Hub : Traits :

Medication: Co-codamol

2 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 49244657 51009435 2 1 9.1e-08 2.7e-06 0.074 86 MST1R

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 12.33 1 1 3 0 1 MST1R
Irritable Bowel Disease (IBD) 22.32 1 1 3 0 1 MST1R
Ulcerative Colitis (UC) 23.13 1 1 3 0 1 MST1R
Major Depression (MDD) 8.27 1 0 0 0 1 MST1R
Verbal and Numeric Reasoning (VNR) 25.47 1 1 3 0 1 MST1R
Prostate Cancer 9.37 1 0 0 0 1 MST1R
Age at First Birth 45.07 1 1 3 0 1 MST1R
Body Mass Index (BMI) (2010) 8.14 1 0 0 0 1 MST1R
Coronary Artery Disease (CAD) 10.53 1 0 0 0 1 MST1R
Crohns Disease (2012) 15.36 1 0 0 0 1 MST1R
HbA1C 5.33 1 0 0 0 1 MST1R
HDL Cholesterol 3.16 1 0 0 0 1 MST1R
Neuroticism 5.09 1 0 0 0 1 MST1R
Ulcerative Colitis 18.30 1 1 3 0 1 MST1R
Blood White Count 5.60 1 1 3 0 1 MST1R
Heel T-Score 1.91 1 0 0 0 1 MST1R
BMI 27.57 1 1 3 0 1 MST1R
Height 2.43 1 1 3 0 1 MST1R
Waist Hip Ratio (WHR) 1.14 1 0 0 0 1 MST1R
Smoking Status 7.20 1 0 0 0 1 MST1R
Cardiovascular Disease 1.73 1 0 0 0 1 MST1R
Respiratory disease 5.64 1 0 0 0 1 MST1R
Type 2 Diabetes (T2D) 6.42 1 0 0 0 1 MST1R
Lung FEV1/FVC ratio 2.20 1 0 0 0 1 MST1R
Lung FVC 3.80 1 0 0 0 1 MST1R
Neuroticism 7.95 1 0 0 0 1 MST1R
Tanning 0.66 1 0 0 0 1 MST1R
Number of treatments/medications taken 17.08 1 1 3 0 1 MST1R
Frequency of depressed mood in last 2 weeks 3.61 1 0 0 0 1 MST1R
Relative age of first facial hair 3.70 1 0 0 0 1 MST1R
Ever had hysterectomy (womb removed) 6.70 1 0 0 0 1 MST1R
Systolic blood pressure, automated reading 2.45 1 0 0 0 1 MST1R
Medication: Metformin 3.99 1 0 0 0 1 MST1R
Diabetes (mother) 4.58 1 0 0 0 1 MST1R
Pack years adult smoking proportion 3.55 1 0 0 0 1 MST1R
Impedance of leg (right) 10.02 1 1 3 0 1 MST1R
Leg fat-free mass (left) 8.87 1 1 3 0 1 MST1R
Trunk fat percentage 9.95 1 1 3 0 1 MST1R
Hand grip strength (right) 2.30 1 0 0 0 1 MST1R
Current tobacco smoking 3.73 1 0 0 0 1 MST1R
Fed-up feelings 19.60 1 1 3 0 1 MST1R
Frequency of unenthusiasm / disinterest in last 2 weeks 7.05 1 0 0 0 1 MST1R
Taking other prescription medications 16.53 1 1 3 0 1 MST1R
Age when periods started (menarche) 5.44 1 0 0 0 1 MST1R
Bilateral oophorectomy (both ovaries removed) 8.65 1 0 0 0 1 MST1R
Heel bone mineral density (BMD) T-score, automated (left) 2.95 1 0 0 0 1 MST1R
Qualifications: CSEs or equivalent 12.58 1 0 0 0 1 MST1R
Chronic bronchitis/emphysema (father) 6.00 1 0 0 0 1 MST1R
Body mass index (BMI) 31.84 1 1 3 0 1 MST1R
Impedance of leg (left) 11.52 1 1 3 0 1 MST1R
Leg predicted mass (left) 8.71 1 1 3 0 1 MST1R
Trunk fat mass 13.40 1 1 3 0 1 MST1R
Waist circumference 14.80 1 1 3 0 1 MST1R
Alcohol usually taken with meals 6.83 1 0 0 0 1 MST1R
