Hub : Traits :

Medication for pain relief, constipation, heartburn

275 significantly associated models · 41 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 149771890 151174772 1 1 2.7e-07 2.5e-07 1.0000 100 TARS2
2 1 155739430 157168420 1 1 3.6e-10 6.4e-12 0.0044 83 MEF2D
3 1 173103273 175689679 4 1 7.5e-08 1.1e-09 0.0044 78 RABGAP1L
4 1 242590540 244359621 2 1 4.5e-08 3.1e-08 1.0000 100 SDCCAG8
5 2 26624843 28503968 4 2 4.0e-08 2.0e-07 0.8840 100 CGREF1 NRBP1
6 2 207107801 208729540 2 1 1.8e-07 1.3e-08 0.0122 80 KLF7
7 6 25285943 26689223 1 1 1.2e-13 4.7e-11 0.0112 85 U91328.21
8 6 34065982 35751895 2 2 1.2e-08 8.9e-09 0.2700 96 ANKS1A UHRF1BP1
9 6 96275538 97756290 3 2 2.0e-08 5.9e-10 0.0465 90 FHL5 KIAA0776
10 12 56776586 58303535 4 2 2.1e-18 6.0e-18 1.0000 100 LRP1 TMEM194A
11 17 42774693 45796313 17 1 1.6e-10 2.5e-09 0.2220 96 LRRC37A4P

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Major Depression (MDD) 2.75 1 0 0.0 0.00 1.0e+00 KLF7
Reaction Time 1.80 1 0 0.0 0.00 1.0e+00 TARS2
Verbal and Numeric Reasoning (VNR) 1.80 1 1 3.0 0.00 1.0e+00 U91328.21
Breast Cancer 1.75 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Ovarian Cancer 2.67 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Coronary Artery Disease (CAD) 3.25 2 0 0.0 0.00 1.0e+00 ANKS1A UHRF1BP1
Fasting Glucose 3.74 1 1 3.0 0.00 1.0e+00 CGREF1
HDL Cholesterol 1.68 1 0 0.0 0.00 1.0e+00 UHRF1BP1
Lupus 1.92 1 0 0.0 0.00 1.0e+00 UHRF1BP1
Neuroticism 3.13 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Primary Biliary Cirrhosis 2.53 1 0 0.0 0.00 1.0e+00 LRP1
Schizophrenia 1.70 2 0 0.0 0.00 1.0e+00 NRBP1 SDCCAG8
Triglycerides 7.26 2 2 6.1 0.00 1.0e+00 CGREF1 NRBP1
Blood Eosinophil Count 1.93 5 3 9.1 -0.42 4.8e-01 ANKS1A KLF7 LRP1 LRRC37A4P TARS2
Blood Platelet Count 4.35 7 5 15.2 0.41 3.6e-01 CGREF1 KLF7 LRRC37A4P MEF2D NRBP1 TARS2 UHRF1BP1
Blood Red Count 2.88 3 2 6.1 0.00 1.0e+00 LRRC37A4P NRBP1 RABGAP1L
Blood White Count 2.18 6 3 9.1 0.68 1.4e-01 CGREF1 LRRC37A4P MEF2D NRBP1 TARS2 UHRF1BP1
Heel T-Score 0.74 2 1 3.0 0.00 1.0e+00 LRRC37A4P MEF2D
BMI 4.28 4 2 6.1 0.35 6.5e-01 ANKS1A LRP1 MEF2D UHRF1BP1
Height 1.21 7 7 21.2 -0.36 4.3e-01 ANKS1A CGREF1 LRP1 LRRC37A4P MEF2D NRBP1 UHRF1BP1
Waist Hip Ratio (WHR) 3.09 3 3 9.1 0.00 1.0e+00 LRRC37A4P MEF2D UHRF1BP1
Systolic Blood Pressure 3.03 7 3 9.1 0.70 7.8e-02 CGREF1 FHL5 KIAA0776 LRRC37A4P MEF2D NRBP1 SDCCAG8
Allergy or Eczema 1.65 1 0 0.0 0.00 1.0e+00 LRP1
