Hub : Traits :

Diabetes (self-reported)

87 significantly associated models · 35 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 39295972 40699195 1 1 3.4e-07 6.1e-06 2.3e-01 93 RP11-69E11.4
2 1 119761038 120687115 2 1 7.7e-09 5.5e-09 1.0e+00 100 NOTCH2
3 1 213759712 215206914 1 1 2.6e-07 1.3e-07 1.2e-02 77 SMYD2
4 2 26883355 28402863 4 1 4.2e-09 2.2e-10 5.8e-03 81 NRBP1
5 2 42767044 44157441 1 1 3.4e-07 1.4e-07 1.6e-01 93 AC010883.5
6 3 48757291 50833360 5 2 2.4e-09 2.7e-09 8.4e-02 92 RBM6 TCTA
7 4 5575751 7002344 1 1 1.8e-15 1.5e-16 7.8e-04 83 WFS1
8 6 6582123 8009760 1 1 2.8e-11 3.0e-07 2.0e-03 64 SSR1
9 7 6502367 7988091 1 1 4.1e-07 4.5e-06 2.5e-01 94 C1GALT1
10 7 73624615 74494207 1 1 3.5e-08 1.3e-07 1.0e+00 100 PMS2P5
11 8 40811597 42450441 1 2 1.9e-10 7.4e-12 1.7e-01 96 ANK1
12 9 138605924 140004341 1 1 3.7e-07 1.8e-07 1.7e-04 48 SDCCAG3
13 10 80443273 81901722 1 1 4.3e-10 6.2e-12 3.7e-04 73 ZCCHC24
14 10 93657148 95151622 3 1 1.3e-15 5.6e-16 6.7e-02 95 EIF2S2P3
15 10 113511441 115622375 2 1 1.5e-36 2.2e-124 3.7e-95 24 TCF7L2
16 11 16691743 18106069 3 1 8.9e-10 1.4e-10 1.0e+00 100 KCNJ11
17 16 52772129 54210447 1 1 1.7e-07 1.2e-17 3.3e-16 9 RBL2
18 16 69323837 70794031 1 1 1.4e-07 4.6e-09 2.0e-04 60 PDXDC2
19 19 12309739 13750618 3 1 3.7e-08 7.0e-08 2.0e-01 94 CALR

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 4.70 6 3 9.1 -0.98 5.1e-04 AC010883.5 NOTCH2 NRBP1 PMS2P5 SDCCAG3 TCTA
Irritable Bowel Disease (IBD) 4.29 5 2 6.1 -0.98 3.6e-03 AC010883.5 NRBP1 PMS2P5 RBM6 SDCCAG3
Ulcerative Colitis (UC) 2.71 4 1 3.0 -1.00 1.5e-03 AC010883.5 PMS2P5 RBM6 SDCCAG3
Major Depression (MDD) 2.01 1 0 0.0 0.00 1.0e+00 C1GALT1
Reaction Time 1.19 1 0 0.0 0.00 1.0e+00 TCTA
Verbal and Numeric Reasoning (VNR) 3.03 3 2 6.1 0.00 1.0e+00 RBL2 RBM6 TCTA
Breast Cancer 3.34 4 1 3.0 0.70 3.0e-01 CALR NOTCH2 PMS2P5 TCF7L2
Age at First Birth 3.42 2 2 6.1 0.00 1.0e+00 RBM6 TCTA
Body Mass Index (BMI) (2010) 1.96 1 0 0.0 0.00 1.0e+00 RBM6
Coronary Artery Disease (CAD) 2.09 1 0 0.0 0.00 1.0e+00 RBM6
Crohns Disease (2012) 2.93 4 0 0.0 1.00 3.7e-03 AC010883.5 NOTCH2 RBM6 TCTA
Fasting Glucose 5.83 2 1 3.0 0.00 1.0e+00 NRBP1 SMYD2
HDL Cholesterol 2.30 2 1 3.0 0.00 1.0e+00 RBM6 RP11-69E11.4
Schizophrenia 1.05 1 0 0.0 0.00 1.0e+00 KCNJ11
Triglycerides 12.05 2 1 3.0 0.00 1.0e+00 NRBP1 RP11-69E11.4
