TWAS hub - LOC158376

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0670	0.0290	8.4e-03	-0.002	0.024	0.003	0.03	-0.002	6.0e-01	5.3e-04	1.2e-01	0.00013	6.2e-01
2	TCGA	Breast Invasive Carcinoma	0.0279	0.0148	3.2e-03	0.006	0.014	0.012	NA	0.009	1.7e-02	4.7e-04	1.3e-03	NA	4.6e-03
3	TCGA	Brain Lower Grade Glioma	0.1227	0.0371	1.1e-08	0.040	0.074	0.062	NA	0.059	2.1e-05	9.7e-09	1.6e-07	NA	2.5e-07
4	TCGA	Prostate Adenocarcinoma	0.0863	0.0322	1.4e-05	0.057	0.061	0.054	NA	0.077	1.4e-06	5.8e-07	2.3e-06	NA	1.9e-08
5	TCGA	Stomach Adenocarcinoma	0.0870	0.0450	8.5e-03	-0.004	0.005	0.014	NA	-0.003	7.9e-01	1.3e-01	3.2e-02	NA	7.2e-01
6	TCGA	Thyroid Carcinoma	0.1270	0.0410	2.5e-07	0.092	0.071	0.059	NA	0.078	2.7e-09	1.8e-07	2.0e-06	NA	4.5e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Pulse rate	9.4	15.9	36.5	0.6	2.6	5.1	4.8	1.7	6.0
Medication: Seretide 50 evohaler	8.7	10.0	21.3	1.9	-0.9	4.5	4.6	1.8	3.2
Pulse rate, automated reading	8.2	26.5	61.8	1.3	4.2	5.0	6.8	2.5	7.9
Pulse wave reflection index	5.6	6.9	12.3	0.4	-3.1	-2.5	-2.7	-2.3	-3.5
Supplements: Calcium	5.3	5.8	10.7	-0.8	-2.5	-2.2	-2.5	-2.5	-3.3
Had other major operations	4.8	5.9	10.2	0.6	-2.2	-2.4	-2.6	-3.2	-2.8
Average weekly fortified wine intake	4.3	5.0	9.3	-0.5	-0.5	-3.1	-2.7	-2.0	-3.0
High blood pressure (siblings)	3.6	5.1	13.0	-1.0	-0.8	-3.6	-2.8	-1.7	-2.3
Ulcerative Colitis	3.4	4.9	9.8	-1.4	-1.2	-2.7	-2.9	-0.7	-3.1
Bilateral oophorectomy (both ovaries removed)	3.0	3.5	7.7	1.0	2.0	2.8	1.4	1.8	1.6
Fractured/broken bones in last 5 years	3.0	3.9	9.4	1.3	-1.7	-1.9	-1.7	-3.1	-1.8
Pulse wave Arterial Stiffness index	2.6	3.0	8.2	0.5	-1.2	-1.1	-1.8	-2.9	-1.9
Age at first live birth	2.4	4.3	7.7	-2.6	-2.6	-1.3	-0.4	-2.8	-1.5
Worry (Nagel 2018)	2.3	4.8	9.0	-2.0	-0.6	-2.6	-3.0	-1.9	-2.2
Serious illness, injury or assault to yourself	2.3	2.8	5.4	-1.6	0.4	-2.3	-2.1	-1.7	-1.1
Pulse wave peak to peak time	2.2	2.6	7.0	-0.6	1.1	1.1	1.6	2.6	1.8
Diabetes (mother)	2.1	2.6	5.3	1.2	2.3	1.2	0.8	2.2	1.4
Eye problems/disorders: Cataract	2.1	2.4	5.9	-1.0	-1.1	-2.4	-1.5	-1.1	-1.7
Guilty feelings	2.1	3.1	8.2	-2.9	-1.0	-1.5	-1.1	-1.9	-1.7
Neuroticism (2016)	2.0	2.9	10.1	-2.4	3.2	-0.1	0.0	0.9	0.7
Average weekly spirits intake	2.0	2.4	7.8	-0.8	-2.8	-1.1	-0.9	-1.7	-1.1
Alcohol intake versus 10 years previously	2.0	2.9	7.1	0.5	2.6	0.8	0.6	2.7	1.5
Number of full sisters	2.0	2.4	5.2	1.4	2.3	2.0	0.9	1.4	0.8
Systolic Blood Pressure	1.9	9.3	24.7	-1.6	-1.6	-5.0	-2.8	-3.4	-2.6
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.3	4.9	1.7	0.7	1.7	0.7	2.2	1.4
Ever had bowel cancer screening	1.9	2.2	10.8	3.3	0.1	0.8	0.4	-1.2	0.1
Ever taken oral contraceptive pill	1.9	2.1	4.7	0.0	2.2	1.5	0.9	1.8	1.3
Illnesses of father: High blood pressure	1.9	2.3	7.7	-1.0	1.4	-2.8	-1.5	0.7	-0.7
Ever smoked	1.9	3.4	8.7	-3.0	-1.3	-2.2	-1.0	-1.7	-1.1
Ever had hysterectomy (womb removed)	1.8	2.0	3.6	-0.0	1.9	1.6	1.4	0.8	1.9
Chronic bronchitis/emphysema (father)	1.8	2.1	4.9	1.6	0.8	0.4	2.0	0.8	2.2
Pack years of smoking	1.8	2.7	6.4	2.5	-0.2	1.4	1.9	1.5	1.4
