Hub : Genes

SMC6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0610	0.0230	1.1e-03	0.035	0.028	0.033	0.03	0.023	3.4e-05	1.8e-04	6.6e-05	0.00012	8.0e-04
2	GTEx	Cells Transformed fibroblasts	0.2570	0.0630	2.4e-07	0.112	NA	0.068	NA	0.037	9.4e-09	NA	7.6e-06	NA	8.3e-04
3	GTEx	Esophagus Mucosa	0.1660	0.0540	4.2e-04	0.010	NA	0.039	NA	0.011	6.8e-02	NA	1.3e-03	NA	5.8e-02
4	GTEx	Esophagus Muscularis	0.2000	0.0690	2.8e-03	0.069	NA	0.009	NA	0.051	5.3e-05	NA	8.8e-02	NA	4.4e-04
5	GTEx	Liver	0.2470	0.0800	2.4e-04	0.227	NA	0.138	NA	0.207	5.7e-07	NA	1.1e-04	NA	1.9e-06
6	GTEx	Skin Not Sun Exposed Suprapubic	0.2020	0.0710	1.7e-03	0.021	NA	0.058	NA	0.060	2.5e-02	NA	4.2e-04	NA	3.3e-04
7	GTEx	Small Intestine Terminal Ileum	0.2880	0.1060	5.6e-03	0.129	NA	0.005	NA	0.030	8.3e-04	NA	2.4e-01	NA	7.4e-02
8	GTEx	Thyroid	0.0980	0.0320	3.3e-05	0.108	NA	0.103	NA	0.110	1.3e-08	NA	2.7e-08	NA	9.2e-09
9	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0890	0.0540	4.6e-03	0.043	0.043	0.022	NA	0.045	1.6e-03	1.8e-03	1.9e-02	NA	1.4e-03
10	TCGA	Brain Lower Grade Glioma	0.0734	0.0309	1.1e-08	0.099	0.080	0.074	NA	0.044	2.5e-11	2.2e-09	8.0e-09	NA	8.3e-06
11	TCGA	Prostate Adenocarcinoma	0.0776	0.0398	7.6e-05	0.020	0.050	0.055	NA	0.028	3.5e-03	5.6e-06	1.8e-06	NA	6.1e-04
12	TCGA	Thyroid Carcinoma	0.0300	0.0170	2.8e-03	0.025	0.025	-0.001	NA	0.013	1.6e-03	1.5e-03	3.9e-01	NA	1.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.6	1.0	5.3	0.3	-0.8	-1.1	-1.2	-0.4	-2.3	0.1	0.3	-0.7	0.7	-1.1	-0.7
Bipolar Disorder or Schizophrenia	0.8	1.9	5.2	2.3	0.2	-0.1	-0.5	1.2	-1.2	1.6	-1.6	1.1	-1.1	1.1	-2.3
Depressed Affect (Nagel 2018)	0.6	1.3	3.7	-0.6	-1.5	-1.4	1.0	-0.8	0.7	-1.1	0.8	-1.9	1.5	-1.2	0.5
Depression (Nagel 2018)	0.3	0.4	1.2	-0.6	-0.6	-1.0	-0.1	-0.4	0.8	-0.3	0.7	-0.1	1.1	1.0	-0.2
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.1	-1.5	0.5	0.3	-1.1	0.6	-0.5	1.0	-0.6	-0.4	-0.5	-0.7	-0.9
Neuroticism (Nagel 2018)	1.4	3.2	7.4	-1.0	-1.9	-2.2	-0.3	-1.8	1.6	-2.0	1.5	-2.7	2.3	-1.8	1.1
Schizophrenia (2018)	1.7	3.5	7.7	2.8	1.3	0.8	0.4	1.9	0.3	2.0	-2.3	2.0	-2.0	2.3	-2.3
Schizophrenia vs Biploar Disorder	0.9	1.2	5.6	2.0	-0.1	-0.1	2.4	0.6	1.2	0.4	-1.0	0.6	-0.8	0.4	-1.0
Worry (Nagel 2018)	2.2	4.7	10.8	-2.1	-1.8	-2.0	-0.3	-2.5	1.2	-2.6	2.0	-3.3	2.6	-2.5	1.5
Alzheimer’s Disease (in mother)	0.4	0.4	1.4	0.9	-0.2	-0.9	-0.0	0.2	-0.2	0.0	-0.8	-0.0	-0.2	-1.2	-1.0
Alzheimer’s Disease (in father)	0.6	0.6	2.6	0.2	0.6	0.8	1.6	0.8	1.2	1.0	-0.7	-0.2	-0.6	0.2	-0.5
Alzheimer’s Disease (including proxy)	0.3	0.5	2.5	-0.0	-0.4	-1.1	0.6	-0.4	0.5	-0.3	-0.1	-0.7	0.4	-1.6	-0.5
Crohns Disease (2017)	0.4	0.8	2.1	0.5	-1.4	-0.9	-1.4	-0.6	-1.1	-0.5	0.5	-0.2	1.1	-1.0	0.0
Irritable Bowel Disease (IBD)	0.2	0.4	1.4	1.2	-1.1	-0.3	-0.5	-0.4	-0.6	-0.4	0.0	0.6	0.5	0.0	0.3
Ulcerative Colitis (UC)	0.3	0.6	2.8	1.7	-0.5	0.6	0.5	0.2	-0.3	0.2	-0.8	1.2	-0.5	1.1	-0.0
Major Depression (MDD)	0.2	0.2	0.8	0.1	-0.2	-0.2	0.4	0.2	-0.9	0.2	-0.2	0.7	0.2	0.9	-0.3
Reaction Time	1.2	2.3	7.0	2.2	-0.4	-0.5	-0.2	1.6	-1.1	1.7	-1.8	1.7	-1.5	0.7	-2.6
Verbal and Numeric Reasoning (VNR)	0.4	0.9	3.8	-1.7	-0.5	-0.4	0.4	-0.4	0.0	-0.0	0.4	-1.8	0.3	-2.0	-0.3
Breast Cancer	0.5	1.3	2.9	1.3	1.0	1.4	-1.5	1.1	-0.5	1.4	-1.0	-0.1	-1.7	1.2	0.3
Ovarian Cancer	0.4	0.5	1.2	0.1	-0.3	1.1	0.0	0.7	-1.0	0.7	-0.6	0.9	-1.0	0.9	-0.1
Prostate Cancer	6.2	8.7	13.1	3.5	3.1	2.3	2.8	3.6	0.3	3.4	-2.9	3.0	-3.2	3.6	-2.0
Age at First Birth	0.5	0.8	2.5	-0.4	-1.2	-0.8	-0.7	-0.7	0.6	-0.8	0.9	-1.6	1.0	-0.1	0.7
Bipolar Disorder (2011)	0.2	0.2	0.4	0.3	-0.4	-0.6	0.1	0.1	-0.4	0.4	-0.2	-0.4	0.0	-0.6	-0.6
Body Mass Index (BMI) (2010)	0.2	0.3	1.5	1.2	0.2	0.0	-0.2	0.3	-1.0	-0.0	-0.2	0.2	-0.4	-0.5	-0.1
Coronary Artery Disease (CAD)	0.9	1.1	3.7	-0.2	1.0	1.9	-1.6	0.4	1.2	-0.1	-0.5	0.1	-1.4	0.8	1.1
Crohns Disease (2012)	0.8	1.3	2.5	-0.6	-0.6	-0.7	-1.2	-1.3	0.1	-1.2	1.4	-1.6	1.3	-1.6	0.9
Mean Putamen Volume	0.3	0.3	1.3	0.4	-0.0	0.4	-0.7	-0.6	-0.6	-0.4	0.0	-0.9	0.3	-1.2	0.1
Fasting Glucose	0.6	0.7	2.8	1.3	1.2	0.4	0.2	0.2	-1.0	0.4	-0.6	-0.4	-0.0	-1.7	-0.5
HbA1C	0.4	0.4	1.9	0.8	-0.7	0.5	-0.2	0.0	-1.4	0.3	0.3	1.1	-0.2	-0.1	-0.7
HDL Cholesterol	1.0	1.6	6.0	0.1	1.6	2.4	0.1	1.3	0.9	1.2	-1.1	1.1	-1.8	0.9	0.1
LDL Cholesterol	0.8	1.3	6.2	0.4	1.4	2.5	0.4	0.4	1.1	0.3	-0.1	0.3	-1.0	0.9	1.9
Lupus	2.6	3.9	15.4	-0.6	-1.3	-2.1	1.1	-2.1	1.2	-1.7	1.9	-3.9	2.0	-1.9	1.8
