Hub : Traits :

Medication: Simvastatin

80 significantly associated models · 35 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 61510619 63844736 3 1 1.3e-11 2.4e-12 1.0e+00 100 DOCK7
2 1 108854166 110742615 6 1 9.1e-36 7.0e-36 1.0e+00 100 PSRC1
3 2 20529948 21958745 1 1 8.6e-25 2.0e-25 1.0e+00 100 APOB
4 2 43342098 44759941 1 1 2.6e-08 9.5e-18 4.9e-14 23 ABCG5
5 2 202540420 203931012 1 1 3.4e-07 6.8e-07 4.6e-01 98 RP11-686O6.2
6 5 73969058 75504243 1 1 1.5e-07 1.3e-10 1.1e-04 64 COL4A3BP
7 8 19064892 20521138 1 1 3.5e-07 6.2e-09 3.0e-03 74 LPL
8 11 8725268 10159883 1 1 6.1e-08 2.0e-04 9.7e-03 52 IPO7
9 11 115953897 117745003 2 2 7.3e-15 7.8e-16 3.1e-01 98 PAFAH1B2 ZNF259
10 15 90730363 92135418 1 1 7.3e-08 7.2e-08 1.0e+00 100 FES
11 16 71403083 72845749 2 2 7.5e-08 8.1e-08 1.0e+00 100 DHX38 HPR
12 17 45479446 46874272 1 1 2.3e-09 6.2e-07 9.6e-03 73 CBX1
13 19 10283932 12191233 5 3 3.3e-13 7.0e-38 5.3e-12 71 C19orf80 EPOR LDLR
14 19 44614208 46098885 3 3 5.8e-11 5.0e-70 3.7e-54 23 BCAM PVRL2 TOMM40
15 19 48464978 49906278 2 2 5.7e-08 1.1e-08 1.4e-01 93 FUT2 NTN5
16 20 61989111 62912463 4 1 8.2e-09 2.4e-08 6.7e-01 99 OPRL1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (in mother) 5.20 2 2 6.1 0.00 1.0e+00 BCAM TOMM40
Alzheimer’s Disease (in father) 1.47 1 0 0.0 0.00 1.0e+00 TOMM40
Alzheimer’s Disease (including proxy) 8.86 2 2 6.1 0.00 1.0e+00 BCAM TOMM40
Crohns Disease (2017) 2.29 3 1 3.0 0.00 1.0e+00 DOCK7 FUT2 NTN5
Irritable Bowel Disease (IBD) 1.84 2 0 0.0 0.00 1.0e+00 FUT2 OPRL1
Ulcerative Colitis (UC) 1.65 1 1 3.0 0.00 1.0e+00 OPRL1
Major Depression (MDD) 1.55 1 0 0.0 0.00 1.0e+00 FES
Breast Cancer 0.98 2 0 0.0 0.00 1.0e+00 FES OPRL1
Ovarian Cancer 1.64 1 0 0.0 0.00 1.0e+00 OPRL1
Body Mass Index (BMI) (2010) 1.93 1 0 0.0 0.00 1.0e+00 OPRL1
Coronary Artery Disease (CAD) 6.20 4 2 6.1 -0.81 1.9e-01 EPOR LPL PSRC1 ZNF259
Crohns Disease (2012) 2.59 3 1 3.0 0.00 1.0e+00 DOCK7 FUT2 NTN5
HDL Cholesterol 15.20 5 3 9.1 0.45 4.4e-01 APOB LPL PSRC1 TOMM40 ZNF259
LDL Cholesterol 76.56 18 14 42.4 -0.94 7.4e-09 ABCG5 APOB BCAM C19orf80 CBX1 COL4A3BP DHX38 DOCK7 EPOR HPR LDLR NTN5 OPRL1 PAFAH1B2 PSRC1 PVRL2 TOMM40 ZNF259
Primary Biliary Cirrhosis 1.38 1 0 0.0 0.00 1.0e+00 EPOR
Rheumatoid Arthritis 1.43 1 0 0.0 0.00 1.0e+00 OPRL1
Schizophrenia 1.05 1 1 3.0 0.00 1.0e+00 FES
Triglycerides 43.72 6 5 15.2 -0.81 5.2e-02 APOB DOCK7 HPR LPL PAFAH1B2 ZNF259
