3	-0.7	-0.2	0.9	1.0	0.7	0.5	0.8	0.3	0.5
Pulse rate	0.4	0.6	2.0	-0.2	-0.8	-0.2	-1.3	-0.6	-1.4	-0.1	-0.6	-0.2	-0.9	-0.5	-1.3	-0.6
Wheeze or whistling in the chest in last year	0.4	0.6	2.0	1.1	0.8	1.4	-0.1	1.2	0.3	0.8	0.9	-0.4	0.1	0.9	-0.1	0.5
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.9	0.9	0.9	1.0	0.3	0.6	0.0	0.8	0.6	0.2	0.9	0.7	0.3	0.4
Migraine (self-reported)	0.4	0.5	1.6	-0.2	0.4	0.4	-0.7	-0.2	-0.4	-0.7	0.0	-1.3	-0.8	-0.5	-0.7	-1.1
Overall health rating	0.4	0.8	2.3	0.5	0.8	1.5	0.0	1.0	1.5	0.2	1.1	-1.3	-0.9	0.6	0.1	-0.5
Leg pain on walking	0.4	0.5	1.2	-0.2	-0.7	-0.4	-1.1	0.1	-0.8	-0.4	-0.3	-1.0	-0.9	-0.5	-1.1	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.2	0.7	1.0	0.2	0.2	1.5	-0.1	1.0	0.2	0.6	0.4	0.6	0.2	0.9
Smoking status: Previous	0.4	0.7	1.6	0.6	0.1	1.2	0.8	1.2	0.1	0.8	0.5	1.2	0.9	0.7	0.8	0.7
Whole body fat-free mass	0.4	2.1	4.3	1.5	-0.9	2.1	1.3	1.1	1.3	1.8	1.4	1.8	0.6	1.6	1.4	1.7
Leg fat-free mass (right)	0.4	2.1	4.8	1.5	-0.7	2.2	1.2	1.5	1.3	1.9	1.4	1.6	0.5	1.6	1.3	1.5
Whole body water mass	0.4	2.0	4.2	1.4	-1.0	2.0	1.3	1.1	1.2	1.8	1.3	1.8	0.6	1.5	1.3	1.6
Leg predicted mass (right)	0.4	1.9	4.3	1.4	-0.7	2.1	1.2	1.3	1.3	1.8	1.3	1.5	0.4	1.5	1.3	1.4
Financial situation satisfaction	0.4	0.5	2.6	0.7	0.2	1.6	-0.0	1.0	0.7	0.9	0.6	-0.2	-0.6	0.5	0.0	0.1
Medication: Blood pressure	0.4	0.7	3.0	-0.1	1.0	0.2	1.2	1.2	1.7	-0.1	0.5	0.0	0.6	0.6	1.2	0.2
Basal metabolic rate	0.4	2.4	5.3	1.6	-0.8	2.3	1.4	1.3	1.5	1.9	1.5	1.7	0.6	1.7	1.5	1.7
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.7	0.8	0.2	1.3	0.1	1.2	0.3	0.9	0.6	0.3	0.2	0.7	0.1	0.4
Arm predicted mass (left)	0.4	2.2	4.8	1.5	-0.8	2.2	1.3	1.1	1.4	1.8	1.4	1.7	0.6	1.6	1.4	1.7
Depressed Affect (Nagel 2018)	0.3	0.6	2.0	0.7	0.8	1.0	0.5	1.4	1.0	1.0	0.6	0.3	-0.1	0.8	0.5	0.6
Age at First Birth	0.3	0.4	1.1	-0.9	-1.0	-0.8	0.4	0.3	-0.2	-0.3	-1.0	0.8	0.4	-0.4	0.4	-0.1
Coronary Artery Disease (CAD)	0.3	0.4	1.5	0.5	-0.5	0.4	0.2	0.5	-0.2	0.8	0.1	1.2	0.8	0.3	0.2	1.0
Neuroticism (2016)	0.3	0.4	1.7	0.3	0.6	0.6	0.4	1.3	0.4	0.7	0.1	0.7	0.5	0.4	0.4	1.0
