TWAS hub - IPO7

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0560	0.026	0.0043	0.031	0.023	0.019	0.026	0.016	1.1e-04	0.00069	0.0022	0.00038	0.0037
2	YFS	Blood	0.0204	0.009	0.0014	0.013	0.008	0.003	0.008	0.007	3.4e-05	0.00071	0.0250	0.00093	0.0014

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Medication: Simvastatin	12.1	17.7	29.3	-5.4	2.5
High cholesterol (Self-reported)	6.6	11.7	13.2	-3.6	3.2
Medication: Cholesterol lowering	6.5	10.1	16.9	-4.1	1.8
Illnesses of father: None of the above (group 1)	4.9	6.0	7.5	2.1	-2.7
Falls in the last year	4.6	6.3	12.5	-3.5	0.1
Medication for cholesterol, blood pressure or diabetes	4.5	7.4	12.9	3.6	-1.4
Worry too long after embarrassment	4.2	7.1	9.0	-3.0	2.3
Medication: Ramipril	3.8	4.9	9.4	-3.1	0.6
Breastfed as a baby	3.8	4.7	4.7	2.2	-2.2
Cholesterol lowering medication	3.8	5.5	8.2	-2.9	1.7
Medication: Aspirin	3.7	4.8	6.5	-2.5	1.7
Wears glasses or contact lenses	3.7	4.3	7.2	-2.7	1.2
Commuting to job workplace: Cycle	3.5	4.3	6.9	-2.6	1.3
Number of incorrect matches in round	3.4	5.7	6.1	2.5	-2.3
Medication: Aspirin	3.4	4.5	7.1	-2.7	1.4
Cardiovascular Disease	3.1	10.2	13.7	-2.6	3.7
Fractured/broken bones in last 5 years	3.1	3.9	5.0	-2.2	1.7
Comparative height size at age 10	2.8	15.2	20.8	4.6	-3.1
Hair/balding pattern: Pattern 2	2.6	3.2	6.5	-0.2	2.5
Migraine (self-reported)	2.6	3.2	6.3	-2.5	-0.0
Schizophrenia vs Biploar Disorder	2.5	3.3	6.6	0.0	-2.6
Qualifications: College or University degree	2.5	8.0	12.0	-2.0	3.5
Chest pain or discomfort	2.5	3.7	5.0	-1.5	2.2
Depression (self-reported)	2.4	2.8	4.2	-1.2	2.1
High blood pressure (mother)	2.2	3.1	3.5	-1.7	1.9
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.6	7.3	-2.7	0.2
Angina (self-reported)	2.2	2.9	4.2	-1.2	2.1
Average weekly beer plus cider intake	2.2	3.1	5.2	2.3	-1.0
Systolic Blood Pressure	2.0	9.9	19.7	-0.1	4.4
Sensitivity / hurt feelings	2.0	3.4	6.4	-2.5	0.5
Neuroticism (2016)	1.9	2.8	4.5	-2.1	1.0
Medication: Atenolol	1.9	2.4	3.4	-1.8	1.2
Mouth/teeth dental problems: Dentures	1.9	3.2	5.9	-2.4	0.7
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	4.8	-0.0	-2.2
Glaucoma (self-reported)	1.9	2.2	2.4	1.4	-1.5
Medication: Blood pressure	1.9	3.4	4.5	-2.1	1.5
Illnesses of father: Heart disease	1.9	2.6	2.9	-1.5	1.7
Supplements: Calcium	1.9	2.1	2.7	-1.6	1.2
Bipolar Disorder (2011)	1.8	1.7	2.0	1.2	-1.4
Mouth/teeth dental problems	1.8	2.8	4.3	2.1	-1.1
Weight	1.8	8.9	11.4	2.5	-3.4
Number of full brothers	1.8	2.3	3.0	1.3	1.7
Health satisfaction	1.8	2.4	4.7	-2.2	0.1
Myopia	1.8	2.6	3.8	-2.0	-1.1
Blood Platelet Count	1.7	19.7	31.7	-2.8	5.6
Systolic blood pressure, automated reading	1.7	4.9	9.7	0.3	3.1
Allergy	1.7	3.9	6.5	-1.1	2.5
Pain all over the body in last month	1.7	1.9	2.0	1.4	-1.3
Number of self-reported non-cancer illnesses	1.7	2.9	5.3	-2.3	0.7
Ever used hormone-replacement therapy (HRT)	1.6	2.1	4.1	-2.0	-0.1
Angina	1.6	2.1	3.4	-0.9	1.8