Ulcerative Colitis 1.43 2 0 0.0 0.00 1.0e+00 BCAM PAFAH1B2
Blood Eosinophil Count 1.64 9 4 12.1 0.04 9.3e-01 BCAM DOCK7 EPOR LPL OPRL1 PAFAH1B2 PVRL2 TOMM40 ZNF259
Blood Platelet Count 1.93 9 8 24.2 0.50 1.7e-01 COL4A3BP DOCK7 FUT2 HPR LPL NTN5 PAFAH1B2 TOMM40 ZNF259
Blood Red Count 0.85 3 2 6.1 0.00 1.0e+00 CBX1 FES HPR
Blood White Count 0.96 5 1 3.0 0.11 8.5e-01 CBX1 DOCK7 EPOR FES PAFAH1B2
Heel T-Score 1.02 4 1 3.0 0.95 4.9e-02 APOB DOCK7 PSRC1 RP11-686O6.2
BMI 1.86 5 3 9.1 0.38 5.3e-01 ABCG5 COL4A3BP DHX38 HPR OPRL1
Height 0.88 10 5 15.2 0.88 7.4e-04 ABCG5 CBX1 EPOR FES LPL OPRL1 PSRC1 RP11-686O6.2 TOMM40 ZNF259
Waist Hip Ratio (WHR) 1.28 3 1 3.0 0.00 1.0e+00 LPL NTN5 OPRL1
Systolic Blood Pressure 4.12 7 3 9.1 -0.82 2.3e-02 ABCG5 EPOR FES NTN5 OPRL1 PAFAH1B2 TOMM40
Smoking Status 1.33 2 0 0.0 0.00 1.0e+00 DHX38 FES
Allergy or Eczema 1.11 2 0 0.0 0.00 1.0e+00 FES PVRL2
Cardiovascular Disease 13.58 20 18 54.5 -0.96 1.4e-11 ABCG5 APOB BCAM CBX1 COL4A3BP DHX38 DOCK7 EPOR FES FUT2 HPR LPL NTN5 OPRL1 PAFAH1B2 PSRC1 PVRL2 RP11-686O6.2 TOMM40 ZNF259
Respiratory disease 1.19 1 0 0.0 0.00 1.0e+00 FES
Type 2 Diabetes (T2D) 1.87 1 0 0.0 0.00 1.0e+00 LPL
Lung FEV1/FVC ratio 0.97 3 1 3.0 0.00 1.0e+00 HPR NTN5 PSRC1
Lung FVC 0.94 2 1 3.0 0.00 1.0e+00 OPRL1 RP11-686O6.2
Chronotype (morning person) 0.98 1 0 0.0 0.00 1.0e+00 FUT2
Hair Pigment 0.25 6 1 3.0 0.19 7.2e-01 CBX1 DHX38 EPOR FES FUT2 OPRL1
Tanning 0.18 1 0 0.0 0.00 1.0e+00 EPOR
Hand grip strength (left) 1.42 3 0 0.0 0.00 1.0e+00 ABCG5 FES RP11-686O6.2
Number of treatments/medications taken 4.75 6 1 3.0 0.97 9.7e-04 ABCG5 DHX38 FES LDLR NTN5 PSRC1
Sensitivity / hurt feelings 0.96 1 0 0.0 0.00 1.0e+00 FES
Hearing difficulty/problems: Yes 1.78 1 0 0.0 0.00 1.0e+00 CBX1
Systolic blood pressure, automated reading 3.13 2 2 6.1 0.00 1.0e+00 FES OPRL1
Angina 7.37 6 2 6.1 0.97 9.3e-04 ABCG5 C19orf80 FES LPL OPRL1 PSRC1
Medication: Metformin 1.91 1 0 0.0 0.00 1.0e+00 ABCG5
Impedance of leg (right) 1.04 4 1 3.0 0.44 5.6e-01 CBX1 COL4A3BP FES OPRL1
Leg fat-free mass (left) 1.06 3 1 3.0 0.00 1.0e+00 COL4A3BP EPOR FES
Trunk fat percentage 1.21 4 0 0.0 -0.38 6.2e-01 BCAM COL4A3BP DHX38 HPR
Hand grip strength (right) 1.38 2 1 3.0 0.00 1.0e+00 ABCG5 RP11-686O6.2
Age when periods started (menarche) 1.37 3 0 0.0 0.00 1.0e+00 FUT2 NTN5 RP11-686O6.2
