Hub : Traits :

Number of operations (self-reported)

22 significantly associated models · 8 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 49244657 50620043 1 1 1.8e-07 8.2e-07 0.2170 94 MST1R
2 4 105598022 107092169 1 2 4.2e-10 4.5e-12 0.0046 83 PPA2
3 6 147140769 148587096 1 1 3.5e-07 3.7e-06 0.9610 100 SAMD5
4 7 2032803 3510741 1 1 5.1e-08 8.0e-08 0.0115 78 AMZ1
5 10 21087485 22724472 2 2 6.8e-09 3.9e-08 0.0930 91 CASC10 MLLT10
6 11 29646947 31048683 1 1 1.7e-09 2.1e-08 0.1450 93 ARL14EP
7 22 50085456 51219006 1 1 1.5e-07 1.5e-05 0.0230 72 PPP6R2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 1.01 1 0 0.0 0.00 1.00000 MST1R
Irritable Bowel Disease (IBD) 3.69 2 2 6.1 0.00 1.00000 AMZ1 MST1R
Ulcerative Colitis (UC) 6.30 3 2 6.1 0.00 1.00000 AMZ1 MST1R PPA2
Reaction Time 3.22 3 0 0.0 -0.35 0.64880 AMZ1 CASC10 PPA2
Verbal and Numeric Reasoning (VNR) 4.82 2 2 6.1 0.00 1.00000 MST1R PPA2
Breast Cancer 3.39 1 1 3.0 0.00 1.00000 MLLT10
Ovarian Cancer 4.86 2 1 3.0 0.00 1.00000 CASC10 MLLT10
Prostate Cancer 3.03 2 0 0.0 0.00 1.00000 MST1R PPA2
Age at First Birth 4.83 1 1 3.0 0.00 1.00000 MST1R
Body Mass Index (BMI) (2010) 2.25 1 0 0.0 0.00 1.00000 MST1R
Crohns Disease (2012) 1.31 1 0 0.0 0.00 1.00000 MST1R
Schizophrenia 0.96 1 0 0.0 0.00 1.00000 ARL14EP
Ulcerative Colitis 6.12 3 2 6.1 0.00 1.00000 AMZ1 MST1R PPA2
Blood Eosinophil Count 0.78 2 0 0.0 0.00 1.00000 AMZ1 MST1R
Blood Platelet Count 2.36 4 2 6.1 -0.13 0.87465 AMZ1 MLLT10 PPP6R2 SAMD5
Blood Red Count 0.46 1 0 0.0 0.00 1.00000 ARL14EP
Blood White Count 2.31 5 2 6.1 0.13 0.80756 AMZ1 ARL14EP MST1R PPA2 PPP6R2
Heel T-Score 1.28 3 1 3.0 0.00 1.00000 AMZ1 ARL14EP CASC10
BMI 5.71 5 4 12.1 -0.93 0.02430 ARL14EP CASC10 MLLT10 MST1R SAMD5
Height 8.27 3 2 6.1 -0.79 0.20804 AMZ1 CASC10 PPA2
Waist Hip Ratio (WHR) 0.65 1 0 0.0 0.00 1.00000 ARL14EP
Systolic Blood Pressure 0.97 1 0 0.0 0.00 1.00000 PPA2
Smoking Status 3.71 3 1 3.0 0.00 1.00000 CASC10 MLLT10 MST1R
Allergy or Eczema 1.32 1 0 0.0 0.00 1.00000 AMZ1
Cardiovascular Disease 1.51 2 0 0.0 0.00 1.00000 ARL14EP MLLT10
Respiratory disease 1.78 1 0 0.0 0.00 1.00000 MST1R
Type 2 Diabetes (T2D) 2.49 2 0 0.0 0.00 1.00000 ARL14EP MST1R
Lung FEV1/FVC ratio 5.30 4 3 9.1 0.23 0.70984 AMZ1 ARL14EP MLLT10 PPA2
Lung FVC 2.85 7 1 3.0 0.65 0.11608 AMZ1 ARL14EP CASC10 MLLT10 MST1R PPA2 SAMD5
Neuroticism 3.23 3 0 0.0 0.00 1.00000 MLLT10 MST1R SAMD5
Chronotype (morning person) 3.60 2 0 0.0 0.00 1.00000 MST1R SAMD5
Hand grip strength (left) 1.60 2 0 0.0 0.00 1.00000 AMZ1 MLLT10