Type 2 Diabetes (T2D) 11.77 8 2 6.1 -0.97 8.2e-05 AC010883.5 ANK1 EIF2S2P3 KCNJ11 SSR1 TCF7L2 WFS1 ZCCHC24
Ulcerative Colitis 2.38 2 0 0.0 0.00 1.0e+00 AC010883.5 SDCCAG3
Blood Eosinophil Count 1.64 4 4 12.1 0.59 4.1e-01 AC010883.5 EIF2S2P3 RBM6 SDCCAG3
Blood Platelet Count 2.88 6 4 12.1 0.18 7.3e-01 AC010883.5 EIF2S2P3 KCNJ11 NRBP1 RP11-69E11.4 ZCCHC24
Blood Red Count 2.20 5 2 6.1 -0.61 2.8e-01 CALR EIF2S2P3 PDXDC2 SDCCAG3 TCTA
Blood White Count 2.50 5 3 9.1 0.13 8.3e-01 NRBP1 RBM6 RP11-69E11.4 SDCCAG3 ZCCHC24
Heel T-Score 2.29 7 4 12.1 -0.53 2.2e-01 AC010883.5 PMS2P5 RBM6 RP11-69E11.4 SMYD2 SSR1 TCTA
BMI 4.37 8 7 21.2 -0.24 5.6e-01 KCNJ11 PDXDC2 PMS2P5 RBM6 RP11-69E11.4 TCF7L2 TCTA ZCCHC24
Height 1.97 8 8 24.2 0.13 7.5e-01 AC010883.5 CALR KCNJ11 NRBP1 PDXDC2 RBL2 SDCCAG3 SSR1
Waist Hip Ratio (WHR) 3.06 7 5 15.2 -0.87 1.1e-02 AC010883.5 EIF2S2P3 KCNJ11 RBL2 TCF7L2 TCTA ZCCHC24
Systolic Blood Pressure 2.66 7 3 9.1 -0.84 1.9e-02 C1GALT1 KCNJ11 NRBP1 PDXDC2 PMS2P5 TCF7L2 TCTA
Smoking Status 1.12 1 0 0.0 0.00 1.0e+00 KCNJ11
Allergy or Eczema 1.59 2 0 0.0 0.00 1.0e+00 AC010883.5 NRBP1
Cardiovascular Disease 3.87 7 4 12.1 -0.64 1.2e-01 C1GALT1 KCNJ11 NRBP1 PDXDC2 PMS2P5 RP11-69E11.4 TCTA
Hypothyroidism (self reported) 1.19 1 0 0.0 0.00 1.0e+00 AC010883.5
Respiratory disease 1.62 2 0 0.0 0.00 1.0e+00 EIF2S2P3 RBM6
Type 2 Diabetes (T2D) 28.62 20 17 51.5 -0.99 1.5e-17 AC010883.5 ANK1 C1GALT1 CALR EIF2S2P3 KCNJ11 NOTCH2 NRBP1 PDXDC2 PMS2P5 RBL2 RBM6 RP11-69E11.4 SDCCAG3 SMYD2 SSR1 TCF7L2 TCTA WFS1 ZCCHC24
Lung FEV1/FVC ratio 1.68 3 3 9.1 0.00 1.0e+00 AC010883.5 C1GALT1 RP11-69E11.4
Lung FVC 1.38 4 1 3.0 0.59 4.1e-01 C1GALT1 RBM6 SSR1 ZCCHC24
Neuroticism 1.56 1 0 0.0 0.00 1.0e+00 RBM6
Chronotype (morning person) 1.60 1 1 3.0 0.00 1.0e+00 SDCCAG3
Hair Pigment 0.42 6 2 6.1 0.72 1.1e-01 AC010883.5 NRBP1 RP11-69E11.4 SDCCAG3 SSR1 ZCCHC24
Tanning 0.40 2 2 6.1 0.00 1.0e+00 NOTCH2 NRBP1
Hand grip strength (left) 1.44 1 0 0.0 0.00 1.0e+00 PDXDC2
Number of treatments/medications taken 4.24 5 1 3.0 0.58 3.1e-01 C1GALT1 NRBP1 PDXDC2 PMS2P5 RBM6
Relative age of first facial hair 1.66 1 0 0.0 0.00 1.0e+00 PMS2P5
Other serious medical condition/disability diagnosed by doctor 1.25 1 0 0.0 0.00 1.0e+00 PMS2P5
Systolic blood pressure, automated reading 2.15 4 0 0.0 1.00 3.0e-04 KCNJ11 PDXDC2 PMS2P5 TCTA
