Hub : Traits :

Smoking status: Previous

19 significantly associated models · 15 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 154401972 155762509 2 1 2.9e-07 1.9e-07 2.5e-01 95 EFNA1
2 3 84317575 86808226 1 1 1.4e-08 2.1e-13 1.9e-06 58 CADM2
3 6 110588546 112501537 3 1 9.3e-10 9.4e-11 2.6e-02 88 GTF3C6
4 7 2646223 5003373 1 1 1.3e-08 7.3e-10 8.4e-03 82 SDK1
5 12 111193499 113137832 5 1 2.7e-08 1.7e-10 9.0e-05 62 C12orf47
6 16 69062879 70473934 2 1 4.5e-08 2.1e-07 8.4e-01 100 NOB1
7 18 20393480 21863589 1 1 4.5e-10 3.2e-06 3.3e-01 96 NPC1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 2.39 1 1 3.0 0.00 1.0e+00 EFNA1
Irritable Bowel Disease (IBD) 4.12 2 1 3.0 0.00 1.0e+00 CADM2 EFNA1
Ulcerative Colitis (UC) 4.48 2 0 0.0 0.00 1.0e+00 CADM2 EFNA1
Reaction Time 3.60 1 1 3.0 0.00 1.0e+00 C12orf47
Breast Cancer 2.09 1 0 0.0 0.00 1.0e+00 EFNA1
Bipolar Disorder 2.81 1 0 0.0 0.00 1.0e+00 NPC1
Body Mass Index (BMI) (2010) 3.27 2 0 0.0 0.00 1.0e+00 CADM2 NPC1
Coronary Artery Disease (CAD) 2.66 1 0 0.0 0.00 1.0e+00 C12orf47
Crohns Disease (2012) 2.14 1 0 0.0 0.00 1.0e+00 EFNA1
HbA1C 1.97 1 0 0.0 0.00 1.0e+00 C12orf47
LDL Cholesterol 3.89 1 1 3.0 0.00 1.0e+00 C12orf47
Lupus 1.80 1 0 0.0 0.00 1.0e+00 C12orf47
Primary Biliary Cirrhosis 2.53 1 0 0.0 0.00 1.0e+00 C12orf47
Ulcerative Colitis 2.29 1 0 0.0 0.00 1.0e+00 EFNA1
Blood Eosinophil Count 14.00 2 1 3.0 0.00 1.0e+00 C12orf47 GTF3C6
Blood Platelet Count 1.26 3 2 6.1 0.00 1.0e+00 C12orf47 EFNA1 NOB1
Blood Red Count 5.11 3 3 9.1 0.00 1.0e+00 C12orf47 EFNA1 GTF3C6
Blood White Count 8.29 1 1 3.0 0.00 1.0e+00 C12orf47
Heel T-Score 1.07 2 1 3.0 0.00 1.0e+00 EFNA1 NOB1
BMI 4.79 5 2 6.1 -0.15 8.1e-01 CADM2 EFNA1 GTF3C6 NOB1 NPC1
Height 0.33 2 0 0.0 0.00 1.0e+00 C12orf47 NOB1
Waist Hip Ratio (WHR) 1.09 2 0 0.0 0.00 1.0e+00 C12orf47 SDK1
Systolic Blood Pressure 5.54 4 2 6.1 -0.22 7.8e-01 C12orf47 CADM2 NOB1 SDK1
Smoking Status 11.98 5 4 12.1 -0.97 5.1e-03 CADM2 GTF3C6 NOB1 NPC1 SDK1
Allergy or Eczema 2.21 2 0 0.0 0.00 1.0e+00 C12orf47 EFNA1
Cardiovascular Disease 3.36 2 1 3.0 0.00 1.0e+00 C12orf47 NPC1
Hypothyroidism (self reported) 8.72 1 1 3.0 0.00 1.0e+00 C12orf47
Type 2 Diabetes (T2D) 2.65 1 0 0.0 0.00 1.0e+00 C12orf47
Lung FEV1/FVC ratio 0.87 1 0 0.0 0.00 1.0e+00 CADM2
Lung FVC 1.77 2 1 3.0 0.00 1.0e+00 EFNA1 NOB1
Neuroticism 2.47 1 0 0.0 0.00 1.0e+00 CADM2
Chronotype (morning person) 3.65 2 1 3.0 0.00 1.0e+00 C12orf47 SDK1
Hair Pigment 0.51 2 2 6.1 0.00 1.0e+00 C12orf47 EFNA1
Tanning 1.02 3 1 3.0 0.00 1.0e+00 C12orf47 CADM2 EFNA1
Hand grip strength (left) 2.39 2 0 0.0 0.00 1.0e+00 CADM2 NOB1
Number of treatments/medications taken 2.55 1 0 0.0 0.00 1.0e+00 C12orf47
Relative age of first facial hair 1.54 1 0 0.0 0.00 1.0e+00 NPC1
Systolic blood pressure, automated reading 3.47 1 1 3.0 0.00 1.0e+00 C12orf47