Number of treatments/medications taken 4.99 3 0 0.0 0.00 1.00000 MLLT10 MST1R SAMD5
Sensitivity / hurt feelings 2.34 1 0 0.0 0.00 1.00000 PPA2
Relative age of first facial hair 1.41 1 0 0.0 0.00 1.00000 MST1R
Other serious medical condition/disability diagnosed by doctor 3.14 1 0 0.0 0.00 1.00000 PPA2
Ever used hormone-replacement therapy (HRT) 2.76 1 0 0.0 0.00 1.00000 ARL14EP
Ever had hysterectomy (womb removed) 5.28 3 0 0.0 0.00 1.00000 ARL14EP MLLT10 MST1R
Systolic blood pressure, automated reading 1.85 2 0 0.0 0.00 1.00000 MST1R PPA2
Medication: Co-codamol 3.72 1 0 0.0 0.00 1.00000 MST1R
Medication: Metformin 1.63 1 0 0.0 0.00 1.00000 PPP6R2
Diabetes (mother) 1.54 1 0 0.0 0.00 1.00000 PPP6R2
Impedance of leg (right) 2.19 2 1 3.0 0.00 1.00000 MST1R PPA2
Leg fat-free mass (left) 8.15 6 3 9.1 0.91 0.00412 AMZ1 ARL14EP CASC10 MLLT10 MST1R PPA2
Trunk fat percentage 4.78 5 2 6.1 0.94 0.01943 AMZ1 ARL14EP CASC10 MLLT10 MST1R
Hand grip strength (right) 1.98 2 0 0.0 0.00 1.00000 AMZ1 MLLT10
Current tobacco smoking 1.56 1 0 0.0 0.00 1.00000 MST1R
Maternal smoking around birth 3.89 2 0 0.0 0.00 1.00000 MLLT10 MST1R
Fed-up feelings 2.17 1 0 0.0 0.00 1.00000 MST1R
Taking other prescription medications 4.70 3 1 3.0 0.00 1.00000 MLLT10 MST1R SAMD5
Age when periods started (menarche) 3.34 1 1 3.0 0.00 1.00000 MST1R
Bilateral oophorectomy (both ovaries removed) 6.36 4 0 0.0 1.00 0.00090 ARL14EP CASC10 MLLT10 MST1R
Qualifications: CSEs or equivalent 2.70 1 0 0.0 0.00 1.00000 MST1R
High blood pressure 1.27 2 0 0.0 0.00 1.00000 ARL14EP MLLT10
Hayfever, allergic rhinitis or eczema 1.22 1 0 0.0 0.00 1.00000 AMZ1
Stomach or abdominal pain in last month 3.67 1 0 0.0 0.00 1.00000 PPA2
Sitting height 8.36 3 2 6.1 0.91 0.09274 AMZ1 MLLT10 PPA2
Body mass index (BMI) 5.88 4 3 9.1 0.94 0.06344 ARL14EP CASC10 MLLT10 MST1R
Impedance of leg (left) 2.68 2 1 3.0 0.00 1.00000 MST1R PPA2
Leg predicted mass (left) 8.12 6 3 9.1 0.91 0.00430 AMZ1 ARL14EP CASC10 MLLT10 MST1R PPA2
Trunk fat mass 7.00 5 4 12.1 0.94 0.01887 AMZ1 ARL14EP CASC10 MLLT10 MST1R
Waist circumference 7.04 5 5 15.2 0.98 0.00265 AMZ1 ARL14EP CASC10 MLLT10 MST1R
Past tobacco smoking 4.09 3 0 0.0 0.00 1.00000 CASC10 MLLT10 MST1R
Frequency of tenseness / restlessness in last 2 weeks 2.62 1 0 0.0 0.00 1.00000 MST1R
Had other major operations 7.34 2 0 0.0 0.00 1.00000 ARL14EP PPA2
Forced vital capacity (FVC) 4.78 4 2 6.1 0.38 0.52297 AMZ1 MLLT10 MST1R PPA2
Ever unenthusiastic/disinterested for a whole week 3.19 2 0 0.0 0.00 1.00000 MST1R SAMD5
