Hub : Genes

KLF7

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Testis 0.145 0.053 1.5e-03 0.083 NA 0.112 NA 0.150 1.6e-04 NA 1.2e-05 NA 3.4e-07
2 GTEx Thyroid 0.180 0.048 1.8e-05 0.150 NA 0.102 NA 0.131 1.5e-11 NA 3.4e-08 NA 3.2e-10
3 TCGA Testicular Germ Cell Tumors 0.192 0.091 4.5e-03 0.011 0.024 0.047 NA 0.027 1.2e-01 0.0470 9.3e-03 NA 3.8e-02
4 TCGA Thyroid Carcinoma 0.049 0.023 4.6e-03 0.025 0.022 0.023 NA 0.020 1.5e-03 0.0031 2.3e-03 NA 4.0e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.8 1.2 3.5 -1.0 -0.2 -1.9 -0.6
Bipolar Disorder or Schizophrenia 0.9 2.2 5.2 -1.8 0.6 -2.3 -0.2
Depressed Affect (Nagel 2018) 1.2 2.5 5.3 -2.3 1.9 -0.3 0.9
Depression (Nagel 2018) 0.9 1.3 4.1 -2.0 -0.5 0.6 -0.8
Intelligence (Savage-Jansen 2018) 0.7 2.1 4.0 -2.0 0.8 0.5 1.8
Neuroticism (Nagel 2018) 1.3 3.1 5.4 -2.3 1.0 2.3 0.8
Schizophrenia (2018) 0.6 1.3 2.2 -1.5 1.0 -1.4 0.2
Schizophrenia vs Biploar Disorder 0.7 1.0 2.7 -1.6 -0.0 -1.1 0.1
Worry (Nagel 2018) 1.0 2.1 7.6 -0.9 0.1 2.8 0.1
Alzheimer’s Disease (in mother) 0.3 0.3 0.7 0.2 -0.8 0.7 -0.1
Alzheimer’s Disease (in father) 1.0 1.0 3.2 -0.1 -0.8 -0.5 -1.8
Alzheimer’s Disease (including proxy) 0.1 0.2 0.6 0.1 -0.4 -0.1 -0.8
Crohns Disease (2017) 0.4 0.8 2.6 -1.6 -0.2 -0.4 -0.7
Irritable Bowel Disease (IBD) 0.2 0.4 1.2 -0.4 0.1 -1.1 -0.6
Ulcerative Colitis (UC) 0.3 0.6 1.5 0.5 0.8 -1.2 0.3
Major Depression (MDD) 4.0 4.9 19.1 -4.4 0.4 -0.3 -0.4
Reaction Time 0.9 1.7 6.6 -2.6 0.4 0.4 0.3
Verbal and Numeric Reasoning (VNR) 0.5 1.2 2.6 -1.3 0.3 0.6 1.6
Breast Cancer 0.4 1.1 3.1 -1.8 -0.1 1.0 -0.0
Ovarian Cancer 0.8 1.1 3.3 -1.8 0.6 -0.3 0.8
Prostate Cancer 1.2 1.7 2.7 1.6 -1.5 -1.2 -0.6
Age at First Birth 2.0 2.9 6.7 0.2 1.8 1.2 2.6
Bipolar Disorder (2011) 0.8 0.7 1.3 -0.6 -1.1 -0.4 -1.1
Body Mass Index (BMI) (2010) 1.6 2.3 8.3 -0.0 -0.1 -2.9 -0.9
Coronary Artery Disease (CAD) 1.2 1.4 5.0 0.2 -0.4 -2.2 -0.6
Crohns Disease (2012) 0.4 0.7 2.0 -1.4 0.8 -0.3 -0.2
Mean Putamen Volume 0.2 0.2 0.4 -0.5 0.6 -0.1 0.3
Fasting Glucose 1.0 1.2 3.4 -1.8 -0.0 0.1 -1.2
HbA1C 0.9 1.0 3.7 -1.9 -0.1 0.2 -0.4
HDL Cholesterol 0.1 0.1 0.2 -0.0 0.4 0.1 0.4
LDL Cholesterol 0.3 0.5 1.1 -0.7 0.6 1.1 0.0
Lupus 2.7 4.0 7.7 2.8 -0.9 -2.7 -0.5
Neuroticism (2016) 3.4 4.9 9.0 -3.0 1.0 2.8 1.2
Primary Biliary Cirrhosis 1.3 1.9 4.1 -0.2 2.0 -0.5 1.8
Rheumatoid Arthritis 0.6 0.9 2.0 1.4 0.7 -1.1 0.0
Schizophrenia (2014) 0.8 1.8 4.9 -1.2 0.4 -2.2 -0.8
Triglycerides 0.1 0.1 0.4 -0.1 0.4 0.6 -0.1
Type 2 Diabetes (T2D) (2012) 0.4 0.5 1.8 -0.4 0.1 -1.3 -0.2
Ulcerative Colitis 0.3 0.5 1.5 -0.4 0.6 -1.2 0.2
Blood Eosinophil Count 1.3 10.2 22.9 -4.1 0.4 4.8 0.9