Neuroticism (2016)	0.2	0.3	1.5	-0.3	-0.4	0.7	-1.2	0.1	0.3	0.1	-0.6	-0.4	-0.2	-0.5	-0.4
Primary Biliary Cirrhosis	0.4	0.6	2.5	0.5	0.3	1.6	-1.3	0.7	-0.4	0.8	-0.5	0.1	-0.4	0.5	-0.5
Rheumatoid Arthritis	0.8	1.1	6.0	-0.3	0.1	-0.4	-2.4	-1.1	0.0	-1.3	1.5	0.3	1.1	-0.3	0.6
Schizophrenia (2014)	2.4	5.2	9.3	2.6	1.7	0.8	0.1	2.5	0.6	2.7	-2.9	2.6	-2.4	2.9	-3.0
Triglycerides	0.1	0.2	0.8	0.9	0.2	-0.2	-0.4	-0.2	-0.3	-0.1	0.4	-0.0	0.4	0.0	0.7
Type 2 Diabetes (T2D) (2012)	1.3	1.5	3.7	-1.0	-1.7	-1.9	-0.2	-0.9	-1.8	-0.7	0.6	-0.6	1.4	-1.5	-0.5
Ulcerative Colitis	0.3	0.4	1.4	0.8	-0.2	0.6	-1.2	-0.4	0.4	-0.3	-0.1	0.1	-0.2	0.8	0.9
Blood Eosinophil Count	0.1	1.1	2.8	-1.0	-1.5	-1.7	-0.5	-1.0	-0.1	-1.1	0.9	-1.0	1.2	-1.0	0.3
Blood Platelet Count	0.1	0.6	2.1	0.6	0.7	1.4	0.5	-0.2	1.2	0.1	-0.2	-0.8	-0.1	0.5	1.2
Blood Red Count	0.1	1.0	3.3	0.2	0.2	1.3	-0.5	-0.2	0.9	-0.8	1.5	1.1	0.1	1.3	1.8
Blood White Count	0.2	1.2	4.8	0.2	-1.3	0.1	0.2	-1.4	-0.2	-1.0	1.8	-0.5	1.2	-0.3	2.2
Heel T-Score	0.1	0.8	3.6	0.4	-0.0	1.9	-0.7	-0.1	-0.4	0.1	0.2	1.8	-0.3	1.1	0.8
BMI	0.1	0.7	5.2	2.3	0.0	-0.8	-0.3	0.2	0.5	0.1	0.8	0.2	0.4	1.0	0.2
Height	0.2	3.6	16.4	-1.9	-2.2	0.6	-1.1	-1.5	-0.8	-2.3	2.7	0.2	1.0	0.3	4.0
Waist Hip Ratio (WHR)	0.1	0.5	0.9	-0.8	0.9	0.9	0.4	0.8	0.9	0.7	-0.4	0.6	-0.8	0.8	0.2
Systolic Blood Pressure	1.4	7.0	13.9	3.2	3.7	2.1	1.9	3.1	0.0	2.4	-2.0	3.7	-2.9	2.7	-1.9
Smoking Status	1.1	2.7	14.0	1.6	0.1	0.3	3.7	1.3	-1.7	1.8	-1.6	0.1	-0.9	-0.6	-2.0
Allergy or Eczema	0.3	0.8	4.2	-0.3	-0.8	-2.0	-0.2	-0.8	0.2	-0.4	0.6	-0.5	1.2	-1.1	-0.3
Cardiovascular Disease	1.6	5.3	8.0	2.4	2.8	2.7	1.2	2.8	1.2	2.1	-2.2	2.7	-2.7	2.8	-1.0
Hypothyroidism (self reported)	0.3	0.6	1.3	-1.1	-0.7	-0.3	1.1	-0.5	-0.9	-0.6	1.1	-0.6	0.8	-0.8	0.3
Respiratory disease	0.1	0.2	0.4	0.7	0.2	0.3	0.2	0.5	0.4	0.3	-0.6	0.6	-0.2	-0.2	0.0
Type 2 Diabetes (T2D) (2018)	3.4	6.3	19.2	2.9	1.3	0.0	2.4	2.8	-0.9	2.9	-3.4	2.5	-2.4	0.9	-4.4
Lung FEV1/FVC ratio	1.1	5.4	15.6	2.9	0.5	2.7	3.1	-1.9	0.6	-1.8	3.0	-2.1	1.6	-0.7	4.0
Lung FVC	0.4	2.1	5.1	-1.9	-0.7	-0.8	2.3	-1.6	-0.1	-2.1	0.6	-1.5	1.4	-1.9	0.7
Neuroticism	0.5	1.3	3.8	0.0	-1.4	-2.0	0.1	-0.7	1.4	-0.9	0.4	-1.4	1.2	-1.5	-0.6
Chronotype (morning person)	1.4	3.2	9.5	-1.8	1.2	0.5	-1.9	-1.4	2.8	-2.1	1.9	-0.5	1.2	0.6	3.1
Hair Pigment	0.1	1.5	3.4	-0.2	-1.2	-0.5	-1.2	-1.0	1.9	-0.9	1.1	-1.8	0.9	-1.5	1.3
Tanning	0.1	0.8	2.0	0.2	-0.5	0.6	-1.3	-1.0	0.9	-1.0	0.6	0.1	0.5	1.4	1.4
Hand grip strength (left)	1.9	5.0	11.4	-2.5	-1.8	0.0	-0.7	-2.7	-0.7	-3.0	3.1	-1.5	2.7	-1.5	3.4
Number of treatments/medications taken	0.4	0.6	1.7	1.3	-0.9	-0.6	0.6	0.5	-0.1	0.4	-0.7	1.2	-0.4	0.7	-1.2
Average weekly spirits intake	0.9	1.1	2.7	0.9	1.0	1.4	1.6	0.7	1.2	0.8	-1.1	0.8	-1.2	1.3	-0.2
Sensitivity / hurt feelings	1.3	2.2	5.2	0.3	-1.4	-2.2	-2.0	-1.5	0.4	-1.8	1.0	-1.6	1.1	-2.3	0.1
Frequency of depressed mood in last 2 weeks	0.9	1.3	4.9	-1.3	-0.8	-2.2	-0.6	-1.1	0.3	-1.0	0.9	-1.5	1.6	-0.2	-0.0
Hearing difficulty/problems: Yes	1.3	2.1	4.7	2.2	0.9	0.9	-0.3	1.7	-1.8	2.1	-1.6	0.1	-1.3	0.5	-1.8
Relative age of first facial hair	1.2	2.5	5.8	-2.4	-2.1	-0.8	-2.3	-1.9	-0.2	-1.6	1.1	-1.5	1.4	-1.4	1.0
Other serious medical condition/disability diagnosed by doctor	2.7	3.5	7.1	1.4	1.5	1.0	1.1	2.7	-1.6	2.4	-2.5	1.1	-2.5	1.5	-2.1
Ever used hormone-replacement therapy (HRT)	1.1	1.4	8.3	0.3	-0.2	-0.4	-0.9	0.7	-0.5	1.1	-1.6	1.4	-0.9	-0.3	-2.9
Ever had hysterectomy (womb removed)	1.1	1.3	2.8	-0.2	1.7	-0.2	-0.7	1.5	-1.0	1.4	-1.2	1.2	-1.0	0.8	-1.4
Systolic blood pressure, automated reading	1.8	5.4	10.0	3.1	3.2	1.6	1.3	2.7	1.4	2.3	-2.0	2.6	-2.8	2.0	-1.8
Eye problems/disorders: Diabetes related eye disease	4.2	4.6	14.3	1.8	0.2	0.4	0.7	2.3	-2.3	2.2	-2.6	2.8	-2.1	1.3	-3.8
Angina	0.7	0.9	2.6	0.7	0.1	-0.5	-1.5	1.2	-0.3	1.6	-0.7	0.4	-0.8	0.7	-1.3
Medication for hormone replacement therapy	2.6	2.9	6.4	-1.4	-1.5	-2.5	-1.5	-1.8	0.6	-1.7	1.4	-1.9	2.3	-2.0	0.3
Vitamin and mineral supplements	2.0	2.7	7.1	1.1	2.0	2.2	0.1	1.5	0.5	1.7	-1.0	2.6	-1.3	2.7	-0.4
Supplements: Zinc	0.6	0.7	2.3	0.6	-1.5	-0.7	0.6	-0.7	-1.1	-0.5	0.8	-0.6	0.9	-1.0	-0.1
Medication: Co-codamol	0.1	0.2	0.4	0.1	-0.4	-0.5	-0.6	-0.4	-0.4	-0.2	0.1	0.5	0.3	-0.1	-0.5
Medication: Metformin	1.9	2.7	11.6	1.5	-0.3	-1.2	0.6	1.5	-1.2	1.6	-2.5	1.5	-1.3	-0.4	-3.4
