Hub : Traits :

Pulse rate

298 significantly associated models · 89 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 66527848 67938108 1 1 3.2e-07 3.1e-08 7.7e-03 77 TCTEX1D1
2 1 86760937 88329338 1 1 3.0e-07 1.3e-09 1.6e-07 26 LOC339524
3 2 178362572 179939959 1 1 6.3e-10 6.3e-41 5.0e-34 18 OSBPL6
4 2 231564626 232955363 1 1 1.2e-07 1.1e-08 2.8e-02 85 B3GNT7
5 3 48012797 51043528 22 1 1.0e-09 2.0e-08 6.1e-03 76 TRAIP
6 3 52565100 53985919 1 1 1.4e-07 9.2e-08 6.8e-03 74 TKT
7 3 140350567 141867638 1 1 6.7e-08 1.8e-08 1.0e+00 100 ZBTB38
8 5 136386984 138474788 4 2 7.8e-11 7.8e-11 1.0e+00 100 REEP2 RP11-381K20.5
9 6 118089396 119949791 2 1 1.8e-19 2.9e-25 8.9e-08 74 MCM9
10 6 120704438 122457698 2 4 1.0e-20 5.4e-38 3.6e-07 84 GJA1 TBC1D32
11 7 99060603 101185166 13 1 1.2e-28 8.2e-26 1.2e-01 98 GIGYF1
12 9 35213538 36597142 1 1 3.2e-09 6.7e-09 1.0e+00 100 LINC00961
13 11 13288698 14975818 1 1 1.3e-07 6.7e-08 1.3e-01 92 SPON1
14 11 60839578 62346131 6 1 2.2e-13 1.1e-13 1.0e+00 100 FADS1
15 12 32851364 34826574 2 2 4.3e-13 4.5e-24 6.9e-11 58 ALG10
16 12 38353816 39998144 1 1 9.1e-08 1.0e-07 1.9e-01 94 CPNE8
17 13 41092698 42640341 2 1 3.2e-09 9.0e-07 7.0e-01 99 NAA16
18 14 20843889 22255090 1 1 1.2e-08 1.9e-15 1.2e-09 41 ARHGEF40
19 14 22670975 24728294 6 5 2.3e-24 1.5e-61 7.5e-23 65 HOMEZ PPP1R3E RBM23 RP11-66N24.4 SLC22A17
20 14 85303548 86791228 1 1 8.1e-23 1.8e-22 1.0e+00 100 FLRT2
21 15 72287856 74291976 2 3 1.7e-10 3.5e-19 7.5e-12 42 BBS4 NEO1
22 17 14714000 16109675 1 1 1.2e-07 8.1e-07 3.1e-06 11 AC005517.3
23 19 38444944 39931031 2 2 4.5e-09 1.9e-09 6.6e-02 91 ACTN4 CAPN12
24 20 35835657 37586842 2 2 1.2e-22 3.7e-51 2.2e-28 46 KIAA1755 VSTM2L
25 22 38192452 40111623 10 1 2.6e-08 4.4e-08 1.0e+00 100 RP3-508I15.9

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 1.49 3 1 3.0 0.00 1.0e+00 FADS1 GIGYF1 ZBTB38
Irritable Bowel Disease (IBD) 1.06 3 1 3.0 0.00 1.0e+00 FADS1 GIGYF1 TCTEX1D1
Ulcerative Colitis (UC) 0.86 1 0 0.0 0.00 1.0e+00 TCTEX1D1
Reaction Time 1.18 1 0 0.0 0.00 1.0e+00 CPNE8
Verbal and Numeric Reasoning (VNR) 0.96 2 1 3.0 0.00 1.0e+00 FADS1 TKT
Breast Cancer 1.30 1 1 3.0 0.00 1.0e+00 ZBTB38
Crohns Disease (2012) 1.58 1 0 0.0 0.00 1.0e+00 FADS1
Fasting Glucose 2.00 1 1 3.0 0.00 1.0e+00 FADS1
HDL Cholesterol 2.44 1 1 3.0 0.00 1.0e+00 FADS1
LDL Cholesterol 2.08 1 1 3.0 0.00 1.0e+00 FADS1
Schizophrenia 1.52 2 0 0.0 0.00 1.0e+00 GIGYF1 TKT
Triglycerides 2.91 3 1 3.0 0.00 1.0e+00 BBS4 FADS1 NEO1
Ulcerative Colitis 1.05 1 0 0.0 0.00 1.0e+00 TCTEX1D1
Blood Eosinophil Count 1.00 3 2 6.1 0.00 1.0e+00 FADS1 SLC22A17 TRAIP