Blood Platelet Count 1.0 11.4 18.1 -4.3 -1.5 -3.7 -3.4
Blood Red Count 2.3 22.7 48.3 1.5 6.9 -0.4 6.3
Blood White Count 0.3 2.5 9.9 -3.1 0.5 -0.2 0.2
Heel T-Score 0.6 4.5 11.5 -0.3 1.7 -3.4 1.9
BMI 2.2 12.7 39.4 0.8 -1.4 -6.3 -3.0
Height 0.3 4.9 10.2 3.2 -1.5 -1.6 -2.1
Waist Hip Ratio (WHR) 0.7 3.2 11.1 -1.0 0.6 3.3 0.6
Systolic Blood Pressure 0.7 3.6 12.2 -1.1 -0.9 -3.5 0.2
Smoking Status 2.1 5.0 12.3 -2.3 0.9 3.5 1.3
Allergy or Eczema 0.8 2.1 7.7 -2.8 -0.3 -0.1 -0.8
Cardiovascular Disease 2.1 7.0 10.9 -3.3 2.0 -3.0 1.9
Hypothyroidism (self reported) 1.3 3.0 4.2 -1.3 2.0 2.0 1.4
Respiratory disease 1.1 2.5 3.8 -1.6 1.9 1.5 1.2
Type 2 Diabetes (T2D) (2018) 1.0 1.8 5.5 -2.3 -0.5 -1.2 -0.5
Lung FEV1/FVC ratio 0.5 2.6 4.4 -1.1 -1.8 -1.1 -2.1
Lung FVC 0.2 0.8 1.8 1.1 -0.3 -1.3 -0.5
Neuroticism 1.1 2.7 5.4 -1.6 1.2 2.3 1.2
Chronotype (morning person) 3.2 7.5 14.5 -0.6 -3.1 -2.4 -3.8
Hair Pigment 0.4 10.3 24.1 0.5 4.9 0.2 4.1
Tanning 0.0 0.4 1.0 0.6 1.0 0.1 0.4
Hand grip strength (left) 2.2 5.8 11.8 3.4 -2.6 -0.4 -2.1
Number of treatments/medications taken 2.4 4.4 11.6 -3.4 0.9 1.5 1.8
Average weekly spirits intake 0.3 0.4 1.3 -0.0 -0.4 1.1 -0.5
Sensitivity / hurt feelings 1.3 2.3 6.9 -1.4 0.5 2.6 0.3
Frequency of depressed mood in last 2 weeks 1.2 1.7 6.2 -2.5 0.4 0.5 -0.0
Hearing difficulty/problems: Yes 3.0 4.6 9.0 -3.0 1.6 1.7 2.0
Relative age of first facial hair 1.3 2.7 7.0 2.7 0.7 0.3 1.8
Other serious medical condition/disability diagnosed by doctor 1.8 2.3 5.4 -1.7 2.3 0.0 0.8
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.4 -0.6 0.3 -0.6 0.1
Ever had hysterectomy (womb removed) 2.4 2.7 6.0 0.6 -1.6 -1.4 -2.4
Systolic blood pressure, automated reading 1.4 4.1 12.9 -0.7 -1.3 -3.6 -1.2
Eye problems/disorders: Diabetes related eye disease 1.3 1.4 4.2 -2.0 -0.5 -0.0 -1.1
Angina 2.3 3.0 11.2 -3.3 0.7 -0.4 0.3
Medication for hormone replacement therapy 0.2 0.3 0.8 -0.9 -0.0 -0.2 -0.4
Vitamin and mineral supplements 1.4 1.9 5.4 -2.3 -0.0 0.9 -1.3
Supplements: Zinc 2.1 2.3 8.5 2.9 -0.4 0.1 0.7
Medication: Co-codamol 2.4 2.8 9.6 -3.1 -0.2 1.3 0.0
Medication: Metformin 1.0 1.4 3.4 0.2 1.0 1.1 1.8
Diabetes (father) 0.3 0.4 0.9 -1.0 -0.2 -0.8 -0.1
Diabetes (mother) 0.5 0.6 1.5 0.0 0.1 1.2 1.0
Severe depression (siblings) 1.8 2.0 4.7 -2.2 1.2 0.5 1.3
Pack years adult smoking proportion 0.6 0.9 2.1 -1.4 0.6 0.3 1.1
Impedance of leg (right) 1.2 5.9 14.9 -3.9 0.2 2.9 0.4
Leg fat-free mass (left) 1.4 7.5 13.8 3.7 -0.7 -3.7 -1.4
Trunk fat percentage 0.6 2.6 3.9 -1.3 -1.0 -2.0 -2.0
Hand grip strength (right) 1.8 4.9 10.0 3.2 -2.2 -1.2 -1.9
