Hub : Genes

IPO7

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0560 0.026 0.0043 0.031 0.023 0.019 0.026 0.016 1.1e-04 0.00069 0.0022 0.00038 0.0037
2 YFS Blood 0.0204 0.009 0.0014 0.013 0.008 0.003 0.008 0.007 3.4e-05 0.00071 0.0250 0.00093 0.0014

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.3 0.5 0.7 0.8 0.6
Bipolar Disorder or Schizophrenia 0.0 0.1 0.1 0.3 0.2
Depressed Affect (Nagel 2018) 0.2 0.5 0.8 0.3 -0.9
Depression (Nagel 2018) 0.1 0.1 0.2 -0.1 0.4
Intelligence (Savage-Jansen 2018) 0.7 2.0 2.1 -1.4 1.5
Neuroticism (Nagel 2018) 0.1 0.3 0.5 -0.7 -0.4
Schizophrenia (2018) 0.0 0.1 0.1 -0.2 -0.3
Schizophrenia vs Biploar Disorder 2.5 3.3 6.6 0.0 -2.6
Worry (Nagel 2018) 0.2 0.4 0.7 -0.4 0.8
Alzheimer’s Disease (in mother) 0.6 0.7 0.9 -1.0 0.7
Alzheimer’s Disease (in father) 0.1 0.1 0.2 -0.2 -0.4
Alzheimer’s Disease (including proxy) 1.0 1.5 1.8 -1.1 1.4
Crohns Disease (2017) 1.1 2.4 4.7 -2.2 -0.2
Irritable Bowel Disease (IBD) 1.2 2.9 5.3 -2.3 -0.8
Ulcerative Colitis (UC) 0.8 1.5 2.4 -1.6 -0.7
Major Depression (MDD) 0.2 0.2 0.5 -0.1 0.7
Reaction Time 0.1 0.1 0.2 0.2 -0.4
Verbal and Numeric Reasoning (VNR) 1.2 2.9 3.5 -1.9 1.5
Breast Cancer 0.0 0.1 0.1 -0.3 0.3
Ovarian Cancer 0.3 0.4 0.9 -0.0 0.9
Prostate Cancer 1.3 1.8 3.4 -0.5 -1.8
Age at First Birth 0.6 0.9 1.8 1.3 0.2
Bipolar Disorder (2011) 1.8 1.7 2.0 1.2 -1.4
Body Mass Index (BMI) (2010) 0.7 0.9 1.5 1.2 -0.6
Coronary Artery Disease (CAD) 0.1 0.1 0.2 0.5 -0.2
Crohns Disease (2012) 0.5 0.8 1.2 -1.1 0.6
Mean Putamen Volume 0.3 0.3 0.4 0.7 0.4
Fasting Glucose 0.1 0.1 0.1 -0.4 -0.3
HbA1C 0.9 1.0 1.3 -1.1 0.9
HDL Cholesterol 0.5 0.9 1.5 -0.5 1.2
LDL Cholesterol 0.9 1.4 2.9 -0.1 -1.7
Lupus 0.0 0.0 0.1 0.2 0.1
Neuroticism (2016) 1.9 2.8 4.5 -2.1 1.0
Primary Biliary Cirrhosis 0.2 0.3 0.5 -0.4 -0.7
Rheumatoid Arthritis 0.0 0.0 0.1 -0.2 -0.2
Schizophrenia (2014) 0.2 0.4 0.7 -0.4 -0.8
Triglycerides 0.4 0.6 1.2 0.1 -1.1
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.3 -0.3 -1.2
Ulcerative Colitis 0.2 0.3 0.5 -0.4 -0.7
Blood Eosinophil Count 0.4 2.8 3.8 1.9 -1.4
Blood Platelet Count 1.7 19.7 31.7 -2.8 5.6
Blood Red Count 0.3 2.9 5.8 2.4 -0.1
Blood White Count 1.1 8.2 11.2 -2.3 3.3
Heel T-Score 0.3 2.2 4.3 0.3 2.1
BMI 0.7 4.2 4.5 2.1 -2.0
Height 0.6 10.7 17.6 1.9 -4.2
Waist Hip Ratio (WHR) 0.8 3.6 4.4 -2.1 -1.7
Systolic Blood Pressure 2.0 9.9 19.7 -0.1 4.4
Smoking Status 0.4 0.9 1.0 -0.9 -1.0
Allergy or Eczema 0.8 2.1 3.6 0.7 -1.9
Cardiovascular Disease 3.1 10.2 13.7 -2.6 3.7