Eye problems/disorders: Diabetes related eye disease 4.64 1 0 0.0 0.00 1.0e+00 TCF7L2
Medication: Co-codamol 1.46 1 0 0.0 0.00 1.0e+00 RBM6
Medication: Metformin 17.98 16 5 15.2 0.99 2.1e-13 AC010883.5 ANK1 CALR EIF2S2P3 KCNJ11 NRBP1 PDXDC2 PMS2P5 RBL2 RBM6 RP11-69E11.4 SSR1 TCF7L2 TCTA WFS1 ZCCHC24
Diabetes (father) 12.74 7 3 9.1 0.99 5.4e-06 AC010883.5 ANK1 EIF2S2P3 NRBP1 SSR1 TCF7L2 WFS1
Diabetes (mother) 11.02 6 2 6.1 1.00 2.3e-05 AC010883.5 ANK1 CALR EIF2S2P3 TCF7L2 WFS1
Pack years adult smoking proportion 1.66 2 0 0.0 0.00 1.0e+00 PDXDC2 PMS2P5
Impedance of leg (right) 2.81 8 6 18.2 -0.42 3.0e-01 AC010883.5 KCNJ11 NRBP1 PDXDC2 PMS2P5 RBL2 RBM6 RP11-69E11.4
Leg fat-free mass (left) 2.70 7 4 12.1 0.71 7.3e-02 NRBP1 RBL2 RBM6 RP11-69E11.4 SDCCAG3 TCTA WFS1
Trunk fat percentage 2.51 5 2 6.1 0.92 2.8e-02 PDXDC2 PMS2P5 RBM6 TCTA ZCCHC24
Hand grip strength (right) 1.35 1 0 0.0 0.00 1.0e+00 PDXDC2
Maternal smoking around birth 1.74 1 0 0.0 0.00 1.0e+00 RBM6
Fed-up feelings 1.99 2 0 0.0 0.00 1.0e+00 AC010883.5 RBM6
Relative age voice broke 2.32 3 0 0.0 0.00 1.0e+00 PDXDC2 PMS2P5 TCTA
Taking other prescription medications 3.40 2 1 3.0 0.00 1.0e+00 PMS2P5 RBM6
Age when periods started (menarche) 2.57 2 2 6.1 0.00 1.0e+00 PDXDC2 PMS2P5
Heel bone mineral density (BMD) T-score, automated (left) 2.84 4 1 3.0 0.65 3.5e-01 AC010883.5 PMS2P5 RBM6 TCTA
Serious illness, injury or assault to yourself 1.34 1 0 0.0 0.00 1.0e+00 PDXDC2
High blood pressure 3.33 6 2 6.1 0.97 9.8e-04 C1GALT1 KCNJ11 PDXDC2 PMS2P5 RBL2 TCTA
Hayfever, allergic rhinitis or eczema 1.71 2 0 0.0 0.00 1.0e+00 AC010883.5 NRBP1
Sitting height 2.08 7 6 18.2 -0.18 7.1e-01 NRBP1 PDXDC2 RBL2 RP11-69E11.4 SDCCAG3 SSR1 ZCCHC24
Body mass index (BMI) 4.53 7 5 15.2 0.23 6.2e-01 KCNJ11 PDXDC2 PMS2P5 RBM6 RP11-69E11.4 TCF7L2 TCTA
Impedance of leg (left) 3.06 9 5 15.2 -0.25 5.2e-01 AC010883.5 KCNJ11 NOTCH2 NRBP1 PDXDC2 PMS2P5 RBL2 RBM6 RP11-69E11.4
Leg predicted mass (left) 2.68 6 4 12.1 0.69 1.3e-01 NRBP1 RBL2 RBM6 RP11-69E11.4 SDCCAG3 WFS1
Trunk fat mass 2.87 6 3 9.1 0.40 4.3e-01 PDXDC2 PMS2P5 RBM6 RP11-69E11.4 TCF7L2 TCTA
Waist circumference 3.92 7 4 12.1 0.46 3.0e-01 PDXDC2 PMS2P5 RBM6 RP11-69E11.4 TCF7L2 TCTA ZCCHC24
Nervous feelings 1.43 2 0 0.0 0.00 1.0e+00 C1GALT1 PDXDC2
