Hub : Traits :

Father's age at death

13 significantly associated models · 11 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 4 48115264 49091782 1 1 4.0e-07 2.1e-07 0.12 91 OCIAD1
2 12 111154626 112582540 1 1 3.0e-08 1.1e-05 0.28 94 SH2B3
3 15 40085637 41752852 2 1 2.6e-08 1.2e-07 0.26 95 GCHFR
4 15 78032707 79611011 5 1 1.0e-11 7.9e-12 1.00 100 PSMA4
5 15 90730363 92135418 1 1 2.0e-07 5.0e-07 0.46 98 FES

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 1.64 1 0 0.0 0.00 1.00 FES
Irritable Bowel Disease (IBD) 2.14 2 0 0.0 0.00 1.00 FES SH2B3
Major Depression (MDD) 4.01 1 0 0.0 0.00 1.00 FES
Reaction Time 7.07 2 1 3.0 0.00 1.00 FES SH2B3
Breast Cancer 5.27 3 0 0.0 0.00 1.00 FES GCHFR OCIAD1
Ovarian Cancer 1.94 1 0 0.0 0.00 1.00 FES
Prostate Cancer 5.21 1 0 0.0 0.00 1.00 GCHFR
Body Mass Index (BMI) (2010) 2.20 1 0 0.0 0.00 1.00 SH2B3
Coronary Artery Disease (CAD) 5.22 2 0 0.0 0.00 1.00 FES SH2B3
LDL Cholesterol 3.78 1 0 0.0 0.00 1.00 SH2B3
Lupus 3.05 1 0 0.0 0.00 1.00 SH2B3
Primary Biliary Cirrhosis 4.26 1 1 3.0 0.00 1.00 SH2B3
Rheumatoid Arthritis 4.82 2 0 0.0 0.00 1.00 OCIAD1 SH2B3
Schizophrenia 5.63 2 1 3.0 0.00 1.00 FES PSMA4
Blood Eosinophil Count 35.04 1 1 3.0 0.00 1.00 SH2B3
Blood Platelet Count 6.34 2 2 6.1 0.00 1.00 OCIAD1 SH2B3
Blood Red Count 5.66 3 1 3.0 0.00 1.00 FES PSMA4 SH2B3
Blood White Count 17.61 3 2 6.1 0.00 1.00 FES OCIAD1 SH2B3
Height 1.75 3 3 9.1 0.00 1.00 FES OCIAD1 SH2B3
Waist Hip Ratio (WHR) 1.15 2 0 0.0 0.00 1.00 GCHFR SH2B3
Systolic Blood Pressure 23.58 4 3 9.1 0.88 0.12 FES GCHFR OCIAD1 SH2B3
Smoking Status 3.82 2 0 0.0 0.00 1.00 FES GCHFR
Allergy or Eczema 3.78 3 0 0.0 0.00 1.00 FES PSMA4 SH2B3
Cardiovascular Disease 16.55 2 2 6.1 0.00 1.00 FES SH2B3
Hypothyroidism (self reported) 24.12 2 1 3.0 0.00 1.00 GCHFR SH2B3
Respiratory disease 2.52 2 0 0.0 0.00 1.00 FES GCHFR
Type 2 Diabetes (T2D) 3.21 2 0 0.0 0.00 1.00 OCIAD1 SH2B3
Lung FEV1/FVC ratio 1.75 1 1 3.0 0.00 1.00 PSMA4
Lung FVC 2.44 2 1 3.0 0.00 1.00 PSMA4 SH2B3
Neuroticism 1.74 1 0 0.0 0.00 1.00 FES
Hair Pigment 0.59 2 2 6.1 0.00 1.00 FES SH2B3
Tanning 0.35 1 0 0.0 0.00 1.00 SH2B3
Hand grip strength (left) 1.77 1 0 0.0 0.00 1.00 FES
Number of treatments/medications taken 7.04 2 1 3.0 0.00 1.00 FES SH2B3
Sensitivity / hurt feelings 2.72 1 0 0.0 0.00 1.00 FES
Systolic blood pressure, automated reading 18.07 3 3 9.1 0.00 1.00 FES OCIAD1 SH2B3
Angina 9.50 2 1 3.0 0.00 1.00 FES PSMA4
Vitamin and mineral supplements 2.14 1 0 0.0 0.00 1.00 PSMA4
Severe depression (siblings) 2.53 1 0 0.0 0.00 1.00 FES
Pack years adult smoking proportion 44.96 2 1 3.0 0.00 1.00 GCHFR PSMA4
Impedance of leg (right) 1.29 1 1 3.0 0.00 1.00 FES
Leg fat-free mass (left) 1.72 3 0 0.0 0.00 1.00 FES OCIAD1 SH2B3