Angina 3.45 1 0 0.0 0.00 1.0e+00 NOB1
Medication for hormone replacement therapy 1.93 1 0 0.0 0.00 1.0e+00 GTF3C6
Impedance of leg (right) 2.88 3 2 6.1 0.00 1.0e+00 CADM2 EFNA1 NOB1
Leg fat-free mass (left) 3.14 4 2 6.1 -0.34 6.6e-01 C12orf47 CADM2 EFNA1 NPC1
Trunk fat percentage 3.04 4 1 3.0 -0.49 5.1e-01 EFNA1 GTF3C6 NOB1 NPC1
Hand grip strength (right) 1.57 1 0 0.0 0.00 1.0e+00 NOB1
Current tobacco smoking 3.44 1 0 0.0 0.00 1.0e+00 GTF3C6
Maternal smoking around birth 4.20 2 0 0.0 0.00 1.0e+00 GTF3C6 SDK1
Fed-up feelings 2.88 1 0 0.0 0.00 1.0e+00 C12orf47
Frequency of unenthusiasm / disinterest in last 2 weeks 1.69 1 0 0.0 0.00 1.0e+00 C12orf47
Taking other prescription medications 3.74 1 0 0.0 0.00 1.0e+00 C12orf47
Age when periods started (menarche) 1.55 1 0 0.0 0.00 1.0e+00 NOB1
Heel bone mineral density (BMD) T-score, automated (left) 1.33 1 0 0.0 0.00 1.0e+00 EFNA1
High blood pressure 3.23 1 1 3.0 0.00 1.0e+00 C12orf47
Hayfever, allergic rhinitis or eczema 2.36 2 0 0.0 0.00 1.0e+00 CADM2 EFNA1
Medication: Atenolol 4.94 2 0 0.0 0.00 1.0e+00 C12orf47 NPC1
Medication: Levothyroxine sodium 9.29 1 1 3.0 0.00 1.0e+00 C12orf47
Body mass index (BMI) 4.00 5 2 6.1 0.21 7.4e-01 CADM2 EFNA1 GTF3C6 NOB1 NPC1
Impedance of leg (left) 3.01 4 2 6.1 -0.10 9.0e-01 CADM2 EFNA1 NOB1 SDK1
Leg predicted mass (left) 3.13 4 2 6.1 -0.34 6.6e-01 C12orf47 CADM2 EFNA1 NPC1
Trunk fat mass 3.50 5 1 3.0 -0.02 9.7e-01 CADM2 EFNA1 GTF3C6 NOB1 NPC1
Waist circumference 3.47 4 2 6.1 0.39 6.1e-01 CADM2 GTF3C6 NOB1 NPC1
Past tobacco smoking 20.72 7 6 18.2 -0.99 7.1e-06 C12orf47 CADM2 EFNA1 GTF3C6 NOB1 NPC1 SDK1
Nervous feelings 5.96 1 1 3.0 0.00 1.0e+00 CADM2
Frequency of tenseness / restlessness in last 2 weeks 2.46 1 0 0.0 0.00 1.0e+00 C12orf47
Hearing difficulty/problems with background noise 1.84 1 0 0.0 0.00 1.0e+00 NPC1
Had other major operations 2.75 1 0 0.0 0.00 1.0e+00 SDK1
Forced vital capacity (FVC) 1.29 1 0 0.0 0.00 1.0e+00 NOB1
Mouth/teeth dental problems 3.43 1 1 3.0 0.00 1.0e+00 EFNA1
Heart attack 4.33 2 0 0.0 0.00 1.0e+00 C12orf47 NOB1
Allergy 1.71 1 0 0.0 0.00 1.0e+00 EFNA1
Diabetes (self-reported) 2.26 1 0 0.0 0.00 1.0e+00 NOB1
Medication: Ramipril 2.33 1 0 0.0 0.00 1.0e+00 C12orf47
Illnesses of siblings 2.66 1 0 0.0 0.00 1.0e+00 C12orf47
Neuroticism score 2.60 1 0 0.0 0.00 1.0e+00 CADM2
Weight 3.64 5 2 6.1 -0.11 8.5e-01 C12orf47 CADM2 EFNA1 GTF3C6 NPC1
Impedance of arm (right) 2.16 1 1 3.0 0.00 1.0e+00 CADM2
Arm fat percentage (right) 3.64 5 1 3.0 0.04 9.5e-01 CADM2 EFNA1 GTF3C6 NOB1 NPC1
Trunk fat-free mass 2.42 3 2 6.1 0.00 1.0e+00 C12orf47 CADM2 NPC1
Hip circumference 2.83 3 1 3.0 0.00 1.0e+00 C12orf47 CADM2 NPC1
Worrier / anxious feelings 4.86 2 1 3.0 0.00 1.0e+00 CADM2 GTF3C6