Frequency of tenseness / restlessness in last 2 weeks 1.47 1 0 0.0 0.00 1.0e+00 RBM6
Had menopause 2.15 1 1 3.0 0.00 1.0e+00 NRBP1
Forced vital capacity (FVC) 1.71 6 1 3.0 -0.64 1.7e-01 CALR PDXDC2 RBL2 SMYD2 SSR1 ZCCHC24
Heel bone mineral density (BMD) T-score, automated (right) 2.38 2 1 3.0 0.00 1.0e+00 RBM6 TCTA
Ever unenthusiastic/disinterested for a whole week 1.11 1 0 0.0 0.00 1.0e+00 RBM6
Qualifications: None of the above 2.04 2 1 3.0 0.00 1.0e+00 RBL2 RBM6
Mouth/teeth dental problems 2.01 1 0 0.0 0.00 1.0e+00 PMS2P5
Heart attack 2.21 1 0 0.0 0.00 1.0e+00 AC010883.5
Allergy 1.48 1 0 0.0 0.00 1.0e+00 AC010883.5
Medication: Simvastatin 3.70 4 0 0.0 0.66 3.4e-01 C1GALT1 NRBP1 PDXDC2 TCF7L2
Fluid intelligence score 3.46 4 1 3.0 -0.65 3.5e-01 KCNJ11 RBL2 RBM6 TCTA
Neuroticism score 1.86 3 0 0.0 0.00 1.0e+00 AC010883.5 PDXDC2 RBM6
Weight 3.26 9 3 9.1 0.23 5.6e-01 NRBP1 PDXDC2 PMS2P5 RBL2 RBM6 RP11-69E11.4 SDCCAG3 TCF7L2 TCTA
Impedance of arm (right) 3.00 5 3 9.1 0.05 9.4e-01 KCNJ11 NRBP1 RBM6 TCF7L2 TCTA
Arm fat percentage (right) 3.29 6 2 6.1 0.35 5.0e-01 PDXDC2 PMS2P5 RBM6 RP11-69E11.4 TCF7L2 TCTA
Trunk fat-free mass 2.42 6 4 12.1 0.53 2.8e-01 NRBP1 RBL2 RBM6 RP11-69E11.4 SDCCAG3 SSR1
Hip circumference 3.11 6 3 9.1 -0.14 7.9e-01 PDXDC2 PMS2P5 RBL2 RBM6 RP11-69E11.4 TCF7L2
Alcohol intake versus 10 years previously 3.57 3 1 3.0 0.00 1.0e+00 NRBP1 RBM6 RP11-69E11.4
Worrier / anxious feelings 1.75 3 0 0.0 0.00 1.0e+00 C1GALT1 PDXDC2 TCF7L2
Number of live births 1.68 1 0 0.0 0.00 1.0e+00 RBM6
Forced expiratory volume in 1-second (FEV1) 1.90 5 0 0.0 -0.99 8.8e-04 C1GALT1 CALR PDXDC2 SMYD2 ZCCHC24
Pulse rate 3.33 3 1 3.0 0.00 1.0e+00 NRBP1 RBL2 TCTA
Qualifications: A levels/AS levels or equivalent 2.76 2 1 3.0 0.00 1.0e+00 RBM6 TCTA
Mouth/teeth dental problems: Dentures 2.60 2 1 3.0 0.00 1.0e+00 PMS2P5 RBM6
Asthma 1.48 2 0 0.0 0.00 1.0e+00 EIF2S2P3 RBM6
Medication: Cholesterol lowering 4.34 5 1 3.0 0.62 2.6e-01 C1GALT1 NRBP1 PDXDC2 TCF7L2 TCTA
Prospective memory result 1.56 1 0 0.0 0.00 1.0e+00 RBM6
Illnesses of mother 2.64 1 0 0.0 0.00 1.0e+00 TCTA
Forced expiratory volume in 1-second (FEV1), Best measure 2.06 3 1 3.0 0.00 1.0e+00 C1GALT1 PDXDC2 ZCCHC24
Impedance of arm (left) 2.97 7 3 9.1 -0.16 7.4e-01 AC010883.5 CALR KCNJ11 NRBP1 RBM6 TCF7L2 TCTA
