Hub : Genes

SMC6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0610 0.0230 1.1e-03 0.035 0.028 0.033 0.03 0.023 3.4e-05 1.8e-04 6.6e-05 0.00012 8.0e-04
2 GTEx Cells Transformed fibroblasts 0.2570 0.0630 2.4e-07 0.112 NA 0.068 NA 0.037 9.4e-09 NA 7.6e-06 NA 8.3e-04
3 GTEx Esophagus Mucosa 0.1660 0.0540 4.2e-04 0.010 NA 0.039 NA 0.011 6.8e-02 NA 1.3e-03 NA 5.8e-02
4 GTEx Esophagus Muscularis 0.2000 0.0690 2.8e-03 0.069 NA 0.009 NA 0.051 5.3e-05 NA 8.8e-02 NA 4.4e-04
5 GTEx Liver 0.2470 0.0800 2.4e-04 0.227 NA 0.138 NA 0.207 5.7e-07 NA 1.1e-04 NA 1.9e-06
6 GTEx Skin Not Sun Exposed Suprapubic 0.2020 0.0710 1.7e-03 0.021 NA 0.058 NA 0.060 2.5e-02 NA 4.2e-04 NA 3.3e-04
7 GTEx Small Intestine Terminal Ileum 0.2880 0.1060 5.6e-03 0.129 NA 0.005 NA 0.030 8.3e-04 NA 2.4e-01 NA 7.4e-02
8 GTEx Thyroid 0.0980 0.0320 3.3e-05 0.108 NA 0.103 NA 0.110 1.3e-08 NA 2.7e-08 NA 9.2e-09
9 TCGA Kidney Renal Papillary Cell Carcinoma 0.0890 0.0540 4.6e-03 0.043 0.043 0.022 NA 0.045 1.6e-03 1.8e-03 1.9e-02 NA 1.4e-03
10 TCGA Brain Lower Grade Glioma 0.0734 0.0309 1.1e-08 0.099 0.080 0.074 NA 0.044 2.5e-11 2.2e-09 8.0e-09 NA 8.3e-06
11 TCGA Prostate Adenocarcinoma 0.0776 0.0398 7.6e-05 0.020 0.050 0.055 NA 0.028 3.5e-03 5.6e-06 1.8e-06 NA 6.1e-04
12 TCGA Thyroid Carcinoma 0.0300 0.0170 2.8e-03 0.025 0.025 -0.001 NA 0.013 1.6e-03 1.5e-03 3.9e-01 NA 1.7e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 0.6 1.0 5.3 0.3 -0.8 -1.1 -1.2 -0.4 -2.3 0.1 0.3 -0.7 0.7 -1.1 -0.7
Bipolar Disorder or Schizophrenia 0.8 1.9 5.2 2.3 0.2 -0.1 -0.5 1.2 -1.2 1.6 -1.6 1.1 -1.1 1.1 -2.3
Depressed Affect (Nagel 2018) 0.6 1.3 3.7 -0.6 -1.5 -1.4 1.0 -0.8 0.7 -1.1 0.8 -1.9 1.5 -1.2 0.5
Depression (Nagel 2018) 0.3 0.4 1.2 -0.6 -0.6 -1.0 -0.1 -0.4 0.8 -0.3 0.7 -0.1 1.1 1.0 -0.2
Intelligence (Savage-Jansen 2018) 0.2 0.6 2.1 -1.5 0.5 0.3 -1.1 0.6 -0.5 1.0 -0.6 -0.4 -0.5 -0.7 -0.9
Neuroticism (Nagel 2018) 1.4 3.2 7.4 -1.0 -1.9 -2.2 -0.3 -1.8 1.6 -2.0 1.5 -2.7 2.3 -1.8 1.1
Schizophrenia (2018) 1.7 3.5 7.7 2.8 1.3 0.8 0.4 1.9 0.3 2.0 -2.3 2.0 -2.0 2.3 -2.3
Schizophrenia vs Biploar Disorder 0.9 1.2 5.6 2.0 -0.1 -0.1 2.4 0.6 1.2 0.4 -1.0 0.6 -0.8 0.4 -1.0
Worry (Nagel 2018) 2.2 4.7 10.8 -2.1 -1.8 -2.0 -0.3 -2.5 1.2 -2.6 2.0 -3.3 2.6 -2.5 1.5
Alzheimer’s Disease (in mother) 0.4 0.4 1.4 0.9 -0.2 -0.9 -0.0 0.2 -0.2 0.0 -0.8 -0.0 -0.2 -1.2 -1.0
Alzheimer’s Disease (in father) 0.6 0.6 2.6 0.2 0.6 0.8 1.6 0.8 1.2 1.0 -0.7 -0.2 -0.6 0.2 -0.5
Alzheimer’s Disease (including proxy) 0.3 0.5 2.5 -0.0 -0.4 -1.1 0.6 -0.4 0.5 -0.3 -0.1 -0.7 0.4 -1.6 -0.5
Crohns Disease (2017) 0.4 0.8 2.1 0.5 -1.4 -0.9 -1.4 -0.6 -1.1 -0.5 0.5 -0.2 1.1 -1.0 0.0
Irritable Bowel Disease (IBD) 0.2 0.4 1.4 1.2 -1.1 -0.3 -0.5 -0.4 -0.6 -0.4 0.0 0.6 0.5 0.0 0.3
Ulcerative Colitis (UC) 0.3 0.6 2.8 1.7 -0.5 0.6 0.5 0.2 -0.3 0.2 -0.8 1.2 -0.5 1.1 -0.0
Major Depression (MDD) 0.2 0.2 0.8 0.1 -0.2 -0.2 0.4 0.2 -0.9 0.2 -0.2 0.7 0.2 0.9 -0.3
Reaction Time 1.2 2.3 7.0 2.2 -0.4 -0.5 -0.2 1.6 -1.1 1.7 -1.8 1.7 -1.5 0.7 -2.6
Verbal and Numeric Reasoning (VNR) 0.4 0.9 3.8 -1.7 -0.5 -0.4 0.4 -0.4 0.0 -0.0 0.4 -1.8 0.3 -2.0 -0.3
Breast Cancer 0.5 1.3 2.9 1.3 1.0 1.4 -1.5 1.1 -0.5 1.4 -1.0 -0.1 -1.7 1.2 0.3
Ovarian Cancer 0.4 0.5 1.2 0.1 -0.3 1.1 0.0 0.7 -1.0 0.7 -0.6 0.9 -1.0 0.9 -0.1
Prostate Cancer 6.2 8.7 13.1 3.5 3.1 2.3 2.8 3.6 0.3 3.4 -2.9 3.0 -3.2 3.6 -2.0
Age at First Birth 0.5 0.8 2.5 -0.4 -1.2 -0.8 -0.7 -0.7 0.6 -0.8 0.9 -1.6 1.0 -0.1 0.7
Bipolar Disorder (2011) 0.2 0.2 0.4 0.3 -0.4 -0.6 0.1 0.1 -0.4 0.4 -0.2 -0.4 0.0 -0.6 -0.6
Body Mass Index (BMI) (2010) 0.2 0.3 1.5 1.2 0.2 0.0 -0.2 0.3 -1.0 -0.0 -0.2 0.2 -0.4 -0.5 -0.1
Coronary Artery Disease (CAD) 0.9 1.1 3.7 -0.2 1.0 1.9 -1.6 0.4 1.2 -0.1 -0.5 0.1 -1.4 0.8 1.1
Crohns Disease (2012) 0.8 1.3 2.5 -0.6 -0.6 -0.7 -1.2 -1.3 0.1 -1.2 1.4 -1.6 1.3 -1.6 0.9
Mean Putamen Volume 0.3 0.3 1.3 0.4 -0.0 0.4 -0.7 -0.6 -0.6 -0.4 0.0 -0.9 0.3 -1.2 0.1
Fasting Glucose 0.6 0.7 2.8 1.3 1.2 0.4 0.2 0.2 -1.0 0.4 -0.6 -0.4 -0.0 -1.7 -0.5
HbA1C 0.4 0.4 1.9 0.8 -0.7 0.5 -0.2 0.0 -1.4 0.3 0.3 1.1 -0.2 -0.1 -0.7
HDL Cholesterol 1.0 1.6 6.0 0.1 1.6 2.4 0.1 1.3 0.9 1.2 -1.1 1.1 -1.8 0.9 0.1
LDL Cholesterol 0.8 1.3 6.2 0.4 1.4 2.5 0.4 0.4 1.1 0.3 -0.1 0.3 -1.0 0.9 1.9
Lupus 2.6 3.9 15.4 -0.6 -1.3 -2.1 1.1 -2.1 1.2 -1.7 1.9 -3.9 2.0 -1.9 1.8