Frequency of tenseness / restlessness in last 2 weeks 8.92 1 0 0 0 1 MST1R
Forced vital capacity (FVC) 5.29 1 0 0 0 1 MST1R
Ever unenthusiastic/disinterested for a whole week 10.86 1 0 0 0 1 MST1R
Qualifications: None of the above 26.89 1 1 3 0 1 MST1R
Mouth/teeth dental problems 3.49 1 0 0 0 1 MST1R
Heart attack 6.34 1 0 0 0 1 MST1R
Pain all over the body in last month 14.78 1 0 0 0 1 MST1R
Diabetes (self-reported) 9.12 1 0 0 0 1 MST1R
Fluid intelligence score 26.93 1 1 3 0 1 MST1R
Illnesses of siblings 6.48 1 0 0 0 1 MST1R
Neuroticism score 9.02 1 0 0 0 1 MST1R
Weight 15.82 1 1 3 0 1 MST1R
Impedance of arm (right) 23.66 1 1 3 0 1 MST1R
Arm fat percentage (right) 17.97 1 1 3 0 1 MST1R
Trunk fat-free mass 6.26 1 1 3 0 1 MST1R
Hip circumference 12.53 1 1 3 0 1 MST1R
Alcohol intake versus 10 years previously 13.41 1 0 0 0 1 MST1R
Father's age at death 7.38 1 0 0 0 1 MST1R
Number of live births 7.83 1 0 0 0 1 MST1R
Forced expiratory volume in 1-second (FEV1) 7.23 1 0 0 0 1 MST1R
Noisy workplace 5.77 1 0 0 0 1 MST1R
Qualifications: A levels/AS levels or equivalent 35.79 1 1 3 0 1 MST1R
Mouth/teeth dental problems: Dentures 12.77 1 0 0 0 1 MST1R
Asthma 4.95 1 0 0 0 1 MST1R
Medication: Cholesterol lowering 5.35 1 0 0 0 1 MST1R
Forced expiratory volume in 1-second (FEV1), Best measure 8.65 1 1 3 0 1 MST1R
Impedance of arm (left) 24.22 1 1 3 0 1 MST1R
Arm fat mass (right) 22.35 1 1 3 0 1 MST1R
Trunk predicted mass 6.12 1 1 3 0 1 MST1R
Standing height 2.13 1 0 0 0 1 MST1R
Exposure to tobacco smoke at home 18.67 1 0 0 0 1 MST1R
Breastfed as a baby 4.53 1 0 0 0 1 MST1R
Seen doctor (GP) for nerves, anxiety, tension or depression 6.12 1 0 0 0 1 MST1R
Peak expiratory flow (PEF) 5.07 1 0 0 0 1 MST1R
Ever highly irritable/argumentative for 2 days 23.06 1 1 3 0 1 MST1R
Qualifications: O levels/GCSEs or equivalent 9.65 1 0 0 0 1 MST1R
Medication: Paracetamol 5.21 1 0 0 0 1 MST1R
Medication for cholesterol, blood pressure or diabetes 10.22 1 0 0 0 1 MST1R
Medication: Ventolin 100micrograms inhaler 7.98 1 0 0 0 1 MST1R
Chronic bronchitis/emphysema (mother) 10.88 1 0 0 0 1 MST1R
High blood pressure (siblings) 5.80 1 0 0 0 1 MST1R
Forced vital capacity (FVC), Best measure 6.80 1 0 0 0 1 MST1R
Body fat percentage 14.59 1 1 3 0 1 MST1R
Leg fat percentage (right) 23.44 1 1 3 0 1 MST1R
Arm fat-free mass (right) 10.98 1 1 3 0 1 MST1R
Exposure to tobacco smoke outside home 12.75 1 0 0 0 1 MST1R
Comparative body size at age 10 3.56 1 0 0 0 1 MST1R
Number of full brothers 11.71 1 0 0 0 1 MST1R
Wheeze or whistling in the chest in last year 17.64 1 1 3 0 1 MST1R
Reason for reducing amount of alcohol drunk: Health precaution 4.75 1 0 0 0 1 MST1R
Age at first live birth 31.63 1 1 3 0 1 MST1R
Health satisfaction 4.95 1 0 0 0 1 MST1R