Trunk fat percentage 1.39 1 0 0.0 0.00 1.00 OCIAD1
Townsend deprivation index at recruitment 1.81 1 0 0.0 0.00 1.00 GCHFR
Maternal smoking around birth 2.35 1 0 0.0 0.00 1.00 PSMA4
Fed-up feelings 3.92 1 1 3.0 0.00 1.00 SH2B3
Frequency of unenthusiasm / disinterest in last 2 weeks 2.73 1 0 0.0 0.00 1.00 SH2B3
Taking other prescription medications 6.71 2 1 3.0 0.00 1.00 GCHFR SH2B3
Age when periods started (menarche) 1.18 1 0 0.0 0.00 1.00 PSMA4
Bilateral oophorectomy (both ovaries removed) 1.87 1 0 0.0 0.00 1.00 PSMA4
High blood pressure 17.38 2 2 6.1 0.00 1.00 FES SH2B3
Hayfever, allergic rhinitis or eczema 3.36 2 0 0.0 0.00 1.00 FES SH2B3
Multivitamins +/- minerals 2.96 1 0 0.0 0.00 1.00 PSMA4
Supplements: Glucosamine 2.48 1 0 0.0 0.00 1.00 GCHFR
Medication: Atenolol 13.37 2 2 6.1 0.00 1.00 FES SH2B3
Medication: Levothyroxine sodium 19.41 1 1 3.0 0.00 1.00 SH2B3
Sitting height 0.69 1 0 0.0 0.00 1.00 FES
Chronic bronchitis/emphysema (father) 9.97 1 1 3.0 0.00 1.00 PSMA4
High blood pressure (mother) 13.30 2 1 3.0 0.00 1.00 FES SH2B3
Body mass index (BMI) 0.72 1 0 0.0 0.00 1.00 OCIAD1
Impedance of leg (left) 1.27 1 1 3.0 0.00 1.00 FES
Leg predicted mass (left) 1.66 3 0 0.0 0.00 1.00 FES OCIAD1 SH2B3
Trunk fat mass 1.73 1 1 3.0 0.00 1.00 OCIAD1
Waist circumference 1.42 1 0 0.0 0.00 1.00 OCIAD1
Number of incorrect matches in round 2.89 1 0 0.0 0.00 1.00 FES
Past tobacco smoking 5.56 3 0 0.0 0.00 1.00 FES GCHFR SH2B3
Alcohol usually taken with meals 2.54 1 0 0.0 0.00 1.00 FES
Forced vital capacity (FVC) 1.50 1 1 3.0 0.00 1.00 PSMA4
Heart attack 7.39 2 1 3.0 0.00 1.00 FES SH2B3
Allergy 3.55 2 0 0.0 0.00 1.00 FES GCHFR
Medication: Ramipril 5.53 2 0 0.0 0.00 1.00 FES SH2B3
Medication: Simvastatin 6.20 1 1 3.0 0.00 1.00 FES
Illnesses of siblings 8.90 3 0 0.0 0.00 1.00 FES GCHFR SH2B3
Weight 2.05 2 1 3.0 0.00 1.00 OCIAD1 SH2B3
Impedance of arm (right) 0.67 1 0 0.0 0.00 1.00 SH2B3
Arm fat percentage (right) 1.14 1 0 0.0 0.00 1.00 OCIAD1
Trunk fat-free mass 2.21 3 1 3.0 0.00 1.00 FES OCIAD1 SH2B3
Hip circumference 1.96 2 0 0.0 0.00 1.00 OCIAD1 SH2B3
Frequency of tiredness / lethargy in last 2 weeks 2.11 1 0 0.0 0.00 1.00 SH2B3
Number of live births 3.64 2 0 0.0 0.00 1.00 FES GCHFR
Forced expiratory volume in 1-second (FEV1) 2.75 1 1 3.0 0.00 1.00 PSMA4
Pulse rate 1.31 1 0 0.0 0.00 1.00 SH2B3
Mouth/teeth dental problems: Dentures 3.80 1 0 0.0 0.00 1.00 PSMA4
Asthma 2.10 1 0 0.0 0.00 1.00 FES
Medication: Cholesterol lowering 6.90 2 1 3.0 0.00 1.00 FES SH2B3
Medication: Lansoprazole 3.04 1 0 0.0 0.00 1.00 SH2B3
Lung cancer (father) 13.91 3 1 3.0 0.00 1.00 FES OCIAD1 PSMA4
Illnesses of mother 9.36 2 1 3.0 0.00 1.00 FES SH2B3