Frequency of tiredness / lethargy in last 2 weeks 1.89 1 0 0.0 0.00 1.0e+00 C12orf47
Forced expiratory volume in 1-second (FEV1) 1.60 1 0 0.0 0.00 1.0e+00 NOB1
Noisy workplace 2.15 1 0 0.0 0.00 1.0e+00 CADM2
Mouth/teeth dental problems: Dentures 3.45 1 1 3.0 0.00 1.0e+00 EFNA1
Medication: Cholesterol lowering 2.31 1 0 0.0 0.00 1.0e+00 NOB1
Medication: Lansoprazole 3.23 1 0 0.0 0.00 1.0e+00 C12orf47
Forced expiratory volume in 1-second (FEV1), Best measure 1.51 1 0 0.0 0.00 1.0e+00 NOB1
Impedance of arm (left) 2.48 2 1 3.0 0.00 1.0e+00 C12orf47 CADM2
Arm fat mass (right) 4.00 5 2 6.1 0.08 9.0e-01 CADM2 EFNA1 GTF3C6 NOB1 NPC1
Trunk predicted mass 2.40 3 2 6.1 0.00 1.0e+00 C12orf47 CADM2 NPC1
Standing height 0.45 1 0 0.0 0.00 1.0e+00 C12orf47
Tense / 'highly strung' 3.96 1 1 3.0 0.00 1.0e+00 CADM2
Hair/balding pattern: Pattern 4 1.41 1 0 0.0 0.00 1.0e+00 EFNA1
Birth weight of first child 3.11 1 1 3.0 0.00 1.0e+00 C12orf47
Peak expiratory flow (PEF) 1.69 1 0 0.0 0.00 1.0e+00 CADM2
Ever highly irritable/argumentative for 2 days 1.76 1 0 0.0 0.00 1.0e+00 C12orf47
Headache pain in last month 1.83 1 0 0.0 0.00 1.0e+00 C12orf47
Medication for cholesterol, blood pressure or diabetes 2.63 1 0 0.0 0.00 1.0e+00 C12orf47
Gout (self-reported) 3.15 2 0 0.0 0.00 1.0e+00 C12orf47 EFNA1
Hypothyroidism/myxoedema (self-reported) 8.10 1 1 3.0 0.00 1.0e+00 C12orf47
Birth weight 2.31 1 1 3.0 0.00 1.0e+00 C12orf47
High blood pressure (siblings) 2.54 1 0 0.0 0.00 1.0e+00 C12orf47
Forced vital capacity (FVC), Best measure 1.28 1 0 0.0 0.00 1.0e+00 NOB1
Body fat percentage 3.13 4 1 3.0 -0.53 4.7e-01 EFNA1 GTF3C6 NOB1 NPC1
Leg fat percentage (right) 2.53 3 0 0.0 0.00 1.0e+00 CADM2 GTF3C6 NPC1
Arm fat-free mass (right) 3.00 3 1 3.0 0.00 1.0e+00 C12orf47 CADM2 NPC1
Comparative body size at age 10 4.05 2 1 3.0 0.00 1.0e+00 CADM2 NPC1
Worry too long after embarrassment 2.54 1 0 0.0 0.00 1.0e+00 CADM2
Wheeze or whistling in the chest in last year 1.54 1 0 0.0 0.00 1.0e+00 EFNA1
Number of children fathered 3.02 1 0 0.0 0.00 1.0e+00 CADM2
Age at first live birth 1.68 1 0 0.0 0.00 1.0e+00 CADM2
Qualifications: College or University degree 1.75 2 0 0.0 0.00 1.0e+00 NPC1 SDK1
Medication for pain relief, constipation, heartburn 2.40 1 0 0.0 0.00 1.0e+00 GTF3C6
Medication: Blood pressure 3.34 1 1 3.0 0.00 1.0e+00 C12orf47
Angina (self-reported) 3.31 1 0 0.0 0.00 1.0e+00 NOB1
Medication: Allopurinol 3.09 2 0 0.0 0.00 1.0e+00 C12orf47 EFNA1
Mean time to correctly identify matches 3.69 1 1 3.0 0.00 1.0e+00 C12orf47
Heart disease (mother) 2.75 1 0 0.0 0.00 1.0e+00 C12orf47
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.29 1 0 0.0 0.00 1.0e+00 EFNA1
Whole body fat mass 3.79 5 1 3.0 0.05 9.3e-01 CADM2 EFNA1 GTF3C6 NOB1 NPC1
Leg fat mass (right) 3.78 4 2 6.1 0.39 6.1e-01 CADM2 GTF3C6 NOB1 NPC1