Diabetes (father)	4.0	5.0	14.7	2.6	2.6	2.3	1.4	2.2	-0.7	2.0	-1.2	3.8	-1.9	2.7	-1.6
Diabetes (mother)	0.8	1.0	2.6	0.4	0.9	1.2	0.9	1.0	-0.8	0.7	-1.6	1.3	-1.4	0.5	-0.9
Severe depression (siblings)	0.9	1.0	3.9	-0.1	-0.4	-0.4	2.0	-0.0	-1.1	-0.3	-0.5	-1.3	0.6	-1.9	-0.0
Pack years adult smoking proportion	0.6	0.9	4.3	1.5	0.6	0.7	-0.1	0.5	0.4	0.5	-0.2	1.4	-0.9	2.1	0.3
Impedance of leg (right)	0.1	0.7	2.1	-0.7	0.5	0.8	-0.3	0.8	-1.4	0.9	-1.2	0.5	-0.9	0.5	-0.8
Leg fat-free mass (left)	0.3	1.9	7.2	0.2	-0.7	-0.6	0.1	-1.3	0.8	-1.6	2.7	-0.6	1.5	-0.2	2.6
Trunk fat percentage	0.1	0.5	4.5	2.1	0.2	-0.5	-0.8	0.2	0.9	0.1	0.4	0.0	-0.2	0.2	0.1
Hand grip strength (right)	1.4	3.8	10.4	-1.2	-1.3	-0.2	0.3	-2.4	-0.5	-2.6	3.2	-1.2	2.6	-1.1	3.2
Townsend deprivation index at recruitment	0.1	0.2	0.5	0.3	0.5	-0.6	0.7	-0.2	-0.4	-0.1	0.3	0.0	0.4	0.4	0.2
Current tobacco smoking	0.1	0.2	1.4	0.0	-0.6	0.0	0.4	-0.3	-1.2	0.2	0.4	0.1	0.1	0.3	0.3
Average weekly fortified wine intake	3.1	3.6	6.2	1.2	2.5	2.2	2.2	2.1	0.8	1.9	-2.0	1.9	-2.5	1.5	-1.2
Maternal smoking around birth	1.1	1.5	7.2	1.1	-2.7	-1.1	-0.8	-1.5	0.3	-1.4	1.0	-0.6	1.6	-0.3	0.1
Fed-up feelings	0.5	0.8	3.0	-1.1	-0.8	-0.7	0.3	-0.7	1.2	-0.9	0.2	-1.7	0.6	-0.9	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	1.7	-0.5	-1.3	-0.6	-0.3	-0.4	-0.7	-0.1	0.5	-0.2	0.8	0.1	-0.3
Relative age voice broke	0.4	0.6	3.6	-1.9	-0.8	1.0	-0.5	-0.6	-0.1	-0.7	-0.1	-0.4	-0.3	-0.6	0.6
Taking other prescription medications	2.1	3.3	8.1	2.5	-0.7	0.3	0.0	1.9	-2.1	2.2	-2.1	1.7	-1.9	1.2	-2.8
Age when periods started (menarche)	3.0	7.2	12.6	-2.7	-2.5	-1.1	0.3	-3.3	0.5	-3.4	3.4	-3.1	3.1	-2.5	3.5
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	8.6	0.2	-0.1	-0.2	-1.0	1.2	-1.0	1.0	-2.3	0.6	-1.0	-0.7	-2.9
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	3.1	-0.3	-1.2	0.6	-1.7	-1.1	-0.9	-1.3	1.8	0.0	0.8	-0.6	1.6
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	2.0	-0.8	-0.7	-1.4	0.1	-0.8	-0.4	-0.9	0.1	-1.4	0.9	-0.8	-0.3
Qualifications: CSEs or equivalent	0.9	1.1	2.0	1.3	1.4	1.4	-0.1	1.0	-0.9	1.1	-1.1	0.7	-1.3	1.1	-0.4
Serious illness, injury or assault to yourself	3.9	4.7	16.4	2.5	0.4	-0.8	0.6	2.9	0.0	3.1	-2.9	1.5	-1.7	1.4	-4.0
High blood pressure	2.2	6.2	12.7	3.6	2.2	1.6	1.5	3.0	0.2	2.5	-2.8	3.0	-2.9	2.5	-2.5
Hayfever, allergic rhinitis or eczema	0.5	1.0	4.3	-1.2	-0.8	-2.1	0.8	-0.1	-0.2	0.2	-0.3	-1.1	0.8	-1.4	-1.0
Multivitamins +/- minerals	0.9	1.2	4.9	0.1	-1.0	-1.3	-0.4	-0.9	-0.1	-0.8	0.8	-1.9	0.8	-2.2	0.3
Stomach or abdominal pain in last month	0.7	0.9	3.8	0.6	-1.0	-1.9	0.7	0.1	-0.0	0.1	-0.6	0.0	0.6	-0.5	-1.9
Supplements: Glucosamine	0.2	0.2	1.1	0.8	-0.3	0.1	-0.2	-0.3	-0.1	-0.1	0.4	-0.5	0.5	-1.0	-0.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.9	0.2	-0.7	-1.4	0.2	-0.1	-0.3	-0.7	-0.1	-1.0	0.3	-0.8	-0.5
Medication: Atenolol	0.4	0.5	2.2	1.1	-0.2	0.0	0.7	0.2	-0.7	-0.0	-0.2	1.5	-0.3	0.4	-0.8
Medication: Levothyroxine sodium	0.2	0.3	1.3	-0.3	-0.2	1.2	0.2	-0.2	-0.9	-0.2	0.3	-0.5	-0.1	0.3	0.5
Sitting height	0.3	2.0	12.9	0.9	-1.5	-0.2	1.3	0.9	-3.6	0.8	-0.3	1.5	-0.2	0.7	-1.2
Chronic bronchitis/emphysema (father)	0.2	0.3	1.3	0.7	0.9	-1.1	0.1	-0.1	0.2	0.4	0.1	0.2	0.2	0.3	-0.4
High blood pressure (mother)	1.5	2.1	7.5	1.1	2.7	1.8	1.1	1.4	1.2	1.2	-0.7	1.6	-1.4	1.2	-0.8
Body mass index (BMI)	0.2	0.6	4.2	2.0	0.3	-0.7	-0.8	0.2	1.4	0.2	0.4	0.1	-0.0	0.0	-0.0
Impedance of leg (left)	0.2	1.0	3.5	-0.2	0.3	0.8	-0.3	0.9	-1.9	1.1	-1.6	0.5	-1.0	0.3	-1.3
Leg predicted mass (left)	0.3	1.7	7.0	0.2	-0.7	-0.6	0.1	-1.3	0.8	-1.5	2.6	-0.5	1.4	-0.1	2.5
Trunk fat mass	0.1	0.5	4.1	2.0	-0.1	-0.8	-0.6	0.0	0.6	-0.1	0.8	0.1	0.1	0.2	0.4
Waist circumference	0.1	0.4	2.2	1.5	-0.1	-0.7	-0.3	-0.0	1.1	-0.1	0.7	0.2	-0.1	-0.1	0.1
Number of incorrect matches in round	0.4	0.7	4.0	0.4	-0.2	-1.3	-2.0	-0.3	1.3	-0.6	0.3	-0.1	0.3	0.3	0.7
Past tobacco smoking	1.4	2.5	8.5	-1.1	-0.7	-0.1	-1.9	-1.7	1.4	-1.7	2.3	-0.5	1.1	1.3	2.9
Alcohol usually taken with meals	0.6	0.9	2.3	-1.4	0.8	0.7	-0.8	1.2	-1.5	1.1	-0.4	0.7	-1.1	-0.1	-0.8
Nervous feelings	2.1	4.0	12.8	-3.6	-1.2	-1.5	-1.1	-2.1	1.1	-2.4	1.5	-2.4	2.0	-1.9	1.7
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	8.2	-1.6	-1.5	-2.9	0.4	-1.7	0.6	-1.5	1.1	-2.5	2.1	-2.5	-0.2
Hearing difficulty/problems with background noise	0.7	1.2	3.3	0.3	-1.2	-1.3	-0.4	-0.8	-1.8	-0.3	0.5	-1.2	1.0	-1.6	-1.1