Qualifications: None of the above 4.89 2 1 3.0 0.00 1.00000 MST1R PPA2
Allergy 1.43 1 0 0.0 0.00 1.00000 AMZ1
Pain all over the body in last month 3.52 2 0 0.0 0.00 1.00000 MST1R SAMD5
Fluid intelligence score 5.93 2 2 6.1 0.00 1.00000 MST1R PPA2
Neuroticism score 3.27 4 0 0.0 0.68 0.32475 MLLT10 MST1R PPA2 SAMD5
Weight 8.50 6 5 15.2 0.95 0.00311 AMZ1 ARL14EP CASC10 MLLT10 MST1R PPA2
Impedance of arm (right) 4.52 6 1 3.0 -0.65 0.15926 AMZ1 ARL14EP CASC10 MLLT10 MST1R SAMD5
Arm fat percentage (right) 4.19 5 2 6.1 0.95 0.01158 AMZ1 ARL14EP CASC10 MLLT10 MST1R
Trunk fat-free mass 7.29 5 3 9.1 0.90 0.01328 AMZ1 ARL14EP CASC10 MST1R PPA2
Hip circumference 7.37 6 4 12.1 0.95 0.00378 AMZ1 ARL14EP CASC10 MLLT10 MST1R PPA2
Alcohol intake versus 10 years previously 3.71 2 0 0.0 0.00 1.00000 MLLT10 MST1R
Worrier / anxious feelings 1.62 1 0 0.0 0.00 1.00000 MLLT10
Frequency of tiredness / lethargy in last 2 weeks 2.58 2 0 0.0 0.00 1.00000 AMZ1 SAMD5
Number of live births 2.12 1 0 0.0 0.00 1.00000 MST1R
Forced expiratory volume in 1-second (FEV1) 4.63 2 1 3.0 0.00 1.00000 MST1R PPA2
Pulse rate 1.70 1 0 0.0 0.00 1.00000 ARL14EP
Qualifications: A levels/AS levels or equivalent 5.39 2 1 3.0 0.00 1.00000 MST1R PPA2
Mouth/teeth dental problems: Dentures 2.20 1 0 0.0 0.00 1.00000 MST1R
Asthma 1.85 2 0 0.0 0.00 1.00000 MLLT10 MST1R
Forced expiratory volume in 1-second (FEV1), Best measure 5.46 2 1 3.0 0.00 1.00000 MST1R PPA2
Impedance of arm (left) 4.66 6 2 6.1 -0.60 0.20869 AMZ1 ARL14EP CASC10 MLLT10 MST1R PPA2
Arm fat mass (right) 6.34 5 3 9.1 0.96 0.00792 AMZ1 ARL14EP CASC10 MLLT10 MST1R
Trunk predicted mass 7.28 5 3 9.1 0.90 0.01368 AMZ1 ARL14EP CASC10 MST1R PPA2
Standing height 8.21 2 2 6.1 0.00 1.00000 AMZ1 PPA2
Exposure to tobacco smoke at home 3.89 1 0 0.0 0.00 1.00000 MST1R
Tense / 'highly strung' 3.65 1 1 3.0 0.00 1.00000 SAMD5
Seen doctor (GP) for nerves, anxiety, tension or depression 4.69 2 1 3.0 0.00 1.00000 PPA2 SAMD5
Birth weight of first child 5.48 2 1 3.0 0.00 1.00000 AMZ1 PPA2
Peak expiratory flow (PEF) 1.98 2 0 0.0 0.00 1.00000 MLLT10 PPA2
Pulse wave reflection index 1.49 1 0 0.0 0.00 1.00000 MST1R
Ever highly irritable/argumentative for 2 days 3.56 1 0 0.0 0.00 1.00000 MST1R
Qualifications: O levels/GCSEs or equivalent 2.28 1 0 0.0 0.00 1.00000 MST1R
Mouth/teeth dental problems: Bleeding gums 2.54 1 0 0.0 0.00 1.00000 PPA2
Medication: Paracetamol 3.36 2 0 0.0 0.00 1.00000 MLLT10 MST1R