Townsend deprivation index at recruitment 2.9 4.0 12.2 -3.5 -0.6 -1.6 -1.0
Current tobacco smoking 3.3 5.4 13.7 -3.7 0.9 2.6 0.8
Average weekly fortified wine intake 0.5 0.6 1.6 -1.3 0.1 -0.7 -0.5
Maternal smoking around birth 1.7 2.5 8.3 -2.9 -0.0 1.2 -0.7
Fed-up feelings 1.1 2.1 4.0 -2.0 1.2 -0.7 1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.5 4.3 -2.1 -1.0 0.0 -0.9
Relative age voice broke 2.2 3.3 12.5 3.5 -0.1 0.5 0.7
Taking other prescription medications 2.2 3.4 9.1 -3.0 0.8 1.8 0.7
Age when periods started (menarche) 0.7 1.8 2.1 -1.3 1.3 -1.5 1.2
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 2.3 1.3 -0.6 -1.5 -1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.7 2.1 1.4 1.2 -1.4 1.2
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.7 0.4 0.8 0.5 0.2
Qualifications: CSEs or equivalent 0.6 0.7 2.0 1.4 -0.0 1.0 0.0
Serious illness, injury or assault to yourself 1.0 1.2 3.7 -1.9 0.9 0.4 0.4
High blood pressure 1.6 4.5 8.4 -2.9 1.6 -1.8 2.0
Hayfever, allergic rhinitis or eczema 0.5 1.0 2.9 -1.7 -0.8 -0.0 -0.7
Multivitamins +/- minerals 1.3 1.7 2.9 1.7 0.4 -1.4 1.3
Stomach or abdominal pain in last month 1.4 1.7 3.3 -1.8 1.4 1.0 0.9
Supplements: Glucosamine 1.6 2.0 7.6 2.8 -0.7 0.2 -0.3
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.7 -0.5 -0.9 1.3 0.1
Medication: Atenolol 2.1 2.6 9.4 -3.1 0.6 0.2 0.6
Medication: Levothyroxine sodium 0.9 1.5 2.7 -1.6 0.8 1.6 0.4
Sitting height 0.3 2.4 9.4 3.1 0.1 -0.1 0.1
Chronic bronchitis/emphysema (father) 0.3 0.4 1.1 -0.5 0.4 0.4 1.0
High blood pressure (mother) 1.1 1.5 2.7 0.4 1.3 -1.6 1.1
Body mass index (BMI) 1.1 4.7 16.5 0.2 -0.3 -4.1 -1.5
Impedance of leg (left) 1.2 5.7 12.2 -3.1 0.5 3.5 0.7
Leg predicted mass (left) 1.4 7.7 14.7 3.7 -0.7 -3.8 -1.4
Trunk fat mass 0.8 3.5 7.7 -0.2 -1.0 -2.8 -2.3
Waist circumference 0.7 2.6 9.2 -0.5 0.1 -3.0 -0.9
Number of incorrect matches in round 0.2 0.4 0.8 0.1 -0.0 0.9 -0.8
Past tobacco smoking 1.8 3.3 10.7 1.4 -0.3 -3.3 -0.8
Alcohol usually taken with meals 3.1 5.0 16.8 1.4 0.1 -4.1 -1.0
Nervous feelings 2.6 4.9 7.7 -2.4 1.4 2.8 2.1
Frequency of tenseness / restlessness in last 2 weeks 1.9 3.0 9.3 -3.0 -0.3 0.6 -1.5
Hearing difficulty/problems with background noise 2.7 4.4 11.2 -3.4 1.4 1.6 1.3
Hair/balding pattern: Pattern 2 0.5 0.7 1.5 1.2 -0.3 -0.0 -1.1
Had menopause 0.4 0.5 1.0 -0.6 -1.0 0.2 -0.8
Had other major operations 0.3 0.4 0.6 0.7 0.8 -0.1 0.5
Forced vital capacity (FVC) 0.7 2.9 11.0 3.3 -0.2 -0.6 -0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 2.4 0.7 1.6 -1.5 1.2
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.8 -1.3 -0.2 0.0 -0.5