Heel bone mineral density (BMD) T-score, automated (left) 0.96 1 0 0.0 0.00 1.0e+00 RP11-686O6.2
High blood pressure 4.32 6 2 6.1 0.96 2.2e-03 ABCG5 CBX1 DHX38 FES NTN5 OPRL1
Hayfever, allergic rhinitis or eczema 1.10 1 0 0.0 0.00 1.0e+00 PVRL2
Medication: Atenolol 3.63 1 1 3.0 0.00 1.0e+00 FES
Sitting height 0.59 2 0 0.0 0.00 1.0e+00 HPR RP11-686O6.2
High blood pressure (mother) 3.25 1 1 3.0 0.00 1.0e+00 FES
Body mass index (BMI) 1.57 3 2 6.1 0.00 1.0e+00 COL4A3BP DHX38 HPR
Impedance of leg (left) 1.06 4 0 0.0 0.47 5.3e-01 CBX1 COL4A3BP FES OPRL1
Leg predicted mass (left) 1.06 3 1 3.0 0.00 1.0e+00 COL4A3BP EPOR PSRC1
Trunk fat mass 1.24 4 1 3.0 -0.36 6.4e-01 BCAM COL4A3BP DHX38 HPR
Waist circumference 1.38 3 1 3.0 0.00 1.0e+00 COL4A3BP DHX38 HPR
Had other major operations 0.87 1 0 0.0 0.00 1.0e+00 OPRL1
Forced vital capacity (FVC) 1.23 4 1 3.0 -0.98 1.8e-02 ABCG5 DHX38 EPOR RP11-686O6.2
Heel bone mineral density (BMD) T-score, automated (right) 0.99 1 0 0.0 0.00 1.0e+00 RP11-686O6.2
Qualifications: None of the above 0.59 1 0 0.0 0.00 1.0e+00 DOCK7
Mouth/teeth dental problems 1.66 2 0 0.0 0.00 1.0e+00 DOCK7 NTN5
Heart attack 4.68 4 1 3.0 0.98 2.1e-02 C19orf80 FES NTN5 PSRC1
Allergy 1.13 2 0 0.0 0.00 1.0e+00 FES PVRL2
Medication: Ramipril 3.64 1 0 0.0 0.00 1.0e+00 FES
Illnesses of siblings 3.31 2 0 0.0 0.00 1.0e+00 FES HPR
Weight 1.30 4 1 3.0 -0.48 5.2e-01 COL4A3BP DHX38 EPOR HPR
Impedance of arm (right) 0.91 3 0 0.0 0.00 1.0e+00 CBX1 COL4A3BP OPRL1
Arm fat percentage (right) 1.65 5 2 6.1 -0.07 9.2e-01 BCAM COL4A3BP DHX38 HPR RP11-686O6.2
Trunk fat-free mass 1.10 3 3 9.1 0.00 1.0e+00 COL4A3BP EPOR PSRC1
Hip circumference 1.38 4 1 3.0 -0.51 4.9e-01 COL4A3BP DHX38 HPR OPRL1
Alcohol intake versus 10 years previously 1.88 1 0 0.0 0.00 1.0e+00 FUT2
Father's age at death 2.70 2 0 0.0 0.00 1.0e+00 FES PSRC1
Falls in the last year 1.20 1 0 0.0 0.00 1.0e+00 IPO7
Forced expiratory volume in 1-second (FEV1) 1.15 3 0 0.0 0.00 1.0e+00 DHX38 EPOR RP11-686O6.2
Serious illness, injury or assault of a close relative in last 2 years 1.50 1 0 0.0 0.00 1.0e+00 NTN5
Mouth/teeth dental problems: Dentures 1.53 1 0 0.0 0.00 1.0e+00 NTN5
Medication: Cholesterol lowering 34.13 23 19 57.6 0.99 9.6e-20 ABCG5 APOB BCAM C19orf80 CBX1 COL4A3BP DHX38 DOCK7 EPOR FES FUT2 HPR IPO7 LDLR LPL NTN5 OPRL1 PAFAH1B2 PSRC1 PVRL2 RP11-686O6.2 TOMM40 ZNF259
Illnesses of mother 3.76 2 1 3.0 0.00 1.0e+00 ABCG5 FES
