Hub : Traits :

Average weekly champagne plus white wine intake

11 significantly associated models · 8 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 11 60839578 62326265 5 1 1.1e-08 1.1e-08 1.000 100 TMEM258
2 17 42884538 43913030 2 1 2.7e-07 1.3e-06 1.000 100 LRRC37A4P
3 17 44788310 45597098 1 1 2.4e-07 6.5e-08 0.089 90 WNT3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 5.33 1 0 0.0 0 1 TMEM258
Irritable Bowel Disease (IBD) 3.37 1 0 0.0 0 1 TMEM258
Verbal and Numeric Reasoning (VNR) 7.02 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Breast Cancer 8.13 2 1 3.0 0 1 LRRC37A4P WNT3
Ovarian Cancer 23.17 2 2 6.1 0 1 LRRC37A4P WNT3
Bipolar Disorder 4.61 1 0 0.0 0 1 TMEM258
Crohns Disease (2012) 9.79 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Mean Putamen Volume 7.42 2 0 0.0 0 1 LRRC37A4P WNT3
Fasting Glucose 11.54 1 1 3.0 0 1 TMEM258
HDL Cholesterol 19.82 1 1 3.0 0 1 TMEM258
LDL Cholesterol 22.16 1 1 3.0 0 1 TMEM258
Lupus 5.09 1 0 0.0 0 1 LRRC37A4P
Neuroticism 10.68 2 1 3.0 0 1 LRRC37A4P WNT3
Primary Biliary Cirrhosis 8.37 2 0 0.0 0 1 LRRC37A4P WNT3
Schizophrenia 4.57 2 0 0.0 0 1 LRRC37A4P WNT3
Triglycerides 20.18 1 1 3.0 0 1 TMEM258
Type 2 Diabetes (T2D) 3.25 1 0 0.0 0 1 TMEM258
Blood Eosinophil Count 15.53 3 3 9.1 0 1 LRRC37A4P TMEM258 WNT3
Blood Platelet Count 14.80 3 3 9.1 0 1 LRRC37A4P TMEM258 WNT3
Blood Red Count 40.95 3 3 9.1 0 1 LRRC37A4P TMEM258 WNT3
Blood White Count 5.83 3 2 6.1 0 1 LRRC37A4P TMEM258 WNT3
Heel T-Score 9.75 3 3 9.1 0 1 LRRC37A4P TMEM258 WNT3
Height 4.98 3 3 9.1 0 1 LRRC37A4P TMEM258 WNT3
Waist Hip Ratio (WHR) 13.62 3 2 6.1 0 1 LRRC37A4P TMEM258 WNT3
Systolic Blood Pressure 2.96 2 1 3.0 0 1 LRRC37A4P WNT3
Smoking Status 2.98 1 0 0.0 0 1 LRRC37A4P
Hypothyroidism (self reported) 7.33 1 1 3.0 0 1 TMEM258
Respiratory disease 7.93 1 1 3.0 0 1 TMEM258
Lung FEV1/FVC ratio 2.94 2 0 0.0 0 1 LRRC37A4P WNT3
Lung FVC 26.18 2 2 6.1 0 1 LRRC37A4P WNT3
Neuroticism 25.98 2 2 6.1 0 1 LRRC37A4P WNT3
Hair Pigment 0.87 3 1 3.0 0 1 LRRC37A4P TMEM258 WNT3
Tanning 0.70 2 0 0.0 0 1 LRRC37A4P WNT3
Hand grip strength (left) 10.53 2 2 6.1 0 1 LRRC37A4P WNT3
Number of treatments/medications taken 4.32 1 0 0.0 0 1 TMEM258
Sensitivity / hurt feelings 27.65 2 2 6.1 0 1 LRRC37A4P WNT3
Frequency of depressed mood in last 2 weeks 6.88 2 0 0.0 0 1 LRRC37A4P WNT3
Hearing difficulty/problems: Yes 4.06 1 0 0.0 0 1 LRRC37A4P
Relative age of first facial hair 33.40 2 2 6.1 0 1 LRRC37A4P WNT3
Systolic blood pressure, automated reading 5.40 2 1 3.0 0 1 LRRC37A4P WNT3
Vitamin and mineral supplements 9.52 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Impedance of leg (right) 2.10 2 0 0.0 0 1 LRRC37A4P WNT3
Trunk fat percentage 4.61 2 1 3.0 0 1 LRRC37A4P WNT3
Hand grip strength (right) 8.46 2 2 6.1 0 1 LRRC37A4P WNT3
Townsend deprivation index at recruitment 2.27 1 0 0.0 0 1 TMEM258
Fed-up feelings 14.78 2 2 6.1 0 1 LRRC37A4P WNT3
Relative age voice broke 21.37 2 2 6.1 0 1 LRRC37A4P WNT3
Taking other prescription medications 2.73 1 0 0.0 0 1 TMEM258
Age when periods started (menarche) 3.74 2 0 0.0 0 1 LRRC37A4P WNT3