Hair/balding pattern: Pattern 2	0.3	0.4	2.0	-0.4	0.3	-0.6	-0.9	0.2	-1.4	0.4	0.1	1.0	-0.2	0.2	-0.8
Had menopause	0.7	0.9	4.5	0.3	0.7	2.1	-1.1	0.7	0.8	1.1	-0.6	0.5	-1.3	-0.3	-0.3
Had other major operations	1.3	1.6	5.4	-0.5	-1.4	-0.9	-0.4	0.3	-2.3	0.8	-1.3	-0.7	-0.0	-1.8	-2.2
Forced vital capacity (FVC)	0.7	2.6	4.8	-2.1	-1.2	-1.1	2.1	-1.7	-0.8	-2.2	1.7	-0.9	2.1	-0.7	1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	3.7	-0.4	-0.8	0.1	-1.2	-0.8	-1.5	-0.7	1.9	-0.4	1.0	-0.5	1.5
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	2.0	-0.8	-0.2	-1.1	-1.4	-0.2	0.4	-0.4	0.5	0.2	0.7	-0.3	0.4
Qualifications: None of the above	2.3	4.8	10.2	2.6	3.0	1.9	-0.1	2.3	-0.9	2.2	-2.0	3.2	-2.4	2.7	-0.7
Financial difficulties in last 2 years	2.4	3.3	10.0	-1.1	-2.0	-3.2	0.1	-1.7	-0.8	-1.4	1.0	-2.4	1.9	-2.9	-0.2
Mouth/teeth dental problems	0.7	1.1	3.5	-0.5	-1.1	-1.9	0.9	-1.0	-1.0	-1.1	0.9	-0.9	1.3	-1.0	-0.0
Heart attack	0.6	0.7	4.1	0.2	-0.7	0.1	-0.6	0.8	0.0	0.9	-0.7	0.8	-0.8	2.0	-0.8
Allergy	0.2	0.5	2.4	0.5	0.1	1.6	-0.7	0.3	-0.8	0.2	0.0	1.1	-0.7	0.9	0.1
Pain all over the body in last month	1.1	1.2	2.3	1.1	0.8	0.9	1.5	1.1	0.1	1.3	-1.1	0.8	-1.3	1.3	-1.2
Diabetes (self-reported)	2.7	4.2	13.2	2.7	0.8	-0.5	1.0	2.3	-0.5	2.3	-2.8	2.1	-2.0	0.8	-3.6
Hayfever/allergic rhinitis (self-reported)	0.3	0.5	1.6	-0.1	-0.3	-0.4	0.7	0.5	-1.3	0.8	-0.5	-0.9	-0.3	-0.4	-1.1
Medication: Ramipril	0.5	0.7	4.2	1.1	1.1	0.8	-0.4	0.1	2.0	0.2	0.1	0.2	-0.4	0.2	0.3
Medication: Simvastatin	1.9	2.7	5.4	1.5	1.8	1.7	-0.2	1.7	1.6	1.5	-1.4	2.0	-2.2	2.3	-0.4
Fluid intelligence score	0.5	1.1	5.0	-1.5	-0.2	-0.8	0.4	-0.0	-1.3	0.2	0.1	-1.8	0.3	-2.2	-0.6
Illnesses of siblings	9.1	12.7	22.1	-4.7	-3.3	-2.0	-0.9	-4.6	0.6	-4.5	4.7	-3.2	4.4	-2.0	4.2
Neuroticism score	0.5	1.1	3.2	-0.1	-1.1	-1.5	-0.4	-0.9	0.8	-0.9	0.5	-1.8	0.9	-1.8	-0.3
Weight	0.2	0.8	2.8	1.3	-0.7	-1.0	-0.2	-0.6	0.4	-0.7	1.7	-0.0	0.9	-0.2	1.1
Impedance of arm (right)	0.2	0.9	1.5	-0.6	-1.2	-1.1	-1.0	-0.9	-1.1	-0.8	0.5	-1.2	0.8	-1.2	-0.3
Arm fat percentage (right)	0.2	0.8	3.5	1.9	-0.3	-1.4	-1.2	-0.3	1.3	-0.3	0.9	-0.5	0.4	-0.4	0.1
Trunk fat-free mass	0.3	1.7	6.2	-0.5	-1.3	-0.8	0.4	-1.2	-0.4	-1.3	2.5	-0.3	1.6	-0.1	2.2
Hip circumference	0.1	0.5	4.0	2.0	-0.3	-1.0	0.2	0.2	0.4	0.1	0.5	-0.1	-0.0	0.1	-0.2
Time employed in main current job	1.2	1.4	5.1	0.5	0.6	1.3	-2.0	-0.6	0.4	-0.9	1.4	-1.1	0.7	-0.4	2.3
Alcohol intake versus 10 years previously	0.4	0.5	4.2	1.0	0.2	0.2	2.0	0.1	0.1	-0.4	0.2	-0.7	0.0	0.3	0.6
Father’s age at death	1.0	1.4	5.2	0.4	-1.2	-2.3	-1.5	-0.0	-1.4	0.3	-0.1	0.8	0.3	-0.9	-2.0
Worrier / anxious feelings	2.2	4.1	7.2	-1.2	-2.0	-2.1	-1.2	-2.4	2.6	-2.3	2.1	-2.7	2.1	-1.0	1.7
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	3.6	-1.1	-1.9	-0.7	-1.0	-0.8	-1.8	-0.6	0.6	-0.5	1.0	-0.3	0.6
Falls in the last year	0.7	0.9	2.3	1.5	0.7	0.8	0.6	1.0	0.6	1.4	-1.2	0.0	-1.0	0.5	-1.1
Hair/balding pattern: Pattern 3	1.3	2.0	3.8	-1.9	-0.3	-0.8	-0.3	-1.6	1.2	-1.5	1.7	-1.5	1.9	-1.5	1.4
Number of live births	3.6	5.1	12.7	-0.1	3.0	2.6	-1.3	2.6	-0.4	2.8	-3.1	1.7	-3.6	0.9	-1.5
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	7.6	-1.7	-0.6	-0.1	2.4	-2.0	-0.2	-2.6	2.3	-1.7	2.1	-1.1	2.8
Pulse rate	4.5	7.7	30.4	2.8	1.7	-0.6	3.2	2.7	-0.4	3.2	-3.5	2.5	-2.2	0.3	-5.5
Happiness	0.3	0.4	1.7	-0.0	-0.1	-0.7	-0.3	0.6	-0.8	0.8	-0.8	0.1	-0.2	-0.1	-1.3
Noisy workplace	1.5	1.8	4.5	2.1	1.3	1.5	-0.8	1.2	-0.2	1.6	-1.3	1.3	-1.7	1.4	-0.5
Qualifications: A levels/AS levels or equivalent	0.5	1.2	3.5	-1.2	-1.5	-1.1	0.7	-1.3	-0.1	-0.9	0.7	-0.5	1.3	-1.9	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.5	0.9	0.7	-0.3	0.1	1.3	0.3	1.2	-1.3	1.5	-0.4	1.1	-1.6
Mouth/teeth dental problems: Dentures	0.1	0.2	0.7	0.2	-0.2	0.3	-0.9	-0.5	0.7	-0.3	0.6	0.2	0.5	0.5	0.5
Asthma	0.1	0.2	0.8	0.9	-0.4	-0.4	0.2	0.3	0.0	0.1	-0.8	-0.4	0.3	-0.6	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	4.6	-0.1	-0.3	0.0	-2.1	-0.4	0.8	-0.3	0.7	-0.5	0.3	0.1	0.7
Medication: Cholesterol lowering	0.2	0.3	0.8	0.7	-0.4	0.1	0.2	0.5	0.6	0.6	-0.4	0.9	-0.9	0.4	-0.4
Depression (self-reported)	1.2	1.4	2.9	-1.3	-1.7	-1.6	-1.5	-1.0	-1.1	-0.6	1.4	-0.4	1.7	-0.4	0.2
Medication: Lansoprazole	0.7	0.8	2.6	0.7	0.9	0.5	-1.1	0.8	0.1	0.7	-1.0	1.6	-1.0	0.3	-0.8
Prospective memory result	0.5	0.6	2.5	1.0	-0.8	-0.5	0.6	-0.7	0.3	-0.7	0.8	0.3	0.7	1.6	0.8