Forced expiratory volume in 1-second (FEV1), Best measure 1.17 3 0 0.0 0.00 1.0e+00 ABCG5 EPOR RP11-686O6.2
Impedance of arm (left) 0.97 3 0 0.0 0.00 1.0e+00 CBX1 COL4A3BP OPRL1
Arm fat mass (right) 1.59 3 2 6.1 0.00 1.0e+00 COL4A3BP DHX38 HPR
Trunk predicted mass 1.09 3 3 9.1 0.00 1.0e+00 COL4A3BP EPOR PSRC1
Standing height 0.85 6 3 9.1 -0.95 4.1e-03 ABCG5 CBX1 EPOR LPL PSRC1 RP11-686O6.2
Hair/balding pattern: Pattern 4 0.94 1 0 0.0 0.00 1.0e+00 RP11-686O6.2
Birth weight of first child 2.20 3 1 3.0 0.00 1.0e+00 EPOR FES OPRL1
Peak expiratory flow (PEF) 1.06 1 0 0.0 0.00 1.0e+00 NTN5
Headache pain in last month 1.15 1 0 0.0 0.00 1.0e+00 FES
Medication for cholesterol, blood pressure or diabetes 15.06 19 8 24.2 -0.97 1.4e-11 ABCG5 APOB BCAM C19orf80 CBX1 COL4A3BP DHX38 EPOR FES FUT2 HPR IPO7 LDLR NTN5 OPRL1 PAFAH1B2 PSRC1 TOMM40 ZNF259
Medication: Amlodipine 1.88 1 0 0.0 0.00 1.0e+00 FES
Birth weight 1.75 2 0 0.0 0.00 1.0e+00 FES FUT2
Chronic bronchitis/emphysema (mother) 1.53 1 0 0.0 0.00 1.0e+00 BCAM
High blood pressure (siblings) 2.74 1 1 3.0 0.00 1.0e+00 FES
Forced vital capacity (FVC), Best measure 1.32 3 0 0.0 0.00 1.0e+00 ABCG5 EPOR RP11-686O6.2
Body fat percentage 1.34 4 1 3.0 -0.42 5.8e-01 BCAM COL4A3BP DHX38 HPR
Leg fat percentage (right) 1.29 4 1 3.0 -0.42 5.8e-01 BCAM COL4A3BP DHX38 HPR
Arm fat-free mass (right) 1.07 3 1 3.0 0.00 1.0e+00 COL4A3BP EPOR PSRC1
Comparative body size at age 10 1.01 1 0 0.0 0.00 1.0e+00 NTN5
Medication: Blood pressure 4.47 4 1 3.0 0.91 9.2e-02 ABCG5 FES FUT2 OPRL1
Angina (self-reported) 7.56 6 2 6.1 0.98 7.0e-04 ABCG5 C19orf80 FES LPL OPRL1 PSRC1
Heart disease (mother) 2.96 2 0 0.0 0.00 1.0e+00 ABCG5 FES
Whole body fat mass 1.37 4 1 3.0 -0.26 7.4e-01 BCAM COL4A3BP DHX38 HPR
Leg fat mass (right) 1.47 4 1 3.0 -0.34 6.6e-01 BCAM COL4A3BP DHX38 HPR
Arm predicted mass (right) 1.06 3 1 3.0 0.00 1.0e+00 COL4A3BP EPOR PSRC1
Pulse rate, automated reading 1.59 3 0 0.0 0.00 1.0e+00 APOB BCAM FUT2
Alcohol intake frequency. 1.18 2 0 0.0 0.00 1.0e+00 FUT2 NTN5
Comparative height size at age 10 1.04 4 0 0.0 -0.89 1.1e-01 FUT2 IPO7 NTN5 PSRC1
Overall health rating 1.52 1 0 0.0 0.00 1.0e+00 ABCG5
Chest pain or discomfort 1.89 1 0 0.0 0.00 1.0e+00 NTN5
Medication: Aspirin 7.00 5 1 3.0 0.96 9.2e-03 C19orf80 EPOR FES OPRL1 PSRC1
Hypertension (Self-reported) 4.42 6 2 6.1 0.96 2.3e-03 ABCG5 CBX1 DHX38 FES NTN5 OPRL1