Cardiovascular Disease 3.02 4 1 3.0 0.99 8.4e-03 ANKS1A CGREF1 SDCCAG8 UHRF1BP1
Hypothyroidism (self reported) 1.24 1 0 0.0 0.00 1.0e+00 UHRF1BP1
Respiratory disease 3.22 4 1 3.0 -0.22 7.8e-01 FHL5 LRP1 RABGAP1L TARS2
Lung FEV1/FVC ratio 3.52 5 1 3.0 -0.55 3.3e-01 LRP1 LRRC37A4P MEF2D TARS2 TMEM194A
Lung FVC 2.70 2 1 3.0 0.00 1.0e+00 LRRC37A4P MEF2D
Neuroticism 4.12 2 1 3.0 0.00 1.0e+00 LRRC37A4P RABGAP1L
Chronotype (morning person) 2.32 1 1 3.0 0.00 1.0e+00 TARS2
Hair Pigment 0.42 5 1 3.0 -0.02 9.7e-01 CGREF1 LRP1 LRRC37A4P NRBP1 TMEM194A
Hand grip strength (left) 2.56 2 1 3.0 0.00 1.0e+00 ANKS1A LRRC37A4P
Number of treatments/medications taken 7.87 8 1 3.0 -0.99 4.4e-06 ANKS1A CGREF1 LRP1 MEF2D NRBP1 RABGAP1L SDCCAG8 U91328.21
Sensitivity / hurt feelings 3.55 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Relative age of first facial hair 3.15 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Systolic blood pressure, automated reading 2.48 3 1 3.0 0.00 1.0e+00 FHL5 KIAA0776 LRRC37A4P
Vitamin and mineral supplements 4.01 1 1 3.0 0.00 1.0e+00 LRP1
Impedance of leg (right) 1.46 3 1 3.0 0.00 1.0e+00 KLF7 TARS2 UHRF1BP1
Leg fat-free mass (left) 2.23 2 1 3.0 0.00 1.0e+00 CGREF1 UHRF1BP1
Trunk fat percentage 3.63 2 2 6.1 0.00 1.0e+00 ANKS1A UHRF1BP1
Hand grip strength (right) 2.27 2 1 3.0 0.00 1.0e+00 LRP1 LRRC37A4P
Fed-up feelings 2.73 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Relative age voice broke 2.17 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Taking other prescription medications 3.18 1 0 0.0 0.00 1.0e+00 UHRF1BP1
High blood pressure 2.70 3 0 0.0 0.00 1.0e+00 CGREF1 FHL5 SDCCAG8
Hayfever, allergic rhinitis or eczema 1.34 1 0 0.0 0.00 1.0e+00 LRP1
Multivitamins +/- minerals 2.39 1 0 0.0 0.00 1.0e+00 LRP1
Supplements: Glucosamine 2.21 1 0 0.0 0.00 1.0e+00 TARS2
Medication: Levothyroxine sodium 2.82 2 1 3.0 0.00 1.0e+00 ANKS1A UHRF1BP1
Sitting height 2.04 4 2 6.1 0.29 7.1e-01 CGREF1 LRP1 LRRC37A4P UHRF1BP1
Body mass index (BMI) 3.55 2 2 6.1 0.00 1.0e+00 ANKS1A UHRF1BP1
Impedance of leg (left) 1.36 2 1 3.0 0.00 1.0e+00 TARS2 UHRF1BP1
Leg predicted mass (left) 2.23 2 1 3.0 0.00 1.0e+00 CGREF1 UHRF1BP1
Trunk fat mass 3.49 2 2 6.1 0.00 1.0e+00 ANKS1A UHRF1BP1
Waist circumference 2.71 2 2 6.1 0.00 1.0e+00 ANKS1A UHRF1BP1
Alcohol usually taken with meals 2.13 1 1 3.0 0.00 1.0e+00 RABGAP1L