Lung cancer (father)	0.7	0.8	3.5	0.4	0.8	0.1	1.9	0.7	-0.1	0.5	-1.4	-0.1	-0.9	-0.0	-1.3
Illnesses of mother	2.3	2.9	5.6	-2.1	-1.9	-2.2	-1.5	-1.8	0.7	-1.6	1.8	-1.5	2.4	-1.1	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.6	9.4	-1.9	-0.6	0.3	3.0	-1.8	-0.7	-2.4	1.9	-1.7	2.0	-1.3	3.1
Pulse wave Arterial Stiffness index	0.2	0.3	1.7	-0.7	0.2	-0.2	0.2	-0.3	-1.3	-0.2	0.1	-0.6	-0.0	-0.8	0.2
Impedance of arm (left)	0.1	0.3	1.0	-0.5	-0.7	-0.6	0.1	-0.4	-1.0	-0.3	-0.1	-0.9	0.3	-0.7	-0.7
Arm fat mass (right)	0.2	0.7	3.1	1.8	-0.3	-1.0	-0.9	-0.2	1.0	-0.2	1.1	-0.2	0.4	-0.2	0.5
Trunk predicted mass	0.3	1.7	6.5	-0.5	-1.4	-0.8	0.4	-1.2	-0.5	-1.3	2.5	-0.3	1.6	-0.1	2.2
Standing height	0.4	3.9	9.7	-1.3	-2.7	-1.2	1.0	-2.0	-2.0	-2.3	3.1	-0.6	2.3	-0.7	2.5
Length of working week for main job	2.0	2.3	4.3	1.7	0.7	2.1	0.7	1.8	-0.9	1.8	-1.9	1.6	-1.9	0.3	-1.3
Exposure to tobacco smoke at home	1.3	1.5	4.0	1.1	0.6	-0.1	0.0	1.8	0.2	2.0	-2.0	0.4	-1.3	0.9	-1.6
Breastfed as a baby	2.5	3.1	7.4	0.5	2.6	2.7	0.6	2.0	-0.9	2.0	-1.2	1.4	-2.2	2.1	0.7
Tense / ‘highly strung’	0.9	1.5	5.8	-1.1	-0.9	-1.8	-0.0	-1.2	-0.5	-1.1	0.4	-2.4	1.3	-1.6	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.2	-0.8	-1.1	-0.6	0.5	-0.3	0.5	-0.2	0.2	0.0	0.8	-0.3	-0.3
Hair/balding pattern: Pattern 4	0.2	0.5	1.2	1.0	-0.7	-0.1	-1.1	0.3	0.9	-0.0	-0.5	1.1	-0.3	1.1	-0.1
Birth weight of first child	2.6	4.7	8.8	-1.6	-1.7	-1.9	-2.1	-2.9	-0.6	-2.0	3.0	-2.4	2.6	-2.6	1.5
Peak expiratory flow (PEF)	0.6	1.4	4.1	-0.1	-0.4	0.5	2.0	-1.1	-0.5	-1.5	1.0	-1.4	1.2	-1.7	1.0
Pulse wave reflection index	2.6	3.2	8.4	-1.8	-0.9	-0.5	-2.3	-1.9	-0.9	-1.8	1.6	-2.9	1.5	-1.5	2.2
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.3	-1.6	-0.8	-1.6	-1.1	-0.9	0.0	-1.1	0.4	-1.1	0.8	-1.8	0.3
Loud music exposure frequency	0.4	0.5	1.7	0.2	0.2	-1.2	0.5	-0.1	-0.6	-0.4	0.2	-1.1	0.4	-1.3	0.4
Qualifications: O levels/GCSEs or equivalent	2.6	4.2	7.2	-2.1	-2.7	-1.6	1.1	-2.4	1.1	-2.3	1.8	-2.6	2.3	-2.6	1.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.6	-0.8	-0.8	0.7	-0.1	0.5	0.0	0.4	-0.8	-0.2	-0.8	-0.6	-0.2
Blood clot in the leg (DVT)	0.2	0.2	1.2	-0.1	0.3	0.3	0.6	0.5	-0.1	0.6	-0.3	0.3	-0.4	1.1	-0.1
Medication: Paracetamol	1.0	1.6	4.3	-1.2	-2.1	-2.1	-0.4	-1.5	0.0	-1.3	1.0	-0.4	1.7	-0.8	0.3
Headache pain in last month	3.6	6.1	17.5	-2.1	-4.2	-3.5	-1.8	-2.6	-1.7	-1.9	2.0	-1.9	3.1	-2.3	0.4
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.8	-1.7	0.5	-0.4	-0.5	-0.8	0.4	-0.7	0.6	-1.3	1.1	-1.1	0.9
Glaucoma (self-reported)	0.7	0.8	2.0	-1.2	0.4	0.5	0.0	0.7	-0.5	0.6	-1.3	0.8	-1.0	-1.0	-1.4
Gout (self-reported)	0.9	1.3	4.8	0.6	0.3	0.6	-0.3	1.5	0.4	1.7	-1.7	0.7	-1.1	-0.3	-2.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.4	-0.9	-1.0	0.2	0.0	-0.8	-0.5	-0.8	1.2	-0.8	0.8	-0.7	0.7
Medication: Amlodipine	0.2	0.3	1.0	0.3	0.7	0.7	0.1	0.0	1.0	-0.3	-0.1	0.5	-0.1	0.9	0.2
Medication: Ventolin 100micrograms inhaler	0.5	0.6	5.6	0.4	-0.7	0.1	2.4	0.3	-0.2	-0.1	-1.0	0.2	-0.3	-0.5	-0.1
Birth weight	1.5	3.3	6.0	-1.2	-1.5	-0.5	-0.7	-2.1	1.3	-2.2	2.4	-2.3	2.1	-1.7	2.5
Chronic bronchitis/emphysema (mother)	0.7	0.9	3.8	0.4	-0.3	1.8	-0.7	-0.8	0.3	-0.6	0.5	0.2	-0.2	1.0	1.9
High blood pressure (siblings)	1.6	2.3	8.1	2.8	1.3	0.2	1.5	1.7	0.3	1.5	-2.0	0.4	-1.8	0.7	-1.7
Forced vital capacity (FVC), Best measure	0.8	3.1	6.2	-2.4	-1.4	-0.5	2.5	-1.6	-1.5	-2.2	1.4	-1.4	2.0	-1.2	2.1
Body fat percentage	0.2	0.6	5.2	2.3	0.3	-0.6	-0.7	0.3	1.1	0.3	0.2	-0.0	-0.2	0.2	-0.2
Leg fat percentage (right)	0.2	0.6	4.3	2.1	0.6	-0.7	-0.9	0.5	0.9	0.6	0.0	0.3	-0.2	0.1	-0.4
Arm fat-free mass (right)	0.1	0.5	2.8	0.2	-0.3	0.2	0.3	-0.2	-0.0	-0.4	1.3	0.4	0.4	0.4	1.7
Exposure to tobacco smoke outside home	0.2	0.3	1.7	0.1	-0.5	-1.3	0.7	-0.2	-0.6	0.0	0.1	0.0	0.2	-0.9	-0.5
Comparative body size at age 10	0.9	2.6	4.8	0.7	1.3	2.0	-1.4	2.2	-0.3	2.0	-1.8	1.6	-2.2	1.5	-1.3
Number of full brothers	1.5	1.9	3.8	0.4	1.1	0.7	-0.1	1.6	-1.8	1.4	-1.9	1.9	-1.4	0.5	-1.8
Worry too long after embarrassment	0.8	1.4	3.2	1.8	-1.1	-1.4	0.3	-1.1	1.6	-0.7	1.4	-1.2	1.3	-0.6	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.3	4.6	1.3	0.3	1.4	-0.7	1.7	-0.1	2.0	-2.1	1.5	-1.8	1.4	-2.0
Wheeze or whistling in the chest in last year	0.2	0.4	1.6	1.3	-0.0	0.2	-0.2	0.8	0.0	0.9	-1.0	0.3	-0.7	0.3	-0.6