Neuroticism (2016) 0.2 0.3 1.5 -0.3 -0.4 0.7 -1.2 0.1 0.3 0.1 -0.6 -0.4 -0.2 -0.5 -0.4
Primary Biliary Cirrhosis 0.4 0.6 2.5 0.5 0.3 1.6 -1.3 0.7 -0.4 0.8 -0.5 0.1 -0.4 0.5 -0.5
Rheumatoid Arthritis 0.8 1.1 6.0 -0.3 0.1 -0.4 -2.4 -1.1 0.0 -1.3 1.5 0.3 1.1 -0.3 0.6
Schizophrenia (2014) 2.4 5.2 9.3 2.6 1.7 0.8 0.1 2.5 0.6 2.7 -2.9 2.6 -2.4 2.9 -3.0
Triglycerides 0.1 0.2 0.8 0.9 0.2 -0.2 -0.4 -0.2 -0.3 -0.1 0.4 -0.0 0.4 0.0 0.7
Type 2 Diabetes (T2D) (2012) 1.3 1.5 3.7 -1.0 -1.7 -1.9 -0.2 -0.9 -1.8 -0.7 0.6 -0.6 1.4 -1.5 -0.5
Ulcerative Colitis 0.3 0.4 1.4 0.8 -0.2 0.6 -1.2 -0.4 0.4 -0.3 -0.1 0.1 -0.2 0.8 0.9
Blood Eosinophil Count 0.1 1.1 2.8 -1.0 -1.5 -1.7 -0.5 -1.0 -0.1 -1.1 0.9 -1.0 1.2 -1.0 0.3
Blood Platelet Count 0.1 0.6 2.1 0.6 0.7 1.4 0.5 -0.2 1.2 0.1 -0.2 -0.8 -0.1 0.5 1.2
Blood Red Count 0.1 1.0 3.3 0.2 0.2 1.3 -0.5 -0.2 0.9 -0.8 1.5 1.1 0.1 1.3 1.8
Blood White Count 0.2 1.2 4.8 0.2 -1.3 0.1 0.2 -1.4 -0.2 -1.0 1.8 -0.5 1.2 -0.3 2.2
Heel T-Score 0.1 0.8 3.6 0.4 -0.0 1.9 -0.7 -0.1 -0.4 0.1 0.2 1.8 -0.3 1.1 0.8
BMI 0.1 0.7 5.2 2.3 0.0 -0.8 -0.3 0.2 0.5 0.1 0.8 0.2 0.4 1.0 0.2
Height 0.2 3.6 16.4 -1.9 -2.2 0.6 -1.1 -1.5 -0.8 -2.3 2.7 0.2 1.0 0.3 4.0
Waist Hip Ratio (WHR) 0.1 0.5 0.9 -0.8 0.9 0.9 0.4 0.8 0.9 0.7 -0.4 0.6 -0.8 0.8 0.2
Systolic Blood Pressure 1.4 7.0 13.9 3.2 3.7 2.1 1.9 3.1 0.0 2.4 -2.0 3.7 -2.9 2.7 -1.9
Smoking Status 1.1 2.7 14.0 1.6 0.1 0.3 3.7 1.3 -1.7 1.8 -1.6 0.1 -0.9 -0.6 -2.0
Allergy or Eczema 0.3 0.8 4.2 -0.3 -0.8 -2.0 -0.2 -0.8 0.2 -0.4 0.6 -0.5 1.2 -1.1 -0.3
Cardiovascular Disease 1.6 5.3 8.0 2.4 2.8 2.7 1.2 2.8 1.2 2.1 -2.2 2.7 -2.7 2.8 -1.0
Hypothyroidism (self reported) 0.3 0.6 1.3 -1.1 -0.7 -0.3 1.1 -0.5 -0.9 -0.6 1.1 -0.6 0.8 -0.8 0.3
Respiratory disease 0.1 0.2 0.4 0.7 0.2 0.3 0.2 0.5 0.4 0.3 -0.6 0.6 -0.2 -0.2 0.0
Type 2 Diabetes (T2D) (2018) 3.4 6.3 19.2 2.9 1.3 0.0 2.4 2.8 -0.9 2.9 -3.4 2.5 -2.4 0.9 -4.4
Lung FEV1/FVC ratio 1.1 5.4 15.6 2.9 0.5 2.7 3.1 -1.9 0.6 -1.8 3.0 -2.1 1.6 -0.7 4.0
Lung FVC 0.4 2.1 5.1 -1.9 -0.7 -0.8 2.3 -1.6 -0.1 -2.1 0.6 -1.5 1.4 -1.9 0.7
Neuroticism 0.5 1.3 3.8 0.0 -1.4 -2.0 0.1 -0.7 1.4 -0.9 0.4 -1.4 1.2 -1.5 -0.6
Chronotype (morning person) 1.4 3.2 9.5 -1.8 1.2 0.5 -1.9 -1.4 2.8 -2.1 1.9 -0.5 1.2 0.6 3.1
Hair Pigment 0.1 1.5 3.4 -0.2 -1.2 -0.5 -1.2 -1.0 1.9 -0.9 1.1 -1.8 0.9 -1.5 1.3
Tanning 0.1 0.8 2.0 0.2 -0.5 0.6 -1.3 -1.0 0.9 -1.0 0.6 0.1 0.5 1.4 1.4
Hand grip strength (left) 1.9 5.0 11.4 -2.5 -1.8 0.0 -0.7 -2.7 -0.7 -3.0 3.1 -1.5 2.7 -1.5 3.4
Number of treatments/medications taken 0.4 0.6 1.7 1.3 -0.9 -0.6 0.6 0.5 -0.1 0.4 -0.7 1.2 -0.4 0.7 -1.2
Average weekly spirits intake 0.9 1.1 2.7 0.9 1.0 1.4 1.6 0.7 1.2 0.8 -1.1 0.8 -1.2 1.3 -0.2
Sensitivity / hurt feelings 1.3 2.2 5.2 0.3 -1.4 -2.2 -2.0 -1.5 0.4 -1.8 1.0 -1.6 1.1 -2.3 0.1
Frequency of depressed mood in last 2 weeks 0.9 1.3 4.9 -1.3 -0.8 -2.2 -0.6 -1.1 0.3 -1.0 0.9 -1.5 1.6 -0.2 -0.0
Hearing difficulty/problems: Yes 1.3 2.1 4.7 2.2 0.9 0.9 -0.3 1.7 -1.8 2.1 -1.6 0.1 -1.3 0.5 -1.8
Relative age of first facial hair 1.2 2.5 5.8 -2.4 -2.1 -0.8 -2.3 -1.9 -0.2 -1.6 1.1 -1.5 1.4 -1.4 1.0
Other serious medical condition/disability diagnosed by doctor 2.7 3.5 7.1 1.4 1.5 1.0 1.1 2.7 -1.6 2.4 -2.5 1.1 -2.5 1.5 -2.1
Ever used hormone-replacement therapy (HRT) 1.1 1.4 8.3 0.3 -0.2 -0.4 -0.9 0.7 -0.5 1.1 -1.6 1.4 -0.9 -0.3 -2.9
Ever had hysterectomy (womb removed) 1.1 1.3 2.8 -0.2 1.7 -0.2 -0.7 1.5 -1.0 1.4 -1.2 1.2 -1.0 0.8 -1.4
Systolic blood pressure, automated reading 1.8 5.4 10.0 3.1 3.2 1.6 1.3 2.7 1.4 2.3 -2.0 2.6 -2.8 2.0 -1.8
Eye problems/disorders: Diabetes related eye disease 4.2 4.6 14.3 1.8 0.2 0.4 0.7 2.3 -2.3 2.2 -2.6 2.8 -2.1 1.3 -3.8
Angina 0.7 0.9 2.6 0.7 0.1 -0.5 -1.5 1.2 -0.3 1.6 -0.7 0.4 -0.8 0.7 -1.3
Medication for hormone replacement therapy 2.6 2.9 6.4 -1.4 -1.5 -2.5 -1.5 -1.8 0.6 -1.7 1.4 -1.9 2.3 -2.0 0.3
Vitamin and mineral supplements 2.0 2.7 7.1 1.1 2.0 2.2 0.1 1.5 0.5 1.7 -1.0 2.6 -1.3 2.7 -0.4
Supplements: Zinc 0.6 0.7 2.3 0.6 -1.5 -0.7 0.6 -0.7 -1.1 -0.5 0.8 -0.6 0.9 -1.0 -0.1
Medication: Co-codamol 0.1 0.2 0.4 0.1 -0.4 -0.5 -0.6 -0.4 -0.4 -0.2 0.1 0.5 0.3 -0.1 -0.5
Medication: Metformin 1.9 2.7 11.6 1.5 -0.3 -1.2 0.6 1.5 -1.2 1.6 -2.5 1.5 -1.3 -0.4 -3.4
Diabetes (father) 4.0 5.0 14.7 2.6 2.6 2.3 1.4 2.2 -0.7 2.0 -1.2 3.8 -1.9 2.7 -1.6