Birth weight 4.94 3 1 3.0 0.00 1.00000 AMZ1 PPA2 PPP6R2
Chronic bronchitis/emphysema (mother) 3.49 2 0 0.0 0.00 1.00000 MLLT10 MST1R
Forced vital capacity (FVC), Best measure 5.32 4 3 9.1 0.36 0.54719 AMZ1 MLLT10 MST1R PPA2
Body fat percentage 4.94 5 4 12.1 0.96 0.01075 AMZ1 ARL14EP CASC10 MLLT10 MST1R
Leg fat percentage (right) 6.21 4 3 9.1 0.95 0.04867 ARL14EP CASC10 MLLT10 MST1R
Arm fat-free mass (right) 7.40 6 4 12.1 0.95 0.00116 AMZ1 ARL14EP CASC10 MLLT10 MST1R PPA2
Exposure to tobacco smoke outside home 2.61 1 0 0.0 0.00 1.00000 MST1R
Comparative body size at age 10 1.22 2 0 0.0 0.00 1.00000 ARL14EP MST1R
Number of full brothers 3.13 1 0 0.0 0.00 1.00000 MST1R
Worry too long after embarrassment 3.66 2 0 0.0 0.00 1.00000 MLLT10 PPA2
Seen a psychiatrist for nerves, anxiety, tension or depression 4.01 1 0 0.0 0.00 1.00000 SAMD5
Wheeze or whistling in the chest in last year 3.17 2 0 0.0 0.00 1.00000 AMZ1 MST1R
Number of children fathered 1.82 1 0 0.0 0.00 1.00000 MST1R
Reason for reducing amount of alcohol drunk: Health precaution 1.91 1 0 0.0 0.00 1.00000 PPA2
Age at first live birth 4.70 1 1 3.0 0.00 1.00000 MST1R
Qualifications: College or University degree 8.01 3 2 6.1 -0.67 0.33215 MLLT10 MST1R PPA2
Medication for pain relief, constipation, heartburn 2.99 1 0 0.0 0.00 1.00000 MLLT10
Neck or shoulder pain in last month 1.47 1 0 0.0 0.00 1.00000 MST1R
Medication: Omeprazole 3.85 2 0 0.0 0.00 1.00000 MST1R SAMD5
Mean time to correctly identify matches 2.87 1 0 0.0 0.00 1.00000 PPA2
Whole body fat mass 7.12 5 4 12.1 0.96 0.00941 AMZ1 ARL14EP CASC10 MLLT10 MST1R
Leg fat mass (right) 7.63 5 5 15.2 0.97 0.00781 AMZ1 ARL14EP CASC10 MLLT10 MST1R
Arm predicted mass (right) 7.71 6 4 12.1 0.95 0.00112 AMZ1 ARL14EP CASC10 MLLT10 MST1R PPA2
Pulse rate, automated reading 1.00 1 0 0.0 0.00 1.00000 ARL14EP
Alcohol intake frequency. 1.79 1 0 0.0 0.00 1.00000 PPA2
Comparative height size at age 10 5.20 3 2 6.1 0.00 1.00000 AMZ1 MST1R PPA2
Overall health rating 4.30 3 1 3.0 0.00 1.00000 AMZ1 MLLT10 MST1R
Chest pain or discomfort 1.99 1 0 0.0 0.00 1.00000 SAMD5
Had major operations 7.05 3 0 0.0 0.00 1.00000 AMZ1 CASC10 MST1R
Age at last live birth 4.66 1 1 3.0 0.00 1.00000 MST1R
Leg pain on walking 2.77 1 0 0.0 0.00 1.00000 MST1R
Commuting to job workplace: Car/motor vehicle 2.98 1 0 0.0 0.00 1.00000 MST1R
Knee pain experienced in last month 3.27 2 0 0.0 0.00 1.00000 AMZ1 MST1R
Hypertension (Self-reported) 1.38 2 0 0.0 0.00 1.00000 ARL14EP MLLT10
Smoking status: Previous 3.56 3 0 0.0 0.00 1.00000 CASC10 MLLT10 MST1R