Gout (self-reported)	1.6	2.1	2.5	1.6	-1.3
Mother’s age at death	1.6	2.1	2.2	1.4	-1.5
Basal metabolic rate	1.6	9.1	10.6	2.8	-3.2
Trunk fat-free mass	1.5	8.8	9.1	3.0	-2.9
Trunk predicted mass	1.5	8.4	8.6	2.9	-2.9
Medication: Ibuprofen	1.5	1.8	3.5	0.2	-1.9
Whole body fat-free mass	1.5	8.4	8.9	2.8	-3.0
Whole body water mass	1.5	8.7	9.2	2.9	-3.0
Arm fat-free mass (left)	1.5	7.5	9.0	2.5	-3.0
Arm fat-free mass (right)	1.4	7.1	8.6	2.4	-2.9
Arm predicted mass (right)	1.4	7.3	9.2	2.3	-3.0
Leg fat-free mass (right)	1.4	7.4	9.1	2.4	-3.0
Leg predicted mass (right)	1.4	7.5	8.9	2.5	-3.0
Guilty feelings	1.4	2.1	3.3	-1.8	0.9
Eye problems/disorders: Glaucoma	1.4	1.7	2.6	0.9	-1.6
Illnesses of father: High blood pressure	1.4	1.8	2.7	-0.9	1.7
Alcohol drinker status: Previous	1.4	1.6	1.8	-1.4	-1.2
Arm predicted mass (left)	1.4	7.0	8.1	2.5	-2.8
Prostate Cancer	1.3	1.8	3.4	-0.5	-1.8
Leg fat-free mass (left)	1.3	7.0	9.2	2.2	-3.0
Leg predicted mass (left)	1.3	7.1	9.3	2.2	-3.0
Neuroticism score	1.3	2.7	4.7	-2.2	0.8
Worrier / anxious feelings	1.3	2.5	2.5	-1.6	1.6
Ever had bowel cancer screening	1.3	1.5	2.8	0.3	-1.7
Irritable Bowel Disease (IBD)	1.2	2.9	5.3	-2.3	-0.8
Verbal and Numeric Reasoning (VNR)	1.2	2.9	3.5	-1.9	1.5
Chronotype (morning person)	1.2	2.7	2.7	-1.6	-1.6
Average weekly fortified wine intake	1.2	1.4	2.5	-0.6	1.6
Noisy workplace	1.2	1.5	1.8	1.1	-1.3
Arm fat mass (right)	1.2	4.8	8.0	1.3	-2.8
Medication for pain relief, constipation, heartburn	1.2	2.1	2.5	1.3	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	2.8	0.2	1.7
Loneliness, isolation	1.2	1.6	1.9	1.4	-1.1
Osteoporosis (self-reported)	1.2	1.5	2.4	-0.8	-1.5
Ever taken oral contraceptive pill	1.2	1.3	2.6	-1.6	0.2
Number of operations (self-reported)	1.2	1.7	3.5	-1.9	0.1
Irritability	1.2	2.1	4.1	-0.2	-2.0
Pain experienced in last month	1.2	1.9	3.5	1.9	-0.6
Crohns Disease (2017)	1.1	2.4	4.7	-2.2	-0.2
Blood White Count	1.1	8.2	11.2	-2.3	3.3
Fed-up feelings	1.1	2.1	4.1	-2.0	-0.2
Hayfever, allergic rhinitis or eczema	1.1	2.4	4.5	0.5	-2.1
Hip circumference	1.1	4.7	4.9	2.1	-2.2
Illnesses of mother	1.1	1.4	2.7	1.6	-0.3
Whole body fat mass	1.1	4.5	7.2	1.3	-2.7
Medication: Gliclazide	1.1	1.2	2.1	0.6	-1.5
Pain type(s) experienced in last month: Hip pain	1.1	1.3	2.5	-0.4	-1.6
Alzheimer’s Disease (including proxy)	1.0	1.5	1.8	-1.1	1.4
Number of treatments/medications taken	1.0	1.8	3.5	-1.9	-0.3
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	1.2	-1.1	1.1
Trunk fat mass	1.0	4.4	7.5	1.1	-2.7
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	2.2	-1.5	1.0
Time employed in main current job	1.0	1.1	1.1	-1.0	1.1
Standing height	1.0	9.8	12.1	2.8	-3.5
Tense / ‘highly strung’	1.0	1.7	2.0	-1.4	1.2
Blood clot in the leg (DVT)	1.0	1.3	2.3	1.5	-0.5
Birth weight	1.0	2.2	2.7	-1.6	1.3
Exposure to tobacco smoke outside home	1.0	1.3	2.0	0.8	-1.4
Leg fat mass (right)	1.0	3.8	6.2	1.2	-2.5
Vascular/heart problems diagnosed by doctor	1.0	2.7	3.8	1.2	-1.9