Diabetes (mother) 0.8 1.0 2.6 0.4 0.9 1.2 0.9 1.0 -0.8 0.7 -1.6 1.3 -1.4 0.5 -0.9
Severe depression (siblings) 0.9 1.0 3.9 -0.1 -0.4 -0.4 2.0 -0.0 -1.1 -0.3 -0.5 -1.3 0.6 -1.9 -0.0
Pack years adult smoking proportion 0.6 0.9 4.3 1.5 0.6 0.7 -0.1 0.5 0.4 0.5 -0.2 1.4 -0.9 2.1 0.3
Impedance of leg (right) 0.1 0.7 2.1 -0.7 0.5 0.8 -0.3 0.8 -1.4 0.9 -1.2 0.5 -0.9 0.5 -0.8
Leg fat-free mass (left) 0.3 1.9 7.2 0.2 -0.7 -0.6 0.1 -1.3 0.8 -1.6 2.7 -0.6 1.5 -0.2 2.6
Trunk fat percentage 0.1 0.5 4.5 2.1 0.2 -0.5 -0.8 0.2 0.9 0.1 0.4 0.0 -0.2 0.2 0.1
Hand grip strength (right) 1.4 3.8 10.4 -1.2 -1.3 -0.2 0.3 -2.4 -0.5 -2.6 3.2 -1.2 2.6 -1.1 3.2
Townsend deprivation index at recruitment 0.1 0.2 0.5 0.3 0.5 -0.6 0.7 -0.2 -0.4 -0.1 0.3 0.0 0.4 0.4 0.2
Current tobacco smoking 0.1 0.2 1.4 0.0 -0.6 0.0 0.4 -0.3 -1.2 0.2 0.4 0.1 0.1 0.3 0.3
Average weekly fortified wine intake 3.1 3.6 6.2 1.2 2.5 2.2 2.2 2.1 0.8 1.9 -2.0 1.9 -2.5 1.5 -1.2
Maternal smoking around birth 1.1 1.5 7.2 1.1 -2.7 -1.1 -0.8 -1.5 0.3 -1.4 1.0 -0.6 1.6 -0.3 0.1
Fed-up feelings 0.5 0.8 3.0 -1.1 -0.8 -0.7 0.3 -0.7 1.2 -0.9 0.2 -1.7 0.6 -0.9 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.3 1.7 -0.5 -1.3 -0.6 -0.3 -0.4 -0.7 -0.1 0.5 -0.2 0.8 0.1 -0.3
Relative age voice broke 0.4 0.6 3.6 -1.9 -0.8 1.0 -0.5 -0.6 -0.1 -0.7 -0.1 -0.4 -0.3 -0.6 0.6
Taking other prescription medications 2.1 3.3 8.1 2.5 -0.7 0.3 0.0 1.9 -2.1 2.2 -2.1 1.7 -1.9 1.2 -2.8
Age when periods started (menarche) 3.0 7.2 12.6 -2.7 -2.5 -1.1 0.3 -3.3 0.5 -3.4 3.4 -3.1 3.1 -2.5 3.5
Bilateral oophorectomy (both ovaries removed) 1.5 1.7 8.6 0.2 -0.1 -0.2 -1.0 1.2 -1.0 1.0 -2.3 0.6 -1.0 -0.7 -2.9
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 3.1 -0.3 -1.2 0.6 -1.7 -1.1 -0.9 -1.3 1.8 0.0 0.8 -0.6 1.6
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 2.0 -0.8 -0.7 -1.4 0.1 -0.8 -0.4 -0.9 0.1 -1.4 0.9 -0.8 -0.3
Qualifications: CSEs or equivalent 0.9 1.1 2.0 1.3 1.4 1.4 -0.1 1.0 -0.9 1.1 -1.1 0.7 -1.3 1.1 -0.4
Serious illness, injury or assault to yourself 3.9 4.7 16.4 2.5 0.4 -0.8 0.6 2.9 0.0 3.1 -2.9 1.5 -1.7 1.4 -4.0
High blood pressure 2.2 6.2 12.7 3.6 2.2 1.6 1.5 3.0 0.2 2.5 -2.8 3.0 -2.9 2.5 -2.5
Hayfever, allergic rhinitis or eczema 0.5 1.0 4.3 -1.2 -0.8 -2.1 0.8 -0.1 -0.2 0.2 -0.3 -1.1 0.8 -1.4 -1.0
Multivitamins +/- minerals 0.9 1.2 4.9 0.1 -1.0 -1.3 -0.4 -0.9 -0.1 -0.8 0.8 -1.9 0.8 -2.2 0.3
Stomach or abdominal pain in last month 0.7 0.9 3.8 0.6 -1.0 -1.9 0.7 0.1 -0.0 0.1 -0.6 0.0 0.6 -0.5 -1.9
Supplements: Glucosamine 0.2 0.2 1.1 0.8 -0.3 0.1 -0.2 -0.3 -0.1 -0.1 0.4 -0.5 0.5 -1.0 -0.2
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 1.9 0.2 -0.7 -1.4 0.2 -0.1 -0.3 -0.7 -0.1 -1.0 0.3 -0.8 -0.5
Medication: Atenolol 0.4 0.5 2.2 1.1 -0.2 0.0 0.7 0.2 -0.7 -0.0 -0.2 1.5 -0.3 0.4 -0.8
Medication: Levothyroxine sodium 0.2 0.3 1.3 -0.3 -0.2 1.2 0.2 -0.2 -0.9 -0.2 0.3 -0.5 -0.1 0.3 0.5
Sitting height 0.3 2.0 12.9 0.9 -1.5 -0.2 1.3 0.9 -3.6 0.8 -0.3 1.5 -0.2 0.7 -1.2
Chronic bronchitis/emphysema (father) 0.2 0.3 1.3 0.7 0.9 -1.1 0.1 -0.1 0.2 0.4 0.1 0.2 0.2 0.3 -0.4
High blood pressure (mother) 1.5 2.1 7.5 1.1 2.7 1.8 1.1 1.4 1.2 1.2 -0.7 1.6 -1.4 1.2 -0.8
Body mass index (BMI) 0.2 0.6 4.2 2.0 0.3 -0.7 -0.8 0.2 1.4 0.2 0.4 0.1 -0.0 0.0 -0.0
Impedance of leg (left) 0.2 1.0 3.5 -0.2 0.3 0.8 -0.3 0.9 -1.9 1.1 -1.6 0.5 -1.0 0.3 -1.3
Leg predicted mass (left) 0.3 1.7 7.0 0.2 -0.7 -0.6 0.1 -1.3 0.8 -1.5 2.6 -0.5 1.4 -0.1 2.5
Trunk fat mass 0.1 0.5 4.1 2.0 -0.1 -0.8 -0.6 0.0 0.6 -0.1 0.8 0.1 0.1 0.2 0.4
Waist circumference 0.1 0.4 2.2 1.5 -0.1 -0.7 -0.3 -0.0 1.1 -0.1 0.7 0.2 -0.1 -0.1 0.1
Number of incorrect matches in round 0.4 0.7 4.0 0.4 -0.2 -1.3 -2.0 -0.3 1.3 -0.6 0.3 -0.1 0.3 0.3 0.7
Past tobacco smoking 1.4 2.5 8.5 -1.1 -0.7 -0.1 -1.9 -1.7 1.4 -1.7 2.3 -0.5 1.1 1.3 2.9
Alcohol usually taken with meals 0.6 0.9 2.3 -1.4 0.8 0.7 -0.8 1.2 -1.5 1.1 -0.4 0.7 -1.1 -0.1 -0.8
Nervous feelings 2.1 4.0 12.8 -3.6 -1.2 -1.5 -1.1 -2.1 1.1 -2.4 1.5 -2.4 2.0 -1.9 1.7
Frequency of tenseness / restlessness in last 2 weeks 2.0 3.1 8.2 -1.6 -1.5 -2.9 0.4 -1.7 0.6 -1.5 1.1 -2.5 2.1 -2.5 -0.2
Hearing difficulty/problems with background noise 0.7 1.2 3.3 0.3 -1.2 -1.3 -0.4 -0.8 -1.8 -0.3 0.5 -1.2 1.0 -1.6 -1.1