Nervous feelings 2.49 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Frequency of tenseness / restlessness in last 2 weeks 2.65 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Hearing difficulty/problems with background noise 2.33 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Hair/balding pattern: Pattern 2 1.91 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Had menopause 2.27 1 0 0.0 0.00 1.0e+00 NRBP1
Forced vital capacity (FVC) 3.43 3 3 9.1 0.00 1.0e+00 ANKS1A LRRC37A4P U91328.21
Mouth/teeth dental problems 1.95 1 0 0.0 0.00 1.0e+00 SDCCAG8
Allergy 1.68 1 0 0.0 0.00 1.0e+00 LRP1
Hayfever/allergic rhinitis (self-reported) 2.40 1 0 0.0 0.00 1.0e+00 LRP1
Fluid intelligence score 1.84 1 0 0.0 0.00 1.0e+00 U91328.21
Neuroticism score 3.63 2 1 3.0 0.00 1.0e+00 LRRC37A4P RABGAP1L
Weight 3.00 2 1 3.0 0.00 1.0e+00 ANKS1A UHRF1BP1
Impedance of arm (right) 1.29 2 0 0.0 0.00 1.0e+00 CGREF1 UHRF1BP1
Arm fat percentage (right) 3.37 2 2 6.1 0.00 1.0e+00 ANKS1A UHRF1BP1
Trunk fat-free mass 1.72 4 2 6.1 -0.19 8.1e-01 CGREF1 LRP1 RABGAP1L UHRF1BP1
Hip circumference 3.58 2 1 3.0 0.00 1.0e+00 ANKS1A UHRF1BP1
Worrier / anxious feelings 1.71 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Frequency of tiredness / lethargy in last 2 weeks 2.46 1 0 0.0 0.00 1.0e+00 KLF7
Hair/balding pattern: Pattern 3 2.91 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Number of live births 1.77 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Forced expiratory volume in 1-second (FEV1) 3.68 3 2 6.1 0.00 1.0e+00 ANKS1A LRRC37A4P U91328.21
Qualifications: A levels/AS levels or equivalent 1.96 1 0 0.0 0.00 1.0e+00 SDCCAG8
Asthma 3.39 3 0 0.0 0.00 1.0e+00 LRP1 TARS2 U91328.21
Medication: Ibuprofen (e.g. Nurofen) 11.24 6 1 3.0 -0.98 4.7e-04 KIAA0776 LRP1 MEF2D TARS2 TMEM194A U91328.21
Medication: Cholesterol lowering 2.51 2 0 0.0 0.00 1.0e+00 CGREF1 MEF2D
Forced expiratory volume in 1-second (FEV1), Best measure 3.40 3 2 6.1 0.00 1.0e+00 ANKS1A LRRC37A4P U91328.21
Impedance of arm (left) 1.43 2 0 0.0 0.00 1.0e+00 CGREF1 UHRF1BP1
Arm fat mass (right) 3.41 2 2 6.1 0.00 1.0e+00 ANKS1A UHRF1BP1
Trunk predicted mass 1.72 4 2 6.1 -0.21 7.9e-01 CGREF1 LRP1 RABGAP1L UHRF1BP1
Standing height 1.16 6 2 6.1 -0.34 5.1e-01 ANKS1A CGREF1 KLF7 LRP1 LRRC37A4P U91328.21
Exposure to tobacco smoke at home 1.84 1 0 0.0 0.00 1.0e+00 UHRF1BP1
Tense / 'highly strung' 2.11 1 1 3.0 0.00 1.0e+00 RABGAP1L
Seen doctor (GP) for nerves, anxiety, tension or depression 1.81 1 0 0.0 0.00 1.0e+00 U91328.21
Hair/balding pattern: Pattern 4 4.65 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Peak expiratory flow (PEF) 2.75 3 1 3.0 0.00 1.0e+00 LRRC37A4P TARS2 U91328.21