Hypothyroidism (self reported) 0.3 0.8 1.5 -0.1 1.2
Respiratory disease 0.9 2.1 2.4 1.6 -1.3
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.4 -0.6 -0.3
Lung FEV1/FVC ratio 0.2 0.8 1.2 0.6 -1.1
Lung FVC 0.6 3.2 5.4 -1.0 2.3
Neuroticism 0.4 1.0 2.0 -1.4 0.2
Chronotype (morning person) 1.2 2.7 2.7 -1.6 -1.6
Hair Pigment 0.0 0.3 0.6 -0.8 0.1
Tanning 0.2 2.5 4.5 0.6 2.1
Hand grip strength (left) 0.7 1.8 1.9 1.3 1.4
Number of treatments/medications taken 1.0 1.8 3.5 -1.9 -0.3
Average weekly spirits intake 0.4 0.5 0.7 0.5 -0.8
Sensitivity / hurt feelings 2.0 3.4 6.4 -2.5 0.5
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.3 0.6 -0.5
Hearing difficulty/problems: Yes 0.3 0.5 0.8 0.3 0.9
Relative age of first facial hair 0.1 0.2 0.5 -0.1 0.7
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.5 -1.2 -0.3
Ever used hormone-replacement therapy (HRT) 1.6 2.1 4.1 -2.0 -0.1
Ever had hysterectomy (womb removed) 0.7 0.8 1.0 -0.8 -1.0
Systolic blood pressure, automated reading 1.7 4.9 9.7 0.3 3.1
Eye problems/disorders: Diabetes related eye disease 0.9 0.9 1.9 0.1 1.4
Angina 1.6 2.1 3.4 -0.9 1.8
Medication for hormone replacement therapy 0.4 0.4 0.6 0.5 -0.8
Vitamin and mineral supplements 0.1 0.1 0.2 -0.0 0.5
Supplements: Zinc 0.5 0.6 0.9 0.5 -1.0
Medication: Co-codamol 0.0 0.0 0.1 0.3 0.2
Medication: Metformin 0.0 0.0 0.0 0.2 -0.2
Diabetes (father) 0.4 0.4 0.8 -0.2 0.9
Diabetes (mother) 0.4 0.5 0.9 -0.4 -0.9
Severe depression (siblings) 0.3 0.3 0.6 0.3 0.8
Pack years adult smoking proportion 0.5 0.8 1.4 -1.2 0.5
Impedance of leg (right) 0.3 1.3 1.9 -1.4 0.8
Leg fat-free mass (left) 1.3 7.0 9.2 2.2 -3.0
Trunk fat percentage 0.6 2.3 4.6 0.3 -2.1
Hand grip strength (right) 0.4 1.0 1.8 1.3 0.4
Townsend deprivation index at recruitment 0.2 0.3 0.6 -0.3 -0.8
Current tobacco smoking 0.2 0.3 0.5 -0.7 -0.4
Average weekly fortified wine intake 1.2 1.4 2.5 -0.6 1.6
Maternal smoking around birth 0.6 0.8 1.6 -1.3 -0.3
Fed-up feelings 1.1 2.1 4.1 -2.0 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.0 0.0 0.1 0.1 -0.2
Relative age voice broke 0.7 1.1 1.2 -1.1 1.1
Taking other prescription medications 0.5 0.8 0.9 -1.0 -0.8
Age when periods started (menarche) 0.7 1.8 2.5 1.6 -1.0
Bilateral oophorectomy (both ovaries removed) 0.6 0.6 0.7 -0.8 -0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 2.5 1.6 -0.9
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.8 0.9 -0.2
Qualifications: CSEs or equivalent 0.0 0.0 0.1 0.2 -0.1
Serious illness, injury or assault to yourself 0.0 0.0 0.0 0.1 -0.2