Basal cell carcinoma (self-reported)	1.0	1.1	2.3	-1.5	0.1
Leg fat mass (left)	1.0	4.1	6.6	1.3	-2.6
HbA1C	0.9	1.0	1.3	-1.1	0.9
LDL Cholesterol	0.9	1.4	2.9	-0.1	-1.7
Respiratory disease	0.9	2.1	2.4	1.6	-1.3
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	1.9	0.1	1.4
Stomach or abdominal pain in last month	0.9	1.1	2.0	-1.4	0.4
Nervous feelings	0.9	1.7	2.3	-1.1	1.5
Had menopause	0.9	1.1	1.9	-1.4	0.5
Number of live births	0.9	1.2	1.7	-1.3	-0.9
Qualifications: A levels/AS levels or equivalent	0.9	1.9	3.4	-0.6	1.9
Mean time to correctly identify matches	0.9	1.7	2.4	1.0	-1.5
Heart disease (mother)	0.9	1.1	1.2	-1.1	-1.0
Long-standing illness, disability or infirmity	0.9	1.3	2.0	-1.4	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	2.0	-1.3	1.4
Arm fat mass (left)	0.9	3.9	6.3	1.2	-2.5
Ulcerative Colitis (UC)	0.8	1.5	2.4	-1.6	-0.7
Waist Hip Ratio (WHR)	0.8	3.6	4.4	-2.1	-1.7
Allergy or Eczema	0.8	2.1	3.6	0.7	-1.9
Waist circumference	0.8	3.0	4.9	1.0	-2.2
Age at last live birth	0.8	1.1	2.2	1.5	-0.2
Ever depressed for a whole week	0.8	1.0	1.3	-0.9	1.1
Intelligence (Savage-Jansen 2018)	0.7	2.0	2.1	-1.4	1.5
Body Mass Index (BMI) (2010)	0.7	0.9	1.5	1.2	-0.6
BMI	0.7	4.2	4.5	2.1	-2.0
Hand grip strength (left)	0.7	1.8	1.9	1.3	1.4
Ever had hysterectomy (womb removed)	0.7	0.8	1.0	-0.8	-1.0
Relative age voice broke	0.7	1.1	1.2	-1.1	1.1
Age when periods started (menarche)	0.7	1.8	2.5	1.6	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	2.5	1.6	-0.9
High blood pressure	0.7	1.9	3.3	-0.7	1.8
Chronic bronchitis/emphysema (father)	0.7	0.9	1.5	-1.2	0.4
Past tobacco smoking	0.7	1.2	2.0	0.7	1.4
Qualifications: None of the above	0.7	1.4	2.7	-0.4	-1.6
Heart attack	0.7	0.9	1.1	-1.1	0.8
Medication: Lansoprazole	0.7	0.8	1.5	0.4	-1.2
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	1.7	-0.5	1.3
Body fat percentage	0.7	2.7	5.0	0.6	-2.2
Age at first live birth	0.7	1.2	1.9	1.4	0.7
Family relationship satisfaction	0.7	0.9	1.6	-1.2	0.4
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.3	1.1	-0.6
Medication for cholesterol	0.7	1.1	1.2	1.1	-1.0
Medication: Lisinopril	0.7	0.9	1.7	-0.4	1.3
Age started oral contraceptive pill	0.7	0.9	1.1	0.9	1.0
Heart attack/myocardial infarction (self-reported)	0.7	0.9	0.9	-1.0	0.9
Deep venous thrombosis (DVT) (self-reported)	0.7	0.8	1.6	1.3	-0.2
Alzheimer’s Disease (in mother)	0.6	0.7	0.9	-1.0	0.7
Age at First Birth	0.6	0.9	1.8	1.3	0.2
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.3	-0.3	-1.2
Height	0.6	10.7	17.6	1.9	-4.2
Lung FVC	0.6	3.2	5.4	-1.0	2.3
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.5	-1.2	-0.3
Trunk fat percentage	0.6	2.3	4.6	0.3	-2.1
Maternal smoking around birth	0.6	0.8	1.6	-1.3	-0.3
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	0.7	-0.8	-0.8
Body mass index (BMI)	0.6	2.6	3.7	1.2	-1.9
Illnesses of siblings	0.6	0.9	1.4	1.2	-0.7
Hair/balding pattern: Pattern 3	0.6	0.9	1.0	0.9	-1.0