Blood Platelet Count 1.81 5 3 9.1 -0.21 7.4e-01 ACTN4 CAPN12 FADS1 RP3-508I15.9 VSTM2L
Blood Red Count 2.43 8 7 21.2 -0.84 9.0e-03 BBS4 FADS1 GIGYF1 GJA1 NAA16 TKT TRAIP ZBTB38
Blood White Count 1.07 4 2 6.1 0.65 3.5e-01 ACTN4 FADS1 NAA16 TCTEX1D1
Heel T-Score 2.18 7 7 21.2 -0.16 7.1e-01 FADS1 GIGYF1 GJA1 RP3-508I15.9 TCTEX1D1 TRAIP ZBTB38
BMI 0.63 2 2 6.1 0.00 1.0e+00 BBS4 NEO1
Height 4.10 12 4 12.1 -0.01 9.7e-01 ALG10 ARHGEF40 B3GNT7 BBS4 FADS1 GIGYF1 RP3-508I15.9 SPON1 TBC1D32 TCTEX1D1 TKT ZBTB38
Waist Hip Ratio (WHR) 1.99 6 3 9.1 0.34 4.5e-01 ALG10 REEP2 SLC22A17 TKT TRAIP ZBTB38
Systolic Blood Pressure 1.21 3 1 3.0 0.00 1.0e+00 HOMEZ NAA16 SLC22A17
Smoking Status 0.93 1 0 0.0 0.00 1.0e+00 TRAIP
Allergy or Eczema 1.23 1 1 3.0 0.00 1.0e+00 ZBTB38
Cardiovascular Disease 0.75 1 0 0.0 0.00 1.0e+00 NAA16
Hypothyroidism (self reported) 1.54 2 1 3.0 0.00 1.0e+00 FADS1 GIGYF1
Respiratory disease 1.39 2 1 3.0 0.00 1.0e+00 FADS1 GJA1
Type 2 Diabetes (T2D) 1.39 1 0 0.0 0.00 1.0e+00 TRAIP
Lung FEV1/FVC ratio 1.63 6 2 6.1 -0.38 3.9e-01 ACTN4 GJA1 NEO1 PPP1R3E SLC22A17 ZBTB38
Lung FVC 0.93 2 1 3.0 0.00 1.0e+00 B3GNT7 ZBTB38
Neuroticism 1.14 2 0 0.0 0.00 1.0e+00 RP11-381K20.5 SLC22A17
Chronotype (morning person) 2.41 2 2 6.1 0.00 1.0e+00 ALG10 CPNE8
Hair Pigment 0.65 4 2 6.1 -0.08 9.2e-01 FADS1 GIGYF1 REEP2 ZBTB38
Tanning 0.15 1 0 0.0 0.00 1.0e+00 TCTEX1D1
Hand grip strength (left) 1.45 2 1 3.0 0.00 1.0e+00 ARHGEF40 ZBTB38
Number of treatments/medications taken 1.17 1 0 0.0 0.00 1.0e+00 FADS1
Relative age of first facial hair 1.33 1 0 0.0 0.00 1.0e+00 ZBTB38
Ever used hormone-replacement therapy (HRT) 0.85 1 0 0.0 0.00 1.0e+00 RP3-508I15.9
Systolic blood pressure, automated reading 1.53 4 1 3.0 -0.69 3.1e-01 HOMEZ NAA16 RBM23 SLC22A17
Severe depression (siblings) 1.17 1 0 0.0 0.00 1.0e+00 NEO1
Impedance of leg (right) 0.67 2 0 0.0 0.00 1.0e+00 ARHGEF40 VSTM2L
Leg fat-free mass (left) 2.08 3 2 6.1 0.00 1.0e+00 ARHGEF40 VSTM2L ZBTB38
Trunk fat percentage 1.61 4 3 9.1 0.98 3.3e-03 BBS4 NEO1 TRAIP ZBTB38
Hand grip strength (right) 1.32 3 1 3.0 0.00 1.0e+00 ARHGEF40 GIGYF1 ZBTB38
Relative age voice broke 0.78 1 0 0.0 0.00 1.0e+00 TRAIP
Heel bone mineral density (BMD) T-score, automated (left) 1.75 3 1 3.0 0.00 1.0e+00 FADS1 RP3-508I15.9 TRAIP
Hayfever, allergic rhinitis or eczema 1.11 1 1 3.0 0.00 1.0e+00 ZBTB38
Medication: Levothyroxine sodium 1.35 2 1 3.0 0.00 1.0e+00 FADS1 GIGYF1
Sitting height 3.08 5 2 6.1 -0.08 9.0e-01 ARHGEF40 FADS1 KIAA1755 VSTM2L ZBTB38
Body mass index (BMI) 0.63 1 0 0.0 0.00 1.0e+00 BBS4
Impedance of leg (left) 0.72 2 1 3.0 0.00 1.0e+00 ARHGEF40 VSTM2L