Illnesses of father: Heart disease 6.89 6 2 6.1 0.92 8.6e-03 ABCG5 EPOR FES LPL OPRL1 PSRC1
Whole body fat-free mass 1.07 3 2 6.1 0.00 1.0e+00 COL4A3BP EPOR PSRC1
Leg fat-free mass (right) 1.05 4 1 3.0 0.43 5.7e-01 COL4A3BP EPOR FES PSRC1
Arm fat percentage (left) 1.51 5 2 6.1 -0.12 8.4e-01 BCAM COL4A3BP DHX38 HPR RP11-686O6.2
Medication for cholesterol 7.64 10 1 3.0 -0.97 2.8e-06 COL4A3BP DHX38 DOCK7 FUT2 HPR LDLR NTN5 OPRL1 PAFAH1B2 PSRC1
Back pain experienced in last month 1.77 1 0 0.0 0.00 1.0e+00 APOB
Medication: Aspirin 7.25 6 1 3.0 0.97 1.3e-03 C19orf80 EPOR FES NTN5 OPRL1 PSRC1
Illnesses of father: None of the above (group 1) 3.90 2 1 3.0 0.00 1.0e+00 ABCG5 FES
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.27 1 0 0.0 0.00 1.0e+00 OPRL1
Whole body water mass 1.07 3 1 3.0 0.00 1.0e+00 COL4A3BP EPOR PSRC1
Leg predicted mass (right) 1.06 4 1 3.0 0.46 5.4e-01 COL4A3BP EPOR FES PSRC1
Arm fat mass (left) 1.53 3 2 6.1 0.00 1.0e+00 COL4A3BP DHX38 HPR
Number of self-reported non-cancer illnesses 5.04 6 0 0.0 0.93 7.9e-03 ABCG5 CBX1 DHX38 NTN5 OPRL1 PSRC1
Medication: Blood pressure 3.43 4 1 3.0 0.95 4.5e-02 CBX1 DHX38 FES OPRL1
High cholesterol (Self-reported) 53.25 23 21 63.6 0.98 9.6e-16 ABCG5 APOB BCAM C19orf80 CBX1 COL4A3BP DHX38 DOCK7 EPOR FES FUT2 HPR IPO7 LDLR LPL NTN5 OPRL1 PAFAH1B2 PSRC1 PVRL2 RP11-686O6.2 TOMM40 ZNF259
Medication: Bendroflumethiazide 2.05 1 0 0.0 0.00 1.0e+00 FES
Medication: Atorvastatin 20.66 14 8 24.2 0.98 7.0e-10 ABCG5 APOB BCAM C19orf80 COL4A3BP DOCK7 EPOR HPR LPL PAFAH1B2 PSRC1 PVRL2 TOMM40 ZNF259
Illnesses of father: High blood pressure 3.02 2 1 3.0 0.00 1.0e+00 ABCG5 FES
Basal metabolic rate 1.12 3 1 3.0 0.00 1.0e+00 COL4A3BP EPOR PSRC1
Leg fat percentage (left) 1.28 3 1 3.0 0.00 1.0e+00 BCAM COL4A3BP DHX38
Arm fat-free mass (left) 1.09 3 1 3.0 0.00 1.0e+00 COL4A3BP EPOR PSRC1
Age started oral contraceptive pill 0.76 1 0 0.0 0.00 1.0e+00 FES
Diastolic blood pressure, automated reading 2.53 2 1 3.0 0.00 1.0e+00 C19orf80 FES
Vascular/heart problems diagnosed by doctor 5.27 7 2 6.1 -0.93 2.1e-03 ABCG5 CBX1 DHX38 FES FUT2 NTN5 OPRL1
Cholesterol lowering medication 27.15 21 14 42.4 0.99 3.1e-18 ABCG5 APOB BCAM C19orf80 CBX1 COL4A3BP DHX38 DOCK7 EPOR FUT2 HPR LDLR LPL NTN5 OPRL1 PAFAH1B2 PSRC1 PVRL2 RP11-686O6.2 TOMM40 ZNF259
Heart attack/myocardial infarction (self-reported) 4.63 4 1 3.0 0.98 2.3e-02 C19orf80 FES NTN5 PSRC1