Prospective memory result	0.6	0.7	1.1	0.6	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.3	-0.7	1.2
Headache pain in last month	0.6	1.1	1.7	-1.3	0.7
Emphysema/chronic bronchitis	0.6	0.7	1.2	0.4	-1.1
Overall health rating	0.6	1.3	2.6	-1.6	0.0
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.1	1.0	-0.6
Hypertension (Self-reported)	0.6	1.7	2.7	-0.9	1.6
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.2	0.6	-1.1
Medication: Paracetamol	0.6	0.9	1.3	0.7	-1.2
Leg fat percentage (left)	0.6	2.0	3.6	0.6	-1.9
Diastolic blood pressure, automated reading	0.6	2.0	3.8	0.5	1.9
Crohns Disease (2012)	0.5	0.8	1.2	-1.1	0.6
HDL Cholesterol	0.5	0.9	1.5	-0.5	1.2
Supplements: Zinc	0.5	0.6	0.9	0.5	-1.0
Pack years adult smoking proportion	0.5	0.8	1.4	-1.2	0.5
Taking other prescription medications	0.5	0.8	0.9	-1.0	-0.8
Hearing difficulty/problems with background noise	0.5	0.8	1.6	0.1	1.2
Arm fat percentage (right)	0.5	1.8	3.0	0.8	-1.7
Leg fat percentage (right)	0.5	1.7	3.2	0.5	-1.8
Eye problems/disorders: None of the above	0.5	0.6	1.2	-1.1	-0.0
Medication: Allopurinol	0.5	0.6	0.7	0.7	-0.8
Smoking status: Previous	0.5	0.7	1.3	0.2	-1.2
Eye problems/disorders: Cataract	0.5	0.6	0.7	0.7	-0.8
Breast cancer (self-reported)	0.5	0.6	1.2	0.2	-1.1
Hearing aid user	0.5	0.6	0.9	-0.9	-0.6
Triglycerides	0.4	0.6	1.2	0.1	-1.1
Blood Eosinophil Count	0.4	2.8	3.8	1.9	-1.4
Smoking Status	0.4	0.9	1.0	-0.9	-1.0
Neuroticism	0.4	1.0	2.0	-1.4	0.2
Average weekly spirits intake	0.4	0.5	0.7	0.5	-0.8
Medication for hormone replacement therapy	0.4	0.4	0.6	0.5	-0.8
Diabetes (father)	0.4	0.4	0.8	-0.2	0.9
Diabetes (mother)	0.4	0.5	0.9	-0.4	-0.9
Hand grip strength (right)	0.4	1.0	1.8	1.3	0.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.8	0.9	-0.2
Multivitamins +/- minerals	0.4	0.5	0.9	0.9	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	1.3	1.1	-0.9
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.7	-0.5	0.8
Financial difficulties in last 2 years	0.4	0.6	1.1	1.0	-0.3
Father’s age at death	0.4	0.5	0.6	0.8	-0.7
Lung cancer (father)	0.4	0.4	0.8	0.9	-0.1
Exposure to tobacco smoke at home	0.4	0.4	0.8	0.2	-0.9
Hair/balding pattern: Pattern 4	0.4	0.9	1.7	0.2	-1.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	0.7	0.8	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.9	0.9	0.2
Pulse wave peak to peak time	0.4	0.5	0.6	0.6	-0.7
Medication: Seretide 50 evohaler	0.4	0.4	0.5	0.7	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.8	0.2	0.9
Illnesses of siblings: Diabetes	0.4	0.5	0.9	0.4	-0.9
Arm fat percentage (left)	0.4	1.7	3.2	0.5	-1.8
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.8	0.5	-0.9
Mineral and other dietary supplements	0.4	0.6	0.9	-0.4	1.0
Smoking status: Current	0.4	0.6	0.7	-0.8	-0.8
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.7	-0.8	0.4
Pack years of smoking	0.4	0.6	1.0	-1.0	0.4
Bipolar Disorder (2018)	0.3	0.5	0.7	0.8	0.6
Ovarian Cancer	0.3	0.4	0.9	-0.0	0.9
Mean Putamen Volume	0.3	0.3	0.4	0.7	0.4
