Hub : Traits :

Hearing difficulty/problems with background noise

59 significantly associated models · 26 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 204927136 206329620 4 1 3.4e-09 8.7e-09 1.0e+00 100 RAB7L1
2 5 72148496 73934274 4 2 7.9e-10 5.3e-13 4.3e-07 51 ANKRA2 ARHGEF28
3 6 42611872 44034691 1 1 1.4e-14 1.5e-14 1.0e+00 100 ZNF318
4 10 75064567 76568774 1 1 3.7e-07 1.6e-06 6.2e-01 99 VCL
5 10 103527782 105201577 6 1 1.5e-08 3.3e-07 1.6e-01 92 LOC100505761
6 14 103161201 104866687 3 1 2.5e-08 5.6e-07 4.8e-01 98 MARK3
7 15 74431715 75825337 1 1 2.3e-07 2.5e-07 4.4e-02 85 ULK3
8 17 42884538 43913030 3 1 8.1e-08 4.5e-06 8.7e-01 100 LRRC37A4P
9 19 58177308 59095126 1 1 1.8e-07 6.5e-05 3.2e-01 94 NCRNA00181

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Irritable Bowel Disease (IBD) 1.91 1 0 0.0 0.00 1.0000 RAB7L1
Ulcerative Colitis (UC) 1.62 1 0 0.0 0.00 1.0000 RAB7L1
Reaction Time 2.15 2 0 0.0 0.00 1.0000 RAB7L1 VCL
Verbal and Numeric Reasoning (VNR) 1.31 1 0 0.0 0.00 1.0000 LRRC37A4P
Breast Cancer 3.14 2 2 6.1 0.00 1.0000 LRRC37A4P ULK3
Ovarian Cancer 3.77 1 1 3.0 0.00 1.0000 LRRC37A4P
Prostate Cancer 3.63 1 0 0.0 0.00 1.0000 RAB7L1
LDL Cholesterol 1.47 1 0 0.0 0.00 1.0000 ULK3
Neuroticism 3.20 1 1 3.0 0.00 1.0000 LRRC37A4P
Primary Biliary Cirrhosis 1.61 1 0 0.0 0.00 1.0000 LRRC37A4P
Schizophrenia 2.89 1 1 3.0 0.00 1.0000 MARK3
Blood Eosinophil Count 2.03 3 1 3.0 0.00 1.0000 LRRC37A4P MARK3 VCL
Blood Platelet Count 1.40 3 2 6.1 0.00 1.0000 ULK3 VCL ZNF318
Blood Red Count 5.07 4 2 6.1 -0.33 0.6653 LOC100505761 LRRC37A4P MARK3 ULK3
Blood White Count 1.32 3 0 0.0 0.00 1.0000 LOC100505761 LRRC37A4P MARK3
Heel T-Score 4.83 4 3 9.1 0.27 0.7319 ARHGEF28 LRRC37A4P MARK3 ZNF318
BMI 2.67 6 1 3.0 0.37 0.4681 LOC100505761 MARK3 RAB7L1 ULK3 VCL ZNF318
Height 2.16 5 5 15.2 -0.48 0.4183 LOC100505761 LRRC37A4P MARK3 RAB7L1 ZNF318
Waist Hip Ratio (WHR) 3.13 2 2 6.1 0.00 1.0000 LRRC37A4P ZNF318
Systolic Blood Pressure 6.69 4 4 12.1 0.93 0.0737 LRRC37A4P ULK3 VCL ZNF318
Smoking Status 2.86 3 0 0.0 0.00 1.0000 LOC100505761 LRRC37A4P MARK3
Allergy or Eczema 1.46 1 0 0.0 0.00 1.0000 ULK3
Cardiovascular Disease 5.98 4 2 6.1 0.64 0.3579 MARK3 ULK3 VCL ZNF318
Lung FEV1/FVC ratio 1.95 1 1 3.0 0.00 1.0000 RAB7L1
Lung FVC 4.79 2 2 6.1 0.00 1.0000 LRRC37A4P RAB7L1
Neuroticism 4.34 1 1 3.0 0.00 1.0000 LRRC37A4P
Chronotype (morning person) 1.10 1 0 0.0 0.00 1.0000 ZNF318
Hair Pigment 0.45 3 2 6.1 0.00 1.0000 ARHGEF28 MARK3 RAB7L1
Tanning 0.29 1 0 0.0 0.00 1.0000 ULK3
Hand grip strength (left) 3.38 2 2 6.1 0.00 1.0000 LRRC37A4P RAB7L1
Number of treatments/medications taken 2.12 1 0 0.0 0.00 1.0000 RAB7L1
Sensitivity / hurt feelings 4.39 1 1 3.0 0.00 1.0000 LRRC37A4P
Hearing difficulty/problems: Yes 16.05 7 3 9.1 0.94 0.0017 ANKRA2 ARHGEF28 LOC100505761 LRRC37A4P ULK3 VCL ZNF318