Frequency of depressed mood in last 2 weeks	1.7	2.3	5.1	-2.1	2.3	-1.4	0.2	0.7	1.3
Depression (self-reported)	1.7	2.0	7.2	-1.2	2.7	-1.4	-0.9	-0.6	0.5
Medication: Bendroflumethiazide	1.7	2.6	7.9	-0.3	-0.9	-2.8	-1.6	-1.6	-1.2
Alzheimer’s Disease (in mother)	1.6	1.9	5.0	0.0	2.2	0.9	0.8	1.3	1.8
Triglycerides	1.6	2.6	13.7	3.7	-0.3	0.8	-0.9	0.2	-0.7
Pack years adult smoking proportion	1.6	2.5	6.0	2.5	-0.6	1.4	1.7	1.4	1.3
Nervous feelings	1.6	3.0	5.5	-2.1	0.3	-2.3	-1.7	-1.8	-1.5
Had menopause	1.6	2.0	6.8	-0.5	-1.2	-1.7	-0.5	-2.6	-0.6
Glaucoma (self-reported)	1.6	1.9	3.7	1.9	-1.0	1.6	0.5	1.9	0.5
Medication: Amlodipine	1.6	2.2	7.4	-2.0	-0.4	-2.7	-1.1	-0.0	-0.9
Sensitivity / hurt feelings	1.5	2.5	8.9	-3.0	-1.7	-0.4	-0.4	-1.7	-0.3
Fed-up feelings	1.5	2.7	5.4	-2.3	0.7	-2.0	-2.1	0.4	-1.4
Fasting Glucose	1.4	1.7	3.8	-0.2	-0.7	-1.9	-1.6	-0.7	-1.7
Hand grip strength (right)	1.4	3.9	8.1	-0.8	-2.5	-1.1	-1.9	-1.9	-2.9
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	8.1	-0.6	2.8	-0.6	-0.1	-0.2	0.6
Birth weight	1.4	3.1	7.7	-0.9	0.8	2.8	2.1	1.5	1.7
Irritability	1.4	2.4	9.1	-3.0	0.1	-0.6	-1.1	-1.8	-0.7
Age at First Birth	1.3	1.9	8.0	-2.8	-1.3	-1.1	-0.5	-0.2	-0.2
Chronotype (morning person)	1.3	2.9	6.7	2.6	0.8	2.4	-0.0	2.0	0.2
Taking other prescription medications	1.3	2.0	4.3	0.7	2.0	0.9	1.4	-0.0	2.1
High blood pressure	1.3	3.7	18.6	-0.9	-0.4	-4.3	-1.1	-1.1	-0.4
Neuroticism score	1.3	2.8	11.0	-3.3	0.6	-1.6	-1.1	-1.2	-0.4
Arm fat percentage (right)	1.3	5.0	11.8	1.7	2.3	1.6	1.4	3.4	2.3
Number of live births	1.3	1.8	6.9	2.6	-0.5	1.2	1.3	-0.8	0.4
Asthma	1.3	2.5	5.2	2.3	-0.6	1.2	1.9	-0.6	2.1
Exposure to tobacco smoke at home	1.3	1.4	2.9	-0.8	-1.7	-1.4	0.0	-1.7	-0.5
Asthma (self-reported)	1.3	2.6	5.4	2.3	-0.5	1.4	1.8	-0.7	2.1
Waist Hip Ratio (WHR)	1.2	5.5	10.7	0.1	-2.5	-2.3	-2.1	-3.3	-2.5
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	5.8	-0.4	0.1	-2.4	-0.7	-1.4	-0.7
Alcohol usually taken with meals	1.2	2.0	5.0	-0.4	-0.5	-2.2	-1.8	-0.5	-1.7
Loud music exposure frequency	1.2	1.3	3.7	-1.9	-0.4	-0.9	-1.1	0.5	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	2.9	0.5	-0.5	0.1	1.6	1.6	1.7
Suffer from ‘nerves’	1.2	1.9	4.7	-1.1	0.7	-2.2	-1.7	-0.7	-1.2
Arm fat percentage (left)	1.2	4.9	11.8	1.4	2.2	1.8	1.4	3.4	2.3
Average weekly red wine intake	1.2	1.8	4.5	-2.1	-0.8	-1.7	-1.0	-0.8	-1.0
Back pain experienced in last month	1.2	1.8	5.5	0.4	0.1	-1.5	-2.3	0.1	-1.7
Mother’s age at death	1.2	1.5	3.9	2.0	-0.7	0.0	1.7	-0.3	1.3
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.1	-1.3	-0.6	-1.8	-0.7	-1.6	-0.9
Commuting to job workplace: Cycle	1.2	1.4	2.8	-1.5	0.8	-1.3	-1.1	-1.7	-0.3
Bipolar Disorder (2018)	1.1	1.8	5.2	-2.3	-1.2	-1.2	-0.9	-0.6	-1.2
Neuroticism (Nagel 2018)	1.1	2.7	7.2	-2.7	0.1	-1.9	-1.7	-1.0	-1.0
Crohns Disease (2017)	1.1	2.3	6.6	1.0	2.2	0.7	0.8	2.6	0.6
Cardiovascular Disease	1.1	3.5	15.8	-1.7	-0.1	-4.0	-1.0	-1.2	-0.2
Neuroticism	1.1	2.6	9.1	-3.0	0.4	-1.8	-1.2	-1.1	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	7.1	0.3	2.7	-0.7	0.0	0.7	0.8
Time employed in main current job	1.1	1.3	5.1	-2.3	-0.9	-1.1	-0.3	-0.5	-0.4