Medication: Metformin	0.3	0.5	1.4	0.4	0.7	0.6	0.5	0.9	0.2	0.6	0.2	1.1	1.2	0.6	0.6	0.7
Trunk fat percentage	0.3	1.2	4.1	1.0	0.5	2.0	0.6	1.6	1.8	1.0	1.2	-0.2	-0.4	1.2	0.6	0.5
Heart attack	0.3	0.4	1.5	0.7	0.1	1.2	0.0	1.0	0.4	0.8	0.5	0.2	0.2	0.6	0.1	0.2
Trunk fat-free mass	0.3	1.7	3.1	1.2	-1.3	1.7	1.2	0.7	1.0	1.5	1.1	1.8	0.6	1.3	1.3	1.5
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.8	-0.5	-0.3	-0.7	-0.5	-0.2	-0.3	-0.5	-0.6	-0.8	-0.9	-0.6	-0.4	-0.7
Medication: Cholesterol lowering	0.3	0.4	2.8	0.4	0.5	0.3	0.1	1.7	0.1	0.9	-0.1	0.6	0.3	0.4	0.1	0.7
Medication: Lansoprazole	0.3	0.3	1.6	0.2	-0.6	0.2	-0.7	-0.7	-0.2	0.3	0.1	-0.7	-1.3	-0.1	-0.8	-0.4
Trunk predicted mass	0.3	1.9	3.7	1.2	-1.3	1.8	1.3	0.8	1.0	1.6	1.1	1.9	0.7	1.3	1.3	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.9	0.6	1.0	0.5	0.3	0.5	0.3	0.7	0.4	0.6	0.8	0.6	0.3	1.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	2.0	-0.7	-0.4	-1.2	-0.2	-1.4	-0.6	-1.0	-0.5	-0.6	-0.2	-0.7	-0.3	-0.6
Gout (self-reported)	0.3	0.5	1.1	1.0	0.3	1.1	-0.2	0.7	0.3	0.9	0.9	-0.2	-0.5	0.9	-0.2	0.4
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.8	0.7	0.9	0.5	0.2	0.9	-0.0	0.7	0.3	0.3	0.7	0.6	0.2	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.9	-0.9	-0.7	-0.7	0.0	-0.3	-0.5	-0.6	-0.7	0.7	0.5	-0.6	-0.0	-0.1
Qualifications: College or University degree	0.3	0.8	4.3	-0.1	-2.1	0.0	-0.8	-1.4	-1.5	-0.1	-0.5	0.3	-0.3	-0.5	-0.8	-0.4
Medication: Allopurinol	0.3	0.5	1.2	1.1	0.3	1.1	0.3	0.7	0.4	0.9	0.9	0.2	0.0	1.0	0.3	0.4
Arm predicted mass (right)	0.3	1.7	3.5	1.2	-1.0	1.9	1.2	0.9	1.0	1.6	1.0	1.6	0.6	1.3	1.3	1.5
Comparative height size at age 10	0.3	1.5	7.8	0.1	-2.8	-1.5	-0.5	-0.9	-1.7	0.9	-0.7	1.7	0.0	-0.2	-0.6	0.8
Average weekly red wine intake	0.3	0.5	3.1	0.1	-1.8	-0.3	0.0	-1.2	-0.6	0.1	0.1	0.8	0.4	0.1	0.0	0.2
Mood swings	0.3	0.6	2.5	0.5	1.2	0.6	0.6	1.6	1.1	0.8	0.5	-0.1	-0.1	0.7	0.6	0.4
Qualifications: nursing, teaching	0.3	0.5	1.1	-0.9	-0.7	-0.9	-0.2	-1.1	-0.1	-0.9	-0.7	-0.4	-0.5	-0.8	-0.2	-1.0
Illnesses of father: None of the above (group 1)	0.3	0.3	1.7	0.2	-0.5	-0.3	-0.5	-1.3	-0.5	-0.1	0.0	-0.5	-0.7	-0.3	-0.5	-0.6