High blood pressure 0.7 1.9 3.3 -0.7 1.8
Hayfever, allergic rhinitis or eczema 1.1 2.4 4.5 0.5 -2.1
Multivitamins +/- minerals 0.4 0.5 0.9 0.9 -0.2
Stomach or abdominal pain in last month 0.9 1.1 2.0 -1.4 0.4
Supplements: Glucosamine 0.3 0.4 0.6 -0.3 -0.8
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 1.2 -1.1 1.1
Medication: Atenolol 1.9 2.4 3.4 -1.8 1.2
Medication: Levothyroxine sodium 0.2 0.4 0.7 -0.3 0.9
Sitting height 0.0 0.1 0.1 0.3 0.4
Chronic bronchitis/emphysema (father) 0.7 0.9 1.5 -1.2 0.4
High blood pressure (mother) 2.2 3.1 3.5 -1.7 1.9
Body mass index (BMI) 0.6 2.6 3.7 1.2 -1.9
Impedance of leg (left) 0.2 0.9 1.1 -1.1 0.8
Leg predicted mass (left) 1.3 7.1 9.3 2.2 -3.0
Trunk fat mass 1.0 4.4 7.5 1.1 -2.7
Waist circumference 0.8 3.0 4.9 1.0 -2.2
Number of incorrect matches in round 3.4 5.7 6.1 2.5 -2.3
Past tobacco smoking 0.7 1.2 2.0 0.7 1.4
Alcohol usually taken with meals 0.1 0.1 0.2 -0.5 -0.3
Nervous feelings 0.9 1.7 2.3 -1.1 1.5
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.5 2.2 -1.5 1.0
Hearing difficulty/problems with background noise 0.5 0.8 1.6 0.1 1.2
Hair/balding pattern: Pattern 2 2.6 3.2 6.5 -0.2 2.5
Had menopause 0.9 1.1 1.9 -1.4 0.5
Had other major operations 0.2 0.2 0.5 -0.7 0.2
Forced vital capacity (FVC) 0.0 0.1 0.1 0.3 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 1.3 1.1 -0.9
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 0.7 -0.5 0.8
Qualifications: None of the above 0.7 1.4 2.7 -0.4 -1.6
Financial difficulties in last 2 years 0.4 0.6 1.1 1.0 -0.3
Mouth/teeth dental problems 1.8 2.8 4.3 2.1 -1.1
Heart attack 0.7 0.9 1.1 -1.1 0.8
Allergy 1.7 3.9 6.5 -1.1 2.5
Pain all over the body in last month 1.7 1.9 2.0 1.4 -1.3
Diabetes (self-reported) 0.2 0.2 0.3 -0.5 0.5
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 0.6 -0.8 0.4
Medication: Ramipril 3.8 4.9 9.4 -3.1 0.6
Medication: Simvastatin 12.1 17.7 29.3 -5.4 2.5
Fluid intelligence score 0.1 0.2 0.3 0.2 0.6
Illnesses of siblings 0.6 0.9 1.4 1.2 -0.7
Neuroticism score 1.3 2.7 4.7 -2.2 0.8
Weight 1.8 8.9 11.4 2.5 -3.4
Impedance of arm (right) 0.1 0.5 0.8 -0.9 0.5
Arm fat percentage (right) 0.5 1.8 3.0 0.8 -1.7
Trunk fat-free mass 1.5 8.8 9.1 3.0 -2.9
Hip circumference 1.1 4.7 4.9 2.1 -2.2
Time employed in main current job 1.0 1.1 1.1 -1.0 1.1
Alcohol intake versus 10 years previously 0.3 0.5 0.9 1.0 -0.3
Father’s age at death 0.4 0.5 0.6 0.8 -0.7
Worrier / anxious feelings 1.3 2.5 2.5 -1.6 1.6