Falls in the last year	1.1	1.5	2.2	-1.4	0.8	-1.4	-1.5	-0.6	-1.4
Prospective memory result	1.1	1.3	2.1	-0.2	-0.5	-1.3	-1.4	-1.4	-1.4
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	2.3	-1.4	0.8	-1.5	-1.5	-1.2	-1.5
Blood clot in the leg (DVT)	1.1	1.4	4.2	0.1	-0.6	-1.5	-1.0	-2.0	-0.8
Age at last live birth	1.1	1.5	4.8	-2.2	-1.4	0.5	1.3	-0.7	0.2
Hypertension (Self-reported)	1.1	3.2	16.6	-0.8	-0.2	-4.1	-0.7	-1.1	0.0
Qualifications: nursing, teaching	1.1	1.7	4.8	0.2	1.8	0.1	1.5	0.4	2.2
Commuting to job workplace: Walk	1.1	1.2	2.8	-0.8	0.0	0.9	1.7	-0.4	1.7
Unable to work because of sickness or disability	1.1	1.5	3.9	0.5	-2.0	-0.9	-0.3	-1.5	-1.2
Alcohol drinker status: Previous	1.1	1.2	5.1	-0.2	-2.3	0.2	0.5	-1.3	-0.4
Hair/balding pattern: Pattern 2	1.0	1.3	2.5	-1.0	0.1	-1.6	-1.3	-1.4	-0.7
Hair/balding pattern: Pattern 3	1.0	1.5	5.1	0.4	-2.2	0.6	-0.3	-1.8	-0.5
Length of working week for main job	1.0	1.1	3.0	0.3	1.2	-1.3	-1.7	-0.1	-0.5
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.7	-0.3	0.2	-1.4	-1.6	-1.3	-1.3
Number of full brothers	1.0	1.3	3.5	0.0	0.9	1.1	0.9	1.9	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.2	3.7	-1.3	1.9	-0.6	0.2	-0.1	1.2
Medication: Blood pressure	1.0	1.8	9.3	-1.1	-0.1	-3.1	-0.3	-0.1	0.2
Eye problems/disorders: Glaucoma	1.0	1.2	2.5	0.8	-0.6	1.3	0.9	1.6	0.9
Medication: Paracetamol	1.0	1.6	3.9	2.0	0.4	1.6	1.2	0.5	1.0
Alcohol drinker status: Never	1.0	1.1	2.4	-1.6	1.1	-1.4	-1.0	-0.2	-0.6
Heart disease (siblings)	1.0	1.3	2.4	0.4	-0.7	1.5	1.2	1.6	0.8
BMI	0.9	5.0	14.0	1.5	2.3	0.6	1.6	3.7	2.4
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.5	0.2	1.4	1.1	0.9	-0.7	1.6
Trunk fat percentage	0.9	3.8	6.4	1.8	1.7	2.4	1.0	2.5	1.9
Fluid intelligence score	0.9	1.9	3.6	-1.8	-0.0	0.6	1.9	0.6	1.9
Medication: Cholesterol lowering	0.9	1.4	4.3	0.4	0.5	1.5	1.0	2.1	0.8
Peak expiratory flow (PEF)	0.9	2.2	5.3	-0.5	-1.5	-0.3	-1.6	-2.3	-1.6
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.5	0.1	-0.6	-1.3	-1.0	-0.9	-1.6
Worry too long after embarrassment	0.9	1.6	8.0	-2.8	0.2	-1.0	-0.3	-0.5	-0.2
Number of children fathered	0.9	1.0	1.8	1.4	-1.0	0.9	1.3	0.1	0.9
Shortness of breath walking on level ground	0.9	1.1	5.3	0.1	-1.0	-0.5	0.2	-2.3	-0.0
Leg pain on walking	0.9	1.2	3.0	-0.6	-0.0	-1.7	-1.3	-0.8	-1.2
Illnesses of father: None of the above (group 1)	0.9	1.1	3.5	0.7	1.3	1.9	0.2	1.0	0.1
Average weekly beer plus cider intake	0.9	1.3	2.8	1.7	-1.1	1.5	0.9	-0.1	0.8
Myopia	0.9	1.3	4.5	0.4	0.1	1.6	0.5	2.1	0.9
Vascular/heart problems diagnosed by doctor	0.9	2.5	12.5	1.1	0.4	3.5	0.8	0.4	0.2
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	4.4	2.1	1.1	0.9	-0.5	0.3	0.1
Schizophrenia (2018)	0.8	1.6	6.1	2.5	-1.1	1.3	-0.1	0.4	-0.6
HbA1C	0.8	0.9	2.3	-0.9	-0.0	0.3	-1.0	-1.1	-1.5
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.7	0.6	1.2	0.5	0.6	1.3	1.3
Relative age of first facial hair	0.8	1.7	3.0	-0.0	0.8	1.7	1.5	1.2	1.7
Maternal smoking around birth	0.8	1.2	3.4	-0.2	1.9	1.4	0.2	1.2	0.7