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.8	0.2	-0.6	0.0	0.8	0.3	0.7	0.4	0.3	0.9	0.6	0.5	0.8	0.5
Medication: Bendroflumethiazide	0.3	0.5	3.1	-0.4	-0.5	-0.2	0.9	0.1	1.8	-0.4	0.3	-0.5	-0.7	0.2	0.9	-0.5
Medication: Paracetamol	0.3	0.4	1.4	0.4	0.5	0.3	0.9	0.5	1.2	0.2	0.8	0.3	0.5	0.6	0.9	0.4
Illnesses of father: High blood pressure	0.3	0.4	2.0	-0.5	-1.4	0.1	0.6	-0.6	1.2	-0.4	0.2	-0.2	-0.5	0.0	0.6	-0.5
Unable to work because of sickness or disability	0.3	0.3	1.3	-0.6	-0.2	0.1	-0.5	-0.5	0.6	-0.8	-0.0	-1.1	-0.7	-0.3	-0.4	-0.7
Alcohol drinker status: Previous	0.3	0.3	1.0	-0.7	-0.1	-0.9	-0.3	0.7	-0.2	-0.3	-1.0	-0.4	-0.5	-0.7	-0.3	-0.1
Major Depression (MDD)	0.2	0.3	1.4	0.3	1.0	0.2	0.6	-0.3	0.1	0.2	0.1	0.5	1.2	0.4	0.6	0.5
Breast Cancer	0.2	0.4	1.3	-0.3	-0.3	0.8	-1.1	0.0	-0.2	-0.5	-0.1	-1.1	-0.8	-0.4	-1.0	-0.6
Body Mass Index (BMI) (2010)	0.2	0.2	1.7	0.1	-1.3	0.2	0.3	-0.3	-0.2	0.3	0.1	0.8	0.2	0.2	0.3	0.3
LDL Cholesterol	0.2	0.3	0.9	0.8	-0.5	1.0	-0.5	0.4	-0.8	0.5	0.4	-0.1	-0.4	0.3	-0.5	-0.1
Primary Biliary Cirrhosis	0.2	0.3	1.6	0.4	0.5	0.7	-0.1	1.3	0.3	0.6	0.4	-0.3	-1.1	0.3	-0.2	-0.1
Triglycerides	0.2	0.3	0.9	0.5	0.2	0.0	0.7	-0.0	0.1	0.4	0.3	0.9	0.8	0.3	0.7	0.9
Ulcerative Colitis	0.2	0.4	1.4	0.4	-0.5	0.4	0.6	-1.2	0.5	0.1	0.9	0.8	0.3	0.6	0.6	0.1
Cardiovascular Disease	0.2	0.6	2.9	0.4	1.3	1.2	0.3	1.7	1.0	0.3	0.4	-0.5	-0.0	0.5	0.3	0.3
Lung FVC	0.2	1.1	2.4	0.9	1.0	0.3	1.1	0.6	0.7	1.2	0.8	1.5	1.1	1.0	1.2	1.4
Number of treatments/medications taken	0.2	0.4	1.2	-1.1	-0.7	-0.5	-0.0	0.0	0.6	-1.0	-0.5	-0.6	-0.5	-0.5	0.0	-0.8
Fed-up feelings	0.2	0.4	2.6	-0.6	-0.6	-0.4	-0.2	0.3	0.4	-0.4	-0.5	-0.8	-1.6	-0.5	-0.2	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.6	0.3	-0.5	0.4	-0.6	0.8	-0.6	0.6	-0.2	-0.1	-0.3	0.1	-0.6	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.3	1.3	-0.6	-1.2	-0.1	-0.7	-0.2	-0.6	-0.3	-0.7	0.0	-0.6	-0.7	-0.6	-0.5
High blood pressure	0.2	0.4	1.5	-0.6	0.3	-0.1	-0.7	0.4	0.1	-0.7	-0.2	-1.2	-0.9	-0.5	-0.7	-0.9
Hayfever, allergic rhinitis or eczema	0.2	0.4	2.0	0.0	0.1	0.0	0.5	0.5	-0.4	0.2	-0.1	1.2	1.4	0.3	0.5	0.4