Relative age of first facial hair 6.19 1 1 3.0 0.00 1.0000 LRRC37A4P
Other serious medical condition/disability diagnosed by doctor 2.82 1 0 0.0 0.00 1.0000 RAB7L1
Systolic blood pressure, automated reading 4.58 4 3 9.1 -0.92 0.0800 LRRC37A4P ULK3 VCL ZNF318
Angina 1.49 1 0 0.0 0.00 1.0000 MARK3
Pack years adult smoking proportion 2.54 1 0 0.0 0.00 1.0000 MARK3
Impedance of leg (right) 2.55 5 1 3.0 0.62 0.2617 LOC100505761 LRRC37A4P MARK3 RAB7L1 ZNF318
Leg fat-free mass (left) 1.82 2 1 3.0 0.00 1.0000 RAB7L1 VCL
Trunk fat percentage 1.62 3 0 0.0 0.00 1.0000 LRRC37A4P MARK3 NCRNA00181
Hand grip strength (right) 3.12 2 1 3.0 0.00 1.0000 LRRC37A4P RAB7L1
Maternal smoking around birth 2.03 1 0 0.0 0.00 1.0000 MARK3
Fed-up feelings 2.02 1 0 0.0 0.00 1.0000 LRRC37A4P
Relative age voice broke 3.81 1 1 3.0 0.00 1.0000 LRRC37A4P
Taking other prescription medications 2.13 1 0 0.0 0.00 1.0000 ZNF318
Age when periods started (menarche) 2.17 2 0 0.0 0.00 1.0000 LRRC37A4P RAB7L1
Heel bone mineral density (BMD) T-score, automated (left) 2.77 2 1 3.0 0.00 1.0000 LRRC37A4P MARK3
High blood pressure 6.29 5 2 6.1 -0.59 0.2959 LOC100505761 LRRC37A4P ULK3 VCL ZNF318
Hayfever, allergic rhinitis or eczema 1.40 1 0 0.0 0.00 1.0000 ULK3
Multivitamins +/- minerals 2.51 1 0 0.0 0.00 1.0000 RAB7L1
Supplements: Glucosamine 3.02 1 0 0.0 0.00 1.0000 ULK3
Sitting height 3.21 4 2 6.1 0.30 0.6983 LOC100505761 LRRC37A4P RAB7L1 ZNF318
High blood pressure (mother) 2.92 1 0 0.0 0.00 1.0000 ZNF318
Body mass index (BMI) 2.00 1 1 3.0 0.00 1.0000 MARK3
Impedance of leg (left) 2.45 6 1 3.0 0.34 0.5133 LOC100505761 LRRC37A4P MARK3 RAB7L1 VCL ZNF318
Leg predicted mass (left) 1.80 2 1 3.0 0.00 1.0000 RAB7L1 VCL
Trunk fat mass 1.50 3 0 0.0 0.00 1.0000 LRRC37A4P MARK3 NCRNA00181
Waist circumference 1.84 2 0 0.0 0.00 1.0000 MARK3 ULK3
Number of incorrect matches in round 2.28 1 0 0.0 0.00 1.0000 RAB7L1
Past tobacco smoking 2.36 1 0 0.0 0.00 1.0000 LOC100505761
Nervous feelings 2.61 1 1 3.0 0.00 1.0000 LRRC37A4P
Frequency of tenseness / restlessness in last 2 weeks 2.91 1 1 3.0 0.00 1.0000 LRRC37A4P
Hair/balding pattern: Pattern 2 2.68 1 0 0.0 0.00 1.0000 LRRC37A4P
Forced vital capacity (FVC) 3.45 2 1 3.0 0.00 1.0000 ANKRA2 LRRC37A4P
Heel bone mineral density (BMD) T-score, automated (right) 2.23 2 0 0.0 0.00 1.0000 LRRC37A4P MARK3
Financial difficulties in last 2 years 2.71 1 0 0.0 0.00 1.0000 MARK3
Mouth/teeth dental problems 3.78 2 1 3.0 0.00 1.0000 LRRC37A4P MARK3
Allergy 1.53 1 0 0.0 0.00 1.0000 ULK3
Medication: Ramipril 2.49 1 0 0.0 0.00 1.0000 ULK3
Fluid intelligence score 1.47 1 0 0.0 0.00 1.0000 LRRC37A4P
Neuroticism score 4.58 2 1 3.0 0.00 1.0000 LRRC37A4P RAB7L1
Weight 1.51 2 1 3.0 0.00 1.0000 RAB7L1 ULK3
Impedance of arm (right) 2.28 3 1 3.0 0.00 1.0000 LRRC37A4P RAB7L1 VCL