Medication: Paracetamol 15.97 10 5 15.2 -0.99 1.5e-07 CGREF1 FHL5 KIAA0776 LRP1 LRRC37A4P MEF2D NRBP1 RABGAP1L SDCCAG8 U91328.21
Headache pain in last month 21.20 10 7 21.2 -0.94 4.2e-05 FHL5 KIAA0776 LRP1 LRRC37A4P MEF2D RABGAP1L SDCCAG8 TARS2 TMEM194A U91328.21
Gout (self-reported) 3.41 1 1 3.0 0.00 1.0e+00 CGREF1
Hypothyroidism/myxoedema (self-reported) 1.66 1 0 0.0 0.00 1.0e+00 UHRF1BP1
High blood pressure (siblings) 2.87 1 0 0.0 0.00 1.0e+00 CGREF1
Forced vital capacity (FVC), Best measure 3.09 3 2 6.1 0.00 1.0e+00 ANKS1A LRRC37A4P U91328.21
Body fat percentage 3.83 3 2 6.1 0.00 1.0e+00 ANKS1A LRP1 UHRF1BP1
Leg fat percentage (right) 4.27 4 2 6.1 -0.44 5.6e-01 ANKS1A LRP1 TARS2 UHRF1BP1
Arm fat-free mass (right) 1.82 2 1 3.0 0.00 1.0e+00 CGREF1 UHRF1BP1
Exposure to tobacco smoke outside home 2.78 2 0 0.0 0.00 1.0e+00 LRRC37A4P SDCCAG8
Comparative body size at age 10 2.38 3 1 3.0 0.00 1.0e+00 TARS2 U91328.21 UHRF1BP1
Qualifications: College or University degree 2.21 3 2 6.1 0.00 1.0e+00 LRRC37A4P RABGAP1L SDCCAG8
Emphysema/chronic bronchitis 2.41 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Migraine (self-reported) 12.78 4 3 9.1 -0.97 2.6e-02 FHL5 KIAA0776 LRP1 MEF2D
Medication: Ibuprofen 8.61 3 1 3.0 0.00 1.0e+00 LRP1 MEF2D TMEM194A
Medication: Allopurinol 2.19 1 0 0.0 0.00 1.0e+00 CGREF1
Medication: Omeprazole 3.55 2 0 0.0 0.00 1.0e+00 TARS2 UHRF1BP1
Mean time to correctly identify matches 1.63 1 0 0.0 0.00 1.0e+00 KLF7
Whole body fat mass 3.56 2 2 6.1 0.00 1.0e+00 ANKS1A UHRF1BP1
Leg fat mass (right) 4.08 2 2 6.1 0.00 1.0e+00 ANKS1A UHRF1BP1
Arm predicted mass (right) 1.87 2 1 3.0 0.00 1.0e+00 CGREF1 UHRF1BP1
Pulse rate, automated reading 2.38 3 2 6.1 0.00 1.0e+00 MEF2D RABGAP1L UHRF1BP1
Alcohol intake frequency. 4.01 3 1 3.0 0.00 1.0e+00 CGREF1 LRP1 LRRC37A4P
Comparative height size at age 10 1.41 3 1 3.0 0.00 1.0e+00 CGREF1 LRRC37A4P U91328.21
Overall health rating 3.88 4 1 3.0 -0.99 5.4e-03 KLF7 RABGAP1L SDCCAG8 UHRF1BP1
Medication: Aspirin 4.50 2 0 0.0 0.00 1.0e+00 KLF7 MEF2D
Knee pain experienced in last month 3.51 2 0 0.0 0.00 1.0e+00 RABGAP1L SDCCAG8
Hypertension (Self-reported) 2.79 3 0 0.0 0.00 1.0e+00 CGREF1 FHL5 SDCCAG8
Whole body fat-free mass 1.90 3 1 3.0 0.00 1.0e+00 CGREF1 KLF7 UHRF1BP1
Leg fat-free mass (right) 2.15 2 1 3.0 0.00 1.0e+00 KLF7 UHRF1BP1
Arm fat percentage (left) 3.42 2 2 6.1 0.00 1.0e+00 ANKS1A UHRF1BP1