Arm fat mass (right) 3.55 6 4 12.1 0.35 5.0e-01 PDXDC2 PMS2P5 RBM6 RP11-69E11.4 TCF7L2 TCTA
Trunk predicted mass 2.41 6 4 12.1 0.54 2.7e-01 NRBP1 RBL2 RBM6 RP11-69E11.4 SDCCAG3 SSR1
Standing height 2.13 7 6 18.2 -0.12 8.1e-01 CALR KCNJ11 NRBP1 PDXDC2 RBL2 SDCCAG3 SSR1
Exposure to tobacco smoke at home 1.56 1 0 0.0 0.00 1.0e+00 RBM6
Breastfed as a baby 1.80 1 0 0.0 0.00 1.0e+00 TCTA
Hair/balding pattern: Pattern 4 1.84 2 0 0.0 0.00 1.0e+00 AC010883.5 NOTCH2
Birth weight of first child 2.23 2 0 0.0 0.00 1.0e+00 RBL2 SSR1
Peak expiratory flow (PEF) 1.99 2 2 6.1 0.00 1.0e+00 AC010883.5 C1GALT1
Ever highly irritable/argumentative for 2 days 2.20 1 1 3.0 0.00 1.0e+00 RBM6
Qualifications: O levels/GCSEs or equivalent 1.51 1 0 0.0 0.00 1.0e+00 RBM6
Medication: Paracetamol 1.79 1 0 0.0 0.00 1.0e+00 NRBP1
Medication for cholesterol, blood pressure or diabetes 3.81 5 1 3.0 -0.68 2.1e-01 C1GALT1 NRBP1 PDXDC2 RBM6 TCTA
Gout (self-reported) 3.61 1 1 3.0 0.00 1.0e+00 NRBP1
Medication: Ventolin 100micrograms inhaler 1.90 1 0 0.0 0.00 1.0e+00 RBM6
Birth weight 4.78 5 2 6.1 -0.07 9.0e-01 ANK1 EIF2S2P3 SDCCAG3 SMYD2 SSR1
Chronic bronchitis/emphysema (mother) 1.98 1 0 0.0 0.00 1.0e+00 RBM6
Forced vital capacity (FVC), Best measure 1.88 5 2 6.1 -0.51 3.8e-01 PDXDC2 RBM6 SMYD2 SSR1 ZCCHC24
Body fat percentage 3.14 6 3 9.1 0.22 6.8e-01 PDXDC2 PMS2P5 RBM6 TCF7L2 TCTA ZCCHC24
Leg fat percentage (right) 4.02 7 4 12.1 0.36 4.3e-01 PDXDC2 PMS2P5 RBL2 RBM6 TCF7L2 TCTA ZCCHC24
Arm fat-free mass (right) 2.74 6 3 9.1 0.69 1.3e-01 NRBP1 RBL2 RBM6 SDCCAG3 SSR1 TCTA
Exposure to tobacco smoke outside home 1.92 1 0 0.0 0.00 1.0e+00 RBM6
Comparative body size at age 10 1.46 1 0 0.0 0.00 1.0e+00 PDXDC2
Wheeze or whistling in the chest in last year 2.43 1 1 3.0 0.00 1.0e+00 RBM6
Age at first live birth 3.32 2 1 3.0 0.00 1.0e+00 RBM6 TCTA
Qualifications: College or University degree 2.69 2 1 3.0 0.00 1.0e+00 RBL2 RBM6
Medication for pain relief, constipation, heartburn 1.76 1 0 0.0 0.00 1.0e+00 NRBP1
Neck or shoulder pain in last month 1.67 1 0 0.0 0.00 1.0e+00 RP11-69E11.4
Medication: Blood pressure 2.40 2 0 0.0 0.00 1.0e+00 PDXDC2 PMS2P5
Medication: Allopurinol 2.93 1 1 3.0 0.00 1.0e+00 NRBP1
Medication: Seretide 50 evohaler 1.56 1 0 0.0 0.00 1.0e+00 RBM6
Mean time to correctly identify matches 1.30 1 0 0.0 0.00 1.0e+00 TCTA