Leg predicted mass (left) 2.09 3 2 6.1 0.00 1.0e+00 ARHGEF40 VSTM2L ZBTB38
Trunk fat mass 1.77 4 3 9.1 0.92 8.4e-02 BBS4 NEO1 TRAIP ZBTB38
Waist circumference 1.36 3 2 6.1 0.99 5.2e-03 BBS4 NEO1 ZBTB38
Nervous feelings 1.16 1 0 0.0 0.00 1.0e+00 FLRT2
Frequency of tenseness / restlessness in last 2 weeks 1.57 1 0 0.0 0.00 1.0e+00 TKT
Forced vital capacity (FVC) 1.49 2 1 3.0 0.00 1.0e+00 BBS4 ZBTB38
Heel bone mineral density (BMD) T-score, automated (right) 2.21 5 1 3.0 0.33 5.9e-01 ALG10 FADS1 RP3-508I15.9 TRAIP ZBTB38
Allergy 1.33 2 1 3.0 0.00 1.0e+00 FADS1 ZBTB38
Medication: Simvastatin 1.13 1 0 0.0 0.00 1.0e+00 FADS1
Fluid intelligence score 1.13 1 0 0.0 0.00 1.0e+00 TKT
Neuroticism score 1.21 1 0 0.0 0.00 1.0e+00 SLC22A17
Weight 1.87 1 1 3.0 0.00 1.0e+00 ZBTB38
Impedance of arm (right) 0.72 1 0 0.0 0.00 1.0e+00 REEP2
Arm fat percentage (right) 1.15 2 1 3.0 0.00 1.0e+00 BBS4 NEO1
Trunk fat-free mass 2.57 4 3 9.1 -0.47 5.3e-01 ARHGEF40 B3GNT7 PPP1R3E ZBTB38
Hip circumference 1.36 2 2 6.1 0.00 1.0e+00 RP3-508I15.9 ZBTB38
Frequency of tiredness / lethargy in last 2 weeks 1.26 1 0 0.0 0.00 1.0e+00 TRAIP
Number of live births 1.19 1 1 3.0 0.00 1.0e+00 FADS1
Forced expiratory volume in 1-second (FEV1) 1.24 2 1 3.0 0.00 1.0e+00 PPP1R3E ZBTB38
Serious illness, injury or assault of a close relative in last 2 years 1.51 1 0 0.0 0.00 1.0e+00 NEO1
Mouth/teeth dental problems: Dentures 0.81 1 0 0.0 0.00 1.0e+00 BBS4
Asthma 1.31 3 1 3.0 0.00 1.0e+00 FADS1 GJA1 ZBTB38
Forced expiratory volume in 1-second (FEV1), Best measure 1.31 3 1 3.0 -0.68 3.2e-01 GJA1 PPP1R3E ZBTB38
Impedance of arm (left) 0.82 2 0 0.0 0.00 1.0e+00 PPP1R3E REEP2
Arm fat mass (right) 1.11 3 2 6.1 0.00 1.0e+00 BBS4 NEO1 ZBTB38
Trunk predicted mass 2.57 4 3 9.1 -0.47 5.3e-01 ARHGEF40 B3GNT7 PPP1R3E ZBTB38
Standing height 3.83 4 4 12.1 0.10 9.0e-01 ARHGEF40 B3GNT7 FADS1 ZBTB38
Seen doctor (GP) for nerves, anxiety, tension or depression 1.61 1 0 0.0 0.00 1.0e+00 TKT
Hair/balding pattern: Pattern 4 1.80 2 2 6.1 0.00 1.0e+00 FADS1 ZBTB38
Birth weight of first child 1.38 1 1 3.0 0.00 1.0e+00 ZBTB38
Peak expiratory flow (PEF) 1.09 1 0 0.0 0.00 1.0e+00 PPP1R3E
Pulse wave reflection index 5.82 5 1 3.0 -1.00 1.8e-04 HOMEZ KIAA1755 PPP1R3E TBC1D32 VSTM2L
Blood clot in the leg (DVT) 1.32 1 0 0.0 0.00 1.0e+00 FADS1
Headache pain in last month 1.39 2 0 0.0 0.00 1.0e+00 BBS4 TBC1D32
Gout (self-reported) 1.37 1 0 0.0 0.00 1.0e+00 TKT
Hypothyroidism/myxoedema (self-reported) 1.45 2 0 0.0 0.00 1.0e+00 FADS1 GIGYF1
Birth weight 1.50 1 0 0.0 0.00 1.0e+00 ARHGEF40
Forced vital capacity (FVC), Best measure 1.58 3 1 3.0 0.00 1.0e+00 BBS4 SPON1 ZBTB38