Blood Red Count	0.3	2.9	5.8	2.4	-0.1
Heel T-Score	0.3	2.2	4.3	0.3	2.1
Hypothyroidism (self reported)	0.3	0.8	1.5	-0.1	1.2
Hearing difficulty/problems: Yes	0.3	0.5	0.8	0.3	0.9
Severe depression (siblings)	0.3	0.3	0.6	0.3	0.8
Impedance of leg (right)	0.3	1.3	1.9	-1.4	0.8
Supplements: Glucosamine	0.3	0.4	0.6	-0.3	-0.8
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.6	-0.8	0.4
Alcohol intake versus 10 years previously	0.3	0.5	0.9	1.0	-0.3
Pulse wave Arterial Stiffness index	0.3	0.4	0.4	-0.6	0.6
Length of working week for main job	0.3	0.3	0.5	-0.7	-0.3
Medication: Paracetamol	0.3	0.6	1.1	-0.1	-1.1
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.3	-0.6	-0.6
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.6	-0.5	-0.8
Osteoarthritis (self-reported)	0.3	0.4	0.6	0.4	-0.8
Risk taking	0.3	0.4	0.7	-0.2	-0.9
Unable to work because of sickness or disability	0.3	0.4	0.4	-0.5	-0.6
Impedance of whole body	0.3	1.4	2.0	-1.4	0.9
Depressed Affect (Nagel 2018)	0.2	0.5	0.8	0.3	-0.9
Worry (Nagel 2018)	0.2	0.4	0.7	-0.4	0.8
Major Depression (MDD)	0.2	0.2	0.5	-0.1	0.7
Primary Biliary Cirrhosis	0.2	0.3	0.5	-0.4	-0.7
Schizophrenia (2014)	0.2	0.4	0.7	-0.4	-0.8
Ulcerative Colitis	0.2	0.3	0.5	-0.4	-0.7
Lung FEV1/FVC ratio	0.2	0.8	1.2	0.6	-1.1
Tanning	0.2	2.5	4.5	0.6	2.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.3	0.6	-0.5
Townsend deprivation index at recruitment	0.2	0.3	0.6	-0.3	-0.8
Current tobacco smoking	0.2	0.3	0.5	-0.7	-0.4
Medication: Levothyroxine sodium	0.2	0.4	0.7	-0.3	0.9
Impedance of leg (left)	0.2	0.9	1.1	-1.1	0.8
Had other major operations	0.2	0.2	0.5	-0.7	0.2
Diabetes (self-reported)	0.2	0.2	0.3	-0.5	0.5
Pulse rate	0.2	0.4	0.7	-0.8	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	-0.6	0.4
Impedance of arm (left)	0.2	1.1	1.9	-1.4	0.6
Peak expiratory flow (PEF)	0.2	0.4	0.8	0.1	-0.9
Neck or shoulder pain in last month	0.2	0.2	0.3	-0.4	-0.5
Mood swings	0.2	0.4	0.6	-0.8	-0.5
Diabetes diagnosed by doctor	0.2	0.2	0.5	-0.7	-0.0
Qualifications: nursing, teaching	0.2	0.3	0.4	0.4	0.7
Average weekly champagne plus white wine intake	0.2	0.3	0.3	-0.6	0.5
Ever smoked	0.2	0.4	0.7	-0.4	-0.8
Depression (Nagel 2018)	0.1	0.1	0.2	-0.1	0.4
Neuroticism (Nagel 2018)	0.1	0.3	0.5	-0.7	-0.4
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.2	-0.4
Reaction Time	0.1	0.1	0.2	0.2	-0.4
Coronary Artery Disease (CAD)	0.1	0.1	0.2	0.5	-0.2
Fasting Glucose	0.1	0.1	0.1	-0.4	-0.3
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	-0.6	-0.3
Relative age of first facial hair	0.1	0.2	0.5	-0.1	0.7
Vitamin and mineral supplements	0.1	0.1	0.2	-0.0	0.5
Alcohol usually taken with meals	0.1	0.1	0.2	-0.5	-0.3
Fluid intelligence score	0.1	0.2	0.3	0.2	0.6
Impedance of arm (right)	0.1	0.5	0.8	-0.9	0.5
Asthma	0.1	0.2	0.3	-0.6	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.3	0.6	0.1
Birth weight of first child	0.1	0.1	0.3	-0.1	-0.5