Arm predicted mass (right) 2.83 3 1 3.0 0.00 1.0e+00 C12orf47 CADM2 NPC1
Alcohol intake frequency. 5.17 2 2 6.1 0.00 1.0e+00 CADM2 NPC1
Comparative height size at age 10 0.96 2 0 0.0 0.00 1.0e+00 C12orf47 NPC1
Number of full sisters 2.63 1 0 0.0 0.00 1.0e+00 CADM2
Suffer from 'nerves' 5.02 1 1 3.0 0.00 1.0e+00 CADM2
Age at last live birth 2.21 1 0 0.0 0.00 1.0e+00 CADM2
Qualifications: NVQ or HND or HNC or equivalent 3.38 2 0 0.0 0.00 1.0e+00 C12orf47 SDK1
Medication: Aspirin 2.08 1 0 0.0 0.00 1.0e+00 C12orf47
Hypertension (Self-reported) 2.78 1 1 3.0 0.00 1.0e+00 C12orf47
Illnesses of father: Heart disease 2.89 1 0 0.0 0.00 1.0e+00 C12orf47
Forced expiratory volume in 1-second (FEV1), predicted 1.33 1 0 0.0 0.00 1.0e+00 SDK1
Whole body fat-free mass 2.74 3 1 3.0 0.00 1.0e+00 C12orf47 CADM2 NPC1
Leg fat-free mass (right) 2.95 4 1 3.0 -0.34 6.6e-01 C12orf47 CADM2 EFNA1 NPC1
Arm fat percentage (left) 3.67 5 1 3.0 0.03 9.6e-01 CADM2 EFNA1 GTF3C6 NOB1 NPC1
Average weekly red wine intake 7.31 2 1 3.0 0.00 1.0e+00 CADM2 NPC1
Mood swings 2.45 1 0 0.0 0.00 1.0e+00 C12orf47
Loneliness, isolation 2.03 1 0 0.0 0.00 1.0e+00 C12orf47
Long-standing illness, disability or infirmity 3.00 1 0 0.0 0.00 1.0e+00 GTF3C6
Diabetes diagnosed by doctor 2.98 1 0 0.0 0.00 1.0e+00 NOB1
Qualifications: nursing, teaching 1.59 1 0 0.0 0.00 1.0e+00 SDK1
Mouth/teeth dental problems: Mouth ulcers 1.49 1 0 0.0 0.00 1.0e+00 CADM2
Medication for cholesterol 2.49 1 0 0.0 0.00 1.0e+00 C12orf47
Medication: Gliclazide 2.63 1 0 0.0 0.00 1.0e+00 EFNA1
Illnesses of father: None of the above (group 1) 2.34 1 0 0.0 0.00 1.0e+00 C12orf47
Smoking status: Current 3.62 2 0 0.0 0.00 1.0e+00 C12orf47 GTF3C6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.24 1 0 0.0 0.00 1.0e+00 NOB1
Whole body water mass 2.76 3 1 3.0 0.00 1.0e+00 C12orf47 CADM2 NPC1
Leg predicted mass (right) 2.91 4 1 3.0 -0.33 6.7e-01 C12orf47 CADM2 EFNA1 NPC1
Arm fat mass (left) 4.19 5 2 6.1 0.11 8.7e-01 CADM2 EFNA1 GTF3C6 NOB1 NPC1
Number of self-reported non-cancer illnesses 2.90 1 0 0.0 0.00 1.0e+00 C12orf47
Miserableness 1.71 1 0 0.0 0.00 1.0e+00 EFNA1
Wears glasses or contact lenses 2.91 2 0 0.0 0.00 1.0e+00 CADM2 NPC1
Financial situation satisfaction 2.31 1 0 0.0 0.00 1.0e+00 NOB1
Medication: Blood pressure 2.88 1 1 3.0 0.00 1.0e+00 C12orf47
High cholesterol (Self-reported) 1.77 1 0 0.0 0.00 1.0e+00 EFNA1
Medication: Bendroflumethiazide 1.63 1 0 0.0 0.00 1.0e+00 C12orf47
Medication: Atorvastatin 1.98 1 0 0.0 0.00 1.0e+00 EFNA1
Ever smoked 13.63 7 3 9.1 0.98 6.7e-05 C12orf47 CADM2 EFNA1 GTF3C6 NOB1 NPC1 SDK1
Basal metabolic rate 3.03 3 2 6.1 0.00 1.0e+00 C12orf47 CADM2 NPC1
Leg fat percentage (left) 2.58 3 0 0.0 0.00 1.0e+00 CADM2 GTF3C6 NPC1
Arm fat-free mass (left) 3.10 3 1 3.0 0.00 1.0e+00 C12orf47 CADM2 NPC1