Forced expiratory volume in 1-second (FEV1), Best measure 3.18 1 1 3.0 0.00 1.00 PSMA4
Pulse wave Arterial Stiffness index 3.61 2 0 0.0 0.00 1.00 FES SH2B3
Impedance of arm (left) 0.92 1 0 0.0 0.00 1.00 SH2B3
Arm fat mass (right) 1.40 1 0 0.0 0.00 1.00 OCIAD1
Trunk predicted mass 2.19 3 1 3.0 0.00 1.00 FES OCIAD1 SH2B3
Standing height 1.38 2 2 6.1 0.00 1.00 OCIAD1 SH2B3
Breastfed as a baby 2.57 1 0 0.0 0.00 1.00 FES
Hair/balding pattern: Pattern 4 2.02 1 0 0.0 0.00 1.00 FES
Birth weight of first child 11.95 2 2 6.1 0.00 1.00 FES SH2B3
Peak expiratory flow (PEF) 1.53 1 0 0.0 0.00 1.00 PSMA4
Loud music exposure frequency 4.35 1 0 0.0 0.00 1.00 OCIAD1
Blood clot in the leg (DVT) 3.00 1 0 0.0 0.00 1.00 SH2B3
Medication: Paracetamol 1.94 1 0 0.0 0.00 1.00 OCIAD1
Headache pain in last month 2.65 1 0 0.0 0.00 1.00 FES
Medication for cholesterol, blood pressure or diabetes 13.74 3 2 6.1 0.00 1.00 FES OCIAD1 SH2B3
Gout (self-reported) 3.11 1 0 0.0 0.00 1.00 SH2B3
Hypothyroidism/myxoedema (self-reported) 19.79 1 1 3.0 0.00 1.00 SH2B3
Medication: Amlodipine 5.29 1 1 3.0 0.00 1.00 FES
Birth weight 8.00 2 2 6.1 0.00 1.00 FES SH2B3
Chronic bronchitis/emphysema (mother) 8.44 1 1 3.0 0.00 1.00 PSMA4
High blood pressure (siblings) 9.82 3 1 3.0 0.00 1.00 FES GCHFR SH2B3
Forced vital capacity (FVC), Best measure 1.74 1 1 3.0 0.00 1.00 PSMA4
Body fat percentage 1.10 1 0 0.0 0.00 1.00 OCIAD1
Leg fat percentage (right) 0.69 1 0 0.0 0.00 1.00 OCIAD1
Arm fat-free mass (right) 2.08 2 1 3.0 0.00 1.00 OCIAD1 SH2B3
Exposure to tobacco smoke outside home 3.97 2 0 0.0 0.00 1.00 GCHFR SH2B3
Wheeze or whistling in the chest in last year 3.19 2 0 0.0 0.00 1.00 GCHFR PSMA4
Reason for reducing amount of alcohol drunk: Health precaution 2.60 1 0 0.0 0.00 1.00 GCHFR
Pulse wave peak to peak time 3.93 2 0 0.0 0.00 1.00 FES SH2B3
Qualifications: College or University degree 0.83 1 0 0.0 0.00 1.00 GCHFR
Emphysema/chronic bronchitis 2.44 1 0 0.0 0.00 1.00 PSMA4
Neck or shoulder pain in last month 1.90 1 0 0.0 0.00 1.00 GCHFR
Medication: Blood pressure 15.39 2 2 6.1 0.00 1.00 FES SH2B3
Angina (self-reported) 9.56 2 1 3.0 0.00 1.00 FES PSMA4
Medication: Allopurinol 2.70 1 0 0.0 0.00 1.00 SH2B3
Mean time to correctly identify matches 7.33 2 1 3.0 0.00 1.00 FES SH2B3
Heart disease (mother) 4.55 1 0 0.0 0.00 1.00 FES
Whole body fat mass 1.57 1 0 0.0 0.00 1.00 OCIAD1
Leg fat mass (right) 1.14 1 0 0.0 0.00 1.00 OCIAD1
Arm predicted mass (right) 2.13 2 1 3.0 0.00 1.00 OCIAD1 SH2B3
Alcohol intake frequency. 1.42 1 0 0.0 0.00 1.00 OCIAD1
Comparative height size at age 10 2.89 3 1 3.0 0.00 1.00 FES OCIAD1 SH2B3
Overall health rating 3.17 2 0 0.0 0.00 1.00 GCHFR PSMA4
Chest pain or discomfort 2.35 1 0 0.0 0.00 1.00 GCHFR