Medication: Atenolol	0.2	0.2	0.8	-0.6	-0.7	-0.2	-0.2	0.3	-0.6	-0.1	-0.7	0.9	0.6	-0.3	-0.2	-0.2
Nervous feelings	0.2	0.4	1.7	0.4	-0.1	0.3	0.1	0.4	-0.5	0.9	-0.1	1.3	0.9	0.3	0.1	0.7
Had other major operations	0.2	0.3	1.4	-0.4	-0.5	-0.4	0.4	-0.8	1.2	-0.5	0.2	-0.6	-0.5	-0.1	0.3	-0.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.2	0.6	1.1	0.4	0.4	0.4	0.5	0.4	0.6	0.0	0.7	0.6	0.4	0.4
Financial difficulties in last 2 years	0.2	0.3	1.0	0.8	0.1	0.9	-0.1	0.3	0.1	1.0	0.5	0.3	0.3	0.7	0.0	0.8
Mouth/teeth dental problems	0.2	0.2	1.1	0.2	-0.4	0.0	-0.5	-1.0	-0.9	0.3	-0.2	0.6	-0.0	-0.1	-0.5	0.1
Pulse wave reflection index	0.2	0.2	0.8	-0.4	0.9	0.0	0.2	0.7	0.7	-0.4	-0.2	-0.6	0.1	-0.2	0.2	-0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.9	-0.2	-1.0	-0.2	-0.6	0.1	-1.0	0.3	-0.8	0.2	-0.7	-0.4	-0.6	-0.1
Medication: Paracetamol	0.2	0.3	0.7	0.3	0.6	0.3	0.8	0.6	0.8	0.2	0.6	0.5	0.7	0.5	0.8	0.4
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.7	-0.2	-0.4	0.0	-0.9	0.6	-0.5	0.2	-0.5	-0.2	-0.8	-0.4	-0.8	-0.0
Forced vital capacity (FVC), Best measure	0.2	0.8	3.5	0.7	-0.6	0.5	1.0	-0.1	0.0	1.1	0.4	1.9	0.6	0.8	1.0	1.2
Arm fat-free mass (right)	0.2	1.0	2.5	0.8	-1.3	1.6	0.9	0.7	0.7	1.2	0.7	1.3	0.4	1.0	1.0	1.2
Shortness of breath walking on level ground	0.2	0.3	1.1	0.4	0.0	0.8	0.4	0.8	1.1	0.5	0.4	-0.1	-0.2	0.4	0.5	0.2
Medication: Ibuprofen	0.2	0.3	1.2	-0.2	0.1	-0.3	-0.5	-0.1	-0.1	-0.4	-0.1	-1.1	-0.9	-0.4	-0.5	-0.8
Mean time to correctly identify matches	0.2	0.4	1.6	-0.6	-0.3	0.2	1.1	-0.6	1.3	-0.7	0.2	-0.1	0.5	-0.0	1.1	-0.1
Heart disease (mother)	0.2	0.2	1.0	-0.4	-0.1	-0.5	0.1	-1.0	0.5	-0.6	-0.1	-0.7	-0.4	-0.2	0.0	-0.5
Pulse rate, automated reading	0.2	0.7	1.7	-0.6	-0.0	-0.9	-1.1	-0.3	-0.7	-0.4	-0.8	-0.9	-1.3	-0.7	-1.2	-0.5
Medication: Aspirin	0.2	0.2	0.7	-0.4	-0.3	-0.2	-0.5	-0.3	-0.2	-0.6	-0.3	-0.9	-0.6	-0.4	-0.4	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.2	0.8	-0.1	0.9	0.2	0.3	-0.3	0.9	0.4	1.1	0.4	0.7	0.1	1.1
Loneliness, isolation	0.2	0.2	0.7	0.0	-0.2	0.3	-0.8	0.1	-0.2	0.0	-0.1	-0.7	-0.8	-0.2	-0.8	-0.3