Number of children fathered	1.6	1.8	4.2	1.2	2.1	1.4	1.1	1.2	1.0	1.3	-1.1	1.4	-1.3	1.8	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	4.5	0.2	-0.9	-1.8	2.1	0.0	-0.6	-0.1	-0.5	-1.0	0.3	-1.4	-1.5
Age at first live birth	0.7	1.2	2.4	-1.3	0.1	0.7	0.8	-1.1	1.6	-1.1	1.3	-1.3	0.7	-0.7	1.6
Pulse wave peak to peak time	0.2	0.3	1.5	0.6	-0.4	0.1	0.0	0.2	1.2	0.1	0.1	0.7	0.2	0.8	-0.1
Health satisfaction	1.1	1.4	4.3	1.6	0.6	-0.6	-0.7	1.4	-1.1	1.7	-1.3	-0.5	-0.7	0.4	-2.1
Shortness of breath walking on level ground	0.3	0.4	1.8	-0.0	0.6	0.2	0.5	-0.1	1.0	-0.6	0.5	-0.9	-0.2	-0.1	1.3
Qualifications: College or University degree	0.6	1.8	7.4	-2.7	-1.6	-1.0	-0.3	-1.1	-0.1	-0.9	0.8	-0.5	1.1	-2.3	-0.8
Eye problems/disorders: None of the above	1.3	1.5	3.6	-1.6	-1.2	-0.0	-1.5	-1.3	-0.5	-1.2	1.6	-0.9	1.2	0.1	1.9
Mouth/teeth dental problems: Loose teeth	0.3	0.4	2.8	1.7	-0.4	0.0	-1.1	0.1	0.6	-0.1	-0.0	-0.0	-0.3	-0.4	0.1
Emphysema/chronic bronchitis	0.5	0.6	1.8	1.3	1.4	0.2	0.7	0.4	1.1	0.5	-0.6	0.5	-0.8	-0.3	-0.6
Medication for pain relief, constipation, heartburn	0.7	1.2	4.0	-1.0	1.6	2.0	1.6	0.2	0.5	-0.1	0.2	-0.5	-0.5	-0.6	1.6
Neck or shoulder pain in last month	1.1	1.6	4.3	1.4	1.4	0.0	-0.3	1.7	-0.8	2.1	-1.7	0.8	-1.1	0.4	-1.4
Medication: Blood pressure	1.4	2.4	6.9	2.6	0.1	1.2	-0.1	1.4	-0.7	1.1	-1.2	2.5	-1.7	2.1	-1.4
Angina (self-reported)	0.8	1.1	3.1	0.7	0.1	-0.5	-1.4	1.4	-0.4	1.8	-0.8	0.8	-0.9	1.1	-1.4
Migraine (self-reported)	2.1	2.6	6.6	-2.6	-2.1	-2.4	0.4	-1.4	-2.0	-1.5	1.3	-0.5	1.5	-1.2	0.3
Medication: Ibuprofen	0.2	0.3	1.3	0.2	0.2	0.5	-1.1	-0.1	0.9	-0.1	0.4	-0.3	-0.2	0.4	0.8
Medication: Allopurinol	0.4	0.5	2.4	-0.2	-0.5	0.4	-1.6	0.6	0.4	0.8	-0.8	-0.1	-0.5	-0.8	-0.9
Medication: Omeprazole	0.4	0.4	1.7	-0.3	-0.8	-0.3	-1.2	-0.3	1.3	-0.4	0.3	0.3	-0.0	0.3	0.8
Medication: Seretide 50 evohaler	1.2	1.3	4.3	1.8	0.4	-0.6	1.1	1.1	-0.6	1.2	-1.4	0.2	-1.2	-0.3	-2.1
Mean time to correctly identify matches	0.8	1.6	4.5	2.1	-0.9	-0.6	-0.9	1.0	-0.4	1.2	-1.4	1.5	-1.3	0.3	-2.0
Heart disease (mother)	0.9	1.1	3.3	1.6	-0.3	-0.0	1.0	1.0	-1.4	0.9	-1.0	0.4	-1.1	-0.3	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.9	0.1	0.8	0.8	1.1	1.5	-0.4	1.4	-1.7	1.4	-1.5	1.2	-0.9
Whole body fat mass	0.1	0.6	4.0	2.0	0.0	-0.9	-0.5	-0.0	0.8	-0.1	0.8	0.1	0.2	0.1	0.4
Leg fat mass (right)	0.1	0.6	3.6	1.9	0.1	-0.8	-0.8	0.0	0.8	-0.0	0.8	0.2	0.3	-0.0	0.5
Arm predicted mass (right)	0.1	0.5	2.3	0.3	-0.4	0.1	0.3	-0.2	-0.3	-0.4	1.4	0.5	0.5	0.5	1.5
Pulse rate, automated reading	2.5	7.9	32.7	1.8	1.5	0.1	2.2	2.7	-2.3	3.5	-4.0	2.0	-2.5	-0.9	-5.7
Alcohol intake frequency.	0.3	0.6	1.5	0.5	-0.6	-1.2	-1.0	-0.5	-0.5	-0.4	1.2	0.5	1.0	0.8	0.8
Comparative height size at age 10	0.1	0.4	1.3	0.9	-0.0	0.0	0.2	0.4	-1.0	0.6	0.7	0.8	-0.2	1.2	0.7
Number of full sisters	1.2	1.5	3.4	0.4	0.1	0.9	1.0	1.5	-0.8	1.4	-1.8	1.0	-1.6	1.0	-1.8
Suffer from ‘nerves’	2.2	3.4	7.6	-2.4	-1.9	-2.2	0.2	-2.0	-0.4	-1.6	1.2	-2.8	1.9	-2.7	0.1
Overall health rating	1.4	3.0	9.1	3.0	1.6	0.5	-0.4	2.0	0.2	2.3	-1.6	1.2	-1.6	2.2	-1.8
Chest pain or discomfort	0.6	0.9	2.4	1.0	-0.7	-1.4	0.9	0.2	-1.5	0.1	-0.7	-0.7	0.3	-0.9	-1.5
Had major operations	0.3	0.3	1.0	-0.3	-0.7	-0.8	0.2	-0.3	1.0	-0.3	0.0	-0.5	0.5	-0.5	-0.6
Age at last live birth	0.9	1.4	4.8	-2.2	0.1	0.2	0.7	-1.2	1.2	-1.4	0.9	-1.4	0.7	-1.2	1.2
Family relationship satisfaction	1.7	2.1	5.0	-1.4	-1.5	-2.2	-1.5	-1.4	-0.8	-1.2	1.1	-1.6	1.5	-1.7	0.3
Leg pain on walking	0.6	0.8	4.0	2.0	1.1	0.1	-0.3	0.8	0.8	1.2	-0.5	0.1	-0.5	0.8	-0.9
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	5.3	2.3	1.1	0.8	0.2	0.0	2.3	0.0	0.1	0.5	0.1	1.9	1.2
Commuting to job workplace: Car/motor vehicle	1.1	1.2	2.6	1.2	-0.4	-1.3	1.6	-1.2	1.4	-0.7	0.8	-0.7	1.4	-1.4	-0.4
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	5.7	0.1	1.6	2.4	-0.7	0.1	0.4	0.2	0.3	-0.0	-0.8	0.3	1.8
Medication: Aspirin	2.7	3.6	10.8	3.0	0.4	-0.1	0.4	2.0	-1.0	2.4	-2.2	1.7	-1.7	1.3	-3.3
Supplements: Vitamin C	0.5	0.6	2.6	-1.6	-0.7	-1.6	0.5	-0.6	0.3	-0.6	0.3	-0.8	0.7	-0.2	-0.1
Knee pain experienced in last month	0.4	0.6	1.7	1.0	-0.6	-1.0	-1.3	-0.1	-1.1	0.2	0.3	0.4	0.8	0.9	-0.1
Hypertension (Self-reported)	2.5	6.9	13.6	3.7	2.7	2.0	1.8	3.2	0.9	2.5	-2.7	2.9	-3.0	2.8	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	5.7	-0.5	-0.9	0.3	-2.4	-0.6	0.8	-0.6	0.6	0.1	0.3	1.2	0.8
Illnesses of father: Heart disease	0.4	0.5	2.7	-0.0	-0.6	-1.6	-0.5	0.1	-0.1	0.2	-0.0	-0.8	0.5	-1.3	-0.5