Qualifications: NVQ or HND or HNC or equivalent 2.22 1 0 0.0 0.00 1.00 SH2B3
Illness, injury, bereavement, stress in last 2 years 1.79 1 0 0.0 0.00 1.00 GCHFR
Medication: Aspirin 8.32 3 1 3.0 0.00 1.00 FES OCIAD1 SH2B3
Knee pain experienced in last month 2.73 1 0 0.0 0.00 1.00 PSMA4
Hypertension (Self-reported) 17.06 3 2 6.1 0.00 1.00 FES OCIAD1 SH2B3
Illnesses of father: Heart disease 10.16 2 1 3.0 0.00 1.00 FES SH2B3
Smoking status: Previous 6.70 2 0 0.0 0.00 1.00 PSMA4 SH2B3
Whole body fat-free mass 2.01 3 1 3.0 0.00 1.00 FES OCIAD1 SH2B3
Leg fat-free mass (right) 1.70 3 0 0.0 0.00 1.00 FES OCIAD1 SH2B3
Arm fat percentage (left) 1.05 1 0 0.0 0.00 1.00 OCIAD1
Handedness (chirality/laterality): Left-handed 2.57 1 0 0.0 0.00 1.00 FES
Mood swings 2.49 1 0 0.0 0.00 1.00 SH2B3
Loneliness, isolation 3.45 1 0 0.0 0.00 1.00 SH2B3
Long-standing illness, disability or infirmity 3.77 2 0 0.0 0.00 1.00 GCHFR SH2B3
Diabetes diagnosed by doctor 3.06 1 0 0.0 0.00 1.00 SH2B3
Qualifications: nursing, teaching 1.76 1 0 0.0 0.00 1.00 SH2B3
Mouth/teeth dental problems: Mouth ulcers 2.97 1 0 0.0 0.00 1.00 SH2B3
Medication for cholesterol 6.92 2 1 3.0 0.00 1.00 FES SH2B3
Back pain experienced in last month 2.62 1 0 0.0 0.00 1.00 SH2B3
Asthma (self-reported) 2.10 1 0 0.0 0.00 1.00 FES
Medication: Aspirin 7.77 2 1 3.0 0.00 1.00 FES SH2B3
Illnesses of father: None of the above (group 1) 10.94 2 1 3.0 0.00 1.00 FES SH2B3
Smoking status: Current 2.63 1 0 0.0 0.00 1.00 SH2B3
Forced expiratory volume in 1-second (FEV1), predicted percentage 7.13 1 1 3.0 0.00 1.00 PSMA4
Whole body water mass 2.06 3 1 3.0 0.00 1.00 FES OCIAD1 SH2B3
Leg predicted mass (right) 1.71 3 0 0.0 0.00 1.00 FES OCIAD1 SH2B3
Arm fat mass (left) 1.31 1 0 0.0 0.00 1.00 OCIAD1
Number of self-reported non-cancer illnesses 5.69 1 1 3.0 0.00 1.00 SH2B3
Mother's age at death 5.75 2 0 0.0 0.00 1.00 PSMA4 SH2B3
Medication: Blood pressure 14.20 3 2 6.1 0.00 1.00 FES OCIAD1 SH2B3
High cholesterol (Self-reported) 2.85 1 0 0.0 0.00 1.00 FES
Medication: Bendroflumethiazide 7.50 3 1 3.0 0.00 1.00 FES OCIAD1 SH2B3
Medication: Paracetamol 1.88 1 0 0.0 0.00 1.00 OCIAD1
Medication: Lisinopril 4.49 2 0 0.0 0.00 1.00 FES SH2B3
Illnesses of father: High blood pressure 10.54 2 1 3.0 0.00 1.00 FES SH2B3
Ever smoked 7.24 4 0 0.0 0.38 0.62 FES GCHFR PSMA4 SH2B3
Basal metabolic rate 2.04 3 1 3.0 0.00 1.00 FES OCIAD1 SH2B3
Leg fat percentage (left) 0.72 1 0 0.0 0.00 1.00 OCIAD1
Arm fat-free mass (left) 2.47 2 1 3.0 0.00 1.00 OCIAD1 SH2B3
Risk taking 7.96 3 0 0.0 0.00 1.00 FES GCHFR PSMA4
Age started oral contraceptive pill 1.91 1 0 0.0 0.00 1.00 FES
Diastolic blood pressure, automated reading 18.90 3 2 6.1 0.00 1.00 FES OCIAD1 SH2B3