Diabetes diagnosed by doctor	0.2	0.3	1.0	0.4	0.2	0.9	0.2	0.7	1.0	0.3	0.6	-0.3	-0.5	0.5	0.2	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	0.6	0.3	0.6	-0.3	-0.3	0.1	0.1	0.9	-0.7	-0.6	0.4	-0.3	-0.3
Commuting to job workplace: Walk	0.2	0.2	0.5	0.2	-0.3	-0.6	0.6	-0.5	0.2	0.3	0.2	0.7	0.6	0.2	0.5	0.7
Eye problems/disorders: Cataract	0.2	0.3	1.1	0.1	-0.5	-0.4	-0.3	-1.0	-0.3	-0.4	0.3	-0.7	-0.6	-0.0	-0.3	-0.6
Osteoporosis (self-reported)	0.2	0.3	0.5	0.4	0.5	0.3	0.7	0.3	0.5	0.3	0.5	0.6	0.6	0.6	0.7	0.5
Medication: Aspirin	0.2	0.3	0.5	-0.6	-0.7	-0.2	-0.4	-0.3	-0.1	-0.6	-0.4	-0.7	-0.7	-0.5	-0.3	-0.7
Wears glasses or contact lenses	0.2	0.2	0.8	-0.4	-0.2	-0.8	0.4	-0.4	-0.1	-0.1	-0.3	0.9	0.6	-0.1	0.4	0.2
Schizophrenia (2018)	0.1	0.3	0.9	0.8	-0.8	0.4	0.3	0.4	0.2	0.9	0.5	0.6	0.0	0.6	0.2	0.5
Ulcerative Colitis (UC)	0.1	0.2	0.9	0.4	0.2	0.1	0.6	-0.2	0.9	0.4	0.7	0.3	-0.3	0.5	0.6	0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.9	0.3	0.8	0.4	0.5	1.0	0.1	0.4	0.3	0.7	0.8	0.4	0.5	0.5
Ovarian Cancer	0.1	0.1	0.2	-0.3	0.0	-0.2	-0.2	-0.2	-0.4	-0.2	-0.4	-0.2	-0.4	-0.3	-0.2	-0.3
Blood Platelet Count	0.1	0.8	1.4	0.9	0.8	-0.8	1.1	0.3	0.6	0.9	0.8	1.0	1.2	1.0	1.0	1.0
Blood Red Count	0.1	1.1	2.2	-1.3	0.3	-1.2	-0.7	-1.1	-0.1	-1.5	-1.0	-1.4	-1.1	-1.2	-0.7	-1.2
Blood White Count	0.1	0.5	1.7	0.7	-0.3	0.7	0.8	0.1	1.3	0.6	1.1	0.6	0.5	0.8	0.7	0.7
Height	0.1	1.2	6.7	0.1	-2.6	0.8	0.5	-0.3	-0.9	0.6	-0.3	2.2	0.4	0.3	0.6	0.9
Waist Hip Ratio (WHR)	0.1	0.3	0.7	-0.7	-0.6	0.8	0.7	-0.1	0.7	-0.3	-0.3	0.8	0.3	-0.2	0.7	0.3
Tanning	0.1	0.8	1.7	-1.1	-0.6	-1.3	-0.6	-1.1	-0.8	-1.0	-1.0	-0.6	-0.9	-1.1	-0.5	-0.9
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.4	-0.0	-0.7	0.2	-0.4	0.5	-0.3	0.5	-0.4	0.4	-0.2	-0.0	-0.4	0.5
Relative age of first facial hair	0.1	0.3	1.0	0.3	0.9	1.0	-0.3	0.2	0.3	-0.1	0.5	-0.8	-0.3	0.2	-0.1	-0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	-0.4	-0.2	-0.5	-0.3	0.3	-0.3	-0.1	-0.6	0.2	-0.0	-0.3	-0.3	0.2
Medication for hormone replacement therapy	0.1	0.2	1.1	0.3	0.4	0.3	0.2	1.1	0.2	0.3	0.3	0.1	0.0	0.4	0.1	0.4
Maternal smoking around birth	0.1	0.2	0.5	-0.6	-0.5	-0.7	-0.5	-0.2	-0.1	-0.4	-0.6	-0.3	-0.4	-0.5	-0.5	-0.3