Pain all over the body in last month	0.8	0.9	3.2	-1.2	-1.8	0.3	0.7	-0.3	0.5
Medication: Ramipril	0.8	1.0	2.3	0.5	-1.5	-0.9	-1.3	-0.2	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.5	-0.7	1.4	-1.9	-0.4	-0.6	0.6
Body fat percentage	0.8	3.3	5.9	1.6	1.8	1.8	1.0	2.4	1.9
Emphysema/chronic bronchitis	0.8	0.9	2.2	-0.4	1.5	-1.2	-0.6	1.1	-0.4
Neck or shoulder pain in last month	0.8	1.2	2.2	0.6	1.2	1.5	1.0	-0.1	1.4
Medication: Allopurinol	0.8	1.1	2.2	1.5	0.1	0.1	-1.4	-0.6	-1.5
Medication: Omeprazole	0.8	1.0	4.5	2.1	0.7	0.9	-0.1	-0.1	0.4
Comparative height size at age 10	0.8	4.5	11.4	0.7	-1.9	0.7	-2.3	-2.4	-3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	3.6	0.3	-1.9	0.4	-0.1	-1.1	-0.7
Osteoarthritis (self-reported)	0.8	1.1	2.9	1.3	-0.1	-0.6	-0.7	-1.7	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	3.8	0.0	-0.5	1.7	1.7	0.9	1.9
Wears glasses or contact lenses	0.8	0.9	2.8	-0.3	-0.6	-1.1	-0.3	-1.7	-1.0
Medication: Atorvastatin	0.8	1.0	2.6	1.6	0.6	1.5	0.6	0.4	0.6
Number of operations (self-reported)	0.8	1.1	6.0	2.4	-0.5	-0.3	-0.5	-0.5	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	3.3	0.5	-0.5	-1.2	-0.7	-1.8	-0.6
Schizophrenia vs Biploar Disorder	0.7	0.9	4.2	2.0	0.5	0.7	0.4	0.7	0.3
Ulcerative Colitis (UC)	0.7	1.3	2.8	0.2	-0.1	-1.4	-1.7	-0.1	-1.7
Lupus	0.7	1.1	3.3	-1.8	-0.9	-0.6	-0.1	-1.4	-0.4
Hypothyroidism (self reported)	0.7	1.6	3.5	1.5	1.2	1.9	0.9	1.1	0.8
Medication: Metformin	0.7	1.0	1.8	0.8	-1.4	0.5	-0.9	-0.9	-1.2
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	1.4	0.8	-0.2	-1.1	-0.8	-1.2	-1.1
Qualifications: None of the above	0.7	1.6	2.9	1.5	-0.4	1.7	1.7	0.2	1.2
Worrier / anxious feelings	0.7	1.4	3.4	-1.1	-0.8	-1.4	-0.9	-1.8	-0.6
Lung cancer (father)	0.7	0.8	2.4	-0.4	-0.1	1.6	1.1	0.8	0.7
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	3.3	1.1	1.7	1.8	-0.0	0.5	0.4
Eye problems/disorders: None of the above	0.7	0.8	1.7	0.2	1.3	1.2	0.7	0.2	1.1
Mean time to correctly identify matches	0.7	1.3	2.8	-1.1	0.6	0.6	1.7	0.8	1.4
Supplements: Vitamin C	0.7	0.8	3.2	1.1	0.4	1.8	0.2	0.0	-0.2
Illnesses of father: Heart disease	0.7	1.0	3.2	-0.4	-1.8	-0.1	-0.5	-1.2	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.5	-1.1	0.6	1.0	0.5	0.3	1.2
Breast cancer (self-reported)	0.7	0.8	1.6	0.5	0.7	1.3	1.2	0.1	1.0
Arm fat mass (left)	0.7	2.7	6.0	1.4	1.7	1.4	0.9	2.4	1.5
Hearing aid user	0.7	0.8	2.0	1.1	-0.7	-0.7	-0.6	-0.1	-1.4
Age started oral contraceptive pill	0.7	0.9	2.4	-0.1	1.6	0.3	0.2	1.5	1.0
Diastolic blood pressure, automated reading	0.7	2.2	4.2	-0.5	2.0	-2.0	0.6	0.5	2.0
Heart attack/myocardial infarction (self-reported)	0.7	0.8	2.1	-0.5	0.7	1.4	0.8	1.1	0.7
Medication: Co-codamol	0.6	0.7	2.1	0.6	-1.4	-0.8	0.0	-0.6	-0.8
Medication: Atenolol	0.6	0.8	2.8	-1.1	-0.2	-1.7	-0.1	-0.2	-0.7
Trunk fat mass	0.6	2.4	3.8	1.7	1.5	1.9	0.4	1.9	1.2
Past tobacco smoking	0.6	1.1	3.9	2.0	0.4	1.1	0.5	1.1	0.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.8	-0.9	1.3	0.2	-0.0	1.3	0.5
Financial difficulties in last 2 years	0.6	0.8	1.7	-0.7	-0.6	-1.3	-0.7	-0.4	-1.2
Mouth/teeth dental problems: Dentures	0.6	1.1	4.4	2.1	0.4	1.3	0.0	-0.2	-0.1