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.09 1 0 0.0 0.00 1.0e+00 TCF7L2
Whole body fat mass 3.40 6 3 9.1 0.35 5.0e-01 PDXDC2 PMS2P5 RBM6 RP11-69E11.4 TCF7L2 TCTA
Leg fat mass (right) 4.08 6 4 12.1 0.19 7.2e-01 PDXDC2 PMS2P5 RBM6 TCF7L2 TCTA ZCCHC24
Arm predicted mass (right) 2.67 6 2 6.1 0.68 1.4e-01 NRBP1 RBL2 RBM6 SDCCAG3 SSR1 TCTA
Pulse rate, automated reading 5.88 9 6 18.2 0.74 2.3e-02 AC010883.5 EIF2S2P3 NRBP1 PDXDC2 RBL2 RBM6 RP11-69E11.4 TCTA WFS1
Alcohol intake frequency. 5.05 5 4 12.1 0.45 4.5e-01 NRBP1 PDXDC2 PMS2P5 RBM6 TCTA
Comparative height size at age 10 2.27 6 5 15.2 0.02 9.7e-01 AC010883.5 EIF2S2P3 KCNJ11 NRBP1 RBL2 SDCCAG3
Overall health rating 3.73 5 2 6.1 0.67 2.1e-01 C1GALT1 NRBP1 PMS2P5 RBL2 RBM6
Chest pain or discomfort 1.72 1 0 0.0 0.00 1.0e+00 C1GALT1
Age at last live birth 3.88 2 1 3.0 0.00 1.0e+00 EIF2S2P3 RBM6
Leg pain on walking 1.56 1 0 0.0 0.00 1.0e+00 RBM6
Qualifications: NVQ or HND or HNC or equivalent 1.92 1 0 0.0 0.00 1.0e+00 RBM6
Knee pain experienced in last month 1.69 2 0 0.0 0.00 1.0e+00 RBM6 ZCCHC24
Hypertension (Self-reported) 3.41 6 3 9.1 0.97 1.1e-03 C1GALT1 KCNJ11 PDXDC2 PMS2P5 RBL2 TCTA
Illnesses of father: Heart disease 1.77 1 0 0.0 0.00 1.0e+00 ZCCHC24
Illnesses of siblings: Diabetes 6.58 6 1 3.0 1.00 1.7e-05 AC010883.5 EIF2S2P3 PMS2P5 RBM6 TCF7L2 WFS1
Smoking status: Previous 1.44 1 0 0.0 0.00 1.0e+00 CALR
Forced expiratory volume in 1-second (FEV1), predicted 2.03 2 0 0.0 0.00 1.0e+00 KCNJ11 SDCCAG3
Whole body fat-free mass 2.56 8 3 9.1 0.70 5.4e-02 NRBP1 RBL2 RBM6 RP11-69E11.4 SDCCAG3 SSR1 TCTA WFS1
Leg fat-free mass (right) 2.55 6 4 12.1 0.66 1.5e-01 NRBP1 RBL2 RBM6 RP11-69E11.4 SDCCAG3 WFS1
Arm fat percentage (left) 3.43 6 2 6.1 0.34 5.1e-01 PDXDC2 PMS2P5 RBM6 RP11-69E11.4 TCF7L2 TCTA
Average weekly red wine intake 1.47 1 0 0.0 0.00 1.0e+00 RBM6
Mood swings 2.18 2 1 3.0 0.00 1.0e+00 AC010883.5 RBM6
Long-standing illness, disability or infirmity 3.52 3 0 0.0 0.00 1.0e+00 PMS2P5 RBM6 RP11-69E11.4
Diabetes diagnosed by doctor 26.05 20 17 51.5 1.00 1.1e-20 AC010883.5 ANK1 C1GALT1 CALR EIF2S2P3 KCNJ11 NOTCH2 NRBP1 PDXDC2 PMS2P5 RBL2 RBM6 RP11-69E11.4 SDCCAG3 SMYD2 SSR1 TCF7L2 TCTA WFS1 ZCCHC24
Qualifications: nursing, teaching 1.76 2 0 0.0 0.00 1.0e+00 RBM6 TCF7L2
Medication for cholesterol 2.81 3 0 0.0 0.00 1.0e+00 C1GALT1 NRBP1 RBL2