Mood swings 3.90 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Long-standing illness, disability or infirmity 2.66 2 0 0.0 0.00 1.0e+00 KLF7 UHRF1BP1
Friendships satisfaction 1.83 1 0 0.0 0.00 1.0e+00 TARS2
Mouth/teeth dental problems: Mouth ulcers 2.68 2 0 0.0 0.00 1.0e+00 LRRC37A4P SDCCAG8
Medication for cholesterol 2.87 1 0 0.0 0.00 1.0e+00 CGREF1
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.40 1 0 0.0 0.00 1.0e+00 CGREF1
Mineral and other dietary supplements 2.73 1 0 0.0 0.00 1.0e+00 LRP1
Asthma (self-reported) 3.33 3 0 0.0 0.00 1.0e+00 LRP1 TARS2 U91328.21
Osteoarthritis (self-reported) 2.31 1 0 0.0 0.00 1.0e+00 TARS2
Medication: Aspirin 4.05 2 0 0.0 0.00 1.0e+00 KLF7 MEF2D
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.72 2 2 6.1 0.00 1.0e+00 LRRC37A4P U91328.21
Whole body water mass 1.90 3 1 3.0 0.00 1.0e+00 CGREF1 KLF7 UHRF1BP1
Leg predicted mass (right) 2.19 3 1 3.0 0.00 1.0e+00 CGREF1 KLF7 UHRF1BP1
Arm fat mass (left) 3.38 2 2 6.1 0.00 1.0e+00 ANKS1A UHRF1BP1
Number of self-reported non-cancer illnesses 4.43 4 0 0.0 -1.00 1.2e-03 ANKS1A CGREF1 KLF7 UHRF1BP1
Average weekly champagne plus white wine intake 3.33 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Miserableness 3.70 3 0 0.0 0.00 1.0e+00 LRRC37A4P RABGAP1L SDCCAG8
Guilty feelings 2.33 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Medication: Blood pressure 2.92 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Pain type(s) experienced in last month: Hip pain 2.73 1 0 0.0 0.00 1.0e+00 TARS2
Supplements: Fish oil (including cod liver oil) 2.97 2 0 0.0 0.00 1.0e+00 KLF7 LRP1
High cholesterol (Self-reported) 3.78 1 1 3.0 0.00 1.0e+00 CGREF1
Medication: Paracetamol 13.34 9 3 9.1 -0.99 5.8e-07 CGREF1 FHL5 KIAA0776 LRP1 LRRC37A4P RABGAP1L SDCCAG8 TARS2 U91328.21
Medication: Atorvastatin 2.37 1 0 0.0 0.00 1.0e+00 CGREF1
Basal metabolic rate 2.14 2 1 3.0 0.00 1.0e+00 CGREF1 UHRF1BP1
Leg fat percentage (left) 4.17 3 2 6.1 0.00 1.0e+00 ANKS1A LRP1 UHRF1BP1
Arm fat-free mass (left) 1.95 2 1 3.0 0.00 1.0e+00 CGREF1 UHRF1BP1
Irritability 1.82 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Risk taking 1.94 2 0 0.0 0.00 1.0e+00 SDCCAG8 U91328.21
Ever had prostate specific antigen (PSA) test 2.71 1 0 0.0 0.00 1.0e+00 U91328.21
Diastolic blood pressure, automated reading 3.74 2 2 6.1 0.00 1.0e+00 SDCCAG8 U91328.21
Unable to work because of sickness or disability 1.57 1 0 0.0 0.00 1.0e+00 UHRF1BP1