Qualifications: None of the above 3.0 6.5 11.9 -1.9 -3.5 -0.1 -3.2
Financial difficulties in last 2 years 3.1 4.1 9.1 -3.0 1.7 1.8 1.2
Mouth/teeth dental problems 1.9 2.9 5.8 2.0 1.4 0.3 2.4
Heart attack 1.5 1.9 4.8 -2.2 -0.5 -1.0 -1.3
Allergy 0.7 1.6 5.6 2.4 -0.6 -0.4 -0.5
Pain all over the body in last month 0.7 0.8 2.0 -1.4 -0.2 -0.5 -0.9
Diabetes (self-reported) 1.2 1.8 6.7 -2.6 0.2 0.6 0.5
Hayfever/allergic rhinitis (self-reported) 1.1 1.5 2.1 -0.6 1.3 -1.5 1.3
Medication: Ramipril 0.8 1.0 1.7 -1.3 -1.1 -0.5 -0.9
Medication: Simvastatin 0.7 1.1 2.4 -1.6 0.0 -1.1 0.9
Fluid intelligence score 0.5 1.1 2.0 -0.6 0.2 1.4 1.4
Illnesses of siblings 2.1 3.0 8.7 3.0 -0.8 1.6 0.1
Neuroticism score 0.6 1.2 1.6 -1.0 0.8 1.3 1.2
Weight 1.2 5.9 16.7 1.8 -0.7 -4.1 -1.8
Impedance of arm (right) 0.8 3.5 9.4 -2.1 0.0 3.1 0.4
Arm fat percentage (right) 0.9 3.5 8.3 -1.1 -0.7 -2.9 -2.0
Trunk fat-free mass 1.1 6.5 13.6 3.7 -0.3 -3.3 -1.3
Hip circumference 1.5 6.3 24.4 0.6 0.3 -4.9 -0.7
Time employed in main current job 0.1 0.2 0.4 -0.7 0.1 -0.0 0.5
Alcohol intake versus 10 years previously 1.0 1.5 3.9 1.2 -2.0 -0.1 -0.9
Father’s age at death 0.6 0.8 1.8 0.9 0.8 1.3 0.3
Worrier / anxious feelings 0.6 1.1 3.9 -0.6 -0.0 2.0 -0.5
Frequency of tiredness / lethargy in last 2 weeks 2.8 4.5 17.1 -4.1 1.0 0.0 0.3
Falls in the last year 1.4 1.9 4.8 -2.2 1.3 -0.7 0.8
Hair/balding pattern: Pattern 3 0.7 1.1 2.0 0.0 0.9 1.3 1.4
Number of live births 0.4 0.5 1.0 -0.2 -0.9 -1.0 -0.4
Forced expiratory volume in 1-second (FEV1) 0.7 2.4 6.5 2.5 -0.6 -1.5 -0.7
Pulse rate 1.3 2.3 5.5 0.8 1.1 2.3 1.3
Happiness 0.9 1.1 1.6 0.2 1.2 1.1 1.3
Noisy workplace 1.6 2.0 4.7 -1.1 -1.5 0.2 -2.2
Qualifications: A levels/AS levels or equivalent 1.2 2.7 5.1 -0.2 2.3 0.7 2.3
Serious illness, injury or assault of a close relative in last 2 years 2.2 2.5 3.8 1.9 1.6 -1.0 1.7
Mouth/teeth dental problems: Dentures 0.8 1.3 1.9 -1.3 -1.2 -0.3 -1.4
Asthma 1.6 3.1 5.5 -2.1 2.4 0.6 1.4
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 1.5 -0.2 0.2 -1.2 -0.4
Medication: Cholesterol lowering 1.1 1.7 5.1 -2.2 -1.1 -0.3 -0.5
Depression (self-reported) 1.0 1.2 3.3 -1.0 -0.5 1.8 0.4
Medication: Lansoprazole 2.2 2.5 3.2 -1.8 1.6 1.2 1.6
Prospective memory result 1.4 1.7 5.7 0.1 -0.5 2.4 -0.9
Lung cancer (father) 1.2 1.4 3.4 0.9 -1.1 0.3 -1.8
Illnesses of mother 0.0 0.0 0.1 -0.0 -0.1 -0.1 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.3 6.9 2.6 0.1 -1.5 -0.3
Pulse wave Arterial Stiffness index 1.3 1.5 2.9 -0.6 -1.7 1.1 -1.3
Impedance of arm (left) 1.0 4.7 11.8 -2.7 -0.0 3.4 0.4
Arm fat mass (right) 1.0 4.3 11.8 0.6 -0.8 -3.4 -2.1