Arm fat mass (right)	0.6	2.3	5.2	1.5	1.5	1.4	0.8	2.3	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	2.0	1.4	-0.9	-0.7	-0.9	0.3	-0.6
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.7	1.0	-1.0	1.3	0.9	0.0	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.4	1.2	-0.7	-0.3	-1.6	-1.1	-1.3
Long-standing illness, disability or infirmity	0.6	0.9	1.7	-1.2	0.9	-1.3	-0.8	-0.5	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	3.9	-1.1	0.5	-0.4	-0.1	-2.0	0.5
Medication for cholesterol	0.6	0.9	2.6	1.2	-1.0	1.6	0.2	0.0	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.9	-0.2	-1.2	0.4	-0.1	1.4	-0.7
Number of self-reported non-cancer illnesses	0.6	1.1	3.8	-0.4	-0.3	-1.9	0.5	-1.4	0.6
Miserableness	0.6	1.1	2.4	-1.5	1.0	-1.6	-0.7	-0.6	0.1
Tinnitus: Yes, now most or all of the time	0.6	0.8	1.4	0.3	-1.2	-0.9	-1.0	0.4	-1.0
Medication: Lisinopril	0.6	0.8	3.4	-0.7	0.1	-1.8	0.5	-0.5	0.6
Risk taking	0.6	0.8	3.7	-0.5	1.9	0.6	-0.3	0.6	0.6
Depression (Nagel 2018)	0.5	0.7	2.6	-0.3	1.6	-0.7	0.0	0.4	0.8
Breast Cancer	0.5	1.2	2.2	-0.7	1.2	0.1	1.0	1.4	1.5
Rheumatoid Arthritis	0.5	0.7	2.3	0.0	-1.5	0.5	0.8	-0.5	0.9
Height	0.5	9.2	17.3	0.5	-3.9	4.2	-1.0	-3.6	-2.9
Smoking Status	0.5	1.1	4.0	-2.0	-1.2	-0.5	-0.5	0.0	-0.9
Lung FVC	0.5	2.3	7.8	-2.8	1.2	0.1	1.4	0.9	1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.0	-0.5	-0.4	0.7	1.7	0.7	1.5
Medication: Levothyroxine sodium	0.5	0.9	2.9	1.0	1.0	1.7	0.3	-0.5	0.6
High blood pressure (mother)	0.5	0.8	2.4	1.6	-0.1	-0.5	-0.4	-1.3	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.6	-0.5	0.7	-1.6	-1.1	0.7	-0.2
Forced vital capacity (FVC)	0.5	2.0	5.3	-1.2	-2.3	0.4	-0.2	-2.0	-1.0
Diabetes (self-reported)	0.5	0.8	2.8	1.7	-0.2	1.2	0.2	0.7	0.5
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.8	-0.5	-1.4	-0.6	0.2	-1.2	-0.6
Hip circumference	0.5	1.9	4.3	2.1	0.7	1.6	1.0	1.2	1.4
Illnesses of mother	0.5	0.6	1.6	-0.3	-0.8	0.9	0.4	1.3	-0.7
Standing height	0.5	5.3	15.3	0.9	-2.2	1.3	-1.9	-3.9	-2.4
Breastfed as a baby	0.5	0.7	2.5	0.6	1.6	-0.5	-0.8	-0.2	-0.3
Gout (self-reported)	0.5	0.7	2.0	0.9	0.0	1.4	-0.6	0.6	-0.9
Whole body fat mass	0.5	2.2	3.8	1.6	1.4	1.7	0.6	1.9	1.3
Medication: Blood pressure	0.5	1.0	3.8	-0.0	0.8	-1.9	0.7	0.1	1.1
Major Depression (MDD)	0.4	0.4	2.1	-1.4	-0.1	-0.7	-0.2	0.1	-0.2
Prostate Cancer	0.4	0.5	1.2	-0.7	-0.5	-0.9	-0.5	-0.4	-1.1
Crohns Disease (2012)	0.4	0.7	3.0	0.1	1.1	0.1	0.3	1.7	0.0
Schizophrenia (2014)	0.4	0.9	1.8	1.3	0.4	1.0	-0.5	1.3	-0.6
Blood Platelet Count	0.4	4.2	11.0	3.3	0.3	1.4	1.9	1.4	2.5
Blood Red Count	0.4	3.7	5.1	2.3	1.7	1.5	2.2	1.3	2.1
Respiratory disease	0.4	1.0	3.4	1.8	-0.5	0.3	1.1	-0.1	1.1
Tanning	0.4	5.0	10.3	-1.2	-0.9	-2.4	-3.2	-1.7	-2.9
Number of treatments/medications taken	0.4	0.7	1.5	0.1	0.7	-0.8	0.8	-0.8	1.2
Hearing difficulty/problems: Yes	0.4	0.6	2.5	1.0	0.4	-0.3	0.1	1.6	0.1
Supplements: Zinc	0.4	0.4	0.9	-1.0	-0.1	-0.7	-0.9	0.3	-0.5
Qualifications: CSEs or equivalent	0.4	0.6	1.5	-0.3	0.9	0.6	-0.8	1.2	-0.2
Stomach or abdominal pain in last month	0.4	0.6	1.9	1.4	0.0	-0.7	0.3	-0.8	0.6