Commuting to job workplace: Cycle 2.75 1 0 0.0 0.00 1.0e+00 UHRF1BP1
Myopia 2.81 1 0 0.0 0.00 1.0e+00 LRP1
Vascular/heart problems diagnosed by doctor 2.98 3 0 0.0 0.00 1.0e+00 CGREF1 MEF2D SDCCAG8
Pain experienced in last month 8.00 4 2 6.1 0.99 7.7e-03 ANKS1A FHL5 KLF7 LRP1
Impedance of whole body 1.48 3 1 3.0 0.00 1.0e+00 CGREF1 TARS2 UHRF1BP1
Leg fat mass (left) 3.98 2 2 6.1 0.00 1.0e+00 ANKS1A UHRF1BP1
Arm predicted mass (left) 2.03 2 1 3.0 0.00 1.0e+00 CGREF1 UHRF1BP1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 7 0.2005 1.78
GTEx Adipose Visceral Omentum 5 0.2456 1.88
GTEx Adrenal Gland 2 0.1373 1.81
GTEx Artery Aorta 7 0.2351 1.80
GTEx Artery Coronary 5 0.4227 1.91
GTEx Artery Tibial 11 0.2925 1.85
GTEx Brain Caudate basal ganglia 4 0.4348 1.70
GTEx Brain Cerebellar Hemisphere 4 0.2686 1.75
GTEx Brain Cerebellum 6 0.3027 1.90
GTEx Brain Cortex 5 0.4831 1.86
GTEx Brain Frontal Cortex BA9 4 0.4329 1.76
GTEx Brain Hippocampus 3 0.5725 1.81
GTEx Brain Hypothalamus 4 0.6780 1.71
GTEx Brain Nucleus accumbens basal ganglia 4 0.4624 1.91
GTEx Brain Putamen basal ganglia 5 0.8013 1.88
GTEx Breast Mammary Tissue 7 0.3546 1.84
GTEx Breast Mammary Tissue (Male) 7 0.5868 1.75
GTEx Breast Mammary Tissue (Female) 7 0.4258 1.76
GTEx Cells EBV-transformed lymphocytes 6 0.4216 1.90
GTEx Cells Transformed fibroblasts 6 0.1429 1.75
GTEx Colon Sigmoid 7 0.4788 1.84
GTEx Colon Transverse 6 0.2907 1.85
GTEx Esophagus Gastroesophageal Junction 6 0.4152 1.82
GTEx Esophagus Mucosa 9 0.2711 1.77
GTEx Esophagus Muscularis 9 0.2785 1.81
GTEx Heart Atrial Appendage 5 0.3167 1.73
GTEx Heart Left Ventricle 5 0.3268 1.76
GTEx Liver 2 0.2789 1.86
GTEx Lung 10 0.3481 1.78
GTEx Muscle Skeletal 7 0.2422 1.77
GTEx Nerve Tibial 8 0.1851 1.74
GTEx Ovary 5 0.5507 1.84
GTEx Pancreas 5 0.3064 1.91
GTEx Pituitary 3 0.2691 1.84
GTEx Prostate 4 0.4790 1.86
GTEx Skin Not Sun Exposed Suprapubic 6 0.2440 1.92
GTEx Skin Sun Exposed Lower leg 10 0.2747 1.78
GTEx Small Intestine Terminal Ileum 3 0.6508 2.05
GTEx Spleen 2 0.1417 1.81
GTEx Stomach 6 0.4127 1.90
GTEx Testis 9 0.2853 1.79
GTEx Thyroid 7 0.1750 1.74
GTEx Uterus 6 1.0582 1.96
GTEx Vagina 4 0.6299 1.92
GTEx Whole Blood 5 0.2509 1.73
METSIM Adipose 4 0.0868 1.62
NTR Blood 4 0.1665 1.62
ROSMAP Brain Pre-frontal Cortex 2 0.0455 1.65
YFS Blood 0 0.0000 1.55
CommonMind Brain Pre-frontal Cortex 4 0.0744 1.66
TCGA Breast Tumor 0 0.0000 1.64
TCGA Breast Normal 0 0.0000 1.57
TCGA Ovarian Tumor 3 0.1027 1.49
TCGA Prostate Tumor 0 0.0000 1.62