Trunk predicted mass 1.1 6.2 13.0 3.6 -0.2 -3.2 -1.3
Standing height 0.5 4.7 15.7 4.0 -1.2 -0.6 -1.1
Length of working week for main job 0.4 0.4 0.8 0.9 0.1 -0.8 -0.4
Exposure to tobacco smoke at home 0.9 1.0 2.1 0.2 -1.2 1.4 -0.5
Breastfed as a baby 3.1 3.8 6.8 2.6 1.2 0.5 2.6
Tense / ‘highly strung’ 0.9 1.4 5.6 0.0 0.1 2.4 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 2.0 3.0 5.4 -2.3 1.1 2.1 1.1
Hair/balding pattern: Pattern 4 1.9 4.5 8.5 -2.0 2.3 -0.3 2.9
Birth weight of first child 0.6 1.1 3.0 1.2 -0.3 1.7 0.0
Peak expiratory flow (PEF) 0.4 0.9 1.8 -0.2 -1.0 -1.3 -0.9
Pulse wave reflection index 0.1 0.2 0.3 -0.1 -0.2 -0.6 0.5
Ever highly irritable/argumentative for 2 days 2.0 2.4 6.3 -2.5 1.5 0.9 0.4
Loud music exposure frequency 1.0 1.0 2.6 0.7 1.6 -0.6 0.8
Qualifications: O levels/GCSEs or equivalent 2.7 4.2 8.2 1.1 2.9 0.5 2.7
Mouth/teeth dental problems: Bleeding gums 1.6 2.0 4.2 -0.7 -0.4 -1.8 -2.0
Blood clot in the leg (DVT) 0.9 1.2 2.9 -1.7 1.2 0.6 0.3
Medication: Paracetamol 2.2 3.7 7.7 -2.8 2.2 -0.5 1.4
Headache pain in last month 1.2 2.1 4.0 -1.5 0.8 -2.0 1.3
Medication for cholesterol, blood pressure or diabetes 1.4 2.3 8.4 2.9 0.4 0.6 -0.3
Glaucoma (self-reported) 1.7 2.0 4.7 0.3 -1.6 -2.2 -0.7
Gout (self-reported) 0.9 1.2 2.6 -0.1 1.2 0.8 1.6
Hypothyroidism/myxoedema (self-reported) 1.4 2.7 4.8 -1.3 1.6 2.2 1.3
Medication: Amlodipine 1.3 1.8 3.1 -0.8 1.5 -1.1 1.8
Medication: Ventolin 100micrograms inhaler 0.5 0.7 1.9 -1.4 0.6 0.5 0.6
Birth weight 0.4 0.8 1.9 1.4 -0.8 0.4 -0.8
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.0 -1.0 0.2 0.1 -0.7
High blood pressure (siblings) 1.4 2.0 7.7 -2.8 0.2 -0.6 -0.2
Forced vital capacity (FVC), Best measure 0.8 3.0 10.4 3.2 0.4 -1.1 -0.1
Body fat percentage 0.8 3.2 5.6 -1.7 -0.7 -2.4 -2.0
Leg fat percentage (right) 1.0 3.7 8.0 -2.0 -0.3 -2.8 -1.7
Arm fat-free mass (right) 1.3 6.6 12.0 3.3 -0.7 -3.5 -1.7
Exposure to tobacco smoke outside home 0.9 1.2 2.5 -0.9 -0.2 -1.6 -1.3
Comparative body size at age 10 1.2 3.2 6.9 -1.7 -1.6 -0.6 -2.6
Number of full brothers 1.8 2.3 7.9 -0.9 -0.2 -2.8 -0.7
Worry too long after embarrassment 1.7 2.9 9.9 -0.9 -0.9 3.1 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.8 2.8 -1.7 -0.4 -0.5 -0.5
Wheeze or whistling in the chest in last year 0.5 1.0 1.8 -1.2 1.4 0.6 0.4
Number of children fathered 0.6 0.6 1.0 -1.0 -0.2 -1.0 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 2.9 -0.7 -1.7 -0.8 -0.4
Age at first live birth 0.9 1.5 2.8 1.7 1.4 -0.0 1.1
Pulse wave peak to peak time 1.1 1.3 2.0 0.9 1.4 -1.2 1.0
Health satisfaction 1.8 2.4 7.0 -2.7 0.9 0.7 1.1