Body fat percentage 1.42 4 2 6.1 0.99 8.0e-04 BBS4 NEO1 TRAIP ZBTB38
Leg fat percentage (right) 1.27 2 2 6.1 0.00 1.0e+00 BBS4 NEO1
Arm fat-free mass (right) 2.23 5 2 6.1 -0.14 8.2e-01 ARHGEF40 B3GNT7 PPP1R3E VSTM2L ZBTB38
Seen a psychiatrist for nerves, anxiety, tension or depression 1.57 1 0 0.0 0.00 1.0e+00 FADS1
Wheeze or whistling in the chest in last year 1.02 1 0 0.0 0.00 1.0e+00 FADS1
Age at first live birth 1.52 1 0 0.0 0.00 1.0e+00 NEO1
Qualifications: College or University degree 0.84 1 0 0.0 0.00 1.0e+00 NEO1
Migraine (self-reported) 0.90 1 0 0.0 0.00 1.0e+00 TBC1D32
Medication: Seretide 50 evohaler 1.68 1 0 0.0 0.00 1.0e+00 GJA1
Whole body fat mass 1.46 4 2 6.1 0.93 7.4e-02 BBS4 NEO1 TRAIP ZBTB38
Leg fat mass (right) 1.23 3 2 6.1 0.99 6.0e-03 BBS4 NEO1 ZBTB38
Arm predicted mass (right) 2.19 4 2 6.1 -0.51 4.9e-01 ARHGEF40 B3GNT7 PPP1R3E ZBTB38
Pulse rate, automated reading 39.34 34 34 103.0 0.99 7.5e-33 AC005517.3 ACTN4 ALG10 ARHGEF40 B3GNT7 BBS4 CAPN12 CPNE8 FADS1 FLRT2 GIGYF1 GJA1 HOMEZ KIAA1755 LINC00961 LOC339524 MCM9 NAA16 NEO1 OSBPL6 PPP1R3E RBM23 REEP2 RP11-381K20.5 RP11-66N24.4 RP3-508I15.9 SLC22A17 SPON1 TBC1D32 TCTEX1D1 TKT TRAIP VSTM2L ZBTB38
Alcohol intake frequency. 1.27 1 0 0.0 0.00 1.0e+00 RP3-508I15.9
Comparative height size at age 10 3.22 4 3 9.1 0.40 6.0e-01 ALG10 ARHGEF40 B3GNT7 ZBTB38
Overall health rating 1.59 1 0 0.0 0.00 1.0e+00 RP3-508I15.9
Age at last live birth 1.11 1 0 0.0 0.00 1.0e+00 TBC1D32
Forced expiratory volume in 1-second (FEV1), predicted 2.47 1 1 3.0 0.00 1.0e+00 ZBTB38
Whole body fat-free mass 2.38 4 2 6.1 0.07 9.3e-01 ARHGEF40 B3GNT7 VSTM2L ZBTB38
Leg fat-free mass (right) 2.06 3 2 6.1 0.00 1.0e+00 ARHGEF40 VSTM2L ZBTB38
Arm fat percentage (left) 1.21 2 2 6.1 0.00 1.0e+00 BBS4 NEO1
Average weekly red wine intake 1.39 1 0 0.0 0.00 1.0e+00 NEO1
Asthma (self-reported) 1.43 3 1 3.0 0.00 1.0e+00 FADS1 GJA1 ZBTB38
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.37 1 0 0.0 0.00 1.0e+00 GJA1
Whole body water mass 2.35 4 2 6.1 0.07 9.3e-01 ARHGEF40 B3GNT7 VSTM2L ZBTB38
Leg predicted mass (right) 2.08 3 2 6.1 0.00 1.0e+00 ARHGEF40 VSTM2L ZBTB38
Arm fat mass (left) 1.18 3 2 6.1 0.00 1.0e+00 BBS4 NEO1 ZBTB38
Average weekly champagne plus white wine intake 1.51 1 1 3.0 0.00 1.0e+00 FADS1
Supplements: Fish oil (including cod liver oil) 1.53 1 0 0.0 0.00 1.0e+00 FADS1
High cholesterol (Self-reported) 0.96 1 0 0.0 0.00 1.0e+00 FADS1
Ever smoked 1.24 1 0 0.0 0.00 1.0e+00 TRAIP
Basal metabolic rate 2.27 3 2 6.1 0.00 1.0e+00 ARHGEF40 B3GNT7 ZBTB38
Leg fat percentage (left) 1.31 2 2 6.1 0.00 1.0e+00 BBS4 NEO1