Taking other prescription medications	0.1	0.1	0.4	-0.5	-0.2	-0.2	-0.3	-0.1	0.2	-0.6	-0.3	-0.5	-0.3	-0.4	-0.3	-0.6
Alcohol usually taken with meals	0.1	0.2	1.2	0.0	-0.2	-0.2	-0.1	-0.1	-1.1	0.3	-0.5	0.9	0.4	-0.2	-0.2	0.4
Hearing difficulty/problems with background noise	0.1	0.1	0.9	0.3	0.1	0.9	-0.5	0.1	-0.0	0.0	0.4	-0.4	-0.4	0.0	-0.4	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	1.2	-0.4	-1.1	-0.0	-0.1	0.0	-0.1	-0.1	-0.5	0.5	-0.2	-0.4	-0.1	-0.1
Allergy	0.1	0.3	1.7	-0.2	-0.4	-0.2	-0.6	-0.8	0.1	-0.1	-0.1	-0.7	-1.3	-0.3	-0.7	-0.4
Diabetes (self-reported)	0.1	0.1	0.4	0.1	-0.6	0.4	-0.3	0.3	0.1	0.1	-0.0	-0.2	-0.7	0.0	-0.3	-0.2
Time employed in main current job	0.1	0.2	0.6	-0.3	-0.6	-0.8	-0.3	0.2	-0.5	-0.0	-0.5	0.3	-0.1	-0.3	-0.3	0.1
Falls in the last year	0.1	0.2	1.0	-0.1	-0.6	0.3	-0.0	-0.2	1.0	-0.3	0.5	-0.4	-0.5	0.1	0.0	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.3	0.4	-0.6	0.4	0.9	-0.3	0.4	0.6	0.4	1.1	0.1	0.6	0.9	0.7
Impedance of arm (left)	0.1	0.4	0.9	-0.4	0.3	-0.9	-0.7	-0.5	-0.9	-0.5	-0.6	-0.3	-0.3	-0.6	-0.8	-0.6
Standing height	0.1	1.5	5.6	1.0	-2.3	1.1	0.6	0.1	-0.5	1.4	0.5	2.4	0.5	0.8	0.7	1.4
Medication: Amlodipine	0.1	0.2	0.5	-0.2	0.0	0.3	-0.0	-0.2	0.7	-0.5	0.6	-0.5	-0.6	0.1	-0.0	-0.5
Birth weight	0.1	0.2	0.9	0.5	-0.5	-0.1	0.0	0.3	-0.7	0.9	0.0	0.9	0.1	0.3	-0.0	0.5
Worry too long after embarrassment	0.1	0.2	1.4	0.3	-0.6	0.6	0.1	1.2	-0.1	0.7	-0.3	0.5	0.2	0.2	0.1	0.5
Medication for pain relief, constipation, heartburn	0.1	0.1	0.2	0.5	-0.4	0.1	-0.3	-0.5	-0.3	0.3	0.2	0.1	-0.2	0.1	-0.3	0.2
Medication: Blood pressure	0.1	0.1	0.8	0.1	0.2	0.7	-0.3	0.9	0.1	0.4	-0.0	0.0	-0.2	0.1	-0.2	0.1
Alcohol intake frequency.	0.1	0.2	0.6	-0.3	0.3	-0.0	-0.1	0.8	0.5	-0.1	-0.5	-0.7	-0.7	-0.4	-0.2	-0.1
Number of full sisters	0.1	0.2	0.9	-0.5	0.0	-0.1	0.1	0.9	-0.1	-0.2	-0.7	0.2	0.4	-0.4	0.1	0.2
Hypertension (Self-reported)	0.1	0.2	0.6	-0.4	0.0	0.2	-0.5	0.6	0.1	-0.4	-0.2	-0.8	-0.6	-0.3	-0.5	-0.7
Long-standing illness, disability or infirmity	0.1	0.2	0.7	0.1	0.1	0.4	-0.1	0.7	0.8	0.1	0.4	-0.6	-0.8	0.3	-0.1	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	1.2	0.1	0.4	0.5	0.1	1.1	0.3	0.3	0.1	-0.1	-0.1	0.2	0.2	0.4