Forced expiratory volume in 1-second (FEV1), predicted 3.99 2 1 3.0 0.00 1.00000 AMZ1 PPA2
Whole body fat-free mass 7.80 6 3 9.1 0.91 0.00461 AMZ1 ARL14EP CASC10 MLLT10 MST1R PPA2
Leg fat-free mass (right) 7.53 5 3 9.1 0.90 0.01452 AMZ1 CASC10 MLLT10 MST1R PPA2
Arm fat percentage (left) 4.45 5 3 9.1 0.96 0.00996 AMZ1 ARL14EP CASC10 MLLT10 MST1R
Mood swings 2.42 1 0 0.0 0.00 1.00000 MST1R
Loneliness, isolation 3.56 2 0 0.0 0.00 1.00000 MST1R PPA2
Ever had bowel cancer screening 3.83 2 0 0.0 0.00 1.00000 MLLT10 MST1R
Diabetes diagnosed by doctor 1.94 1 0 0.0 0.00 1.00000 ARL14EP
Friendships satisfaction 1.86 1 0 0.0 0.00 1.00000 PPA2
Qualifications: nursing, teaching 2.94 2 0 0.0 0.00 1.00000 MST1R PPA2
Commuting to job workplace: Walk 3.82 1 0 0.0 0.00 1.00000 MST1R
Breast cancer (self-reported) 4.21 2 0 0.0 0.00 1.00000 CASC10 MLLT10
Asthma (self-reported) 1.74 1 0 0.0 0.00 1.00000 MST1R
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.56 3 1 3.0 0.00 1.00000 AMZ1 MST1R PPA2
Whole body water mass 7.76 6 3 9.1 0.91 0.00415 AMZ1 ARL14EP CASC10 MLLT10 MST1R PPA2
Leg predicted mass (right) 7.53 6 3 9.1 0.89 0.00670 AMZ1 ARL14EP CASC10 MLLT10 MST1R PPA2
Arm fat mass (left) 6.53 5 3 9.1 0.96 0.00828 AMZ1 ARL14EP CASC10 MLLT10 MST1R
Number of self-reported non-cancer illnesses 3.65 2 0 0.0 0.00 1.00000 ARL14EP MLLT10
Miserableness 3.28 1 1 3.0 0.00 1.00000 MST1R
Guilty feelings 3.45 2 0 0.0 0.00 1.00000 MST1R PPA2
Financial situation satisfaction 2.77 1 0 0.0 0.00 1.00000 MST1R
Commuting to job workplace: Public transport 3.35 1 0 0.0 0.00 1.00000 PPA2
Medication: Paracetamol 3.16 2 0 0.0 0.00 1.00000 MLLT10 MST1R
Ever smoked 4.12 3 0 0.0 0.00 1.00000 MST1R PPA2 PPP6R2
Basal metabolic rate 8.15 6 3 9.1 0.93 0.00276 AMZ1 ARL14EP CASC10 MLLT10 MST1R PPA2
Leg fat percentage (left) 5.92 4 3 9.1 0.95 0.04785 ARL14EP CASC10 MLLT10 MST1R
Arm fat-free mass (left) 7.65 6 4 12.1 0.95 0.00082 AMZ1 ARL14EP CASC10 MLLT10 MST1R PPA2
Average weekly beer plus cider intake 3.43 1 1 3.0 0.00 1.00000 MST1R
Irritability 3.66 2 0 0.0 0.00 1.00000 PPA2 SAMD5
Fractured/broken bones in last 5 years 2.85 1 0 0.0 0.00 1.00000 PPA2
Diastolic blood pressure, automated reading 1.89 2 0 0.0 0.00 1.00000 MLLT10 MST1R
Ever depressed for a whole week 2.26 1 0 0.0 0.00 1.00000 MST1R
Vascular/heart problems diagnosed by doctor 1.70 2 0 0.0 0.00 1.00000 ARL14EP MLLT10
Medication: Omeprazole (e.g. Zanprol) 3.28 1 0 0.0 0.00 1.00000 SAMD5