Frequency of tiredness / lethargy in last 2 weeks 2.2 3.6 7.3 -2.7 0.2
Falls in the last year 4.6 6.3 12.5 -3.5 0.1
Hair/balding pattern: Pattern 3 0.6 0.9 1.0 0.9 -1.0
Number of live births 0.9 1.2 1.7 -1.3 -0.9
Forced expiratory volume in 1-second (FEV1) 0.0 0.0 0.0 -0.2 0.1
Pulse rate 0.2 0.4 0.7 -0.8 0.1
Happiness 0.0 0.0 0.1 0.1 0.3
Noisy workplace 1.2 1.5 1.8 1.1 -1.3
Qualifications: A levels/AS levels or equivalent 0.9 1.9 3.4 -0.6 1.9
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.3 -0.6 0.4
Mouth/teeth dental problems: Dentures 1.9 3.2 5.9 -2.4 0.7
Asthma 0.1 0.2 0.3 -0.6 -0.2
Medication: Ibuprofen (e.g. Nurofen) 1.9 2.4 4.8 -0.0 -2.2
Medication: Cholesterol lowering 6.5 10.1 16.9 -4.1 1.8
Depression (self-reported) 2.4 2.8 4.2 -1.2 2.1
Medication: Lansoprazole 0.7 0.8 1.5 0.4 -1.2
Prospective memory result 0.6 0.7 1.1 0.6 1.0
Lung cancer (father) 0.4 0.4 0.8 0.9 -0.1
Illnesses of mother 1.1 1.4 2.7 1.6 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 0.3 0.6 0.1
Pulse wave Arterial Stiffness index 0.3 0.4 0.4 -0.6 0.6
Impedance of arm (left) 0.2 1.1 1.9 -1.4 0.6
Arm fat mass (right) 1.2 4.8 8.0 1.3 -2.8
Trunk predicted mass 1.5 8.4 8.6 2.9 -2.9
Standing height 1.0 9.8 12.1 2.8 -3.5
Length of working week for main job 0.3 0.3 0.5 -0.7 -0.3
Exposure to tobacco smoke at home 0.4 0.4 0.8 0.2 -0.9
Breastfed as a baby 3.8 4.7 4.7 2.2 -2.2
Tense / ‘highly strung’ 1.0 1.7 2.0 -1.4 1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.3 -0.7 1.2
Hair/balding pattern: Pattern 4 0.4 0.9 1.7 0.2 -1.3
Birth weight of first child 0.1 0.1 0.3 -0.1 -0.5
Peak expiratory flow (PEF) 0.2 0.4 0.8 0.1 -0.9
Pulse wave reflection index 0.1 0.1 0.1 0.4 -0.2
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.1 -0.1 0.4
Loud music exposure frequency 0.1 0.2 0.3 0.1 -0.5
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 0.7 0.8 0.7
Mouth/teeth dental problems: Bleeding gums 0.7 1.0 1.7 -0.5 1.3
Blood clot in the leg (DVT) 1.0 1.3 2.3 1.5 -0.5
Medication: Paracetamol 0.3 0.6 1.1 -0.1 -1.1
Headache pain in last month 0.6 1.1 1.7 -1.3 0.7
Medication for cholesterol, blood pressure or diabetes 4.5 7.4 12.9 3.6 -1.4
Glaucoma (self-reported) 1.9 2.2 2.4 1.4 -1.5
Gout (self-reported) 1.6 2.1 2.5 1.6 -1.3
Hypothyroidism/myxoedema (self-reported) 0.0 0.0 0.1 0.2 0.2
Medication: Amlodipine 0.1 0.2 0.3 -0.5 0.1
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.2 -0.3 0.4
Birth weight 1.0 2.2 2.7 -1.6 1.3
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.3 -0.6 -0.6