Heel bone mineral density (BMD) T-score, automated (left) 5.44 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Qualifications: CSEs or equivalent 7.99 2 0 0.0 0 1 LRRC37A4P WNT3
High blood pressure 3.22 2 0 0.0 0 1 LRRC37A4P WNT3
Diverticular disease/diverticulitis (self-reported) 4.77 1 0 0.0 0 1 WNT3
Medication: Levothyroxine sodium 7.44 1 1 3.0 0 1 TMEM258
Sitting height 12.08 3 2 6.1 0 1 LRRC37A4P TMEM258 WNT3
Body mass index (BMI) 0.80 1 0 0.0 0 1 TMEM258
Impedance of leg (left) 2.44 2 0 0.0 0 1 LRRC37A4P WNT3
Trunk fat mass 2.81 2 0 0.0 0 1 LRRC37A4P WNT3
Past tobacco smoking 3.77 1 0 0.0 0 1 LRRC37A4P
Nervous feelings 11.47 2 2 6.1 0 1 LRRC37A4P WNT3
Frequency of tenseness / restlessness in last 2 weeks 17.63 2 2 6.1 0 1 LRRC37A4P WNT3
Hearing difficulty/problems with background noise 7.24 2 0 0.0 0 1 LRRC37A4P WNT3
Hair/balding pattern: Pattern 2 12.65 2 1 3.0 0 1 LRRC37A4P WNT3
Forced vital capacity (FVC) 21.55 2 2 6.1 0 1 LRRC37A4P WNT3
Heel bone mineral density (BMD) T-score, automated (right) 5.93 2 0 0.0 0 1 LRRC37A4P TMEM258
Ever unenthusiastic/disinterested for a whole week 13.89 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Financial difficulties in last 2 years 4.79 1 0 0.0 0 1 WNT3
Mouth/teeth dental problems 4.88 1 0 0.0 0 1 LRRC37A4P
Allergy 2.89 1 0 0.0 0 1 TMEM258
Medication: Simvastatin 3.90 1 0 0.0 0 1 TMEM258
Fluid intelligence score 6.43 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Neuroticism score 22.85 2 2 6.1 0 1 LRRC37A4P WNT3
Impedance of arm (right) 5.13 2 2 6.1 0 1 LRRC37A4P WNT3
Arm fat percentage (right) 1.13 1 0 0.0 0 1 TMEM258
Trunk fat-free mass 0.59 1 0 0.0 0 1 TMEM258
Hip circumference 1.17 1 0 0.0 0 1 LRRC37A4P
Time employed in main current job 8.12 2 0 0.0 0 1 LRRC37A4P WNT3
Worrier / anxious feelings 8.89 2 1 3.0 0 1 LRRC37A4P WNT3
Frequency of tiredness / lethargy in last 2 weeks 3.11 1 0 0.0 0 1 LRRC37A4P
Falls in the last year 4.64 1 0 0.0 0 1 TMEM258
Hair/balding pattern: Pattern 3 36.62 2 2 6.1 0 1 LRRC37A4P WNT3
Number of live births 14.46 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Forced expiratory volume in 1-second (FEV1) 23.09 3 2 6.1 0 1 LRRC37A4P TMEM258 WNT3
Pulse rate 10.14 1 1 3.0 0 1 TMEM258
Noisy workplace 5.85 1 0 0.0 0 1 LRRC37A4P
Qualifications: A levels/AS levels or equivalent 5.68 2 0 0.0 0 1 LRRC37A4P WNT3
Asthma 6.60 1 1 3.0 0 1 TMEM258
Medication: Ibuprofen (e.g. Nurofen) 11.07 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Forced expiratory volume in 1-second (FEV1), Best measure 20.81 2 2 6.1 0 1 LRRC37A4P WNT3
Impedance of arm (left) 6.54 2 2 6.1 0 1 LRRC37A4P WNT3
Standing height 4.11 3 3 9.1 0 1 LRRC37A4P TMEM258 WNT3
Exposure to tobacco smoke at home 3.19 1 0 0.0 0 1 TMEM258
Tense / 'highly strung' 4.16 2 0 0.0 0 1 LRRC37A4P WNT3
Seen doctor (GP) for nerves, anxiety, tension or depression 2.65 1 0 0.0 0 1 TMEM258
Hair/balding pattern: Pattern 4 66.00 3 3 9.1 0 1 LRRC37A4P TMEM258 WNT3
Peak expiratory flow (PEF) 12.80 2 2 6.1 0 1 LRRC37A4P WNT3
Ever highly irritable/argumentative for 2 days 5.03 1 0 0.0 0 1 LRRC37A4P
Blood clot in the leg (DVT) 3.27 1 0 0.0 0 1 TMEM258