Asthma (self-reported) 1.41 2 0 0.0 0.00 1.0e+00 EIF2S2P3 RBM6
Osteoporosis (self-reported) 1.54 1 0 0.0 0.00 1.0e+00 TCTA
Osteoarthritis (self-reported) 1.64 1 0 0.0 0.00 1.0e+00 RBM6
Medication: Gliclazide 8.83 4 1 3.0 0.99 7.8e-03 EIF2S2P3 KCNJ11 TCF7L2 WFS1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.28 1 0 0.0 0.00 1.0e+00 C1GALT1
Whole body water mass 2.60 8 3 9.1 0.70 5.3e-02 NRBP1 RBL2 RBM6 RP11-69E11.4 SDCCAG3 SSR1 TCTA WFS1
Leg predicted mass (right) 2.52 6 4 12.1 0.67 1.5e-01 NRBP1 RBL2 RBM6 RP11-69E11.4 SDCCAG3 WFS1
Arm fat mass (left) 3.54 6 3 9.1 0.36 4.9e-01 PDXDC2 PMS2P5 RBM6 RP11-69E11.4 TCF7L2 TCTA
Number of self-reported non-cancer illnesses 3.57 5 1 3.0 0.53 3.5e-01 C1GALT1 NRBP1 PDXDC2 PMS2P5 RBM6
Miserableness 2.16 1 1 3.0 0.00 1.0e+00 RBM6
Financial situation satisfaction 2.01 1 0 0.0 0.00 1.0e+00 RBM6
Medication: Blood pressure 3.18 4 1 3.0 0.95 5.0e-02 C1GALT1 KCNJ11 PMS2P5 TCTA
High cholesterol (Self-reported) 4.73 3 1 3.0 0.00 1.0e+00 C1GALT1 NRBP1 PDXDC2
Medication: Bendroflumethiazide 2.03 1 0 0.0 0.00 1.0e+00 C1GALT1
Medication: Atorvastatin 3.10 2 1 3.0 0.00 1.0e+00 NRBP1 TCF7L2
Basal metabolic rate 2.71 9 3 9.1 0.30 4.3e-01 NRBP1 RBL2 RBM6 RP11-69E11.4 SDCCAG3 SSR1 TCF7L2 TCTA WFS1
Leg fat percentage (left) 4.22 7 4 12.1 0.35 4.4e-01 PDXDC2 PMS2P5 RBL2 RBM6 TCF7L2 TCTA ZCCHC24
Arm fat-free mass (left) 2.84 6 3 9.1 0.65 1.6e-01 NRBP1 RBL2 RBM6 SDCCAG3 SSR1 TCTA
Number of operations (self-reported) 1.37 1 0 0.0 0.00 1.0e+00 RBM6
Average weekly beer plus cider intake 1.33 1 0 0.0 0.00 1.0e+00 RBM6
Irritability 1.56 1 0 0.0 0.00 1.0e+00 AC010883.5
Age started oral contraceptive pill 1.79 1 0 0.0 0.00 1.0e+00 RBM6
Diastolic blood pressure, automated reading 2.70 5 3 9.1 0.53 3.6e-01 C1GALT1 PMS2P5 RBM6 TCF7L2 TCTA
Commuting to job workplace: Cycle 1.32 1 0 0.0 0.00 1.0e+00 RBL2
Vascular/heart problems diagnosed by doctor 3.42 6 2 6.1 -0.96 2.1e-03 C1GALT1 KCNJ11 PDXDC2 PMS2P5 RBL2 TCTA
Cholesterol lowering medication 4.13 2 1 3.0 0.00 1.0e+00 NRBP1 TCF7L2
Pain experienced in last month 1.84 2 0 0.0 0.00 1.0e+00 RBM6 RP11-69E11.4
Heart attack/myocardial infarction (self-reported) 2.08 1 0 0.0 0.00 1.0e+00 AC010883.5
Pack years of smoking 1.55 2 0 0.0 0.00 1.0e+00 PDXDC2 PMS2P5