Pulse wave reflection index	0.1	0.1	0.1	0.4	-0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	-0.1	0.4
Loud music exposure frequency	0.1	0.2	0.3	0.1	-0.5
Medication: Amlodipine	0.1	0.2	0.3	-0.5	0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	-0.3	0.4
Forced vital capacity (FVC), Best measure	0.1	0.2	0.4	0.6	-0.3
Comparative body size at age 10	0.1	0.2	0.3	0.5	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.1	-0.4
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	-0.1	-0.6
Shortness of breath walking on level ground	0.1	0.1	0.1	-0.2	0.4
Medication: Omeprazole	0.1	0.1	0.2	-0.4	0.1
Pulse rate, automated reading	0.1	0.3	0.5	-0.7	-0.3
Number of full sisters	0.1	0.1	0.2	-0.5	-0.2
Knee pain experienced in last month	0.1	0.1	0.2	-0.5	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.4	-0.2	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.4	-0.4
Commuting to job workplace: Walk	0.1	0.1	0.1	0.0	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.3	0.6	-0.1
Asthma (self-reported)	0.1	0.2	0.3	-0.5	-0.2
Miserableness	0.1	0.1	0.2	-0.4	-0.0
Financial situation satisfaction	0.1	0.2	0.3	-0.0	-0.6
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.0	0.5
Medication: Blood pressure	0.1	0.3	0.5	-0.7	0.2
Medication: Bendroflumethiazide	0.1	0.1	0.2	-0.4	0.2
Medication: Atorvastatin	0.1	0.1	0.1	-0.3	0.3
Alcohol drinker status: Never	0.1	0.1	0.2	-0.1	0.5
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.5	-0.2
Heart disease (siblings)	0.1	0.1	0.2	-0.4	-0.1
Bipolar Disorder or Schizophrenia	0.0	0.1	0.1	0.3	0.2
Schizophrenia (2018)	0.0	0.1	0.1	-0.2	-0.3
Breast Cancer	0.0	0.1	0.1	-0.3	0.3
Lupus	0.0	0.0	0.1	0.2	0.1
Rheumatoid Arthritis	0.0	0.0	0.1	-0.2	-0.2
Hair Pigment	0.0	0.3	0.6	-0.8	0.1
Medication: Co-codamol	0.0	0.0	0.1	0.3	0.2
Medication: Metformin	0.0	0.0	0.0	0.2	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.1	0.1	-0.2
Qualifications: CSEs or equivalent	0.0	0.0	0.1	0.2	-0.1
Serious illness, injury or assault to yourself	0.0	0.0	0.0	0.1	-0.2
Sitting height	0.0	0.1	0.1	0.3	0.4
Forced vital capacity (FVC)	0.0	0.1	0.1	0.3	-0.2
Forced expiratory volume in 1-second (FEV1)	0.0	0.0	0.0	-0.2	0.1
Happiness	0.0	0.0	0.1	0.1	0.3
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	0.2	0.2
High blood pressure (siblings)	0.0	0.0	0.0	0.0	0.0
Number of children fathered	0.0	0.0	0.1	-0.0	0.3
Alcohol intake frequency.	0.0	0.1	0.2	-0.2	-0.4
Suffer from ‘nerves’	0.0	0.1	0.1	-0.3	-0.2
Had major operations	0.0	0.1	0.1	-0.1	0.3
Leg pain on walking	0.0	0.0	0.0	0.0	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.0	-0.1	-0.0
Supplements: Vitamin C	0.0	0.0	0.0	-0.1	-0.0
Average weekly red wine intake	0.0	0.1	0.1	-0.2	-0.3
Friendships satisfaction	0.0	0.0	0.0	-0.2	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.1	0.1	-0.3
Back pain experienced in last month	0.0	0.0	0.0	0.1	-0.0
Tinnitus: Yes, now most or all of the time	0.0	0.1	0.1	0.2	0.3

Hub : Genes

IPO7

Models

Trait associations