Arm fat-free mass (left) 2.25 4 1 3.0 -0.51 4.9e-01 ARHGEF40 B3GNT7 PPP1R3E ZBTB38
Irritability 1.79 1 0 0.0 0.00 1.0e+00 FADS1
Ever had prostate specific antigen (PSA) test 1.33 1 0 0.0 0.00 1.0e+00 ZBTB38
Diastolic blood pressure, automated reading 2.88 6 2 6.1 0.99 2.2e-04 AC005517.3 GIGYF1 LOC339524 SPON1 TKT TRAIP
Deep venous thrombosis (DVT) (self-reported) 1.22 1 0 0.0 0.00 1.0e+00 FADS1
Impedance of whole body 0.74 1 0 0.0 0.00 1.0e+00 TRAIP
Leg fat mass (left) 1.21 3 2 6.1 1.00 4.9e-03 BBS4 NEO1 ZBTB38
Arm predicted mass (left) 2.21 4 1 3.0 -0.52 4.8e-01 ARHGEF40 B3GNT7 PPP1R3E ZBTB38

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 9 0.2578 1.68
GTEx Adipose Visceral Omentum 5 0.2456 1.71
GTEx Adrenal Gland 1 0.0686 1.73
GTEx Artery Aorta 9 0.3023 1.77
GTEx Artery Coronary 4 0.3381 1.78
GTEx Artery Tibial 11 0.2925 1.75
GTEx Brain Caudate basal ganglia 1 0.1087 1.59
GTEx Brain Cerebellar Hemisphere 3 0.2015 1.71
GTEx Brain Cerebellum 4 0.2018 1.68
GTEx Brain Cortex 1 0.0966 1.56
GTEx Brain Frontal Cortex BA9 0 0.0000 1.59
GTEx Brain Hippocampus 0 0.0000 1.52
GTEx Brain Hypothalamus 1 0.1695 1.63
GTEx Brain Nucleus accumbens basal ganglia 3 0.3468 1.63
GTEx Brain Putamen basal ganglia 5 0.8013 2.00
GTEx Breast Mammary Tissue 5 0.2533 1.64
GTEx Breast Mammary Tissue (Male) 1 0.0838 1.48
GTEx Breast Mammary Tissue (Female) 6 0.3650 1.73
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.58
GTEx Cells Transformed fibroblasts 10 0.2382 1.70
GTEx Colon Sigmoid 2 0.1368 1.66
GTEx Colon Transverse 8 0.3876 1.75
GTEx Esophagus Gastroesophageal Junction 5 0.3460 1.83
GTEx Esophagus Mucosa 14 0.4217 1.79
GTEx Esophagus Muscularis 6 0.1856 1.70
GTEx Heart Atrial Appendage 8 0.5066 2.07
GTEx Heart Left Ventricle 6 0.3922 1.93
GTEx Liver 2 0.2789 1.80
GTEx Lung 6 0.2088 1.74
GTEx Muscle Skeletal 9 0.3114 1.77
GTEx Nerve Tibial 19 0.4397 1.84
GTEx Ovary 4 0.4405 2.03
GTEx Pancreas 3 0.1838 1.72
GTEx Pituitary 5 0.4484 1.84
GTEx Prostate 2 0.2395 1.67
GTEx Skin Not Sun Exposed Suprapubic 10 0.4067 1.87
GTEx Skin Sun Exposed Lower leg 16 0.4396 1.75
GTEx Small Intestine Terminal Ileum 1 0.2169 1.65
GTEx Spleen 3 0.2126 1.72
GTEx Stomach 5 0.3439 1.74
GTEx Testis 11 0.3487 1.73
GTEx Thyroid 10 0.2501 1.74
GTEx Uterus 3 0.5291 1.68
GTEx Vagina 3 0.4724 1.75
GTEx Whole Blood 6 0.3011 1.63
METSIM Adipose 10 0.2169 1.62
NTR Blood 4 0.1665 1.69
ROSMAP Brain Pre-frontal Cortex 13 0.2961 1.71
YFS Blood 4 0.0866 1.63
CommonMind Brain Pre-frontal Cortex 11 0.2047 1.62
TCGA Breast Tumor 0 0.0000 1.54
TCGA Breast Normal 5 0.1188 1.56
TCGA Ovarian Tumor 2 0.0684 1.44
TCGA Prostate Tumor 3 0.0867 1.63