Shortness of breath walking on level ground 2.2 2.7 6.7 -2.6 0.9 -1.8 0.3
Qualifications: College or University degree 0.3 0.9 2.5 0.8 -0.7 -1.6 -0.3
Eye problems/disorders: None of the above 0.3 0.3 1.2 1.1 -0.2 0.2 -0.4
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.9 -1.4 0.1 0.2 0.6
Emphysema/chronic bronchitis 2.0 2.3 6.2 -1.1 2.5 0.1 1.3
Medication for pain relief, constipation, heartburn 4.4 7.5 27.2 5.2 -1.6 0.2 -0.5
Neck or shoulder pain in last month 1.9 2.7 9.4 -3.1 -0.6 0.7 -0.9
Medication: Blood pressure 1.3 2.3 7.7 -2.8 0.0 -1.0 0.8
Angina (self-reported) 1.8 2.4 9.3 -3.0 0.5 -0.3 0.1
Migraine (self-reported) 0.6 0.7 1.6 -1.3 0.9 0.4 0.6
Medication: Ibuprofen 0.2 0.3 0.7 -0.5 0.8 -0.5 0.3
Medication: Allopurinol 0.9 1.2 3.3 0.8 0.8 0.5 1.8
Medication: Omeprazole 0.8 1.0 1.8 -1.3 1.0 0.8 0.6
Medication: Seretide 50 evohaler 0.3 0.4 1.0 -1.0 0.3 -0.7 -0.0
Mean time to correctly identify matches 2.9 5.6 20.4 -4.5 -1.1 -0.2 -0.8
Heart disease (mother) 0.3 0.4 0.5 0.7 0.6 -0.6 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 0.4 -0.2 -0.6 0.2 0.4
Whole body fat mass 0.9 3.9 10.3 -0.2 -0.8 -3.2 -2.1
Leg fat mass (right) 1.1 4.2 12.9 -0.2 -0.6 -3.6 -1.9
Arm predicted mass (right) 1.3 6.7 12.5 3.5 -0.3 -3.5 -1.4
Pulse rate, automated reading 1.2 3.8 7.8 0.5 1.7 2.1 2.8
Alcohol intake frequency. 1.6 3.8 7.1 -2.0 -2.7 -0.2 -2.0
Comparative height size at age 10 0.3 1.6 6.0 2.4 0.0 -0.5 -0.4
Number of full sisters 1.0 1.2 4.7 -2.2 0.4 -0.1 0.4
Suffer from ‘nerves’ 0.4 0.7 1.5 -1.2 0.4 0.1 1.0
Overall health rating 4.2 9.0 26.0 -5.1 2.7 0.4 1.6
Chest pain or discomfort 2.8 4.0 10.3 -3.2 1.3 1.7 1.1
Had major operations 0.5 0.6 1.0 -1.0 -0.4 0.3 -1.0
Age at last live birth 0.7 1.1 2.5 0.8 0.7 0.8 1.6
Family relationship satisfaction 0.6 0.8 1.5 -1.0 0.6 1.2 0.5
Leg pain on walking 1.3 1.6 5.3 -2.3 0.4 0.7 0.7
Qualifications: NVQ or HND or HNC or equivalent 1.6 1.9 6.1 0.8 0.1 -2.5 -1.1
Commuting to job workplace: Car/motor vehicle 1.5 1.7 3.2 0.1 -1.8 -1.2 -1.4
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 2.7 0.2 -1.6 -0.7 -1.2
Medication: Aspirin 3.9 5.1 19.9 -4.5 0.6 0.3 -0.2
Supplements: Vitamin C 1.0 1.1 2.6 1.6 -1.2 -0.1 -0.7
Knee pain experienced in last month 2.9 4.5 12.6 -3.5 -0.9 -1.2 -1.8
Hypertension (Self-reported) 1.5 4.1 9.3 -3.0 1.0 -1.7 1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.1 2.4 6.4 -2.5 1.1 0.9 1.2
Illnesses of father: Heart disease 0.3 0.4 1.2 0.4 -0.6 -1.1 0.1
Illnesses of siblings: Diabetes 1.4 1.7 4.0 -0.2 -0.8 -2.0 -1.4
Smoking status: Previous 1.0 1.5 5.7 -0.0 0.0 2.4 0.5
Forced expiratory volume in 1-second (FEV1), predicted 1.4 3.0 6.9 2.6 2.0 -0.1 1.1