Body mass index (BMI)	0.4	1.8	5.5	1.2	1.3	0.5	0.8	2.4	1.2
Heart attack	0.4	0.6	1.7	-0.4	0.5	1.3	0.7	0.7	0.5
Illnesses of siblings	0.4	0.5	1.2	-0.5	0.6	0.7	1.1	0.0	0.8
Father’s age at death	0.4	0.5	1.0	0.5	-0.1	-1.0	-0.6	-0.8	-0.9
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	2.8	-1.1	-1.7	0.6	-0.7	-1.3	-1.0
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.7	-0.4	0.6	-1.7	-0.3	-1.2	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.0	0.8	-0.0	-0.3	0.6	0.5	1.0
Medication: Paracetamol	0.4	0.7	2.9	1.7	0.4	1.1	0.3	0.2	0.2
Headache pain in last month	0.4	0.7	2.3	0.4	1.5	-1.2	-0.4	-0.4	-0.3
Leg fat percentage (right)	0.4	1.4	2.6	1.1	1.6	0.4	0.4	1.5	1.4
Health satisfaction	0.4	0.5	1.4	-0.9	1.2	-0.8	-0.4	0.1	-0.1
Leg fat mass (right)	0.4	1.5	3.0	1.6	1.4	0.9	0.3	1.7	1.0
Overall health rating	0.4	0.9	2.1	0.8	1.5	-1.4	-0.7	-0.1	-0.4
Knee pain experienced in last month	0.4	0.6	1.1	-0.1	0.5	0.6	1.0	1.1	1.0
Illnesses of siblings: Diabetes	0.4	0.5	1.4	0.8	-0.3	1.2	0.2	0.6	0.4
Mood swings	0.4	0.7	2.0	-1.4	0.4	-0.4	0.3	0.8	1.0
Medication: Gliclazide	0.4	0.4	1.6	0.4	-0.8	1.3	0.0	0.3	-0.3
Commuting to job workplace: Public transport	0.4	0.5	1.6	-0.4	-0.2	0.1	1.3	-0.5	0.9
Leg fat percentage (left)	0.4	1.6	3.2	0.9	1.8	0.4	0.4	1.8	1.4
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.0	-0.9	0.3	0.7	-0.0	1.0	-0.4
Leg fat mass (left)	0.4	1.6	3.6	1.5	1.5	0.9	0.3	1.9	1.0
Bipolar Disorder or Schizophrenia	0.3	0.8	2.6	0.5	-1.6	0.2	-0.7	-0.1	-1.2
Depressed Affect (Nagel 2018)	0.3	0.7	1.7	-1.3	0.2	-1.0	-1.0	0.5	-0.3
Irritable Bowel Disease (IBD)	0.3	0.7	1.1	0.5	0.9	-0.8	-0.8	1.1	-0.9
Reaction Time	0.3	0.6	1.0	-0.6	1.0	0.5	0.9	0.8	0.7
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.9	-1.7	-1.1	-0.4	0.3	-0.6	0.0
Mean Putamen Volume	0.3	0.4	0.8	0.6	0.2	0.3	-0.9	0.1	-0.9
LDL Cholesterol	0.3	0.5	1.4	-0.6	-1.2	0.2	0.1	-1.2	-0.0
Systolic blood pressure, automated reading	0.3	0.8	3.5	0.3	0.6	-1.9	-0.7	-0.7	-0.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.9	0.7	-0.1	0.4	-0.5	-0.9	-0.2
Medication for hormone replacement therapy	0.3	0.4	1.2	-1.1	-0.1	-0.2	-0.4	-0.7	-0.5
Vitamin and mineral supplements	0.3	0.4	1.1	-0.3	0.6	-1.0	-0.2	-0.8	-0.2
Impedance of leg (right)	0.3	1.2	6.1	-0.1	-0.6	-0.3	-0.8	-2.5	-0.6
Current tobacco smoking	0.3	0.5	0.9	-0.9	-0.7	-0.2	-0.7	-0.1	-0.9
Relative age voice broke	0.3	0.4	0.9	-0.1	0.9	0.4	0.6	-0.5	1.0
Age when periods started (menarche)	0.3	0.6	1.2	-0.8	1.1	0.6	0.9	0.4	0.9
Multivitamins +/- minerals	0.3	0.4	1.1	-0.2	-1.0	0.4	-0.5	0.6	-0.5
Hearing difficulty/problems with background noise	0.3	0.4	1.3	0.1	1.2	0.0	0.0	1.0	0.6
Mouth/teeth dental problems	0.3	0.4	1.7	-0.8	0.4	0.3	0.0	1.3	-0.3
Medication: Simvastatin	0.3	0.4	1.8	-0.1	0.8	-0.4	-0.2	1.3	0.1
Trunk fat-free mass	0.3	1.8	3.7	0.3	-1.3	-0.6	-1.4	-1.9	-1.7
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.2	1.1	0.6	0.1	0.6	0.6	1.0
Happiness	0.3	0.3	0.7	-0.0	0.9	0.8	-0.3	0.6	-0.3
Medication: Lansoprazole	0.3	0.3	1.3	1.1	-0.3	-0.5	0.3	-0.1	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.4	-0.5	-1.5	0.6	-0.4	-1.6	-0.6