Medication: Paracetamol 20.71 2 2 6.1 0 1 LRRC37A4P WNT3
Headache pain in last month 21.69 3 2 6.1 0 1 LRRC37A4P TMEM258 WNT3
Glaucoma (self-reported) 3.56 1 0 0.0 0 1 LRRC37A4P
Hypothyroidism/myxoedema (self-reported) 6.00 1 1 3.0 0 1 TMEM258
High blood pressure (siblings) 4.56 2 0 0.0 0 1 LRRC37A4P WNT3
Forced vital capacity (FVC), Best measure 20.86 2 2 6.1 0 1 LRRC37A4P WNT3
Body fat percentage 2.59 2 0 0.0 0 1 LRRC37A4P WNT3
Leg fat percentage (right) 1.44 1 0 0.0 0 1 TMEM258
Exposure to tobacco smoke outside home 5.60 1 0 0.0 0 1 LRRC37A4P
Comparative body size at age 10 2.19 1 0 0.0 0 1 WNT3
Number of full brothers 5.31 2 0 0.0 0 1 LRRC37A4P WNT3
Worry too long after embarrassment 7.98 2 0 0.0 0 1 LRRC37A4P WNT3
Seen a psychiatrist for nerves, anxiety, tension or depression 4.35 1 0 0.0 0 1 TMEM258
Wheeze or whistling in the chest in last year 5.79 1 0 0.0 0 1 TMEM258
Age at first live birth 4.23 2 0 0.0 0 1 LRRC37A4P WNT3
Qualifications: College or University degree 8.97 2 2 6.1 0 1 LRRC37A4P WNT3
Emphysema/chronic bronchitis 6.24 1 0 0.0 0 1 LRRC37A4P
Medication for pain relief, constipation, heartburn 12.62 3 1 3.0 0 1 LRRC37A4P TMEM258 WNT3
Medication: Ibuprofen 9.91 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Whole body fat mass 1.48 1 0 0.0 0 1 LRRC37A4P
Pulse rate, automated reading 17.72 1 1 3.0 0 1 TMEM258
Alcohol intake frequency. 9.23 2 2 6.1 0 1 LRRC37A4P WNT3
Comparative height size at age 10 4.19 3 1 3.0 0 1 LRRC37A4P TMEM258 WNT3
Suffer from 'nerves' 4.51 1 0 0.0 0 1 LRRC37A4P
Leg pain on walking 5.63 2 0 0.0 0 1 LRRC37A4P WNT3
Qualifications: NVQ or HND or HNC or equivalent 4.37 1 0 0.0 0 1 TMEM258
Commuting to job workplace: Car/motor vehicle 5.07 1 0 0.0 0 1 TMEM258
Supplements: Vitamin C 7.20 2 0 0.0 0 1 LRRC37A4P WNT3
Hypertension (Self-reported) 2.79 2 0 0.0 0 1 LRRC37A4P WNT3
Illnesses of father: Heart disease 4.65 1 0 0.0 0 1 LRRC37A4P
Smoking status: Previous 3.53 1 0 0.0 0 1 LRRC37A4P
Forced expiratory volume in 1-second (FEV1), predicted 2.31 1 0 0.0 0 1 TMEM258
Handedness (chirality/laterality): Left-handed 13.42 2 1 3.0 0 1 LRRC37A4P WNT3
Mood swings 19.94 2 2 6.1 0 1 LRRC37A4P WNT3
Loneliness, isolation 6.93 2 0 0.0 0 1 LRRC37A4P WNT3
Long-standing illness, disability or infirmity 2.81 1 0 0.0 0 1 TMEM258
Ever had bowel cancer screening 4.55 1 0 0.0 0 1 LRRC37A4P
Mouth/teeth dental problems: Mouth ulcers 16.22 2 2 6.1 0 1 LRRC37A4P WNT3
Medication for cholesterol 5.08 2 0 0.0 0 1 LRRC37A4P WNT3
Mineral and other dietary supplements 3.68 1 0 0.0 0 1 TMEM258
Breast cancer (self-reported) 5.03 1 0 0.0 0 1 LRRC37A4P
Asthma (self-reported) 7.24 1 1 3.0 0 1 TMEM258
Osteoporosis (self-reported) 5.33 1 0 0.0 0 1 LRRC37A4P
Forced expiratory volume in 1-second (FEV1), predicted percentage 19.19 2 2 6.1 0 1 LRRC37A4P WNT3
Number of self-reported non-cancer illnesses 2.37 1 0 0.0 0 1 TMEM258
Miserableness 13.97 3 2 6.1 0 1 LRRC37A4P TMEM258 WNT3
Guilty feelings 8.77 2 0 0.0 0 1 LRRC37A4P WNT3
Eye problems/disorders: Glaucoma 4.05 1 0 0.0 0 1 LRRC37A4P
Medication: Blood pressure 6.96 2 0 0.0 0 1 LRRC37A4P WNT3