Shortness of breath walking on level ground 5.01 1 0 0 0 1 MST1R
Qualifications: College or University degree 44.27 1 1 3 0 1 MST1R
Medication for pain relief, constipation, heartburn 3.98 1 0 0 0 1 MST1R
Neck or shoulder pain in last month 4.90 1 0 0 0 1 MST1R
Medication: Blood pressure 6.80 1 0 0 0 1 MST1R
Medication: Ibuprofen 4.45 1 0 0 0 1 MST1R
Medication: Omeprazole 5.08 1 0 0 0 1 MST1R
Medication: Seretide 50 evohaler 17.40 1 0 0 0 1 MST1R
Mean time to correctly identify matches 3.35 1 0 0 0 1 MST1R
Whole body fat mass 18.93 1 1 3 0 1 MST1R
Leg fat mass (right) 25.64 1 1 3 0 1 MST1R
Arm predicted mass (right) 11.90 1 1 3 0 1 MST1R
Alcohol intake frequency. 8.76 1 0 0 0 1 MST1R
Comparative height size at age 10 3.45 1 0 0 0 1 MST1R
Number of full sisters 7.23 1 0 0 0 1 MST1R
Overall health rating 25.20 1 1 3 0 1 MST1R
Chest pain or discomfort 6.42 1 0 0 0 1 MST1R
Had major operations 8.82 1 0 0 0 1 MST1R
Age at last live birth 37.48 1 1 3 0 1 MST1R
Leg pain on walking 9.18 1 0 0 0 1 MST1R
Qualifications: NVQ or HND or HNC or equivalent 8.92 1 0 0 0 1 MST1R
Commuting to job workplace: Car/motor vehicle 6.80 1 0 0 0 1 MST1R
Knee pain experienced in last month 9.32 1 0 0 0 1 MST1R
Illnesses of siblings: Diabetes 4.77 1 0 0 0 1 MST1R
Whole body fat-free mass 7.81 1 1 3 0 1 MST1R
Leg fat-free mass (right) 6.93 1 1 3 0 1 MST1R
Arm fat percentage (left) 17.84 1 1 3 0 1 MST1R
Average weekly red wine intake 7.65 1 0 0 0 1 MST1R
Mood swings 15.28 1 1 3 0 1 MST1R
Loneliness, isolation 8.48 1 0 0 0 1 MST1R
Ever had bowel cancer screening 8.19 1 0 0 0 1 MST1R
Diabetes diagnosed by doctor 6.77 1 0 0 0 1 MST1R
Qualifications: nursing, teaching 9.31 1 0 0 0 1 MST1R
Commuting to job workplace: Walk 4.98 1 0 0 0 1 MST1R
Asthma (self-reported) 5.19 1 0 0 0 1 MST1R
Osteoarthritis (self-reported) 6.41 1 0 0 0 1 MST1R
Forced expiratory volume in 1-second (FEV1), predicted percentage 5.80 1 0 0 0 1 MST1R
Whole body water mass 8.11 1 1 3 0 1 MST1R
Leg predicted mass (right) 6.80 1 1 3 0 1 MST1R
Arm fat mass (left) 22.03 1 1 3 0 1 MST1R
Miserableness 24.41 1 1 3 0 1 MST1R
Guilty feelings 14.59 1 0 0 0 1 MST1R
Ever taken oral contraceptive pill 4.92 1 0 0 0 1 MST1R
Mother's age at death 5.18 1 0 0 0 1 MST1R
Financial situation satisfaction 8.45 1 0 0 0 1 MST1R
Commuting to job workplace: Public transport 5.51 1 0 0 0 1 MST1R
Medication: Paracetamol 6.81 1 0 0 0 1 MST1R
Basal metabolic rate 10.18 1 1 3 0 1 MST1R
Leg fat percentage (left) 22.61 1 1 3 0 1 MST1R
Arm fat-free mass (left) 12.65 1 1 3 0 1 MST1R
Number of operations (self-reported) 11.86 1 0 0 0 1 MST1R
Average weekly beer plus cider intake 18.78 1 1 3 0 1 MST1R
Age started oral contraceptive pill 12.91 1 0 0 0 1 MST1R