Illnesses of siblings: Diabetes	5.7	7.1	13.5	2.7	2.0	1.7	1.9	3.4	0.3	3.1	-3.7	2.6	-3.5	2.0	-2.9
Smoking status: Previous	1.5	2.2	5.8	1.6	1.5	0.1	1.5	1.7	-0.6	1.6	-2.1	1.0	-1.2	-0.7	-2.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	3.9	-0.2	-0.3	-0.6	2.0	-0.1	-1.5	-0.1	0.4	-0.7	0.9	-0.7	0.2
Whole body fat-free mass	0.3	1.6	6.5	-0.1	-1.1	-0.6	0.4	-1.2	0.2	-1.4	2.5	-0.4	1.5	-0.1	2.4
Leg fat-free mass (right)	0.3	1.8	6.6	0.3	-1.0	-0.7	0.3	-1.4	0.5	-1.6	2.6	-0.7	1.6	-0.4	2.3
Arm fat percentage (left)	0.2	0.7	4.6	2.1	0.3	-0.9	-0.6	0.2	1.2	0.2	0.3	-0.2	-0.1	0.0	-0.3
Average weekly red wine intake	0.7	1.1	3.8	-1.9	-0.4	-0.7	-0.7	0.9	-1.1	0.9	-1.2	0.6	-0.7	-0.4	-1.6
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.3	-0.5	-0.6	-0.7	-0.4	0.6	-0.4	0.8	-0.8	-0.7	-0.4	-0.2	-1.1
Mood swings	0.8	1.4	6.3	-0.5	-0.7	-1.5	-0.3	-0.9	-0.7	-1.0	0.9	-2.5	1.2	-1.7	0.7
Loneliness, isolation	0.6	0.8	4.5	1.1	-1.1	-0.1	2.1	0.4	-1.2	0.3	-0.5	-0.4	-0.3	-0.3	-0.8
Long-standing illness, disability or infirmity	1.3	2.0	5.3	2.0	-1.0	-0.0	0.6	1.1	-2.3	1.2	-1.5	1.5	-1.1	0.8	-2.2
Ever had bowel cancer screening	1.5	1.8	7.6	2.8	0.3	0.2	-1.3	1.0	-0.8	1.0	-1.4	1.5	-1.3	0.9	-1.7
Diabetes diagnosed by doctor	2.6	4.2	17.8	2.7	0.1	-1.3	1.2	2.0	-1.3	2.3	-2.7	1.6	-1.5	-0.1	-4.2
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	4.3	1.0	-1.0	-0.6	2.1	-0.5	-0.9	-0.0	1.0	-1.0	0.7	-0.9	-0.6
Friendships satisfaction	0.7	0.9	4.8	0.6	-0.1	-1.0	0.2	0.8	-0.3	1.0	-0.7	0.9	-0.5	1.0	-2.2
Qualifications: nursing, teaching	0.5	0.8	5.3	-0.9	-0.1	0.2	-0.4	-0.7	2.3	-0.9	0.7	0.9	0.1	-0.6	0.7
Commuting to job workplace: Walk	0.6	0.6	5.2	0.3	-0.2	0.6	-2.3	0.3	-0.3	-0.1	0.5	0.5	-0.3	0.8	0.5
Eye problems/disorders: Cataract	0.6	0.7	2.5	1.5	1.3	-0.2	0.9	0.5	1.6	0.3	-0.4	0.5	-0.4	0.2	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.1	0.2	0.6	-0.5	-0.3	0.9	0.6	1.0	-1.1	0.3	-0.8	0.8	-0.4
Medication for cholesterol	0.6	1.0	2.0	-1.2	-1.1	0.2	-0.3	-1.1	-0.1	-1.1	1.2	-1.3	0.7	-0.8	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.8	1.7	-0.7	-1.9	1.9	0.5	0.6	0.3	-0.6	-0.1	0.3	0.2	-2.0
Back pain experienced in last month	0.3	0.4	1.7	-1.0	-0.3	-0.1	-1.3	-0.4	-1.0	-0.0	0.4	0.5	0.4	-0.1	0.5
Mineral and other dietary supplements	0.3	0.3	1.1	-1.0	-0.1	-0.6	-0.5	-0.6	-0.2	-0.6	0.7	0.5	0.3	0.3	0.9
Breast cancer (self-reported)	1.3	1.5	4.2	-1.6	-1.8	-0.5	-1.8	-0.9	-0.6	-0.7	0.3	-1.6	0.8	-2.1	0.2
Asthma (self-reported)	0.1	0.3	1.4	1.2	-0.1	0.0	0.4	0.6	0.0	0.3	-1.1	0.0	-0.1	-0.3	-0.5
Osteoporosis (self-reported)	0.5	0.6	1.3	0.5	0.7	0.7	0.5	0.5	-0.1	0.6	-1.0	1.1	-1.0	1.0	-0.9
Osteoarthritis (self-reported)	1.6	2.1	3.5	1.4	0.3	1.2	-0.9	1.5	-1.3	1.8	-1.9	1.4	-1.7	1.6	-1.4
Medication: Aspirin	2.5	3.3	8.7	2.9	0.3	0.0	0.6	1.9	-0.5	2.2	-2.0	1.9	-1.7	1.8	-2.8
Medication: Gliclazide	1.5	1.8	4.8	1.0	-1.2	-0.8	0.6	1.0	-2.0	1.4	-1.8	-1.0	-0.8	-0.9	-2.2
Illnesses of father: None of the above (group 1)	0.7	0.9	3.5	-1.0	-0.4	0.6	0.1	-1.0	-0.7	-1.4	1.3	-0.3	0.7	-0.2	1.9
Smoking status: Current	0.2	0.3	2.2	0.0	-0.8	0.1	0.7	-0.3	-1.5	0.2	0.4	-0.0	0.2	-0.1	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	4.5	-1.6	-1.2	-0.9	1.4	-1.9	0.0	-2.1	1.4	-2.1	1.7	-2.1	1.9
Whole body water mass	0.2	1.4	5.7	0.1	-1.0	-0.5	0.4	-1.1	0.2	-1.2	2.4	-0.3	1.4	0.1	2.3
Leg predicted mass (right)	0.3	1.7	6.2	0.4	-0.9	-0.6	0.3	-1.3	0.6	-1.6	2.5	-0.6	1.5	-0.2	2.3
Arm fat mass (left)	0.1	0.6	3.1	1.8	-0.2	-1.1	-0.7	-0.1	1.0	-0.1	0.9	0.0	0.3	-0.0	0.2
Number of self-reported non-cancer illnesses	1.3	2.3	6.8	1.8	0.5	-0.2	1.2	1.6	-0.7	1.8	-1.6	2.1	-1.3	1.1	-2.6
Average weekly champagne plus white wine intake	0.4	0.6	2.1	-0.4	0.0	-0.2	0.5	1.0	-0.8	1.2	-0.4	0.8	-0.4	1.4	-0.5
Miserableness	0.1	0.3	0.8	-0.5	-0.8	-0.8	-0.9	0.3	-0.0	0.2	-0.0	-0.3	0.2	0.1	-0.6
Guilty feelings	0.5	0.7	2.6	0.8	-0.3	-1.4	-0.6	0.4	1.3	0.6	-0.8	-0.1	0.0	-0.6	-1.6
Wears glasses or contact lenses	0.2	0.2	1.3	-0.0	-1.1	0.3	-0.2	-0.2	0.2	-0.2	-0.2	0.9	-0.1	0.2	-0.7
Ever taken oral contraceptive pill	1.4	1.6	4.4	0.4	1.1	0.3	1.2	1.2	-1.5	0.9	-1.3	1.9	-0.7	1.0	-2.1
Hearing aid user	0.4	0.4	1.5	0.3	-0.8	-0.1	0.1	-0.5	-1.0	-0.7	0.5	-1.2	0.4	-0.6	0.4
Mother’s age at death	1.0	1.2	2.6	0.3	-1.4	-0.8	-0.1	-1.3	-1.6	-0.8	1.3	-1.1	1.2	-1.6	-0.3