Impedance of arm (left)	0.3	1.2	5.5	0.5	0.2	2.3	0.7	0.1	1.1
Trunk predicted mass	0.3	1.8	3.6	0.3	-1.3	-0.6	-1.5	-1.9	-1.8
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.3	-0.6	1.1	0.5	-0.3	-0.6	0.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.3	-0.1	-0.2	0.2	0.8	0.1	1.1
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	0.9	0.7	-0.4	0.9	-0.6	-0.8	-0.9
Forced vital capacity (FVC), Best measure	0.3	1.1	3.4	-0.7	-1.5	0.5	0.2	-1.9	-0.3
Arm fat-free mass (right)	0.3	1.5	3.3	0.2	-1.2	-0.4	-1.3	-1.8	-1.6
Qualifications: College or University degree	0.3	1.1	2.8	-1.7	1.3	-1.3	0.0	-0.4	0.5
Medication for pain relief, constipation, heartburn	0.3	0.5	2.4	-1.6	-0.1	-0.2	0.8	0.2	0.1
Medication: Ibuprofen	0.3	0.3	0.8	-0.8	0.9	-0.0	-0.8	-0.1	0.1
Heart disease (mother)	0.3	0.4	1.3	-0.4	0.4	-1.1	-1.0	-0.1	-0.0
Family relationship satisfaction	0.3	0.3	0.6	0.2	-0.8	-0.1	-0.5	-0.7	-0.7
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.2	0.3	-0.8	1.1	0.1	0.4	-0.1
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.7	0.8	0.8	-0.3	-0.4	-0.9	-0.0
Loneliness, isolation	0.3	0.4	1.1	-0.6	1.1	-0.1	-0.5	0.4	0.5
Diabetes diagnosed by doctor	0.3	0.5	2.5	1.6	-0.0	0.4	-0.3	0.0	-0.1
Mineral and other dietary supplements	0.3	0.4	1.3	0.8	0.3	-0.3	-0.2	1.1	0.0
Smoking status: Current	0.3	0.5	1.2	-1.1	-0.9	-0.0	-0.7	-0.0	-0.8
Average weekly champagne plus white wine intake	0.3	0.4	0.9	-0.1	0.8	1.0	0.3	0.9	0.3
Financial situation satisfaction	0.3	0.4	1.6	1.2	0.2	-0.2	0.5	0.4	-0.2
Supplements: Fish oil (including cod liver oil)	0.3	0.3	1.1	-0.4	0.0	1.0	0.5	-0.4	0.6
Arm fat-free mass (left)	0.3	1.3	2.6	0.7	-0.8	-0.4	-1.3	-1.4	-1.6
Cholesterol lowering medication	0.3	0.5	2.4	0.2	1.5	-0.1	-0.5	-0.3	-0.0
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.3	-1.1	-0.5	-0.6	1.0	-0.7	0.8
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.7	-0.6	-0.4	-0.1	0.2	-0.1
Alzheimer’s Disease (including proxy)	0.2	0.3	0.5	0.6	0.7	0.2	0.1	0.6	0.3
Ovarian Cancer	0.2	0.3	1.3	1.2	0.2	0.6	0.3	-0.3	-0.2
Bipolar Disorder (2011)	0.2	0.2	1.3	-1.2	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.7	0.8	-0.0	-0.1	0.8	0.2	0.6
Coronary Artery Disease (CAD)	0.2	0.3	1.5	1.2	-0.2	-0.1	0.2	-0.2	-0.1
HDL Cholesterol	0.2	0.3	1.0	-1.0	-0.2	-0.4	-0.4	-0.6	-0.4
Heel T-Score	0.2	1.4	3.8	-1.9	0.0	-1.8	0.5	-0.8	0.5
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.0	1.0	0.1	0.4	0.5	0.6	0.8
Lung FEV1/FVC ratio	0.2	0.9	1.7	1.3	-0.6	1.3	-1.0	-0.0	-1.0
Hand grip strength (left)	0.2	0.6	1.7	0.0	-1.1	0.2	-0.7	-0.2	-1.3
Angina	0.2	0.3	0.9	0.2	0.2	0.5	-0.9	0.1	-0.6
Diabetes (father)	0.2	0.3	0.7	0.7	-0.8	-0.1	-0.3	-0.6	-0.3
Severe depression (siblings)	0.2	0.2	0.5	0.7	-0.6	-0.3	-0.3	-0.2	-0.5
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.0	-1.0	-0.2	-0.6	-0.5	-0.8	-0.7
Supplements: Glucosamine	0.2	0.3	1.5	-1.2	-0.2	-0.3	-0.1	-0.5	-0.1
Impedance of leg (left)	0.2	1.0	4.1	-0.4	-0.2	-0.3	-1.0	-2.0	-0.7