Vascular/heart problems diagnosed by doctor 19.47 4 2 6.1 0.87 0.13 FES GCHFR OCIAD1 SH2B3
Medication: Omeprazole (e.g. Zanprol) 1.88 1 0 0.0 0.00 1.00 SH2B3
Pain experienced in last month 4.66 2 0 0.0 0.00 1.00 PSMA4 SH2B3
Heart attack/myocardial infarction (self-reported) 7.78 2 1 3.0 0.00 1.00 FES SH2B3
Deep venous thrombosis (DVT) (self-reported) 2.86 1 0 0.0 0.00 1.00 SH2B3
Heart disease (siblings) 5.13 2 0 0.0 0.00 1.00 FES SH2B3
Pack years of smoking 41.12 2 1 3.0 0.00 1.00 GCHFR PSMA4
Impedance of whole body 0.74 2 0 0.0 0.00 1.00 FES SH2B3
Leg fat mass (left) 1.19 1 0 0.0 0.00 1.00 OCIAD1
Arm predicted mass (left) 2.31 2 1 3.0 0.00 1.00 OCIAD1 SH2B3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.38
GTEx Adipose Visceral Omentum 0 0.0000 1.46
GTEx Adrenal Gland 0 0.0000 1.37
GTEx Artery Aorta 0 0.0000 1.38
GTEx Artery Coronary 0 0.0000 1.37
GTEx Artery Tibial 0 0.0000 1.41
GTEx Brain Caudate basal ganglia 0 0.0000 1.35
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.34
GTEx Brain Cerebellum 1 0.0505 1.35
GTEx Brain Cortex 0 0.0000 1.35
GTEx Brain Frontal Cortex BA9 0 0.0000 1.51
GTEx Brain Hippocampus 0 0.0000 1.44
GTEx Brain Hypothalamus 0 0.0000 1.45
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.32
GTEx Brain Putamen basal ganglia 0 0.0000 1.33
GTEx Breast Mammary Tissue 0 0.0000 1.38
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.28
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.41
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.33
GTEx Cells Transformed fibroblasts 1 0.0238 1.35
GTEx Colon Sigmoid 0 0.0000 1.37
GTEx Colon Transverse 0 0.0000 1.31
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.39
GTEx Esophagus Mucosa 0 0.0000 1.34
GTEx Esophagus Muscularis 0 0.0000 1.39
GTEx Heart Atrial Appendage 0 0.0000 1.39
GTEx Heart Left Ventricle 0 0.0000 1.35
GTEx Liver 1 0.1395 1.40
GTEx Lung 0 0.0000 1.39
GTEx Muscle Skeletal 0 0.0000 1.35
GTEx Nerve Tibial 0 0.0000 1.39
GTEx Ovary 0 0.0000 1.46
GTEx Pancreas 0 0.0000 1.40
GTEx Pituitary 0 0.0000 1.31
GTEx Prostate 0 0.0000 1.31
GTEx Skin Not Sun Exposed Suprapubic 1 0.0407 1.44
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.38
GTEx Small Intestine Terminal Ileum 0 0.0000 1.40
GTEx Spleen 0 0.0000 1.32
GTEx Stomach 0 0.0000 1.38
GTEx Testis 1 0.0317 1.35
GTEx Thyroid 1 0.0250 1.40
GTEx Uterus 0 0.0000 1.35
GTEx Vagina 0 0.0000 1.35
GTEx Whole Blood 0 0.0000 1.31
METSIM Adipose 0 0.0000 1.31
NTR Blood 0 0.0000 1.37
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.41
YFS Blood 4 0.0866 1.33
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.33
TCGA Breast Tumor 0 0.0000 1.46
TCGA Breast Normal 0 0.0000 1.30
TCGA Ovarian Tumor 0 0.0000 1.31
TCGA Prostate Tumor 2 0.0578 1.30