Whole body fat-free mass 1.3 7.5 15.1 3.9 -0.4 -3.6 -1.4
Leg fat-free mass (right) 1.5 8.1 19.1 4.4 -0.5 -3.4 -1.0
Arm fat percentage (left) 1.0 3.8 8.4 -1.2 -0.8 -2.9 -2.2
Average weekly red wine intake 0.2 0.3 0.6 0.8 -0.5 0.7 0.0
Handedness (chirality/laterality): Left-handed 1.8 2.2 5.0 -0.3 -1.9 -0.4 -2.2
Mood swings 0.7 1.3 2.3 -1.5 1.0 0.8 1.1
Loneliness, isolation 1.7 2.3 4.7 -2.2 1.1 -1.8 -0.0
Long-standing illness, disability or infirmity 2.7 4.1 15.0 -3.9 1.1 0.1 0.3
Ever had bowel cancer screening 2.0 2.3 4.5 -1.2 -1.7 2.1 -0.5
Diabetes diagnosed by doctor 0.3 0.6 1.8 -1.4 0.1 -0.1 0.6
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 2.2 -0.4 0.8 1.5 1.2
Friendships satisfaction 0.3 0.3 0.6 -0.5 0.8 -0.2 0.6
Qualifications: nursing, teaching 0.7 1.2 3.0 0.6 1.7 -0.7 0.9
Commuting to job workplace: Walk 0.5 0.6 1.2 0.5 0.9 1.1 0.3
Eye problems/disorders: Cataract 1.2 1.4 3.2 0.3 1.3 -0.6 1.8
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 2.1 -1.4 -1.1 0.7 -0.8
Medication for cholesterol 0.9 1.4 3.8 2.0 -0.3 1.1 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.3 -1.1 0.3 -0.3 0.4
Back pain experienced in last month 1.9 2.7 10.4 -3.2 0.0 -0.3 -0.6
Mineral and other dietary supplements 3.3 4.4 12.9 -3.6 1.3 -1.4 -1.0
Breast cancer (self-reported) 2.1 2.4 5.6 1.1 -1.4 -2.4 -1.0
Asthma (self-reported) 1.5 3.1 5.5 -2.0 2.4 0.7 1.5
Osteoporosis (self-reported) 2.2 2.7 3.8 0.8 -1.8 1.9 -1.8
Osteoarthritis (self-reported) 0.8 1.1 2.1 -1.4 -0.5 -0.6 -1.3
Medication: Aspirin 3.6 4.7 18.1 -4.3 0.5 0.3 -0.4
Medication: Gliclazide 0.8 0.9 2.4 1.6 0.4 0.3 0.9
Illnesses of father: None of the above (group 1) 0.3 0.4 0.9 0.6 0.9 0.3 -0.2
Smoking status: Current 2.7 4.4 10.5 -3.2 0.3 2.5 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.7 3.7 8.3 1.5 -0.7 -2.9 -1.9
Whole body water mass 1.3 7.4 15.4 3.9 -0.4 -3.5 -1.3
Leg predicted mass (right) 1.5 7.8 19.0 4.4 -0.4 -3.3 -1.0
Arm fat mass (left) 1.1 4.6 13.5 0.3 -0.8 -3.7 -2.0
Number of self-reported non-cancer illnesses 3.0 5.2 15.8 -4.0 1.2 1.3 1.4
Average weekly champagne plus white wine intake 1.8 2.5 4.9 -1.5 2.2 -1.3 1.0
Miserableness 2.4 4.2 7.8 -2.8 2.1 -1.2 1.7
Guilty feelings 0.3 0.4 0.8 0.8 0.6 0.2 0.9
Wears glasses or contact lenses 0.4 0.4 1.3 0.5 -0.3 -1.1 -0.4
Ever taken oral contraceptive pill 1.8 2.0 3.1 -0.7 1.8 1.3 1.7
Hearing aid user 2.1 2.3 5.4 -2.3 -0.1 -1.4 -1.4
Mother’s age at death 0.8 1.0 2.2 -1.2 -0.3 0.4 -1.5
Financial situation satisfaction 2.8 3.4 7.0 -0.8 2.7 0.1 2.5
Tinnitus: Yes, now most or all of the time 1.3 1.6 3.0 -0.0 -1.7 -0.6 -1.7