High blood pressure (siblings) 0.0 0.0 0.0 0.0 0.0
Forced vital capacity (FVC), Best measure 0.1 0.2 0.4 0.6 -0.3
Body fat percentage 0.7 2.7 5.0 0.6 -2.2
Leg fat percentage (right) 0.5 1.7 3.2 0.5 -1.8
Arm fat-free mass (right) 1.4 7.1 8.6 2.4 -2.9
Exposure to tobacco smoke outside home 1.0 1.3 2.0 0.8 -1.4
Comparative body size at age 10 0.1 0.2 0.3 0.5 0.2
Number of full brothers 1.8 2.3 3.0 1.3 1.7
Worry too long after embarrassment 4.2 7.1 9.0 -3.0 2.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.2 -0.1 -0.4
Wheeze or whistling in the chest in last year 0.1 0.2 0.4 -0.1 -0.6
Number of children fathered 0.0 0.0 0.1 -0.0 0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 0.9 0.9 0.2
Age at first live birth 0.7 1.2 1.9 1.4 0.7
Pulse wave peak to peak time 0.4 0.5 0.6 0.6 -0.7
Health satisfaction 1.8 2.4 4.7 -2.2 0.1
Shortness of breath walking on level ground 0.1 0.1 0.1 -0.2 0.4
Qualifications: College or University degree 2.5 8.0 12.0 -2.0 3.5
Eye problems/disorders: None of the above 0.5 0.6 1.2 -1.1 -0.0
Mouth/teeth dental problems: Loose teeth 0.3 0.4 0.6 -0.5 -0.8
Emphysema/chronic bronchitis 0.6 0.7 1.2 0.4 -1.1
Medication for pain relief, constipation, heartburn 1.2 2.1 2.5 1.3 1.6
Neck or shoulder pain in last month 0.2 0.2 0.3 -0.4 -0.5
Medication: Blood pressure 1.9 3.4 4.5 -2.1 1.5
Angina (self-reported) 2.2 2.9 4.2 -1.2 2.1
Migraine (self-reported) 2.6 3.2 6.3 -2.5 -0.0
Medication: Ibuprofen 1.5 1.8 3.5 0.2 -1.9
Medication: Allopurinol 0.5 0.6 0.7 0.7 -0.8
Medication: Omeprazole 0.1 0.1 0.2 -0.4 0.1
Medication: Seretide 50 evohaler 0.4 0.4 0.5 0.7 -0.6
Mean time to correctly identify matches 0.9 1.7 2.4 1.0 -1.5
Heart disease (mother) 0.9 1.1 1.2 -1.1 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 2.8 0.2 1.7
Whole body fat mass 1.1 4.5 7.2 1.3 -2.7
Leg fat mass (right) 1.0 3.8 6.2 1.2 -2.5
Arm predicted mass (right) 1.4 7.3 9.2 2.3 -3.0
Pulse rate, automated reading 0.1 0.3 0.5 -0.7 -0.3
Alcohol intake frequency. 0.0 0.1 0.2 -0.2 -0.4
Comparative height size at age 10 2.8 15.2 20.8 4.6 -3.1
Number of full sisters 0.1 0.1 0.2 -0.5 -0.2
Suffer from ‘nerves’ 0.0 0.1 0.1 -0.3 -0.2
Overall health rating 0.6 1.3 2.6 -1.6 0.0
Chest pain or discomfort 2.5 3.7 5.0 -1.5 2.2
Had major operations 0.0 0.1 0.1 -0.1 0.3
Age at last live birth 0.8 1.1 2.2 1.5 -0.2
Family relationship satisfaction 0.7 0.9 1.6 -1.2 0.4
Leg pain on walking 0.0 0.0 0.0 0.0 -0.1
Qualifications: NVQ or HND or HNC or equivalent 0.0 0.0 0.0 -0.1 -0.0