Waist circumference	0.2	0.9	4.6	2.1	0.2	0.3	-0.4	0.6	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.1	0.1	-0.6	-0.3	1.0	0.0	1.0
Impedance of arm (right)	0.2	0.9	3.1	1.0	0.5	1.8	0.5	0.1	1.1
Noisy workplace	0.2	0.2	1.0	-0.4	1.0	0.1	0.1	0.1	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.6	0.4	0.8	0.3	-0.5	-0.2	0.4
Hair/balding pattern: Pattern 4	0.2	0.4	1.4	-1.2	-0.2	-0.5	-0.4	-0.3	-0.8
Birth weight of first child	0.2	0.4	1.0	1.0	0.3	0.7	-0.0	-0.7	-0.5
Exposure to tobacco smoke outside home	0.2	0.2	0.9	-0.9	-0.3	-0.5	-0.2	-0.0	-0.1
Comparative body size at age 10	0.2	0.6	1.6	-1.3	-0.3	-0.9	-0.7	0.7	-0.3
Wheeze or whistling in the chest in last year	0.2	0.4	1.0	0.2	1.0	-0.8	-0.4	-0.6	0.4
Angina (self-reported)	0.2	0.3	0.9	0.1	-0.3	0.5	-0.9	-0.0	-0.6
Arm predicted mass (right)	0.2	1.3	2.4	0.6	-1.2	0.0	-1.1	-1.5	-1.4
Alcohol intake frequency.	0.2	0.5	1.1	0.0	1.1	-0.7	0.2	1.0	0.0
Chest pain or discomfort	0.2	0.3	0.7	0.2	-0.2	-0.7	-0.6	-0.8	0.2
Medication: Aspirin	0.2	0.2	0.4	-0.0	0.5	-0.5	0.2	-0.7	0.6
Friendships satisfaction	0.2	0.2	0.9	0.6	0.9	-0.1	-0.3	0.1	-0.0
Osteoporosis (self-reported)	0.2	0.2	0.8	-0.9	0.4	-0.3	0.4	0.2	0.5
Ever depressed for a whole week	0.2	0.2	0.6	-0.7	0.4	-0.8	-0.1	0.1	-0.1
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	0.2	-0.5	-0.6	0.5	-0.3	0.4
Arm predicted mass (left)	0.2	0.9	1.7	0.7	-0.8	-0.1	-1.0	-1.1	-1.3
Primary Biliary Cirrhosis	0.1	0.1	0.4	-0.1	-0.4	-0.2	0.3	-0.6	0.3
Blood White Count	0.1	0.9	2.5	1.6	-1.5	-0.6	0.3	0.3	-0.3
Allergy or Eczema	0.1	0.2	0.7	0.4	0.1	-0.1	-0.1	-0.9	-0.2
Leg fat-free mass (left)	0.1	0.6	1.8	1.4	-0.7	1.1	-0.4	0.3	-0.3
Townsend deprivation index at recruitment	0.1	0.1	0.5	0.2	0.5	0.1	-0.1	0.7	0.1
Sitting height	0.1	0.6	1.1	-0.1	0.2	1.1	-1.1	-0.9	-0.6
Leg predicted mass (left)	0.1	0.6	1.8	1.3	-0.7	1.1	-0.4	0.2	-0.4
Weight	0.1	0.7	2.6	1.6	0.3	1.0	-0.2	0.4	-0.0
Tense / ‘highly strung’	0.1	0.2	0.7	-0.6	0.8	-0.3	-0.2	-0.2	0.4
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.6	0.8	0.2	0.2	-0.3	-0.2	-0.1
Migraine (self-reported)	0.1	0.1	0.6	0.1	0.8	-0.1	-0.2	0.0	0.2
Had major operations	0.1	0.1	0.3	0.4	-0.3	-0.1	0.5	-0.4	0.3
Smoking status: Previous	0.1	0.2	0.6	-0.8	-0.1	-0.6	-0.0	-0.6	-0.1
Whole body fat-free mass	0.1	0.8	1.4	0.7	-1.0	0.0	-1.0	-1.1	-1.2
Leg fat-free mass (right)	0.1	0.5	1.0	1.0	-0.4	1.0	-0.5	0.5	-0.4
Medication: Aspirin	0.1	0.1	0.4	0.1	0.3	-0.6	0.1	-0.5	0.2
Whole body water mass	0.1	0.8	1.4	0.7	-0.9	0.1	-1.0	-1.0	-1.2
Leg predicted mass (right)	0.1	0.5	1.2	1.1	-0.5	1.0	-0.6	0.4	-0.5
High cholesterol (Self-reported)	0.1	0.1	0.2	0.1	0.4	0.1	-0.4	0.5	0.0
Basal metabolic rate	0.1	0.5	0.8	0.9	-0.7	0.4	-0.7	-0.6	-0.8
Pain experienced in last month	0.1	0.2	0.5	-0.4	-0.2	0.5	0.7	0.1	0.5
Impedance of whole body	0.1	0.4	1.6	0.1	-0.0	1.3	-0.1	-1.0	0.2
Blood Eosinophil Count	0.0	0.3	0.4	0.4	0.6	0.0	-0.6	-0.5	-0.6
Hair Pigment	0.0	0.8	2.7	0.9	0.2	0.4	0.9	0.4	1.6
Number of incorrect matches in round	0.0	0.0	0.1	0.1	0.2	-0.2	-0.2	0.2	0.1
Allergy	0.0	0.1	0.3	0.3	-0.3	0.3	-0.2	0.5	-0.2

Hub : Genes

LOC158376

Models

Trait associations