Hair/balding pattern: Pattern 2 0.3 0.4 2.0 -0.4 0.3 -0.6 -0.9 0.2 -1.4 0.4 0.1 1.0 -0.2 0.2 -0.8
Had menopause 0.7 0.9 4.5 0.3 0.7 2.1 -1.1 0.7 0.8 1.1 -0.6 0.5 -1.3 -0.3 -0.3
Had other major operations 1.3 1.6 5.4 -0.5 -1.4 -0.9 -0.4 0.3 -2.3 0.8 -1.3 -0.7 -0.0 -1.8 -2.2
Forced vital capacity (FVC) 0.7 2.6 4.8 -2.1 -1.2 -1.1 2.1 -1.7 -0.8 -2.2 1.7 -0.9 2.1 -0.7 1.6
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 3.7 -0.4 -0.8 0.1 -1.2 -0.8 -1.5 -0.7 1.9 -0.4 1.0 -0.5 1.5
Ever unenthusiastic/disinterested for a whole week 0.4 0.4 2.0 -0.8 -0.2 -1.1 -1.4 -0.2 0.4 -0.4 0.5 0.2 0.7 -0.3 0.4
Qualifications: None of the above 2.3 4.8 10.2 2.6 3.0 1.9 -0.1 2.3 -0.9 2.2 -2.0 3.2 -2.4 2.7 -0.7
Financial difficulties in last 2 years 2.4 3.3 10.0 -1.1 -2.0 -3.2 0.1 -1.7 -0.8 -1.4 1.0 -2.4 1.9 -2.9 -0.2
Mouth/teeth dental problems 0.7 1.1 3.5 -0.5 -1.1 -1.9 0.9 -1.0 -1.0 -1.1 0.9 -0.9 1.3 -1.0 -0.0
Heart attack 0.6 0.7 4.1 0.2 -0.7 0.1 -0.6 0.8 0.0 0.9 -0.7 0.8 -0.8 2.0 -0.8
Allergy 0.2 0.5 2.4 0.5 0.1 1.6 -0.7 0.3 -0.8 0.2 0.0 1.1 -0.7 0.9 0.1
Pain all over the body in last month 1.1 1.2 2.3 1.1 0.8 0.9 1.5 1.1 0.1 1.3 -1.1 0.8 -1.3 1.3 -1.2
Diabetes (self-reported) 2.7 4.2 13.2 2.7 0.8 -0.5 1.0 2.3 -0.5 2.3 -2.8 2.1 -2.0 0.8 -3.6
Hayfever/allergic rhinitis (self-reported) 0.3 0.5 1.6 -0.1 -0.3 -0.4 0.7 0.5 -1.3 0.8 -0.5 -0.9 -0.3 -0.4 -1.1
Medication: Ramipril 0.5 0.7 4.2 1.1 1.1 0.8 -0.4 0.1 2.0 0.2 0.1 0.2 -0.4 0.2 0.3
Medication: Simvastatin 1.9 2.7 5.4 1.5 1.8 1.7 -0.2 1.7 1.6 1.5 -1.4 2.0 -2.2 2.3 -0.4
Fluid intelligence score 0.5 1.1 5.0 -1.5 -0.2 -0.8 0.4 -0.0 -1.3 0.2 0.1 -1.8 0.3 -2.2 -0.6
Illnesses of siblings 9.1 12.7 22.1 -4.7 -3.3 -2.0 -0.9 -4.6 0.6 -4.5 4.7 -3.2 4.4 -2.0 4.2
Neuroticism score 0.5 1.1 3.2 -0.1 -1.1 -1.5 -0.4 -0.9 0.8 -0.9 0.5 -1.8 0.9 -1.8 -0.3
Weight 0.2 0.8 2.8 1.3 -0.7 -1.0 -0.2 -0.6 0.4 -0.7 1.7 -0.0 0.9 -0.2 1.1
Impedance of arm (right) 0.2 0.9 1.5 -0.6 -1.2 -1.1 -1.0 -0.9 -1.1 -0.8 0.5 -1.2 0.8 -1.2 -0.3
Arm fat percentage (right) 0.2 0.8 3.5 1.9 -0.3 -1.4 -1.2 -0.3 1.3 -0.3 0.9 -0.5 0.4 -0.4 0.1
Trunk fat-free mass 0.3 1.7 6.2 -0.5 -1.3 -0.8 0.4 -1.2 -0.4 -1.3 2.5 -0.3 1.6 -0.1 2.2
Hip circumference 0.1 0.5 4.0 2.0 -0.3 -1.0 0.2 0.2 0.4 0.1 0.5 -0.1 -0.0 0.1 -0.2
Time employed in main current job 1.2 1.4 5.1 0.5 0.6 1.3 -2.0 -0.6 0.4 -0.9 1.4 -1.1 0.7 -0.4 2.3
Alcohol intake versus 10 years previously 0.4 0.5 4.2 1.0 0.2 0.2 2.0 0.1 0.1 -0.4 0.2 -0.7 0.0 0.3 0.6
Father’s age at death 1.0 1.4 5.2 0.4 -1.2 -2.3 -1.5 -0.0 -1.4 0.3 -0.1 0.8 0.3 -0.9 -2.0
Worrier / anxious feelings 2.2 4.1 7.2 -1.2 -2.0 -2.1 -1.2 -2.4 2.6 -2.3 2.1 -2.7 2.1 -1.0 1.7
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 3.6 -1.1 -1.9 -0.7 -1.0 -0.8 -1.8 -0.6 0.6 -0.5 1.0 -0.3 0.6
Falls in the last year 0.7 0.9 2.3 1.5 0.7 0.8 0.6 1.0 0.6 1.4 -1.2 0.0 -1.0 0.5 -1.1
Hair/balding pattern: Pattern 3 1.3 2.0 3.8 -1.9 -0.3 -0.8 -0.3 -1.6 1.2 -1.5 1.7 -1.5 1.9 -1.5 1.4
Number of live births 3.6 5.1 12.7 -0.1 3.0 2.6 -1.3 2.6 -0.4 2.8 -3.1 1.7 -3.6 0.9 -1.5
Forced expiratory volume in 1-second (FEV1) 1.0 3.4 7.6 -1.7 -0.6 -0.1 2.4 -2.0 -0.2 -2.6 2.3 -1.7 2.1 -1.1 2.8
Pulse rate 4.5 7.7 30.4 2.8 1.7 -0.6 3.2 2.7 -0.4 3.2 -3.5 2.5 -2.2 0.3 -5.5
Happiness 0.3 0.4 1.7 -0.0 -0.1 -0.7 -0.3 0.6 -0.8 0.8 -0.8 0.1 -0.2 -0.1 -1.3
Noisy workplace 1.5 1.8 4.5 2.1 1.3 1.5 -0.8 1.2 -0.2 1.6 -1.3 1.3 -1.7 1.4 -0.5
Qualifications: A levels/AS levels or equivalent 0.5 1.2 3.5 -1.2 -1.5 -1.1 0.7 -1.3 -0.1 -0.9 0.7 -0.5 1.3 -1.9 -0.7
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 2.5 0.9 0.7 -0.3 0.1 1.3 0.3 1.2 -1.3 1.5 -0.4 1.1 -1.6
Mouth/teeth dental problems: Dentures 0.1 0.2 0.7 0.2 -0.2 0.3 -0.9 -0.5 0.7 -0.3 0.6 0.2 0.5 0.5 0.5
Asthma 0.1 0.2 0.8 0.9 -0.4 -0.4 0.2 0.3 0.0 0.1 -0.8 -0.4 0.3 -0.6 -0.4
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 4.6 -0.1 -0.3 0.0 -2.1 -0.4 0.8 -0.3 0.7 -0.5 0.3 0.1 0.7
Medication: Cholesterol lowering 0.2 0.3 0.8 0.7 -0.4 0.1 0.2 0.5 0.6 0.6 -0.4 0.9 -0.9 0.4 -0.4
Depression (self-reported) 1.2 1.4 2.9 -1.3 -1.7 -1.6 -1.5 -1.0 -1.1 -0.6 1.4 -0.4 1.7 -0.4 0.2
Medication: Lansoprazole 0.7 0.8 2.6 0.7 0.9 0.5 -1.1 0.8 0.1 0.7 -1.0 1.6 -1.0 0.3 -0.8
Prospective memory result 0.5 0.6 2.5 1.0 -0.8 -0.5 0.6 -0.7 0.3 -0.7 0.8 0.3 0.7 1.6 0.8