Diastolic blood pressure, automated reading 5.43 1 0 0 0 1 MST1R
Ever depressed for a whole week 13.01 1 0 0 0 1 MST1R
Commuting to job workplace: Cycle 5.14 1 0 0 0 1 MST1R
Vascular/heart problems diagnosed by doctor 1.91 1 0 0 0 1 MST1R
Pain experienced in last month 11.47 1 0 0 0 1 MST1R
Basal cell carcinoma (self-reported) 8.95 1 0 0 0 1 MST1R
Heart attack/myocardial infarction (self-reported) 5.17 1 0 0 0 1 MST1R
Alcohol drinker status: Previous 6.86 1 0 0 0 1 MST1R
Impedance of whole body 19.98 1 1 3 0 1 MST1R
Leg fat mass (left) 25.40 1 1 3 0 1 MST1R
Arm predicted mass (left) 12.85 1 1 3 0 1 MST1R

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.15
GTEx Adipose Visceral Omentum 0 0.0000 1.18
GTEx Adrenal Gland 0 0.0000 1.13
GTEx Artery Aorta 0 0.0000 1.17
GTEx Artery Coronary 0 0.0000 1.18
GTEx Artery Tibial 0 0.0000 1.19
GTEx Brain Caudate basal ganglia 0 0.0000 1.23
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.14
GTEx Brain Cerebellum 0 0.0000 1.16
GTEx Brain Cortex 0 0.0000 1.23
GTEx Brain Frontal Cortex BA9 0 0.0000 1.24
GTEx Brain Hippocampus 0 0.0000 1.14
GTEx Brain Hypothalamus 0 0.0000 1.18
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.13
GTEx Brain Putamen basal ganglia 0 0.0000 1.14
GTEx Breast Mammary Tissue 0 0.0000 1.22
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.12
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.15
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.15
GTEx Cells Transformed fibroblasts 0 0.0000 1.18
GTEx Colon Sigmoid 1 0.0684 1.19
GTEx Colon Transverse 0 0.0000 1.18
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.25
GTEx Esophagus Mucosa 0 0.0000 1.21
GTEx Esophagus Muscularis 1 0.0309 1.22
GTEx Heart Atrial Appendage 0 0.0000 1.18
GTEx Heart Left Ventricle 0 0.0000 1.13
GTEx Liver 0 0.0000 1.20
GTEx Lung 0 0.0000 1.18
GTEx Muscle Skeletal 0 0.0000 1.16
GTEx Nerve Tibial 0 0.0000 1.16
GTEx Ovary 0 0.0000 1.17
GTEx Pancreas 0 0.0000 1.19
GTEx Pituitary 0 0.0000 1.08
GTEx Prostate 0 0.0000 1.16
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.23
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.22
GTEx Small Intestine Terminal Ileum 0 0.0000 1.14
GTEx Spleen 0 0.0000 1.11
GTEx Stomach 0 0.0000 1.18
GTEx Testis 0 0.0000 1.12
GTEx Thyroid 0 0.0000 1.19
GTEx Uterus 0 0.0000 1.22
GTEx Vagina 0 0.0000 1.11
GTEx Whole Blood 0 0.0000 1.17
METSIM Adipose 0 0.0000 1.18
NTR Blood 0 0.0000 1.15
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.22
YFS Blood 0 0.0000 1.16
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.19
TCGA Breast Tumor 0 0.0000 1.10
TCGA Breast Normal 0 0.0000 1.11
TCGA Ovarian Tumor 0 0.0000 1.13
TCGA Prostate Tumor 0 0.0000 1.14