Arm fat percentage (right) 1.79 2 1 3.0 0.00 1.0000 MARK3 NCRNA00181
Trunk fat-free mass 1.72 1 1 3.0 0.00 1.0000 RAB7L1
Hip circumference 1.42 2 0 0.0 0.00 1.0000 MARK3 RAB7L1
Father's age at death 2.35 1 0 0.0 0.00 1.0000 ULK3
Worrier / anxious feelings 2.38 1 0 0.0 0.00 1.0000 LRRC37A4P
Frequency of tiredness / lethargy in last 2 weeks 1.96 1 0 0.0 0.00 1.0000 MARK3
Hair/balding pattern: Pattern 3 5.50 2 1 3.0 0.00 1.0000 LRRC37A4P ULK3
Number of live births 1.86 1 0 0.0 0.00 1.0000 LRRC37A4P
Forced expiratory volume in 1-second (FEV1) 3.70 1 1 3.0 0.00 1.0000 LRRC37A4P
Medication: Ibuprofen (e.g. Nurofen) 3.65 2 0 0.0 0.00 1.0000 LRRC37A4P ULK3
Lung cancer (father) 2.56 1 0 0.0 0.00 1.0000 MARK3
Forced expiratory volume in 1-second (FEV1), Best measure 3.35 1 1 3.0 0.00 1.0000 LRRC37A4P
Impedance of arm (left) 2.39 3 1 3.0 0.00 1.0000 LRRC37A4P RAB7L1 VCL
Arm fat mass (right) 1.71 3 1 3.0 0.00 1.0000 MARK3 NCRNA00181 RAB7L1
Trunk predicted mass 1.74 1 1 3.0 0.00 1.0000 RAB7L1
Standing height 2.18 5 4 12.1 0.47 0.4293 LOC100505761 LRRC37A4P MARK3 RAB7L1 ZNF318
Breastfed as a baby 1.53 1 0 0.0 0.00 1.0000 RAB7L1
Tense / 'highly strung' 2.06 1 0 0.0 0.00 1.0000 RAB7L1
Hair/balding pattern: Pattern 4 8.42 1 1 3.0 0.00 1.0000 LRRC37A4P
Birth weight of first child 2.05 1 0 0.0 0.00 1.0000 ULK3
Peak expiratory flow (PEF) 4.06 3 2 6.1 0.00 1.0000 LRRC37A4P RAB7L1 ULK3
Qualifications: O levels/GCSEs or equivalent 2.36 1 0 0.0 0.00 1.0000 ULK3
Medication: Paracetamol 3.88 2 1 3.0 0.00 1.0000 LRRC37A4P MARK3
Headache pain in last month 3.36 1 1 3.0 0.00 1.0000 LRRC37A4P
Medication for cholesterol, blood pressure or diabetes 1.77 1 0 0.0 0.00 1.0000 ULK3
Medication: Amlodipine 3.80 1 0 0.0 0.00 1.0000 ZNF318
Birth weight 1.68 1 0 0.0 0.00 1.0000 RAB7L1
Forced vital capacity (FVC), Best measure 3.31 2 1 3.0 0.00 1.0000 ANKRA2 LRRC37A4P
Body fat percentage 1.42 2 0 0.0 0.00 1.0000 MARK3 NCRNA00181
Leg fat percentage (right) 0.97 1 0 0.0 0.00 1.0000 MARK3
Arm fat-free mass (right) 1.77 2 1 3.0 0.00 1.0000 RAB7L1 VCL
Comparative body size at age 10 2.24 2 0 0.0 0.00 1.0000 RAB7L1 ZNF318
Number of full brothers 2.12 1 0 0.0 0.00 1.0000 LRRC37A4P
Worry too long after embarrassment 1.90 1 0 0.0 0.00 1.0000 LRRC37A4P
Seen a psychiatrist for nerves, anxiety, tension or depression 2.41 1 0 0.0 0.00 1.0000 RAB7L1
Wheeze or whistling in the chest in last year 2.62 2 0 0.0 0.00 1.0000 MARK3 ZNF318
Age at first live birth 1.15 1 0 0.0 0.00 1.0000 LRRC37A4P
Pulse wave peak to peak time 1.68 1 0 0.0 0.00 1.0000 LOC100505761
Qualifications: College or University degree 1.84 1 1 3.0 0.00 1.0000 LRRC37A4P
Medication for pain relief, constipation, heartburn 2.83 2 0 0.0 0.00 1.0000 LRRC37A4P RAB7L1
Medication: Blood pressure 2.94 1 1 3.0 0.00 1.0000 ULK3