Lung cancer (father) 0.7 0.8 3.5 0.4 0.8 0.1 1.9 0.7 -0.1 0.5 -1.4 -0.1 -0.9 -0.0 -1.3
Illnesses of mother 2.3 2.9 5.6 -2.1 -1.9 -2.2 -1.5 -1.8 0.7 -1.6 1.8 -1.5 2.4 -1.1 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.6 9.4 -1.9 -0.6 0.3 3.0 -1.8 -0.7 -2.4 1.9 -1.7 2.0 -1.3 3.1
Pulse wave Arterial Stiffness index 0.2 0.3 1.7 -0.7 0.2 -0.2 0.2 -0.3 -1.3 -0.2 0.1 -0.6 -0.0 -0.8 0.2
Impedance of arm (left) 0.1 0.3 1.0 -0.5 -0.7 -0.6 0.1 -0.4 -1.0 -0.3 -0.1 -0.9 0.3 -0.7 -0.7
Arm fat mass (right) 0.2 0.7 3.1 1.8 -0.3 -1.0 -0.9 -0.2 1.0 -0.2 1.1 -0.2 0.4 -0.2 0.5
Trunk predicted mass 0.3 1.7 6.5 -0.5 -1.4 -0.8 0.4 -1.2 -0.5 -1.3 2.5 -0.3 1.6 -0.1 2.2
Standing height 0.4 3.9 9.7 -1.3 -2.7 -1.2 1.0 -2.0 -2.0 -2.3 3.1 -0.6 2.3 -0.7 2.5
Length of working week for main job 2.0 2.3 4.3 1.7 0.7 2.1 0.7 1.8 -0.9 1.8 -1.9 1.6 -1.9 0.3 -1.3
Exposure to tobacco smoke at home 1.3 1.5 4.0 1.1 0.6 -0.1 0.0 1.8 0.2 2.0 -2.0 0.4 -1.3 0.9 -1.6
Breastfed as a baby 2.5 3.1 7.4 0.5 2.6 2.7 0.6 2.0 -0.9 2.0 -1.2 1.4 -2.2 2.1 0.7
Tense / ‘highly strung’ 0.9 1.5 5.8 -1.1 -0.9 -1.8 -0.0 -1.2 -0.5 -1.1 0.4 -2.4 1.3 -1.6 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 1.2 -0.8 -1.1 -0.6 0.5 -0.3 0.5 -0.2 0.2 0.0 0.8 -0.3 -0.3
Hair/balding pattern: Pattern 4 0.2 0.5 1.2 1.0 -0.7 -0.1 -1.1 0.3 0.9 -0.0 -0.5 1.1 -0.3 1.1 -0.1
Birth weight of first child 2.6 4.7 8.8 -1.6 -1.7 -1.9 -2.1 -2.9 -0.6 -2.0 3.0 -2.4 2.6 -2.6 1.5
Peak expiratory flow (PEF) 0.6 1.4 4.1 -0.1 -0.4 0.5 2.0 -1.1 -0.5 -1.5 1.0 -1.4 1.2 -1.7 1.0
Pulse wave reflection index 2.6 3.2 8.4 -1.8 -0.9 -0.5 -2.3 -1.9 -0.9 -1.8 1.6 -2.9 1.5 -1.5 2.2
Ever highly irritable/argumentative for 2 days 1.0 1.2 3.3 -1.6 -0.8 -1.6 -1.1 -0.9 0.0 -1.1 0.4 -1.1 0.8 -1.8 0.3
Loud music exposure frequency 0.4 0.5 1.7 0.2 0.2 -1.2 0.5 -0.1 -0.6 -0.4 0.2 -1.1 0.4 -1.3 0.4
Qualifications: O levels/GCSEs or equivalent 2.6 4.2 7.2 -2.1 -2.7 -1.6 1.1 -2.4 1.1 -2.3 1.8 -2.6 2.3 -2.6 1.1
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.6 -0.8 -0.8 0.7 -0.1 0.5 0.0 0.4 -0.8 -0.2 -0.8 -0.6 -0.2
Blood clot in the leg (DVT) 0.2 0.2 1.2 -0.1 0.3 0.3 0.6 0.5 -0.1 0.6 -0.3 0.3 -0.4 1.1 -0.1
Medication: Paracetamol 1.0 1.6 4.3 -1.2 -2.1 -2.1 -0.4 -1.5 0.0 -1.3 1.0 -0.4 1.7 -0.8 0.3
Headache pain in last month 3.6 6.1 17.5 -2.1 -4.2 -3.5 -1.8 -2.6 -1.7 -1.9 2.0 -1.9 3.1 -2.3 0.4
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 2.8 -1.7 0.5 -0.4 -0.5 -0.8 0.4 -0.7 0.6 -1.3 1.1 -1.1 0.9
Glaucoma (self-reported) 0.7 0.8 2.0 -1.2 0.4 0.5 0.0 0.7 -0.5 0.6 -1.3 0.8 -1.0 -1.0 -1.4
Gout (self-reported) 0.9 1.3 4.8 0.6 0.3 0.6 -0.3 1.5 0.4 1.7 -1.7 0.7 -1.1 -0.3 -2.2
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.4 -0.9 -1.0 0.2 0.0 -0.8 -0.5 -0.8 1.2 -0.8 0.8 -0.7 0.7
Medication: Amlodipine 0.2 0.3 1.0 0.3 0.7 0.7 0.1 0.0 1.0 -0.3 -0.1 0.5 -0.1 0.9 0.2
Medication: Ventolin 100micrograms inhaler 0.5 0.6 5.6 0.4 -0.7 0.1 2.4 0.3 -0.2 -0.1 -1.0 0.2 -0.3 -0.5 -0.1
Birth weight 1.5 3.3 6.0 -1.2 -1.5 -0.5 -0.7 -2.1 1.3 -2.2 2.4 -2.3 2.1 -1.7 2.5
Chronic bronchitis/emphysema (mother) 0.7 0.9 3.8 0.4 -0.3 1.8 -0.7 -0.8 0.3 -0.6 0.5 0.2 -0.2 1.0 1.9
High blood pressure (siblings) 1.6 2.3 8.1 2.8 1.3 0.2 1.5 1.7 0.3 1.5 -2.0 0.4 -1.8 0.7 -1.7
Forced vital capacity (FVC), Best measure 0.8 3.1 6.2 -2.4 -1.4 -0.5 2.5 -1.6 -1.5 -2.2 1.4 -1.4 2.0 -1.2 2.1
Body fat percentage 0.2 0.6 5.2 2.3 0.3 -0.6 -0.7 0.3 1.1 0.3 0.2 -0.0 -0.2 0.2 -0.2
Leg fat percentage (right) 0.2 0.6 4.3 2.1 0.6 -0.7 -0.9 0.5 0.9 0.6 0.0 0.3 -0.2 0.1 -0.4
Arm fat-free mass (right) 0.1 0.5 2.8 0.2 -0.3 0.2 0.3 -0.2 -0.0 -0.4 1.3 0.4 0.4 0.4 1.7
Exposure to tobacco smoke outside home 0.2 0.3 1.7 0.1 -0.5 -1.3 0.7 -0.2 -0.6 0.0 0.1 0.0 0.2 -0.9 -0.5
Comparative body size at age 10 0.9 2.6 4.8 0.7 1.3 2.0 -1.4 2.2 -0.3 2.0 -1.8 1.6 -2.2 1.5 -1.3
Number of full brothers 1.5 1.9 3.8 0.4 1.1 0.7 -0.1 1.6 -1.8 1.4 -1.9 1.9 -1.4 0.5 -1.8
Worry too long after embarrassment 0.8 1.4 3.2 1.8 -1.1 -1.4 0.3 -1.1 1.6 -0.7 1.4 -1.2 1.3 -0.6 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.3 4.6 1.3 0.3 1.4 -0.7 1.7 -0.1 2.0 -2.1 1.5 -1.8 1.4 -2.0
Wheeze or whistling in the chest in last year 0.2 0.4 1.6 1.3 -0.0 0.2 -0.2 0.8 0.0 0.9 -1.0 0.3 -0.7 0.3 -0.6