Heart disease (siblings) 3.22 3 0 0.0 0.00 1.0e+00 FES PSRC1 ZNF259
Impedance of whole body 1.10 5 2 6.1 -0.10 8.7e-01 CBX1 COL4A3BP LPL OPRL1 PSRC1
Leg fat mass (left) 1.44 4 1 3.0 -0.41 5.9e-01 BCAM COL4A3BP DHX38 HPR
Arm predicted mass (left) 1.10 3 2 6.1 0.00 1.0e+00 COL4A3BP EPOR PSRC1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.44
GTEx Adipose Visceral Omentum 1 0.0491 1.52
GTEx Adrenal Gland 0 0.0000 1.51
GTEx Artery Aorta 4 0.1344 1.51
GTEx Artery Coronary 0 0.0000 1.48
GTEx Artery Tibial 4 0.1064 1.51
GTEx Brain Caudate basal ganglia 0 0.0000 1.36
GTEx Brain Cerebellar Hemisphere 1 0.0672 1.44
GTEx Brain Cerebellum 1 0.0505 1.47
GTEx Brain Cortex 0 0.0000 1.42
GTEx Brain Frontal Cortex BA9 0 0.0000 1.45
GTEx Brain Hippocampus 0 0.0000 1.37
GTEx Brain Hypothalamus 0 0.0000 1.34
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.41
GTEx Brain Putamen basal ganglia 0 0.0000 1.28
GTEx Breast Mammary Tissue 0 0.0000 1.44
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.50
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.46
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.49
GTEx Cells Transformed fibroblasts 5 0.1191 1.50
GTEx Colon Sigmoid 0 0.0000 1.41
GTEx Colon Transverse 0 0.0000 1.44
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.42
GTEx Esophagus Mucosa 7 0.2108 1.52
GTEx Esophagus Muscularis 3 0.0928 1.45
GTEx Heart Atrial Appendage 0 0.0000 1.45
GTEx Heart Left Ventricle 0 0.0000 1.43
GTEx Liver 2 0.2789 1.72
GTEx Lung 0 0.0000 1.47
GTEx Muscle Skeletal 2 0.0692 1.52
GTEx Nerve Tibial 2 0.0463 1.41
GTEx Ovary 0 0.0000 1.49
GTEx Pancreas 2 0.1225 1.39
GTEx Pituitary 0 0.0000 1.43
GTEx Prostate 0 0.0000 1.48
GTEx Skin Not Sun Exposed Suprapubic 2 0.0813 1.45
GTEx Skin Sun Exposed Lower leg 4 0.1099 1.52
GTEx Small Intestine Terminal Ileum 0 0.0000 1.46
GTEx Spleen 1 0.0709 1.43
GTEx Stomach 2 0.1376 1.57
GTEx Testis 0 0.0000 1.48
GTEx Thyroid 1 0.0250 1.47
GTEx Uterus 0 0.0000 1.34
GTEx Vagina 1 0.1575 1.57
GTEx Whole Blood 4 0.2007 1.58
METSIM Adipose 2 0.0434 1.37
NTR Blood 2 0.0833 1.42
ROSMAP Brain Pre-frontal Cortex 6 0.1366 1.54
YFS Blood 6 0.1299 1.46
CommonMind Brain Pre-frontal Cortex 6 0.1116 1.51
TCGA Breast Tumor 0 0.0000 1.38
TCGA Breast Normal 3 0.0713 1.45
TCGA Ovarian Tumor 4 0.1369 1.39
TCGA Prostate Tumor 1 0.0289 1.41