Commuting to job workplace: Public transport 3.2 3.8 11.2 -1.2 3.3 -0.0 1.6
Eye problems/disorders: Glaucoma 1.2 1.4 2.0 -1.4 -1.3 -1.2 -0.6
Medication: Blood pressure 0.9 1.8 3.7 -1.9 0.6 -1.5 0.8
Pain type(s) experienced in last month: Hip pain 1.6 2.0 4.1 -2.0 -0.2 1.8 0.6
Supplements: Fish oil (including cod liver oil) 3.7 4.8 15.5 3.9 -1.6 1.1 0.2
High cholesterol (Self-reported) 0.8 1.5 3.8 -1.9 0.4 -1.2 0.7
Medication: Bendroflumethiazide 0.8 1.3 2.1 -0.1 -1.4 -1.3 -1.2
Medication: Paracetamol 3.0 4.6 7.7 -2.7 2.8 -0.5 1.8
Medication: Lisinopril 2.7 3.4 7.4 -1.5 2.0 0.1 2.7
Medication: Atorvastatin 0.5 0.6 2.2 -1.5 -0.0 0.2 0.1
Illnesses of father: High blood pressure 1.6 2.0 6.8 -2.6 0.5 0.3 0.9
Alcohol drinker status: Never 1.2 1.5 3.5 -1.5 0.1 -1.9 0.1
Ever smoked 1.7 3.1 6.1 -1.8 1.0 2.5 1.4
Basal metabolic rate 1.3 7.5 14.6 3.6 -0.5 -3.8 -1.5
Leg fat percentage (left) 0.7 2.6 6.1 -1.3 -0.3 -2.5 -1.6
Arm fat-free mass (left) 1.5 7.5 14.2 3.6 -0.7 -3.8 -1.5
Number of operations (self-reported) 0.8 1.2 2.8 1.7 -0.3 1.4 -0.1
Average weekly beer plus cider intake 3.0 4.3 8.0 1.6 2.5 0.4 2.8
Irritability 1.6 2.7 5.2 1.2 0.5 2.3 2.0
Risk taking 0.8 1.2 2.7 -1.6 -0.1 -0.9 -1.1
Ever had prostate specific antigen (PSA) test 1.5 1.7 6.4 -2.5 -0.4 0.3 -0.2
Fractured/broken bones in last 5 years 1.2 1.5 5.2 -0.7 -0.1 2.3 0.6
Age started oral contraceptive pill 0.5 0.6 1.0 -0.2 -1.0 -1.0 -0.5
Diastolic blood pressure, automated reading 1.3 4.1 7.9 -1.5 2.8 -1.6 1.9
Ever depressed for a whole week 2.9 3.5 6.5 -2.3 -1.5 -0.1 -2.5
Unable to work because of sickness or disability 1.7 2.1 4.8 -2.2 1.4 -0.5 1.3
Commuting to job workplace: Cycle 2.2 2.7 5.5 0.9 1.8 -1.1 2.4
Myopia 0.9 1.2 1.9 1.1 1.4 -0.5 1.2
Vascular/heart problems diagnosed by doctor 1.9 5.1 13.3 3.6 -1.5 1.3 -1.8
Cholesterol lowering medication 0.8 1.2 1.9 -1.1 0.5 -1.2 1.4
Medication: Omeprazole (e.g. Zanprol) 1.4 1.6 3.3 -1.8 1.3 1.2 0.5
Pain experienced in last month 2.7 4.4 17.1 4.1 0.4 -0.2 0.7
Supplements: Calcium 0.4 0.4 1.3 0.4 -1.1 0.4 0.1
Basal cell carcinoma (self-reported) 0.7 0.8 2.9 -0.0 -0.3 -1.7 -0.6
Heart attack/myocardial infarction (self-reported) 1.2 1.5 4.0 -2.0 -0.4 -0.9 -1.1
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 2.7 -1.6 1.5 0.5 0.5
Heart disease (siblings) 0.6 0.8 1.6 -1.3 0.8 -1.0 0.2
Alcohol drinker status: Previous 1.5 1.7 4.6 -1.3 -0.6 2.1 -0.3
Pack years of smoking 0.4 0.6 1.9 -1.4 0.1 -0.2 0.6
Impedance of whole body 1.2 6.3 15.0 -3.1 0.4 3.9 0.6
Leg fat mass (left) 1.1 4.2 12.2 0.2 -0.7 -3.5 -2.0
Arm predicted mass (left) 1.4 7.3 13.8 3.7 -0.4 -3.7 -1.4