Number of children fathered 1.6 1.8 4.2 1.2 2.1 1.4 1.1 1.2 1.0 1.3 -1.1 1.4 -1.3 1.8 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 4.5 0.2 -0.9 -1.8 2.1 0.0 -0.6 -0.1 -0.5 -1.0 0.3 -1.4 -1.5
Age at first live birth 0.7 1.2 2.4 -1.3 0.1 0.7 0.8 -1.1 1.6 -1.1 1.3 -1.3 0.7 -0.7 1.6
Pulse wave peak to peak time 0.2 0.3 1.5 0.6 -0.4 0.1 0.0 0.2 1.2 0.1 0.1 0.7 0.2 0.8 -0.1
Health satisfaction 1.1 1.4 4.3 1.6 0.6 -0.6 -0.7 1.4 -1.1 1.7 -1.3 -0.5 -0.7 0.4 -2.1
Shortness of breath walking on level ground 0.3 0.4 1.8 -0.0 0.6 0.2 0.5 -0.1 1.0 -0.6 0.5 -0.9 -0.2 -0.1 1.3
Qualifications: College or University degree 0.6 1.8 7.4 -2.7 -1.6 -1.0 -0.3 -1.1 -0.1 -0.9 0.8 -0.5 1.1 -2.3 -0.8
Eye problems/disorders: None of the above 1.3 1.5 3.6 -1.6 -1.2 -0.0 -1.5 -1.3 -0.5 -1.2 1.6 -0.9 1.2 0.1 1.9
Mouth/teeth dental problems: Loose teeth 0.3 0.4 2.8 1.7 -0.4 0.0 -1.1 0.1 0.6 -0.1 -0.0 -0.0 -0.3 -0.4 0.1
Emphysema/chronic bronchitis 0.5 0.6 1.8 1.3 1.4 0.2 0.7 0.4 1.1 0.5 -0.6 0.5 -0.8 -0.3 -0.6
Medication for pain relief, constipation, heartburn 0.7 1.2 4.0 -1.0 1.6 2.0 1.6 0.2 0.5 -0.1 0.2 -0.5 -0.5 -0.6 1.6
Neck or shoulder pain in last month 1.1 1.6 4.3 1.4 1.4 0.0 -0.3 1.7 -0.8 2.1 -1.7 0.8 -1.1 0.4 -1.4
Medication: Blood pressure 1.4 2.4 6.9 2.6 0.1 1.2 -0.1 1.4 -0.7 1.1 -1.2 2.5 -1.7 2.1 -1.4
Angina (self-reported) 0.8 1.1 3.1 0.7 0.1 -0.5 -1.4 1.4 -0.4 1.8 -0.8 0.8 -0.9 1.1 -1.4
Migraine (self-reported) 2.1 2.6 6.6 -2.6 -2.1 -2.4 0.4 -1.4 -2.0 -1.5 1.3 -0.5 1.5 -1.2 0.3
Medication: Ibuprofen 0.2 0.3 1.3 0.2 0.2 0.5 -1.1 -0.1 0.9 -0.1 0.4 -0.3 -0.2 0.4 0.8
Medication: Allopurinol 0.4 0.5 2.4 -0.2 -0.5 0.4 -1.6 0.6 0.4 0.8 -0.8 -0.1 -0.5 -0.8 -0.9
Medication: Omeprazole 0.4 0.4 1.7 -0.3 -0.8 -0.3 -1.2 -0.3 1.3 -0.4 0.3 0.3 -0.0 0.3 0.8
Medication: Seretide 50 evohaler 1.2 1.3 4.3 1.8 0.4 -0.6 1.1 1.1 -0.6 1.2 -1.4 0.2 -1.2 -0.3 -2.1
Mean time to correctly identify matches 0.8 1.6 4.5 2.1 -0.9 -0.6 -0.9 1.0 -0.4 1.2 -1.4 1.5 -1.3 0.3 -2.0
Heart disease (mother) 0.9 1.1 3.3 1.6 -0.3 -0.0 1.0 1.0 -1.4 0.9 -1.0 0.4 -1.1 -0.3 -1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 2.9 0.1 0.8 0.8 1.1 1.5 -0.4 1.4 -1.7 1.4 -1.5 1.2 -0.9
Whole body fat mass 0.1 0.6 4.0 2.0 0.0 -0.9 -0.5 -0.0 0.8 -0.1 0.8 0.1 0.2 0.1 0.4
Leg fat mass (right) 0.1 0.6 3.6 1.9 0.1 -0.8 -0.8 0.0 0.8 -0.0 0.8 0.2 0.3 -0.0 0.5
Arm predicted mass (right) 0.1 0.5 2.3 0.3 -0.4 0.1 0.3 -0.2 -0.3 -0.4 1.4 0.5 0.5 0.5 1.5
Pulse rate, automated reading 2.5 7.9 32.7 1.8 1.5 0.1 2.2 2.7 -2.3 3.5 -4.0 2.0 -2.5 -0.9 -5.7
Alcohol intake frequency. 0.3 0.6 1.5 0.5 -0.6 -1.2 -1.0 -0.5 -0.5 -0.4 1.2 0.5 1.0 0.8 0.8
Comparative height size at age 10 0.1 0.4 1.3 0.9 -0.0 0.0 0.2 0.4 -1.0 0.6 0.7 0.8 -0.2 1.2 0.7
Number of full sisters 1.2 1.5 3.4 0.4 0.1 0.9 1.0 1.5 -0.8 1.4 -1.8 1.0 -1.6 1.0 -1.8
Suffer from ‘nerves’ 2.2 3.4 7.6 -2.4 -1.9 -2.2 0.2 -2.0 -0.4 -1.6 1.2 -2.8 1.9 -2.7 0.1
Overall health rating 1.4 3.0 9.1 3.0 1.6 0.5 -0.4 2.0 0.2 2.3 -1.6 1.2 -1.6 2.2 -1.8
Chest pain or discomfort 0.6 0.9 2.4 1.0 -0.7 -1.4 0.9 0.2 -1.5 0.1 -0.7 -0.7 0.3 -0.9 -1.5
Had major operations 0.3 0.3 1.0 -0.3 -0.7 -0.8 0.2 -0.3 1.0 -0.3 0.0 -0.5 0.5 -0.5 -0.6
Age at last live birth 0.9 1.4 4.8 -2.2 0.1 0.2 0.7 -1.2 1.2 -1.4 0.9 -1.4 0.7 -1.2 1.2
Family relationship satisfaction 1.7 2.1 5.0 -1.4 -1.5 -2.2 -1.5 -1.4 -0.8 -1.2 1.1 -1.6 1.5 -1.7 0.3
Leg pain on walking 0.6 0.8 4.0 2.0 1.1 0.1 -0.3 0.8 0.8 1.2 -0.5 0.1 -0.5 0.8 -0.9
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.5 5.3 2.3 1.1 0.8 0.2 0.0 2.3 0.0 0.1 0.5 0.1 1.9 1.2
Commuting to job workplace: Car/motor vehicle 1.1 1.2 2.6 1.2 -0.4 -1.3 1.6 -1.2 1.4 -0.7 0.8 -0.7 1.4 -1.4 -0.4
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 5.7 0.1 1.6 2.4 -0.7 0.1 0.4 0.2 0.3 -0.0 -0.8 0.3 1.8
Medication: Aspirin 2.7 3.6 10.8 3.0 0.4 -0.1 0.4 2.0 -1.0 2.4 -2.2 1.7 -1.7 1.3 -3.3
Supplements: Vitamin C 0.5 0.6 2.6 -1.6 -0.7 -1.6 0.5 -0.6 0.3 -0.6 0.3 -0.8 0.7 -0.2 -0.1
Knee pain experienced in last month 0.4 0.6 1.7 1.0 -0.6 -1.0 -1.3 -0.1 -1.1 0.2 0.3 0.4 0.8 0.9 -0.1
Hypertension (Self-reported) 2.5 6.9 13.6 3.7 2.7 2.0 1.8 3.2 0.9 2.5 -2.7 2.9 -3.0 2.8 -2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 5.7 -0.5 -0.9 0.3 -2.4 -0.6 0.8 -0.6 0.6 0.1 0.3 1.2 0.8
Illnesses of father: Heart disease 0.4 0.5 2.7 -0.0 -0.6 -1.6 -0.5 0.1 -0.1 0.2 -0.0 -0.8 0.5 -1.3 -0.5