Angina (self-reported) 1.49 1 0 0.0 0.00 1.0000 MARK3
Mean time to correctly identify matches 2.32 2 0 0.0 0.00 1.0000 RAB7L1 VCL
Whole body fat mass 1.47 3 0 0.0 0.00 1.0000 MARK3 NCRNA00181 RAB7L1
Leg fat mass (right) 1.29 1 0 0.0 0.00 1.0000 MARK3
Arm predicted mass (right) 1.82 2 1 3.0 0.00 1.0000 RAB7L1 VCL
Pulse rate, automated reading 1.00 1 0 0.0 0.00 1.0000 RAB7L1
Alcohol intake frequency. 2.78 3 1 3.0 0.00 1.0000 LRRC37A4P ULK3 ZNF318
Comparative height size at age 10 2.61 3 2 6.1 0.00 1.0000 LRRC37A4P MARK3 RAB7L1
Suffer from 'nerves' 2.44 1 0 0.0 0.00 1.0000 LRRC37A4P
Overall health rating 1.42 1 0 0.0 0.00 1.0000 MARK3
Leg pain on walking 1.56 1 0 0.0 0.00 1.0000 LRRC37A4P
Hypertension (Self-reported) 5.88 5 2 6.1 -0.60 0.2898 LOC100505761 LRRC37A4P ULK3 VCL ZNF318
Whole body fat-free mass 1.79 2 1 3.0 0.00 1.0000 RAB7L1 VCL
Leg fat-free mass (right) 1.88 1 1 3.0 0.00 1.0000 RAB7L1
Arm fat percentage (left) 1.77 2 1 3.0 0.00 1.0000 MARK3 NCRNA00181
Average weekly red wine intake 2.06 1 0 0.0 0.00 1.0000 ULK3
Handedness (chirality/laterality): Left-handed 3.00 1 1 3.0 0.00 1.0000 LRRC37A4P
Mood swings 4.13 2 1 3.0 0.00 1.0000 LRRC37A4P RAB7L1
Loneliness, isolation 2.27 1 0 0.0 0.00 1.0000 LRRC37A4P
Long-standing illness, disability or infirmity 1.83 1 0 0.0 0.00 1.0000 MARK3
Diabetes diagnosed by doctor 1.42 1 0 0.0 0.00 1.0000 MARK3
Mouth/teeth dental problems: Mouth ulcers 2.86 1 1 3.0 0.00 1.0000 LRRC37A4P
Medication for cholesterol 3.49 2 0 0.0 0.00 1.0000 LRRC37A4P ZNF318
Mineral and other dietary supplements 3.12 1 0 0.0 0.00 1.0000 RAB7L1
Osteoarthritis (self-reported) 1.91 1 0 0.0 0.00 1.0000 ULK3
Illnesses of father: None of the above (group 1) 3.07 1 0 0.0 0.00 1.0000 VCL
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.10 1 1 3.0 0.00 1.0000 LRRC37A4P
Whole body water mass 1.75 2 1 3.0 0.00 1.0000 RAB7L1 VCL
Leg predicted mass (right) 1.87 1 1 3.0 0.00 1.0000 RAB7L1
Arm fat mass (left) 1.72 3 1 3.0 0.00 1.0000 MARK3 NCRNA00181 RAB7L1
Number of self-reported non-cancer illnesses 3.09 2 0 0.0 0.00 1.0000 MARK3 ZNF318
Average weekly champagne plus white wine intake 3.23 1 0 0.0 0.00 1.0000 LRRC37A4P
Miserableness 2.64 1 1 3.0 0.00 1.0000 LRRC37A4P
Guilty feelings 3.12 1 1 3.0 0.00 1.0000 LRRC37A4P
Hearing aid user 5.21 2 0 0.0 0.00 1.0000 ANKRA2 ARHGEF28
Tinnitus: Yes, now most or all of the time 2.96 1 0 0.0 0.00 1.0000 ZNF318
Medication: Blood pressure 6.46 4 2 6.1 -0.98 0.0157 LRRC37A4P ULK3 VCL ZNF318
Medication: Bendroflumethiazide 3.31 2 0 0.0 0.00 1.0000 ULK3 ZNF318
Medication: Paracetamol 3.38 1 0 0.0 0.00 1.0000 LRRC37A4P
Medication: Lisinopril 2.16 1 0 0.0 0.00 1.0000 ULK3
Basal metabolic rate 1.72 2 1 3.0 0.00 1.0000 RAB7L1 VCL
Leg fat percentage (left) 1.03 1 0 0.0 0.00 1.0000 MARK3