Commuting to job workplace: Car/motor vehicle 0.7 0.8 1.3 1.1 -0.6
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 1.1 1.0 -0.6
Medication: Aspirin 3.4 4.5 7.1 -2.7 1.4
Supplements: Vitamin C 0.0 0.0 0.0 -0.1 -0.0
Knee pain experienced in last month 0.1 0.1 0.2 -0.5 0.0
Hypertension (Self-reported) 0.6 1.7 2.7 -0.9 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 0.8 0.2 0.9
Illnesses of father: Heart disease 1.9 2.6 2.9 -1.5 1.7
Illnesses of siblings: Diabetes 0.4 0.5 0.9 0.4 -0.9
Smoking status: Previous 0.5 0.7 1.3 0.2 -1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.4 -0.2 -0.6
Whole body fat-free mass 1.5 8.4 8.9 2.8 -3.0
Leg fat-free mass (right) 1.4 7.4 9.1 2.4 -3.0
Arm fat percentage (left) 0.4 1.7 3.2 0.5 -1.8
Average weekly red wine intake 0.0 0.1 0.1 -0.2 -0.3
Handedness (chirality/laterality): Left-handed 0.4 0.5 0.8 0.5 -0.9
Mood swings 0.2 0.4 0.6 -0.8 -0.5
Loneliness, isolation 1.2 1.6 1.9 1.4 -1.1
Long-standing illness, disability or infirmity 0.9 1.3 2.0 -1.4 -0.8
Ever had bowel cancer screening 1.3 1.5 2.8 0.3 -1.7
Diabetes diagnosed by doctor 0.2 0.2 0.5 -0.7 -0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.2 0.4 -0.4
Friendships satisfaction 0.0 0.0 0.0 -0.2 -0.2
Qualifications: nursing, teaching 0.2 0.3 0.4 0.4 0.7
Commuting to job workplace: Walk 0.1 0.1 0.1 0.0 -0.3
Eye problems/disorders: Cataract 0.5 0.6 0.7 0.7 -0.8
Mouth/teeth dental problems: Mouth ulcers 0.0 0.1 0.1 0.1 -0.3
Medication for cholesterol 0.7 1.1 1.2 1.1 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.2 0.3 0.6 -0.1
Back pain experienced in last month 0.0 0.0 0.0 0.1 -0.0
Mineral and other dietary supplements 0.4 0.6 0.9 -0.4 1.0
Breast cancer (self-reported) 0.5 0.6 1.2 0.2 -1.1
Asthma (self-reported) 0.1 0.2 0.3 -0.5 -0.2
Osteoporosis (self-reported) 1.2 1.5 2.4 -0.8 -1.5
Osteoarthritis (self-reported) 0.3 0.4 0.6 0.4 -0.8
Medication: Aspirin 3.7 4.8 6.5 -2.5 1.7
Medication: Gliclazide 1.1 1.2 2.1 0.6 -1.5
Illnesses of father: None of the above (group 1) 4.9 6.0 7.5 2.1 -2.7
Smoking status: Current 0.4 0.6 0.7 -0.8 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.8 2.0 -1.3 1.4
Whole body water mass 1.5 8.7 9.2 2.9 -3.0
Leg predicted mass (right) 1.4 7.5 8.9 2.5 -3.0
Arm fat mass (left) 0.9 3.9 6.3 1.2 -2.5
Number of self-reported non-cancer illnesses 1.7 2.9 5.3 -2.3 0.7
Average weekly champagne plus white wine intake 0.2 0.3 0.3 -0.6 0.5
Miserableness 0.1 0.1 0.2 -0.4 -0.0
Guilty feelings 1.4 2.1 3.3 -1.8 0.9
Wears glasses or contact lenses 3.7 4.3 7.2 -2.7 1.2