Illnesses of siblings: Diabetes 5.7 7.1 13.5 2.7 2.0 1.7 1.9 3.4 0.3 3.1 -3.7 2.6 -3.5 2.0 -2.9
Smoking status: Previous 1.5 2.2 5.8 1.6 1.5 0.1 1.5 1.7 -0.6 1.6 -2.1 1.0 -1.2 -0.7 -2.4
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.7 3.9 -0.2 -0.3 -0.6 2.0 -0.1 -1.5 -0.1 0.4 -0.7 0.9 -0.7 0.2
Whole body fat-free mass 0.3 1.6 6.5 -0.1 -1.1 -0.6 0.4 -1.2 0.2 -1.4 2.5 -0.4 1.5 -0.1 2.4
Leg fat-free mass (right) 0.3 1.8 6.6 0.3 -1.0 -0.7 0.3 -1.4 0.5 -1.6 2.6 -0.7 1.6 -0.4 2.3
Arm fat percentage (left) 0.2 0.7 4.6 2.1 0.3 -0.9 -0.6 0.2 1.2 0.2 0.3 -0.2 -0.1 0.0 -0.3
Average weekly red wine intake 0.7 1.1 3.8 -1.9 -0.4 -0.7 -0.7 0.9 -1.1 0.9 -1.2 0.6 -0.7 -0.4 -1.6
Handedness (chirality/laterality): Left-handed 0.3 0.4 1.3 -0.5 -0.6 -0.7 -0.4 0.6 -0.4 0.8 -0.8 -0.7 -0.4 -0.2 -1.1
Mood swings 0.8 1.4 6.3 -0.5 -0.7 -1.5 -0.3 -0.9 -0.7 -1.0 0.9 -2.5 1.2 -1.7 0.7
Loneliness, isolation 0.6 0.8 4.5 1.1 -1.1 -0.1 2.1 0.4 -1.2 0.3 -0.5 -0.4 -0.3 -0.3 -0.8
Long-standing illness, disability or infirmity 1.3 2.0 5.3 2.0 -1.0 -0.0 0.6 1.1 -2.3 1.2 -1.5 1.5 -1.1 0.8 -2.2
Ever had bowel cancer screening 1.5 1.8 7.6 2.8 0.3 0.2 -1.3 1.0 -0.8 1.0 -1.4 1.5 -1.3 0.9 -1.7
Diabetes diagnosed by doctor 2.6 4.2 17.8 2.7 0.1 -1.3 1.2 2.0 -1.3 2.3 -2.7 1.6 -1.5 -0.1 -4.2
Ever had stillbirth, spontaneous miscarriage or termination 0.9 0.9 4.3 1.0 -1.0 -0.6 2.1 -0.5 -0.9 -0.0 1.0 -1.0 0.7 -0.9 -0.6
Friendships satisfaction 0.7 0.9 4.8 0.6 -0.1 -1.0 0.2 0.8 -0.3 1.0 -0.7 0.9 -0.5 1.0 -2.2
Qualifications: nursing, teaching 0.5 0.8 5.3 -0.9 -0.1 0.2 -0.4 -0.7 2.3 -0.9 0.7 0.9 0.1 -0.6 0.7
Commuting to job workplace: Walk 0.6 0.6 5.2 0.3 -0.2 0.6 -2.3 0.3 -0.3 -0.1 0.5 0.5 -0.3 0.8 0.5
Eye problems/disorders: Cataract 0.6 0.7 2.5 1.5 1.3 -0.2 0.9 0.5 1.6 0.3 -0.4 0.5 -0.4 0.2 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.1 0.2 0.6 -0.5 -0.3 0.9 0.6 1.0 -1.1 0.3 -0.8 0.8 -0.4
Medication for cholesterol 0.6 1.0 2.0 -1.2 -1.1 0.2 -0.3 -1.1 -0.1 -1.1 1.2 -1.3 0.7 -0.8 1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 3.8 1.7 -0.7 -1.9 1.9 0.5 0.6 0.3 -0.6 -0.1 0.3 0.2 -2.0
Back pain experienced in last month 0.3 0.4 1.7 -1.0 -0.3 -0.1 -1.3 -0.4 -1.0 -0.0 0.4 0.5 0.4 -0.1 0.5
Mineral and other dietary supplements 0.3 0.3 1.1 -1.0 -0.1 -0.6 -0.5 -0.6 -0.2 -0.6 0.7 0.5 0.3 0.3 0.9
Breast cancer (self-reported) 1.3 1.5 4.2 -1.6 -1.8 -0.5 -1.8 -0.9 -0.6 -0.7 0.3 -1.6 0.8 -2.1 0.2
Asthma (self-reported) 0.1 0.3 1.4 1.2 -0.1 0.0 0.4 0.6 0.0 0.3 -1.1 0.0 -0.1 -0.3 -0.5
Osteoporosis (self-reported) 0.5 0.6 1.3 0.5 0.7 0.7 0.5 0.5 -0.1 0.6 -1.0 1.1 -1.0 1.0 -0.9
Osteoarthritis (self-reported) 1.6 2.1 3.5 1.4 0.3 1.2 -0.9 1.5 -1.3 1.8 -1.9 1.4 -1.7 1.6 -1.4
Medication: Aspirin 2.5 3.3 8.7 2.9 0.3 0.0 0.6 1.9 -0.5 2.2 -2.0 1.9 -1.7 1.8 -2.8
Medication: Gliclazide 1.5 1.8 4.8 1.0 -1.2 -0.8 0.6 1.0 -2.0 1.4 -1.8 -1.0 -0.8 -0.9 -2.2
Illnesses of father: None of the above (group 1) 0.7 0.9 3.5 -1.0 -0.4 0.6 0.1 -1.0 -0.7 -1.4 1.3 -0.3 0.7 -0.2 1.9
Smoking status: Current 0.2 0.3 2.2 0.0 -0.8 0.1 0.7 -0.3 -1.5 0.2 0.4 -0.0 0.2 -0.1 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.7 4.5 -1.6 -1.2 -0.9 1.4 -1.9 0.0 -2.1 1.4 -2.1 1.7 -2.1 1.9
Whole body water mass 0.2 1.4 5.7 0.1 -1.0 -0.5 0.4 -1.1 0.2 -1.2 2.4 -0.3 1.4 0.1 2.3
Leg predicted mass (right) 0.3 1.7 6.2 0.4 -0.9 -0.6 0.3 -1.3 0.6 -1.6 2.5 -0.6 1.5 -0.2 2.3
Arm fat mass (left) 0.1 0.6 3.1 1.8 -0.2 -1.1 -0.7 -0.1 1.0 -0.1 0.9 0.0 0.3 -0.0 0.2
Number of self-reported non-cancer illnesses 1.3 2.3 6.8 1.8 0.5 -0.2 1.2 1.6 -0.7 1.8 -1.6 2.1 -1.3 1.1 -2.6
Average weekly champagne plus white wine intake 0.4 0.6 2.1 -0.4 0.0 -0.2 0.5 1.0 -0.8 1.2 -0.4 0.8 -0.4 1.4 -0.5
Miserableness 0.1 0.3 0.8 -0.5 -0.8 -0.8 -0.9 0.3 -0.0 0.2 -0.0 -0.3 0.2 0.1 -0.6
Guilty feelings 0.5 0.7 2.6 0.8 -0.3 -1.4 -0.6 0.4 1.3 0.6 -0.8 -0.1 0.0 -0.6 -1.6
Wears glasses or contact lenses 0.2 0.2 1.3 -0.0 -1.1 0.3 -0.2 -0.2 0.2 -0.2 -0.2 0.9 -0.1 0.2 -0.7
Ever taken oral contraceptive pill 1.4 1.6 4.4 0.4 1.1 0.3 1.2 1.2 -1.5 0.9 -1.3 1.9 -0.7 1.0 -2.1
Hearing aid user 0.4 0.4 1.5 0.3 -0.8 -0.1 0.1 -0.5 -1.0 -0.7 0.5 -1.2 0.4 -0.6 0.4
Mother’s age at death 1.0 1.2 2.6 0.3 -1.4 -0.8 -0.1 -1.3 -1.6 -0.8 1.3 -1.1 1.2 -1.6 -0.3
Financial situation satisfaction 1.0 1.3 5.1 -2.3 -0.5 -1.5 -0.9 -0.4 -1.2 -0.6 -0.4 -1.0 0.2 -1.7 -0.6