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	-0.4	0.4	0.6	-0.0	0.6	0.6	-0.7	0.1	-0.6	0.4	-0.1	0.0	-0.5
Guilty feelings	0.1	0.2	0.8	0.3	-0.4	0.6	-0.5	0.6	-0.1	0.4	0.0	-0.5	-0.9	0.1	-0.5	-0.1
Hearing aid user	0.1	0.1	0.3	-0.5	0.5	-0.1	0.1	0.5	0.2	-0.4	-0.3	-0.2	0.3	-0.2	0.1	-0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.5	0.1	-0.1	-0.4	-0.2	-0.7	-0.2	0.0	0.2	-0.5	-0.4	-0.1	-0.2	-0.5
Number of operations (self-reported)	0.1	0.2	0.7	-0.5	-0.0	-0.1	-0.1	-0.3	0.7	-0.7	0.0	-0.8	-0.6	-0.3	-0.1	-0.5
Vascular/heart problems diagnosed by doctor	0.1	0.3	1.2	0.3	-0.8	-0.3	-0.0	-1.1	-0.7	0.4	-0.0	0.7	0.1	0.0	-0.1	0.5
Heart disease (siblings)	0.1	0.1	0.8	-0.2	0.6	0.0	0.3	0.6	0.9	-0.2	0.1	-0.2	0.0	0.1	0.3	0.1
Impedance of whole body	0.1	0.3	0.9	-0.4	0.3	-0.9	-0.5	-0.5	-0.9	-0.5	-0.6	-0.0	0.0	-0.5	-0.6	-0.3
Blood Eosinophil Count	0.0	0.1	0.2	-0.1	-0.2	0.1	-0.2	-0.5	-0.2	-0.3	-0.1	-0.3	-0.1	-0.2	-0.2	-0.2
Heel T-Score	0.0	0.2	0.4	-0.4	0.2	0.3	0.5	0.5	0.3	-0.2	-0.4	0.6	0.7	-0.1	0.5	0.2
Hair Pigment	0.0	0.8	3.7	1.4	0.4	1.9	-0.6	0.1	0.9	1.0	1.2	-0.1	-0.5	0.7	-0.5	0.6
Vitamin and mineral supplements	0.0	0.1	0.3	-0.0	0.5	0.5	-0.2	0.5	0.1	-0.1	0.0	0.1	-0.1	-0.0	-0.2	-0.1
Impedance of leg (right)	0.0	0.1	0.4	0.1	0.6	-0.2	0.1	-0.5	-0.2	-0.3	0.1	-0.1	0.4	-0.0	0.0	0.1
Tinnitus: Yes, but not now, but have in the past	0.0	0.1	0.4	-0.0	0.6	0.0	-0.1	0.1	-0.0	-0.0	0.0	-0.2	-0.1	-0.0	-0.0	-0.4
Impedance of leg (left)	0.0	0.1	0.6	-0.1	0.8	-0.3	0.2	-0.0	-0.2	-0.2	-0.1	0.4	0.7	-0.0	0.2	0.4
Impedance of arm (right)	0.0	0.1	0.3	0.1	0.5	-0.3	-0.4	-0.1	-0.6	-0.1	-0.1	-0.0	-0.0	-0.2	-0.5	-0.2
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.3	-0.2	-0.5	-0.4	0.3	-0.5	-0.0	-0.1	-0.2	0.4	-0.2	-0.1	0.3	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.1	0.2	0.2	0.3	-0.1	-0.2	-0.1	0.0	-0.1	0.4	-0.4	-0.3	0.1	-0.2	-0.3
Medication: Gliclazide	0.0	0.0	0.3	0.1	-0.1	0.5	0.2	0.1	0.0	0.2	0.1	0.4	0.0	0.1	0.2	-0.2

Hub : Genes

CHMP2B

Models

Trait associations