Financial situation satisfaction	1.0	1.3	5.1	-2.3	-0.5	-1.5	-0.9	-0.4	-1.2	-0.6	-0.4	-1.0	0.2	-1.7	-0.6
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.3	-0.9	-1.0	-0.0	-1.1	-0.8	-0.8	-0.6	0.8	-0.3	0.6	-1.1	0.6
Commuting to job workplace: Public transport	0.2	0.2	0.8	-0.4	-0.9	-0.7	0.5	0.0	-0.7	-0.3	0.4	0.2	0.4	0.3	-0.3
Eye problems/disorders: Glaucoma	0.6	0.7	3.1	-1.8	0.3	0.4	0.2	0.4	0.2	0.1	-1.2	0.1	-0.8	-1.5	-0.9
Medication: Blood pressure	2.1	4.0	7.5	2.6	2.7	1.1	1.1	2.4	-0.0	2.4	-1.9	2.6	-1.9	1.9	-1.7
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.8	0.5	1.5	0.4	-1.7	1.1	-0.1	0.9	-0.7	0.5	-1.0	1.4	-0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.7	0.1	-0.1	-0.4	0.3	-0.2	0.5	-0.2	-0.0	-1.3	0.3	-0.8	0.2
High cholesterol (Self-reported)	0.9	1.6	2.9	1.5	1.4	0.8	-0.3	1.4	1.6	1.3	-1.0	1.3	-1.5	1.7	-0.5
Medication: Bendroflumethiazide	1.3	2.0	11.8	3.4	0.9	0.8	1.0	0.8	-0.6	0.6	-0.5	2.1	-0.4	1.7	-0.8
Medication: Paracetamol	0.5	0.7	1.9	-0.9	-1.4	-1.3	0.1	-1.0	0.9	-0.9	0.6	-0.3	1.0	-0.6	0.1
Medication: Lisinopril	1.1	1.5	11.2	1.6	-0.3	0.3	3.3	0.7	-0.2	0.5	-0.3	1.1	-0.4	0.9	-0.9
Medication: Atorvastatin	0.3	0.4	1.3	0.1	-0.2	-1.0	0.9	0.7	0.3	0.8	-0.6	0.2	-0.1	0.3	-1.2
Illnesses of father: High blood pressure	0.5	0.7	2.3	1.5	-0.7	-0.9	0.5	-0.1	1.1	0.3	-0.6	-0.4	0.1	-0.0	-1.5
Alcohol drinker status: Never	1.3	1.5	7.3	-1.5	-1.4	-1.3	-2.7	-0.8	-0.7	-0.8	1.0	-0.9	0.7	-0.5	0.9
Ever smoked	1.5	2.7	7.7	0.3	0.5	-0.1	2.2	1.6	-1.8	1.8	-2.5	0.3	-1.4	-1.6	-2.8
Basal metabolic rate	0.3	1.5	6.2	0.3	-0.9	-0.7	0.2	-1.1	0.2	-1.3	2.5	-0.3	1.4	-0.1	2.3
Leg fat percentage (left)	0.2	0.7	5.2	2.3	0.7	-0.6	-0.7	0.6	0.7	0.8	-0.2	0.4	-0.4	0.1	-0.7
Arm fat-free mass (left)	0.2	0.9	3.6	0.1	-0.7	-0.2	-0.3	-0.8	0.0	-0.9	1.9	0.1	1.0	-0.0	1.9
Number of operations (self-reported)	1.1	1.6	8.2	0.8	-0.7	-1.6	0.6	1.0	-1.1	1.5	-1.4	0.5	-0.3	-0.1	-2.9
Average weekly beer plus cider intake	0.2	0.3	1.4	-0.2	0.3	0.3	0.0	-0.8	0.6	-0.8	0.4	0.2	0.5	0.5	1.2
Irritability	0.3	0.4	1.9	-0.2	-0.6	-0.3	-1.1	-0.2	-0.7	-0.1	0.0	-1.4	0.4	-1.0	0.1
Risk taking	0.5	0.7	7.1	-0.2	-0.4	0.0	2.7	-0.1	-0.2	0.2	-0.2	-0.1	0.3	0.8	0.3
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.4	-0.2	-1.1	-1.2	0.5	-0.4	-0.5	-0.5	0.5	0.6	0.4	-0.4	-0.3
Fractured/broken bones in last 5 years	1.2	1.5	2.9	-0.2	1.3	0.9	-1.2	1.4	1.6	1.5	-1.7	0.3	-1.6	1.2	-0.7
Age started oral contraceptive pill	0.9	1.1	2.2	-0.8	-0.9	0.1	-1.1	-1.3	0.6	-1.4	0.9	-0.8	0.9	-1.5	1.3
Diastolic blood pressure, automated reading	1.3	3.9	12.4	3.5	1.9	0.3	1.9	2.5	-0.4	2.1	-2.1	1.5	-1.9	0.8	-2.6
Ever depressed for a whole week	0.9	1.1	2.8	-1.2	-0.5	-1.6	-1.7	-0.7	-0.6	-0.9	1.2	-0.7	1.3	-0.6	0.6
Unable to work because of sickness or disability	1.4	1.8	5.3	2.3	1.1	0.7	0.6	1.1	1.6	1.2	-0.9	1.5	-0.8	1.8	-1.3
Commuting to job workplace: Cycle	0.5	0.6	2.3	-0.3	-0.7	-0.0	-1.5	-0.7	-0.5	-0.6	1.1	-0.2	0.6	-0.3	1.3
Myopia	0.4	0.6	2.6	-0.7	0.3	0.8	-0.4	-0.8	0.6	-0.4	0.7	-0.6	0.5	0.7	1.6
Vascular/heart problems diagnosed by doctor	1.9	5.3	9.0	-3.0	-1.7	-1.7	-0.8	-2.9	0.1	-2.5	2.5	-2.8	2.8	-2.4	2.3
Cholesterol lowering medication	2.1	3.2	5.5	1.8	1.7	1.0	0.6	2.1	0.7	2.1	-2.4	1.7	-2.3	1.9	-1.9
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	1.2	-0.3	-0.7	-0.7	-0.7	-0.2	1.1	-0.4	0.2	0.4	0.1	0.5	0.4
Pain experienced in last month	0.6	0.9	3.2	-0.9	-0.1	0.7	0.7	-0.9	1.8	-1.4	0.5	-1.1	0.3	-0.6	1.1
Supplements: Calcium	0.6	0.7	3.0	-0.2	-0.4	0.3	-0.6	0.5	0.3	0.6	-1.7	-0.2	-1.0	0.2	-1.6
Basal cell carcinoma (self-reported)	0.3	0.3	0.9	0.0	0.8	0.4	-0.8	-0.0	0.9	0.2	0.4	-0.9	-0.0	0.3	0.6
Heart attack/myocardial infarction (self-reported)	0.7	0.9	5.5	0.4	-0.5	0.3	-0.5	0.9	0.2	1.1	-0.8	0.9	-1.0	2.3	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.8	-0.3	0.2	0.1	0.3	0.2	0.1	0.4	0.1	-0.0	-0.0	0.9	0.1
Heart disease (siblings)	2.3	2.8	7.5	2.7	1.7	1.2	-1.3	1.8	0.5	1.8	-1.5	2.4	-1.8	0.6	-1.1
Alcohol drinker status: Previous	1.3	1.5	2.6	0.6	1.6	1.3	0.7	1.1	0.9	1.2	-1.5	1.6	-1.4	1.5	-0.7
Pack years of smoking	1.1	1.6	5.9	1.8	0.9	1.0	0.2	0.8	0.8	0.8	-0.6	1.8	-1.4	2.4	0.1
Impedance of whole body	0.1	0.4	2.3	-0.7	-0.3	0.2	-0.3	0.1	-1.5	0.1	-0.7	-0.5	-0.3	-0.4	-0.7
Leg fat mass (left)	0.1	0.5	3.8	2.0	0.1	-0.8	-0.7	0.1	0.7	0.0	0.7	0.2	0.2	-0.1	0.3
Arm predicted mass (left)	0.2	0.8	3.7	0.1	-0.6	-0.1	-0.4	-0.6	0.2	-0.8	1.8	0.1	0.9	0.2	1.9