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.3 -0.9 -1.0 -0.0 -1.1 -0.8 -0.8 -0.6 0.8 -0.3 0.6 -1.1 0.6
Commuting to job workplace: Public transport 0.2 0.2 0.8 -0.4 -0.9 -0.7 0.5 0.0 -0.7 -0.3 0.4 0.2 0.4 0.3 -0.3
Eye problems/disorders: Glaucoma 0.6 0.7 3.1 -1.8 0.3 0.4 0.2 0.4 0.2 0.1 -1.2 0.1 -0.8 -1.5 -0.9
Medication: Blood pressure 2.1 4.0 7.5 2.6 2.7 1.1 1.1 2.4 -0.0 2.4 -1.9 2.6 -1.9 1.9 -1.7
Pain type(s) experienced in last month: Hip pain 0.7 0.9 2.8 0.5 1.5 0.4 -1.7 1.1 -0.1 0.9 -0.7 0.5 -1.0 1.4 -0.1
Supplements: Fish oil (including cod liver oil) 0.2 0.3 1.7 0.1 -0.1 -0.4 0.3 -0.2 0.5 -0.2 -0.0 -1.3 0.3 -0.8 0.2
High cholesterol (Self-reported) 0.9 1.6 2.9 1.5 1.4 0.8 -0.3 1.4 1.6 1.3 -1.0 1.3 -1.5 1.7 -0.5
Medication: Bendroflumethiazide 1.3 2.0 11.8 3.4 0.9 0.8 1.0 0.8 -0.6 0.6 -0.5 2.1 -0.4 1.7 -0.8
Medication: Paracetamol 0.5 0.7 1.9 -0.9 -1.4 -1.3 0.1 -1.0 0.9 -0.9 0.6 -0.3 1.0 -0.6 0.1
Medication: Lisinopril 1.1 1.5 11.2 1.6 -0.3 0.3 3.3 0.7 -0.2 0.5 -0.3 1.1 -0.4 0.9 -0.9
Medication: Atorvastatin 0.3 0.4 1.3 0.1 -0.2 -1.0 0.9 0.7 0.3 0.8 -0.6 0.2 -0.1 0.3 -1.2
Illnesses of father: High blood pressure 0.5 0.7 2.3 1.5 -0.7 -0.9 0.5 -0.1 1.1 0.3 -0.6 -0.4 0.1 -0.0 -1.5
Alcohol drinker status: Never 1.3 1.5 7.3 -1.5 -1.4 -1.3 -2.7 -0.8 -0.7 -0.8 1.0 -0.9 0.7 -0.5 0.9
Ever smoked 1.5 2.7 7.7 0.3 0.5 -0.1 2.2 1.6 -1.8 1.8 -2.5 0.3 -1.4 -1.6 -2.8
Basal metabolic rate 0.3 1.5 6.2 0.3 -0.9 -0.7 0.2 -1.1 0.2 -1.3 2.5 -0.3 1.4 -0.1 2.3
Leg fat percentage (left) 0.2 0.7 5.2 2.3 0.7 -0.6 -0.7 0.6 0.7 0.8 -0.2 0.4 -0.4 0.1 -0.7
Arm fat-free mass (left) 0.2 0.9 3.6 0.1 -0.7 -0.2 -0.3 -0.8 0.0 -0.9 1.9 0.1 1.0 -0.0 1.9
Number of operations (self-reported) 1.1 1.6 8.2 0.8 -0.7 -1.6 0.6 1.0 -1.1 1.5 -1.4 0.5 -0.3 -0.1 -2.9
Average weekly beer plus cider intake 0.2 0.3 1.4 -0.2 0.3 0.3 0.0 -0.8 0.6 -0.8 0.4 0.2 0.5 0.5 1.2
Irritability 0.3 0.4 1.9 -0.2 -0.6 -0.3 -1.1 -0.2 -0.7 -0.1 0.0 -1.4 0.4 -1.0 0.1
Risk taking 0.5 0.7 7.1 -0.2 -0.4 0.0 2.7 -0.1 -0.2 0.2 -0.2 -0.1 0.3 0.8 0.3
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.4 -0.2 -1.1 -1.2 0.5 -0.4 -0.5 -0.5 0.5 0.6 0.4 -0.4 -0.3
Fractured/broken bones in last 5 years 1.2 1.5 2.9 -0.2 1.3 0.9 -1.2 1.4 1.6 1.5 -1.7 0.3 -1.6 1.2 -0.7
Age started oral contraceptive pill 0.9 1.1 2.2 -0.8 -0.9 0.1 -1.1 -1.3 0.6 -1.4 0.9 -0.8 0.9 -1.5 1.3
Diastolic blood pressure, automated reading 1.3 3.9 12.4 3.5 1.9 0.3 1.9 2.5 -0.4 2.1 -2.1 1.5 -1.9 0.8 -2.6
Ever depressed for a whole week 0.9 1.1 2.8 -1.2 -0.5 -1.6 -1.7 -0.7 -0.6 -0.9 1.2 -0.7 1.3 -0.6 0.6
Unable to work because of sickness or disability 1.4 1.8 5.3 2.3 1.1 0.7 0.6 1.1 1.6 1.2 -0.9 1.5 -0.8 1.8 -1.3
Commuting to job workplace: Cycle 0.5 0.6 2.3 -0.3 -0.7 -0.0 -1.5 -0.7 -0.5 -0.6 1.1 -0.2 0.6 -0.3 1.3
Myopia 0.4 0.6 2.6 -0.7 0.3 0.8 -0.4 -0.8 0.6 -0.4 0.7 -0.6 0.5 0.7 1.6
Vascular/heart problems diagnosed by doctor 1.9 5.3 9.0 -3.0 -1.7 -1.7 -0.8 -2.9 0.1 -2.5 2.5 -2.8 2.8 -2.4 2.3
Cholesterol lowering medication 2.1 3.2 5.5 1.8 1.7 1.0 0.6 2.1 0.7 2.1 -2.4 1.7 -2.3 1.9 -1.9
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 1.2 -0.3 -0.7 -0.7 -0.7 -0.2 1.1 -0.4 0.2 0.4 0.1 0.5 0.4
Pain experienced in last month 0.6 0.9 3.2 -0.9 -0.1 0.7 0.7 -0.9 1.8 -1.4 0.5 -1.1 0.3 -0.6 1.1
Supplements: Calcium 0.6 0.7 3.0 -0.2 -0.4 0.3 -0.6 0.5 0.3 0.6 -1.7 -0.2 -1.0 0.2 -1.6
Basal cell carcinoma (self-reported) 0.3 0.3 0.9 0.0 0.8 0.4 -0.8 -0.0 0.9 0.2 0.4 -0.9 -0.0 0.3 0.6
Heart attack/myocardial infarction (self-reported) 0.7 0.9 5.5 0.4 -0.5 0.3 -0.5 0.9 0.2 1.1 -0.8 0.9 -1.0 2.3 -0.7
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.8 -0.3 0.2 0.1 0.3 0.2 0.1 0.4 0.1 -0.0 -0.0 0.9 0.1
Heart disease (siblings) 2.3 2.8 7.5 2.7 1.7 1.2 -1.3 1.8 0.5 1.8 -1.5 2.4 -1.8 0.6 -1.1
Alcohol drinker status: Previous 1.3 1.5 2.6 0.6 1.6 1.3 0.7 1.1 0.9 1.2 -1.5 1.6 -1.4 1.5 -0.7
Pack years of smoking 1.1 1.6 5.9 1.8 0.9 1.0 0.2 0.8 0.8 0.8 -0.6 1.8 -1.4 2.4 0.1
Impedance of whole body 0.1 0.4 2.3 -0.7 -0.3 0.2 -0.3 0.1 -1.5 0.1 -0.7 -0.5 -0.3 -0.4 -0.7
Leg fat mass (left) 0.1 0.5 3.8 2.0 0.1 -0.8 -0.7 0.1 0.7 0.0 0.7 0.2 0.2 -0.1 0.3
Arm predicted mass (left) 0.2 0.8 3.7 0.1 -0.6 -0.1 -0.4 -0.6 0.2 -0.8 1.8 0.1 0.9 0.2 1.9