Risk taking 8.06 2 1 3.0 0.00 1.0e+00 CADM2 NOB1
Age started oral contraceptive pill 3.78 2 0 0.0 0.00 1.0e+00 NPC1 SDK1
Diastolic blood pressure, automated reading 5.24 3 1 3.0 0.00 1.0e+00 C12orf47 EFNA1 NPC1
Vascular/heart problems diagnosed by doctor 3.43 1 1 3.0 0.00 1.0e+00 C12orf47
Cholesterol lowering medication 1.40 1 0 0.0 0.00 1.0e+00 C12orf47
Pain experienced in last month 2.68 2 0 0.0 0.00 1.0e+00 C12orf47 EFNA1
Heart attack/myocardial infarction (self-reported) 4.24 2 0 0.0 0.00 1.0e+00 C12orf47 NOB1
Impedance of whole body 2.60 1 1 3.0 0.00 1.0e+00 CADM2
Leg fat mass (left) 3.71 4 2 6.1 0.40 6.0e-01 CADM2 GTF3C6 NOB1 NPC1
Arm predicted mass (left) 3.07 3 1 3.0 0.00 1.0e+00 C12orf47 CADM2 NPC1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.51
GTEx Adipose Visceral Omentum 0 0.0000 1.57
GTEx Adrenal Gland 0 0.0000 1.47
GTEx Artery Aorta 0 0.0000 1.51
GTEx Artery Coronary 0 0.0000 1.59
GTEx Artery Tibial 1 0.0266 1.53
GTEx Brain Caudate basal ganglia 0 0.0000 1.54
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.66
GTEx Brain Cerebellum 4 0.2018 1.67
GTEx Brain Cortex 0 0.0000 1.63
GTEx Brain Frontal Cortex BA9 0 0.0000 1.58
GTEx Brain Hippocampus 0 0.0000 1.61
GTEx Brain Hypothalamus 1 0.1695 1.69
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.50
GTEx Brain Putamen basal ganglia 0 0.0000 1.39
GTEx Breast Mammary Tissue 0 0.0000 1.59
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.56
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.49
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.60
GTEx Cells Transformed fibroblasts 1 0.0238 1.52
GTEx Colon Sigmoid 0 0.0000 1.56
GTEx Colon Transverse 1 0.0484 1.59
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.61
GTEx Esophagus Mucosa 0 0.0000 1.50
GTEx Esophagus Muscularis 1 0.0309 1.58
GTEx Heart Atrial Appendage 0 0.0000 1.50
GTEx Heart Left Ventricle 0 0.0000 1.56
GTEx Liver 0 0.0000 1.53
GTEx Lung 0 0.0000 1.59
GTEx Muscle Skeletal 1 0.0346 1.58
GTEx Nerve Tibial 0 0.0000 1.52
GTEx Ovary 0 0.0000 1.57
GTEx Pancreas 0 0.0000 1.66
GTEx Pituitary 0 0.0000 1.61
GTEx Prostate 0 0.0000 1.66
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.61
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.57
GTEx Small Intestine Terminal Ileum 0 0.0000 1.58
GTEx Spleen 0 0.0000 1.61
GTEx Stomach 1 0.0688 1.54
GTEx Testis 0 0.0000 1.58
GTEx Thyroid 0 0.0000 1.54
GTEx Uterus 0 0.0000 1.61
GTEx Vagina 0 0.0000 1.51
GTEx Whole Blood 0 0.0000 1.64
METSIM Adipose 2 0.0434 1.46
NTR Blood 0 0.0000 1.46
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.47
YFS Blood 0 0.0000 1.49
CommonMind Brain Pre-frontal Cortex 1 0.0186 1.49
TCGA Breast Tumor 0 0.0000 1.66
TCGA Breast Normal 2 0.0475 1.43
TCGA Ovarian Tumor 1 0.0342 1.37
TCGA Prostate Tumor 0 0.0000 1.41