Arm fat-free mass (left) 1.67 2 1 3.0 0.00 1.0000 RAB7L1 VCL
Irritability 1.93 1 0 0.0 0.00 1.0000 LRRC37A4P
Risk taking 2.47 1 0 0.0 0.00 1.0000 MARK3
Diastolic blood pressure, automated reading 4.32 1 1 3.0 0.00 1.0000 ULK3
Myopia 1.33 1 0 0.0 0.00 1.0000 LRRC37A4P
Vascular/heart problems diagnosed by doctor 6.49 4 2 6.1 0.61 0.3878 MARK3 ULK3 VCL ZNF318
Cholesterol lowering medication 1.18 1 0 0.0 0.00 1.0000 ZNF318
Pain experienced in last month 1.71 1 0 0.0 0.00 1.0000 LRRC37A4P
Pack years of smoking 2.57 1 0 0.0 0.00 1.0000 MARK3
Impedance of whole body 2.61 6 1 3.0 0.37 0.4665 LOC100505761 LRRC37A4P MARK3 RAB7L1 VCL ZNF318
Leg fat mass (left) 1.36 1 0 0.0 0.00 1.0000 MARK3
Arm predicted mass (left) 1.66 2 1 3.0 0.00 1.0000 RAB7L1 VCL

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.68
GTEx Adipose Visceral Omentum 0 0.0000 1.58
GTEx Adrenal Gland 0 0.0000 1.64
GTEx Artery Aorta 2 0.0672 1.65
GTEx Artery Coronary 2 0.1691 1.68
GTEx Artery Tibial 2 0.0532 1.65
GTEx Brain Caudate basal ganglia 1 0.1087 1.62
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.52
GTEx Brain Cerebellum 1 0.0505 1.60
GTEx Brain Cortex 0 0.0000 1.77
GTEx Brain Frontal Cortex BA9 0 0.0000 1.62
GTEx Brain Hippocampus 0 0.0000 1.44
GTEx Brain Hypothalamus 0 0.0000 1.48
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.65
GTEx Brain Putamen basal ganglia 1 0.1603 1.51
GTEx Breast Mammary Tissue 2 0.1013 1.68
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.63
GTEx Breast Mammary Tissue (Female) 1 0.0608 1.66
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.60
GTEx Cells Transformed fibroblasts 0 0.0000 1.58
GTEx Colon Sigmoid 2 0.1368 1.63
GTEx Colon Transverse 0 0.0000 1.68
GTEx Esophagus Gastroesophageal Junction 1 0.0692 1.62
GTEx Esophagus Mucosa 1 0.0301 1.67
GTEx Esophagus Muscularis 2 0.0619 1.68
GTEx Heart Atrial Appendage 2 0.1267 1.61
GTEx Heart Left Ventricle 1 0.0654 1.59
GTEx Liver 0 0.0000 1.71
GTEx Lung 1 0.0348 1.65
GTEx Muscle Skeletal 0 0.0000 1.59
GTEx Nerve Tibial 4 0.0926 1.59
GTEx Ovary 0 0.0000 1.69
GTEx Pancreas 1 0.0613 1.71
GTEx Pituitary 1 0.0897 1.68
GTEx Prostate 0 0.0000 1.75
GTEx Skin Not Sun Exposed Suprapubic 1 0.0407 1.73
GTEx Skin Sun Exposed Lower leg 3 0.0824 1.72
GTEx Small Intestine Terminal Ileum 0 0.0000 1.68
GTEx Spleen 2 0.1417 1.69
GTEx Stomach 1 0.0688 1.66
GTEx Testis 2 0.0634 1.68
GTEx Thyroid 2 0.0500 1.69
GTEx Uterus 1 0.1764 1.69
GTEx Vagina 0 0.0000 1.55
GTEx Whole Blood 0 0.0000 1.64
METSIM Adipose 3 0.0651 1.59
NTR Blood 2 0.0833 1.53
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.63
YFS Blood 2 0.0433 1.54
CommonMind Brain Pre-frontal Cortex 3 0.0558 1.60
TCGA Breast Tumor 0 0.0000 1.62
TCGA Breast Normal 2 0.0475 1.46
TCGA Ovarian Tumor 1 0.0342 1.48
TCGA Prostate Tumor 5 0.1446 1.59