Supplements: Fish oil (including cod liver oil) 4.71 1 0 0.0 0 1 TMEM258
High cholesterol (Self-reported) 4.13 1 0 0.0 0 1 TMEM258
Medication: Paracetamol 21.02 2 2 6.1 0 1 LRRC37A4P WNT3
Leg fat percentage (left) 1.32 1 0 0.0 0 1 TMEM258
Irritability 16.35 3 2 6.1 0 1 LRRC37A4P TMEM258 WNT3
Fractured/broken bones in last 5 years 7.56 2 0 0.0 0 1 LRRC37A4P WNT3
Diastolic blood pressure, automated reading 3.63 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Ever depressed for a whole week 8.42 2 0 0.0 0 1 LRRC37A4P WNT3
Myopia 9.53 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Vascular/heart problems diagnosed by doctor 2.33 1 0 0.0 0 1 LRRC37A4P
Cholesterol lowering medication 3.43 1 0 0.0 0 1 TMEM258
Pain experienced in last month 4.29 1 0 0.0 0 1 LRRC37A4P
Heart attack/myocardial infarction (self-reported) 2.25 1 0 0.0 0 1 TMEM258
Deep venous thrombosis (DVT) (self-reported) 3.00 1 0 0.0 0 1 TMEM258
Heart disease (siblings) 6.10 2 0 0.0 0 1 LRRC37A4P WNT3
Impedance of whole body 5.60 2 2 6.1 0 1 LRRC37A4P WNT3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.35
GTEx Adipose Visceral Omentum 0 0.0000 1.42
GTEx Adrenal Gland 0 0.0000 1.51
GTEx Artery Aorta 0 0.0000 1.47
GTEx Artery Coronary 1 0.0845 1.49
GTEx Artery Tibial 1 0.0266 1.38
GTEx Brain Caudate basal ganglia 0 0.0000 1.45
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.41
GTEx Brain Cerebellum 0 0.0000 1.43
GTEx Brain Cortex 0 0.0000 1.50
GTEx Brain Frontal Cortex BA9 0 0.0000 1.48
GTEx Brain Hippocampus 0 0.0000 1.51
GTEx Brain Hypothalamus 0 0.0000 1.46
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.47
GTEx Brain Putamen basal ganglia 0 0.0000 1.69
GTEx Breast Mammary Tissue 0 0.0000 1.48
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.42
GTEx Breast Mammary Tissue (Female) 1 0.0608 1.50
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.47
GTEx Cells Transformed fibroblasts 0 0.0000 1.36
GTEx Colon Sigmoid 0 0.0000 1.39
GTEx Colon Transverse 0 0.0000 1.47
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.53
GTEx Esophagus Mucosa 0 0.0000 1.40
GTEx Esophagus Muscularis 0 0.0000 1.41
GTEx Heart Atrial Appendage 1 0.0633 1.42
GTEx Heart Left Ventricle 0 0.0000 1.49
GTEx Liver 0 0.0000 1.42
GTEx Lung 0 0.0000 1.43
GTEx Muscle Skeletal 1 0.0346 1.37
GTEx Nerve Tibial 0 0.0000 1.34
GTEx Ovary 0 0.0000 1.50
GTEx Pancreas 0 0.0000 1.45
GTEx Pituitary 0 0.0000 1.40
GTEx Prostate 0 0.0000 1.41
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.34
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.37
GTEx Small Intestine Terminal Ileum 0 0.0000 1.48
GTEx Spleen 0 0.0000 1.41
GTEx Stomach 0 0.0000 1.40
GTEx Testis 0 0.0000 1.48
GTEx Thyroid 0 0.0000 1.39
GTEx Uterus 0 0.0000 1.52
GTEx Vagina 0 0.0000 1.65
GTEx Whole Blood 0 0.0000 1.43
METSIM Adipose 0 0.0000 1.30
NTR Blood 1 0.0416 1.28
ROSMAP Brain Pre-frontal Cortex 2 0.0455 1.38
YFS Blood 0 0.0000 1.32
CommonMind Brain Pre-frontal Cortex 2 0.0372 1.33
TCGA Breast Tumor 0 0.0000 1.38
TCGA Breast Normal 1 0.0238 1.31
TCGA Ovarian Tumor 0 0.0000 1.30
TCGA Prostate Tumor 0 0.0000 1.38