Impedance of whole body 3.02 9 4 12.1 0.07 8.5e-01 AC010883.5 KCNJ11 NOTCH2 NRBP1 PDXDC2 PMS2P5 RBM6 RP11-69E11.4 TCF7L2
Leg fat mass (left) 4.12 6 4 12.1 0.19 7.2e-01 PDXDC2 PMS2P5 RBM6 TCF7L2 TCTA ZCCHC24
Arm predicted mass (left) 2.87 6 2 6.1 0.65 1.6e-01 NRBP1 RBL2 RBM6 SDCCAG3 SSR1 TCTA

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.0573 1.57
GTEx Adipose Visceral Omentum 0 0.0000 1.63
GTEx Adrenal Gland 0 0.0000 1.53
GTEx Artery Aorta 3 0.1008 1.68
GTEx Artery Coronary 1 0.0845 1.48
GTEx Artery Tibial 0 0.0000 1.58
GTEx Brain Caudate basal ganglia 1 0.1087 1.45
GTEx Brain Cerebellar Hemisphere 2 0.1343 1.67
GTEx Brain Cerebellum 2 0.1009 1.67
GTEx Brain Cortex 3 0.2899 1.66
GTEx Brain Frontal Cortex BA9 0 0.0000 1.51
GTEx Brain Hippocampus 0 0.0000 1.49
GTEx Brain Hypothalamus 0 0.0000 1.37
GTEx Brain Nucleus accumbens basal ganglia 1 0.1156 1.55
GTEx Brain Putamen basal ganglia 0 0.0000 1.42
GTEx Breast Mammary Tissue 1 0.0507 1.59
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.57
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.62
GTEx Cells EBV-transformed lymphocytes 1 0.0703 1.59
GTEx Cells Transformed fibroblasts 5 0.1191 1.61
GTEx Colon Sigmoid 0 0.0000 1.55
GTEx Colon Transverse 0 0.0000 1.60
GTEx Esophagus Gastroesophageal Junction 2 0.1384 1.53
GTEx Esophagus Mucosa 5 0.1506 1.60
GTEx Esophagus Muscularis 4 0.1238 1.64
GTEx Heart Atrial Appendage 2 0.1267 1.63
GTEx Heart Left Ventricle 0 0.0000 1.52
GTEx Liver 1 0.1395 1.43
GTEx Lung 3 0.1044 1.62
GTEx Muscle Skeletal 2 0.0692 1.62
GTEx Nerve Tibial 1 0.0231 1.56
GTEx Ovary 2 0.2203 1.77
GTEx Pancreas 2 0.1225 1.58
GTEx Pituitary 1 0.0897 1.64
GTEx Prostate 1 0.1198 1.60
GTEx Skin Not Sun Exposed Suprapubic 2 0.0813 1.64
GTEx Skin Sun Exposed Lower leg 3 0.0824 1.57
GTEx Small Intestine Terminal Ileum 0 0.0000 1.54
GTEx Spleen 1 0.0709 1.55
GTEx Stomach 0 0.0000 1.52
GTEx Testis 5 0.1585 1.58
GTEx Thyroid 6 0.1500 1.70
GTEx Uterus 0 0.0000 1.44
GTEx Vagina 0 0.0000 1.59
GTEx Whole Blood 1 0.0502 1.61
METSIM Adipose 5 0.1085 1.52
NTR Blood 4 0.1665 1.50
ROSMAP Brain Pre-frontal Cortex 2 0.0455 1.51
YFS Blood 1 0.0217 1.54
CommonMind Brain Pre-frontal Cortex 6 0.1116 1.55
TCGA Breast Tumor 1 0.1304 1.47
TCGA Breast Normal 1 0.0238 1.42
TCGA Ovarian Tumor 0 0.0000 1.33
TCGA Prostate Tumor 1 0.0289 1.49