Ever taken oral contraceptive pill 1.2 1.3 2.6 -1.6 0.2
Hearing aid user 0.5 0.6 0.9 -0.9 -0.6
Mother’s age at death 1.6 2.1 2.2 1.4 -1.5
Financial situation satisfaction 0.1 0.2 0.3 -0.0 -0.6
Tinnitus: Yes, now most or all of the time 0.0 0.1 0.1 0.2 0.3
Commuting to job workplace: Public transport 0.1 0.1 0.2 0.0 0.5
Eye problems/disorders: Glaucoma 1.4 1.7 2.6 0.9 -1.6
Medication: Blood pressure 0.1 0.3 0.5 -0.7 0.2
Pain type(s) experienced in last month: Hip pain 1.1 1.3 2.5 -0.4 -1.6
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.2 0.6 -1.1
High cholesterol (Self-reported) 6.6 11.7 13.2 -3.6 3.2
Medication: Bendroflumethiazide 0.1 0.1 0.2 -0.4 0.2
Medication: Paracetamol 0.6 0.9 1.3 0.7 -1.2
Medication: Lisinopril 0.7 0.9 1.7 -0.4 1.3
Medication: Atorvastatin 0.1 0.1 0.1 -0.3 0.3
Illnesses of father: High blood pressure 1.4 1.8 2.7 -0.9 1.7
Alcohol drinker status: Never 0.1 0.1 0.2 -0.1 0.5
Ever smoked 0.2 0.4 0.7 -0.4 -0.8
Basal metabolic rate 1.6 9.1 10.6 2.8 -3.2
Leg fat percentage (left) 0.6 2.0 3.6 0.6 -1.9
Arm fat-free mass (left) 1.5 7.5 9.0 2.5 -3.0
Number of operations (self-reported) 1.2 1.7 3.5 -1.9 0.1
Average weekly beer plus cider intake 2.2 3.1 5.2 2.3 -1.0
Irritability 1.2 2.1 4.1 -0.2 -2.0
Risk taking 0.3 0.4 0.7 -0.2 -0.9
Ever had prostate specific antigen (PSA) test 0.4 0.4 0.7 -0.8 0.4
Fractured/broken bones in last 5 years 3.1 3.9 5.0 -2.2 1.7
Age started oral contraceptive pill 0.7 0.9 1.1 0.9 1.0
Diastolic blood pressure, automated reading 0.6 2.0 3.8 0.5 1.9
Ever depressed for a whole week 0.8 1.0 1.3 -0.9 1.1
Unable to work because of sickness or disability 0.3 0.4 0.4 -0.5 -0.6
Commuting to job workplace: Cycle 3.5 4.3 6.9 -2.6 1.3
Myopia 1.8 2.6 3.8 -2.0 -1.1
Vascular/heart problems diagnosed by doctor 1.0 2.7 3.8 1.2 -1.9
Cholesterol lowering medication 3.8 5.5 8.2 -2.9 1.7
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.2 -0.5 -0.2
Pain experienced in last month 1.2 1.9 3.5 1.9 -0.6
Supplements: Calcium 1.9 2.1 2.7 -1.6 1.2
Basal cell carcinoma (self-reported) 1.0 1.1 2.3 -1.5 0.1
Heart attack/myocardial infarction (self-reported) 0.7 0.9 0.9 -1.0 0.9
Deep venous thrombosis (DVT) (self-reported) 0.7 0.8 1.6 1.3 -0.2
Heart disease (siblings) 0.1 0.1 0.2 -0.4 -0.1
Alcohol drinker status: Previous 1.4 1.6 1.8 -1.4 -1.2
Pack years of smoking 0.4 0.6 1.0 -1.0 0.4
Impedance of whole body 0.3 1.4 2.0 -1.4 0.9
Leg fat mass (left) 1.0 4.1 6.6 1.3 -2.6
Arm predicted mass (left) 1.4 7.0 8.1 2.5 -2.8