Pain experienced in last month 3.71 2 0 0.0 0.00 1.00000 MLLT10 MST1R
Heart attack/myocardial infarction (self-reported) 2.33 1 0 0.0 0.00 1.00000 SAMD5
Pack years of smoking 1.37 1 0 0.0 0.00 1.00000 ARL14EP
Impedance of whole body 3.72 5 1 3.0 -0.91 0.03245 ARL14EP CASC10 MLLT10 MST1R PPA2
Leg fat mass (left) 7.35 5 4 12.1 0.96 0.00836 AMZ1 ARL14EP CASC10 MLLT10 MST1R
Arm predicted mass (left) 7.76 6 4 12.1 0.95 0.00094 AMZ1 ARL14EP CASC10 MLLT10 MST1R PPA2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.55
GTEx Adipose Visceral Omentum 0 0.0000 1.60
GTEx Adrenal Gland 0 0.0000 1.49
GTEx Artery Aorta 0 0.0000 1.58
GTEx Artery Coronary 0 0.0000 1.64
GTEx Artery Tibial 1 0.0266 1.52
GTEx Brain Caudate basal ganglia 0 0.0000 1.56
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.45
GTEx Brain Cerebellum 1 0.0505 1.58
GTEx Brain Cortex 1 0.0966 1.59
GTEx Brain Frontal Cortex BA9 0 0.0000 1.59
GTEx Brain Hippocampus 0 0.0000 1.49
GTEx Brain Hypothalamus 0 0.0000 1.47
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.54
GTEx Brain Putamen basal ganglia 0 0.0000 1.55
GTEx Breast Mammary Tissue 0 0.0000 1.59
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.49
GTEx Breast Mammary Tissue (Female) 1 0.0608 1.52
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.60
GTEx Cells Transformed fibroblasts 1 0.0238 1.53
GTEx Colon Sigmoid 1 0.0684 1.61
GTEx Colon Transverse 0 0.0000 1.57
GTEx Esophagus Gastroesophageal Junction 2 0.1384 1.63
GTEx Esophagus Mucosa 1 0.0301 1.50
GTEx Esophagus Muscularis 1 0.0309 1.54
GTEx Heart Atrial Appendage 1 0.0633 1.61
GTEx Heart Left Ventricle 0 0.0000 1.54
GTEx Liver 0 0.0000 1.44
GTEx Lung 0 0.0000 1.55
GTEx Muscle Skeletal 0 0.0000 1.52
GTEx Nerve Tibial 1 0.0231 1.53
GTEx Ovary 1 0.1101 1.56
GTEx Pancreas 1 0.0613 1.62
GTEx Pituitary 0 0.0000 1.51
GTEx Prostate 0 0.0000 1.55
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.55
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.54
GTEx Small Intestine Terminal Ileum 0 0.0000 1.63
GTEx Spleen 1 0.0709 1.55
GTEx Stomach 0 0.0000 1.58
GTEx Testis 1 0.0317 1.53
GTEx Thyroid 1 0.0250 1.53
GTEx Uterus 0 0.0000 1.73
GTEx Vagina 0 0.0000 1.55
GTEx Whole Blood 0 0.0000 1.50
METSIM Adipose 0 0.0000 1.42
NTR Blood 1 0.0416 1.44
ROSMAP Brain Pre-frontal Cortex 2 0.0455 1.57
YFS Blood 0 0.0000 1.39
CommonMind Brain Pre-frontal Cortex 1 0.0186 1.46
TCGA Breast Tumor 0 0.0000 1.43
TCGA Breast Normal 0 0.0000 1.43
TCGA Ovarian Tumor 0 0.0000 1.39
TCGA Prostate Tumor 0 0.0000 1.46